pancreatitis

Summary

Summary: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

Top Publications

  1. pmc Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    Michael Elashoff
    Larry L Hillblom Islet Research Center at David Geffen School of Medicine and Department of Biomathematics, University of California, Los Angeles, California 90095 7073, USA
    Gastroenterology 141:150-6. 2011
  2. ncbi High serum IgG4 concentrations in patients with sclerosing pancreatitis
    H Hamano
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    N Engl J Med 344:732-8. 2001
  3. pmc Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model
    Belinda Gier
    Larry L Hillblom Islet Research Center, University of California Los Angeles UCLA, David Geffen School of Medicine, Los Angeles, California, USA
    Diabetes 61:1250-62. 2012
  4. pmc The epidemiology of pancreatitis and pancreatic cancer
    Dhiraj Yadav
    Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Gastroenterology 144:1252-61. 2013
  5. ncbi Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer
    Amaar Ghazale
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 102:1646-53. 2007
  6. ncbi Diagnosis of autoimmune pancreatitis: the Mayo Clinic experience
    Suresh T Chari
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:1010-6; quiz 934. 2006
  7. doi Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis
    Makoto Otsuki
    Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahata nishi ku, Kitakyushu 807 8555, Japan
    J Gastroenterol 43:403-8. 2008
  8. ncbi Endoscopic sphincterotomy complications and their management: an attempt at consensus
    P B Cotton
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Gastrointest Endosc 37:383-93. 1991
  9. doi International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology
    Tooru Shimosegawa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 40:352-8. 2011
  10. doi A diagnostic strategy to distinguish autoimmune pancreatitis from pancreatic cancer
    Suresh T Chari
    Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 7:1097-103. 2009

Research Grants

Detail Information

Publications361 found, 100 shown here

  1. pmc Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    Michael Elashoff
    Larry L Hillblom Islet Research Center at David Geffen School of Medicine and Department of Biomathematics, University of California, Los Angeles, California 90095 7073, USA
    Gastroenterology 141:150-6. 2011
    ..therapy is gaining widespread use for type 2 diabetes, although there are concerns about risks for pancreatitis and pancreatic and thyroid cancers...
  2. ncbi High serum IgG4 concentrations in patients with sclerosing pancreatitis
    H Hamano
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    N Engl J Med 344:732-8. 2001
    BACKGROUND: Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the pancreas, and hypergammaglobulinemia and that responds to ..
  3. pmc Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model
    Belinda Gier
    Larry L Hillblom Islet Research Center, University of California Los Angeles UCLA, David Geffen School of Medicine, Los Angeles, California, USA
    Diabetes 61:1250-62. 2012
    ..LSL-Kras(G12D) mice, exendin-4 led to acceleration of the disruption of exocrine architecture and chronic pancreatitis with mucinous metaplasia and increased formation of murine PanIN lesions...
  4. pmc The epidemiology of pancreatitis and pancreatic cancer
    Dhiraj Yadav
    Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Gastroenterology 144:1252-61. 2013
    Acute pancreatitis is one of the most frequent gastrointestinal causes of hospital admission in the United States. Chronic pancreatitis, although lower in incidence, significantly reduces patients' quality of life...
  5. ncbi Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer
    Amaar Ghazale
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 102:1646-53. 2007
    To determine the sensitivity and specificity of elevated serum IgG4 level for the diagnosis of autoimmune pancreatitis (AIP) and its ability to distinguish AIP from pancreatic cancer, its main differential diagnosis.
  6. ncbi Diagnosis of autoimmune pancreatitis: the Mayo Clinic experience
    Suresh T Chari
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:1010-6; quiz 934. 2006
    The Japan Pancreas Society criteria for diagnosis of autoimmune pancreatitis (AIP) mandate presence of characteristic imaging (diffuse pancreatic enlargement with diffusely irregular, narrow pancreatic duct)...
  7. doi Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis
    Makoto Otsuki
    Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahata nishi ku, Kitakyushu 807 8555, Japan
    J Gastroenterol 43:403-8. 2008
    ..2002, the Japan Pancreas Society (JPS) was the first in the world to propose diagnostic criteria for autoimmune pancreatitis (AIP)...
  8. ncbi Endoscopic sphincterotomy complications and their management: an attempt at consensus
    P B Cotton
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Gastrointest Endosc 37:383-93. 1991
    ..We emphasize particularly the importance of specialist training, disinfection, drainage, and collaboration with surgical colleagues...
  9. doi International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology
    Tooru Shimosegawa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 40:352-8. 2011
    To achieve the goal of developing international consensus diagnostic criteria (ICDC) for autoimmune pancreatitis (AIP).
  10. doi A diagnostic strategy to distinguish autoimmune pancreatitis from pancreatic cancer
    Suresh T Chari
    Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 7:1097-103. 2009
    Autoimmune pancreatitis (AIP) and pancreatic cancer (PaC) have similar presentations; a diagnostic strategy is needed to distinguish the 2 diseases.
  11. doi Japanese clinical guidelines for autoimmune pancreatitis
    Kazuichi Okazaki
    Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Osaka, Japan
    Pancreas 38:849-66. 2009
    As the patients with autoimmune pancreatitis (AIP) are increasing in Japan, the practical guideline for managing AIP is required to be established.
  12. doi Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence
    Carmen Guerra
    Experimental Oncology, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Cancer Cell 19:728-39. 2011
    ..intraepithelial neoplasias (mPanIN) and ductal adenocarcinomas (mPDAC) if exposed to limited bouts of non-acute pancreatitis, providing they harbor K-Ras oncogenes...
  13. ncbi A new clinicopathological entity of IgG4-related autoimmune disease
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, 113 8677, Tokyo, Japan
    J Gastroenterol 38:982-4. 2003
    Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases.
  14. pmc Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study
    Rebecca A Noel
    Eli Lilly and Company, Indianapolis, Indiana, USA
    Diabetes Care 32:834-8. 2009
    The objective of this study was to assess the risk of acute pancreatitis in patients with type 2 diabetes compared with that in patients without diabetes...
  15. doi Models of acute and chronic pancreatitis
    Markus M Lerch
    Department of Medicine A, University Medicine Greifswald, Ferdinand Sauerbruch Strasse, Greifswald, Germany
    Gastroenterology 144:1180-93. 2013
    Animal models of acute and chronic pancreatitis have been created to examine mechanisms of pathogenesis, test therapeutic interventions, and study the influence of inflammation on the development of pancreatic cancer...
  16. doi IgG4-related diseases including Mikulicz's disease and sclerosing pancreatitis: diagnostic insights
    Yasufumi Masaki
    Department of Hematology and Immunology, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
    J Rheumatol 37:1380-5. 2010
    Since the first report of serum IgG4 elevation in sclerosing pancreatitis in 2001, various systemic disorders have been reported to elevate IgG4, and many names have been proposed from the perspective of the systemic condition...
  17. pmc Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal
    Kazuichi Okazaki
    The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan
    J Gastroenterol 41:626-31. 2006
  18. doi Immunoglobulin G4-associated cholangitis: clinical profile and response to therapy
    Amaar Ghazale
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 134:706-15. 2008
    ..We describe clinical features, treatment response, and predictors of relapse in IAC and compare relapse rates in IAC with intrapancreatic vs proximal bile duct strictures...
  19. pmc Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo, 113 8677, Japan
    J Gastroenterol 41:613-25. 2006
    Autoimmune pancreatitis (AIP) is a peculiar type of pancreatitis of presumed autoimmune etiology. Many new clinical aspects of AIP have been clarified during the past 10 years, and AIP has become a distinct entity recognized worldwide...
  20. doi Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease
    Reiko Akitake
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Gut 59:542-5. 2010
    ....
  21. doi Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial
    Marc G H Besselink
    Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands
    Lancet 371:651-9. 2008
    Infectious complications and associated mortality are a major concern in acute pancreatitis. Enteral administration of probiotics could prevent infectious complications, but convincing evidence is scarce...
  22. ncbi Acute tubulointerstitial nephritis associated with autoimmune-related pancreatitis
    Yoko Uchiyama-Tanaka
    Department of Medicine II, Kansai Medical University, Osaka, Japan
    Am J Kidney Dis 43:e18-25. 2004
    ..We present a first case of acute TIN associated with autoimmune-related pancreatitis (AIP)...
  23. ncbi Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
    D C Whitcomb
    Dept of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Nat Genet 14:141-5. 1996
    Hereditary pancreatitis (HP) is a rare, early-onset genetic disorder characterized by epigastric pain and often more serious complications...
  24. ncbi The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice
    David J van Westerloo
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gastroenterology 130:1822-30. 2006
    ..This anti-inflammatory effect is mediated by an interaction of acetylcholine, the principal neurotransmitter of the vagus nerve, with macrophage cholinergic nicotinic receptors expressing the alpha7 subunit...
  25. doi Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study
    Sonal Singh
    Department of Medicine, The Johns Hopkins University School of Medicine and Public Health, Baltimore, MD 21287, USA
    JAMA Intern Med 173:534-9. 2013
    Acute pancreatitis has significant morbidity and mortality...
  26. doi Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas
    J S Nachnani
    Division of Gastroenterology and Hepatology, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Diabetologia 53:153-9. 2010
    ..Many reports describe an increased incidence of acute pancreatitis in humans treated with exendin-4 (exenatide)...
  27. pmc Exenatide does not evoke pancreatitis and attenuates chemically induced pancreatitis in normal and diabetic rodents
    Krystyna Tatarkiewicz
    Amylin Pharmaceuticals, San Diego, CA, USA
    Am J Physiol Endocrinol Metab 299:E1076-86. 2010
    The risk of developing pancreatitis is elevated in type 2 diabetes and obesity. Cases of pancreatitis have been reported in type 2 diabetes patients treated with GLP-1 (GLP-1R) receptor agonists...
  28. doi Standard steroid treatment for autoimmune pancreatitis
    T Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8677, Japan
    Gut 58:1504-7. 2009
    To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP).
  29. ncbi Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer
    Craig D Logsdon
    Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 63:2649-57. 2003
    ..genes expressed in pancreatic cancer have been hampered by similarities between adenocarcinoma and chronic pancreatitis. In the current study, microarrays (Affymetrix) were used to profile gene expression in pancreatic ..
  30. pmc Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    John P Morris
    Diabetes Center, Department of Medicine, UCSF, San Francisco, California 94143, USA
    J Clin Invest 120:508-20. 2010
    ..WT mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a process characterized by transient reactivation of pathways involved in embryonic pancreatic development...
  31. pmc A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis
    B Joseph Elmunzer
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    N Engl J Med 366:1414-22. 2012
    Preliminary research suggests that rectally administered nonsteroidal antiinflammatory drugs may reduce the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP).
  32. doi Serologic issues in IgG4-related systemic disease and autoimmune pancreatitis
    Raghuwansh P Sah
    Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Curr Opin Rheumatol 23:108-13. 2011
    IgG4-related systemic disease (ISD) is a recently recognized syndrome affecting multiple organs. Autoimmune pancreatitis (AIP) is the pancreatic manifestation of ISD and mimics pancreatic cancer...
  33. ncbi Clinical practice. Acute pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, PA 15213, USA
    N Engl J Med 354:2142-50. 2006
  34. doi Recent concepts of autoimmune pancreatitis and IgG4-related disease
    Kazuichi Okazaki
    The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Shinmachi, Hirakata, Osaka, Japan
    Clin Rev Allergy Immunol 41:126-38. 2011
    Recent studies suggested the existence of two subtypes of autoimmune pancreatitis (AIP): type 1 related with IgG4 (lymphoplasmacytic sclerosing pancreatitis; LPSP) and type 2 related with a granulocytic epithelial lesion (idiopathic duct-..
  35. ncbi Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration: clinicopathologic features of 35 cases
    Kenji Notohara
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 27:1119-27. 2003
    To clarify clinicopathologic features of idiopathic chronic pancreatitis with lymphoplasmacytic infiltration, we carried out a study of 35 cases...
  36. pmc Acute pancreatitis in association with type 2 diabetes and antidiabetic drugs: a population-based cohort study
    Antonio Gonzalez-Perez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Diabetes Care 33:2580-5. 2010
    Previous observational studies have found an increased risk of acute pancreatitis among type 2 diabetic patients. However, limited information is available on this association and specifically on the role of antidiabetic treatment...
  37. pmc Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis
    P Mews
    Pancreatic Research Group, University of New South Wales, Sydney, Australia
    Gut 50:535-41. 2002
    ..activation during pancreatic necroinflammation include cytokines known to be important in the pathogenesis of acute pancreatitis, such as tumour necrosis factor alpha (TNF-alpha), and the interleukins 1, 6, and 10 (IL-1, IL-6, and IL-10).
  38. ncbi The role of inflammatory and parenchymal cells in acute pancreatitis
    A Vonlaufen
    Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia
    J Pathol 213:239-48. 2007
    The infiltration of inflammatory cells into the pancreas is an early and central event in acute pancreatitis that promotes local injury and systemic complications of the disease...
  39. ncbi Helicobacter pylori and autoimmune pancreatitis: role of carbonic anhydrase via molecular mimicry?
    F Guarneri
    Istituto di Dermatologia, Policlinico Gaetano Martino, Universita di Messina, Messina, Italy
    J Cell Mol Med 9:741-4. 2005
    Autoimmune pancreatitis is a recently defined nosological entity, which accounts for 4.6-6% of all forms of chronic pancreatitis and is often associated with other autoimmune diseases, particularly Sjogren's syndrome...
  40. ncbi Acute pancreatitis: bench to the bedside
    Stephen J Pandol
    Department of Medicine, Department of Veterans Affairs and University of California, Los Angeles, California, USA
    Gastroenterology 132:1127-51. 2007
  41. ncbi Early NF-kappaB activation is associated with hormone-induced pancreatitis
    I Gukovsky
    Department of Medicine, Veterans Affairs Medical Center, West Los Angeles and University of California, Los Angeles, California 90073, USA
    Am J Physiol 275:G1402-14. 1998
    Inflammation and cell death are critical to pathogenesis of acute pancreatitis. Here we show that transcription factor nuclear factor-kappaB (NF-kappaB), which regulates these processes, is activated and plays a role in rat cerulein ..
  42. pmc Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice
    Jacqueline A Koehler
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Diabetes 58:2148-61. 2009
    Clinical reports link use of the glucagon-like peptide-1 receptor (GLP-1R) agonists exenatide and liraglutide to pancreatitis. However, whether these agents act on the exocrine pancreas is poorly understood.
  43. ncbi Ulinastatin for pancreatitis after endoscopic retrograde cholangiopancreatography: a randomized, controlled trial
    Takeshi Tsujino
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Gastroenterol Hepatol 3:376-83. 2005
    b>Pancreatitis remains the major complication of endoscopic retrograde cholangiopancreatography (ERCP), and hyperenzymemia after ERCP is common...
  44. ncbi Autoimmune pancreatitis: imaging features
    Dushyant V Sahani
    Department of Radiology, Massachusetts General Hospital, White Bldg 270F, 55 Fruit St, Boston MA 02114, USA
    Radiology 233:345-52. 2004
    To retrospectively determine imaging findings in patients with autoimmune pancreatitis.
  45. pmc Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis
    Rajesh Garg
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 33:2349-54. 2010
    Cases of acute pancreatitis have been reported in association with exenatide, sitagliptin, and type 2 diabetes without use of these medications. It remains unknown whether exenatide or sitagliptin increase the risk of acute pancreatitis.
  46. ncbi Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
    Jan Nygaard Jensen
    Barbara Davis Center for Childhood Diabetes, U Colorado, HSC, 4200 E 9th Avenue, B140, Denver, Colorado 80262 USA
    Gastroenterology 128:728-41. 2005
    ..To define cell differentiation changes associated with pancreatic regeneration in adult mice, we compared regeneration following caerulein-induced pancreatitis to that of normal pancreatic development.
  47. ncbi Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry
    Jianjun Shen
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas, USA
    Cancer Res 64:9018-26. 2004
    ..expressed proteins in six cases of pancreatic adenocarcinoma, two normal adjacent tissues, seven cases of pancreatitis, and six normal pancreatic tissues...
  48. ncbi Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis
    Hideaki Hamano
    Second Department of Internal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621, Matsumoto, Japan
    Lancet 359:1403-4. 2002
    Sclerosing pancreatitis is associated with raised concentrations of IgG4...
  49. doi Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions
    Seung Hyeok Seok
    Department of Microbiology and Immunology, and Institute of Endemic Disease, Seoul National University College of Medicine, Seoul, 110 799, Korea
    J Appl Toxicol 33:1089-96. 2013
    ..8 mg kg(-1) ZnO NPs had significant changes in anemia-related hematologic parameters. Mild to moderate pancreatitis also developed in both sexes dosed at 536...
  50. doi Piperine ameliorates the severity of cerulein-induced acute pancreatitis by inhibiting the activation of mitogen activated protein kinases
    Gi Sang Bae
    Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, 540 749 Jeonbuk, South Korea
    Biochem Biophys Res Commun 410:382-8. 2011
    ..In this study, we investigated whether piperine reduces the severity of cerulein-induced acute pancreatitis (AP)...
  51. pmc Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis
    Hidehiro Sawa
    Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Sciences, Kobe 650 0017, Japan
    World J Gastroenterol 12:7666-70. 2006
    To examine the effects of anti-high mobility group box 1 (HMGB1) neutralizing antibody in experimental severe acute pancreatitis (SAP).
  52. pmc Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)
    E J Duell
    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology ICO IDIBELL, Barcelona, Spain
    Ann Oncol 23:2964-70. 2012
    b>Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction.
  53. ncbi Pathophysiology of acute pancreatitis
    Madhav Bhatia
    Department of Pharmacology, National University of Singapore, Singapore
    Pancreatology 5:132-44. 2005
    Acute pancreatitis is a common clinical condition. It is a disease of variable severity in which some patients experience mild, self-limited attacks while others manifest a severe, highly morbid, and frequently lethal attack...
  54. ncbi Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens
    Giuseppe Zamboni
    Department of Pathology, University of Verona, Verona, Italy
    Virchows Arch 445:552-63. 2004
    Autoimmune pancreatitis seems to be a disease with a heterogeneous appearance...
  55. doi A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer
    Carlos Alves
    Health Technology Assessment HTA Centre, AIBILI, Coimbra, Portugal
    Diabetes Res Clin Pract 98:271-84. 2012
    The association between GLP-1 agonists, acute pancreatitis (AP), any cancer and thyroid cancer is discussed...
  56. ncbi Complications of diagnostic and therapeutic ERCP: a prospective multicenter study
    E Masci
    Gastroenterology and Endoscopic Unit, S. Raffaele Hospital, Milan, Italy
    Am J Gastroenterol 96:417-23. 2001
    ..ERCP/ES) can be associated with unforeseeable complications, especially when involving postprocedural pancreatitis. The aim of the study was to investigate risk factors for complications of ERCP/ES in a prospective ..
  57. doi The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis
    Niels Vrang
    Gubra ApS, Hørsholm, Denmark
    Am J Physiol Endocrinol Metab 303:E253-64. 2012
    A possible association between glucagon-like peptide-1 (GLP-1) analogs and incidences of pancreatitis has been suggested based on clinical studies...
  58. ncbi Meta-analysis: allopurinol in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitis
    Y Bai
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
    Aliment Pharmacol Ther 28:557-64. 2008
    ..evaluating the prophylactic effect of allopurinol on postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis have been published; however, there is no consensus on whether prophylactic allopurinol can reduce the ..
  59. doi Human bone marrow-derived clonal mesenchymal stem cells inhibit inflammation and reduce acute pancreatitis in rats
    Kyung Hee Jung
    Department of Biomedical Sciences, College of Medicine, Inha University, Sinheung Dong, Jung Gu, Incheon, Republic of Korea
    Gastroenterology 140:998-1008. 2011
    Acute pancreatitis (AP) has a high mortality rate; repetitive AP induces chronic AP and pancreatic adenocarcinoma. Mesenchymal stem cells (MSCs) have immunoregulatory effects and reduce inflammation...
  60. doi Clinical management of patients with acute pancreatitis
    Bechien U Wu
    Center for Pancreatic Care, Southern California Permanente Medical Group, Department of Gastroenterology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA
    Gastroenterology 144:1272-81. 2013
    Acute pancreatitis is the leading cause of hospitalization for gastrointestinal disorders in the United States. As rates of hospitalization for acute pancreatitis continue to increase, so does demand for effective management...
  61. ncbi Secular trends in incidence and 30-day case fatality of acute pancreatitis in North Jutland County, Denmark: a register-based study from 1981-2000
    A Floyd
    Dept of Clinical Epidemiology, Aalborg Hospital, Stengade 10, DK 9000 Aalborg, Denmark
    Scand J Gastroenterol 37:1461-5. 2002
    The incidence rate of acute pancreatitis has been reported as having increased during recent decades in Western countries. Reported mortality lies around 10% and has improved during the past 20 years...
  62. doi IgG4-related sclerosing disease: autoimmune pancreatitis and extrapancreatic manifestations
    Paraskevi A Vlachou
    Department of Medical Imaging and Pathology, University of Toronto, Toronto, Canada
    Radiographics 31:1379-402. 2011
    Autoimmune pancreatitis is the pancreatic manifestation of IgG4-related sclerosing disease, which recently was recognized as a distinct disease entity...
  63. ncbi Autoimmune pancreatitis: a systemic immune complex mediated disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 30:1537-45. 2006
    Autoimmune pancreatitis (AIP) is a mass forming inflammatory pancreatobiliary-centric disease...
  64. doi Autoimmune pancreatitis and IgG4-related sclerosing disease
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8677, Japan
    Nat Rev Gastroenterol Hepatol 7:401-9. 2010
    Autoimmune pancreatitis (AIP) is a unique form of pancreatitis in which the pathogenesis is suspected to involve autoimmune mechanisms...
  65. doi Pancreatitis in inflammatory bowel diseases
    C S Pitchumoni
    Gastroenterology, Hepatology, and Clinical Nutrition, Saint Peters University Hospital, New Brunswick, NJ, USA
    J Clin Gastroenterol 44:246-53. 2010
    ..Although infrequent, acute pancreatitis, and less often chronic pancreatitis, may occur as a result of the disease itself or secondary to the ..
  66. doi A prospective randomized trial of cannulation technique in ERCP: effects on technical success and post-ERCP pancreatitis
    A A Bailey
    Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, Sydney, Australia
    Endoscopy 40:296-301. 2008
    Inadvertent injection of contrast agent into the pancreatic duct is believed to be an important contributor to pancreatitis occurring after endoscopic retrograde cholangiopancreatography (post-ERCP pancreatitis, PEP)...
  67. ncbi Renal involvement in patients with autoimmune pancreatitis: CT and MR imaging findings
    Naoki Takahashi
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Radiology 242:791-801. 2007
    To retrospectively evaluate computed tomographic (CT) and magnetic resonance (MR) imaging renal findings at clinical presentation, during treatment, and at follow-up in patients with autoimmune pancreatitis (AIP).
  68. doi Distinctive pulmonary histopathology with increased IgG4-positive plasma cells in patients with autoimmune pancreatitis: report of 6 and 12 cases with similar histopathology
    Bijayee Shrestha
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Am J Surg Pathol 33:1450-62. 2009
    Autoimmune pancreatitis (AP) is one manifestation of a systemic, steroid-responsive disease with elevated serum IgG4 and characteristic histopathology, including increased IgG4-positive (+) plasma cells in the tissue...
  69. pmc Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis
    Hyacinth M Irving
    Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada
    JOP 10:387-92. 2009
    Epidemiologic studies have suggested an association between alcohol consumption and pancreatitis, although the exact dose-response relationship is unknown. It also remains uncertain whether a threshold effect exists.
  70. doi Risk of acute pancreatitis in type 2 diabetes and risk reduction on anti-diabetic drugs: a population-based cohort study in Taiwan
    Shih Wei Lai
    School of Medicine, China Medical University, Taichung City, Taiwan, ROC
    Am J Gastroenterol 106:1697-704. 2011
    The objective of this study was to assess the risk of acute pancreatitis among patients with type 2 diabetes mellitus (DM) and identify the roles of co-morbidities and anti-diabetic drugs.
  71. doi Prediction of mortality in acute pancreatitis: a systematic review of the published evidence
    G Gravante
    Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK
    Pancreatology 9:601-14. 2009
    In this review, we focus on studies that examined such prognostic indices in relation to predicting a fatal outcome from pancreatitis.
  72. ncbi Interaction between cytokines and oxidative stress in acute pancreatitis
    Javier Pereda
    Department of Physiology, School of Medicine, University of Valencia, Spain
    Curr Med Chem 13:2775-87. 2006
    Acute pancreatitis is an inflammation initially localized in the pancreatic gland which may lead to local and systemic complications...
  73. doi IgG4-related sclerosing cholangitis and autoimmune pancreatitis: histological assessment of biopsies from Vater's ampulla and the bile duct
    Hiroshi Kawakami
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Gastroenterol Hepatol 25:1648-55. 2010
    Autoimmune pancreatitis is commonly associated with immunoglobulin (Ig) G4-related sclerosing cholangitis (IgG4-SC)...
  74. doi Can wire-guided cannulation prevent post-ERCP pancreatitis? A prospective randomized trial
    Tae Hoon Lee
    Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea
    Gastrointest Endosc 69:444-9. 2009
    Among the procedure-related factors associated with post-ERCP pancreatitis, selective cannulation of the common bile duct by insertion of a guidewire may be associated with fewer complications than conventional methods of cannulation with ..
  75. pmc Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling
    Stacy A Blaine
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 0443, USA
    Development 137:2289-96. 2010
    ..cells are continuous with duct cells in the epithelium that makes up the hyperplastic ducts of both chronic pancreatitis and pancreatic cancer in humans...
  76. pmc Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras
    CATHERINE CARRIERE
    Department of Medicine, Dartmouth Medical School, Hanover, NH 03755, USA
    Biochem Biophys Res Commun 382:561-5. 2009
    Chronic pancreatitis increases by 16-fold the risk of developing pancreatic ductal adenocarcinoma (PDAC), one of the deadliest human cancers. It also appears to accelerate cancer progression in genetically engineered mouse models...
  77. ncbi Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response
    K Okazaki
    Department of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital, Kyoto, Japan
    Gastroenterology 118:573-81. 2000
    Although autoimmunity may be involved in some cases of pancreatitis, the mechanism is still unknown...
  78. ncbi A case of retroperitoneal and mediastinal fibrosis exhibiting elevated levels of IgG4 in the absence of sclerosing pancreatitis (autoimmune pancreatitis)
    Yoh Zen
    Division of Pathology, Kanazawa University Hospital, Japan
    Hum Pathol 37:239-43. 2006
    ..is now increasing evidence that IgG4 is closely involved in idiopathic sclerosing lesions, such as sclerosing pancreatitis and sclerosing sialadenitis...
  79. doi Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Pathol 39:1548-51. 2008
    ..Histologic evaluation of the specimen revealed synchronous autoimmune pancreatitis (lymphoplasmacytic sclerosing pancreatitis) and infiltrating ductal adenocarcinoma of the pancreas...
  80. pmc A better model of acute pancreatitis for evaluating therapy
    J Schmidt
    Departments of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114
    Ann Surg 215:44-56. 1992
    Existing models of acute pancreatitis have limitations to studying novel therapy. Whereas some produce mild self-limited pancreatitis, others result in sudden necrotizing injury...
  81. ncbi Practice guidelines in acute pancreatitis
    Peter A Banks
    Division of Gastroenterology, Center for Pancreatic Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Gastroenterol 101:2379-400. 2006
  82. ncbi Role of hydrogen sulfide in acute pancreatitis and associated lung injury
    Madhav Bhatia
    Department of Pharmacology, National University of Singapore, Faculty of Medicine, Bldg MD2, 18 Medical Dr, Singapore 117597, Singapore
    FASEB J 19:623-5. 2005
    ..arteries in vitro and to lower blood pressure in the rat, its effect in an inflammatory condition such as acute pancreatitis has not previously been reported...
  83. ncbi Prognostic factors in acute pancreatitis
    Stuart L Triester
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Gastroenterol 34:167-76. 2002
    The assessment of the severity of acute pancreatitis (AP) is a critical early step in its management, as severity of AP predicts prognosis...
  84. doi Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease
    Kazuichi Okazaki
    Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Shinmachi, Hirakata, Osaka 573 1197, Japan
    J Gastroenterol 46:277-88. 2011
    Recent studies have suggested the existence of two subtypes of autoimmune pancreatitis (AIP): type 1 AIP, related to IgG4 (lymphoplasmacytic sclerosing pancreatitis); and type 2 AIP, related to a granulocytic epithelial lesion (idiopathic ..
  85. ncbi Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor)
    Satoshi Kitagawa
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Am J Surg Pathol 29:783-91. 2005
    ..processes are suspected in its pathogenesis, and CSS is occasionally reported to be associated with sclerosing pancreatitis, an IgG4-related disease, the exact immunopathologic processes of CSS remain speculative...
  86. ncbi Cell death in pancreatitis: caspases protect from necrotizing pancreatitis
    Olga A Mareninova
    Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90073, USA
    J Biol Chem 281:3370-81. 2006
    Mechanisms of cell death in pancreatitis remain unknown. Parenchymal necrosis is a major complication of pancreatitis; also, the severity of experimental pancreatitis correlates directly with necrosis and inversely with apoptosis...
  87. ncbi Plasmapheresis for hyperlipidemic pancreatitis
    Jiann Horng Yeh
    Department of Neurology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Clin Apher 18:181-5. 2003
    Patients with triglyceride levels over 1,000 mg/dl are at high risk of developing acute pancreatitis. This study aimed to determine the effectiveness of plasma exchange (PE) in reducing triglyceride levels during an acute attack of ..
  88. ncbi Yield of EUS-guided FNA of pancreatic masses in the presence or the absence of chronic pancreatitis
    Shyam Varadarajulu
    Division of Gastroenterology Hepatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastrointest Endosc 62:728-36; quiz 751, 753. 2005
    Evaluation of a focal pancreatic mass in the setting of chronic pancreatitis (CP) is a diagnostic challenge...
  89. pmc Tropical chronic pancreatitis
    K K Barman
    M V Diabetes Specialities Centre, Madras Diabetes Research Foundation, Chennai, India
    Postgrad Med J 79:606-15. 2003
    Tropical chronic pancreatitis (TCP) is a juvenile form of chronic calcific non-alcoholic pancreatitis, seen almost exclusively in the developing countries of the tropical world...
  90. ncbi IgG4-positive plasma cells in inflammatory pseudotumor (plasma cell granuloma) of the lung
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 36:710-7. 2005
    The association between IgG4 dysregulation and inflammatory pseudotumor (IPT) was first reported in sclerosing pancreatitis. Recently, we described IPTs of the liver and breast, into both of which many IgG4-positive plasma cells had ..
  91. ncbi Autoimmune chronic pancreatitis
    Kyu pyo Kim
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
    Am J Gastroenterol 99:1605-16. 2004
    In recent years a peculiar type of chronic pancreatitis with underlying autoimmunity has been described...
  92. doi Acute pancreatitis
    Jean Louis Frossard
    Division de Gastroenterologie, Hopitaux Universitaires de Geneve, Geneva, Switzerland
    Lancet 371:143-52. 2008
    Acute pancreatitis is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom, and increased concentrations of serum amylase and lipase confirm the diagnosis...
  93. doi Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus
    Peter A Banks
    Division of Gastroenterology, Hepatology, and Endoscopy, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Gut 62:102-11. 2013
    The Atlanta classification of acute pancreatitis enabled standardised reporting of research and aided communication between clinicians. Deficiencies identified and improved understanding of the disease make a revision necessary.
  94. ncbi Cell death pathways in pancreatitis and pancreatic cancer
    Anna S Gukovskaya
    VA Greater Los Angeles Health Care System and University of California, Los Angeles, CA 90073, USA
    Pancreatology 4:567-86. 2004
    ..cell death pathways, is becoming exceedingly important in investigations of the pathogenesis and treatment of pancreatitis and pancreatic cancer...
  95. doi A cohort study of acute pancreatitis in relation to exenatide use
    D D Dore
    i3 Drug Safety, Waltham, MA, USA
    Diabetes Obes Metab 13:559-66. 2011
    Reports of acute pancreatitis associated with exenatide treatment prompted this study to estimate the association between acute pancreatitis and exenatide use relative to other antihyperglycaemic drugs.
  96. doi Japanese consensus guidelines for management of autoimmune pancreatitis: III. Treatment and prognosis of AIP
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo, Japan
    J Gastroenterol 45:471-7. 2010
    Steroid therapy appeared to be a standard treatment for autoimmune pancreatitis (AIP), although some AIP patients improve spontaneously...
  97. ncbi Prevention of post-ERCP pancreatitis: a comprehensive review
    Martin L Freeman
    Division of Gastroenterology, Hennepin County Medical Center, University of Minnesota, MN 55415, USA
    Gastrointest Endosc 59:845-64. 2004
  98. ncbi The Atlanta Classification of acute pancreatitis revisited
    T L Bollen
    Department of Radiology, St Antonius Hospital Nieuwegein, The Netherlands
    Br J Surg 95:6-21. 2008
    In a complex disease such as acute pancreatitis, correct terminology and clear definitions are important. The clinically based Atlanta Classification was formulated in 1992, but in recent years it has been increasingly criticized...
  99. doi Circulating naïve and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis
    Hideaki Miyoshi
    The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan
    Pancreas 36:133-40. 2008
    Autoimmune pancreatitis (AIP) is a new clinical entity of pancreatic disorder...
  100. ncbi Obesity is a definitive risk factor of severity and mortality in acute pancreatitis: an updated meta-analysis
    J Martinez
    Department of Gastroenterology, Hospital General Universitario de Alicante, Alicante, Spain
    Pancreatology 6:206-9. 2006
    Obesity is considered a risk factor in patients with acute pancreatitis. However, the relationship between obesity and mortality in this disease has not been confirmed definitively even in a previous meta-analysis...
  101. ncbi Propofol-associated hypertriglyceridemia and pancreatitis in the intensive care unit: an analysis of frequency and risk factors
    John W Devlin
    School of Pharmacy, Northeastern University, and the Department of Pharmacy, Tufts New England Medical Center, Boston, Massachusetts 02115, USA
    Pharmacotherapy 25:1348-52. 2005
    To characterize the frequency, severity, risk factors, and clinician response to propofol-associated hypertriglyceridemia and hypertriglyceridemia-associated pancreatitis.

Research Grants75

  1. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    Acute pancreatitis is an inflammatory condition with 5-10% mortality rate...
  2. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Chronic pancreatitis is a serious and painful disorder of exocrine pancreas with no effective therapeutic measures...
  3. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute pancreatitis is a common (incidence among the VA population is estimated at 1,100 per 100,000) and potentially lethal inflammatory process with a highly variable clinical course that progresses ..
  4. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    Gallstone pancreatitis is common and is potentially fatal...
  5. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..metabolites, bradykinin, and proteases such as trypsin, all of which may participate in the generation of acute pancreatitis. The current proposal examines the cellular and molecular mechanisms involved in sensory nerve activation ..
  6. HMG in Post Operative and Traumatic Stress
    Kevin J Tracey; Fiscal Year: 2013
    ..against inflammation, organ damage, and lethality in diverse animal models including severe sepsis, arthritis, pancreatitis, burn injury, acute lung injury, cerebral ischemia, hemorrhagic shock, colitis, and other inflammation and ..
  7. Resolving the role of nicotine-mediated phosphorylation on pancreatic fibrosis
    Joao A Paulo; Fiscal Year: 2013
    ..clearly the mechanisms of pancreatic disease to develop improved therapies to slow, halt, or ameliorate chronic pancreatitis and pancreatic cancer...
  8. Therapeutic Potential of PARP inhibitor for Acute Pancreatitis
    Latha Paka; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Acute Pancreatitis (AP) is a potentially lethal inflammatory disease of the pancreas...
  9. Online patient self-assessment for chronic pancreatic and other pain
    Andrew H Soll; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The pain associated with chronic pancreatitis is challenging to treat and to investigate. Chronic pancreatic pain (CPP) reflects multiple potential mechanisms: visceral factors (e.g...
  10. Dietary Regulation of Pancreatic Digestive Enzymes
    John A Williams; Fiscal Year: 2013
    ..The second form of growth that occurs following tissue injury such as pancreatitis involves dedifferentiation, cell division and dedifferentiation and will be referred to as regeneration...
  11. Obesity related pancreatic fat worsens local injury via unsaturated fatty acids
    VIJAY PREM SINGH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute Pancreatitis is potentially lethal when severe and is increasing in incidence, resulting in significant health care burden and costs. Obesity is associated with severe AP...
  12. Early Pathogenesis of Cystic Fibrosis Related Diabetes
    Andrew W Norris; Fiscal Year: 2013
    ..and Beta-cell ion channel physiology pertaining to insulin secretion (University of Chicago), diabetes and pancreatitis in CF animal models (University of Iowa), clinical studies in CFRD patients (University of Minnesota), and ..
  13. Development of PAR2 Inhibitors for the Treatment of Nonalcoholic steatohepatitis
    Athan Kuliopulos; Fiscal Year: 2013
    ..PZ-235 also significantly protected against severe pancreatitis, a common sequela seen with several of the newly approved type-II diabetes drugs...
  14. Ethanol Regulates Vacuolar ATPase &PEDF
    Chuhan Chung; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic pancreatitis (CP) is a major cause of morbidity and mortality. CP is also a major risk factor for the development of pancreatic cancer...
  15. Regulation of TRPV1 and Nociceptor Sensitization by the Complement System
    Yuriy M Usachev; Fiscal Year: 2013
    ..of C3a and C5a has been reported in various pathological states associated with pain, including arthritis, pancreatitis, inflammatory bowel disease, burns and surgical trauma...
  16. NAPS2 Continuation Genome Wide Association Study of Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2011
    b>Pancreatitis annually accounts for approximately 881,000 ambulatory care visits, 454,000 hospital discharges, and more than $2.5 billion in health care costs...
  17. Novel Strategies to Increase Insulin Independence after Islet Autotransplantation
    Hongjun Wang; Fiscal Year: 2013
    ..performed to treat intractable pain and to prevent "brittle" diabetes in well-selected patients with chronic pancreatitis. A major problem associated with TP-IAT is that the number of islets available for transplantation is ..
  18. Role of HDAC7 in T-cell Development
    ERIC M VERDIN; Fiscal Year: 2010
    ..Mice expressing this HDAC7 mutant protein in the thymus develop a striking autoimmune exocrine pancreatitis. Finally, both knockout and transgenic mice show distinct and abnormal distributions of CD4 effector T cells...
  19. Acetaldehyde and Epithelial Junctions: Role of PP2A and Occludin Phosphorylation
    MITZI LEE DUNAGAN; Fiscal Year: 2011
    ..Disruption of the barrier increases the risk of liver disease, pancreatitis, and cancer, so I am studying how acetaldehyde breaks connections between tight junction proteins and how to ..
  20. GABA-B-R-mediated prevention of pancreatic cancer
    Hildegard M Schuller; Fiscal Year: 2013
    ..New strategies for PDAC prevention are therefore urgently needed. Using two risk factors for PDAC (pancreatitis and smoking), we have established a hamster model of PDAC by inducing pancreatitis in the animals via ethanol ..
  21. Novel Breath Test To Detect Early Stage Chronic Pancreatitis
    DAVID A contact WAGNER; Fiscal Year: 2010
    ..The incidence rate of chronic pancreatitis (CP) is rapidly increasing and may be related to expanded alcohol abuse...
  22. Islet and Mesenchymal Stem Cell Co-transplantation Prevents Onset of Diabetes
    Hongjun Wang; Fiscal Year: 2013
    ..TP-IAT) are currently being performed to treat intractable pain in selected patients with chronic pancreatitis (CP)...
  23. TripleTOF 5600 Hybrid Mass Spectrometer
    Hanno Steen; Fiscal Year: 2012
    ..for example: identifying biomarkers for chronic pelvic pain, Ureteropelvic junction (UPJ) obstruction and pancreatitis, understanding the pathophysiology of Sudden Infant Death Syndrome (SIDS) and Spinal Muscular Atrophy (SMA), ..
  24. Partial-wave spectroscopic microscopy for the diagnosis of cholangiocarcinoma
    Yang Liu; Fiscal Year: 2010
    ..imaging techniques suffer from either low sensitivity and sometimes lead to significant complications such as pancreatitis and cholangitis...
  25. Trafficking mechanisms for secretory vesicles in pancreatic duct epithelial cells
    Duk Su Koh; Fiscal Year: 2013
    ..by applicant): It is generally believed that the pancreas is challenged by two harmful insults during acute pancreatitis, pathologically activated trypsin, released from acinar cells, and bile acids flowing into pancreatic ducts ..
  26. The GABA-B receptor is a novel drug target for pancreatic cancer
    Hildegard M Schuller; Fiscal Year: 2012
    ..PDAC) is the fourth leading cause of cancer mortality in Western countries and smoking, diabetes, and pancreatitis are risk factors...
  27. Microbiomes in Human Pancreatic Cancer
    Dominique S Michaud; Fiscal Year: 2013
    ..Chronic pancreatitis and inflammation are thought to play a critical role in pancreatic carcinogenesis...
  28. Effects of Artemin on Nociceptors
    KATHRYN MARIE ALBERS; Fiscal Year: 2013
    ..as growth factors, acetylcholine, glutamate and peptides is commonly elevated in inflammatory diseases such as pancreatitis, psoriasis, rheumatoid arthritis and cystitis...
  29. Pancreas Transcription Factors and Disease Model Systems
    Stephen F Konieczny; Fiscal Year: 2013
    ..lead to several critical human diseases, including diabetes and two diseases of the exocrine pancreas - pancreatitis and pancreatic cancer...
  30. Alcohol abuse and Endoplasmic Reticulum dysfunction in exocrine pancreas
    Aurelia Lugea; Fiscal Year: 2013
    ..effects of alcohol that cause ER dysfunction and promote its propagation into pathophysiologic features of pancreatitis including aberrant digestive enzyme activation and acinar cell death...
  31. Safety and Effectiveness Evaluations for Diabetes
    DONALD READ MILLER; Fiscal Year: 2013
    ..associated with thiazolidinedione use, risks of pneumonia associated with sitagliptin use, and risks of pancreatitis and acute kidney injury associated with exenatide use...
  32. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP RICHARD VULLIET; Fiscal Year: 2010
    ..LPL-deficiency is a serious autosomal recessive disorder characterized by severe chylomicronemia, pancreatitis, eruptive xanthomata, lipemia retinalis, memory loss and failure to thrive...
  33. Phytochemicals &Metabolism in Pancreatic Diseases/Pandol, Stephen
    Vay Liang W Go; Fiscal Year: 2011
    ..e. chronic pancreatitis) by identifying target pathways and beneficial effects of these molecules in foods and nutritional supplements...
  34. Dendritic Cell Activation by Mitochondrial Transcription Factor A
    Elliott D Crouser; Fiscal Year: 2010
    ..can become activated by "self-antigens" which are released during severe acute illnesses, such as trauma, pancreatitis or burns...
  35. Toll-like Receptor Regulation of Pancreatic Tumorigenesis
    George Miller; Fiscal Year: 2013
    ..in human pancreatic cancer and TLR expression as well as determine whether the progression of human chronic pancreatitis to pancreatic cancer is correlated with TLR expression levels...
  36. Effect of high fat diet on pancreatic cancer in IKKa deficient mice
    Ning Li; Fiscal Year: 2013
    ..loss of IKK? expression in pancreatic epithelial cells results in development of spontaneous fibrosis and pancreatitis in lean mice, pathologies that are associated with early cellular defects of diminished autophagic maturation ..
  37. Mechanisms of Pancreatic Thiamin Uptake:Effect of Alcohol
    Hamid M Said; Fiscal Year: 2013
    ..is known to exert profound effects on pancreatic physiology and gene expression, and is a leading cause of pancreatitis. Nothing, however, is known about the effect(s) of chronic alcohol consumption on thiamin uptake and metabolism ..
  38. Induced Reactive Oxygen Species in a 3-D Human Pancreatitis Model in Vitro
    Gregory P Botta; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The most common cause of Pancreatitis is excessive alcohol intake which has the potential to induce reactive oxygen species (ROS) leading to DNA damage and apoptosis...
  39. A novel diagnostic biomarker for hepatocellular carcinoma and cholangiocarcinoma
    Xuanyong Lu; Fiscal Year: 2012
    ..be used as a more effective biomarker for detecting HCC/ICC, this had been complicated by other disease such as pancreatitis also led to higher serum SPIK levels...
  40. Apoptosis and Necrosis in Pancreatitis
    Anna S Gukovskaya; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The pathologic processes that initiate and perpetuate acute pancreatitis remain unclear. A recognized feature of this disease is the accumulation of vacuoles in acinar cells...
  41. Mitochondrial Dysfunction, Permeability Transition Pore, and Acute Pancreatitis
    Anna S Gukovskaya; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): MITOCHONDRIAL DYSFUNCTION, PERMEABILITY TRANSITION PORE, AND ACUTE PANCREATITIS Key words: acute pancreatitis, pancreatic acinar cell, mitochondria, permeability transition pore, lysosomes, cathepsin, ..
  42. Genetic influences in experimental pancreatitis
    Bishr Omary; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pancreatitis, an acute or chronic inflammatory disease of the pancreas, results in significant morbidity and mortality in the United States and within our US veteran population...
  43. Defining the mechanisms of secretion in the Drosophila salivary gland
    REBECCA MARIE FOX; Fiscal Year: 2010
    ..loss of secretory control has been attributed to the pathogenesis of many human diseases, including pancreatitis and diabetes, as well as the blood cancer, multiple myeloma...
  44. ADAM17 in pancreatic cancer and pancreatitis
    Howard C Crawford; Fiscal Year: 2013
    ..Chronic pancreatitis (CP) is a risk factor for pancreatic ductal adenocarcinoma (PDA), presumably due to the pro-tumorigenic effects ..
  45. Early Detection of Pancreatic Cancer Using Ice COLD-PCR
    Grant Wu; Fiscal Year: 2012
    ..Further, this model system will allow the study of pancreatitis- related progression to pancreatic cancer stage 1 in a mutant K-RAS background...
  46. Aldo-keto reductase family 1 member B10 AKR1B10 in pancreatic carcinogenesis
    Guang Yu Yang; Fiscal Year: 2013
    ..Aim 1: To determine the chemopreventive effects and mechanism of diclofenac on mutant Kras-driven and pancreatitis-enhanced carcinogenesis in Pdx1Cre-KrasG12D mice (called PanKras)...
  47. Molecular Markers for the Diagnosis of Pancreatic Cancer
    Surinder K Batra; Fiscal Year: 2012
    ..and differential expression of MUC4 in pancreatic adenocarcinomas as compared to the normal pancreas or chronic pancreatitis tissues...
  48. Role of Intra-Pancreatic Trypsinogen Activation in Alcoholic Pancreatitis
    Rajinder K Dawra; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Role of intra-pancreatic trypsinogen activation in alcoholic pancreatitis ABSTRACT Pancreatitis is an inflammatory disease of the pancreas associated with significant morbidity and mortality and is ..
  49. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    RODERICK PAUL ROBERTSON; Fiscal Year: 2013
    ..Our approach is to study intrahepatic islet function in patients with chronic pancreatitis who undergo total pancreatectomy and autoislet transplantation (TP/AIT) in both hepatic and nonhepatic sites...
  50. Mediators of pancreatic cancer induction by alcoholic pancreatitis and smoking
    Mouad Edderkaoui; Fiscal Year: 2013
    ..Alcoholic chronic pancreatitis and smoking are major established risk factors for pancreatic cancer...
  51. RECEPTOR-REGULATED CALCIUM ENTRY IN EXOCRINE SECRETION
    Trevor J Shuttleworth; Fiscal Year: 2013
    ..or errors in these signals underlie a variety of different disease states including cancer, immunodeficiency, pancreatitis, and various muscular and neuronal diseases...
  52. Islet Biology in Cystic Fibrosis Related Diabetes
    Alvin C Powers; Fiscal Year: 2013
    ..Furthermore, the commonly accepted pathogenesis for the insulin deficiency, namely that the pancreatitis of cystic fibrosis (CF) and subsequent pancreatic atrophy and fibrosis lead to islet destruction, is not likely ..
  53. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok K Saluja; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pancreatitis is an inflammatory disease of the pancreas. Every year, over 225,000 patients are diagnosed with pancreatitis and over two billion dollars are spent on their care...
  54. Development of a Novel High-Throughput Screening Platform for BK Channel Modulato
    Frank T Horrigan; Fiscal Year: 2013
    ..heart disease, erectile dysfunction, urinary incontinence, gastric hypermotility, irritable bowel syndrome, pancreatitis, cancer (brain, bone, and prostate), rheumatoid arthritis, glaucoma and diabetes...
  55. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Investigations into the role of cyclooxygenase-2 (COX-2) in pancreatitis and pancreatic cancer have been very limited...
  56. Risk Factors for the Development of Lactic Acidosis and Pancreatitis Among HAART-
    William Wester; Fiscal Year: 2011
    ..has been associated with several long-term mitochondrial toxicities;these include lactic acidosis, pancreatitis, peripheral neuropathy, and peripheral fat wasting/atrophy...
  57. Acute pancreatitis and obesity
    Giamila Fantuzzi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute pancreatitis (AP) can range from a mild self-limited condition to a very severe life-threatening disease. Obesity is a risk factor for development of severe AP...
  58. Omega-3 Fatty Acid Effects on Pancreatitis and Adenocarcinoma Development
    Christopher A Jolly; Fiscal Year: 2013
    ..omega-3 fatty acid eicosapentaenoic acid (EPA) or the omega-6 fatty acid linoleic acid prior to the onset of pancreatitis. The COX-2 Tg mouse overexpresses the COX-2 gene which causes spontaneous pancreatitis and subsequent ..
  59. Obesity and Pancreatic Cancer: The Role of IGF-1
    Susan M Fischer; Fiscal Year: 2012
    ..by applicant: Obesity has increased dramatically over the past 30 years in the USA and has been associated with pancreatitis and pancreatic cancer, as well as other cancers...
  60. CTGF in Pancreatic Stellate Cell-Mediated Fibrogenesis
    David R Brigstock; Fiscal Year: 2011
    ..connective tissue growth factor (CTGF) in promoting pancreatic fibrosis, which is a common feature of chronic pancreatitis. CTGF stimulates vital biological processes such as chondrogenesis, angiogenesis and matrigenesis via its ..
  61. Investigation and treatment of central nervous system dysfunction in chronic pelv
    Felipe Fregni; Fiscal Year: 2010
    ..we showed that another technique of noninvasive brain stimulation reduces pain in chronic visceral pain due to pancreatitis and that changes in pain-related neural networks (as indexed by magnetic resonance spectroscopy) are found in ..
  62. IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer
    Michael Karin; Fiscal Year: 2013
    ..Major PanCa risk factors are old age, tobacco smoking, obesity, diabetes and chronic pancreatitis. It is also not clear if and how these risk factors accelerate progression of precursor lesions, which may be ..
  63. EFFECT OF ALCOHOL ON PANCREATIC SECRETION
    Jorge Valenzuela; Fiscal Year: 1990
    The pathogenesis of alcoholic pancreatitis remains obscure...
  64. A Novel Method to Isolate Islet Cells
    JERRY KNOBELOCH; Fiscal Year: 2007
    ..In addition, auto-islet transplantation for persons undergoing pancreatectomy for chronic pancreatitis has been performed with increasing success...
  65. NUTRITION SUPPORT EFFECT ON SEVERE ACUTE PANCREATITIS
    Stephen Martin; Fiscal Year: 1999
    DESCRIPTION (Taken from application) Severe acute pancreatitis is a systemic, hypermetabolic disease that occurs in 10% to 20% of all patients with acute pancreatitis and has a 30% to 50% mortality...
  66. ALTERED ACINAR CELL FUNCTION DURING ACUTE PANCREATITIS
    Robert Powers; Fiscal Year: 1992
    ..the concentration required to induce maximal secretion (hyperstimulation) leads to the rapid formation of acute pancreatitis in mice as defined by pancreatic edema and in-creased serum levels of anylase and lipase...
  67. Pioglitazone Therapy for Endocrine and Exocrine Disease in Alcoholic Pancreatitis
    MATTHEW DIMAGNO; Fiscal Year: 2009
    ..between diabetes mellitus or insulin resistance and reduced pancreatic exocrine secretion and/or chronic pancreatitis (CP)...
  68. Hypoxia and free radicals in alcoholic pancreatitis
    Gavin Arteel; Fiscal Year: 2005
    APPLICANT'S ABSTRACT: We hypothesize that ethanol-induced chronic pancreatitis is triggered by hypoxia/reoxygenation injury, leading to stimulation of inflammatory cell recruitment and activation of these cells by circulating endotoxins...
  69. Alcohol Screening Scores and Medical Outcomes: Age and Gender Influences
    ALEX SOX HARRIS; Fiscal Year: 2009
    ..g., liver disease, upper GI bleeding, and pancreatitis) 7, and acute alcohol use (e.g., traumatic injury)8, 9, as well as to mortality10...
  70. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2004
    ..Pancreatic acinar cells are critical for digestion of food and are involved in pathological states including pancreatitis and pancreatic cancer...
  71. TRANSCRIPTIONAL CONTROL OF INFLAMMATION IN PANCREATITIS
    Brent Neuschwander Tetri; Fiscal Year: 1999
    Acute pancreatitis is a disease that causes debilitating illness and death, yet its pathogenetic basis at the cellular level remains poorly understood...
  72. Fatty Acid Ethyl Esters in Ethanol-induced Pancreatitis
    Bhupendra Kaphalia; Fiscal Year: 2006
    b>Pancreatitis is a major health problem in alcoholics that causes high mortality and morbidity, and after biliary duct diseases, chronic alcohol abuse is the second major cause of chronic pancreatitis...
  73. NOVEL PROTEASE FORMULATION BASED ON CROSSLINKED CRYSTALS
    Bhami Shenoy; Fiscal Year: 2004
    ..from Aspergillus melleus, TheraCLEC-Protease, for use in the treatment of chronic abdominal pain in chronic pancreatitis and also along with TheraCLEC-Lipase and amylase for the treatment of malabsorption as a result of pancreatic ..
  74. Feasibility of Hemin-Based Therapy in Experimental Acute Pancreatitis
    M Omary; Fiscal Year: 2006
    ..we find that peritoneal cells isolated from hemin-treated mice home to the pancreas and protect from pancreatitis. Our central hypothesis is that direct or indirect hemin exposure protects mice from experimental acute ..
  75. SURGERY OF THE PANCREAS--EFFECTS ON GLUCOSE METABOLISM
    Dana Andersen; Fiscal Year: 1999
    ..Recent animal and clinical studies of chronic pancreatitis-induced diabetes suggest that hepatic insulin receptor function and hepatic glucose transporter content are ..