Genomes and Genes
Summary: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTIC DEHYDROGENASE; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Publications382 found, 100 shown here
- Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in miceIker Uriarte
Division of Hepatology and Gene Therapy, CIMA, University of Navarra, Clinic University of Navarra and CIBERehd, Pamplona, Spain
Gut 62:899-910. 2013..We evaluated the relevance of Fgf15 in the preservation of BA homeostasis after PH and its potential role in the regenerative process...
- Caspase 8 small interfering RNA prevents acute liver failure in miceLars Zender
Department of Gastroenterology, Medical School Hannover, 30625 Hannover, Germany
Proc Natl Acad Sci U S A 100:7797-802. 2003A major concern in therapy of acute liver failure is protection of hepatocytes to prevent apoptosis and maintain liver function. Small interfering RNA (siRNA) is a powerful tool to silence gene expression in mammalian cells...
- Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failureYong Zou
Department of Infectious Disease, Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Immunol 184:466-75. 2010..NK cells in the development of hepatocyte necrosis in fulminant hepatic failure (FHF) and acute-on-chronic liver failure (ACLF) because of viral infection...
- Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1Joydeep Das
Division of Molecular Medicine, Bose Institute, P 1 12, CIT Scheme VII M, Kolkata 700054, India
Free Radic Res 44:340-55. 2010..Taurine possesses prophylactic as well as therapeutic potentials against APAP-induced hepatic injury...
- Strategies for safer liver surgery and partial liver transplantationPierre Alain Clavien
Swiss Hepato Pancreatico Biliary HPB Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
N Engl J Med 356:1545-59. 2007
- Prediction of the prognosis of patients with acute-on-chronic hepatitis B liver failure using the model for end-stage liver disease scoring system and a novel logistic regression modelQ F Sun
Department of Infectious Diseases, The Third Affiliated Hospital of Wenzhou Medical College, Rui an, Zhejiang, China
J Viral Hepat 16:464-70. 2009..of the model for end-stage liver disease (MELD) scoring system in patients with acute-on-chronic hepatitis B liver failure (ACLF-HBV), and to establish a new model for predicting the prognosis of ACLF-HBV...
- Alginate-encapsulated HepG2 cells in a fluidized bed bioreactor maintain function in human liver failure plasmaSam M Coward
Centre for Hepatology, Royal Free Hospital and UCL Medical School, London, UK
Artif Organs 33:1117-26. 2009..This study investigates their performance in normal and liver failure (LF) human plasma over 6-8 h in a fluidized bed bioreactor...
- Nucleoside analogue can improve the long-term prognosis of patients with hepatitis B virus infection-associated acute on chronic liver failureYao Li Cui
Center of Infectious Diseases, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China
Dig Dis Sci 55:2373-80. 2010The prognosis of patients with hepatitis B virus (HBV)-associated acute on chronic liver failure (ACLF) is extremely poor.
- Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndromeIvan R Diamond
The Hospital for Sick Children, Toronto, Canada
J Pediatr Gastroenterol Nutr 48:209-15. 2009..Parenteral omega-3 fatty acids, such as Omegaven, may benefit patients with pediatric short bowel syndrome (SBS) who develop parenteral nutrition-associated liver disease (PNALD)...
- Impact of pretransplant MELD score on posttransplant outcome in orthotopic liver transplantation for patients with acute-on-chronic hepatitis B liver failureZ X Wang
Liver Transplantation Division, Department of Surgery, West China Hospital, Sichuan University Medical School, Chengdu 610041, Sichuan, China
Transplant Proc 39:1501-4. 2007..score in comparison with the Child-Turcotte-Pugh (CTP) score to predict short-term postoperative survival and 3-month morbidity among patients with acute-on-chronic hepatitis B liver failure undergoing orthotopic liver transplantation.
- Adjuvant therapeutic plasma exchange in liver failure: assessments of clinical and laboratory parametersMehmet Bektas
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
J Clin Gastroenterol 42:517-21. 2008..The aim of this study was to analyze the positive effects of TPE on clinical and biochemical parameters of liver failure.
- Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazoneR Rajagopalan
Takeda Pharmaceuticals North America, Inc, Lincolnshire, IL 60069, USA
Diabetes Obes Metab 7:161-9. 2005The aim of this study was to assess the incidence of liver failure in association with antidiabetic treatment using pioglitazone vs. other oral antidiabetic medications.
- Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS)Nuh N Rahbari
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
Surgery 149:713-24. 2011Posthepatectomy liver failure is a feared complication after hepatic resection and a major cause of perioperative mortality...
- Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1Brian S Zuckerbraun
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Exp Med 198:1707-16. 2003....
- Rituximab-related viral infections in lymphoma patientsSercan Aksoy
Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey
Leuk Lymphoma 48:1307-12. 2007..Close monitoring for viral infection, particularly HBV and CMV, in patients treated with rituximab should be recommended...
- Cirrhosis and chronic liver failure: part I. Diagnosis and evaluationJoel J Heidelbaugh
Department of Family Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Am Fam Physician 74:756-62. 2006Cirrhosis and chronic liver failure are leading causes of morbidity and mortality in the United States, with the majority of preventable cases attributed to excessive alcohol consumption, viral hepatitis, or nonalcoholic fatty liver ..
- Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failureWilliam M Lee
Division of Digestive and Liver Diseases, University of Texas, Southwestern Medical Center, Dallas, 75390 9151, USA
Hepatology 40:6-9. 2004..for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year. Data from the U.S...
- Interferon combined with cyclosporine treatment as an effective countermeasure against hepatitis C virus recurrence in liver transplant patients with end-stage hepatitis C virus related diseaseK Inoue
Showa University Fujigaoka Hospital, Yokohama, Japan
Transplant Proc 37:1233-4. 2005..We reported here the beneficial effect of combined interferon and cyclosporine treatment for chronic hepatitis C. We recommend this protocol for established HCV-related graft disease...
- Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failureAlex Hattoum
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Hum Pathol 44:743-9. 2013..Recent studies have shown that the same pathways may operate in human liver failure. The growth factor receptors (HGF [hepatocyte growth factor] receptor) and epidermal growth factor receptor ..
- The systemic inflammatory response syndrome in cirrhotic patients: relationship with their in-hospital outcomeMassimo Cazzaniga
Department of Internal Medicine, IRCCS Policlinico San Donato, University of Milan, 20097 San Donato Milanese, Milan, Italy
J Hepatol 51:475-82. 2009..We studied 141 cirrhotic patients consecutively admitted to a tertiary referral centre assessing prevalence of SIRS and its relationship with in-hospital outcome...
- Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failureHong Ye
Department of Hepatology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
World J Gastroenterol 19:2818-25. 2013To assess CD163 expression in plasma and peripheral blood and analyze its association with disease in acute-on-chronic hepatitis B liver failure (ACHBLF) patients.
- A bioartificial liver--state of the artAlastair J Strain
Schools of Biosciences and Medicine, University of Birmingham, and Liver and Hepatobiliary Unit, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
Science 295:1005-9. 2002..In these devices, patient plasma is circulated extracorporeally through a bioreactor that houses liver cells (hepatocytes) sandwiched between artificial plates or capillaries...
- Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine modelIchiro Ogushi
First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
Hepatology 38:335-44. 2003..In conclusion, NF-kappa B/decoy/ODN transfer in vivo effectively suppressed endotoxin-induced fatal liver injury in mice...
- Intestinal endotoxemia as a pathogenetic mechanism in liver failureDe Wu Han
Institute of Hepatology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
World J Gastroenterol 8:961-5. 2002..inflammatory responses, with serious hepatic necrosis, further severe hepatitis and even induces acute liver failure. The milder IETM successively precipitates a cascade, including repeated and persistent hepatocytic impairment ..
- Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in D-GalN/LPS induced acute liver failure in murine modelsYan Ling Wu
College of Pharmacy, Yanbian University, Yanji, 133002, Jilin Province, China
Chem Biol Interact 188:526-34. 2010The hepatoprotective effects and molecular mechanisms of baicalein on acute liver failure induced by d-galactosamine (d-GalN)/lipopolysaccharides (LPS) were investigated in vivo...
- Liver failure and defective hepatocyte regeneration in interleukin-6-deficient miceD E Cressman
Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
Science 274:1379-83. 1996....
- Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomesLiang Peng
Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
Hepatology 54:820-8. 2011Our study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after a single transplantation with autologous marrow mesenchymal stem cells (MMSCs)...
- Artificial and bioartificial liver devices: present and futureB Carpentier
UTC, UMR CNRS 6600 Biomechanics and Bioengineering, BP 20529, 60205 Compiegne Cedex, France
Gut 58:1690-702. 2009b>Liver failure is associated with high morbidity and mortality without transplantation. There are two types of device for temporary support: artificial and bioartificial livers...
- Post-liver transplant cholestatic hepatitis C: a systematic review of clinical and pathological findings and application of consensus criteriaTarun K Narang
Department of Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
Liver Transpl 16:1228-35. 2010..We propose that studies on PLTCHC use the consensus criteria for diagnosis and suggest clinical information that should be provided in future studies with the goal of improving our understanding and management of this deadly disease...
- Troglitazone-induced liver failure: a case studyDavid J Graham
Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, HFD 400, Room 15B 32, Rockville, MD 20857, USA
Am J Med 114:299-306. 2003Troglitazone was removed from the U.S. market because its use was associated with an increased risk of liver failure. We evaluated the clinical features of all cases reported to the Food and Drug Administration and estimated the duration ..
- Factors influencing renal function after liver transplantation. Results from the MOST, an international observational studyP Burra
Gastroenterology, Department of Surgical and Gastroenterological Sciences, University Hospital Padova, Padova, Italy
Dig Liver Dis 41:350-6. 2009..Given organ shortage it should be essential to determine which patients will experience progressive and severe renal dysfunction after liver transplantation (LT)...
- Prediction value of model for end-stage liver disease scoring system on prognosis in patients with acute-on-chronic hepatitis B liver failure after plasma exchange and lamivudine treatmentJian Wu Yu
Department of Infectious Diseases, Second Affiliated Hospital, Harbin Medical University, Harbin, China
J Gastroenterol Hepatol 23:1242-9. 2008..liver disease (MELD) scoring system to predict the 3-month prognosis of patients with acute-on-chronic liver failure (ACLF) after plasma exchange (PE) and lamivudine treatment, and studied the predictive factors on the ..
- Pig liver xenotransplantation as a bridge to allotransplantation: which patients might benefit?Burcin Ekser
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Transplantation 88:1041-9. 2009Acute liver failure is a potentially devastating clinical syndrome that, without liver transplantation (Tx), is associated with high mortality...
- Sorafenib-induced liver failureChristoph Schramm
Am J Gastroenterol 103:2162-3. 2008
- Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevanceB Ekser
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Transplant 10:273-85. 2010..human donor livers leads to a significant mortality in patients with acute-on-chronic or acute (fulminant) liver failure or with primary nonfunction of an allograft...
- Technology insight: artificial extracorporeal liver support--how does Prometheus compare with MARS?Peter Krisper
Universitaetsklinik für Innere Medizin, Abteilung für Nephrologie und Hämodialyse, Graz, Austria
Nat Clin Pract Nephrol 3:267-76. 2007Artificial extracorporeal liver support or 'liver dialysis' has been used in patients with severe liver failure with increasing frequency since the Molecular Adsorbents Recirculating System (MARS), a variant of albumin dialysis, was ..
- Predicting liver failure following major hepatectomyG Garcea
Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA 5011, Australia
Dig Liver Dis 41:798-806. 2009..Published data would not suggest any difference in mortality, morbidity or liver failure rates between these groups...
- Effective bilirubin reduction by single-pass albumin dialysis in liver failureUssanee Boonsrirat
Department of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand
Artif Organs 33:648-53. 2009Albumin dialysis is widely accepted as a liver-support technique for patients with liver failure. The Molecular Adsorbent Recirculating System, the widely accepted albumin dialysis technique, has limited use in developing countries ..
- Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletionMaite Herraiz
Division of Hepatology and Gene Therapy, University of Navarra, Medical School Pamplona, 31008 Pamplona, Spain
Hum Gene Ther 14:463-72. 2003..These data are relevant for the design of clinical trials using adenoviral vectors encoding HSV-tk...
- Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled studySambit Sen
Liver Failure Group, Institute of Hepatology, University College London, London, UK
Liver Transpl 10:1109-19. 2004The pathophysiological basis of acute-on-chronic liver failure (ACLF) is unclear but systemic inflammatory response is thought to be important...
- Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigraOmar Cauli
Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Valencia, Spain
J Hepatol 45:654-61. 2006..The underlying mechanisms remain unclear. This work's aims were: (1) to analyse in rats with chronic liver failure due to portacaval shunt (PCS) the neurochemical alterations in the basal ganglia-thalamus-cortex circuits; (2) ..
- High mobility group box-1 protein inhibits regulatory T cell immune activity in liver failure in patients with chronic hepatitis BLu Wen Wang
Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China
Hepatobiliary Pancreat Dis Int 9:499-507. 2010b>Liver failure in chronic hepatitis B (CHB) patients is a severe, life-threatening condition. Intestinal endotoxemia plays a significant role in the progress to liver failure...
- Liver failure after major hepatic resectionGiuseppe Garcea
Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA, Australia
J Hepatobiliary Pancreat Surg 16:145-55. 2009The consequence of excessive liver resection is the inexorable development of progressive liver failure characterised by the typical stigmata associated with this condition, including worsening coagulopathy, hyperbilirubinaemia and ..
- The superoxide dismutase mimetic MnTBAP prevents Fas-induced acute liver failure in the mouseB Malassagne
Laboratoire d'Immunologie, , , 75679 Paris Cedex 14, France
Gastroenterology 121:1451-9. 2001BACKGROUND & AIMS: Acute liver failure (ALF) of viral origin results from massive hepatocyte apoptosis induced by the interaction between Fas expressed on hepatocytes and Fas ligand on activated T lymphocytes...
- Do antinuclear antibodies in primary biliary cirrhosis patients identify increased risk for liver failure?Wei Hong Yang
Center for Immunology and Inflammatory Diseasese, Massachusetts General Hospital, Boston, MA 02129, USA
Clin Gastroenterol Hepatol 2:1116-22. 2004..Identification of serologic markers associated with increased risk of liver failure would assist in management of PBC patients...
- Antiviral treatment of recurrent hepatitis C after liver transplantation: predictors of response and long-term outcomeNazia Selzner
Multi Organ Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada
Transplantation 88:1214-21. 2009..Efficacy and long-term outcome of antiviral therapy for recurrent hepatitis C after liver transplantation is poorly defined...
- Hepatitis C infection in liver transplantationM Charlton
Department of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Am J Transplant 1:197-203. 2001Hepatitis C-associated liver failure is the most common indication for liver transplantation and recurs nearly universally following transplantation...
- Biliary complications following liver transplantation in the model for end-stage liver disease era: effect of donor, recipient, and technical factorsTheodore H Welling
Division of Transplantation, University of Michigan Medical Center, Ann Arbor, MI, USA
Liver Transpl 14:73-80. 2008..Donor, recipient, and technical factors appear to differentially affect the incidence of anastomotic biliary complications, with warm ischemia, use of HTK, and use of a stent emerging as the most important variables...
- Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancyH A Lemonde
Biochemistry, Endocrinology, and Metabolism Unit, Institute of Child Health, University College London with Great Ormond Street Hospital for Children NHS Trust, London, UK
Gut 52:1494-9. 2003..It has been proposed that some (but not all) of these have mutations in the gene encoding delta(4)-3-oxosteroid 5beta-reductase (SRD5B1; AKR1D1, OMIM 604741)...
- Phosphatidylcholine homeostasis and liver failureZhaoyu Li
Department of Biochemistry, University of Alberta, Edmonton, Canada
J Biol Chem 280:37798-802. 2005..The ability of Mdr2(-/-)/Pemt(-/-) mice to survive complete choline deprivation suggests that acute lethality in CD-Pemt(-/-) mice results from rapid depletion of hepatic PC via biliary secretion...
- Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failureKei Sawara
First Department of Internal Medicine, Iwate Medical University, Morioka, Japan
Neurochem Int 55:119-23. 2009There is evidence to suggest that integrity of the neurovascular unit may be compromised in acute liver failure (ALF)...
- Is coeliac disease a potentially treatable cause of liver failure?Fiona M Stevens
Department of Medicine, National University of Galway, Galway, Ireland
Eur J Gastroenterol Hepatol 17:1015-7. 2005..Of particular note are the 13 patients reported to date with liver failure and coeliac disease...
- A model to determine 3-month mortality risk in patients with acute-on-chronic hepatitis B liver failureMing Hua Zheng
Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
Clin Gastroenterol Hepatol 9:351-356.e3. 2011b>Liver failure has high mortality. There are accurate but controversial models to determine mortality of patients with acute-on-chronic hepatitis B liver failure (ACHBLF)...
- Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failureImir G Metushi
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Hepatology 59:1084-93. 2014..hepatotoxicity remains one of the most common causes of drug-induced idiosyncratic liver injury and liver failure. This form of liver injury is not believed to be immune-mediated because it is not usually associated with ..
- Value of general surgical risk models for predicting postoperative liver failure and mortality following liver surgeryYoshio Haga
Institute for Clinical Research, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
J Surg Oncol 106:898-904. 2012..This study evaluated the ability of general surgical models to predict postoperative morbidity and mortality in liver surgery...
- [Adult-onset Still's disease with liver failure requiring liver transplantation]Alvaro Terán
Servicio de Aparato Digestivo, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
Gastroenterol Hepatol 32:681-6. 2009We present the case of a 23-year-old man with fever of unknown origin, who developed acute liver failure 2 months after symptom onset, requiring an urgent liver transplantation...
- Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantationHideo Nagata
Department of Surgery, University of Nebraska Medical Center, Omaha 68198, USA
Gastroenterology 124:422-31. 2003..The use of porcine hepatocytes might address this problem; however, xenogeneic hepatocytes are thought to be functionally incompatible across species and susceptible to irreversible rejection...
- Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombinationToshinori Totsugawa
Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
J Hepatol 47:74-82. 2007..Hepatocyte transplantation and bioartificial liver treatment are attractive alternatives to liver transplantation. The availability of well-characterized human hepatocyte lines facilitates such cell therapies...
- Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failureMukaddes Esrefoglu
Mukaddes Esrefoglu, Department of Histology and Embryology, Medical Faculty, Bezmialem Vakif University, 34093 Istanbul, Turkey
World J Gastroenterol 19:6757-73. 2013Although the liver has a high regenerative capacity, as a result of massive hepatocyte death, liver failure occurs...
- Brain edema in acute liver failure and chronic liver disease: similarities and differencesCristina R Bosoi
Neuroscience Research Unit, Hôpital Saint Luc CRCHUM, Universite de Montreal, Quebec, Canada
Neurochem Int 62:446-57. 2013Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that typically develops as a result of acute liver failure or chronic liver disease. Brain edema is a common feature associated with HE...
- Sera from liver failure patients and a demethylating agent stimulate transdifferentiation of murine bone marrow cells into hepatocytes in coculture with nonparenchymal liver cellsShintaro Yamazaki
Third Department of Surgery, Nihon University School of Medicine, Tokyo, Japan
J Hepatol 39:17-23. 2003..In the present study we investigated the effects of liver nonparenchymal cells (NPCs) and sera from liver failure patients (HSLF) on the in vitro transdifferentiation of murine BMCs into hepatocytes.
- 1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shockF A Santos
Department of Physiology and Pharmacology, , Fortaleza, Brazil
J Pharm Pharmacol 53:505-11. 2001....
- [Etiological analysis of 1977 patients with acute liver failure, subacute liver failure and acute-on-chronic liver failure]Xiao Yan Liu
Chinese PLA Postgraduate Medical School, Beijing 100039, China
Zhonghua Gan Zang Bing Za Zhi 16:772-5. 2008..To investigate the etiology of 1977 patients from northern China with acute (ALF), sub-acute (SALF) or acute-on-chronic liver (ACLF) failures...
- NASH-related liver failure: one hit too many?Christopher P Day
Am J Gastroenterol 97:1872-4. 2002
- Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tensionArun Kundra
Department of Medicine, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi 110002, India
Clin Biochem 38:696-9. 2005The present study was designed to (a) evaluate and compare plasma ammonia levels (PAL) in patients with acute liver failure (ALF) and chronic liver disease (CLD) with or without hepatic encephalopathy (HE); (b) correlate the severity of ..
- Development of a sensitive prognostic scoring system for the evaluation of severity of acute-on-chronic hepatitis B liver failure: a retrospective cohort studyYu Bao Zheng
Department of Infectious Diseases, The Third Affilliated Hospital, Sun Yat Sen University, Guangzhou City, 510630 PR China
Clin Invest Med 35:E75-85. 2012The purpose of the current study was to establish an objective, simple, and sensitive prognostic scoring system for estimating the severity of acute-on-chronic liver failure in hepatitis B (ACLFB).
- Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in ratsPeter Recknagel
Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany
Liver Int 33:283-93. 2013Many of the concepts describing molecular mechanisms of sepsis-induced liver failure are derived from endotoxin models...
- Liver failure after major liver resection: risk assessment by using preoperative Gadoxetic acid-enhanced 3-T MR imagingAndreas Wibmer
From the Departments of Radiology A W, R N, A B S and Surgery A M P, T G, M S, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Radiology 269:777-86. 2013..if gadoxetic acid-enhanced magnetic resonance (MR) imaging with measurement of relative liver enhancement (RLE) on hepatobiliary phase images can allow preoperative assessment of the risk of liver failure after major liver resection.
- Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failureVairappan Balasubramaniyan
Liver Failure Group, UCL Institute for Liver and Digestive Health, Royal Free Hospital, Pond Street, London NW3 2PF, UK
J Hepatol 58:1194-200. 2013In cirrhosis, superimposed inflammation often culminates in acute-on-chronic liver failure (ACLF) but the mechanism underlying this increased sensitivity is not clear...
- p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failureJan Heinrichsdorff
Institute for Genetics, Centre for Molecular Medicine CMMC, and Cologne Excellence Cluster on Cellular Stress Responses in Aging associated Diseases CECAD, University of Cologne, Zülpicher Str 47, D 50674 Cologne, Germany
EMBO Rep 9:1048-54. 2008..By contrast, LPS injection caused liver failure in mice lacking both p38alpha and IkappaB kinase 2 (IKK2) in hepatocytes...
- Early renal function post-liver transplantation is predictive of progressive chronic kidney diseaseGustaf Herlenius
Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
Scand J Gastroenterol 43:344-9. 2008....
- Liver failure in a dog following suspected ingestion of blue-green algae (Microcystis spp.): a case report and review of the toxinLionel Sebbag
Veterinary Health Center, Kansas State University, Manhattan, KS, USA
J Am Anim Hosp Assoc 49:342-6. 2013..Ingestion is typically fatal for most patients. This is the first canine to be reported in the literature to survive treatment after known exposure. ..
- Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regenerationKuno Lehmann
Swiss Hepato Pancreatico Biliary Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
Gastroenterology 143:1609-1619.e4. 2012..We developed a mouse model to assess the regenerative capacity of a critically small liver remnant...
- A model to predict 3-month mortality risk of acute-on-chronic hepatitis B liver failure using artificial neural networkM H Zheng
Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
J Viral Hepat 20:248-55. 2013..The aim of this study was to predict 3-month mortality risk of acute-on-chronic hepatitis B liver failure (ACHBLF) on an individual patient level using an artificial neural network (ANN) system...
- Epidemiological and clinical features of hepatitis B virus related liver failure in ChinaChen Liu
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
World J Gastroenterol 17:3054-9. 2011To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China.
- Lipid peroxidation in acute respiratory distress syndrome and liver failureChristoph Lichtenstern
Department of Anesthesiology and Intensive Care Medicine, University Hospital Giessen and Marburg, Giessen, Germany
J Surg Res 168:243-52. 2011..to investigate differences in LPO pattern of patients with established acute respiratory distress syndrome (ARDS) and patients with end-stage liver failure undergoing liver transplantation (LTX) as two mayor prototypes of organ failure.
- A novel ATP7B gene mutation in a liver failure patient with normal ceruloplasmin and low serum alkaline phosphataseLi Chen
Department of Hepatology, Infectious Disease Hospital, Fujian Medical University, Fuzhou, China
Gene 538:204-6. 2014..We present a liver failure patient, who was misdiagnosed for two years, with normal ceruloplasmin and low serum alkaline phosphatase...
- Trastuzumab plus estrogen suppression as salvage treatment in a case of liver failure due to metastatic breast cancerAndrea A Martoni
Medical Oncology Unit, S Orsola Malpighi Hospital, Bologna, Italy
Anticancer Res 26:3739-44. 2006b>Liver failure associated with metastatic breast cancer is a short-term survival condition in which standard chemotherapy is almost always contraindicated.
- RAGE blockade and hepatic microcirculation in experimental endotoxaemic liver failureA Kuhla
Institute for Experimental Surgery, University of Rostock, Rostock, Germany
Br J Surg 100:1229-39. 2013..Therefore, RAGE has potential as a new therapeutic target in sepsis. The aim of this study was to analyse whether RAGE blockade in vivo prevents microcirculatory dysfunction and subsequent tissue injury in endotoxaemic liver failure.
- [A prospective cohort study on the influence of high doses of herbs for clearing heat and resolving stasis on survival rates in patients with hepatitis B-related acute-on-chronic liver failure]Xiao Yu Hu
Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
Zhong Xi Yi Jie He Xue Bao 10:176-85. 2012Hepatitis B-related acute-on-chronic liver failure (ACLF) is a severe clinical syndrome characterized by jaundice, coagulopathy, ascites and hepatic encephalopathy and with a high mortality rate of 65% to 93%...
- Cirrhosis and liver failure in nonalcoholic fatty liver disease: Molehill or mountain?Michael Charlton
Hepatology 47:1431-3. 2008
- Predictive parameters after molecular absorbent recirculating system treatment integrated with model for end stage liver disease model in patients with acute-on-chronic liver failureG Novelli
Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
Transplant Proc 42:1182-7. 2010..Two homogenous groups were studied: one treated with standard medical therapy (SMT) and the other, with MARS...
- Altered fasting and postprandial plasma ghrelin levels in patients with liver failure are normalized after liver transplantationMaria Teresa Diz-Lois
Department of Gastroenterology, University Hospital A Coruña Xubias de Arriba 84, Coruna, Spain
Eur J Endocrinol 163:609-16. 2010Anorexia is a problem of paramount importance in patients with advanced liver failure. Ghrelin has important actions on feeding and weight homeostasis. Experimental data exist, which suggest that ghrelin could protect hepatic tissue...
- Liver failure due to antithyroid drugs: report of a case and literature reviewSarantis Livadas
First Department of Internal Medicine, Laiko General Hospital, Medical School, University of Athens, Athens, Greece
Endocrine 38:24-8. 2010..These agents may cause severe adverse effects and among them liver failure, although rare, is a potential lethal one...
- Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failureRegina Rodrigo
Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Valencia, Spain
J Neurochem 102:51-64. 2007..of this pathway and of nitric oxide synthase (NOS) are altered in cerebral cortex in vivo in rats with chronic liver failure due to portacaval shunt (PCS) and whether these alterations are due to hyperammonemia...
- [Muscle weakness and early stages of liver failure in a 22-year-old man]D Scheicht
Klinik für Rheumatologie, Krankenhaus Porz am Rhein, Akademisches Lehrkrankenhaus der Universitätsklinik Köln, Urbacher Weg 19, 51149, Koln, Deutschland
Internist (Berl) 54:1016-22. 2013..The course of disease was complicated by liver failure and severe pneumonia requiring ventilatory assistance...
- Mortality rate of alcoholic liver disease and risk of hospitalization for alcoholic liver cirrhosis, alcoholic hepatitis and alcoholic liver failure in Australia between 1993 and 2005W Liang
National Drug Research Institute, Curtin University, Perth, Western Australia, Australia
Intern Med J 41:34-41. 2011..The aim of this study was to investigate recent trends in hospital admission rates among alcoholic liver cirrhosis, alcoholic hepatic failure and alcoholic hepatitis in Australia, as well as the mortality of ALD...
- Liver failure and need for liver transplantation in patients with advanced hepatoportal sclerosisM Isabel Fiel
The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA
Am J Surg Pathol 31:607-14. 2007..In conclusion, HPS can cause hepatic synthetic dysfunction that may necessitate LT. Small liver volume, significant portal fibrosis, and phlebosclerosis may contribute to hepatic parenchymal loss and subsequent synthetic compromise...
- Amelioration of liver injury by continuously targeted intervention against TNFRp55 in rats with acute-on-chronic liver failureYumin Xu
Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
PLoS ONE 8:e68757. 2013Acute-on-chronic liver failure (ACLF) is an acute deterioration of established liver disease...
- Dissection of the intracellular pathways in hepatocytes suggests a role for Jun kinase and IFN regulatory factor-1 in Con A-induced liver failureK Streetz
Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
J Immunol 167:514-23. 2001..Cytokines are important to determine the outcome of liver failure in this model, and especially TNF-alpha and IFN-gamma directly contribute to hepatocyte damage...
- Recombinant human growth hormone increases albumin and prolongs survival in patients with chronic liver failure: a pilot open, randomized, and controlled clinical trialN Li
Department of GI and Hepatology, Beijing You an Hospital Affiliated to Capital Medical University, China
Dig Liver Dis 40:554-9. 2008To evaluate the efficacy and safety of recombinant human growth hormone (rhGH) in the treatment of patients with chronic liver failure.
- Nursing care of chronic and acute liver failureSarah Starr
Princess Alexandra Hospital, Harlow, Essex
Nurs Stand 16:47-54; quiz 55-6. 2002The authors describe the structure and functions of the liver, as well as the main causes and symptoms of chronic and acute liver failure. The nursing assessment and management of patients with liver disease are also examined.
- Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesisQiuning Bu
Department of Microbiology, School of Basic Medical Sciences, Peking University Infectious Disease Center, Peking University, Beijing 100191, China
Arch Virol 158:165-72. 2013..of a genotype 4 strain of Hepatitis E virus (HEV) (CHN-NJ-H2011) from a patient (in Nanjing, China) with liver failure has been determined. Phylogenetic analysis showed that CHN-NJ-H2011 belongs to genotype 4, subtype 4h...
- The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthaseJ Nikolic
Department of Biochemistry, School of Medicine, University of Nis, Nis, Serbia and Montenegro
Amino Acids 32:127-31. 2007..Results obtained in this study show that mercury chloride-induced toxicity leads to abnormally high levels of ALT and AST that may indicate liver damage with the involvement of polyamine catabolic enzymes and NO...
- Albumin dialysis with molecular adsorbent recirculating system (MARS) for the treatment of hepatic encephalopathy in liver failureRamón A Kobashi-Margáin
Medica Sur Clinic and Foundation, Biomedical Research Department, Liver Research Unit, Mexico City Mexico
Ann Hepatol 10:S70-6. 2011..Hepatic encephalopathy is a common neuropsychiatric syndrome that usually accompanies liver failure and impacts greatly on the quality of life...
- The neurology of liver failureM Lewis
Academic Unit of Medicine, St James s University Hospital, Leeds, UK
QJM 96:623-33. 2003
- Liver transplantation and hepatitis CM Willems
Department of Gastroenterology, University Hospital Dijkzigt, P O Box 2040, 3000 Rotterdam, The Netherlands
Transpl Int 15:61-72. 2002..of a hepatitis C infection and concomitant disease in the liver graft may cause substantial morbidity, end-stage liver disease and liver failure caused by a chronic hepatitis C infection remain good indications for liver transplantation.
- Association of cytomegalovirus infection and disease with recurrent hepatitis C after liver transplantationWendelyn Bosch
Division of Infectious Diseases, Mayo Clinic in Florida, Jacksonville, FL, USA
Transplantation 93:723-8. 2012..Cytomegalovirus (CMV) has been inconsistently associated with recurrent hepatitis C virus (HCV) after liver transplant (LT)...
- Anti-HBs-positive liver failure due to hepatitis B virus reactivation induced by rituximabToshiki Sera
Ehime University Graduate School of Medicine, Department of Gastroenterology and Metabology, Shitsukawa, Toon
Intern Med 45:721-4. 2006..Rituximab appears likely to have induced HBV reactivation in this case. Anti-viral agents should be administered for both HBsAg-positive and anti-HBs-positive patients who are scheduled to receive rituximab...
- Risk factors for liver failure and mortality after hepatectomy associated with portal vein resectionPhilippe Bachellier
Centre de Chirurgie Viscerale et de Transplantation, Hôpitaux Universitaires de Strasbourg Université Louis Pasteur, Strasbourg, France
Ann Surg 253:173-9. 2011To report the postoperative outcome of hepatectomy associated with portal vein resection (PVR) and to identify risk factors of clinical value for predicting postoperative liver failure and mortality.
- Serum acute-phase protein level as indicator for liver failure after liver resectionPascal Ananian
Department of Surgery and Liver Transplantation, Hopital de la Conception, Marseille, France
Hepatogastroenterology 52:857-61. 2005We investigated the relationship between postoperative liver failure and serum acute-phase protein level before and after liver resection.
- Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic DiseasStephen C Strom; Fiscal Year: 2010..deficient in the tyrosine catabolic enzyme, fumarylacetoacetate hydrolase (Fah -/-) and develop irreversible liver failure if left untreated...
- Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, ObesitRobert A Harris; Fiscal Year: 2012..in which inflammation kills liver cells, ultimately culminating in liver cirrhosis, portal hypertension, and liver failure. Although NASH is less prevalent (about a quarter of the population with NAFLD have NASH), the number is ..
- Pathogenesis and Treatment of Liver Disease in Transaldolase DeficiencyAndras Perl; Fiscal Year: 2013..provided by applicant): Although oxidative stress is implicated in both acute acetaminophen-induced liver failure and chronic liver diseases, cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic ..
- Natural History and Prevention of Viral Hepatitis Among Alaska NativesBRIAN JAMES MCMAHON; Fiscal Year: 2013..Hepatitis B virus (HBV) can cause chronic infection, resulting in cirrhosis of the liver, liver cancer, liver failure, and death...
- Novel diagnostic and safety biomarkers of liver injury and hepatotoxicityStanislav I Svetlov; Fiscal Year: 2010..liver diseases, including viral hepatitis, alcoholic liver disease or hepatic cancer, which frequently lead to liver failure and requires liver transplantation...
- Nanoemulsion-based vaccine for chronic hepatitis B virusJames R Baker; Fiscal Year: 2010..are chronically infected with HBV leading to nearly one million deaths annually as a result of cirrhosis, liver failure and hepatocellular carcinoma (HCC)...
- Novel Therapy for PreeclampsiaJames W Larrick; Fiscal Year: 2012..Digibind was effective for PE in a clinical trial. We will develop a novel human monoclonal antibody with higher specificity than Digibind for MBG. This innovative therapeutic humAb will be the first effective treatment of PE. ..
- Role of Platelet derived growth factor receptor-a in Liver Patho-biologySATDARSHAN SINGH MONGA; Fiscal Year: 2013..Cirrhosis can be further complicated by liver failure, portal hypertension and development of hepatocellular cancer (HCC), making chronic liver disease as the 12th ..
- Optical Molecular Tomography for Regenerative MedicineGe Wang; Fiscal Year: 2013..diseases, stroke, degenerative neurological diseases, diabetes, arthritis, osteoporosis, kidney and liver failure, spinal cord injury, burns, battlefield trauma, and other devastating conditions...
- The Role of Alcohol in HIV Therapy HepatotoxicityCraig J McClain; Fiscal Year: 2012..Here, we will study hepatotoxicity due to alcohol/HAART interactions to further define disease mechanisms and create therapeutic interventions. ..
- Modifiers of hepcidin expression as new therapies for iron overloadPAULA GOODMAN FRAENKEL; Fiscal Year: 2013DESCRIPTION (provided by applicant): Iron overload syndromes remain important causes of heart and liver failure in patients with thalassemia or hereditary hemochromatosis, which are common genetic diseases worldwide...
- Deriving hepatocytes from disease specific iPS to treat metabolic liver disordersNamita Roy-Chowdhury; Fiscal Year: 2013..is being developed as a minimally invasive alternative to liver transplantation for patients with liver failure or inherite metabolic disorders...
- UT GASTROENTEROLOGY / HEPATOLOGY RESEARCH TRAINING PROGRAMEzra Burstein; Fiscal Year: 2013..liver steatosis, lipid metabolism and gallstone disease;immune responses in the liver and acute liver failure;hepatic fibrosis and portal hypertension;and, viral hepatitis and anti-viral immunity...
- Excessive Copper Levels Disrupt Hepatic Nuclear Receptor FunctionClavia Ruth Wooton-Kee; Fiscal Year: 2011..ATPase, ATP7b, and is associated with a variety of symptoms including steatosis, cholestasis, cirrhosis, and liver failure, as well as neurological dysfunction...
- Safety and PK Study in Hepatic Impairment PatientsWeizhong Cai; Fiscal Year: 2010..B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis, liver failure and death...
- Sterile Hepatic InflammationWajahat Zafar Mehal; Fiscal Year: 2012..In addition this also results in increased mortality due to cirrhosis, hepatocellular cancer as well as liver failure. Currently there are no effective treatments these liver diseases...
- Novel Small Molecule Therapeutics to Treat ObesitySUSAN MEDGHALCHI; Fiscal Year: 2010..and Type II diabetes, and non- alcoholic steatohepatitis (NASH), which may progress to cirrhosis and liver failure. GPAT (glycerol-3- phosphate acyltransferase) is the initial committed step in acylglycerol synthesis and has ..
- Colorado Center for Childhood Liver Disease Research and EducationRonald J Sokol; Fiscal Year: 2013..fat-soluble vitamin malabsorption;and progressive hepatic fibrosis, portal hypertension and eventually chronic liver failure. Investigation of these disorders promises to advance scientific knowledge about liver development, ..
- Novel Small Molecules For Acute Liver FailurePrakash Narayan; Fiscal Year: 2009DESCRIPTION (provided by applicant): Acute liver failure (ALF) constitutes a challenge to clinicians and scientists alike...
- Dichotomous Roles of Thrombin in Acetaminophen HepatotoxicityROBERT ANDREW ROTH; Fiscal Year: 2013DESCRIPTION (provided by applicant): Overdose with acetaminophen (APAP) is the most common cause of acute liver failure in humans...
- NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver FailureMICHAEL DAVID NORENBERG; Fiscal Year: 2012..provided by applicant): Brain edema and associated intracranial hypertension are major complications of acute liver failure (ALF), which has a high mortality and for which therapeutic options are largely limited to an emergency liver ..
- Developing Novel Serological Biomarkers for Autoimmune Liver DiseasesXuhang Li; Fiscal Year: 2013..AILDs result in marked suffering and serious consequences of AILDs lead to liver failure and hepatobiliary malignancy...
- Mechanisms of ER stress - induced fatty liverD Thomas Rutkowski; Fiscal Year: 2013..steatohepatitis that compromises liver function, leading to inflammation, fibrosis, cirrhosis, and ultimately liver failure. While FLD most likely reflects an imbalance between lipid synthesis, storage, oxidation, and/or secretion, ..
- Nrf2 as a Master Regulator in Liver Disease Prevention and TherapyCurtis D Klaassen; Fiscal Year: 2012..Liver disease is a common ailment, however in contrast to most other diseases, there are very few drugs for liver failure. We hypothesize that Nrf2, an essential transcription factor, is a drug target that can be used to prevent and ..
- L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicityW Ray Kim; Fiscal Year: 2011..Liver transplantation (LTx) is now well-established as a means of restoring health in patients with liver failure, the 10th leading cause of death in the US...
- Oxygen/Nitrogen Stress in Acetaminophen HepatotoxicityJack A Hinson; Fiscal Year: 2013DESCRIPTION (provided by applicant): Acetaminophen (APAP) poisoning is the most common cause of acute liver failure in the U.S...
- Keratin Biology and Disease Aspects in Simple EpitheliaBishr Omary; Fiscal Year: 2013..iii) Examine the utility of assessing keratin apoptotic fragments in patients with acute liver failure. The hypothesis for Aim#3 is that apoptosis during acute liver injury results in leakage of the highly ..
- Suppression of the Interferon Response by the Hepatitis C VirusFRANCIS VINCENT CHISARI; Fiscal Year: 2010..by HCV in the USA and 170 million people are chronically infected worldwide, many of whom will die from liver failure and hepatocelluar carcinoma...
- ROLE OF WNT SIGNALING IN CHRONIC ALCOHOLIC LIVER DISEASEMiran Kim; Fiscal Year: 2013..stages of steatohepatitis, fibrosis, cirrhosis, and finally end-stage liver disease, which culminates in liver failure. ALD is common, and accounts for 28% of all deaths from liver disease in the USA...
- Recombinant Polymers for Transarterial Chemoembolization of Liver CancerAZADEH POURSAID; Fiscal Year: 2013..have little efficacy and 85% of patients diagnosed with HCC at any stage die within 5 years either from liver failure or metastatic disease...
- Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virusCharles M Rice; Fiscal Year: 2013..Persistent HCV infection can have severe health consequences, including hepatitis, cirrhosis, liver failure, and hepatocellular carcinoma...
- Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRIScott B Reeder; Fiscal Year: 2013..These patients develop cirrhosis and may succumb to liver failure and/or hepatocellular carcinoma, necessitating liver transplant...
- Role for tissue-type plasminogen activator in suppression of hepatic fibrosisLiang I Kang; Fiscal Year: 2013..of a variety of chronic inflammatory liver diseases, and if untreated, will progress into cirrhosis and liver failure. With the dramatic increased prevalence of non-alcoholic fatty liver disease and chronic hepatitis C worldwide,..
- Synergistic actions by multiple Toll-like receptors in alcoholic liver diseaseEkihiro Seki; Fiscal Year: 2013DESCRIPTION (provided by applicant): Chronic alcohol abuse is the major cause of cirrhosis and liver failure in adult patients in the United States...
- Dipstick Assay for Detection of Acetaminophen Protein AdductsLaura P James; Fiscal Year: 2010..APAP toxicity is the most common cause of acute liver failure (ALF) in the United States and Great Britain today...
- Novel prognostic microRNA biomarkers for primary sclerosing cholangitisKris Kowdley; Fiscal Year: 2013..of bile ducts, PSC often progresses to advanced live disease such as cirrhosis, hepatobiliary cancer and liver failure. Without an effective therapeutic option, liver transplantation is currently considered the only curative ..
- FAH-Deficient PigsScott L Nyberg; Fiscal Year: 2011..animal models, which in turn has limited development of new therapies for metabolic liver disorders, acute liver failure, chronic (cirrhotic) liver disease, an hepatocellular carcinoma...
- Liver Inflammation and Injury: Molecular MechanismsMario Chojkier; Fiscal Year: 2013..In acute and chronic liver diseases, through inflammation and injury induce damage to the liver, resulting in liver failure. Excessive liver damage accounts for the significant complications and mortality among the VA population with ..
- Role of HCV Sequence Variation in PathologyJohn E Tavis; Fiscal Year: 2010Chronic Hepatitis C virus (HCV) infection causes hepatitis, cirrhosis, liver failure, and hepatocellular carcinoma. The factors governing the rate of disease progression along this spectrum of pathology are not known...
- Analysis of Fatty Liver in the Framingham Heart Study CohortElizabeth K Speliotes; Fiscal Year: 2012..increase in obesity, many people have fat deposited in their liver that can lead to liver cirrhosis and liver failure;nevertheless, little is known about the genetic epidemiology or metabolic consequences of fatty liver. Dr...
- Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema MonitoringWilliam F Weitzel; Fiscal Year: 2013..status for a number of disease states, including chronic kidney disease (CKD), congestive heart failure (CHF), liver failure, and lymphedema...
- Mechanisms of Liver FailureChandrashekhar R Gandhi; Fiscal Year: 2013DESCRIPTION (provided by applicant): Acute liver failure (ALF), a devastating condition that affects patients with and without prior liver disease, has a mortality rate of 80% (>20,000 deaths/year in the USA)...
- Drs2p Function in Clathrin-coated Vesicle BuddingTodd R Graham; Fiscal Year: 2013..in the bile canalicular membrane leads to damage of this membrane by secreted bile, ultimately leading to liver failure. P4-ATPase deficiency in mice is linked to diet induced obesity and type 2 diabetes (Atp10a and Atp10d) as ..
- A Novel Therapeutic Approach for Liver InjuryXiaoling Qiang; Fiscal Year: 2010..provided by applicant): Liver injury induced by hepatic ischemia and reperfusion (I/R) is a major cause of liver failure after severe trauma, thermal injury, hemorrhagic and septic shock, liver resection, or liver transplantation...
- LIPIN 1 IN THE REGULATION OF HEPATIC LIPID METABOLISMBrian N Finck; Fiscal Year: 2013..Although steatohepatitis can progress to cirrhosis and liver failure, the most common co-morbidity of NAFLD is hepatic insulin resistance and systemic abnormalities in circulating ..
- Ah Receptor Anatomy: Implications for Dioxin ToxicityCORNELIS JOHAN ELFERINK; Fiscal Year: 2011..Dysregulation in the repair process can lead o liver failure or liver cancer...
- Designing a Microenvironment Niche for Liver-Specific Differentiation of hESCsAlexander Revzin; Fiscal Year: 2013..However, the number of donor livers is severely inadequate and a large fraction of patients with liver failure do not receive a donor organ...
- Improved liver function and regeneration with A20Christiane Ferran; Fiscal Year: 2013..Demonstrating A20's beneficial effects in our experimental models should set the basis for translating A20- based therapies into clinical practice. ..
- Cellular Mechanisms of Hepatotoxicity.Neil Kaplowitz; Fiscal Year: 2013DESCRIPTION (provided by applicant): Acetaminophen (APAP) toxicity is the leading cause of acute liver failure. The mouse model of APAP hepatotoxicity is highly reproducible and widely utilized to elucidate the mechanisms of liver ..
- Liver innate immunity in drug-induced liver disease.Zhang Xu Liu; Fiscal Year: 2012..provided by applicant): Acetaminophen (APAP) hepatotoxicity is currently the most common cause of acute liver failure in the United States...
- Autophagy in liver injuryJae Sung Kim; Fiscal Year: 2013..into lethal I/R injury to liver, and will establish novel therapeutic approaches for improving I/R-mediated liver failure. PUBLIC HEALTH RELEVANCE: Impairment of blood flow causes a tissue ischemia and recovery of blood flow causes ..
- PDGFR and KDR Inhibitors for Liver FibrosisBert Oehlen; Fiscal Year: 2010..B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis, liver failure and death...
- Integrating plasma IGF-1 into novel classification of hepatocellular carcinomaAhmed Kaseb; Fiscal Year: 2013..This selection criterion facilitates assessment of the effect of treatment without the confounding issues of liver failure and death as a result of underlying cirrhosis...
- Circulating miRNA as a biomarker for biliary atresiaJoshua R Friedman; Fiscal Year: 2013..If untreated, the disease uniformly progresses to biliary cirrhosis, liver failure, and death within 2 years...
- LPS binding to TLR4 regulates hepatic stellate cell activation and fibrosisEkihiro Seki; Fiscal Year: 2013..viral hepatitis, autoimmune diseases, and non- alcoholic steatohepatitis (NASH), can progress to cirrhosis, liver failure, portal hypertension, and hepatocellular carcinoma...
- Hepatitis C Clinical Trial-Clinical CenterJules L Dienstag; Fiscal Year: 2009..with chronic hepatitis C who do not respond to antiviral treatment are at risk of progression to cirrhosis, liver failure, hepatocellular carcinoma (HCC) and death...
- Biomarker for liver ischemia/reperfusion-induced injuryMONIKA OLI; Fiscal Year: 2006..Liver injury induced by hepatic ischemia followed by reperfusion is a major pathogenic cause of liver failure during multiple trauma, thermal injury, hemorrhagic and septic shock, and liver transplantation, which ..
- Open-Source Informatics Used to Improve Outcomes in Pediatric Liver TransplantsSTEVEN PETER BUCUVALAS; Fiscal Year: 2010DESCRIPTION (provided by applicant): Twenty-five years ago, a two-year old with liver failure had no medical or surgical options for survival...
- DEVELOPMENT OF A NOVEL BIOARTIFICIAL LIVERJacek Rozga; Fiscal Year: 2002ARBIOS developed a novel hybrid bioartificial live r(HyBAL) to treat patients with liver failure of various etiologies...
- 2010 Molecular Biology of Hepatitis B Viruses MeetingAdam Zlotnick; Fiscal Year: 2010..Chronic HBV contributes to the deaths of some 600,000 people annually mainly by liver failure, cirrhosis, and hepatocellular carcinoma...
- Serologic test for neonatal hemochromatosis in infants with acute liver failurePETER FRANK WHITINGTON; Fiscal Year: 2010..This application specifically seeks to develop an approach that will improve the diagnosis of acute liver failure in infants, result in significantly improved outcome with medical therapy, and reduce the utilization of liver ..
- Novel therapeutic for Alcoholic Liver DiseaseBert Oehlen; Fiscal Year: 2009..Liver Disease (ALD) is a progressive liver disease that in advanced stages can result in cirrhosis and liver failure. ALD can be divided in various stages of development: (1) mild alcoholic liver injury, (2) steatosis, (3) ..
- Diagnosing and monitoring NAFLD using unbound FFA profilesAlan Kleinfeld; Fiscal Year: 2009..NAFLD is a progressive disease in which simple steatosis can lead to steatohepatitis, cirrhosis, liver failure and hepatocellular carcinoma...
- SCF in liver repair after hepatectomy or toxic injuryLisa Colletti; Fiscal Year: 2006..b>Liver failure is an important clinical problem that occurs after a variety of toxic, traumatic, and infectious insults...
- HYBRID ARTIFICIAL LIVER USING IMMOBILIZED HEPATOCYTESRonald Tompkins; Fiscal Year: 1991..developed in this work will provide a rational basis for design of treatment modalities for acute and chronic liver failure. The viability and function of the hepatocytes will be examined in the short and long term...
- Engineered 3-D Human Liver Tissue for Hepatitis StudiesBRIAN NAUGHTON; Fiscal Year: 2004..HCV infection of the liver progresses to cirrhosis followed by hepatocellular carcinoma and ultimately liver failure, and is the leading reason for liver transplantation...
- STUDIES OF THE NATURAL HISTORY OF HEPATITIS C IN LIVERRobert Carithers; Fiscal Year: 2002..As a consequence, liver failure from chronic hepatitis C has become the leading indication for liver transplantation both in the United States ..