peptic ulcer perforation

Summary

Summary: Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.

Top Publications

  1. ncbi The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events
    Richard H Hunt
    Division of Gastroenterology, McMaster University Medical Center, Hamilton, Ontario, Canada
    Am J Gastroenterol 98:1725-33. 2003
  2. ncbi Laparoscopic and open approach in perforated peptic ulcer
    Hiroaki Tsumura
    Department of Surgery, Hiroshima Municipal Funairi Hospital, Hiroshima University School of Medicine, Hiroshima, Japan
    Hepatogastroenterology 51:1536-9. 2004
  3. ncbi Perforated peptic ulcer in children: a 20-year experience
    Man Chin Hua
    Division of Pediatric Critical Care and Emergency Medicine, Chang Gung Children s Hospital, Taiwan
    J Pediatr Gastroenterol Nutr 45:71-4. 2007
  4. ncbi Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s
    S Hernandez-Diaz
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 160:2093-9. 2000
  5. pmc Trends in diagnosis and surgical management of patients with perforated peptic ulcer
    Kenneth Thorsen
    Division of Gastroenterologic Surgery, Department of Surgery, Stavanger University Hospital, 4068, Stavanger, Norway
    J Gastrointest Surg 15:1329-35. 2011
  6. pmc Randomized clinical trial of laparoscopic versus open repair of the perforated peptic ulcer: the LAMA Trial
    Marietta J O E Bertleff
    Department of Plastic and Reconstructive Surgery, Academic Hospital Maastricht, Maastricht, The Netherlands
    World J Surg 33:1368-73. 2009
  7. ncbi Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation
    M H Møller
    Department of Anaesthesiology and Intensive Care Medicine, Copenhagen University Hospital Herlev, Herlev, Denmark
    Br J Surg 98:802-10. 2011
  8. ncbi Diabetes and 30-day mortality from peptic ulcer bleeding and perforation: a Danish population-based cohort study
    Reimar W Thomsen
    Department of Clinical Epidemiology, Aarhus University Hospital, DK 9100 Aalborg, Denmark
    Diabetes Care 29:805-10. 2006
  9. ncbi A simplified prognostic scoring system for peptic ulcer perforation in developing countries
    Arpan Mishra
    G I Surgery Unit, Department of Surgery, NSCB Government Medical College, Jabalpur, Madhya Pradesh
    Indian J Gastroenterol 22:49-53. 2003
  10. ncbi The Peptic Ulcer Perforation (PULP) score: a predictor of mortality following peptic ulcer perforation. A cohort study
    M H Møller
    Department of Anaesthesiology and Intensive Care Medicine, Copenhagen University Hospital Bispebjerg, Denmark
    Acta Anaesthesiol Scand 56:655-62. 2012

Detail Information

Publications197 found, 100 shown here

  1. ncbi The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events
    Richard H Hunt
    Division of Gastroenterology, McMaster University Medical Center, Hamilton, Ontario, Canada
    Am J Gastroenterol 98:1725-33. 2003
    ....
  2. ncbi Laparoscopic and open approach in perforated peptic ulcer
    Hiroaki Tsumura
    Department of Surgery, Hiroshima Municipal Funairi Hospital, Hiroshima University School of Medicine, Hiroshima, Japan
    Hepatogastroenterology 51:1536-9. 2004
    ..To improve the perioperative course and quality of life of the patients with perforated peptic ulcer, we investigated the conversion risk factors in laparoscopic simple closure and omental patch repair for perforated peptic ulcer...
  3. ncbi Perforated peptic ulcer in children: a 20-year experience
    Man Chin Hua
    Division of Pediatric Critical Care and Emergency Medicine, Chang Gung Children s Hospital, Taiwan
    J Pediatr Gastroenterol Nutr 45:71-4. 2007
    ..Although the detection of pediatric peptic ulcer disease (PUD) has recently been increasing, perforated peptic ulcer (PPU) in children is rare. We report our experience with PPU in children...
  4. ncbi Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s
    S Hernandez-Diaz
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 160:2093-9. 2000
    ..Later analyses have also included the effect of patterns of NSAID use, risk factors for UGIB, and modifiers of NSAID effect...
  5. pmc Trends in diagnosis and surgical management of patients with perforated peptic ulcer
    Kenneth Thorsen
    Division of Gastroenterologic Surgery, Department of Surgery, Stavanger University Hospital, 4068, Stavanger, Norway
    J Gastrointest Surg 15:1329-35. 2011
    ..Only a few studies have evaluated its overall utility. The aim of this study was to investigate changes in surgical management of PPU and associated outcomes...
  6. pmc Randomized clinical trial of laparoscopic versus open repair of the perforated peptic ulcer: the LAMA Trial
    Marietta J O E Bertleff
    Department of Plastic and Reconstructive Surgery, Academic Hospital Maastricht, Maastricht, The Netherlands
    World J Surg 33:1368-73. 2009
    ..The goal of the present study was to evaluate whether laparoscopic closure of a PPU is as safe as conventional open correction...
  7. ncbi Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation
    M H Møller
    Department of Anaesthesiology and Intensive Care Medicine, Copenhagen University Hospital Herlev, Herlev, Denmark
    Br J Surg 98:802-10. 2011
    ..The aim of the present study was to evaluate the effect of a multimodal and multidisciplinary perioperative care protocol on mortality in patients with PPU...
  8. ncbi Diabetes and 30-day mortality from peptic ulcer bleeding and perforation: a Danish population-based cohort study
    Reimar W Thomsen
    Department of Clinical Epidemiology, Aarhus University Hospital, DK 9100 Aalborg, Denmark
    Diabetes Care 29:805-10. 2006
    ..We examined whether diabetes increased 30-day mortality among Danish patients hospitalized with bleeding or perforated peptic ulcers...
  9. ncbi A simplified prognostic scoring system for peptic ulcer perforation in developing countries
    Arpan Mishra
    G I Surgery Unit, Department of Surgery, NSCB Government Medical College, Jabalpur, Madhya Pradesh
    Indian J Gastroenterol 22:49-53. 2003
    ..Several complex prognostic scoring systems are available for abdominal sepsis. We constructed and assessed a simplified scoring system for peptic perforation, which can be easily used in developing countries...
  10. ncbi The Peptic Ulcer Perforation (PULP) score: a predictor of mortality following peptic ulcer perforation. A cohort study
    M H Møller
    Department of Anaesthesiology and Intensive Care Medicine, Copenhagen University Hospital Bispebjerg, Denmark
    Acta Anaesthesiol Scand 56:655-62. 2012
    ..The objective of the present study was to develop a new and improved clinical rule to predict mortality in patients following surgical treatment for PPU...
  11. ncbi Accuracy of clinical prediction rules in peptic ulcer perforation: an observational study
    David Levarett Buck
    Emergency Department, Holbæk Hospital, Denmark
    Scand J Gastroenterol 47:28-35. 2012
    ....
  12. ncbi Complications of peptic ulcer disease
    Tomica Milosavljevic
    Clinical Center of Serbia, Gastroenterology and Hepatology Clinic, University of Belgrade, Faculty of Medicine, Belgrade, Serbia
    Dig Dis 29:491-3. 2011
    ..Transcatheter arterial embolization is also an effective and safe treatment in patients with duodenal ulcers re-bleeding after therapeutic endoscopy or surgery...
  13. ncbi Preoperative prognostic factors for mortality in peptic ulcer perforation: a systematic review
    Morten Hylander Møller
    Department of Anaesthesiology and Intensive Care Medicine, Copenhagen University Hospital Herlev, Denmark
    Scand J Gastroenterol 45:785-805. 2010
    ..During the last three decades a large number of preoperative prognostic factors in patients with PPU have been examined. The aim of this systematic review was to summarize available evidence on these prognostic factors...
  14. ncbi Duration of survival after peptic ulcer perforation
    Michael Imhof
    Department of General and Trauma Surgery, Malteser Hospital St Hildegardis, Bachemer Str 29 33, 50931 Cologne, Germany
    World J Surg 32:408-12. 2008
    The long-term course after peptic ulcer perforation is unclear, but because the ulcer population is generally older and has concomitant disease, the long-term prognosis may be expected to be poor.
  15. ncbi Systematic review and meta-analysis: Helicobacter pylori eradication therapy after simple closure of perforated duodenal ulcer
    Prakitpunthu Tomtitchong
    Department of Surgery, Faculty of Medicine, Thammasat University, Pathumthani, Thailand
    Helicobacter 17:148-52. 2012
    ..The most common complications of peptic ulcer are bleeding and perforation. In many regions, definitive acid reduction surgery has given way to simple closure and Helicobacter pylori eradication...
  16. pmc Laparoscopic correction of perforated peptic ulcer: first choice? A review of literature
    Marietta J O E Bertleff
    Department of Plastic and Reconstructive Surgery, Academic Hospital Maastricht, P Debeyelaan 25, 6229 HX, Maastricht, The Netherlands
    Surg Endosc 24:1231-9. 2010
    ....
  17. ncbi Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs
    A S Taha
    Department of Gastroenterology, Crosshouse Hospital, Kilmarnock, Scotland, UK
    Aliment Pharmacol Ther 28:878-85. 2008
    It is not clear whether the incidence or early mortality related to peptic ulcer perforation has changed.
  18. ncbi Laparoscopic surgery for common surgical emergencies: a population-based study
    C M Lam
    Central Surgical Audit Unit, Central Coordinating Committee of Surgery, Hospital Authority, Hospital Authority Building, 147B Argyle Street, Kowloon, Hong Kong
    Surg Endosc 19:774-9. 2005
    ....
  19. ncbi Perforated peptic ulcer disease: a review of history and treatment
    Marietta J O E Bertleff
    Department of Plastic and Reconstructive Surgery, Academic Hospital Maastricht, Maastricht, The Netherlands
    Dig Surg 27:161-9. 2010
    ....
  20. ncbi Factors influencing mortality in perforated duodenal ulcer following emergency surgical repair
    S K Subedi
    BP Koirala Institute of Health Sciences, Dharan, Nepal
    JNMA J Nepal Med Assoc 46:31-5. 2007
    ....
  21. ncbi Management of perforated peptic ulcer in patients at a teaching hospital
    Ali K Bin-Taleb
    Department of Surgery, Faculty of Medicine and Health Sciences, University of Aden, Aden, Yemen
    Saudi Med J 29:245-50. 2008
    ..To explore and analyze the current status in management of patients with perforated peptic ulcers (PPU)...
  22. ncbi Comparison and validation of scoring systems in a cohort of patients treated for perforated peptic ulcer
    Mahmut Koc
    Fifth Department of Surgery, Ankara Numune Education and Research Hospital, 5 Cad 10 3, 06500, Ankara, Turkey
    Langenbecks Arch Surg 392:581-5. 2007
    ..The aim of this study is to evaluate the predictive accuracy of different scoring systems on surgery for perforated peptic ulcer referred to an academic department of general surgery in a tertiary reference center...
  23. ncbi [Perforated peptic ulcer--a 12-year material]
    Håvard Mjørud Forsmo
    Kirurgisk avdeling, Sykehuset Innlandet Gjøvik, 2819 Gjøvik
    Tidsskr Nor Laegeforen 125:1822-4. 2005
    ..We aimed to explore patient characteristics, diagnostic and surgical procedures and results of treatment of perforated peptic ulcer at our hospital, and determine prognostic factors for death and postoperative complications...
  24. ncbi Morbidity and mortality of perforated peptic gastroduodenal ulcer following emergency surgery
    P Kujath
    Department of Surgery, Medical University of Lubeck, Germany
    Langenbecks Arch Surg 387:298-302. 2002
    ..This study assessed the surgical concept and prognosis of perforated gastroduodenal ulcers...
  25. pmc Incidence and short-term mortality from perforated peptic ulcer in Korea: a population-based study
    SeungJin Bae
    Health Insurance Review and Assessment Service, Research and Development Center, Seoul, South Korea
    J Epidemiol 22:508-16. 2012
    ..We estimated age- and sex-specific incidence and short-term mortality from PPU among Koreans and investigated the risk factors for mortality associated with PPU development...
  26. ncbi Results of surgery for perforated gastroduodenal ulcers in a Dutch population
    P H J Hemmer
    Department of Surgery, Leeuwarden Medical Center, Leeuwarden, The Netherlands
    Dig Surg 28:360-6. 2011
    ..This study was designed to evaluate the results of surgery for perforated ulcer disease and to identify prognostic factors for mortality in order to optimize treatment...
  27. ncbi Impact of preoperative physiological risk profile on postoperative morbidity and mortality after emergency operation of complicated peptic ulcer disease
    Jan Hendrik Egberts
    Department of General Surgery and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    World J Surg 31:1449-57. 2007
    ..The aim of this study was to evaluate the preoperative physiological risk profile for postoperative morbidity and mortality after emergency treatment of complicated peptic ulcer disease (PUD)...
  28. ncbi Factors associated with postoperative complications and mortality in perforated peptic ulcer
    Eduardo Esteban Montalvo-Javé
    Facultad de Medicina, Universidad Nacional Autonoma de Mexico UNAM, Mexico
    Cir Cir 79:141-8. 2011
    ..The aim of this study was to identify factors associated with early postoperative complications and mortality of patients admitted to the emergency department with perforated peptic ulcer...
  29. ncbi Mortality in perforated duodenal ulcer depends upon pre-operative risk: a retrospective 10-year study
    J O Larkin
    Department of Surgery, Mayo General Hospital, Castlebar, CO, Mayo, Ireland
    Ir J Med Sci 179:545-9. 2010
    ..We retrospectively reviewed our experience with operative and conservative management of perforated duodenal ulcers over a 10-year period and analysed outcome according to American Society of Anesthesiologists (ASA) score...
  30. ncbi Perforated peptic ulcer disease: mid-term outcome among Iranian population
    Freshteh Kamani
    Department of Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Turk J Gastroenterol 21:125-8. 2010
    ..The aim of this study was to evaluate midterm outcome of patients with perforated peptic ulcer disease and to determine the main predictors of mid-term mortality...
  31. ncbi Candida peritonitis due to peptic ulcer perforation: incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B
    Sai Cheong Lee
    Division of Infectious Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan
    Diagn Microbiol Infect Dis 44:23-7. 2002
    Sixty-two cases of peritonitis due to peptic ulcer perforation were diagnosed between January 2000 and December 2000. Of these 62 cases, 23 isolates of Candida in 23 cases (CP) were cultured from peritoneal fluid...
  32. ncbi Antipsychotic drugs and short-term mortality after peptic ulcer perforation: a population-based cohort study
    C Christiansen
    Department of Clinical Epidemiology, Aarhus University Hospital, University of Aarhus, Aarhus, Dennmark
    Aliment Pharmacol Ther 28:895-902. 2008
    b>Peptic ulcer perforation is a serious surgical emergency with a substantial short-term mortality, but the influence of antipsychotic drug use on the prognosis remains unknown.
  33. ncbi Community-based evaluation of laparoscopic versus open simple closure of perforated peptic ulcers
    Kazuaki Kuwabara
    Department of Health Care Administration and Management, Kyushu University, Graduate School of Medical Sciences, 3 1 1 Maidashi Higashi ku, Fukuoka, 812 8582, Japan
    World J Surg 35:2485-92. 2011
    ..However, there has been no comprehensive community-based evaluation of the advantages of using LSC over open simple closure (OSC). Using an administrative database, we evaluated LSC versus OSC for patients with perforated ulcers...
  34. ncbi Prognostic factors of peptic ulcer perforation
    Ibrahim Barut
    Department of Surgery, School of Medicine, Suleyman Demirel University, Isparta, Turkey
    Saudi Med J 26:1255-9. 2005
    ..However, emergency surgery for perforated ulcer presently carries a mortality risk of up to 30%. The aim of this study is to analyze and define factors influencing surgical prognosis in patients operated upon for PPU...
  35. pmc Perforated duodenal ulcer presenting with massive hematochezia in a 30-month-old child
    Na Mi Lee
    Department of Pediatrics, College of Medicine, Chung Ang University, Dongjak Gu, Seoul, South Korea
    World J Gastroenterol 15:4853-5. 2009
    ..Finally, an exploratory laparotomy was performed. A discrete anterior perforation with active bleeding of the duodenal wall was found. After the operation, there were no complications and the patient recovered fully...
  36. ncbi Gastro-duodenal peptic ulcer perforation
    J C B Dakubo
    University of Ghana, Medical School, P O Box 4236, Accra, Ghana
    East Afr Med J 86:100-9. 2009
    ..To determine the epidemiology of, and define the morbidity and mortality factors following emergency surgery for patients with perforated peptic ulcer disease in Accra, Ghana...
  37. ncbi Peptic ulcer perforation: management of high-risk cases by percutaneous abdominal drainage
    M Mizanur Rahman
    Department of Surgery, Khulna Medical College, Khulna 9000, Bangladesh
    Trop Doct 35:30-1. 2005
    ..There were three (4.5%) deaths; 58 (87.8%) patients improved satisfactorily. High-risk peptic ulcer perforation patients can be managed by putting in an intra-abdominal drain supported by conservative treatment.
  38. ncbi Evaluation of risk factors for mortality in surgically treated perforated peptic ulcer
    T Sillakivi
    Department of Surgery, University of Tartu, Puusepa 8, 51014 Tartu, Estonia
    Hepatogastroenterology 47:1765-8. 2000
    ..The aim of our study was to evaluate complications and possible risk factors for mortality in perforated peptic ulcer patients with a special reference to the fact whether definitive or non-definitive operation was performed...
  39. ncbi Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico, Universidad de Zaragoza, Zaragoza, Spain
    Am J Gastroenterol 104:1633-41. 2009
    ....
  40. ncbi Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population
    Luis A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Gastroenterology 132:498-506. 2007
    ..Whether use of selective inhibitors of cyclooxygenase-2 (COXIBs) will translate into a clinically relevant reduced toxicity has not been widely investigated in the general population...
  41. ncbi Accuracy of MDCT in predicting site of gastrointestinal tract perforation
    Bernard Hainaux
    Department of Radiology, Centre Hospitalier Universitaire St Pierre, Universite Libre de Bruxelles, 322 rue Haute, Brussels 1000, Belgium
    AJR Am J Roentgenol 187:1179-83. 2006
    ....
  42. ncbi A randomized trial of nonoperative treatment for perforated peptic ulcer
    T J Crofts
    Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    N Engl J Med 320:970-3. 1989
    ....
  43. pmc Eradication of Helicobacter pylori prevents recurrence of ulcer after simple closure of duodenal ulcer perforation: randomized controlled trial
    E K Ng
    Department of Surgery, The Chinese University of Hong Kong, Hong Kong
    Ann Surg 231:153-8. 2000
    ..In this randomized trial, the authors sought to determine whether eradication of Helicobacter pylori could reduce the risk of ulcer recurrence after simple closure of perforated duodenal ulcer...
  44. ncbi Factors affecting mortality and morbidity in patients with peptic ulcer perforation
    Belma Kocer
    Ankara Numune Training and Research Hospital, Second General Surgery Clinic, Ankara, Turkey
    J Gastroenterol Hepatol 22:565-70. 2007
    ..The purpose of this study was to identify the risk factors that predict morbidity and mortality in patients with perforated PU...
  45. ncbi Perforated peptic ulcer: clinical presentation, surgical outcomes, and the accuracy of the Boey scoring system in predicting postoperative morbidity and mortality
    Varut Lohsiriwat
    Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Prannok Road, Bangkok, 10700, Thailand
    World J Surg 33:80-5. 2009
    ..The purposes of this study were to determine clinical presentations and surgical outcomes of perforated peptic ulcer (PPU), and to evaluate the accuracy of the Boey scoring system in predicting mortality and morbidity...
  46. ncbi Significant factors associated with fatal outcome in emergency open surgery for perforated peptic ulcer
    Mario Testini
    Section of General Surgery and Vascular Surgery and Clinical Oncology, Department of Applications in Surgery of Innovative Technologies DACTI, University Medical School, Bari, Italy
    World J Gastroenterol 9:2338-40. 2003
    ..To evaluate the main factors associated with mortality in patients undergoing surgery for perforated peptic ulcer referred to an academic department of general surgery in a large southern Italian city...
  47. ncbi Perforated peptic ulcer: main factors of morbidity and mortality
    Carlos Noguiera
    Surgery Department, Surgery 1, Hospital Geral de Santo Antonio, Instituto de Ciencias Biomedicas Abel Salazar, Largo do Prof Abel Salazar, 4099 001 Oporto, Portugal
    World J Surg 27:782-7. 2003
    ..There was no statistically significant difference concerning morbidity and mortality between simple closure of the perforation and definitive surgery (VT + Dr)...
  48. ncbi Helicobacter pylori infection and perforated peptic ulcer prevalence of the infection and role of antimicrobial treatment
    Javier P Gisbert
    Department of Gastroenterology University Hospital of La Princesa, Madrid, Spain
    Helicobacter 8:159-67. 2003
    ..Recurrent ulcer disease after peptic ulcer perforation mainly occurs in patients with H...
  49. pmc Laparoscopic repair for perforated peptic ulcer: a randomized controlled trial
    Wing T Siu
    Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, SAR, China
    Ann Surg 235:313-9. 2002
    ..To compare the results of open versus laparoscopic repair for perforated peptic ulcers...
  50. ncbi Predicting mortality and morbidity of patients operated on for perforated peptic ulcers
    F Y Lee
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Arch Surg 136:90-4. 2001
    ..CONCLUSIONS: The APACHE II score may be a useful tool for stratifying patients into various risk groups, and the Boey score might select appropriate patients for laparoscopic repair...
  51. ncbi Gastro-duodenal perforations: conventional plain film, US and CT findings in 166 consecutive patients
    Roberto Grassi
    Department Magrassi Lanzara, Second University, 80138 Naples, Italy
    Eur J Radiol 50:30-6. 2004
    ..The aim of our study was to report our experience in the diagnosis of gastro-duodenal perforation by conventional radiography, US and CT examinations...
  52. ncbi Epidemiology of duodenal ulcer perforation: a study on hospital admissions in Norfolk, United Kingdom
    D S Canoy
    Department of Public Health and Primary Care, University of Cambridge, UK
    Dig Liver Dis 34:322-7. 2002
    ..To provide updated epidemiological data on duodenal ulcer perforation, the incidence of the disease in Norfolk, United Kingdom was determined...
  53. ncbi Surgical treatment of complicated duodenal ulcers: controlled trials
    B Millat
    , Rue Bertrand Sans, 34295 Montpellier, France
    World J Surg 24:299-306. 2000
    ..pylori; (2) surgery to endoscopic treatment combined with eradication of H. pylori; and (3) for GOO, surgery to balloon dilatation combined with eradication of H. pylori...
  54. ncbi 30-day mortality after peptic ulcer perforation among users of newer selective COX-2 inhibitors and traditional NSAIDs: a population-based study
    Reimar W Thomsen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
    Am J Gastroenterol 101:2704-10. 2006
    Nonsteroidal anti-inflammatory drug (NSAID) use is a strong risk factor for peptic ulcer perforation, yet little is known about the outcome of this condition among NSAID users...
  55. ncbi Risk factors in patients surgically treated for peptic ulcer perforation
    Morten Hylander Møller
    Department of Anaesthesiology and Intensive Care Medicine, Copenhagen University Hospital, Herlev, Denmark
    Scand J Gastroenterol 44:145-52, 2 p following 152. 2009
    ..The objective of this study was to identify and describe perioperative risk factors in order to identify ways of optimizing the treatment and to improve the outcome of patients with perforated peptic ulcer...
  56. ncbi Surgery for peptic ulcer today. A study on the incidence, methods and mortality in surgery for peptic ulcer in Finland between 1987 and 1999
    H Paimela
    Department of Surgery, Helsinki University Central Hospital, Jorvi Hospital, Espoo, Finland
    Dig Surg 21:185-91. 2004
    ..Simultaneously there has been a significant improvement in living and dietary habits. Quite presumably, all these significant events are reflected in the incidence and results of surgery for peptic ulcerations...
  57. ncbi Gastrointestinal tract perforation: CT diagnosis of presence, site, and cause
    A Furukawa
    Department of Radiology, Shiga University of Medical Science, Seta Tsukinowa cho Otsu, Shiga 520 2192, Japan
    Abdom Imaging 30:524-34. 2005
    ..Gastrointestinal mural pathology and associated adjacent inflammation are precisely assessed with thin-section images and multiplanar reformations that aid in the assessment of the site and cause of perforation...
  58. ncbi Perforated peptic ulcer
    P H Jordan
    Cora and Webb Mading Department of Surgery, Baylor College of Medicine, Houston, Texas
    Surg Clin North Am 68:315-29. 1988
    ..Patients who have significant risk factors should undergo simple closure. Closure of the ulcer with parietal cell vagotomy is the author's first choice for definitive operative treatment when this procedure can be performed...
  59. ncbi Mortality in perforated peptic ulcer patients after selective management of stratified poor risk cases
    M Mizanur Rahman
    Department of Surgery, National Institute of Cancer and Research, Mohakhali, Dhaka, Bangladesh
    World J Surg 31:2341-4; discussion 2345-6. 2007
    ..In this study we demonstrate a treatment option that improves the mortality among critically ill, poor risk patients with perforated peptic ulcer disease...
  60. ncbi Laparoscopic repair of perforated ulcer in Western Denmark - a retrospective study
    T Sommer
    Department of Surgery, Randers Hospital, Randers, Denmark
    Scand J Surg 99:119-21. 2010
    ..to report the distribution and results of laparoscopic repair of perforated ulcer surgery in surgical departments in a major region in Denmark and compare it with the results from the national database regarding mortality and morbidity...
  61. ncbi Perforated peptic ulcer: how to improve outcome?
    Morten Hylander Møller
    Department of Anaesthesiology and Intensive Care Medicine, Copenhagen University Hospital Herlev, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Scand J Gastroenterol 44:15-22. 2009
    ..emergency surgery for perforated peptic ulcer and the mortality rate for patients undergoing surgery for peptic ulcer perforation have increased. This increase has occurred despite improvements in perioperative treatment and monitoring...
  62. ncbi Use of a fibrinogen- and thrombin-coated patch for peptic ulcer perforation repair
    Isidoro Di Carlo
    Department of Surgical Sciences, Organ Transplantation and Advanced Technologies, University of Catania, Cannizzaro Hospital, Catania, Italy
    Hepatogastroenterology 56:575-7. 2009
    ..To present our experience with 2 patients treated with a fibrinogen- and thrombin-coated collagen patch to repair a perforated peptic ulcer...
  63. ncbi Risk factors influencing the early outcome results after laparoscopic repair of perforated duodenal ulcer and their predictive value
    Raimundas Lunevicius
    Clinic of General and Plastic Surgery, Orthopaedics and Traumatology, Vilnius University, Siltnamiu str 29, 04130, Vilnius, Lithuania
    Langenbecks Arch Surg 390:413-20. 2005
    ..The aims of our study are to report the early outcome results after operation and to define the predictive values of risk factors influencing conversion rate and genesis of suture leakage...
  64. pmc Decreasing incidence of peptic ulcer complications after the introduction of the proton pump inhibitors, a study of the Swedish population from 1974-2002
    Michael Hermansson
    Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
    BMC Gastroenterol 9:25. 2009
    ....
  65. ncbi Introduction of newer selective cyclo-oxygenase-2 inhibitors and rates of hospitalization with bleeding and perforated peptic ulcer
    S Christensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Aliment Pharmacol Ther 25:907-12. 2007
    ....
  66. ncbi Routine use of laparoscopic repair for perforated peptic ulcer
    W T Siu
    Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, China
    Br J Surg 91:481-4. 2004
    ..The aim of this study was to evaluate the safety and efficacy of laparoscopic repair for perforated peptic ulcer in routine clinical practice...
  67. ncbi Multimedia article: management of duodenal ulcer perforation with combined laparoscopic and endoscopic methods
    H A Alvarado-Aparicio
    Endoscopic Surgery Department, General Hospital Dr Manuel Gea Gonzalez, Calzada de Tlalpan 4800, colonia Toriella Guerra, Mexico, DF
    Surg Endosc 18:1394. 2004
    ....
  68. ncbi Management of complicated peptic ulcer disease
    Stephen W Behrman
    Department of Surgery, University of Tennessee Health Science Center Memphis, Memphis, TN 38163, USA
    Arch Surg 140:201-8. 2005
  69. ncbi CT evaluation of gastrointestinal tract perforation
    Kwok Wan Yeung
    Department of Radiology, Foo Yin University Hospital, 5, Chung San Road, Tung Kang, Ping Tung, 928 Taiwan, ROC
    Clin Imaging 28:329-33. 2004
    ..05). CT detected extraluminal air in more cases than the upright plain films did (69% vs. 19%; Z=4.62>Z(0.01)=2.326). We concluded that CT is a good imaging tool to differentiate the various GI perforations...
  70. ncbi Laparoscopic repair of perforated peptic ulcer with delayed presentation
    Beena B Vaidya
    Department of Surgery, Government Medical College and New Civil Hospital, Surat, India
    J Laparoendosc Adv Surg Tech A 19:153-6. 2009
    ..Laparoscopic repair has been used to treat perforated peptic ulcers since 1990 and is gaining acceptance. The main concerns are postoperative intra-abdominal collections and performing laparoscopy in the presence of peritonitis...
  71. ncbi Management strategies, early results, benefits, and risk factors of laparoscopic repair of perforated peptic ulcer
    Raimundas Lunevicius
    2nd Department of Abdominal Surgery, Clinic of General and Plastic Surgery, Orthopaedics, and Traumatology, Vilnius University Emergency Hospital, Vilnius University, Siltnamiu Street 29, LT 04130 Vilnius, Lithuania
    World J Surg 29:1299-310. 2005
    ..Inadequate ulcer localization, large perforation size (defined by some as > 6 mm diameter, and by others as > 10 mm), and ulcers with friable edges are also considered as conversion risk factors...
  72. ncbi Systematic review comparing laparoscopic and open repair for perforated peptic ulcer
    R Lunevicius
    Clinic of General and Plastic Surgery, Orthopaedics and Trauma Surgery, General Surgery Centre, Vilnius University Emergency Hospital, 29 Siltnamiu Street, LT 04130, Vilnius, Lithuania
    Br J Surg 92:1195-207. 2005
    ..The advantages of laparoscopic over open repair for perforated peptic ulcer are not as obvious as they may seem. This paper summarizes the published trials comparing the two approaches...
  73. pmc Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study
    Harald E Vonkeman
    Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente Hospital and University of Twente, Ariensplein 1, 7500 KA, Enschede, The Netherlands
    Arthritis Res Ther 9:R52. 2007
    ..17 to 0.67; p = 0.002). Especially at risk for NSAID ulcer complications are elderly patients with cardiovascular co-morbidity. Proton-pump inhibitors are associated with a reduced risk for NSAID ulcer complications...
  74. ncbi Gastric body partition for giant perforated peptic ulcer in critically ill elderly patients
    Jia Fwu Shyu
    Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, R O C
    World J Surg 30:2204-7; discussion 2208-9. 2006
    ....
  75. ncbi Laparoscopic management of duodenal ulcer perforation: is it advantageous?
    C Palanivelu
    Department of GI and Minimal Access Surgery, GEM Hospital, 45A, Pankaja Mill Road, Coimbatore, India
    Indian J Gastroenterol 26:64-6. 2007
    ..Surgery is the mainstay of treatment of patients with peptic duodenal perforation. With the advent of minimal access techniques, laparoscopy is being used for the treatment of this condition...
  76. ncbi Laparoscopic repair of peptic ulcer perforation without omental patch versus conventional open repair
    Mustafa Ates
    Department of General Surgery, Malatya State Hospital, Malatya, Turkey
    J Laparoendosc Adv Surg Tech A 17:615-9. 2007
    ....
  77. ncbi The "stamp method": a new treatment for perforated peptic ulcer?
    M J O E Bertleff
    Department of Plastic Surgery, Academic Hospital Groningen, Hanzeplein 1, P O Box 30001, Groningen, 9700 RB, The Netherlands
    Surg Endosc 20:791-3. 2006
    ..The aim of this study was to develop a simple method for closure of a perforated peptic ulcer, making it more accessible for laparoscopic surgery...
  78. ncbi Perforated peptic ulcer: use of pre-admission oral glucocorticoids and 30-day mortality
    S Christensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    Aliment Pharmacol Ther 23:45-52. 2006
    Despite evidence that use of glucocorticoids increases the risk of complicated peptic ulcer disease, limited data exist on how use of oral glucocorticoids affects outcome for patients with peptic ulcer perforation.
  79. ncbi Laparoscopic repair of perforated duodenal ulcers: the"three-stitch" Graham patch technique
    P W F Lam
    Department of Surgery, Caritas Medical Centre, No 111 Wing Hong Street, Shamshuipo, Hong Kong SAR, China
    Surg Endosc 19:1627-30. 2005
    ..However, it was not a popular approach because it had problems of suture entanglement and difficult laparoscopic suturing and knotting. The authors describe their technique and results...
  80. ncbi Laparoscopic treatment of gastroduodenal perforations: comparison with conventional surgery
    B Kirshtein
    Department of Surgery A, Soroka University Hospital, Post Office Box 151, Beer Sheva 84101, Israel
    Surg Endosc 19:1487-90. 2005
    Laparoscopic techniques have been proposed as an alternative to open surgery for the treatment of peptic ulcer perforation. This study compared the outcome of laparoscopic and open approaches for the repair of gastroduodenal perforations.
  81. ncbi Comparison between open and laparoscopic repair of perforated peptic ulcer disease
    Ricky H Bhogal
    University Hospitals of North Staffordshire and Keele Medical School, 42 Clay Lane, Oldbury, Warley, West Midlands, B69 4SY, UK
    World J Surg 32:2371-4. 2008
    ..This prospective study compared laparoscopic and open repair of perforated peptic ulcer disease. We evaluated whether the early results from laparoscopic repair resulted in improved patient outcome compared with conventional open repair...
  82. ncbi Comparison of laparoscopic versus open repair for perforated duodenal ulcers
    R Lunevicius
    Clinic of General and Plastic Surgery, Orthopedics and Trauma Surgery, Vilnius University, 29 Siltnamiu Street, Vilnius, LT 04130, Lithuania
    Surg Endosc 19:1565-71. 2005
    ..The purpose of this study was to compare the early outcome results of laparoscopic and open repair and to propose which risk factors influence the outcome...
  83. ncbi The efficacy of laparoscopic surgery in patients with peritonitis
    Mustafa Ates
    Department of General Surgery, Malatya State Hospital, Malatya, Turkey
    Surg Laparosc Endosc Percutan Tech 18:453-6. 2008
    ..The aim of the current study is to evaluate the safety and efficiency of laparoscopy and its role in patients with acute abdominal emergencies retrospectively...
  84. ncbi Endoscope-assisted laparoscopic repair of perforated peptic ulcers
    Kun Hua Lee
    Division of General Surgery, Changhua Christian Hospital, Changhua, Taiwan
    Am Surg 70:352-6. 2004
    ..We conclude that endoscope-assisted laparoscopic repair for PPU is safe and effective. This revised technique allows surgeons to exclude patients who are likely to fail the laparoscopic repair...
  85. ncbi Teflon-felt grafting of giant gastroduodenal perforation in a canine model
    Sung Pao Kung
    Department of Surgery, Taipei Veterans General Hospital and School of Medicine, National Yang Ming University, Taipei 112, Taiwan
    Surg Today 34:145-9. 2004
    ..However, it is still unclear if Teflon-felt can be used to effectively repair a fragile and giant gastroduodenal defect...
  86. pmc Laparoscopic suture repair of a perforated gastric ulcer in a severely cirrhotic patient with portal hypertension: first case report
    Paolo Gentileschi
    Department of Surgery, University of Tor Vergata, Rome, Italy
    JSLS 7:377-82. 2003
    ..Laparoscopy in this setting has the potential to reduce postoperative complications. Laparoscopic treatment of a perforated gastric ulcer in a severely cirrhotic patient with portal hypertension is herein described...
  87. ncbi Perforated peptic ulcer: open versus laparoscopic repair
    W Y Lau
    Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong
    Asian J Surg 25:267-9. 2002
  88. ncbi Color coding of sutures in laparoscopic perforated duodenal ulcer: a new concept
    Simon Wemyss-Holden
    Department of Surgery, Leicester Royal Infirmary, United Kingdom
    Surg Laparosc Endosc Percutan Tech 12:177-9. 2002
    ..The concept of suture color-coding may be applicable to other laparoscopic procedures where identification of "suture pairs" is difficult...
  89. ncbi Laparoscopic suture closure of perforated duodenal peptic ulcer
    Jean Pierre Arnaud
    Department of Digestive Surgery, Angers University Hospital, France
    Surg Laparosc Endosc Percutan Tech 12:145-7. 2002
    ..The results of our study show the feasibility of the laparoscopic approach for perforated peptic ulcer repair, with acceptable mortality and morbidity rates...
  90. ncbi Laparoscopic and endoscopic management of perforated duodenal ulcers
    Igor S Malkov
    Department of General and Emergency Surgery, Kazan State Medical Academy, Kazan, Russian Federation Russia
    J Am Coll Surg 198:352-5. 2004
    ..Laparoscopic management for plication has been safely applied in a variety of populations. This study assessed a combination of endoscopy and laparoscopy to manage early duodenal perforation...
  91. pmc The sixth decision regarding perforated duodenal ulcer
    Sandhya Lagoo
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    JSLS 6:359-68. 2002
    ....
  92. pmc Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects
    J Higham
    Office for National Statistics, 1 Drummond Gate, London SW1V 2QQ, UK
    Gut 50:460-4. 2002
    ....
  93. ncbi Do perforated duodenal ulcers need an acid-decreasing surgical procedure now that omeprazole is available?
    D V Feliciano
    Department of Surgery, Emory University School of Medicine, Atlanta, Georgia
    Surg Clin North Am 72:369-80. 1992
    ..abstract truncated at 400 words)..
  94. ncbi Comparison between open and laparoscopic technique in the management of perforated gastroduodenal ulcers
    Matthias H Seelig
    Department of Surgery, University Hospital Muenster, Muenster, Germany
    J Clin Gastroenterol 37:226-9. 2003
    ..The aim of this study was to evaluate our results of laparoscopic treatment of perforated gastroduodenal ulcers during a 5-year period and to compare the outcome of open and laparoscopic surgery...
  95. ncbi Perforated peptic ulcer--time trends and patterns over 20 years
    J Janik
    Department of Surgery, M Kopernik Hospital, Gdansk, Poland
    Med Sci Monit 6:369-72. 2000
    ..The source of analyzed data are operative reports. Several observations regarding number, age and sex of patients affected and ulcer location have been made...
  96. ncbi Ulcer complications associated with anti-inflammatory drug use. What is the extent of the disease burden?
    M J Langman
    Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Pharmacoepidemiol Drug Saf 10:13-9. 2001
    ..Substitution of completely safe anti-inflammatory analgesics and anti-platelet drugs would be expected to reduce admissions from 4121 to 1072, and deaths from 523 to 123...
  97. ncbi Effect of Helicobacter pylori eradication on the ulcer recurrence rate after simple closure of perforated duodenal ulcer: retrospective and prospective randomized controlled studies
    V Kate
    Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
    Br J Surg 88:1054-8. 2001
    ..CONCLUSION: Eradication of H. pylori after simple closure of a perforated duodenal ulcer should reduce the incidence of residual and recurrent ulcers...
  98. ncbi [Surgery of complicated gastroduodenal ulcers: outcome at the millennium]
    D Kreissler-Haag
    Abteilung für Allgemeine Chirurgie, Viszeral und Gefässchirurgie, Chirurgische Universitätsklinik des Saarlandes
    Zentralbl Chir 127:1078-82. 2002
    ..Altered ulcer manifestation by improvement of medical treatment as well as advances in surgical techniques and intensive care medicine might currently have improved the outcome of these severely ill patients...
  99. ncbi [Adverse effects of non-steroidal anti-inflammatory drugs. A prevalence study in Austria]
    Gernot Kolarz
    Institut für Rheumatologie der Kurstadt Baden in Kooperation mit der Donau Universität Krems, Baden, Osterreich
    Wien Klin Wochenschr 115:41-6. 2003
    ..However, there are no recent data from Austria. The aim of this prevalence study was therefore to assess the gastrointestinal risk from NSAID in Austria...
  100. ncbi [Laparoscopy in abdominal emergencies]
    Andrzej Bobrzynski
    II Katedra Chirurgii Ogólnej Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
    Przegl Lek 59:873-6. 2002
    ..Most frequently performed procedures in abdominal emergencies and trauma were presented. Indications, contraindications, advantages and drawbacks with regard to own experience and literature were discussed...
  101. ncbi Persistence of Helicobacter pylori infection in patients with peptic ulcer perforation
    Helena Andreson
    Department of Microbiology, University of Tartu, Tartu, Estonia
    Scand J Gastroenterol 42:324-9. 2007
    ..The objective of this study was to evaluate the persistence of infection by virulent H. pylori strains and ulcer recurrence in 33 patients with PPU one year after surgery and antimicrobial treatment...

Research Grants4

  1. Assessment of Infant Outcomes After in Utero Exposure to Antiretroviral Therapy
    Sonia Hernandez diaz; Fiscal Year: 2010
    ..We propose to evaluate the risk of congenital malformations and other adverse pregnancy outcomes following antenatal exposure to ART in a prospective cohort of pregnant women. ..
  2. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  3. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  4. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..