peptic ulcer

Summary

Summary: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Top Publications

  1. doi Guidelines for prevention of NSAID-related ulcer complications
    Frank L Lanza
    Baylor College of Medicine, Houston, Texas 77074, USA
    Am J Gastroenterol 104:728-38. 2009
  2. ncbi [Diagnosis and treatment guidelines for Helicobacter pylori infection in Korea]
    Nayoung Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Seoul, Korea
    Korean J Gastroenterol 54:269-78. 2009
  3. doi New look at antiplatelet agent-related peptic ulcer: an update of prevention and treatment
    Ping I Hsu
    Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital and National Yang Ming University, Kaohsiung, Taiwan
    J Gastroenterol Hepatol 27:654-61. 2012
  4. ncbi Effect of CYP2C19*17 gene variant on Helicobacter pylori eradication in peptic ulcer patients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 62:877-80. 2006
  5. doi Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis
    Ping I Hsu
    Kaohsiung Veterans General Hospital National Yang Ming University corrected
    Gastroenterology 140:791-8. 2011
  6. doi Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin
    Neville Yeomans
    School of Medicine, University of Western Sydney, Sydney, Australia
    Am J Gastroenterol 103:2465-73. 2008
  7. ncbi Helicobacter pylori virulence genes and host IL-1RN and IL-1beta genes interplay in favouring the development of peptic ulcer and intestinal metaplasia
    C F Zambon
    Department of Laboratory Medicine, University of Padova, Italy
    Cytokine 18:242-51. 2002
  8. pmc Prevention of peptic ulcers with esomeprazole in patients at risk of ulcer development treated with low-dose acetylsalicylic acid: a randomised, controlled trial (OBERON)
    James M Scheiman
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Heart 97:797-802. 2011
  9. doi Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial
    Joseph J Y Sung
    Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong
    Ann Intern Med 152:1-9. 2010
  10. doi Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses
    K Robinson
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham, UK
    Gut 57:1375-85. 2008

Detail Information

Publications393 found, 100 shown here

  1. doi Guidelines for prevention of NSAID-related ulcer complications
    Frank L Lanza
    Baylor College of Medicine, Houston, Texas 77074, USA
    Am J Gastroenterol 104:728-38. 2009
    ..pylori, it was elected by the Committee to confine these guidelines to upper gastrointestinal (GI) injury and to leave post-duodenal injury as the subject of a separate guideline...
  2. ncbi [Diagnosis and treatment guidelines for Helicobacter pylori infection in Korea]
    Nayoung Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Seoul, Korea
    Korean J Gastroenterol 54:269-78. 2009
    ..pylori eradication is early gastric cancer in addition to the previous indications of peptic ulcer including scar and Marginal zone B cell lymphoma (MALT type)...
  3. doi New look at antiplatelet agent-related peptic ulcer: an update of prevention and treatment
    Ping I Hsu
    Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital and National Yang Ming University, Kaohsiung, Taiwan
    J Gastroenterol Hepatol 27:654-61. 2012
    ....
  4. ncbi Effect of CYP2C19*17 gene variant on Helicobacter pylori eradication in peptic ulcer patients
    Mateusz Kurzawski
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 62:877-80. 2006
    Eradication of Helicobacter pylori is an important treatment strategy in peptic ulcer patients. Current regimens of eradication consist of proton pump inhibitor (PPI) and two antibiotics...
  5. doi Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis
    Ping I Hsu
    Kaohsiung Veterans General Hospital National Yang Ming University corrected
    Gastroenterology 140:791-8. 2011
    ..We also investigated the effects of esomeprazole on the antiplatelet action of clopidogrel...
  6. doi Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin
    Neville Yeomans
    School of Medicine, University of Western Sydney, Sydney, Australia
    Am J Gastroenterol 103:2465-73. 2008
    ..This study determined the efficacy of esomeprazole for reducing the risk of gastric and/or duodenal ulcers and dyspeptic symptoms in patients receiving continuous, low-dose aspirin therapy...
  7. ncbi Helicobacter pylori virulence genes and host IL-1RN and IL-1beta genes interplay in favouring the development of peptic ulcer and intestinal metaplasia
    C F Zambon
    Department of Laboratory Medicine, University of Padova, Italy
    Cytokine 18:242-51. 2002
    ..pylori positive and 137 H. pylori negative subjects (23 gastric adenocarcinoma, 58 peptic ulcer, 221 gastritis) were studied. oipA was sequenced, IL-1beta was RFLP analysed...
  8. pmc Prevention of peptic ulcers with esomeprazole in patients at risk of ulcer development treated with low-dose acetylsalicylic acid: a randomised, controlled trial (OBERON)
    James M Scheiman
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Heart 97:797-802. 2011
    ....
  9. doi Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial
    Joseph J Y Sung
    Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong
    Ann Intern Med 152:1-9. 2010
    It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin.
  10. doi Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses
    K Robinson
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham, UK
    Gut 57:1375-85. 2008
    ..To address the hypothesis that the human acquired immune response to H. pylori influences pathogenesis, we characterised the gastric T helper (Th) and regulatory T cell (Treg) response of infected patients...
  11. ncbi Peptic ulcer disease
    Kalyanakrishnan Ramakrishnan
    Department of Family and Preventive Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Am Fam Physician 76:1005-12. 2007
    b>Peptic ulcer disease usually occurs in the stomach and proximal duodenum. The predominant causes in the United States are infection with Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs...
  12. doi Hospitalisation of and mortality from bleeding peptic ulcer in Sweden: a nationwide time-trend analysis
    K Ahsberg
    Department of Surgery, Lund University Hospital, Lund University, Sweden
    Aliment Pharmacol Ther 33:578-84. 2011
    Time-trend analyses of incidence and mortality in bleeding peptic ulcer show divergent results.
  13. pmc Genome sequences of 65 Helicobacter pylori strains isolated from asymptomatic individuals and patients with gastric cancer, peptic ulcer disease, or gastritis
    Thomas G Blanchard
    Department of Pediatrics, University of Maryland, Baltimore, MD, USA
    Pathog Dis 68:39-43. 2013
    ..pylori isolates from individuals with gastric cancer, preneoplastic lesions, peptic ulcer disease, gastritis, and from asymptomatic adults...
  14. pmc Analysis of antimicrobial susceptibility and virulence factors in Helicobacter pylori clinical isolates
    Anita Paula Ortiz Godoy
    Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Braganca Paulista, SP, Brazil
    BMC Gastroenterol 3:20. 2003
    ..In addition, the vacA, iceA, cagA and cagE genotypes of strains isolated from Brazilian patients were determined and associated with clinical data in an effort to correlate these four virulence markers and antibiotic resistance...
  15. doi The ulcer sleuths: The search for the cause of peptic ulcers
    Neville D Yeomans
    University of Western Sydney, Sydney, Australia
    J Gastroenterol Hepatol 26:35-41. 2011
    ..The overwhelming evidence now is that the major etiologic factors in chronic peptic ulcer are ingestion of nonsteroidal anti-inflammatory drugs (NSAIDs) and infection with Helicobacter pylori...
  16. ncbi Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Gastroenterol Hepatol 22:51-9. 2007
    ..The aim of this study was to clarify the association of polymorphisms of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha with susceptibility to peptic ulcer diseases and gastric cancer in Japan.
  17. ncbi Proton-pump inhibitors reduce the risk of uncomplicated peptic ulcer in elderly either acute or chronic users of aspirin/non-steroidal anti-inflammatory drugs
    A Pilotto
    Unita Operativa di Geriatria, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy
    Aliment Pharmacol Ther 20:1091-7. 2004
    ....
  18. doi Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats
    V Lakshmi
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, U P, India
    Phytomedicine 17:569-74. 2010
    ..This study is the first of its kind to show significant anti-secretory effect of gedunin and photogedunin. Therefore it could act as a potent therapeutic agent against peptic ulcer disease.
  19. doi Validation and psychometric properties of Chinese version of SF-36 in patients with hypertension, coronary heart diseases, chronic gastritis and peptic ulcer
    Z Yang
    School of Public Health, Guangdong Medical College, Dongguan, China
    Int J Clin Pract 66:991-8. 2012
    ..version of the SF-36 (CSF-36) is rarely used for those patients with hypertension, coronary heart diseases, chronic gastritis and peptic ulcer in China. Therefore, the CSF-36 needs to be validated in patients with chronic diseases.
  20. doi Systematic review of the symptom burden, quality of life impairment and costs associated with peptic ulcer disease
    Alan Barkun
    Division of Gastroenterology, McGill University, Montreal, Quebec, Canada
    Am J Med 123:358-66.e2. 2010
    Management of peptic ulcer disease has improved over the past few decades...
  21. ncbi The cost-effectiveness of population Helicobacter pylori screening and treatment: a Markov model using economic data from a randomized controlled trial
    J Mason
    Centre for Health Economics, University of York, York, UK
    Aliment Pharmacol Ther 16:559-68. 2002
    ..These models are conservative as they do not consider that the programme may reduce health service peptic ulcer and other dyspepsia costs. We have evaluated the economic impact of population H...
  22. doi Evaluation of Helicobacter pylori eradication by triple therapy plus Lactobacillus acidophilus compared to triple therapy alone
    J A da Silva Medeiros
    Institute of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Eur J Clin Microbiol Infect Dis 30:555-9. 2011
    ..acidophilus, at this dose, shows no benefit. Further studies with different dosages and duration of treatment, and other probiotics or probiotic combinations are required to improve eradication...
  23. ncbi Epidemiology and clinical presentation of stress-related peptic damage and chronic peptic ulcer
    Rok Seon Choung
    Dyspepsia Center and Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Florida, USA
    Curr Mol Med 8:253-7. 2008
    ..Various types of stress may play a role in the onset and modulation of acute or chronic peptic ulcer disease...
  24. pmc Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer
    Mitsushige Sugimoto
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    World J Gastroenterol 16:1188-200. 2010
    ..of interleukin (IL)-1B, IL-1RN and TNF-A have been reported to relate well with gastric cancer and peptic ulcer risk, those of IL-2, IL-4, IL-6 and IL-8 genes are unclear...
  25. ncbi Upper gastrointestinal bleeding in a Brazilian hospital: a retrospective study of endoscopic records
    Cyrla Zaltman
    Department of Internal Medicine, School of Medicine, Federal University of Rio de Janeiro, Brasil
    Arq Gastroenterol 39:74-80. 2002
    ..Aims - To assess the clinical characteristics, endoscopic accuracy, treatment efficiency and clinical outcome of patients admitted to the endoscopic unit with upper gastrointestinal bleeding...
  26. pmc Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries
    Y Yamaoka
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Microbiol 37:2274-9. 1999
    ..pylori isolates obtained from patients with different clinical presentations (peptic ulcer, gastric cancer, and atrophic gastritis). The H...
  27. ncbi Recent trends in hospital admissions and mortality rates for peptic ulcer in Scotland 1982-2002
    J Y Kang
    Department of Gastroenterology, St George s Hospital, London, UK
    Aliment Pharmacol Ther 24:65-79. 2006
    While overall hospital admission rates for peptic ulcer declined in England in the 1990 s, they increased among the elderly, especially for complicated ulcer. However, peptic ulcer admissions fell for all age groups in the United States.
  28. doi Nonsteroidal antiinflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: a trip from peptic ulcer to colon cancer
    Angel Lanas
    Service of Digestive Diseases, University Hospital, CIBERehd IACS, University of Zaragoza, Zaragoza, Spain
    Am J Med Sci 338:96-106. 2009
    ..Adverse effects of NSAIDs and aspirin in the upper GI tract include esophagitis, peptic ulcer, peptic ulcer complications, and death...
  29. ncbi Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and haemorrhage
    E M van Soest
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 26:265-75. 2007
    ..Upper gastrointestinal (UGI) complications are a well-recognized risk of NSAID treatment, requiring preventive measures in high-risk patients. Adherence to gastroprotective agents (GPAs) in NSAID users has been suggested to be suboptimal...
  30. pmc Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer
    Steffen Backert
    Department of Medical Microbiology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Infect Immun 72:1043-56. 2004
    ..pylori isolates obtained from 75 patients with gastritis, peptic ulcer, and gastric cancer (n = 25 in each group)...
  31. doi Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions
    Fook Hong Ng
    Department of Medicine and Geriatric, Ruttonjee Hospital, Hong Kong, China
    Gastroenterology 138:82-8. 2010
    ..We compared the efficacy of high-dose famotidine with that of pantoprazole in preventing recurrent symptomatic ulcers/erosions...
  32. ncbi Seroepidemiological study of Helicobacter pylori infection in asymptomatic people in South Korea
    J H Kim
    Kangdong Sacred Heart Hospital, Seoul, Korea
    J Gastroenterol Hepatol 16:969-75. 2001
    ..The prevalence of H. pylori infection varies between countries and races. The aim of this study was to evaluate the seroprevalence of H. pylori infection in asymptomatic healthy people in South Korea...
  33. ncbi Celecoxib versus diclofenac plus omeprazole in high-risk arthritis patients: results of a randomized double-blind trial
    Francis K L Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Gastroenterology 127:1038-43. 2004
    ..We studied the ulcer incidence and factors predicting ulcer recurrence in a prospective, double-blinded trial...
  34. ncbi Pathophysiology and prophylaxis of stress ulcer in intensive care unit patients
    Neil Stollman
    Division of Gastroenterology, Department of Medicine, University of California San Francisco, 94110, USA
    J Crit Care 20:35-45. 2005
    ..The prophylactic regimen chosen to prevent stress ulcer bleeding should take into account the risk factors and underlying disease state of individual patients to provide the best therapy to those most likely to benefit...
  35. doi Peptic ulcer disease
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Lancet 374:1449-61. 2009
    b>Peptic ulcer disease had a tremendous effect on morbidity and mortality until the last decades of the 20th century, when epidemiological trends started to point to an impressive fall in its incidence...
  36. doi Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease
    Chun Ying Wu
    Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan
    Gastroenterology 137:1641-8.e1-2. 2009
    Helicobacter pylori (H pylori) is a risk factor for gastric cancer. We investigated whether early H pylori eradication is associated with gastric cancer risk in patients with peptic ulcer diseases.
  37. ncbi [Inter-departmental differences in the eradication therapy for Helicobacter pylori infection: a single center study]
    Woo Chul Chung
    Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Korean J Gastroenterol 53:221-7. 2009
    ..Apart from the antibiotic resistance and patients compliance, various factors have an influence on the efficacy of eradication therapy. We analyzed the inter-departmental differences in the eradication therapy for H. pylori infection...
  38. doi Acid-NSAID/aspirin interaction in peptic ulcer disease
    Richard H Hunt
    Farncombe Family Digestive Health Research Institute, Division of Gastroenterology, McMaster University Health Science Centre, Hamilton, Ont, Canada
    Dig Dis 29:465-8. 2011
    ..PPI co-therapy is still recommended in patients receiving dual antiplatelet treatment, although conflicting results have been reported about adverse drug interactions between PPIs and clopidogrel...
  39. doi CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease
    C O Musumba
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Clin Pharmacol Ther 93:195-203. 2013
    ..been extensively investigated as predisposing factors for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer disease (PUD) or upper gastrointestinal bleeding (UGIB)...
  40. doi The prevalence and incidence of Helicobacter pylori-associated peptic ulcer disease and upper gastrointestinal bleeding throughout the world
    Andrew Y Wang
    Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Gastrointest Endosc Clin N Am 21:613-35. 2011
    ..infection, the prevalence and incidence of H pylori infection (and by extension the prevalence and incidence of peptic ulcer disease) appear to have declined in recent years...
  41. ncbi Diabetes and 30-day mortality from peptic ulcer bleeding and perforation: a Danish population-based cohort study
    Reimar W Thomsen
    Department of Clinical Epidemiology, Aarhus University Hospital, DK 9100 Aalborg, Denmark
    Diabetes Care 29:805-10. 2006
    Diabetes may influence the outcome of complicated peptic ulcer disease, due to angiopathy, blurring of symptoms, and increased risk of sepsis...
  42. ncbi Helicobacter pylori is a risk factor for peptic ulcer disease in cirrhotic patients. A meta-analysis
    Mercedes Vergara
    Unitat de Malalties Digestives, Corporacio Parc Tauli, Parc Tauli s n, 08208 Sabadell, Barcelona, Spain
    Eur J Gastroenterol Hepatol 14:717-22. 2002
    b>Peptic ulcer disease is highly prevalent in cirrhosis, and ulcer complications are a major cause of morbidity in these patients. Helicobacter pylori infection is considered the chief aetiological factor of ulcer disease...
  43. doi Gastroprotective drugs in Australia: utilization patterns between 1997 and 2006 in relation to NSAID prescribing
    Nadia Barozzi
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Clin Ther 31:849-61. 2009
    ..PPI prescribing increased in Australia between 1997 and 2006, and some authorities are concerned that this increase may be due to prescriptions outside the approved indications...
  44. doi Discontinuation of low-dose aspirin therapy after peptic ulcer bleeding increases risk of death and acute cardiovascular events
    Maryam Derogar
    Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Norra Stationsgatan 67, Stockholm, Sweden
    Clin Gastroenterol Hepatol 11:38-42. 2013
    Little is known about how discontinuation of low-dose aspirin therapy after peptic ulcer bleeding affects patient mortality or acute cardiovascular events.
  45. ncbi Clarithromycin-based triple therapy for Helicobacter pylori treatment in peptic ulcer patients
    Guilherme Felga
    School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Infect Dev Ctries 4:712-6. 2010
    ..The scheme proton pump inhibitor/amoxicillin/clarithromycin (PPI/AC) is still the first-line treatment for Helicobacter pylori (H. pylori) infections despite evidence suggesting its failure in up to 20% to 30% of patients...
  46. doi Complications of peptic ulcer disease
    Tomica Milosavljevic
    Clinical Center of Serbia, Gastroenterology and Hepatology Clinic, University of Belgrade, Faculty of Medicine, Belgrade, Serbia
    Dig Dis 29:491-3. 2011
    There are four major complications of peptic ulcer disease (PUD): bleeding, perforation, penetration, and obstruction. Complications can occur in patients with peptic ulcer of any etiology...
  47. ncbi Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Gastroenterol Hepatol 22:1443-9. 2007
    ..The aim of the present study was to clarify the association between the IL-10 polymorphism, one of the representative anti-inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan.
  48. pmc Different risk factors influence peptic ulcer disease development in a Brazilian population
    Rodrigo Buzinaro Suzuki
    Department of Genotyping, Hemocenter, Marilia Medical School, Marilia 17519 030, Sao Paulo, Brazil
    World J Gastroenterol 18:5404-11. 2012
    ..To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients...
  49. doi Antiplatelet and anticoagulant therapy in patients with gastrointestinal bleeding: an 86-year-old woman with peptic ulcer disease
    Majid A Almadi
    Division of Gastroenterology, Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    JAMA 306:2367-74. 2011
    ..The recurrence rate for bleeding in patients who continue to take aspirin after an episode of peptic ulcer disease-related bleeding can reach up to 300 cases per 1000 person-years and varies by age, sex, and the use of ..
  50. doi Weekend versus weekday admission and mortality from gastrointestinal hemorrhage caused by peptic ulcer disease
    Abdel Aziz M Shaheen
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin Gastroenterol Hepatol 7:303-10. 2009
    ..Management of upper gastrointestinal bleeding (UGIB) often requires urgent endoscopic intervention; limitations in its availability on weekends might be associated with increased mortality, compared with patients admitted on weekdays...
  51. doi Epidemiology of peptic ulcer disease: endoscopic results of the systematic investigation of gastrointestinal disease in China
    Zhaoshen Li
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
    Am J Gastroenterol 105:2570-7. 2010
    Complications of peptic ulcer disease (PUD) are common in China. Population-based estimates of the prevalence of PUD are needed to quantify and characterize the population at risk of these complications.
  52. doi Aspirin-induced peptic ulcer and genetic polymorphisms
    Akiko Shiotani
    Department of Internal Medicine, Kawasaki Medical School, Matsushima Kurashiki City, Okayama, Japan
    J Gastroenterol Hepatol 25:S31-4. 2010
    ..had lower prostaglandin synthesis capacity, lacking statistical significance in the association with bleeding peptic ulcer. A recent Japanese study indicated that the number of COX-1-1676T alleles was a significant risk factor for ..
  53. ncbi Has peptic ulcer disease changed during the past ten years in Korea? A prospective multi-center study
    Hyun Joo Jang
    Department of Gastroenterology, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea
    Dig Dis Sci 53:1527-31. 2008
    The incidence of H. pylori-negative, idiopathic peptic ulcer disease (IPUD) seems to be increasing with the changing trends of PUD and H. pylori infection in some developed countries.
  54. doi Geranylgeranylacetone protects against diclofenac-induced gastric and small intestinal mucosal injuries in healthy subjects: a prospective randomized placebo-controlled double-blind cross-over study
    Yasumasa Niwa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Digestion 80:260-6. 2009
    ..We planned a pilot study to investigate the protective effects of geranylgeranylacetone (GGA) against NSAID-induced small intestinal injuries using video capsule endoscopy (VCE)...
  55. ncbi The epidemiology of nonsteroidal anti-inflammatory drugs
    J Tenenbaum
    Mount Sinai Hospital, Toronto, Canada
    Can J Gastroenterol 13:119-22. 1999
    ..The point prevalence of NSAID-induced ulcers is 10% to 30%, and 15% to 35% of all peptic ulcer complications are caused by NSAIDs...
  56. ncbi Management of peptic ulcer disease not related to Helicobacter pylori or NSAIDs
    Carolyn Quan
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
    Am J Gastroenterol 97:2950-61. 2002
    ..pylori, the prevalence of H. pylori is changing, and H. pylori-negative peptic ulcer disease appears to be increasing. When making a diagnosis of H...
  57. ncbi Characteristics of Helicobacter pylori-induced gastritis and the effect of H. pylori eradication in patients with chronic idiopathic thrombocytopenic purpura
    Takafumi Ando
    Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Helicobacter 9:443-52. 2004
    ..We investigated the prevalence of H. pylori infection, its virulence profile and the effectiveness of its eradication in patients with ITP...
  58. ncbi Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots
    Dennis M Jensen
    CURE Digestive Disease Research Center, UCLA School of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Gastroenterology 123:407-13. 2002
    ..Our purpose was to test the hypothesis that patients treated with combination endoscopic therapy would have significantly lower rebleeding rates than those treated with medical therapy...
  59. ncbi Relevance of vacA genotypes of Helicobacter pylori to cagA status and its clinical outcome
    S M Park
    Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea
    Korean J Intern Med 16:8-13. 2001
    ..was to assess the relationship of vacA genotypes of Helicobacter pylori to cagA status and its development of peptic ulcer diseases in Korean patients...
  60. ncbi Prevention and treatment of non-steroidal anti-inflammatory drug-induced gastro-duodenal damage: rationale for the use of antisecretory compounds
    C Scarpignato
    Department of Internal Medicine, School of Medicine and Dentistry, University of Parma, Italy
    Ital J Gastroenterol Hepatol 31:S63-72. 1999
    ..Further studies are, therefore, needed to better elucidate the respective role of the various pharmacological actions in their mucosal protective activity as well as to assess the clinical relevance of each of them...
  61. pmc Association between acute pancreatitis and peptic ulcer disease
    Kang Moon Lee
    Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Gyeonggi Do, South Korea
    World J Gastroenterol 17:1058-62. 2011
    To evaluate the relationship between peptic ulcer disease (PUD) and acute pancreatitis.
  62. doi Randomised clinical trial: esomeprazole for the prevention of nonsteroidal anti-inflammatory drug-related peptic ulcers in Japanese patients
    K Sugano
    Department of Medicine, Jichi Medical University, Shimotsuke, Japan
    Aliment Pharmacol Ther 36:115-25. 2012
    ..However, data regarding the efficacy and safety of this approach in Japan are scarce...
  63. pmc Clinical Relevance of the vacA, iceA, cagA, and flaA genes of Helicobacter pylori strains isolated in Eastern Taiwan
    Chao Chuan Wu
    Department of Surgery, Tzu Chi University, Hualien 970, Taiwan
    J Clin Microbiol 43:2913-5. 2005
    ..pylori flaA, cagA, vacA, and iceA were determined for DNA isolated from patients with chronic gastritis or peptic ulcer in eastern Taiwan...
  64. doi Is childhood physical abuse associated with peptic ulcer disease? Findings from a population-based study
    Esme Fuller-Thomson
    Factor Inwentash Faculty of Social Work, University of Toronto, Ontario, Canada
    J Interpers Violence 26:3225-47. 2011
    ..Two recent studies demonstrate a potential link between childhood physical abuse and peptic ulcer disease in adulthood...
  65. ncbi Presence of iceA1 but not cagA, cagC, cagE, cagF, cagN, cagT, or orf13 genes of Helicobacter pylori is associated with more severe gastric inflammation in Taiwanese
    Shew Meei Sheu
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
    J Formos Med Assoc 101:18-23. 2002
    ..This study determined the prevalence of genotypes of the PAI, IS605, and iceA1 in H. pylori strains in Taiwanese and whether these genotypes were related to the type of clinical disease or gastric pathology...
  66. ncbi Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group
    C Bombardier
    Institute for Work and Health, Mount Sinai Hospital, and The University Health Network, Toronto, ON, Canada
    N Engl J Med 343:1520-8, 2 p following 1528. 2000
    ....
  67. ncbi Eradication rates of helicobacter pylori infection with second-line treatment: non-ulcer dyspepsia compared to peptic ulcer disease
    Su Jin Chung
    The Liver Research Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Hepatogastroenterology 54:1293-6. 2007
    ..pylori) infection is less effective in patients with nonulcer dyspepsia (NUD) than those with peptic ulcer disease (PUD)...
  68. ncbi Lansoprazole fast disintegrating tablet: a new formulation for an established proton pump inhibitor
    Fabio Baldi
    Department of Gastroenterology, Metabolic and Infectious Diseases, S Orsola Malpighi Hospital, Bologna, Italy
    Digestion 67:1-5. 2003
    ..The new formulation may be of particular benefit to those with active life-styles who do not always have water available, patients who have difficulty in swallowing, and elderly patients...
  69. ncbi Peptic ulcer/stricture after gastric bypass: a comparison of technique and acid suppression variables
    G Darby Pope
    Department of Surgery, Dartmouth Medical School, Dartmouth Hitchock Medical Center, Lebanon, NH 03756, USA
    Obes Surg 12:30-3. 2002
    ..Our series of GBP patients was reviewed to determine what technical or management factors, if any, were associated with U/S...
  70. pmc CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease
    Effrosini G Panayotopoulou
    Laboratory of Medical Microbiology, Hellenic Pasteur Institute, Athens, Greece
    J Clin Microbiol 48:2237-9. 2010
    ..647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632)...
  71. pmc Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?
    Katsuhiro Mabe
    Division of Gastroenterology, KKR Sapporo Medical Center, Sapporo City 062 0931, Hokkaido, Japan
    World J Gastroenterol 15:4290-7. 2009
    To investigate the effects of Helicobacter pylori (H pylori) eradication therapy for treatment of peptic ulcer on the incidence of gastric cancer.
  72. doi Proinflammatory cytokines and thrombomodulin in patients with peptic ulcer disease and gastric cancer, infected with Helicobacter pylori
    Mehrdad Haghazali
    Department of Pathology and Gastroenterology, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University, M C, Tehran, Iran
    Indian J Pathol Microbiol 54:103-6. 2011
    Helicobacter pylori infect more than half of the global population. It is suggested to be related with gastritis, peptic ulcer disease (PUD), and gastric cancer.
  73. ncbi Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial
    Francis K L Chan
    Departments of Medicine and Therapeutics, The Chinese University of Hong Kong, Special Administrative Region of China, Hong Kong
    Lancet 359:9-13. 2002
    ..We hypothesised that eradication of H pylori infection would reduce the risk of ulcers for patients starting long-term NSAID treatment...
  74. ncbi Intravenous omeprazole in critically ill patients: a randomized, crossover study comparing 40 with 80 mg plus 8 mg/hour on intragastric pH
    P F Laterre
    Department of Critical Care Medicine, Cliniques Universitaires St Luc, Brussels, Belgium
    Crit Care Med 29:1931-5. 2001
    ..To compare intravenous omeprazole 40-mg single dose with 8 mg/hr after an 80-mg bolus injection on 24-hr intragastric pH in intensive care unit (ICU) ventilated patients...
  75. doi Systematic review of peptic ulcer disease incidence rates: do studies without validation provide reliable estimates?
    Kueiyu Joshua Lin
    Department of Epidemiology, Harvard School of Public Health, Boston, USA
    Pharmacoepidemiol Drug Saf 20:718-28. 2011
    Incidence rate (IR) estimates for peptic ulcer disease (PUD) vary widely among studies. We conducted a systematic review to quantify and examine the discrepancies.
  76. ncbi Epidemiology of peptic ulcer disease in Wuhan area of China from 1997 to 2002
    Wei Guo Dong
    Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 10:3377-9. 2004
    To describe the epidemiological features of peptic ulcer disease in Wuhan area during 1997-2002, to analyze the sex, age and occupation characteristics, as well as the geographic distribution of peptic ulcer disease, and to determine the ..
  77. pmc Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications
    Sonia Hernandez-Diaz
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    BMC Med 4:22. 2006
    ....
  78. ncbi Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients
    T Kamada
    Department of Internal Medicine, Kawasaki Medical School, Matsushima 577, Kurashiki 701 0192, Japan
    Dig Liver Dis 37:39-43. 2005
    Eradication of Helicobacter pylori improves clinical symptoms and quality of life in patients with peptic ulcer.
  79. doi Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial
    Ali S Taha
    Gastroenterology Unit, Crosshouse Hospital, University of Glasgow, Kilmarnock, UK
    Lancet 374:119-25. 2009
    ..We therefore investigated the efficacy of famotidine, a well-tolerated histamine H(2)-receptor antagonist, in the prevention of peptic ulcers and erosive oesophagitis in patients receiving low-dose aspirin for vascular protection...
  80. ncbi Low prevalence of Helicobacter pylori but high prevalence of cytomegalovirus-associated peptic ulcer disease in AIDS patients: Comparative study of symptomatic subjects evaluated by endoscopy and CD4 counts
    Han Mo Chiu
    Departments of Internal Medicine and Pathology, National Taiwan University Hospital, Taipei, Taiwan
    J Gastroenterol Hepatol 19:423-8. 2004
    ..pylori and cytomegalovirus (CMV) infection in AIDS patients and HIV-negative controls. The impact of CD4 lymphocyte counts on H. pylori and CMV infection in the same subjects was also assessed...
  81. pmc Accuracy of Helicobacter pylori serology in two peptic ulcer populations and in healthy controls
    Rolv Ole Lindsetmo
    Department of Gastrointestinal Surgery, University Hospital of North Norway, and Institute of Clinical Medicine, Tromso University, Tromso, Norway
    World J Gastroenterol 14:5039-45. 2008
    ..of Helicobacter pylori (H pylori) serology and of C14-urea breath test (C14-UBT) in two different peptic ulcer populations and in community controls...
  82. doi Trends and outcomes of hospitalizations for peptic ulcer disease in the United States, 1993 to 2006
    Y Richard Wang
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Ann Surg 251:51-8. 2010
    Despite progress in diagnosis and treatment, peptic ulcer disease (PUD) remains a common reason for hospitalization and operation...
  83. doi Systematic review: the global incidence and prevalence of peptic ulcer disease
    J J Y Sung
    Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, Hong Kong, China
    Aliment Pharmacol Ther 29:938-46. 2009
    b>Peptic ulcer disease (PUD) is most commonly associated with Helicobacter pylori infection and the use of acetylsalicylic acid (ASA) and nonsteroidal anti-inflammatory drugs (NSAIDs). The management of H...
  84. ncbi An overview of acetic acid ulcer models--the history and state of the art of peptic ulcer research
    Susumu Okabe
    Department of Applied Pharmacology, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 602 0897, Japan
    Biol Pharm Bull 28:1321-41. 2005
    ..We conclude that acetic acid ulcer models are quite useful for various studies related to peptic ulcers...
  85. doi Differences in peptic ulcer between the East and the West
    Rupert W Leong
    Concord Hospital, Ambulatory Care Endoscopy Unit, Level 1 West, Hospital Road, Concord, Sydney NSW 2139, Australia
    Gastroenterol Clin North Am 38:363-79. 2009
    ..The magnitude of the problem, however, varies within these regions. The study of peptic ulcer epidemiology is impeded by the paucity of general population-based data, invasiveness of diagnostic tests, and ..
  86. ncbi Recrudescence and reinfection with Helicobacter pylori after eradication therapy in Bangladeshi adults
    P Hildebrand
    Department of Research, University Hospital, Basel, Switzerland
    Gastroenterology 121:792-8. 2001
    ..pylori after eradication therapy occurs within the first 3 months. The reinfection rate is high and might influence cost-benefit analyses for determining diagnostic and therapeutic procedures...
  87. doi Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms
    Daniela Basso
    Department of Laboratory Medicine, University of Padova, Padova, Italy
    Gastroenterology 135:91-9. 2008
    ..We assessed the association of new and established cagA and vacA polymorphisms with disease...
  88. ncbi [Eradication rate of first-line and second-line therapy for Helicobacter pylori infection, and reinfection rate after successful eradication]
    Hyun Sik Na
    Department of Internal Medicine, Institute for Digestive Research, Soonchunhyang University School of Medicine, Bucheon and Seoul, Korea
    Korean J Gastroenterol 50:170-5. 2007
    ..The aim of this study was to evaluate the recent 5-year changes of eradication rates and the reinfection rates after the successful eradication of Helicobacter pylori infection for 3-years follow-up in Bucheon, Korea...
  89. ncbi Helicobacter pylori cag pathogenicity island genes: clinical relevance for peptic ulcer disease development in Brazil
    Rejane Mattar
    Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, SP, Brazil
    J Med Microbiol 56:9-14. 2007
    ..cagM, tnpB, tnpA, cagT and the left end of the cag II (LEC) region--would be a useful marker for the risk of peptic ulcer disease development. H...
  90. ncbi Celecoxib compared with lansoprazole and naproxen to prevent gastrointestinal ulcer complications
    Kam Chuen Lai
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Med 118:1271-8. 2005
    ..We compared the efficacy of a selective COX-2 inhibitor with that of proton pump inhibitor co-therapy in the reduction in the incidence of ulcer relapse in patients with a history of NSAID-related peptic ulcers...
  91. pmc Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications
    Ramalinga R Kedika
    VA North Texas Healthcare System, Dallas, TX, USA
    Dig Dis Sci 54:2312-7. 2009
    ....
  92. pmc Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan
    Shiho Yamazaki
    Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    J Clin Microbiol 43:3906-16. 2005
    ..addition, the prevalence of infection with the Western group strain was significantly higher in patients with peptic ulcer (90.0%, 9/10) than in patients with chronic gastritis (22.7%, 5/22) (chi2 = 12.64, P = 0.00057)...
  93. pmc Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish adults
    S Rosenstock
    Copenhagen County Centre for Preventive Medicine, Glostrup University Hospital, Building 8 7 Nordre Ringvej, DK 2600 Glostrup, Denmark
    Gut 52:186-93. 2003
    No population based prospective cohort study has previously assessed the impact of multiple risk factors, including Helicobacter pylori infection, on the incidence of peptic ulcer disease (PUD).
  94. pmc Genotyping CagA, VacA subtype, IceA1, and BabA of Helicobacter pylori isolates from Korean patients, and their association with gastroduodenal diseases
    S Y Kim
    Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Korea
    J Korean Med Sci 16:579-84. 2001
    ..Seventy-six strains of H. pylori were isolated from the antrum and the corpus of 41 adult patients (22 with peptic ulcer and 19 with gastritis)...
  95. ncbi Medicinal plants used for peptic ulcer in the Bangangte region, western Cameroon
    E Noumi
    Laboratoire de Biologie végétale, Ecole Normale Superieure, Universite de Yaounde I, BP 47 Yaoundé, Cameroon
    Fitoterapia 71:406-12. 2000
    ..Thirty-nine plant species, traditionally used to treat peptic ulcers in the Bangangte region, Western Cameroon, are reported...
  96. ncbi Changing pattern of antimicrobial resistance of Helicobacter pylori in Korean patients with peptic ulcer diseases
    Chang Soo Eun
    Department of Internal Medicine, Hanyang University Kuri Hospital, 249 1 Kyomun dong, Kuri si, Kyunggi Do 471 701, Korea
    J Gastroenterol 38:436-41. 2003
    ..The aim of this study was to assess the prevalence of H. pylori antibiotic resistance at a single center in Korea, and the changes in its antimicrobial resistance, and to detect the mutation foci of clarithromycin-resistant strains...
  97. doi Antiplatelet therapy, Helicobacter pylori infection and complicated peptic ulcer disease in diabetes: the Fremantle Diabetes Study
    K Schimke
    University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, Australia
    Diabet Med 26:70-5. 2009
    To assess whether, based on its relationship with complications of peptic ulcer disease (PUD), directed Helicobacter pylori serological screening is justified in diabetic patients prior to commencement of antiplatelet therapy.
  98. ncbi Association between Helicobacter pylori-related peptic ulcer tissue and somatic mitochondrial DNA mutations
    Soong Lee
    Clin Chem 53:1390-2. 2007
  99. pmc Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: a study from northern India
    Ashish Saxena
    Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    World J Gastroenterol 14:1498-503. 2008
    To investigate -765G > C COX-2 polymorphism and H pylori infection in patients with gastric adenocarcinoma, peptic ulcer disease (PUD) and non-ulcer dyspepsia (NUD).
  100. ncbi Pantoprazole: an update of its pharmacological properties and therapeutic use in the management of acid-related disorders
    Susan M Cheer
    Adis International Limited, Miarangi Bay, Auckland, New Zealand
    Drugs 63:101-33. 2003
    ..Thus, pantoprazole is a valuable alternative to other PPIs in the treatment of acid-related disorders...

Research Grants63

  1. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The acquisition of Helicobacter pylori and its clinical sequelae of peptic ulcer disease and gastric cancer remain substantial health concerns for our Veterans. H...
  2. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..desired anti-inflammatory effects are generally accompanied by drastic side effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others upon chronic use...
  3. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..desired anti-inflammatory effects are generally accompanied by drastic side effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others upon chronic use...
  4. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    Helicobacter pylori (Hp) infection is the major cause of gastric inflammation, peptic ulcer disease, and gastric cancer...
  5. THE ROLE OF CELL SHAPE AND CELL WALL IN HELICOBACTER PYLORI PATHOGENESIS
    NINA REDA SALAMA; Fiscal Year: 2010
    ..a helical bacterium that colonizes the human stomach causing clinical outcomes ranging from mild gastritis to peptic ulcer and gastric cancer. Descriptions of H...
  6. Structure and function of Helicobacter pylori VacA
    Timothy L Cover; Fiscal Year: 2013
    ..containing certain forms of vacA (termed s1, i1, or m1) are associated with a higher risk of gastric cancer or peptic ulcer disease than are strains containing other forms of vacA (termed s2, i2, or m2)...
  7. Compounds to treat Helicobacter pylori infection
    Kenneth Coleman; Fiscal Year: 2013
    ..project is to discover lead compounds acting specifically against Helicobacter pylori, the causative agent of peptic ulcer and gastric carcinoma. Roughly every other person carries the pathogen, and there are an estimated 1...
  8. Acid Adaptation Targets for Eradication of Helicobacter pylori
    George Sachs; Fiscal Year: 2013
    ..This infection is a primary cause of peptic ulcer disease and a high risk factor for gastric cancer. Therefore, eradication of this H...
  9. DNA recombinational repair in Helicobacter pylori
    Ge Wang; Fiscal Year: 2010
    ..Helicobacter pylori persistently infects the human gastric mucosa and causes serious conditions such as peptic ulcer disease and gastric cancers. Studying the DNA recombinational repair system will help us understand how H...
  10. Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
    Hartmut Luecke; Fiscal Year: 2013
    ..Infection of the gastric mucosa by Helicobacter pylori remains a worldwide problem and contributes to peptic ulcer disease and gastric cancer...
  11. Genetic and Biochemical Analysis of DNA Exchange in Helicobacter pylori
    MARION SHONN DORER; Fiscal Year: 2010
    ..Inflammation caused by H. pylori puts the infected population at increased risk for chronic gastritis, peptic ulcer disease, and gastric cancers, the second leading cause of cancer-related deaths in the world [2]...
  12. Oxidative Injury to Gastric Epithelial Cells by H. pylori
    Sheila E Crowe; Fiscal Year: 2013
    ..pylori infection and other injury to the gastric epithelium lead to human disease including peptic ulcer disease and gastric carcinoma...
  13. Narrow-spectrum Agents Acting against Helicobacter pylori
    Kenneth Coleman; Fiscal Year: 2013
    ..project is to develop a therapeutic acting specifically against Helicobacter pylori, the causative agent of peptic ulcer and gastric carcinoma...
  14. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    Jay V Solnick; Fiscal Year: 2012
    ..pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. H...
  15. Mechanism of H. pylori-induced risk reduction for inflammatory bowel disease
    Jay Luther; Fiscal Year: 2009
    ..H. pylori infection has clearly been linked to the development of gastritis, peptic ulcer disease and certain gastric malignancies, yet close to 90% of infected individuals will remain asymptomatic ..
  16. Anti-inflammatory actions of bone morphogenetic protein signaling in the stomach
    Andrea Todisco; Fiscal Year: 2013
    ..and functional features of the gastric mucosa, leading to the development of diseases such as gastritis, peptic ulcer and gastric cancer...
  17. Mass Spectrometric Characterization of Lipopolysaccharides
    Jennifer S Brodbelt; Fiscal Year: 2013
    ..Helicobacter pylori is now recognized as the primary cause of peptic ulcer disease and gastric cancer, Camphorbacter jejuni and Vibrio cholera remain among the most common causes of ..
  18. Pathways and pathogens affecting gastric epithelial repair in vivo
    Marshall H Montrose; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Peptic ulcer disease remains a significant burden in the US healthcare system and worldwide, caused in large part by the presence of the gastric pathogen Helicobacter pylori or the upper GI toxicity ..
  19. Defensin gene copy number and mucosal innate immunity
    JAY V contact SOLNICK; Fiscal Year: 2010
    ..BD2 expression is induced by Helicobacter pylori, a common gastric pathogen that is the causative agent of peptic ulcer and increases the risk for gastric cancer...
  20. The Gastric Biology of Helicobacter Pylori
    George Sachs; Fiscal Year: 2012
    ..This research may provide new leads for improvement eradication therapy thereby decreasing the risk of peptic ulcer disease and gastric cancer...
  21. Elucidation of a bacterial cell shape generating program and pathogenic functions
    NINA REDA SALAMA; Fiscal Year: 2013
    ..shaped bacterium that colonizes the human stomach causing clinical outcomes that range from mild gastritis to peptic ulcer and gastric cancers. Most descriptions of H...
  22. Role of Helicobacter Pylori in the Pathogenesis of Childhood Asthma
    Jay V Solnick; Fiscal Year: 2012
    ..pylori commonly infects the human stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. The prevalence of H...
  23. Clinical Development of SQ109 for H. pylori Infection
    LISA BETH FERSTENBERG; Fiscal Year: 2013
    ..1,2 Ten to 20% of H. pylori-infected individuals eventually develop peptic ulcer disease...
  24. Role of H. pylori Outer Membrane Proteins in Colonization and Host Response
    Jay V Solnick; Fiscal Year: 2013
    ..pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. H...
  25. Metal-dependent regulation of the H. pylori Cag type IV secretion system
    Jennifer A Gaddy; Fiscal Year: 2012
    ..Helicobacter pylori is a bacterium that colonizes the human stomach and contributes to gastric cancer and peptic ulcer disease...
  26. Analysis of the H. Pylori cag pathogenicity island
    Timothy L Cover; Fiscal Year: 2012
    ..with the Gram negative bacterium Helicobacter pylori is a risk factor for the development of gastric cancer and peptic ulcer disease. The long-term goals of this work are to understand the molecular mechanisms by which H...
  27. GASTRIC ACID SECRETION AND BUFFER CONTENT AFTER EATING
    Mark Feldman; Fiscal Year: 1991
    ..In most patients, the cause of peptic ulcer disease is unknown although, in general, it is believed to be related to an imbalance between aggressive, ..
  28. Evolution of a bacterial genome encoding increased virulence: the genomics of Hel
    Mark H Forsyth; Fiscal Year: 2012
    ..of the gastric pathogen Helicobacter pylori nearly 30 years ago has drastically altered the treatment of peptic ulcer disease. By means of a horizontally acquired pathogenicity island, the cag PAI, H...
  29. Pathogenesis of Helicobacter pylori infection
    Timothy L Cover; Fiscal Year: 2013
    ..H. pylori infection is associated with an increased risk of cancer of the distal stomach and peptic ulcer disease. In previous studies, we have conducted detailed analyses of a secreted H. pylori toxin (VacA). The H...
  30. HELICOBACTER PYLORI GENOME SEQUENCE EVOLUTION
    DOUGLAS EUGENE BERG; Fiscal Year: 2010
    ..As background, Hp is implicated in peptic ulcer and gastric cancer, although most infections are benign, and some may even be beneficial...
  31. Helicobacter pylori and the gastric microbial community in rhesus macaques
    Jay V Solnick; Fiscal Year: 2010
    ..pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some...
  32. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    Gastric acid secretion is a major factor in causation of GERD and peptic ulcer disease. H. pylori modifies secretion of gastrin and somatostatin and is also a major contributor to ulcerogenesis...
  33. Nanosensor device for the detection of H. Pylori and prevention of gastric cancer
    ANASTASIA RIGAS; Fiscal Year: 2012
    ..a high medical priority because: this bacterium infects approximately 50% of the world's population;causes peptic ulcer disease, gastric cancer, a form of lymphoma (MALToma) and likely several other diseases;and is treatable with ..
  34. Enterotoxigenic Bacteroides fragilis: A bacterial promoter of colon oncogenesis
    CYNTHIA SEARS; Fiscal Year: 2013
    ..Just as the understanding of peptic ulcer disease and ensuing stomach cancer was transformed by the discovery of H...
  35. Host and Bacterial Factors in Disease due to H. pylori
    Kathryn A Eaton; Fiscal Year: 2010
    ..that contribute to disease will be essential for controlling gastritis and the subsequent sequelae such as peptic ulcer disease and cancer...
  36. Transcriptional Control of the Helicobacter pylori RpoN Regulon
    TIMOTHY RANDALL HOOVER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Helicobacter pylori is the causative agent of peptic ulcer disease and a variety of other diseases in humans, including gastric cancer and mucosal-associated lymphoma. Motility is required for H...
  37. CAMPYLOBACTER PYLORIDIS IN GASTRODUODENAL DISEASE
    David Graham; Fiscal Year: 1991
    The presence of C. pyloridis in the stomach has been associated with peptic ulcer disease, non-ulcer dyspepsia and gastritis...
  38. Developing an inactivated whole cell H. pylori vaccine
    GARY NABORS; Fiscal Year: 2006
    ..Clearly a new medical advancement is required to reduce the incidence of peptic ulcer disease and stomach cancer, two conditions caused by infection with H. pylori...
  39. GASTRIC H+ ION TRANSPORT--CELLULAR CONTROL MECHANISMS
    CATHERINE CHEW; Fiscal Year: 1999
    ..b>Peptic ulcer disease is a widespread clinical problem that results from or is exacerbated by gastric acid secretion...
  40. Acetone metabolism in Helicobacter pylori
    Timothy Hoover; Fiscal Year: 2004
    ..that colonizes the gastric mucosa, leading to gastric inflammation that can progress to chronic gastritis, peptic ulcer, gastric cancer or mucosal-associated lymphoma. The ability of H...
  41. DRUG RESISTANCE AND GENE TRANSFER IN H PYLORI
    Douglas Berg; Fiscal Year: 2003
    Helicobacter pylori (HP) is a major cause of peptic ulcer disease and an early risk factor for gastric cancer...
  42. Aspirin, Helicobacter Pylori, and Peptic Ulcer Disease
    Edward Lew; Fiscal Year: 2003
    ..pylori infected patients are at risk for ulcers and GI bleeding while on aspirin. These results may help identify high-risk patients and lead to strategies that will reduce ulcer complications among aspirin users. ..
  43. DOUBLE-BLIND STUDY FOR LONG-TERM OF ULCER HEMORRHAGE
    Dennis Jensen; Fiscal Year: 1992
    ..pylori) infection will cure patients of their chronic peptic ulcer disease and eliminate the risk of recurrent ulcer hemorrhage...
  44. GASTRIC PRENEOPLASIA IN H FELIS INFECTED IL10 MICE
    Daniel Berg; Fiscal Year: 2002
    ..Helicobacter pylori infection is the major etiologic agent of peptic ulcer disease, and chronic H...
  45. MUCOSAL IMMUNOLOGY OF HELICOBACTER INDUCED GASTRITIS
    Steven Czinn; Fiscal Year: 2007
    Helicobacter pylori (H. pylori) is a major cause of chronic active gastritis, primary peptic ulcer disease, and is strongly linked to gastric cancer. Individuals infected with H...
  46. Phenotype MicroArray Analysis of Fastidious Pathogens
    Barry Bochner; Fiscal Year: 2004
    ..I studies proposed here will focus on strains of the gastric pathogen Helicobacter pylori (Hp) (implicated in peptic ulcer disease and gastric cancer), and the intestinal pathogen Campylobacter jejuni (Cj) (a very common cause of ..
  47. ACID INDUCIBLE RESPONSES IN H PYLORI
    Catherine McGowan; Fiscal Year: 2003
    ..superficial gastritis in humans, and this organism plays an important etiologic role in the pathogenesis of peptic ulcer disease and distal gastric adenocarcinoma. H...
  48. WORK SCHEDULES AND HEALTH IN WOMEN HEALTH PROFESSIONALS
    Rosalind Barnett; Fiscal Year: 2001
    ..TMJ, hypertension, coronary artery disease (CAD), peptic ulcer disease (PUD) and nonulcer dyspepsia, and fibromyalgia. Alternative career options (e.g...
  49. Helicobacter Host Interactions in Animal Models
    Stanley Falkow; Fiscal Year: 2009
    ..Infection with the bacterium Helicobacter pylori is causally associated with gastritis and peptic ulcer, as well as gastric adenocarcinoma and gastric lymphoma of mucosa-associated lymphoid tissue (MALT)...
  50. TRANSCRIPTIONAL CONTROL OF GASTRIN
    Juanita L Merchant; Fiscal Year: 2013
    ..origin? RELEVANCE (See instructions): Relevance to publish health include furthering our understanding of peptic ulcer disease, neuroendocrine transformation and the molecular basis underlying the effects of SOM analogs used to ..
  51. LEWIS ANTIGEN EXPRESSION AND PATHOGENESIS OF H PYORI
    JOANNA GOLDBERG; Fiscal Year: 2000
    ..bacterium that lives in the mucus layer of the stomach lining and is the major cause of chronic gastritis and peptic ulcer disease, which is a major risk factor for gastric cancer. The recent realization of the importance of H...
  52. PATHOGENESIS OF H PYLORI INDUCED GASTRIC INFLAMMATION
    Richard Peek; Fiscal Year: 2000
    ..if not most, persons but its high prevalence worldwide results in substantial morbidity and mortality from peptic ulcer disease and gastric cancer...
  53. MECHANISMS OF UREASE SURFACE LOCALIZATION IN H PYLORI
    Bruce Dunn; Fiscal Year: 1999
    ..Helicobacter pylori is a gram-negative bacterium which causes chronic gastritis and plays important roles in peptic ulcer disease, gastric carcinoma and gastric lymphoma...
  54. IDENT OF H PYLORI VIRUL FACTORS IN ETHNIC POPULATIONS
    David Graham; Fiscal Year: 2000
    ..pylori (Hp) is a common worldwide infection; it is now known to be etiologically related to gastritis, peptic ulcer disease, gastric adenocarcinoma, and primary gastric lymphoma...
  55. IMMUNOPATHOGENESIS OF H PYLORI INFECTION
    Geraldine Miller; Fiscal Year: 1999
    ..both host inflammatory responses and genetic characteristics of the infecting organisms differ in patients with peptic ulcer disease versus those with gastritis alone...
  56. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2005
    ..pylori causes a histological gastritis that in some individuals is associated with the development of peptic ulcer disease or gastric malignancy. Although H...
  57. Differential Transcription Factor Activation by H. pylor
    Duane Smoot; Fiscal Year: 2006
    ..pylori) infection has greatly changed our understanding of upper G.I. tract diseases, including peptic ulcer disease and stomach cancer. The world health organization has classified H. pylori as a group one carcinogen...
  58. NOVEL PROTEIN KINASE IN DIGESTIVE ENZYME SECRETION
    Laura Tang; Fiscal Year: 1999
    ..gastrointestinal tract and is considered to contribute to pathological processes such as reflux esophagitis, peptic ulcer disease and pancreatitis...
  59. Heat Shock Proteins and Helicobacter Pylori Pathogenesis
    Evelyn Kurt Jones; Fiscal Year: 2006
    Helicobacter pylori infection causes gastritis, peptic ulcer disease, gastric atrophy and gastric cancer. The World Health Organization has classified H. pylori as a Class I carcinogen. In animal models, the progression of H...
  60. EPITHELIAL H+ TRANSPORT--STRUCTURE OF H,K-ATPASE
    Adam Smolka; Fiscal Year: 2000
    ..One motivation is the world-wide prevalence of peptic ulcer disease and the relationship between ulcer pathophysiology and acid secretion; equally important is ..
  61. H. PYLORI BREATH TEST WITH INFRARED SPECTRAL DETECTION
    RONALD MICHEELS; Fiscal Year: 2000
    ..pylori, an organism that colonizes the mucus gel layer of the gastric antrum, is associated with recurrent peptic ulcer disease and gastric malignancies. One of the preferred methods for diagnosis of H...
  62. PREVENTION/TREATMENT OF H. PYLORI WITH LACTOFERRIN
    BRUCE SCHRODER; Fiscal Year: 2001
    ..Scanned from the applicant's description) An estimated 25 million persons in the United States have had peptic ulcer disease during their lifetimes...
  63. Global Scanning for Resistance Mutations in H.pylori
    Sherman Weissman; Fiscal Year: 2004
    Helicobacter pylori (Hp) is a major cause of peptic ulcer disease and an early risk factor for gastric cancer...