liver failure

Summary

Summary: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTIC DEHYDROGENASE; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)

Top Publications

  1. doi Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice
    Iker Uriarte
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, Clinic University of Navarra and CIBERehd, Pamplona, Spain
    Gut 62:899-910. 2013
  2. pmc Caspase 8 small interfering RNA prevents acute liver failure in mice
    Lars Zender
    Department of Gastroenterology, Medical School Hannover, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 100:7797-802. 2003
  3. doi Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure
    Yong Zou
    Department of Infectious Disease, Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Immunol 184:466-75. 2010
  4. doi Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1
    Joydeep Das
    Division of Molecular Medicine, Bose Institute, P 1 12, CIT Scheme VII M, Kolkata 700054, India
    Free Radic Res 44:340-55. 2010
  5. ncbi Strategies for safer liver surgery and partial liver transplantation
    Pierre Alain Clavien
    Swiss Hepato Pancreatico Biliary HPB Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    N Engl J Med 356:1545-59. 2007
  6. doi Prediction of the prognosis of patients with acute-on-chronic hepatitis B liver failure using the model for end-stage liver disease scoring system and a novel logistic regression model
    Q F Sun
    Department of Infectious Diseases, The Third Affiliated Hospital of Wenzhou Medical College, Rui an, Zhejiang, China
    J Viral Hepat 16:464-70. 2009
  7. doi Alginate-encapsulated HepG2 cells in a fluidized bed bioreactor maintain function in human liver failure plasma
    Sam M Coward
    Centre for Hepatology, Royal Free Hospital and UCL Medical School, London, UK
    Artif Organs 33:1117-26. 2009
  8. doi Nucleoside analogue can improve the long-term prognosis of patients with hepatitis B virus infection-associated acute on chronic liver failure
    Yao Li Cui
    Center of Infectious Diseases, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China
    Dig Dis Sci 55:2373-80. 2010
  9. doi Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome
    Ivan R Diamond
    The Hospital for Sick Children, Toronto, Canada
    J Pediatr Gastroenterol Nutr 48:209-15. 2009
  10. ncbi Impact of pretransplant MELD score on posttransplant outcome in orthotopic liver transplantation for patients with acute-on-chronic hepatitis B liver failure
    Z X Wang
    Liver Transplantation Division, Department of Surgery, West China Hospital, Sichuan University Medical School, Chengdu 610041, Sichuan, China
    Transplant Proc 39:1501-4. 2007

Detail Information

Publications382 found, 100 shown here

  1. doi Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice
    Iker Uriarte
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, Clinic University of Navarra and CIBERehd, Pamplona, Spain
    Gut 62:899-910. 2013
    ..We evaluated the relevance of Fgf15 in the preservation of BA homeostasis after PH and its potential role in the regenerative process...
  2. pmc Caspase 8 small interfering RNA prevents acute liver failure in mice
    Lars Zender
    Department of Gastroenterology, Medical School Hannover, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 100:7797-802. 2003
    A major concern in therapy of acute liver failure is protection of hepatocytes to prevent apoptosis and maintain liver function. Small interfering RNA (siRNA) is a powerful tool to silence gene expression in mammalian cells...
  3. doi Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure
    Yong Zou
    Department of Infectious Disease, Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Immunol 184:466-75. 2010
    ..NK cells in the development of hepatocyte necrosis in fulminant hepatic failure (FHF) and acute-on-chronic liver failure (ACLF) because of viral infection...
  4. doi Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1
    Joydeep Das
    Division of Molecular Medicine, Bose Institute, P 1 12, CIT Scheme VII M, Kolkata 700054, India
    Free Radic Res 44:340-55. 2010
    ..Taurine possesses prophylactic as well as therapeutic potentials against APAP-induced hepatic injury...
  5. ncbi Strategies for safer liver surgery and partial liver transplantation
    Pierre Alain Clavien
    Swiss Hepato Pancreatico Biliary HPB Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland
    N Engl J Med 356:1545-59. 2007
  6. doi Prediction of the prognosis of patients with acute-on-chronic hepatitis B liver failure using the model for end-stage liver disease scoring system and a novel logistic regression model
    Q F Sun
    Department of Infectious Diseases, The Third Affiliated Hospital of Wenzhou Medical College, Rui an, Zhejiang, China
    J Viral Hepat 16:464-70. 2009
    ..of the model for end-stage liver disease (MELD) scoring system in patients with acute-on-chronic hepatitis B liver failure (ACLF-HBV), and to establish a new model for predicting the prognosis of ACLF-HBV...
  7. doi Alginate-encapsulated HepG2 cells in a fluidized bed bioreactor maintain function in human liver failure plasma
    Sam M Coward
    Centre for Hepatology, Royal Free Hospital and UCL Medical School, London, UK
    Artif Organs 33:1117-26. 2009
    ..This study investigates their performance in normal and liver failure (LF) human plasma over 6-8 h in a fluidized bed bioreactor...
  8. doi Nucleoside analogue can improve the long-term prognosis of patients with hepatitis B virus infection-associated acute on chronic liver failure
    Yao Li Cui
    Center of Infectious Diseases, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China
    Dig Dis Sci 55:2373-80. 2010
    The prognosis of patients with hepatitis B virus (HBV)-associated acute on chronic liver failure (ACLF) is extremely poor.
  9. doi Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome
    Ivan R Diamond
    The Hospital for Sick Children, Toronto, Canada
    J Pediatr Gastroenterol Nutr 48:209-15. 2009
    ..Parenteral omega-3 fatty acids, such as Omegaven, may benefit patients with pediatric short bowel syndrome (SBS) who develop parenteral nutrition-associated liver disease (PNALD)...
  10. ncbi Impact of pretransplant MELD score on posttransplant outcome in orthotopic liver transplantation for patients with acute-on-chronic hepatitis B liver failure
    Z X Wang
    Liver Transplantation Division, Department of Surgery, West China Hospital, Sichuan University Medical School, Chengdu 610041, Sichuan, China
    Transplant Proc 39:1501-4. 2007
    ..score in comparison with the Child-Turcotte-Pugh (CTP) score to predict short-term postoperative survival and 3-month morbidity among patients with acute-on-chronic hepatitis B liver failure undergoing orthotopic liver transplantation.
  11. doi Adjuvant therapeutic plasma exchange in liver failure: assessments of clinical and laboratory parameters
    Mehmet Bektas
    Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
    J Clin Gastroenterol 42:517-21. 2008
    ..The aim of this study was to analyze the positive effects of TPE on clinical and biochemical parameters of liver failure.
  12. ncbi Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone
    R Rajagopalan
    Takeda Pharmaceuticals North America, Inc, Lincolnshire, IL 60069, USA
    Diabetes Obes Metab 7:161-9. 2005
    The aim of this study was to assess the incidence of liver failure in association with antidiabetic treatment using pioglitazone vs. other oral antidiabetic medications.
  13. doi Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS)
    Nuh N Rahbari
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
    Surgery 149:713-24. 2011
    Posthepatectomy liver failure is a feared complication after hepatic resection and a major cause of perioperative mortality...
  14. pmc Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 198:1707-16. 2003
    ....
  15. ncbi Rituximab-related viral infections in lymphoma patients
    Sercan Aksoy
    Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey
    Leuk Lymphoma 48:1307-12. 2007
    ..Close monitoring for viral infection, particularly HBV and CMV, in patients treated with rituximab should be recommended...
  16. ncbi Cirrhosis and chronic liver failure: part I. Diagnosis and evaluation
    Joel J Heidelbaugh
    Department of Family Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am Fam Physician 74:756-62. 2006
    Cirrhosis and chronic liver failure are leading causes of morbidity and mortality in the United States, with the majority of preventable cases attributed to excessive alcohol consumption, viral hepatitis, or nonalcoholic fatty liver ..
  17. ncbi Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas, Southwestern Medical Center, Dallas, 75390 9151, USA
    Hepatology 40:6-9. 2004
    ..for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year. Data from the U.S...
  18. ncbi Interferon combined with cyclosporine treatment as an effective countermeasure against hepatitis C virus recurrence in liver transplant patients with end-stage hepatitis C virus related disease
    K Inoue
    Showa University Fujigaoka Hospital, Yokohama, Japan
    Transplant Proc 37:1233-4. 2005
    ..We reported here the beneficial effect of combined interferon and cyclosporine treatment for chronic hepatitis C. We recommend this protocol for established HCV-related graft disease...
  19. pmc Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failure
    Alex Hattoum
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hum Pathol 44:743-9. 2013
    ..Recent studies have shown that the same pathways may operate in human liver failure. The growth factor receptors (HGF [hepatocyte growth factor] receptor) and epidermal growth factor receptor ..
  20. doi The systemic inflammatory response syndrome in cirrhotic patients: relationship with their in-hospital outcome
    Massimo Cazzaniga
    Department of Internal Medicine, IRCCS Policlinico San Donato, University of Milan, 20097 San Donato Milanese, Milan, Italy
    J Hepatol 51:475-82. 2009
    ..We studied 141 cirrhotic patients consecutively admitted to a tertiary referral centre assessing prevalence of SIRS and its relationship with in-hospital outcome...
  21. pmc Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure
    Hong Ye
    Department of Hepatology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
    World J Gastroenterol 19:2818-25. 2013
    To assess CD163 expression in plasma and peripheral blood and analyze its association with disease in acute-on-chronic hepatitis B liver failure (ACHBLF) patients.
  22. ncbi A bioartificial liver--state of the art
    Alastair J Strain
    Schools of Biosciences and Medicine, University of Birmingham, and Liver and Hepatobiliary Unit, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
    Science 295:1005-9. 2002
    ..In these devices, patient plasma is circulated extracorporeally through a bioreactor that houses liver cells (hepatocytes) sandwiched between artificial plates or capillaries...
  23. ncbi Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model
    Ichiro Ogushi
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Hepatology 38:335-44. 2003
    ..In conclusion, NF-kappa B/decoy/ODN transfer in vivo effectively suppressed endotoxin-induced fatal liver injury in mice...
  24. ncbi Intestinal endotoxemia as a pathogenetic mechanism in liver failure
    De Wu Han
    Institute of Hepatology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
    World J Gastroenterol 8:961-5. 2002
    ..inflammatory responses, with serious hepatic necrosis, further severe hepatitis and even induces acute liver failure. The milder IETM successively precipitates a cascade, including repeated and persistent hepatocytic impairment ..
  25. doi Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in D-GalN/LPS induced acute liver failure in murine models
    Yan Ling Wu
    College of Pharmacy, Yanbian University, Yanji, 133002, Jilin Province, China
    Chem Biol Interact 188:526-34. 2010
    The hepatoprotective effects and molecular mechanisms of baicalein on acute liver failure induced by d-galactosamine (d-GalN)/lipopolysaccharides (LPS) were investigated in vivo...
  26. ncbi Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    D E Cressman
    Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
    Science 274:1379-83. 1996
    ....
  27. doi Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes
    Liang Peng
    Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Hepatology 54:820-8. 2011
    Our study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after a single transplantation with autologous marrow mesenchymal stem cells (MMSCs)...
  28. doi Artificial and bioartificial liver devices: present and future
    B Carpentier
    UTC, UMR CNRS 6600 Biomechanics and Bioengineering, BP 20529, 60205 Compiegne Cedex, France
    Gut 58:1690-702. 2009
    b>Liver failure is associated with high morbidity and mortality without transplantation. There are two types of device for temporary support: artificial and bioartificial livers...
  29. doi Post-liver transplant cholestatic hepatitis C: a systematic review of clinical and pathological findings and application of consensus criteria
    Tarun K Narang
    Department of Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Liver Transpl 16:1228-35. 2010
    ..We propose that studies on PLTCHC use the consensus criteria for diagnosis and suggest clinical information that should be provided in future studies with the goal of improving our understanding and management of this deadly disease...
  30. ncbi Troglitazone-induced liver failure: a case study
    David J Graham
    Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, HFD 400, Room 15B 32, Rockville, MD 20857, USA
    Am J Med 114:299-306. 2003
    Troglitazone was removed from the U.S. market because its use was associated with an increased risk of liver failure. We evaluated the clinical features of all cases reported to the Food and Drug Administration and estimated the duration ..
  31. doi Factors influencing renal function after liver transplantation. Results from the MOST, an international observational study
    P Burra
    Gastroenterology, Department of Surgical and Gastroenterological Sciences, University Hospital Padova, Padova, Italy
    Dig Liver Dis 41:350-6. 2009
    ..Given organ shortage it should be essential to determine which patients will experience progressive and severe renal dysfunction after liver transplantation (LT)...
  32. doi Prediction value of model for end-stage liver disease scoring system on prognosis in patients with acute-on-chronic hepatitis B liver failure after plasma exchange and lamivudine treatment
    Jian Wu Yu
    Department of Infectious Diseases, Second Affiliated Hospital, Harbin Medical University, Harbin, China
    J Gastroenterol Hepatol 23:1242-9. 2008
    ..liver disease (MELD) scoring system to predict the 3-month prognosis of patients with acute-on-chronic liver failure (ACLF) after plasma exchange (PE) and lamivudine treatment, and studied the predictive factors on the ..
  33. pmc Pig liver xenotransplantation as a bridge to allotransplantation: which patients might benefit?
    Burcin Ekser
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Transplantation 88:1041-9. 2009
    Acute liver failure is a potentially devastating clinical syndrome that, without liver transplantation (Tx), is associated with high mortality...
  34. doi Sorafenib-induced liver failure
    Christoph Schramm
    Am J Gastroenterol 103:2162-3. 2008
  35. doi Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance
    B Ekser
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 10:273-85. 2010
    ..human donor livers leads to a significant mortality in patients with acute-on-chronic or acute (fulminant) liver failure or with primary nonfunction of an allograft...
  36. ncbi Technology insight: artificial extracorporeal liver support--how does Prometheus compare with MARS?
    Peter Krisper
    Universitaetsklinik für Innere Medizin, Abteilung für Nephrologie und Hämodialyse, Graz, Austria
    Nat Clin Pract Nephrol 3:267-76. 2007
    Artificial extracorporeal liver support or 'liver dialysis' has been used in patients with severe liver failure with increasing frequency since the Molecular Adsorbents Recirculating System (MARS), a variant of albumin dialysis, was ..
  37. doi Predicting liver failure following major hepatectomy
    G Garcea
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA 5011, Australia
    Dig Liver Dis 41:798-806. 2009
    ..Published data would not suggest any difference in mortality, morbidity or liver failure rates between these groups...
  38. doi Effective bilirubin reduction by single-pass albumin dialysis in liver failure
    Ussanee Boonsrirat
    Department of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand
    Artif Organs 33:648-53. 2009
    Albumin dialysis is widely accepted as a liver-support technique for patients with liver failure. The Molecular Adsorbent Recirculating System, the widely accepted albumin dialysis technique, has limited use in developing countries ..
  39. ncbi Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion
    Maite Herraiz
    Division of Hepatology and Gene Therapy, University of Navarra, Medical School Pamplona, 31008 Pamplona, Spain
    Hum Gene Ther 14:463-72. 2003
    ..These data are relevant for the design of clinical trials using adenoviral vectors encoding HSV-tk...
  40. ncbi Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study
    Sambit Sen
    Liver Failure Group, Institute of Hepatology, University College London, London, UK
    Liver Transpl 10:1109-19. 2004
    The pathophysiological basis of acute-on-chronic liver failure (ACLF) is unclear but systemic inflammatory response is thought to be important...
  41. ncbi Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra
    Omar Cauli
    Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Hepatol 45:654-61. 2006
    ..The underlying mechanisms remain unclear. This work's aims were: (1) to analyse in rats with chronic liver failure due to portacaval shunt (PCS) the neurochemical alterations in the basal ganglia-thalamus-cortex circuits; (2) ..
  42. ncbi High mobility group box-1 protein inhibits regulatory T cell immune activity in liver failure in patients with chronic hepatitis B
    Lu Wen Wang
    Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Hepatobiliary Pancreat Dis Int 9:499-507. 2010
    b>Liver failure in chronic hepatitis B (CHB) patients is a severe, life-threatening condition. Intestinal endotoxemia plays a significant role in the progress to liver failure...
  43. doi Liver failure after major hepatic resection
    Giuseppe Garcea
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA, Australia
    J Hepatobiliary Pancreat Surg 16:145-55. 2009
    The consequence of excessive liver resection is the inexorable development of progressive liver failure characterised by the typical stigmata associated with this condition, including worsening coagulopathy, hyperbilirubinaemia and ..
  44. ncbi The superoxide dismutase mimetic MnTBAP prevents Fas-induced acute liver failure in the mouse
    B Malassagne
    Laboratoire d'Immunologie, , , 75679 Paris Cedex 14, France
    Gastroenterology 121:1451-9. 2001
    BACKGROUND & AIMS: Acute liver failure (ALF) of viral origin results from massive hepatocyte apoptosis induced by the interaction between Fas expressed on hepatocytes and Fas ligand on activated T lymphocytes...
  45. ncbi Do antinuclear antibodies in primary biliary cirrhosis patients identify increased risk for liver failure?
    Wei Hong Yang
    Center for Immunology and Inflammatory Diseasese, Massachusetts General Hospital, Boston, MA 02129, USA
    Clin Gastroenterol Hepatol 2:1116-22. 2004
    ..Identification of serologic markers associated with increased risk of liver failure would assist in management of PBC patients...
  46. doi Antiviral treatment of recurrent hepatitis C after liver transplantation: predictors of response and long-term outcome
    Nazia Selzner
    Multi Organ Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada
    Transplantation 88:1214-21. 2009
    ..Efficacy and long-term outcome of antiviral therapy for recurrent hepatitis C after liver transplantation is poorly defined...
  47. ncbi Hepatitis C infection in liver transplantation
    M Charlton
    Department of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Transplant 1:197-203. 2001
    Hepatitis C-associated liver failure is the most common indication for liver transplantation and recurs nearly universally following transplantation...
  48. ncbi Biliary complications following liver transplantation in the model for end-stage liver disease era: effect of donor, recipient, and technical factors
    Theodore H Welling
    Division of Transplantation, University of Michigan Medical Center, Ann Arbor, MI, USA
    Liver Transpl 14:73-80. 2008
    ..Donor, recipient, and technical factors appear to differentially affect the incidence of anastomotic biliary complications, with warm ischemia, use of HTK, and use of a stent emerging as the most important variables...
  49. pmc Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy
    H A Lemonde
    Biochemistry, Endocrinology, and Metabolism Unit, Institute of Child Health, University College London with Great Ormond Street Hospital for Children NHS Trust, London, UK
    Gut 52:1494-9. 2003
    ..It has been proposed that some (but not all) of these have mutations in the gene encoding delta(4)-3-oxosteroid 5beta-reductase (SRD5B1; AKR1D1, OMIM 604741)...
  50. ncbi Phosphatidylcholine homeostasis and liver failure
    Zhaoyu Li
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    J Biol Chem 280:37798-802. 2005
    ..The ability of Mdr2(-/-)/Pemt(-/-) mice to survive complete choline deprivation suggests that acute lethality in CD-Pemt(-/-) mice results from rapid depletion of hepatic PC via biliary secretion...
  51. doi Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure
    Kei Sawara
    First Department of Internal Medicine, Iwate Medical University, Morioka, Japan
    Neurochem Int 55:119-23. 2009
    There is evidence to suggest that integrity of the neurovascular unit may be compromised in acute liver failure (ALF)...
  52. ncbi Is coeliac disease a potentially treatable cause of liver failure?
    Fiona M Stevens
    Department of Medicine, National University of Galway, Galway, Ireland
    Eur J Gastroenterol Hepatol 17:1015-7. 2005
    ..Of particular note are the 13 patients reported to date with liver failure and coeliac disease...
  53. doi A model to determine 3-month mortality risk in patients with acute-on-chronic hepatitis B liver failure
    Ming Hua Zheng
    Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
    Clin Gastroenterol Hepatol 9:351-356.e3. 2011
    b>Liver failure has high mortality. There are accurate but controversial models to determine mortality of patients with acute-on-chronic hepatitis B liver failure (ACHBLF)...
  54. doi Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure
    Imir G Metushi
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Hepatology 59:1084-93. 2014
    ..hepatotoxicity remains one of the most common causes of drug-induced idiosyncratic liver injury and liver failure. This form of liver injury is not believed to be immune-mediated because it is not usually associated with ..
  55. doi Value of general surgical risk models for predicting postoperative liver failure and mortality following liver surgery
    Yoshio Haga
    Institute for Clinical Research, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
    J Surg Oncol 106:898-904. 2012
    ..This study evaluated the ability of general surgical models to predict postoperative morbidity and mortality in liver surgery...
  56. doi [Adult-onset Still's disease with liver failure requiring liver transplantation]
    Alvaro Terán
    Servicio de Aparato Digestivo, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
    Gastroenterol Hepatol 32:681-6. 2009
    We present the case of a 23-year-old man with fever of unknown origin, who developed acute liver failure 2 months after symptom onset, requiring an urgent liver transplantation...
  57. ncbi Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation
    Hideo Nagata
    Department of Surgery, University of Nebraska Medical Center, Omaha 68198, USA
    Gastroenterology 124:422-31. 2003
    ..The use of porcine hepatocytes might address this problem; however, xenogeneic hepatocytes are thought to be functionally incompatible across species and susceptible to irreversible rejection...
  58. ncbi Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination
    Toshinori Totsugawa
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    J Hepatol 47:74-82. 2007
    ..Hepatocyte transplantation and bioartificial liver treatment are attractive alternatives to liver transplantation. The availability of well-characterized human hepatocyte lines facilitates such cell therapies...
  59. pmc Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure
    Mukaddes Esrefoglu
    Mukaddes Esrefoglu, Department of Histology and Embryology, Medical Faculty, Bezmialem Vakif University, 34093 Istanbul, Turkey
    World J Gastroenterol 19:6757-73. 2013
    Although the liver has a high regenerative capacity, as a result of massive hepatocyte death, liver failure occurs...
  60. doi Brain edema in acute liver failure and chronic liver disease: similarities and differences
    Cristina R Bosoi
    Neuroscience Research Unit, Hôpital Saint Luc CRCHUM, Universite de Montreal, Quebec, Canada
    Neurochem Int 62:446-57. 2013
    Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that typically develops as a result of acute liver failure or chronic liver disease. Brain edema is a common feature associated with HE...
  61. ncbi Sera from liver failure patients and a demethylating agent stimulate transdifferentiation of murine bone marrow cells into hepatocytes in coculture with nonparenchymal liver cells
    Shintaro Yamazaki
    Third Department of Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Hepatol 39:17-23. 2003
    ..In the present study we investigated the effects of liver nonparenchymal cells (NPCs) and sera from liver failure patients (HSLF) on the in vitro transdifferentiation of murine BMCs into hepatocytes.
  62. ncbi 1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock
    F A Santos
    Department of Physiology and Pharmacology, , Fortaleza, Brazil
    J Pharm Pharmacol 53:505-11. 2001
    ....
  63. ncbi [Etiological analysis of 1977 patients with acute liver failure, subacute liver failure and acute-on-chronic liver failure]
    Xiao Yan Liu
    Chinese PLA Postgraduate Medical School, Beijing 100039, China
    Zhonghua Gan Zang Bing Za Zhi 16:772-5. 2008
    ..To investigate the etiology of 1977 patients from northern China with acute (ALF), sub-acute (SALF) or acute-on-chronic liver (ACLF) failures...
  64. ncbi NASH-related liver failure: one hit too many?
    Christopher P Day
    Am J Gastroenterol 97:1872-4. 2002
  65. ncbi Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension
    Arun Kundra
    Department of Medicine, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi 110002, India
    Clin Biochem 38:696-9. 2005
    The present study was designed to (a) evaluate and compare plasma ammonia levels (PAL) in patients with acute liver failure (ALF) and chronic liver disease (CLD) with or without hepatic encephalopathy (HE); (b) correlate the severity of ..
  66. ncbi Development of a sensitive prognostic scoring system for the evaluation of severity of acute-on-chronic hepatitis B liver failure: a retrospective cohort study
    Yu Bao Zheng
    Department of Infectious Diseases, The Third Affilliated Hospital, Sun Yat Sen University, Guangzhou City, 510630 PR China
    Clin Invest Med 35:E75-85. 2012
    The purpose of the current study was to establish an objective, simple, and sensitive prognostic scoring system for estimating the severity of acute-on-chronic liver failure in hepatitis B (ACLFB).
  67. doi Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats
    Peter Recknagel
    Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany
    Liver Int 33:283-93. 2013
    Many of the concepts describing molecular mechanisms of sepsis-induced liver failure are derived from endotoxin models...
  68. doi Liver failure after major liver resection: risk assessment by using preoperative Gadoxetic acid-enhanced 3-T MR imaging
    Andreas Wibmer
    From the Departments of Radiology A W, R N, A B S and Surgery A M P, T G, M S, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Radiology 269:777-86. 2013
    ..if gadoxetic acid-enhanced magnetic resonance (MR) imaging with measurement of relative liver enhancement (RLE) on hepatobiliary phase images can allow preoperative assessment of the risk of liver failure after major liver resection.
  69. doi Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure
    Vairappan Balasubramaniyan
    Liver Failure Group, UCL Institute for Liver and Digestive Health, Royal Free Hospital, Pond Street, London NW3 2PF, UK
    J Hepatol 58:1194-200. 2013
    In cirrhosis, superimposed inflammation often culminates in acute-on-chronic liver failure (ACLF) but the mechanism underlying this increased sensitivity is not clear...
  70. pmc p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure
    Jan Heinrichsdorff
    Institute for Genetics, Centre for Molecular Medicine CMMC, and Cologne Excellence Cluster on Cellular Stress Responses in Aging associated Diseases CECAD, University of Cologne, Zülpicher Str 47, D 50674 Cologne, Germany
    EMBO Rep 9:1048-54. 2008
    ..By contrast, LPS injection caused liver failure in mice lacking both p38alpha and IkappaB kinase 2 (IKK2) in hepatocytes...
  71. ncbi Early renal function post-liver transplantation is predictive of progressive chronic kidney disease
    Gustaf Herlenius
    Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Scand J Gastroenterol 43:344-9. 2008
    ....
  72. doi Liver failure in a dog following suspected ingestion of blue-green algae (Microcystis spp.): a case report and review of the toxin
    Lionel Sebbag
    Veterinary Health Center, Kansas State University, Manhattan, KS, USA
    J Am Anim Hosp Assoc 49:342-6. 2013
    ..Ingestion is typically fatal for most patients. This is the first canine to be reported in the literature to survive treatment after known exposure. ..
  73. doi Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration
    Kuno Lehmann
    Swiss Hepato Pancreatico Biliary Center, Department of Surgery, University Hospital Zurich, Zurich, Switzerland
    Gastroenterology 143:1609-1619.e4. 2012
    ..We developed a mouse model to assess the regenerative capacity of a critically small liver remnant...
  74. doi A model to predict 3-month mortality risk of acute-on-chronic hepatitis B liver failure using artificial neural network
    M H Zheng
    Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
    J Viral Hepat 20:248-55. 2013
    ..The aim of this study was to predict 3-month mortality risk of acute-on-chronic hepatitis B liver failure (ACHBLF) on an individual patient level using an artificial neural network (ANN) system...
  75. pmc Epidemiological and clinical features of hepatitis B virus related liver failure in China
    Chen Liu
    Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    World J Gastroenterol 17:3054-9. 2011
    To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China.
  76. doi Lipid peroxidation in acute respiratory distress syndrome and liver failure
    Christoph Lichtenstern
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Giessen and Marburg, Giessen, Germany
    J Surg Res 168:243-52. 2011
    ..to investigate differences in LPO pattern of patients with established acute respiratory distress syndrome (ARDS) and patients with end-stage liver failure undergoing liver transplantation (LTX) as two mayor prototypes of organ failure.
  77. doi A novel ATP7B gene mutation in a liver failure patient with normal ceruloplasmin and low serum alkaline phosphatase
    Li Chen
    Department of Hepatology, Infectious Disease Hospital, Fujian Medical University, Fuzhou, China
    Gene 538:204-6. 2014
    ..We present a liver failure patient, who was misdiagnosed for two years, with normal ceruloplasmin and low serum alkaline phosphatase...
  78. ncbi Trastuzumab plus estrogen suppression as salvage treatment in a case of liver failure due to metastatic breast cancer
    Andrea A Martoni
    Medical Oncology Unit, S Orsola Malpighi Hospital, Bologna, Italy
    Anticancer Res 26:3739-44. 2006
    b>Liver failure associated with metastatic breast cancer is a short-term survival condition in which standard chemotherapy is almost always contraindicated.
  79. doi RAGE blockade and hepatic microcirculation in experimental endotoxaemic liver failure
    A Kuhla
    Institute for Experimental Surgery, University of Rostock, Rostock, Germany
    Br J Surg 100:1229-39. 2013
    ..Therefore, RAGE has potential as a new therapeutic target in sepsis. The aim of this study was to analyse whether RAGE blockade in vivo prevents microcirculatory dysfunction and subsequent tissue injury in endotoxaemic liver failure.
  80. ncbi [A prospective cohort study on the influence of high doses of herbs for clearing heat and resolving stasis on survival rates in patients with hepatitis B-related acute-on-chronic liver failure]
    Xiao Yu Hu
    Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
    Zhong Xi Yi Jie He Xue Bao 10:176-85. 2012
    Hepatitis B-related acute-on-chronic liver failure (ACLF) is a severe clinical syndrome characterized by jaundice, coagulopathy, ascites and hepatic encephalopathy and with a high mortality rate of 65% to 93%...
  81. pmc Cirrhosis and liver failure in nonalcoholic fatty liver disease: Molehill or mountain?
    Michael Charlton
    Hepatology 47:1431-3. 2008
  82. doi Predictive parameters after molecular absorbent recirculating system treatment integrated with model for end stage liver disease model in patients with acute-on-chronic liver failure
    G Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 42:1182-7. 2010
    ..Two homogenous groups were studied: one treated with standard medical therapy (SMT) and the other, with MARS...
  83. doi Altered fasting and postprandial plasma ghrelin levels in patients with liver failure are normalized after liver transplantation
    Maria Teresa Diz-Lois
    Department of Gastroenterology, University Hospital A Coruña Xubias de Arriba 84, Coruna, Spain
    Eur J Endocrinol 163:609-16. 2010
    Anorexia is a problem of paramount importance in patients with advanced liver failure. Ghrelin has important actions on feeding and weight homeostasis. Experimental data exist, which suggest that ghrelin could protect hepatic tissue...
  84. doi Liver failure due to antithyroid drugs: report of a case and literature review
    Sarantis Livadas
    First Department of Internal Medicine, Laiko General Hospital, Medical School, University of Athens, Athens, Greece
    Endocrine 38:24-8. 2010
    ..These agents may cause severe adverse effects and among them liver failure, although rare, is a potential lethal one...
  85. ncbi Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure
    Regina Rodrigo
    Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurochem 102:51-64. 2007
    ..of this pathway and of nitric oxide synthase (NOS) are altered in cerebral cortex in vivo in rats with chronic liver failure due to portacaval shunt (PCS) and whether these alterations are due to hyperammonemia...
  86. doi [Muscle weakness and early stages of liver failure in a 22-year-old man]
    D Scheicht
    Klinik für Rheumatologie, Krankenhaus Porz am Rhein, Akademisches Lehrkrankenhaus der Universitätsklinik Köln, Urbacher Weg 19, 51149, Koln, Deutschland
    Internist (Berl) 54:1016-22. 2013
    ..The course of disease was complicated by liver failure and severe pneumonia requiring ventilatory assistance...
  87. doi Mortality rate of alcoholic liver disease and risk of hospitalization for alcoholic liver cirrhosis, alcoholic hepatitis and alcoholic liver failure in Australia between 1993 and 2005
    W Liang
    National Drug Research Institute, Curtin University, Perth, Western Australia, Australia
    Intern Med J 41:34-41. 2011
    ..The aim of this study was to investigate recent trends in hospital admission rates among alcoholic liver cirrhosis, alcoholic hepatic failure and alcoholic hepatitis in Australia, as well as the mortality of ALD...
  88. ncbi Liver failure and need for liver transplantation in patients with advanced hepatoportal sclerosis
    M Isabel Fiel
    The Lillian and Henry M Stratton Hans Popper Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA
    Am J Surg Pathol 31:607-14. 2007
    ..In conclusion, HPS can cause hepatic synthetic dysfunction that may necessitate LT. Small liver volume, significant portal fibrosis, and phlebosclerosis may contribute to hepatic parenchymal loss and subsequent synthetic compromise...
  89. pmc Amelioration of liver injury by continuously targeted intervention against TNFRp55 in rats with acute-on-chronic liver failure
    Yumin Xu
    Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    PLoS ONE 8:e68757. 2013
    Acute-on-chronic liver failure (ACLF) is an acute deterioration of established liver disease...
  90. ncbi Dissection of the intracellular pathways in hepatocytes suggests a role for Jun kinase and IFN regulatory factor-1 in Con A-induced liver failure
    K Streetz
    Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    J Immunol 167:514-23. 2001
    ..Cytokines are important to determine the outcome of liver failure in this model, and especially TNF-alpha and IFN-gamma directly contribute to hepatocyte damage...
  91. doi Recombinant human growth hormone increases albumin and prolongs survival in patients with chronic liver failure: a pilot open, randomized, and controlled clinical trial
    N Li
    Department of GI and Hepatology, Beijing You an Hospital Affiliated to Capital Medical University, China
    Dig Liver Dis 40:554-9. 2008
    To evaluate the efficacy and safety of recombinant human growth hormone (rhGH) in the treatment of patients with chronic liver failure.
  92. ncbi Nursing care of chronic and acute liver failure
    Sarah Starr
    Princess Alexandra Hospital, Harlow, Essex
    Nurs Stand 16:47-54; quiz 55-6. 2002
    The authors describe the structure and functions of the liver, as well as the main causes and symptoms of chronic and acute liver failure. The nursing assessment and management of patients with liver disease are also examined.
  93. doi Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis
    Qiuning Bu
    Department of Microbiology, School of Basic Medical Sciences, Peking University Infectious Disease Center, Peking University, Beijing 100191, China
    Arch Virol 158:165-72. 2013
    ..of a genotype 4 strain of Hepatitis E virus (HEV) (CHN-NJ-H2011) from a patient (in Nanjing, China) with liver failure has been determined. Phylogenetic analysis showed that CHN-NJ-H2011 belongs to genotype 4, subtype 4h...
  94. ncbi The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthase
    J Nikolic
    Department of Biochemistry, School of Medicine, University of Nis, Nis, Serbia and Montenegro
    Amino Acids 32:127-31. 2007
    ..Results obtained in this study show that mercury chloride-induced toxicity leads to abnormally high levels of ALT and AST that may indicate liver damage with the involvement of polyamine catabolic enzymes and NO...
  95. ncbi Albumin dialysis with molecular adsorbent recirculating system (MARS) for the treatment of hepatic encephalopathy in liver failure
    Ramón A Kobashi-Margáin
    Medica Sur Clinic and Foundation, Biomedical Research Department, Liver Research Unit, Mexico City Mexico
    Ann Hepatol 10:S70-6. 2011
    ..Hepatic encephalopathy is a common neuropsychiatric syndrome that usually accompanies liver failure and impacts greatly on the quality of life...
  96. ncbi The neurology of liver failure
    M Lewis
    Academic Unit of Medicine, St James s University Hospital, Leeds, UK
    QJM 96:623-33. 2003
  97. ncbi Liver transplantation and hepatitis C
    M Willems
    Department of Gastroenterology, University Hospital Dijkzigt, P O Box 2040, 3000 Rotterdam, The Netherlands
    Transpl Int 15:61-72. 2002
    ..of a hepatitis C infection and concomitant disease in the liver graft may cause substantial morbidity, end-stage liver disease and liver failure caused by a chronic hepatitis C infection remain good indications for liver transplantation.
  98. doi Association of cytomegalovirus infection and disease with recurrent hepatitis C after liver transplantation
    Wendelyn Bosch
    Division of Infectious Diseases, Mayo Clinic in Florida, Jacksonville, FL, USA
    Transplantation 93:723-8. 2012
    ..Cytomegalovirus (CMV) has been inconsistently associated with recurrent hepatitis C virus (HCV) after liver transplant (LT)...
  99. ncbi Anti-HBs-positive liver failure due to hepatitis B virus reactivation induced by rituximab
    Toshiki Sera
    Ehime University Graduate School of Medicine, Department of Gastroenterology and Metabology, Shitsukawa, Toon
    Intern Med 45:721-4. 2006
    ..Rituximab appears likely to have induced HBV reactivation in this case. Anti-viral agents should be administered for both HBsAg-positive and anti-HBs-positive patients who are scheduled to receive rituximab...
  100. doi Risk factors for liver failure and mortality after hepatectomy associated with portal vein resection
    Philippe Bachellier
    Centre de Chirurgie Viscerale et de Transplantation, Hôpitaux Universitaires de Strasbourg Université Louis Pasteur, Strasbourg, France
    Ann Surg 253:173-9. 2011
    To report the postoperative outcome of hepatectomy associated with portal vein resection (PVR) and to identify risk factors of clinical value for predicting postoperative liver failure and mortality.
  101. ncbi Serum acute-phase protein level as indicator for liver failure after liver resection
    Pascal Ananian
    Department of Surgery and Liver Transplantation, Hopital de la Conception, Marseille, France
    Hepatogastroenterology 52:857-61. 2005
    We investigated the relationship between postoperative liver failure and serum acute-phase protein level before and after liver resection.

Research Grants74

  1. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..deficient in the tyrosine catabolic enzyme, fumarylacetoacetate hydrolase (Fah -/-) and develop irreversible liver failure if left untreated...
  2. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..in which inflammation kills liver cells, ultimately culminating in liver cirrhosis, portal hypertension, and liver failure. Although NASH is less prevalent (about a quarter of the population with NAFLD have NASH), the number is ..
  3. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..provided by applicant): Although oxidative stress is implicated in both acute acetaminophen-induced liver failure and chronic liver diseases, cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic ..
  4. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..Hepatitis B virus (HBV) can cause chronic infection, resulting in cirrhosis of the liver, liver cancer, liver failure, and death...
  5. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..liver diseases, including viral hepatitis, alcoholic liver disease or hepatic cancer, which frequently lead to liver failure and requires liver transplantation...
  6. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..are chronically infected with HBV leading to nearly one million deaths annually as a result of cirrhosis, liver failure and hepatocellular carcinoma (HCC)...
  7. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..Digibind was effective for PE in a clinical trial. We will develop a novel human monoclonal antibody with higher specificity than Digibind for MBG. This innovative therapeutic humAb will be the first effective treatment of PE. ..
  8. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..Cirrhosis can be further complicated by liver failure, portal hypertension and development of hepatocellular cancer (HCC), making chronic liver disease as the 12th ..
  9. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..diseases, stroke, degenerative neurological diseases, diabetes, arthritis, osteoporosis, kidney and liver failure, spinal cord injury, burns, battlefield trauma, and other devastating conditions...
  10. The Role of Alcohol in HIV Therapy Hepatotoxicity
    Craig J McClain; Fiscal Year: 2012
    ..Here, we will study hepatotoxicity due to alcohol/HAART interactions to further define disease mechanisms and create therapeutic interventions. ..
  11. Modifiers of hepcidin expression as new therapies for iron overload
    PAULA GOODMAN FRAENKEL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Iron overload syndromes remain important causes of heart and liver failure in patients with thalassemia or hereditary hemochromatosis, which are common genetic diseases worldwide...
  12. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
    ..is being developed as a minimally invasive alternative to liver transplantation for patients with liver failure or inherite metabolic disorders...
  13. UT GASTROENTEROLOGY / HEPATOLOGY RESEARCH TRAINING PROGRAM
    Ezra Burstein; Fiscal Year: 2013
    ..liver steatosis, lipid metabolism and gallstone disease;immune responses in the liver and acute liver failure;hepatic fibrosis and portal hypertension;and, viral hepatitis and anti-viral immunity...
  14. Excessive Copper Levels Disrupt Hepatic Nuclear Receptor Function
    Clavia Ruth Wooton-Kee; Fiscal Year: 2011
    ..ATPase, ATP7b, and is associated with a variety of symptoms including steatosis, cholestasis, cirrhosis, and liver failure, as well as neurological dysfunction...
  15. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis, liver failure and death...
  16. Sterile Hepatic Inflammation
    Wajahat Zafar Mehal; Fiscal Year: 2012
    ..In addition this also results in increased mortality due to cirrhosis, hepatocellular cancer as well as liver failure. Currently there are no effective treatments these liver diseases...
  17. Novel Small Molecule Therapeutics to Treat Obesity
    SUSAN MEDGHALCHI; Fiscal Year: 2010
    ..and Type II diabetes, and non- alcoholic steatohepatitis (NASH), which may progress to cirrhosis and liver failure. GPAT (glycerol-3- phosphate acyltransferase) is the initial committed step in acylglycerol synthesis and has ..
  18. Colorado Center for Childhood Liver Disease Research and Education
    Ronald J Sokol; Fiscal Year: 2013
    ..fat-soluble vitamin malabsorption;and progressive hepatic fibrosis, portal hypertension and eventually chronic liver failure. Investigation of these disorders promises to advance scientific knowledge about liver development, ..
  19. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Acute liver failure (ALF) constitutes a challenge to clinicians and scientists alike...
  20. Dichotomous Roles of Thrombin in Acetaminophen Hepatotoxicity
    ROBERT ANDREW ROTH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Overdose with acetaminophen (APAP) is the most common cause of acute liver failure in humans...
  21. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
    ..provided by applicant): Brain edema and associated intracranial hypertension are major complications of acute liver failure (ALF), which has a high mortality and for which therapeutic options are largely limited to an emergency liver ..
  22. Developing Novel Serological Biomarkers for Autoimmune Liver Diseases
    Xuhang Li; Fiscal Year: 2013
    ..AILDs result in marked suffering and serious consequences of AILDs lead to liver failure and hepatobiliary malignancy...
  23. Mechanisms of ER stress - induced fatty liver
    D Thomas Rutkowski; Fiscal Year: 2013
    ..steatohepatitis that compromises liver function, leading to inflammation, fibrosis, cirrhosis, and ultimately liver failure. While FLD most likely reflects an imbalance between lipid synthesis, storage, oxidation, and/or secretion, ..
  24. Nrf2 as a Master Regulator in Liver Disease Prevention and Therapy
    Curtis D Klaassen; Fiscal Year: 2012
    ..Liver disease is a common ailment, however in contrast to most other diseases, there are very few drugs for liver failure. We hypothesize that Nrf2, an essential transcription factor, is a drug target that can be used to prevent and ..
  25. L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicity
    W Ray Kim; Fiscal Year: 2011
    ..Liver transplantation (LTx) is now well-established as a means of restoring health in patients with liver failure, the 10th leading cause of death in the US...
  26. Oxygen/Nitrogen Stress in Acetaminophen Hepatotoxicity
    Jack A Hinson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acetaminophen (APAP) poisoning is the most common cause of acute liver failure in the U.S...
  27. Keratin Biology and Disease Aspects in Simple Epithelia
    Bishr Omary; Fiscal Year: 2013
    ..iii) Examine the utility of assessing keratin apoptotic fragments in patients with acute liver failure. The hypothesis for Aim#3 is that apoptosis during acute liver injury results in leakage of the highly ..
  28. Suppression of the Interferon Response by the Hepatitis C Virus
    FRANCIS VINCENT CHISARI; Fiscal Year: 2010
    ..by HCV in the USA and 170 million people are chronically infected worldwide, many of whom will die from liver failure and hepatocelluar carcinoma...
  29. ROLE OF WNT SIGNALING IN CHRONIC ALCOHOLIC LIVER DISEASE
    Miran Kim; Fiscal Year: 2013
    ..stages of steatohepatitis, fibrosis, cirrhosis, and finally end-stage liver disease, which culminates in liver failure. ALD is common, and accounts for 28% of all deaths from liver disease in the USA...
  30. Recombinant Polymers for Transarterial Chemoembolization of Liver Cancer
    AZADEH POURSAID; Fiscal Year: 2013
    ..have little efficacy and 85% of patients diagnosed with HCC at any stage die within 5 years either from liver failure or metastatic disease...
  31. Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virus
    Charles M Rice; Fiscal Year: 2013
    ..Persistent HCV infection can have severe health consequences, including hepatitis, cirrhosis, liver failure, and hepatocellular carcinoma...
  32. Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRI
    Scott B Reeder; Fiscal Year: 2013
    ..These patients develop cirrhosis and may succumb to liver failure and/or hepatocellular carcinoma, necessitating liver transplant...
  33. Role for tissue-type plasminogen activator in suppression of hepatic fibrosis
    Liang I Kang; Fiscal Year: 2013
    ..of a variety of chronic inflammatory liver diseases, and if untreated, will progress into cirrhosis and liver failure. With the dramatic increased prevalence of non-alcoholic fatty liver disease and chronic hepatitis C worldwide,..
  34. Synergistic actions by multiple Toll-like receptors in alcoholic liver disease
    Ekihiro Seki; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic alcohol abuse is the major cause of cirrhosis and liver failure in adult patients in the United States...
  35. Dipstick Assay for Detection of Acetaminophen Protein Adducts
    Laura P James; Fiscal Year: 2010
    ..APAP toxicity is the most common cause of acute liver failure (ALF) in the United States and Great Britain today...
  36. Novel prognostic microRNA biomarkers for primary sclerosing cholangitis
    Kris Kowdley; Fiscal Year: 2013
    ..of bile ducts, PSC often progresses to advanced live disease such as cirrhosis, hepatobiliary cancer and liver failure. Without an effective therapeutic option, liver transplantation is currently considered the only curative ..
  37. FAH-Deficient Pigs
    Scott L Nyberg; Fiscal Year: 2011
    ..animal models, which in turn has limited development of new therapies for metabolic liver disorders, acute liver failure, chronic (cirrhotic) liver disease, an hepatocellular carcinoma...
  38. Liver Inflammation and Injury: Molecular Mechanisms
    Mario Chojkier; Fiscal Year: 2013
    ..In acute and chronic liver diseases, through inflammation and injury induce damage to the liver, resulting in liver failure. Excessive liver damage accounts for the significant complications and mortality among the VA population with ..
  39. Role of HCV Sequence Variation in Pathology
    John E Tavis; Fiscal Year: 2010
    Chronic Hepatitis C virus (HCV) infection causes hepatitis, cirrhosis, liver failure, and hepatocellular carcinoma. The factors governing the rate of disease progression along this spectrum of pathology are not known...
  40. Analysis of Fatty Liver in the Framingham Heart Study Cohort
    Elizabeth K Speliotes; Fiscal Year: 2012
    ..increase in obesity, many people have fat deposited in their liver that can lead to liver cirrhosis and liver failure;nevertheless, little is known about the genetic epidemiology or metabolic consequences of fatty liver. Dr...
  41. Telehealth-Enabled Ultrasound-Bioimpedance Viscoelastographic Edema Monitoring
    William F Weitzel; Fiscal Year: 2013
    ..status for a number of disease states, including chronic kidney disease (CKD), congestive heart failure (CHF), liver failure, and lymphedema...
  42. Mechanisms of Liver Failure
    Chandrashekhar R Gandhi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute liver failure (ALF), a devastating condition that affects patients with and without prior liver disease, has a mortality rate of 80% (>20,000 deaths/year in the USA)...
  43. Drs2p Function in Clathrin-coated Vesicle Budding
    Todd R Graham; Fiscal Year: 2013
    ..in the bile canalicular membrane leads to damage of this membrane by secreted bile, ultimately leading to liver failure. P4-ATPase deficiency in mice is linked to diet induced obesity and type 2 diabetes (Atp10a and Atp10d) as ..
  44. A Novel Therapeutic Approach for Liver Injury
    Xiaoling Qiang; Fiscal Year: 2010
    ..provided by applicant): Liver injury induced by hepatic ischemia and reperfusion (I/R) is a major cause of liver failure after severe trauma, thermal injury, hemorrhagic and septic shock, liver resection, or liver transplantation...
  45. LIPIN 1 IN THE REGULATION OF HEPATIC LIPID METABOLISM
    Brian N Finck; Fiscal Year: 2013
    ..Although steatohepatitis can progress to cirrhosis and liver failure, the most common co-morbidity of NAFLD is hepatic insulin resistance and systemic abnormalities in circulating ..
  46. Ah Receptor Anatomy: Implications for Dioxin Toxicity
    CORNELIS JOHAN ELFERINK; Fiscal Year: 2011
    ..Dysregulation in the repair process can lead o liver failure or liver cancer...
  47. Designing a Microenvironment Niche for Liver-Specific Differentiation of hESCs
    Alexander Revzin; Fiscal Year: 2013
    ..However, the number of donor livers is severely inadequate and a large fraction of patients with liver failure do not receive a donor organ...
  48. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2013
    ..Demonstrating A20's beneficial effects in our experimental models should set the basis for translating A20- based therapies into clinical practice. ..
  49. Cellular Mechanisms of Hepatotoxicity.
    Neil Kaplowitz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acetaminophen (APAP) toxicity is the leading cause of acute liver failure. The mouse model of APAP hepatotoxicity is highly reproducible and widely utilized to elucidate the mechanisms of liver ..
  50. Liver innate immunity in drug-induced liver disease.
    Zhang Xu Liu; Fiscal Year: 2012
    ..provided by applicant): Acetaminophen (APAP) hepatotoxicity is currently the most common cause of acute liver failure in the United States...
  51. Autophagy in liver injury
    Jae Sung Kim; Fiscal Year: 2013
    ..into lethal I/R injury to liver, and will establish novel therapeutic approaches for improving I/R-mediated liver failure. PUBLIC HEALTH RELEVANCE: Impairment of blood flow causes a tissue ischemia and recovery of blood flow causes ..
  52. PDGFR and KDR Inhibitors for Liver Fibrosis
    Bert Oehlen; Fiscal Year: 2010
    ..B or C, excessive alcohol use, iron overload or extrahepatic obstructions and can progress to liver cirrhosis, liver failure and death...
  53. Integrating plasma IGF-1 into novel classification of hepatocellular carcinoma
    Ahmed Kaseb; Fiscal Year: 2013
    ..This selection criterion facilitates assessment of the effect of treatment without the confounding issues of liver failure and death as a result of underlying cirrhosis...
  54. Circulating miRNA as a biomarker for biliary atresia
    Joshua R Friedman; Fiscal Year: 2013
    ..If untreated, the disease uniformly progresses to biliary cirrhosis, liver failure, and death within 2 years...
  55. LPS binding to TLR4 regulates hepatic stellate cell activation and fibrosis
    Ekihiro Seki; Fiscal Year: 2013
    ..viral hepatitis, autoimmune diseases, and non- alcoholic steatohepatitis (NASH), can progress to cirrhosis, liver failure, portal hypertension, and hepatocellular carcinoma...
  56. Hepatitis C Clinical Trial-Clinical Center
    Jules L Dienstag; Fiscal Year: 2009
    ..with chronic hepatitis C who do not respond to antiviral treatment are at risk of progression to cirrhosis, liver failure, hepatocellular carcinoma (HCC) and death...
  57. Biomarker for liver ischemia/reperfusion-induced injury
    MONIKA OLI; Fiscal Year: 2006
    ..Liver injury induced by hepatic ischemia followed by reperfusion is a major pathogenic cause of liver failure during multiple trauma, thermal injury, hemorrhagic and septic shock, and liver transplantation, which ..
  58. Open-Source Informatics Used to Improve Outcomes in Pediatric Liver Transplants
    STEVEN PETER BUCUVALAS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Twenty-five years ago, a two-year old with liver failure had no medical or surgical options for survival...
  59. DEVELOPMENT OF A NOVEL BIOARTIFICIAL LIVER
    Jacek Rozga; Fiscal Year: 2002
    ARBIOS developed a novel hybrid bioartificial live r(HyBAL) to treat patients with liver failure of various etiologies...
  60. 2010 Molecular Biology of Hepatitis B Viruses Meeting
    Adam Zlotnick; Fiscal Year: 2010
    ..Chronic HBV contributes to the deaths of some 600,000 people annually mainly by liver failure, cirrhosis, and hepatocellular carcinoma...
  61. Serologic test for neonatal hemochromatosis in infants with acute liver failure
    PETER FRANK WHITINGTON; Fiscal Year: 2010
    ..This application specifically seeks to develop an approach that will improve the diagnosis of acute liver failure in infants, result in significantly improved outcome with medical therapy, and reduce the utilization of liver ..
  62. Novel therapeutic for Alcoholic Liver Disease
    Bert Oehlen; Fiscal Year: 2009
    ..Liver Disease (ALD) is a progressive liver disease that in advanced stages can result in cirrhosis and liver failure. ALD can be divided in various stages of development: (1) mild alcoholic liver injury, (2) steatosis, (3) ..
  63. Diagnosing and monitoring NAFLD using unbound FFA profiles
    Alan Kleinfeld; Fiscal Year: 2009
    ..NAFLD is a progressive disease in which simple steatosis can lead to steatohepatitis, cirrhosis, liver failure and hepatocellular carcinoma...
  64. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..b>Liver failure is an important clinical problem that occurs after a variety of toxic, traumatic, and infectious insults...
  65. HYBRID ARTIFICIAL LIVER USING IMMOBILIZED HEPATOCYTES
    Ronald Tompkins; Fiscal Year: 1991
    ..developed in this work will provide a rational basis for design of treatment modalities for acute and chronic liver failure. The viability and function of the hepatocytes will be examined in the short and long term...
  66. Engineered 3-D Human Liver Tissue for Hepatitis Studies
    BRIAN NAUGHTON; Fiscal Year: 2004
    ..HCV infection of the liver progresses to cirrhosis followed by hepatocellular carcinoma and ultimately liver failure, and is the leading reason for liver transplantation...
  67. STUDIES OF THE NATURAL HISTORY OF HEPATITIS C IN LIVER
    Robert Carithers; Fiscal Year: 2002
    ..As a consequence, liver failure from chronic hepatitis C has become the leading indication for liver transplantation both in the United States ..