fatty liver

Summary

Summary: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.

Top Publications

  1. ncbi Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
  2. ncbi Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    Giulio Marchesini
    Unit of Metabolic Diseases and Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Hepatology 37:917-23. 2003
  3. ncbi Nonalcoholic fatty liver disease: from steatosis to cirrhosis
    Geoffrey C Farrell
    The Storr Liver Unit, Westmead s Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Hepatology 43:S99-S112. 2006
  4. pmc Human fatty liver disease: old questions and new insights
    Jonathan C Cohen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Science 332:1519-23. 2011
  5. pmc Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    Catherine Postic
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 118:829-38. 2008
  6. ncbi Nonalcoholic fatty liver disease
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    N Engl J Med 346:1221-31. 2002
  7. pmc Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    Jorge Henao-Mejia
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 482:179-85. 2012
  8. pmc Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA
    Nat Genet 40:1461-5. 2008
  9. ncbi Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Diabetes 50:1844-50. 2001
  10. doi Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    G Vernon
    Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA 22042, USA
    Aliment Pharmacol Ther 34:274-85. 2011

Detail Information

Publications421 found, 100 shown here

  1. ncbi Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    David E Kleiner
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 41:1313-21. 2005
    Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the absence of a history of significant alcohol use or other known liver disease. Nonalcoholic steatohepatitis (NASH) is the progressive form of NAFLD...
  2. ncbi Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    Giulio Marchesini
    Unit of Metabolic Diseases and Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Hepatology 37:917-23. 2003
    Nonalcoholic fatty liver disease (NAFLD) has been associated with the insulin-resistance syndrome, at present defined as the metabolic syndrome, whose limits were recently set...
  3. ncbi Nonalcoholic fatty liver disease: from steatosis to cirrhosis
    Geoffrey C Farrell
    The Storr Liver Unit, Westmead s Millennium Institute, University of Sydney at Westmead Hospital, Westmead, NSW, Australia
    Hepatology 43:S99-S112. 2006
    ..Nonalcoholic steatohepatitis (NASH), the lynchpin between steatosis and cirrhosis in the spectrum of nonalcoholic fatty liver disorders (NAFLD), was barely recognized in 1981...
  4. pmc Human fatty liver disease: old questions and new insights
    Jonathan C Cohen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Science 332:1519-23. 2011
    Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries...
  5. pmc Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    Catherine Postic
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 118:829-38. 2008
    Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes...
  6. ncbi Nonalcoholic fatty liver disease
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    N Engl J Med 346:1221-31. 2002
  7. pmc Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    Jorge Henao-Mejia
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 482:179-85. 2012
    Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease in the Western world...
  8. pmc Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    Stefano Romeo
    Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA
    Nat Genet 40:1461-5. 2008
    Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown etiology that varies in prevalence among ancestry groups...
  9. ncbi Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    G Marchesini
    Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Diabetes 50:1844-50. 2001
    ..m(-2). min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2)...
  10. doi Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    G Vernon
    Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA 22042, USA
    Aliment Pharmacol Ther 34:274-85. 2011
    Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease, and its worldwide prevalence continues to increase with the growing obesity epidemic...
  11. ncbi Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    Hepatology 40:1387-95. 2004
    Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), its pathogenesis and clinical significance remain poorly defined...
  12. pmc AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    Yu Li
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02481, USA
    Cell Metab 13:376-88. 2011
    ..AMPK-dependent phosphorylation of SREBP may offer therapeutic strategies to combat insulin resistance, dyslipidemia, and atherosclerosis...
  13. pmc Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    Quentin M Anstee
    Department of Medicine A, St Mary s Campus, Imperial College, London, UK
    Int J Exp Pathol 87:1-16. 2006
    Non-alcoholic fatty liver disease (NAFLD) represents a histological spectrum of liver disease associated with obesity, diabetes and insulin resistance that extends from isolated steatosis to steatohepatitis and cirrhosis...
  14. doi Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Innsbruck, Austria
    Hepatology 52:1836-46. 2010
    Whereas in most cases a fatty liver remains free of inflammation, 10%-20% of patients who have fatty liver develop inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]). Inflammation may precede steatosis in certain instances...
  15. pmc Lipid-induced insulin resistance: unravelling the mechanism
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Lancet 375:2267-77. 2010
    ..This unifying hypothesis accounts for the mechanism of insulin resistance in obesity, type 2 diabetes, lipodystrophy, and ageing; and the insulin-sensitising effects of thiazolidinediones...
  16. pmc Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    Yoshihisa Takahashi
    Department of Pathology, Teikyo University School of Medicine, Tokyo 173 8605, Japan
    World J Gastroenterol 18:2300-8. 2012
    Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in the liver of a patient without a history of alcohol abuse...
  17. doi Nonalcoholic fatty liver disease: a review and update
    Jeffrey R Lewis
    Department of Medicine, Center for Liver Diseases, University of Chicago, Chicago, IL 60637, USA
    Dig Dis Sci 55:560-78. 2010
    The spectrum of nonalcoholic fatty liver disease (NAFLD) ranges from asymptomatic steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis...
  18. doi Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
    Brad Q Starley
    Department of Medicine, Division of Gastroenterology and Hepatology, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
    Hepatology 51:1820-32. 2010
    ..The most common form of chronic liver disease in developed countries is nonalcoholic fatty liver disease (NAFLD), which encompasses a broad spectrum of histopathology...
  19. pmc Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    J Clin Invest 103:1489-98. 1999
    ..By modulating gene expression, PPARalpha stimulates hepatic fatty acid oxidation to supply substrates that can be metabolized by other tissues...
  20. ncbi Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    A J Sanyal
    Division of Gastroenterology Hepatology, Department of Internal Medicine, Virginia Commonwealth University Medical College of Virginia, Richmond, Virginia 23298 0711, USA
    Gastroenterology 120:1183-92. 2001
    ....
  21. pmc Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
    J Clin Invest 115:1343-51. 2005
    Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess liver triacylglycerol (TAG), inflammation, and liver damage...
  22. ncbi Prevalence of fatty liver in children and adolescents
    Jeffrey B Schwimmer
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, 200 West Arbor Dr, San Diego, CA 92103 8450, USA
    Pediatrics 118:1388-93. 2006
    b>Fatty liver disease is diagnosed increasingly in children, but the prevalence remains unknown. We sought to determine the prevalence of pediatric fatty liver as diagnosed by histology in a population-based sample.
  23. pmc Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hepatology 51:679-89. 2010
    Obesity is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD)...
  24. doi Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
    Christopher D Williams
    Gastroenterology and Hepatology Service, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas 78234, USA
    Gastroenterology 140:124-31. 2011
    Prevalence of nonalcoholic fatty liver disease (NAFLD) has not been well established. The purpose of this study was to prospectively define the prevalence of both NAFLD and nonalcoholic steatohepatitis (NASH).
  25. doi Identification and characterization of metabolically benign obesity in humans
    Norbert Stefan
    Department of Internal Medicine IV, University of Tubingen, D 72076 Tubingen, Germany
    Arch Intern Med 168:1609-16. 2008
    ..Conversely, even in obesity, a metabolically benign fat distribution phenotype may exist...
  26. pmc Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    Joel E Lavine
    Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University, New York, New York, USA
    JAMA 305:1659-68. 2011
    Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in US children and adolescents and can present with advanced fibrosis or nonalcoholic steatohepatitis (NASH). No treatment has been established.
  27. doi Causes and metabolic consequences of Fatty liver
    Norbert Stefan
    Department of Internal Medicine, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Endocr Rev 29:939-60. 2008
    ..and particularly visceral adiposity are established risk factors for these diseases, in the recent years fatty liver emerged as an additional and independent factor...
  28. doi Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University, St Louis, MO 63110, USA
    Hepatology 52:774-88. 2010
    ....
  29. pmc Molecular mediators of hepatic steatosis and liver injury
    Jeffrey D Browning
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390 9046, USA
    J Clin Invest 114:147-52. 2004
    ..Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis...
  30. doi Epidemiology of non-alcoholic fatty liver disease in China
    Jian Gao Fan
    Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
    J Hepatol 50:204-10. 2009
    b>Fatty liver (steatosis) is highly prevalent in China and is more often linked to obesity than to alcoholism. Among more affluent regions of China, the community prevalence of non-alcoholic fatty liver disease (NAFLD) is approximately 15%...
  31. pmc Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Metab 9:327-38. 2009
    Hepatic metabolic derangements are key components in the development of fatty liver, insulin resistance, and atherosclerosis...
  32. ncbi A lipidomic analysis of nonalcoholic fatty liver disease
    Puneet Puri
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Hepatology 46:1081-90. 2007
    The spectrum of nonalcoholic fatty liver disease (NAFLD) includes a nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). The specific types and amounts of lipids that accumulate in NAFLD are not fully defined...
  33. pmc Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management
    Raj Vuppalanchi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 49:306-17. 2009
    Nonalcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease in the western world. It is now recognized that these patients have myriad of important co-morbidities (e.g...
  34. ncbi Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
    Elisabetta Bugianesi
    Department of Gastroenterology, Ospedale S Giovanni Battista, University of Turin, Turin, Italy
    Gastroenterology 123:134-40. 2002
    ..Nonalcoholic steatohepatitis (NASH) may progress to cirrhosis; whether NASH plays also a role in the development of hepatocellular carcinoma (HCC) is unknown...
  35. doi Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    Anabela P Rolo
    Center for Neuroscience and Cell Biology, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 52:59-69. 2012
    ..rising prevalence of obesity and insulin resistance is associated with a parallel increase in nonalcoholic fatty liver disease (NAFLD)...
  36. ncbi Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference
    Brent A Neuschwander-Tetri
    Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, MO 63110, USA
    Hepatology 37:1202-19. 2003
    b>Fatty liver disease that develops in the absence of alcohol abuse is recognized increasingly as a major health burden...
  37. doi Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    Silvia Sookoian
    Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
    Hepatology 53:1883-94. 2011
    ..of the I148M (rs738409 C/G) patatin-like phospholipase domain containing 3 (PNPLA3) variant on nonalcoholic fatty liver (NAFLD) and disease severity across different populations...
  38. pmc Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    Nitika Arora Gupta
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hepatology 51:1584-92. 2010
    ..Small interfering RNA against GLP-1R abolished the effects on PDK-1 and PKC-zeta. Treatment with exendin-4 quantitatively reduced triglyceride stores compared with control-treated cells...
  39. pmc Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    Arun J Sanyal
    Virginia Commonwealth University, Richmond, USA
    N Engl J Med 362:1675-85. 2010
    ..Nonalcoholic steatohepatitis is a common liver disease that can progress to cirrhosis. Currently, there is no established treatment for this disease...
  40. pmc The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals
    Young Ah Moon
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Cell Metab 15:240-6. 2012
    ..Inhibition of SREBP activation has therapeutic potential for treatment of hypertriglyceridemia and fatty liver disease.
  41. doi Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling
    Kento Imajo
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Yokohama, Japan
    Cell Metab 16:44-54. 2012
    ..Our results indicate that obesity-induced leptin plays a crucial role in NASH progression via enhanced responsivity to endotoxin, and we propose a mechanism of bacteria-mediated progression of NASH...
  42. doi Inflammation and fibrogenesis in steatohepatitis
    Hideki Fujii
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 47:215-25. 2012
    Nonalcoholic fatty liver disease consists of a range of disorders characterized by excess accumulation of triglyceride within the liver...
  43. pmc Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease
    Hae Ki Min
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Cell Metab 15:665-74. 2012
    Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality...
  44. ncbi Metabolic syndrome and risk factors for non-alcoholic fatty liver disease
    Mônica Rodrigues de Araújo Souza
    Universidade Federal da Paraiba, PB, Brasil
    Arq Gastroenterol 49:89-96. 2012
    Non-alcoholic fatty liver disease (NAFLD), hepatic manifestation of metabolic syndrome, has been considered the most common liver disease nowadays, which is also the most frequent cause of elevated transaminases and cryptogenic cirrhosis...
  45. ncbi Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 279:32345-53. 2004
    ..high fat feeding in rats results specifically in hepatic fat accumulation and provides a model of non-alcoholic fatty liver disease in which to study the mechanism of hepatic insulin resistance...
  46. ncbi The utility of radiological imaging in nonalcoholic fatty liver disease
    Sherif Saadeh
    Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Gastroenterology 123:745-50. 2002
    ..This prospective study evaluates the role of radiological modalities in establishing the diagnosis of nonalcoholic steatohepatitis (NASH)...
  47. pmc Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
    Naoki Kumashiro
    Howard Hughes Medical Institute and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 108:16381-5. 2011
    Insulin resistance is associated with nonalcoholic fatty liver disease (NAFLD) and is a major factor in the pathogenesis of type 2 diabetes...
  48. pmc The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study
    Neeraj Bhala
    Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    Hepatology 54:1208-16. 2011
    Information on the long-term prognosis of nonalcoholic fatty liver disease (NAFLD) is limited...
  49. doi Non-alcoholic fatty liver disease: the mist gradually clears
    Nimantha Mark Wilfred de Alwis
    Liver Group, Institute of Cellular Medicine, Newcastle University, United Kingdom
    J Hepatol 48:S104-12. 2008
    Non-alcoholic fatty liver disease (NAFLD) is now the commonest liver disorder in the developed world affecting up to a third of individuals...
  50. pmc A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    Shaoqing He
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:6706-15. 2010
    ..These data are consistent with PNPLA3-I148M promoting triglyceride accumulation by limiting triglyceride hydrolysis...
  51. ncbi Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study
    M Capanni
    Nutrition Center and Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Aliment Pharmacol Ther 23:1143-51. 2006
    ..a role of n-3 long-chain polyunsaturated fatty acids (n-3 PUFA) as peroxisome proliferator-activated receptor-alpha ligands in improving non-alcoholic fatty liver disease (NAFLD) in rodents. However, data in humans are still lacking.
  52. doi From the metabolic syndrome to NAFLD or vice versa?
    Ester Vanni
    Division of Gastro Hepatology, San Giovanni Battista Hospital, University of Turin, c so Bramante 88, 10126 Turin, Italy
    Dig Liver Dis 42:320-30. 2010
    ..Nonalcoholic fatty liver disease (NAFLD) comprises a disease spectrum which includes variable degrees of simple steatosis (nonalcoholic ..
  53. doi Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications
    Kenneth Cusi
    Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, Florida 32610 0226, USA
    Gastroenterology 142:711-725.e6. 2012
    As obesity reaches epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is becoming a frequent cause of patient referral to gastroenterologists...
  54. pmc Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings
    Elizabeth M Brunt
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Hepatology 53:810-20. 2011
    ..A separate system of scoring the features of nonalcoholic fatty liver disease (NAFLD) called the NAFLD Activity Score (NAS) was developed as a tool to measure changes in NAFLD ..
  55. ncbi Fatty liver: a novel component of the metabolic syndrome
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Finland, FIN 00029 HUCH, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 28:27-38. 2008
    ..is not attributable to alcohol or other known causes of liver disease, a condition defined as nonalcoholic fatty liver disease (NAFLD) by gastroenterologists. The fatty liver is insulin resistant...
  56. ncbi Non-alcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines
    Shivakumar Chitturi
    Gastroenterology and Hepatology Unit, The Canberra Hospital, Canberra, Australian Capital Territory, Garran, Australia
    J Gastroenterol Hepatol 22:778-87. 2007
    Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western industrialized countries, affecting 20-40% of the general population...
  57. ncbi Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation
    Janardan K Reddy
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611 3008, USA
    Am J Physiol Gastrointest Liver Physiol 290:G852-8. 2006
    b>Fatty liver disease (FLD), whether it is alcoholic FLD (AFLD) or nonalcoholic FLD (NAFLD), encompasses a morphological spectrum consisting of hepatic steatosis (fatty liver) and steatohepatitis...
  58. pmc Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice
    Chih Wen Lin
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
    J Hepatol 58:993-9. 2013
    Pharmacological approaches can potentially improve fatty liver condition in alcoholic and non-alcoholic fatty liver diseases...
  59. pmc Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease
    Steven D Kunkel
    Department of Internal Medicine, and Fraternal Order of Eagles Diabetes Research Center, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e39332. 2012
    Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose intolerance and fatty liver disease...
  60. pmc Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease
    Alexandra K Leamy
    Department of Chemical and Biomolecular Engineering, Vanderbilt University, VU Station B 351604, Nashville, TN 37235, USA
    Prog Lipid Res 52:165-74. 2013
    ..closely linked to significant increases in a multitude of accompanying health problems including non-alcoholic fatty liver disease (NAFLD)...
  61. doi The epidemiology of nonalcoholic fatty liver disease: a global perspective
    Mariana Lazo
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Semin Liver Dis 28:339-50. 2008
    Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver disease in the United States and worldwide...
  62. doi Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
    Tiphaine Le Roy
    INRA, UMR1319 MICALIS, Jouy en Josas, France
    Gut 62:1787-94. 2013
    Non-alcoholic fatty liver disease (NAFLD) is prevalent among obese people and is considered the hepatic manifestation of metabolic syndrome. However, not all obese individuals develop NAFLD...
  63. doi Intestinal microbiota in patients with nonalcoholic fatty liver disease
    Marialena Mouzaki
    Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
    Hepatology 58:120-7. 2013
    ..microbiota (IM) is involved in the pathogenesis of obesity, the IM composition of patients with nonalcoholic fatty liver disease (NAFLD) has not been well characterized...
  64. pmc Endoplasmic reticulum stress in liver disease
    Harmeet Malhi
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    J Hepatol 54:795-809. 2011
    ..The UPR is activated in several liver diseases; including obesity associated fatty liver disease, viral hepatitis, and alcohol-induced liver injury, all of which are associated with steatosis, raising ..
  65. doi Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee
    Pietro Vajro
    Department of Pediatrics, Medical School, University of Salerno, Salerno, Italy
    J Pediatr Gastroenterol Nutr 54:700-13. 2012
    Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children and adolescents in the United States, and most probably also in the rest of the industrialized world...
  66. doi Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
    Romina Lomonaco
    Diabetes, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Hepatology 55:1389-97. 2012
    The role of adipose tissue insulin resistance in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains unclear. To evaluate this, we measured in 207 patients with NAFLD (age = 51 ± 1, body mass index = 34.1 ± 0...
  67. doi The role of the gut microbiota in nonalcoholic fatty liver disease
    Ahmed Abu-Shanab
    Alimentary Pharmabiotic Centre, Biosciences Institute, Floor 5, University College Cork, Cork, Ireland
    Nat Rev Gastroenterol Hepatol 7:691-701. 2010
    ..Several lines of evidence suggest a role for the gut microbiota in both the etiology of nonalcoholic fatty liver disease (NAFLD) and progression to its more advanced state, nonalcoholic steatohepatitis (NASH)...
  68. pmc Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance
    Sung Hee Choi
    Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Korea
    Trends Endocrinol Metab 22:353-63. 2011
    ..Understanding the complex inter-relationships between IR and these abnormalities of liver lipid homeostasis will provide insights relevant to new therapies for these increasing clinical problems...
  69. doi Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease
    Anna Alisi
    Unit of Metabolic and Autoimmune Liver Diseases, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Lab Invest 91:283-93. 2011
    Nonalcoholic fatty liver disease (NAFLD) is an emerging disease with a broad spectrum of liver conditions. The complex molecular pathogenesis of NAFLD is still unclear...
  70. pmc Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    Tsuguhito Ota
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 118:316-32. 2008
    ..These results suggest that excessive ER stress in response to increased hepatic lipids may decrease the ability of the liver to secrete triglycerides by limiting apoB secretion, potentially worsening steatosis...
  71. ncbi Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    Julia Araya
    Departamento de Nutricion, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70058, Santiago 7, Santiago, Chile
    Clin Sci (Lond) 106:635-43. 2004
    Hepatic steatosis is a major feature associated with NAFLD (non-alcoholic fatty liver disease)...
  72. doi Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    Shin Yoshimoto
    Division of Cancer Biology, Cancer Institute, Japanese Foundation for Cancer Research, Koto ku, Tokyo 135 8550, Japan
    Nature 499:97-101. 2013
    ..These findings provide valuable new insights into the development of obesity-associated cancer and open up new possibilities for its control. ..
  73. ncbi Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study
    Giorgio Bedogni
    Centro Studi Fegato, Area Science Park, Basovizza, and Department of BBCM, University of Trieste, Italy
    Hepatology 42:44-52. 2005
    The prevalence of and the risk factors for fatty liver have not undergone a formal evaluation in a representative sample of the general population...
  74. pmc Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    Douglas Osei-Hyiaman
    National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:1298-305. 2005
    ..We conclude that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation...
  75. ncbi Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults
    Hae Jin Kim
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Arch Intern Med 164:2169-75. 2004
    Obesity and type 2 diabetes are well-known risk factors for the development of nonalcoholic fatty liver disease (NAFLD). However, NAFLD is not rare in nonobese, nondiabetic adults...
  76. ncbi The natural history of nonalcoholic fatty liver disease: a population-based cohort study
    Leon A Adams
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:113-21. 2005
    The natural history of nonalcoholic fatty liver disease (NAFLD) in the community remains unknown. We sought to determine survival and liver-related morbidity among community-based NAFLD patients.
  77. pmc Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model
    Jia Xiao
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, L1 41, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong, SAR
    Eur J Nutr 52:179-91. 2013
    To investigate the hepato-protective properties and underlying mechanisms of SAMC in a non-alcoholic fatty liver disease (NAFLD) rat model.
  78. ncbi Long-term follow-up of patients with NAFLD and elevated liver enzymes
    Mattias Ekstedt
    Division of Gastroenterology and Hepatology, Department of Molecular and Clinical Medicine, University Hospital, Linkoping, Sweden
    Hepatology 44:865-73. 2006
    Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated liver enzymes in patients of developed countries. We determined the long-term clinical and histological courses of such patients...
  79. doi Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction
    Paulina Pettinelli
    Department of Food Science, Nutrition, and Dietetics, Faculty of Pharmacy, University of Concepcion, Casilla 237, Concepcion, Chile
    J Clin Endocrinol Metab 96:1424-30. 2011
    Triglyceride accumulation in the liver is an early feature in the development of nonalcoholic fatty liver disease (NAFLD) associated with human obesity, which is a multifactorial syndrome and whose underlying mechanisms are beginning to ..
  80. ncbi The metabolic syndrome as a predictor of nonalcoholic fatty liver disease
    Masahide Hamaguchi
    Department of Gastroenterology, Asahi University, Murakami Memorial Hospital, Gifu, Japan
    Ann Intern Med 143:722-8. 2005
    The frequent association of nonalcoholic fatty liver disease with components of the metabolic syndrome such as obesity, hyperglycemia, dyslipidemia, and hypertension is well known...
  81. ncbi Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    Vlad Ratziu
    Service d Hepatogastroenterologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Gastroenterology 128:1898-906. 2005
    In nonalcoholic fatty liver disease (NAFLD), the distinction between steatosis and steatohepatitis (NASH) and the assessment of the severity of the disease rely on liver histology alone...
  82. pmc Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    Xiong Ma
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Hepatol 49:821-30. 2008
    ..In the current study, we evaluated the effect of probiotics, and their mechanisms on diet-induced obesity, steatosis and insulin resistance...
  83. pmc Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas
    Ya Wen Teng
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:36258-67. 2011
    ..A lack of Bhmt also affects susceptibility to fatty liver and hepatocellular carcinoma...
  84. ncbi Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    Zhiping Li
    The Johns Hopkins University, Baltimore, MD 21205, USA
    Hepatology 37:343-50. 2003
    Ob/ob mice, a model for nonalcoholic fatty liver disease (NAFLD), develop intestinal bacterial overgrowth and overexpress tumor necrosis factor alpha (TNF-alpha)...
  85. pmc PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    Elizabeth K Speliotes
    Department of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Hepatology 52:904-12. 2010
    ..In this study we aim to test whether these SNPs influence the risk of histologically-confirmed nonalcoholic fatty liver disease (NAFLD)...
  86. doi Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
    Nina F Schwenzer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 72076 Tubingen, Germany
    J Hepatol 51:433-45. 2009
    ..The two most common conditions associated with fatty liver are alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD)...
  87. pmc Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study
    Ariel E Feldstein
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 50:1072-8. 2009
    ..Our cohort consisted of 139 patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) from eight CRN participant centers across the United States and 150 age-matched healthy ..
  88. doi Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace
    GYORGY BAFFY
    VA Boston Healthcare System and Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Hepatol 56:1384-91. 2012
    ..HCC has recently been linked to non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity and related metabolic disorders such as diabetes...
  89. ncbi Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    L E Adinolfi
    Internal Medicine and Hepatology, Second University of Naples, Naples, Italy
    Hepatology 33:1358-64. 2001
    ..05). Our data indicate that steatosis is an important cofactor in increasing liver necroinflammatory activity and in accelerating fibrosis in CHC. Visceral obesity and genotype 3a play a role in the development of steatosis...
  90. ncbi Nonalcoholic steatohepatitis: definition and pathology
    E M Brunt
    Department of Pathology, 4th Floor, Saint Louis University Hospital, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 21:3-16. 2001
    ..A histological "grading and staging" system has been developed to reflect the unique features of steatohepatitis, gradations of severity and fibrosis, and to promote uniform reporting of the histopathology...
  91. doi Adipokines in liver diseases
    Fabio Marra
    Department of Internal Medicine, University of Florence, Florence, Italy
    Hepatology 50:957-69. 2009
    ..Several studies have investigated plasma levels of adiponectin in patients with nonalcoholic fatty liver disease, to establish correlations with the underlying state of insulin resistance and with the type and ..
  92. doi Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    Kristiaan Wouters
    Department of Molecular Genetics, Physiology and Electron Microscopy Unit, Nutrition and Toxicology Research and Cardiovascular Research, Institutes of Maastricht University, Maastricht, The Netherlands
    Hepatology 48:474-86. 2008
    ..Omitting cholesterol from the HFC diet lowered plasma VLDL cholesterol and prevented the development of inflammation and hepatic foam cells...
  93. doi Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis
    Amalia Gastaldelli
    Diabetes Division, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Hepatology 50:1087-93. 2009
    ..02 versus placebo). Adipo-IR decreased by 47% and correlated with the reduction of hepatic fat (r=0.46, P=0.009) and with the reduction in hepatic necroinflammation (r=0.47, P=0.0007)...
  94. ncbi Prevalence of and risk factors for fatty liver in a general population of Shanghai, China
    Jian Gao Fan
    Center for Fatty Liver, Shanghai First People s Hospital, Jiaotong University, Shanghai, China
    J Hepatol 43:508-14. 2005
    To determine the prevalence and risk factors of fatty liver (FL) among Shanghai adults.
  95. pmc MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    Hajime Kanda
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:1494-505. 2006
    ..These findings suggest that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice...
  96. doi Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    Giovanni Musso
    Gradenigo Hospital, 10132 Turin, Italy
    Prog Lipid Res 48:1-26. 2009
    Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and is considered the hepatic manifestation of metabolic syndrome...
  97. ncbi Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    Ariel E Feldstein
    Department of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 40:185-94. 2004
    Nonalcoholic fatty liver disease (NAFLD) is a serious health problem. Although NAFLD represents a form of lipotoxicity, its pathogenesis remains poorly understood...
  98. ncbi Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    Kanji Yamaguchi
    Division of Gastroenterology, Duke University Medical Center, 595 LaSalle Street, Durham, NC 27710, USA
    Hepatology 45:1366-74. 2007
    In the early stages of nonalcoholic fatty liver disease (NAFLD), triglycerides accumulate in hepatocytes. Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in hepatocyte triglyceride biosynthesis...
  99. doi Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes
    Anna Ludovica Fracanzani
    Department of Internal Medicine, Scientific Institute of Recovery and Cure Foundation IRCCS, Hospital Maggiore Policlinico, University of Milan, Milan, Italy
    Hepatology 48:792-8. 2008
    It is uncertain whether patients with nonalcoholic fatty liver disease (NAFLD) and normal alanine aminotransferase (ALT) have a milder disease and should undergo liver biopsy...
  100. pmc GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    Hélène L Kammoun
    INSERM, UMR S, Centre de Recherche des Cordeliers, Paris, France
    J Clin Invest 119:1201-15. 2009
    ..These findings demonstrate that GRP78 inhibits both insulin-dependent and ER stress-dependent SREBP-1c proteolytic cleavage and explain the role of ER stress in hepatic steatosis in obese rodents...
  101. pmc Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    Harmeet Malhi
    Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA
    Semin Liver Dis 28:360-9. 2008
    Nonalcoholic fatty liver disease (NAFLD) is characterized by insulin resistance, which results in elevated serum concentration of free fatty acids (FFAs)...

Research Grants68

  1. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..PROJECT NARRATIVE Hepatic steatosis, the accumulation of fat in the liver, is a common feature of nonalcoholic fatty liver disease (NAFLD) that occurs in 14 to 20% of the US population [63]...
  2. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..occurs in MAT1A knockout (KO) mice, which exhibit increased propensity to choline-deficient diet induced fatty liver, higher level of lipid peroxidation, spontaneous development of steatohepatitis and HCC...
  3. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..addition to chronic HBV, other chronic liver disease etiologies including chronic hepatitis C, non- alcoholic fatty liver disease and autoimmune hepatitis have been shown to cause substantial morbidity and mortality among Alaska ..
  4. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..invariably followed the formation of microvesicular and macrovesicular lipid droplets indicating nonalcoholic fatty liver disease (NAFLD) and inflammatory changes resembling non-alcoholic steatohepatitis (NASH)...
  5. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..metabolic syndrome have increased hepatic triglycerides (TG) (steatosis) that predisposes them to non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) for which there is no consensus treatment...
  6. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..Hepatic steatosis directly contributes to insulin resistance and non-alcoholic fatty liver disease (NAFLD)...
  7. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..Persistent hepatic injury occurs during viral hepatitis, fatty liver disease (steatohepatitis), drug or alcohol and autoimmune induced hepatitis...
  8. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..Obese humans with diabetes (NIDDM), metabolic syndrome (MetS) or non-alcoholic fatty liver disease (NAFLD), however, have low a low ratio of 20:4w6 relative to 18:2w6 in plasma and liver when compared ..
  9. Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid Metabolism
    HUIPING ROSE ZHOU; Fiscal Year: 2013
    ..insights into the pathophysiology of dyslipidemia and other metabolic diseases including non-alcoholic fatty liver disease (NAFLD)...
  10. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary Alcoholic liver diseases (ALD) -- ranging from alcoholic fatty liver to alcohol-induced liver fibrosis and cirrhosis - - account for more than 50% of all chronic liver diseases in ..
  11. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are rapidly becoming the commonest reason patients in the United States seek advice from a gastroenterologist...
  12. Role of GDNF in the regulation of hepatic steatosis
    SHANTHI K SRINIVASAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in Veterans and its prevalence continues to increase, with the growing obesity epidemic...
  13. DNA Repair Deficiency Associated with Obesity and the Metabolic Syndrome
    R Stephen Lloyd; Fiscal Year: 2013
    ..to be a common causative factor in the etiology of several human diseases including, but not limited to, fatty liver disease, dyslipidemia, insulin-resistant type 2 diabetes, cardiovascular disease/hypertension, and obesity (..
  14. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2012
    ..Preliminary data showed that liver DNA is not globally hypermethylated. These -/- mice spontaneously develop fatty liver. Our First Hypothesis is that extra-hepatic tissues from -/- animals with high levels of glycine N- ..
  15. Hepatic Steatosis and ER Stress-Inducible Transcription Factor CREBH
    Kezhong Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatic steatosis or fatty liver is considered the key metabolic precursor to non-alcoholic fatty liver disease (NAFLD), the major cause of liver-associated illness and death in the United States...
  16. Role of Membrane Modifications in the Bioactivities of Conjugated Linoleic Acids
    Papasani V Subbaiah; Fiscal Year: 2013
    ..However, they are also known to cause undesirable effects such as insulin resistance and fatty liver in certain species but not others. Despite extensive studies, the mechanism of action of CLA is largely unknown...
  17. Hormonal regulation of a Ca2+/AMPK signaling pathway
    Anthony R Means; Fiscal Year: 2013
    ..Because inflammation is such a prevalent cause of or response to numerous human diseases we believe our studies will reveal CaMKK2 to be an important, novel target for therapeutic intervention. ..
  18. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..the interaction between lipid metabolism and chronic liver disease, specifically hepatitis C and non-alcoholic fatty liver disease (NAFLD)...
  19. Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic Links
    SHIKHA SEKSARIA SUNDARAM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is the most common chronic pediatric liver disease and may progress to an aggressive necro-inflammatory disease (NASH) that leads to fibrosis and cirrhosis ..
  20. Lipid Transport, Bile Acid Synthesis, and Cholesterol Homeostasis
    William M Pandak; Fiscal Year: 2013
    ..In particular, nonalcoholic fatty liver disease (NAFLD) is a disorder of hepatic lipid homeostasis in which both cholesterol and triglycerides ..
  21. Metabolic impact of fructose restriction in obese children
    Jean Marc Schwarz; Fiscal Year: 2013
    ..Obese Latino children exhibit the highest prevalence of dyslipidemia, visceral adiposity, and non-alcoholic fatty liver disease (NAFLD);African American children present instead with hypertension, worsened insulin resistance, and ..
  22. NPC1L1 and Metabolic Diseases
    Liqing Yu; Fiscal Year: 2013
    ..identical between wild-type (WT) and NPC1L1 knockout (L1KO) mice, yet L1KO mice were protected against DIO and fatty liver, which was associated with increased expression of genes promoting energy expenditure in brown adipose tissue (..
  23. Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2
    David E Cohen; Fiscal Year: 2013
    ..insulin resistance due to obesity is central to the pathogenesis of common disorders including non- alcoholic fatty liver disease (NAFLD)...
  24. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
    ..of obesity-induced adipocyte dysfunction and complications, including type 2 diabetes, non-alcoholic fatty liver disease and dyslipidemia...
  25. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..The specific aims of the proposal are: Aim 1. Investigate the role of miR-122 in a mouse model of nonalcoholic fatty liver disease (NAFLD) related HCC induced by feeding choline-deficient diet...
  26. Effect of HIV protease inhibitor on alcohol induced ER stress and liver injury.
    Cheng Ji; Fiscal Year: 2013
    ..been shown to play an essential role in liver dysfunction including necroinflammation, hepatic cell death and fatty liver. We previously observed that alcohol consumption, which is a well-recognized co-factor in susceptibility to the ..
  27. UT GASTROENTEROLOGY / HEPATOLOGY RESEARCH TRAINING PROGRAM
    Ezra Burstein; Fiscal Year: 2013
    ..Altogether, this program is designed to train individuals who will be effective investigators and academic leaders in the fields of Gastroenterology and Hepatology. ..
  28. Metabolic Crosstalk Between Immune Cells and the Liver in Obesity
    BENJAMIN MANTELL; Fiscal Year: 2012
    ..Both are associated with significant levels of morbidity and mortality;they are leading causes of non-alcoholic fatty liver disease, blindness, kidney failure and non-traumatic amputations, and these patients are also at increased risk ..
  29. Mechanisms and Consequences of Intermittent Hypoxia-Induced Lipolysis
    Jonathan C Jun; Fiscal Year: 2013
    ..are circulating lipids released by adipose tissue during lipolysis, which in excess induce insulin resistance, fatty liver, and hyperlipidemia...
  30. Inactivation of Hdac3 in the cause, prevention, and treatment of HCC
    Scott W Hiebert; Fiscal Year: 2013
    ..Removal of Hdac3 in the mouse liver caused a phenotype similar to non-alcoholic fatty liver disease, which was likely due to de- regulated nuclear hormone receptor functions...
  31. Novel PPAR-Independent Peroxisome Proliferators for Type 2 Diabetes
    LIDIA NIEROBISZ; Fiscal Year: 2011
    ..fatty acids lead to ectopic harmful lipid accumulation in non-adipose tissue, particularly in the liver ("fatty liver") resulting in impaired metabolic function...
  32. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..HCV infection also correlates with high prevalence of fatty liver (steatosis) in patients, which may account for many metabolic disorders such as insulin resistance and diabetes ..
  33. Role of inflammation and cellular stress in the pathogenesis of type 2 diabetes
    Liangyou Rui; Fiscal Year: 2013
    ..and activated NF- B2 levels were increased in the livers of mice with obesity and humans with alcoholic fatty liver disease or hepatitis C...
  34. Phospholipid-Mediated Metabolic Control in Liver and Brown Adipose Tissue
    David E Cohen; Fiscal Year: 2013
    ..of insulin resistance and obesity, is central to the pathogenesis of common disorders including non-alcoholic fatty liver disease (NAFLD)...
  35. Remodeling of Lipid Metabolism by Dietary Methionine Restriction
    ERIC PAUL PLAISANCE; Fiscal Year: 2012
    ..liver and adipose tissue are necessary for increasing metabolism and 3) if MR decreases pre- existing obesity, fatty liver and insulin resistance in adult mice...
  36. Mechanisms and metabolic implications of LRP130 in NAFLD
    Marcus P Cooper; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in the United States...
  37. Lipid Metabolism and Steatosis in Liver
    Amrita Kamat; Fiscal Year: 2013
    ..by applicant): Excessive lipid accumulation in the liver (hepatic steatosis) is a hallmark of nonalcoholic fatty liver disease (NAFLD), which contributes to insulin resistance, type 2 diabetes, and cardiovascular disease...
  38. Novel Small Molecule Therapeutics to Treat Obesity
    SUSAN MEDGHALCHI; Fiscal Year: 2010
    ..FASgen has developed the first pharmacological inhibitors of GPAT that are effective in reducing weight in diet-induced obese mice. This grant will enable FASgen to rapidly move these compounds toward drug development. ..
  39. NAFLD in T2DM: Prevalence in Hispanics and Role of Treatment
    Kenneth Cusi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is a chronic liver condition characterized by insulin resistance and hepatic fat accumulation (steatosis)...
  40. MLK3 in metabolic stress signaling
    Anja Jaeschke; Fiscal Year: 2013
    ..that is associated with metabolic syndrome, including insulin resistance and the development of non-alcoholic fatty liver disease (NAFLD). NAFLD is characterized by hepatic steatosis and varying degrees of inflammation and fibrosis...
  41. INSULIN ACTION IN MUSCLE AND FAT CELLS
    JAMES CARLTON GARRISON; Fiscal Year: 2010
    ..Lpn1fld/fld mice exhibit fatty liver, defective adipogenesis, glucose intolerance and insulin resistance...
  42. Cellular Mechanisms for Increased Gluconeogenesis in Type 2 Diabetes
    Varman T Samuel; Fiscal Year: 2013
    ..We show that knockdown of PEPCK in high-fat fed rats protects against adiposity but leads to nonalcoholic fatty liver disease and hepatic insulin resistance, akin to a mild lipodystrophy...
  43. REGULATION OF 15N UREA ISOTOPOMERS PRODUCTION
    Itzhak Nissim; Fiscal Year: 2013
    ..in disorders of congenital defects of the urea cycle and of fatty acid oxidation (FAO), nonalcoholic fatty liver disease (NAFLD) and/or "Metabolic Syndrome" (MS)...
  44. The Role of Cyp2b in Toxicant Metabolism and Sensitivity
    William S Baldwin; Fiscal Year: 2012
    ..whether mice with low Cyp2b activity are susceptible to high-fat diet (Western diet) induced hepatic steatosis (fatty liver) and obesity...
  45. Control of liver autophagy by phosphatidic acid signaling
    GILBERT DIPAOLO; Fiscal Year: 2013
    ..role of macrolipophagy in the control of lipid metabolism and provide the basis for future work testing whether stimulating the PLD1 pathway can be exploited to promote macrolipophagy in human conditions, such as fatty liver diseases.
  46. Insulin resistance in the pathogenesis of NASH
    SONIA MICHAEL NAJJAR; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): About one third of adults in the United States are diagnosed with fatty liver disease. About 10% will proceed to develop nonalcoholic steatohepatitis (NASH), and associated co-morbidities...
  47. Translational Research and Evolving Alcoholic hepatitis Treatment (TREAT-IU)
    David W Crabb; Fiscal Year: 2013
    ..impairs gut integrity, permits activation of Kupffer cells, enhances oxidative stress in the liver, stimulates fatty liver, and sensitizes hepatocytes to cytokine-induced necroapoptosis, and that these abnormalities can be reversed ..
  48. GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASE
    Rohit Loomba; Fiscal Year: 2013
    ..long-term goal is to develop an independent research career in the genetic epidemiology of nonalcoholic fatty liver disease (NAFLD) by combining patient- centered research with clinical epidemiology...
  49. Systemic Factors that Maintain a Young Liver Phenotype
    Roy G Smith; Fiscal Year: 2012
    ..Ghrelin levels decline as a function of age. Our research is designed to test whether replacing this hormone with a more stable form will provide health and quality of life benefits during aging. ..
  50. Mechanisms of ER stress - induced fatty liver
    D Thomas Rutkowski; Fiscal Year: 2013
    Item 6. Project Summary/Abstract Fatty liver disease (FLD) has a variety of causes including chronic alcohol consumption, obesity, viral infection, malnutrition, and acute exposure to hepatotoxins...
  51. Mechanisms of glucagon-like peptide 1 (GLP-1) in fatty liver disease
    Frank A Anania; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a major health concern among US veterans...
  52. Role of aberrant organelle stress responses in alcohol-induced liver injury
    Cheng Ji; Fiscal Year: 2012
    ..ER stress responses contribute to liver injury including hepatic necroinflammation and cell death and severe fatty liver leading to fibrosis and cirrhosis...
  53. Mechanisms of Lipid-Induced Hepatic Insulin Resistance
    Gerald I Shulman; Fiscal Year: 2013
    ..Recent studies in both humans and rodent models of non alcoholic fatty liver disease (NAFLD) have led to a unifying diacylglycerol-hypothesis (DAG-hypothesis) for lipid-induced hepatic ..
  54. Visceral Adiposity, HIV, and HCV: Biologic Mediators of Hepatic Steatosis
    Phyllis C Tien; Fiscal Year: 2013
    ..Hepatic steatosis (or fatty liver) is common in HIV infection and is associated with accelerated fibrosis progression, which can lead to ..
  55. MIF in progression and treatment of ALD
    Laura E Nagy; Fiscal Year: 2013
    ..b>Fatty liver occurs in up to 90% of alcoholics, but only a subset of heavy drinkers progress to more severe injury...
  56. The Intestinal Microbiome in Pediatric NAFLD
    Nita H Salzman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The prevalence of non-alcoholic fatty liver disease (NAFLD) and its severe phenotype, non-alcoholic steatohepatitis (NASH), are increasing significantly in the United States in the adult and pediatric ..
  57. Development of PAR2 Inhibitors for the Treatment of Nonalcoholic steatohepatitis
    Athan Kuliopulos; Fiscal Year: 2013
    ..PZ-235 reduces fatty liver steatosis and hypertriglyceridemia by up to 50%, and suppresses lobular inflammation and systemic alanine ..
  58. Dissecting the Role of Unfolded Protein Response in Alcoholic Liver Disease
    Ling Qi; Fiscal Year: 2013
    ..Alcoholic fatty liver disease, or steatosis, is one of the earliest and most common consequences of excess alcohol consumption and ..
  59. Pathogenic Mechanisms of Fatty Liver Disease
    Mohammad S Siddiqui; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disorders (NAFLD) are the most common cause of abnormal serum liver chemistry tests in the United States and are the leading causes of cryptogenic cirrhosis...
  60. Hepatic Non-viral Gene Therapy
    Leaf Huang; Fiscal Year: 2013
    ..The mice can be infected by HBV and develop hepatitis symptoms, including fatty liver, fibrosis and inflammation...
  61. REGULATION OF 15N UREA ISOTOPOMERS PRODUCTION
    Itzhak Nissim; Fiscal Year: 2009
    ..to inborn errors of the urea cycle, treatment with certain drugs or faulty hepatic fatty acid oxidation (FAO), fatty liver or "Metabolic Syndrome" (MS)...
  62. Regulation of cholesterol catabolism by bile acids
    Jongsook Kim Kemper; Fiscal Year: 2013
    ..Obesity is a growing epidemic worldwide. Fatty liver (steatosis) that develops in obese people increases the risk for diabetes, heart disease, and even, liver ..
  63. Characterizing Alcohol's Effects on Repair of Liver Injury
    ANNA MAE ELIZABETH DIEHL; Fiscal Year: 2010
    ..g., nonalcoholic fatty liver disease - NAFLD) but accelerates the evolution of cirrhosis in others (e.g., chronic hepatitis C - HCV)...
  64. Diagnosing and monitoring NAFLD using unbound FFA profiles
    Alan Kleinfeld; Fiscal Year: 2009
    ..to develop a rapid, non-invasive and inexpensive diagnostic assay to detect and possibly stage non-alcoholic fatty liver disease (NAFLD)...
  65. Adiponectin effects on leptin signaling in hepatocellular carcinoma
    Neeraj Kumar Saxena; Fiscal Year: 2011
    ..This association might represent the progression of underlying nonalcoholic fatty liver disease (NAFLD) to cirrhosis and hepatocellular carcinoma in obese patients although no study has clearly ..
  66. Ethanol-Induced VDAC Closure in Hepatocytes
    Ekhson Holmuhamedov; Fiscal Year: 2007
    ..glycolysis, glycogen depletion, inhibition of mitochondrial oxidation of medium and long chain fatty acids, and fatty liver changes (steatosis)...
  67. Priming of liver disease by arsenic exposure
    Gavin E Arteel; Fiscal Year: 2010
    ..hypothesis that low-dose arsenic exposure sensitizes liver to hepatotoxicity in mouse models of non alcoholic fatty liver disease (NAFLD). A liver disease that is currently endemic to the US population is obesity-induced NAFLD...
  68. Analysis of Fatty Liver in the Framingham Heart Study Cohort
    ELIZABETH SPELIOTES; Fiscal Year: 2007
    ..in obesity has been accompanied by an increase in diabetes, hypertension, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD). NAFLD can result in liver cirrhosis and eventual liver failure...