stomach ulcer

Summary

Summary: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Top Publications

  1. ncbi Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats
    S Q Wasman
    Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Teknologi Malaysia, 81310, UTM Skudai, Johor, Malaysia
    Indian J Exp Biol 49:767-72. 2011
  2. ncbi Gastric mucosal defense and cytoprotection: bench to bedside
    Loren Laine
    Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Gastroenterology 135:41-60. 2008
  3. ncbi Antioxidant properties of natural compounds used in popular medicine for gastric ulcers
    M G Repetto
    Laboratorio de Estrés Oxidativo en Patologías Humanas, Catedra de Quimica General e Inorganica, Departamento de Química Analítica y Fisicoquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Braz J Med Biol Res 35:523-34. 2002
  4. ncbi A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical
    Kaushik Biswas
    Department of Physiology, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700 032, India
    J Biol Chem 278:10993-1001. 2003
  5. pmc Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility
    Koji Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    World J Gastroenterol 18:2147-60. 2012
  6. ncbi Acute toxicity and gastroprotective effect of the Schiff base ligand ¹H-indole-3-ethylene-5-nitrosalicylaldimine and its nickel (II) complex on ethanol induced gastric lesions in rats
    Mohamed Mustafa Ibrahim
    Department of Chemistry, University of Hail, Hail 81451, Saudi Arabia
    Molecules 17:12449-59. 2012
  7. ncbi Antiulcerogenic and analgesic effects of Maytenus aquifolium, Sorocea bomplandii and Zolernia ilicifolia
    F G Gonzalez
    , Departamento de Farmacologia, , Unesp. Botucatu, SP, CEP 18618-000, Brazil
    J Ethnopharmacol 77:41-7. 2001
  8. ncbi Gastric antisecretory and antiulcer effects of simvastatin in rats
    Mohammad Tariq
    Research Center, Armed Forces Hospital, Riyadh, Saudi Arabia
    J Gastroenterol Hepatol 22:2316-23. 2007
  9. ncbi Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole
    David Y Graham
    Veterans Affairs Medical Center 111D, 2002 Holcombe Blvd, Room 3A 320, Houston, TX 77030 4211, USA
    Arch Intern Med 162:169-75. 2002
  10. ncbi Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia
    R M Jorge
    Laboratorio de Toxicologia Experimental, Faculdade de Farmacia, UFMG, Av Olegário Maciel, 2360 613, 30180 112, Belo Horizonte, MG, Brazil
    J Ethnopharmacol 94:93-100. 2004

Research Grants

Detail Information

Publications279 found, 100 shown here

  1. ncbi Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats
    S Q Wasman
    Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Teknologi Malaysia, 81310, UTM Skudai, Johor, Malaysia
    Indian J Exp Biol 49:767-72. 2011
    ..65. Results of this study showed that pretreatment with ethonolic extract of A. paniculata ethanolic provided significant protection against gastric ulcer by regulating of pH, mucous production and antioxidant property...
  2. ncbi Gastric mucosal defense and cytoprotection: bench to bedside
    Loren Laine
    Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Gastroenterology 135:41-60. 2008
    ..Pharmacologic therapy with antisecretory drugs may be used in high-risk patients (eg, mechanical ventilation >or=48 hours), although the absolute risk reduction is small, and a decrease in mortality is not documented...
  3. ncbi Antioxidant properties of natural compounds used in popular medicine for gastric ulcers
    M G Repetto
    Laboratorio de Estrés Oxidativo en Patologías Humanas, Catedra de Quimica General e Inorganica, Departamento de Química Analítica y Fisicoquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Braz J Med Biol Res 35:523-34. 2002
    ..In this review article, we shall consider the role of natural antioxidants derived from popular plants to reduce or prevent the oxidative stress in gastric ulcer induced by ethanol...
  4. ncbi A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical
    Kaushik Biswas
    Department of Physiology, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700 032, India
    J Biol Chem 278:10993-1001. 2003
    ..Thus, omeprazole plays a significant role in gastroprotection by acting as a potent antioxidant and antiapoptotic molecule...
  5. pmc Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility
    Koji Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    World J Gastroenterol 18:2147-60. 2012
    ....
  6. ncbi Acute toxicity and gastroprotective effect of the Schiff base ligand ¹H-indole-3-ethylene-5-nitrosalicylaldimine and its nickel (II) complex on ethanol induced gastric lesions in rats
    Mohamed Mustafa Ibrahim
    Department of Chemistry, University of Hail, Hail 81451, Saudi Arabia
    Molecules 17:12449-59. 2012
    ..Research finding suggest that TNS and its nickel (II) complex could be considered as effective gastroprotective compounds...
  7. ncbi Antiulcerogenic and analgesic effects of Maytenus aquifolium, Sorocea bomplandii and Zolernia ilicifolia
    F G Gonzalez
    , Departamento de Farmacologia, , Unesp. Botucatu, SP, CEP 18618-000, Brazil
    J Ethnopharmacol 77:41-7. 2001
    ..Pre-treatment with Zolernia ilicifolia induced someone toxic effects. A phytochemical profile for each plant species was determined and its main chemical classes of compounds were described...
  8. ncbi Gastric antisecretory and antiulcer effects of simvastatin in rats
    Mohammad Tariq
    Research Center, Armed Forces Hospital, Riyadh, Saudi Arabia
    J Gastroenterol Hepatol 22:2316-23. 2007
    ..This investigation aimed to study the effect of SIM on experimentally induced gastric acid secretion and ulcer formation...
  9. ncbi Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole
    David Y Graham
    Veterans Affairs Medical Center 111D, 2002 Holcombe Blvd, Room 3A 320, Houston, TX 77030 4211, USA
    Arch Intern Med 162:169-75. 2002
    ....
  10. ncbi Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia
    R M Jorge
    Laboratorio de Toxicologia Experimental, Faculdade de Farmacia, UFMG, Av Olegário Maciel, 2360 613, 30180 112, Belo Horizonte, MG, Brazil
    J Ethnopharmacol 94:93-100. 2004
    ....
  11. ncbi Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy
    Pharmacol Res 59:90-100. 2009
    ....
  12. ncbi The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats
    S Singh
    Department of Pharmacology, Indian Institute of Integrative Medicine CSIR, Canal Road Jammu Tawi, J and K 180001, India
    Phytomedicine 15:408-15. 2008
    ..Nevertheless it is possible that BA might be acting by increasing the gastric mucosal resistance and local synthesis of cytoprotective prostaglandins and inhibiting the leukotriene synthesis...
  13. ncbi Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin
    D Bandyopadhyay
    Department of Physiology, Indian Institute of Chemical Biology, Calcutta
    Curr Mol Med 1:501-13. 2001
    ..Finally, we include a commentary on how melatonin research with respect to gastric pathophysiology can move forward with a view of eventually using this indole as a therapeutic agent to control gastric ulceration in humans...
  14. ncbi Gastric and duodenal antiulcer activity of alkaloids: a review
    Heloina de Sousa Falcão
    Laboratorio de Tecnologia Farmaceutica, Universidade Federal da Paraiba, UFPB, Joao Pessoa, PB, Brazil
    Molecules 13:3198-223. 2008
    ..In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals...
  15. ncbi Antiulcerogenic activity of hydroalcoholic extract of Achillea millefolium L.: involvement of the antioxidant system
    Francine Bittencourt Potrich
    Department of Pharmacology, Universidade Federal do Parana, Curitiba, PR, Brazil
    J Ethnopharmacol 130:85-92. 2010
    ....
  16. ncbi Flexible endoscopy in the management of patients undergoing Roux-en-Y gastric bypass
    Bruce Schirmer
    University of Virginia Health System, Charlottesville, VA, USA
    Obes Surg 12:634-8. 2002
    ..Flexible upper endoscopy (FUE) is an important diagnostic and therapeutic tool in the management of upper gastrointestinal diseases. We examined the role of FUE in the management of patients undergoing Roux-en-Y gastric bypass (RYGBP)...
  17. ncbi Risk factors associated with equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark
    N Luthersson
    Hestedoktoren I S, 4360 Kr Eskilstrup, Denmark
    Equine Vet J 41:625-30. 2009
    ..However, there have been few studies to confirm these findings in nonracehorses in Europe...
  18. ncbi Stress-related mucosal disease: risk factors and prophylactic therapy
    Mitchell J Spirt
    Division of Gastroenterology, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Clin Ther 26:197-213. 2004
    ..Caused by mucosal ischemia, SRMD is most commonly seen in critically ill patients in the intensive care unit (ICU). Prophylaxis of stress ulcers may reduce major bleeding but has not yet been shown to improve survival...
  19. ncbi Effect of sesame oil on acidified ethanol-induced gastric mucosal injury in rats
    Dur Zong Hsu
    Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan
    JPEN J Parenter Enteral Nutr 33:423-7. 2009
    ..The aim of this study was to investigate the effect of sesame oil on acidified ethanol-induced gastric mucosal damage in rats...
  20. ncbi Helicobacter pylori is a risk factor for peptic ulcer disease in cirrhotic patients. A meta-analysis
    Mercedes Vergara
    Unitat de Malalties Digestives, Corporacio Parc Tauli, Parc Tauli s n, 08208 Sabadell, Barcelona, Spain
    Eur J Gastroenterol Hepatol 14:717-22. 2002
    ..Helicobacter pylori infection is considered the chief aetiological factor of ulcer disease. However, in cirrhotic patients the role of H. pylori in the pathogenesis of peptic ulcer remains uncertain...
  21. pmc Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)
    John L Wallace
    Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Br J Pharmacol 159:1236-46. 2010
    ..We evaluated the gastrointestinal safety and anti-inflammatory efficacy of a novel hydrogen sulphide-releasing derivative of naproxen, ATB-346 [2-(6-methoxy-napthalen-2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester]...
  22. ncbi Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection
    Marcio Adriano Andreo
    Departamento de Quimica Organica, Instituto de Quimica, CP 355, CEP 14801 970, UNESP, Sao Paulo State University, Araraquara, SP, Brasil
    J Ethnopharmacol 107:431-41. 2006
    ..The presence of these phenolic compounds probably would explain the antiulcerogenic effect of the polar extract of Mouriri pusa leaves...
  23. ncbi Gastric ulcers in standardbred racehorses: prevalence, lesion description, and risk factors
    Rachel M Dionne
    From the Département de sciences cliniques, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    J Vet Intern Med 17:218-22. 2003
    ..The cause-and-effect relationship between poor body condition and the presence of gastric ulcers is unclear...
  24. ncbi Mucosal repair and COX-2 inhibition
    Rafael F Perini
    Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Curr Pharm Des 9:2207-11. 2003
    ..Given the importance of COX-2 in regulating ulcer healing, caution should be taken in the use of selective inhibitors of COX-2 by patients at risk of ulcer disease...
  25. ncbi Leptin promotes gastric ulcer healing via upregulation of vascular endothelial growth factor
    Tetsuya Tanigawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan ttanigawa med osaka cu ac jp
    Digestion 81:86-95. 2010
    ..Its role in gastric ulcer healing is unclear. In this study, we investigated the role of leptin in gastric ulcer healing...
  26. ncbi Synthesis, hydrolysis studies and phamacodynamic profiles of amide prodrugs of dexibuprofen with amino acids
    Arun Rasheed
    Department of Pharmaceutical Chemistry, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati, Andhra Pradesh, India
    J Enzyme Inhib Med Chem 26:688-95. 2011
    ..The histopathological studies revealed less ulceration in the gastric region when treated with prodrugs. Thus, the prodrugs were proved to be better in action as compared with the parent drug...
  27. ncbi Association between genetic polymorphisms in the cyclooxygenase-1 gene promoter and peptic ulcers in Japan
    Tomiyasu Arisawa
    Department of Gatroenterology, Fujita Health University School of Medicine, Toyoake 470 1192, Japan
    Int J Mol Med 20:373-8. 2007
    ....
  28. pmc Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil
    K Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Exp Med 192:1601-10. 2000
    ..In conclusion, the knocking out of the cagE gene deprived wild-type H. pylori of the pathogenicity for gastritis and gastric ulcer, suggesting that the secretion system encoded by cag pathogenicity island genes plays an essential role...
  29. ncbi Synbiotic (probiotic and ginger extract) loaded floating beads: a novel therapeutic option in an experimental paradigm of gastric ulcer
    Pramod Kumar Singh
    University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh, India
    J Pharm Pharmacol 64:207-17. 2012
    ..Packaging probiotics in a suitably designed pharmaceutical system with GE may facilitate their establishment in the stomach mucosa...
  30. ncbi Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats
    G Sener-Muratoğlu
    Marmara University School of Pharmacy, Department of Pharmacology, Haydarpasa, Istanbul, Turkey
    Dig Dis Sci 46:318-30. 2001
    ..On the other hand, the antisecretory effect of omeprazole and famotidine may also be contributing to their antiulcer effect...
  31. ncbi Gastroprotective activity of Cinnamomum tamala leaves on experimental gastric ulcers in rats
    M Bavani Eswaran
    Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute CSIR, Rana Pratap Marg, Lucknow 226 001, Uttar Pradesh, India
    J Ethnopharmacol 128:537-40. 2010
    ..Cinnamomum tamala T. Nees & Eberm (Family Lauraceae) is used traditionally in Indian System of Medicine as carminative, anthelmintic, diuretic, and used in colic, dyspepsia, and diarrhea...
  32. ncbi Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models
    Sergio Faloni de Andrade
    Programa de Mestrado em Ciências Farmacêuticas, Núcleo de Investigações Químico Farmacêuticas NIQFAR, Universidade do Vale do Itajai UNIVALI, Itajai, Santa Catarina, Brazil
    J Ethnopharmacol 113:252-7. 2007
    ..This work also corroborates the traditional indication of Maytenus robusta, contributing to its pharmacological validation...
  33. ncbi Antiulcerogenic activity of four extracts obtained from the bark wood of Quassia amara L. (Simaroubaceae)
    Walber Toma
    Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas, Sao Paulo, Brazil
    Biol Pharm Bull 25:1151-5. 2002
    ....
  34. ncbi Experimental gastric mucosal injury: laboratory models reveal mechanisms of pathogenesis and new therapeutic strategies
    G B Glavin
    Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
    FASEB J 6:825-31. 1992
    ..Growing realization that factors other than gastric secretion contribute significantly to the development of gastric ulcer disease prompts the conclusion that these same factors represent viable treatment alternatives...
  35. ncbi Anti-ulcer and antioxidant activity of DHC-1, a herbal formulation
    P A Bafna
    Department of Pharmacy, Faculty of Technology and Engineering, MSUniversity of Baroda, Baroda 390001, Gujarat, India
    J Ethnopharmacol 90:123-7. 2004
    ..Thus, it can be concluded that DHC-1 possesses anti-ulcer activity, which can be attributed to its antioxidant mechanism of action...
  36. ncbi Melatonin and its precursor L-tryptophan prevent acute gastric mucosal damage induced by aspirin in humans
    P C Konturek
    First Department of Medicine, University Erlangen Nuremberg, Germany
    J Physiol Pharmacol 59:67-75. 2008
    ..The action of Trp may be be mediated by MT produced in gastrointestinal tract from Trp. The gastroprotective action of MT and Trp is independent on gastric mucosal PGE2 generation...
  37. ncbi Apple polyphenol extracts prevent aspirin-induced damage to the rat gastric mucosa
    Giuseppe D'Argenio
    Gastroenterologia, Dipartimento di Medicina Clinica e Sperimentale, Universita Federico II, Naples, Italy
    Br J Nutr 100:1228-36. 2008
    ..In conclusion, APE reduces aspirin-induced gastric injury independently of acid inhibition. We speculate that APE might be of therapeutic use in the prophylaxis of aspirin-related gastropathy...
  38. ncbi Alcohol-related diseases of the esophagus and stomach
    Andreas Franke
    Department of Medicine II Gastroenterology, Hepatology, Infectious Diseases, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Dig Dis 23:204-13. 2005
    ..Much research is still needed to clarify the effects of alcohol itself and the byproducts that result during the production of the different types of alcoholic beverages on dismotility and mucosal injury to the esophagus and stomach...
  39. pmc Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue
    Hakan Dursun
    Department of Pharmacology, Ataturk University, Faculty of Medicine, Erzurum, Turkey
    BMC Gastroenterol 9:36. 2009
    ..This study aimed to investigate the antiulcer effects of fluvoxamine and to determine its relationship with antioxidants...
  40. ncbi Endoscopic findings and their clinical correlations in patients with symptoms after gastric bypass surgery
    Christopher S Huang
    Section of Gastroenterology, Department of Surgery, Boston Medical Center, Boston, Massachusetts 02118, USA
    Gastrointest Endosc 58:859-66. 2003
    ..The aim of this study was to describe the endoscopic findings in patients with upper GI symptoms after Roux-en-Y gastric bypass surgery and to correlate clinical features with endoscopic findings...
  41. ncbi Gastroprotective activity of Trichosanthes cucumerina in rats
    L D A M Arawwawala
    Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, Sri Lanka
    J Ethnopharmacol 127:750-4. 2010
    ..The aim of the present study was to scientifically investigate whether Trichosanthes cucumerina Linn (Family: Cucurbitaceae) has gastroprotective activity...
  42. ncbi Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers
    B Berenguer
    Department of Pharmacology, Faculty of Pharmacy, Profesor García González Street No 2, 41012 Seville, Spain
    J Ethnopharmacol 103:194-200. 2006
    ..These results suggest that the gastroprotective effect of Rhizophora mangle in this experimental model appears through an antioxidant and prostaglandin-dependent way...
  43. ncbi Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment
    R Colucci
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Pisa, Italy
    Dig Liver Dis 41:395-405. 2009
    ..The efficacy of proton pump inhibitors in patients at high risk of gastrointestinal injury receiving non-steroidal anti-inflammatory drugs is currently debated...
  44. ncbi Vernonia polyanthes as a new source of antiulcer drugs
    Victor Barbastefano
    Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Cidade Universitaria Zeferino Vaz, S N, CP 6109, CEP13083 970, Campinas, SP, Brazil
    Fitoterapia 78:545-51. 2007
    ..o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action...
  45. ncbi Higher concentration of matrix-metalloproteinase 1 (interstitial collagenase) in H. pylori-compared to NSAID-induced gastric ulcers
    M Menges
    Department of Internal Medicine II, Saarland University, Homburg, Germany
    Z Gastroenterol 38:887-91. 2000
    ..Further, we correlated them with the individual ulcer etiology...
  46. ncbi Protective effect of (+)-catechin against gastric mucosal injury induced by ischaemia-reperfusion in rats
    Ch V Rao
    Gastropharmacology Laboratory, Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Rana Partap Marg, Post Box No 436, Lucknow 226 001, Uttar Pradesh, India
    J Pharm Pharmacol 59:1103-7. 2007
    ..05) and corticosterone (P<0.05). The results suggested that (+)-catechin protected gastric mucosa against ischaemia-reperfusion-induced gastric ulcers by its antioxidant activity and mucus protection...
  47. pmc Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial
    Kentaro Sugano
    Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Gastroenterol 46:724-35. 2011
    ..This study sought to examine the efficacy of low-dose lansoprazole (15 mg once daily) for the secondary prevention of LDA-associated gastric or duodenal ulcers...
  48. ncbi Yogurt containing Lactobacillus gasseri OLL 2716 (LG21 yogurt) accelerated the healing of acetic acid-induced gastric ulcer in rats
    Masayuki Uchida
    Food Science Institute, Division of Research and Development, Meiji Dairies Corporation, Kanagawa, Japan
    Biosci Biotechnol Biochem 74:1891-4. 2010
    ..From the above results, it was found that viable bacteria are needed to accelerate the healing of chronic gastric ulcer, but not to inhibit gastric lesions...
  49. ncbi Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors
    Ryo Hatazawa
    Dept of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical Univ, Misasagi, Yamashina, Kyoto 607, Japan
    Am J Physiol Gastrointest Liver Physiol 293:G788-97. 2007
    ....
  50. ncbi Complicated and uncomplicated peptic ulcers in a Danish county 1993-2002: a population-based cohort study
    Annmarie Lassen
    Department of Medical Gastroenterology, Odense University Hospital, Denmark
    Am J Gastroenterol 101:945-53. 2006
    ..Peptic ulcer epidemiology changes as the proportion of Helicobacter pylori infected people decreases, use of nonsteroidal anti-inflammatory drugs (NSAID) increases, and the proportion of elderly persons increases...
  51. ncbi Long-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: a prospective cohort study
    Lawrence C T Hung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Gastroenterology 128:1845-50. 2005
    ..Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown...
  52. ncbi Trends and outcomes of hospitalizations for peptic ulcer disease in the United States, 1993 to 2006
    Y Richard Wang
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Ann Surg 251:51-8. 2010
    ..The purpose of this study was to quantify the time trends of hospitalizations and operations for PUD in the United States (US) since 1993...
  53. pmc Laparoscopic correction of perforated peptic ulcer: first choice? A review of literature
    Marietta J O E Bertleff
    Department of Plastic and Reconstructive Surgery, Academic Hospital Maastricht, P Debeyelaan 25, 6229 HX, Maastricht, The Netherlands
    Surg Endosc 24:1231-9. 2010
    ....
  54. ncbi Control of gastric acid secretion in health and disease
    Mitchell L Schubert
    Department of Medicine, Division of Gastroenterology, Virginia Commonwealth University s Medical College of Virginia, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 134:1842-60. 2008
    ..We review the physiology and pathophysiology of acid secretion as well as evidence regarding its inhibition in the management of acid-related clinical conditions...
  55. pmc Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats
    Fatih Mehmet Birdane
    Department of Pharmacology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyon, Turkey
    World J Gastroenterol 13:607-11. 2007
    ..To examine the anti-ulcerogenic and antioxidant effects of aqueous extracts of Foeniculum vulgare (FVE) on ethanol-induced gastric lesions in rats...
  56. ncbi Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population
    Luis A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Gastroenterology 132:498-506. 2007
    ..Whether use of selective inhibitors of cyclooxygenase-2 (COXIBs) will translate into a clinically relevant reduced toxicity has not been widely investigated in the general population...
  57. ncbi Gastric antiulcer effect of Rhizophora mangle L
    L M Perera
    Department of Pharmacology and Toxicology, National Center of Plant and Animal Health, CENSA, Apdo 10, San José de las Lajas, Havana, Cuba
    J Ethnopharmacol 77:1-3. 2001
    ..Mucus content was increased and it was accompanied by a proportional increase in proteins. The group, which received cimetidine, showed no effect on the mucus secretion induced in this experimental model...
  58. ncbi Cellular and molecular mechanisms of gastrointestinal ulcer healing
    Andrzej S Tarnawski
    Department of Medicine, VA Long Beach Healthcare System Long Beach, Long Beach, California 90822, USA
    Dig Dis Sci 50:S24-33. 2005
    ..Future directions to accelerate and improve healing include the use of stem cells and tissue engineering...
  59. ncbi Factors that predict morbidity and mortality in patients with perforated peptic ulcers
    Jyrki T Mäkelä
    Department of Surgery, University of Oulu, Oulu, Finland
    Eur J Surg 168:446-51. 2002
    ....
  60. ncbi Gastric cytoprotective anti-ulcer effects of the leaf methanol extract of Ocimum suave (Lamiaceae) in rats
    Paul V Tan
    Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P O Box 812, Yaounde, Cameroon
    J Ethnopharmacol 82:69-74. 2002
    ..These results suggest that a new anti-ulcer therapy regimen may be formulated which does not require the use of antacids and anti-secretory agents...
  61. ncbi Overexpression of heat shock protein 70 in stomach of stress-induced gastric ulcer-resistant rats
    Kazuko Shichijo
    Department of Molecular Pathology and Radiation Biophysics, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Department of Pathology, Nagasaki Medical Center, Japan
    Dig Dis Sci 48:340-8. 2003
    ..Our results indicate that overexpression of heat shock protein 70 in the stomach seems to protect against gastric ulcers through its cytoprotective effects on gastric mucosa by increasing mucosal blood flow...
  62. ncbi Clinical trial: rebamipide promotes gastric ulcer healing by proton pump inhibitor after endoscopic submucosal dissection--a randomized controlled study
    Tomohiro Kato
    Department of Gastroenterology, Gifu University Hospital, Gifu, Japan
    J Gastroenterol 45:285-90. 2010
    ..We examined the efficacy of a combination therapy of PPI and rebamipide, a mucosal-protective antiulcer drug, on the acceleration of post-ESD ulcer healing...
  63. pmc Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish adults
    S Rosenstock
    Copenhagen County Centre for Preventive Medicine, Glostrup University Hospital, Building 8 7 Nordre Ringvej, DK 2600 Glostrup, Denmark
    Gut 52:186-93. 2003
    ..No population based prospective cohort study has previously assessed the impact of multiple risk factors, including Helicobacter pylori infection, on the incidence of peptic ulcer disease (PUD)...
  64. ncbi Antioxidant activity of indigo and its preventive effect against ethanol-induced DNA damage in rat gastric mucosa
    Elisangela Farias-Silva
    Departamento de Fisiologia e Biofisica, IB, UNICAMP, Campinas, SP, Brazil
    Planta Med 73:1241-6. 2007
    ....
  65. ncbi Cannabinoids in acute gastric damage and pancreatitis
    A Dembinski
    Department of Physiology, Jagiellonian University Medical College, Krakow, Poland
    J Physiol Pharmacol 57:137-54. 2006
    ..The aim of the present study was to check whether the administration of CB1 receptor agonist or antagonist affects the stress-induced gastric ulceration and development of edematous pancreatitis...
  66. ncbi Rebamipide reduces delay in gastric ulcer healing in cyclooxygenase-2-deficient mice
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Dig Dis Sci 50:S63-9. 2005
    ..In conclusion, rebamipide may accelerate gastric ulcer healing through both COX-2-dependent and COX-2-independent mechanisms...
  67. ncbi Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn
    Poonam Dharmani
    Division of Pharmacology, Central Drug Research Institute, P O Box 173, Lucknow 226001, UP, India
    J Ethnopharmacol 93:197-206. 2004
    ..Conclusively, OS was found to possess potent anti-ulcerogenic as well as ulcer-healing properties and could act as a potent therapeutic agent against peptic ulcer disease...
  68. ncbi Effect of probiotics on aspirin-induced gastric mucosal lesions
    Altug Senol
    Department of Gastroenterology, Suleyman Demirel University, School of Medicine, Isparta
    Turk J Gastroenterol 22:18-26. 2011
    ..We aimed to investigate the role of a probiotic mixture, including 13 different bacteria, in the prevention of aspirin-induced gastric mucosal injury...
  69. ncbi Non-invasive analysis of reactive oxygen species generated in rats with water immersion restraint-induced gastric lesions using in vivo electron spin resonance spectroscopy
    Keiji Yasukawa
    Department of Bio function Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Free Radic Res 38:147-55. 2004
    ....
  70. ncbi The prevalence and distribution of gastric ulceration in 345 racehorses
    L M Begg
    Randwick Equine Centre, 3 Jane Street, Randwick, New South Wales 2031
    Aust Vet J 81:199-201. 2003
    ..To report the prevalence and distribution of gastric ulceration within a group of racehorses and to describe the endoscopic appearance of gastric antrum and pyloric ulceration...
  71. ncbi Protective effects of Punica granatum in experimentally-induced gastric ulcers
    Mohd Sarfaraz Alam
    Department of Ilmul Advia, Faculty of Medicine, Jamia Hamdard, New Delhi 110062, India
    Toxicol Mech Methods 20:572-8. 2010
    ..It prevents the ulceration by increasing the pH and mucus secretion in pylorus ligated rats. The present study shows the anti-ulcer activity of AMP in experimentally-induced gastric ulcers...
  72. ncbi The effect of a pectin-lecithin complex on prevention of gastric mucosal lesions induced by feed deprivation in ponies
    M J Murray
    Marion duPont Scott Equine Medical Center, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Leesburg 20177, USA
    Equine Vet J 34:195-8. 2002
    ..In this study, the pectin-lecithin complex in Pronutrin failed to prevent lesions in the gastric squamous mucosa induced by intermittent feed deprivation...
  73. ncbi Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats
    Y Raji
    Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Niger J Physiol Sci 26:43-8. 2011
    ..05) in extract treated rats when compared with the control. The results suggest that Ficus asperifolia possesses gastro-protective and antioxidant properties against gastric ulcer induced by indomethacin...
  74. ncbi A comparison of two scoring systems for endoscopic grading of gastric ulceration in horses
    R J W Bell
    Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    N Z Vet J 55:19-22. 2007
    ..To compare two scoring systems for grading gastric ulcers in adult horses...
  75. ncbi Are gastroprotective drugs useful for gastric ulcer healing: re-evaluation using current ICH E9 guidelines
    K Higuchi
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka, 545 8585, Japan
    Inflammopharmacology 15:18-21. 2007
    ..In conclusion, the superiority of cetraxate over placebo and non-inferiority to cetraxate for 7 drugs was established in the respect of effect on ulcer healing...
  76. ncbi Nonsteroidal anti-inflammatory drug-activated gene-1 plays a role in the impairing effects of cyclooxygenase inhibitors on gastric ulcer healing
    Rocchina Colucci
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    J Pharmacol Exp Ther 342:140-9. 2012
    ....
  77. ncbi Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds
    Guy D Lester
    School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, Western Australia
    J Am Vet Med Assoc 227:1636-9. 2005
    ..To compare the effects of oral administration of omeprazole and ranitidine on gastric squamous ulceration in Thoroughbreds in race training...
  78. ncbi Prevalence of gastric ulceration in Swedish Standardbreds in race training
    H Jonsson
    ATG s Hästsjukhus Färjestad, Norra Infarten 82, SE 654 65 Karlstad, Sweden
    Equine Vet J 38:209-13. 2006
    ..g. age, sex, performance, temperament and feeding regimens, need further elucidation...
  79. ncbi The results of Helicobacter pylori eradication on repeated bleeding in patients with stomach ulcer
    Darko Horvat
    Department of Internal Medicine, University Hospital Osijek, Osijek, Croatia
    Coll Antropol 29:139-42. 2005
    The triple therapy of Helicobacter pylori eradication prevents repeated bleeding from stomach ulcer. The aim of this one-way blind prospective study was to evaluate the efficiency of the two-week triple therapy for Helicobacter pylori ..
  80. ncbi Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing
    M Takahashi
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
    Biochem Biophys Res Commun 234:493-8. 1997
    ..We further demonstrate the expression of VEGF by cultured human gastric fibroblasts which is enhanced by tumor necrosis factor-alpha. These data suggest that VEGF may play a role in angiogenesis in the process of gastric ulcer healing...
  81. ncbi Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers
    Vaibhav Mishra
    Division of Pharmacology, CSIR Central Drug Research Institute, Lucknow, UP, India
    Phytomedicine 20:506-11. 2013
    ..75% respectively. Further, chebulinic acid significantly inhibited H(+) K(+)-ATPase activity in vitro with IC50 of 65.01 μg/ml as compared to the IC50 value of omeprazole (30.24 μg/ml) confirming its anti-secretory activity...
  82. ncbi Treatment and prevention of equine gastric ulcer syndrome
    Benjamin R Buchanan
    Department of Large Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville 37996, USA
    Vet Clin North Am Equine Pract 19:575-97. 2003
    ..Also, EGUS occurs in critically ill neonatal foals, but the pathogenesis may be different than in adult horses and acid-suppressive therapy may not be as effective...
  83. pmc Analysis of 3'-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population
    Leila Shokrzadeh
    Research Center of Gastroenterology and Liver Diseases, Shahid Beheshti University, MC, Tehran, Iran
    J Gastroenterol Hepatol 25:172-7. 2010
    ..pylori-related gastroduodenal pathogenesis. The aim was to determine the roles of EPIYA segments in gastroduodenal pathogenesis in an Iranian population...
  84. ncbi Design and synthesis of some substituted 1H-pyrazolyl-oxazolidines or 1H-pyrazolyl-thiazolidines as anti-inflammatory-antimicrobial agents
    Adnan A Bekhit
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
    Arch Pharm (Weinheim) 336:111-8. 2003
    ....
  85. ncbi Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat
    Peter C Konturek
    First Department of Medicine, University Erlangen Nuernberg, Erlangen, Germany
    Eur J Pharmacol 472:213-20. 2003
    ....
  86. ncbi Effects of hydrochloric, valeric, and other volatile fatty acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses
    Jenifer A Nadeau
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Am J Vet Res 64:413-7. 2003
    ..To identify in vitro effects of hydrochloric acid, valeric acid, and other volatile fatty acids (VFAs) on the pathogenesis of ulcers in the nonglandular portion of the equine stomach...
  87. ncbi Synergistic and potentiating effects of ranitidine and two new anti-ulcer compounds from Enantia chlorantha and Voacanga africana in experimental animal models
    P V Tan
    Department of Animal Biology and Physiology, University of Yaounde I, Cameroon
    Pharmazie 57:409-12. 2002
    ..A combination of TN and ranitidine led to synergistic antisecretory effects...
  88. ncbi Nutrition and dietary management of equine gastric ulcer syndrome
    Rilla E Reese
    Department of Animal Sciences and Large Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, Knoxville, TN, USA
    Vet Clin North Am Equine Pract 25:79-92, vi-vii. 2009
    ..In addition, a secondary goal is to provide information on how diet and environmental management can reduce ulcer severity and prevent recurrence in horses with EGUS...
  89. ncbi The prevalence and anatomical distribution of equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark
    N Luthersson
    Hestedoktoren I S, 4360 Kr Eskilstrup, Denmark
    Equine Vet J 41:619-24. 2009
    ..However, there have been few reports to confirm these findings in nonracehorses in Europe...
  90. ncbi Eradication of Helicobacter pylori improves the healing rate and reduces the relapse rate of nonbleeding ulcers in patients with bleeding peptic ulcer
    Perttu E T Arkkila
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Am J Gastroenterol 98:2149-56. 2003
    ..pylori) and peptic ulcer complications remains obscure. The aim of this study was to determine the importance of H. pylori and other risk factors for healing rate, ulcer recurrence, and rebleeding in patients with bleeding peptic ulcer...
  91. ncbi Effect of fungal colonization of gastric mucosa on the course of gastric ulcers healing
    M Zwolińska-Wcisło
    Department of Gastroenterology of Collegium Medicum, Jagiellonian University, ul Sniadeckich 10, Cracow, Poland
    Med Sci Monit 7:266-75. 2001
    ..The aim of the study was to evaluate the effect of fungal colonization on the course of gastric ulcer disease with particular regard to regression of clinical symptoms and reduction in ulcer niche size...
  92. pmc Antioxidant and gastric cytoprotective prostaglandins properties of Cassia sieberiana roots bark extract as an anti-ulcerogenic agent
    Edmund T Nartey
    Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, P, O, Box GP 4236, Accra, Ghana
    BMC Complement Altern Med 12:65. 2012
    ....
  93. ncbi The gender difference of selective serotonin reuptake inhibitor, fluoxetine in adult rats with stress-induced gastric ulcer
    Khaled A Abdel-Sater
    Rabigh Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Al Azher Faculty of Medicine, Assiut, Egypt
    Eur J Pharmacol 688:42-8. 2012
    ..Stressed male rats were more responsive to the antiulcer effect of fluoxetine more than stressed females. However, fluoxetine might be considered to be the first-choice drug in depressive patients with gastric ulcers in the future...
  94. ncbi Impact of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on gastric ulcerogenesis in experimental animals and in humans
    Teresa Pawlik
    Department of Physiology, University Medical College, Ul Grzegorzecka St 16, 31 531, Cracow, Poland
    Eur J Pharmacol 449:1-15. 2002
    ..pylori and NSAID are independent risk factors for peptic ulceration, and (3) NSAID therapy in H. pylori positive patients attenuates the ulcer development possibly due to direct inhibitory action of these drugs on H. pylori...
  95. ncbi Antiulcerogenic action of ethanolic extract of the resin from Virola surinamensis Warb. (Myristicaceae)
    Clelia Akiko Hiruma-Lima
    Physiology Department, Biosciences Institute, Sao Paulo State University UNESP, c p 510, 18618 000, Botucatu, SP, Brazil
    J Ethnopharmacol 122:406-9. 2009
    ..The resin obtained by cuts on the stem bark is a reputed folk remedy in its natural form for the treatment of ulcer, gastritis, inflammation and cancer...
  96. ncbi Endoscopy after Roux-en-Y gastric bypass: a community hospital experience
    Benjamin J Marano
    Department of Internal Medicine, Section of Gastroenterology, White Plains Hospital Center, White Plains, NY, USA
    Obes Surg 15:342-5. 2005
    ..Roux-en-Y gastric bypass (RYGBP) is a common surgical intervention for morbid obesity. Postoperative GI symptoms are common. This study reports the endoscopic findings in symptomatic patients...
  97. ncbi Effect of garlic oil on ethanol induced gastric ulcers in rats
    P Khosla
    Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Phytother Res 18:87-91. 2004
    ..The result suggests that garlic oil possesses antioxidant properties and provides protection against ethanol induced gastric injury...
  98. ncbi Healing of NSAID-induced gastric ulcers with a synthetic prostaglandin analog (enprostil)
    S J Sontag
    Department of Ambulatory Care, Veterans Administration Hospital, Hines, Illinois
    Am J Gastroenterol 89:1014-20. 1994
    ..Our objective in this study was to determine whether a prostaglandin analog is an effective treatment for such NSAID-induced lesions...
  99. pmc Detection of Helicobacter spp. in gastric, fecal and saliva samples from swine affected by gastric ulceration
    Patrizia Casagrande Proietti
    Department of Biopathological Science and Hygiene of Food and Animal Production, Faculty of Veterinary Medicine University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
    J Vet Sci 11:221-5. 2010
    ..With regard to feces and saliva samples, 15/25 (60%) and 16/25 (64%) were positive for Helicobacter spp. PCR, respectively but all were negative in H. suis and H. pylori specific PCR...
  100. ncbi Role of circadian rhythm and endogenous melatonin in pathogenesis of acute gastric bleeding erosions induced by stress
    T Brzozowski
    Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow, Poland
    J Physiol Pharmacol 58:53-64. 2007
    ....
  101. ncbi Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors
    Smriti Khanna
    Department of Chemistry, Discovery Research, Dr Reddy s Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India
    Bioorg Med Chem 14:4820-33. 2006
    ....

Research Grants32

  1. Immune Evasion by H. pylori
    Victor E Reyes; Fiscal Year: 2010
    ..pylori is a common human pathogen and infection with this bacterium causes gastritis and may lead to stomach ulcer and cancer. The objective of these studies is to define how H...
  2. Assessment of Infant Outcomes After in Utero Exposure to Antiretroviral Therapy
    Sonia Hernandez diaz; Fiscal Year: 2010
    ..We propose to evaluate the risk of congenital malformations and other adverse pregnancy outcomes following antenatal exposure to ART in a prospective cohort of pregnant women. ..
  3. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  4. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  5. NCRR Training Grant for Veterinary Students in Research
    Michael Davis; Fiscal Year: 2006
    ..Over a three-year period this program will contribute nine comparative medical scientists with veterinary medical degrees who are well trained in animal-oriented, hypothesis-based research. [unreadable] [unreadable]..
  6. Regulation of Fungal Invasive Growth
    Carol Kumamoto; Fiscal Year: 2006
    ..cerevisiae. Experiments are proposed to identify interactors that bind to the gene products of interest and to elucidate the pathways in which these gene products participate. ..
  7. STUDY OF OSTEOPOROTIC FRACTURES
    Marc Hochberg; Fiscal Year: 2005
    ....
  8. Inhibition of pathogen-induced NFkBmediated inflammation
    Richard Peek; Fiscal Year: 2005
    ..2)To identify and functionally characterize PPAR( target genes and microbially-induced NF-?B-regulated genes that are suppressed by PPAR(, activation using an in vitro model of intestinal epithelial cell inflammation. ..
  9. The ADEPT Study: Estimating Prognosis in Advanced Dementia
    Susan Mitchell; Fiscal Year: 2009
    ..Thus, the information derived from this study has the potential to make important clinical, research and policy-relevant contributions to the care of older persons with dementia at the end-of-life. ..
  10. The CASCADE Study: End-of-Life in Advanced Dementia
    Susan Mitchell; Fiscal Year: 2008
    ..abstract_text> ..
  11. Veterinary Comparative Respiratory Society 2008 Symposium
    Michael Davis; Fiscal Year: 2008
    ..This symposium will review the current knowledge and practical challenges of these models in order to make them more accessible to the biomedical research community. [unreadable] [unreadable] [unreadable]..
  12. Serum Organochlorine Levels and Primary Liver Cancer: A Nested Case-Control Study
    Lawrence Engel; Fiscal Year: 2009
    ....
  13. Intestinal colonization by C.albicans and enteric bacteria
    Carol Kumamoto; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  14. Neurogastric electrical stimulation for treating chemotherapy-induced emesis
    Jiande Chen; Fiscal Year: 2008
    ..Preliminary data supports this novel concept and experiments are designed to test the feasibility of the proposed method. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  15. Dual Pulse Electrical Stimulation for Gastroparesis
    Jiande Chen; Fiscal Year: 2007
    ..A number of innovative ideas are incorporated into the proposed method to tackle abnormalities related to gastroparesis. [unreadable] [unreadable] [unreadable]..
  16. 12th Biennial Meeting of the American Motility Society
    Jiande Chen; Fiscal Year: 2002
    ..Other factors such as financial hardship and minority issues will also be considered. We plan to issue 15 Young Investigator Awards and 10 Travel Awards. ..
  17. THERAPEUTIC POTENTIAL OF INTESTINAL PACING FOR OBESITY
    Jiande Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. ANIMAL MODELS OF COLD AIR-INDUCED AIRWAY DISEASE
    Michael Davis; Fiscal Year: 2004
    ..The investigators will use these same measurements to determine the changes in pulmonary mechanics and airway inflammation in dogs that perform repeated exercise in frigid environments. ..
  19. PHOSPHOLIPIDS AND ULCER PROTECTION
    Lenard Lichtenberger; Fiscal Year: 2002
    ....
  20. Regulation of Drug Resistance Genes in C. Albicans
    Carol Kumamoto; Fiscal Year: 2007
    ..The long-term goal of these studies is to contribute to a more informed use of fluconazole with respect to prophylaxis, drug dosage regimens and the development of fluconazole resistant strains. [unreadable] [unreadable] [unreadable]..
  21. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..heme uptake pathways will have a great impact in understanding disorders associated with iron overload (hereditary hemochromatosis, iron overload secondary to blood transfusions) and nutritional iron deficiency [unreadable] [unreadable]..
  22. Dual-pulse electrical stimulation for gastroparesis
    Jiande Chen; Fiscal Year: 2004
    ..Once the efficacy of the proposed method is proven, an implantable stimulator will be developed and its long-term efficacy for the treatment of gastroparesis will be evaluated in a Phase II project. ..
  23. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  24. Intestinal Pacing for Intestinal Pseudo-Obstruction
    Jiande Chen; Fiscal Year: 2007
    ..Feasibility of such a novel method will be tested in this Phase I project. [unreadable] [unreadable] [unreadable]..
  25. Role of T Cells in Lung Disease in Systemic Sclerosis
    Marc Hochberg; Fiscal Year: 2006
    ..The new information that is gained will advance knowledge of T-cell dependent mechanisms of pulmonary fibrosis in scleroderma. ..
  26. Mechanism that regulate Helicobacter pylori-induced beta-caterin activation
    Richard Peek; Fiscal Year: 2009
    ..py/ori-induced B-catenin activation. 3. To define differences in epithelial molecular responses to carcinogenic H. pylori versus mutant strains using a transgenic murine model of gastric cancer. ..
  27. Tube-feeding in Elderly: Decision-making and Outcomes
    Susan Mitchell; Fiscal Year: 2003
    ..By the end of the award period the applicant will have the skills, experience and research track record necessary to become an independent investigator and leader in academic geriatrics. ..
  28. Geriatric Depression Outcomes: Prognostic Factors
    Warren Taylor; Fiscal Year: 2007
    ..Discussion: These findings will better describe the role of neural connectivity and striatofrontal dysfunction in geriatric depression. ..
  29. Vascular Depression: Longitudinal Changes
    Warren D Taylor; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  30. Clinical Studies with Phospholipid-Associated NSAIDs
    Lenard Lichtenberger; Fiscal Year: 2004
    ..i.d.) with diclofenac-PC, except in this case we will add a third arm of the study in which the subjects are administered the COX- inhibitor, Celecoxib, at a dose (200 mg b.i.d.) having equivalent therapeutic efficacy to diclofenac. ..
  31. Inhibitors to Clostridium perfrigens epsilon toxin
    MARK MCCLAIN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..