Genomes and Genes
Summary: Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON.
Publications206 found, 100 shown here
- [Ulcerations in Chagas' megacolon operated at urgency and electively]Augusto Diogo-Filho
Departamento de Cirurgia, Universidade Federal de Uberlandia, MG
Arq Gastroenterol 43:280-3. 2006corrected] The megacolon is a frequent disease in our emergencie hospital, and approached in the urgency by your complications as fecal impaction, volvulus and perforations...
- Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cellsAlexandre Barcelos Morais da Silveira
Department of Morphology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, CEP 31270 901 Pampulha, Belo Horizonte, Minas Gerais, Brazil
Hum Pathol 38:1256-64. 2007..the Chagas disease parasite, Trypanosoma cruzi, some patients who are serologically positive develop chronic megacolon and megaesophagus, whereas others are symptom-free...
- Association of megacolon with two recessive spotting genes in the mouseP W Lane
J Hered 57:29-31. 1966
- A case of megacolon in Rio Grande valley as a possible case of Chagas diseaseKarl Reinhard
School of Natural Resource Sciences, 214 Bessey Hall, University of Nebraska Lincoln, Lincoln, NE 68588 0340, USA
Mem Inst Oswaldo Cruz 98:165-72. 2003..Specifically, we have looked for evidence of alteration of intestinal or fecal morphology consistent with megacolon, a condition associated with Chagas disease...
- The enteric nervous system in chagasic and idiopathic megacolonGuido Iantorno
Digestive Motility Section, Dr C B Udaondo Hospital, Buenos Aires, Argentina
Am J Surg Pathol 31:460-8. 2007Chagas disease frequently causes megacolon. We investigated the enteric nervous systems in patients with chagasic megacolon compared to idiopathic megacolon and controls...
- Morphometric study of eosinophils, mast cells, macrophages and fibrosis in the colon of chronic chagasic patients with and without megacolonA B M da Silveira
Department of Morphology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
Parasitology 134:789-96. 2007The mechanisms involved in the pathogenesis of chagasic megacolon are not completely characterized...
- Embryogenesis of the enteric ganglia in normal mice and in mice that develop congenital aganglionic megacolonW Webster
J Embryol Exp Morphol 30:573-85. 1973
- Phenotypic alteration of interstitial cells of Cajal in idiopathic sigmoid megacolonYasushi Adachi
Internal Medicine, Sapporo Shirakabadai Hospital, 2 18 Higashi Tsukisamu, Sapporo, 062 0052, Japan
J Gastroenterol 43:626-31. 2008..This study was performed to clarify the role of ICCs in idiopathic sigmoid megacolon using histological and immunohistochemical examinations.
- Preponderance of inhibitory versus excitatory intramuscular nerve fibres in human chagasic megacolonSamir Jabari
Institute of Anatomy I, University of Erlangen Nuremberg, Erlangen, Germany
Int J Colorectal Dis 27:1181-9. 2012b>Megacolon, chronic dilation of a colonic segment, is a frequent sign of Chagas disease. It is accompanied by an extensive neuron loss which, as shown recently, results in a partial, selective survival of nitrergic myenteric neurons...
- The significantly reduced number of interstitial cells of Cajal in chagasic megacolon (CM) patients might contribute to the pathophysiology of CMSheila Jorge Adad
Discipline of Special Pathology, Universidade Federal do Triangulo Mineiro, Av Getùlio Guaritá, 130, CEP 38025 440 Uberaba, MG, Brazil
Virchows Arch 461:385-92. 2012..neurons, and muscular area, the latter to correct for quantitation errors resulting from dilation in case of a megacolon and from the dispersion of ICC that can be attributed to muscular hypertrophy...
- Chagasic megacolon associated with Trypanosoma cruzi I in a Colombian patientOscar Flórez
Grupo de Inmunología y Epidemiología Molecular, GIEM, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia
Parasitol Res 107:439-42. 2010Chagasic megacolon has been reported in the southern cone countries of South America and is mainly associated with Trypanosoma cruzi II infection...
- Partial, selective survival of nitrergic neurons in chagasic megacolonSamir Jabari
Institute of Anatomy I, University of Erlangen Nuremberg, Krankenhausstr 9, 91054, Erlangen, Germany
Histochem Cell Biol 135:47-57. 2011One frequent chronic syndrome of Chagas' disease is megacolon, an irreversible dilation of a colonic segment. Extensive enteric neuron loss in the affected segment is regarded as key factor for deficient motility...
- Morphometric study of the fibrosis and mast cell count in the circular colon musculature of chronic Chagas patients with and without megacolonSimone Wanderley Pinheiro
Faculdade de Medicina do Triangulo Mineiro, Uberaba, MG, Brasil
Rev Soc Bras Med Trop 36:461-6. 2003..The objective was to gain better understanding of Chagas megacolon morphology and contribute towards the knowledge of fibrosis pathogenesis in Chagas megas...
- Comparison of biofragmentable anastomosis ring and sutured anastomoses for subtotal colectomy in cats with idiopathic megacolonStewart Ryan
Colorado State University Veterinary Medical Center, Fort Collins, CO, USA
Vet Surg 35:740-8. 2006To report use of a biofragmentable anastomosis ring (BAR) device in cats with idiopathic megacolon (FIM) and compare outcome after subtotal colectomy with sutured colocolic anastomosis.
- Recurrent cytomegalovirus colitis with megacolon in an immunocompetent elderly manYi Hsuan Lin
Division of Digestive Therapeutic Endoscopy, Department of Gastroenterology, Chang Gung Memorial Hospital, Linkou Medical Center, Tao Yuan, Taiwan
J Med Virol 82:638-41. 2010..by poor improvement of his symptoms after the CMV infection was treated with ganciclovir, and the occurrence of megacolon. A repeat colonoscopy with biopsy revealed a recurrence of the CMV infection...
- Association of chagasic megacolon and cancer of the colon: case report and review of the literatureSheila Jorge Adad
Disciplina de Patologia Especial, Faculdade de Medicina do Triangulo Mineiro, Uberaba, MG, Brazil
Rev Soc Bras Med Trop 35:63-8. 2002There are few descriptions of association between chagasic megacolon and colon cancer. We report a case of obstructive abdomen caused by adenocarcinoma of the left colon in chagasic megacolon...
- Neuron count reevaluation in the myenteric plexus of chagasic megacolon after morphometric neuron analysisS J Adad
Discipline of Special Pathology, Patologia Especial Hospital Escola Faculdade de Medicina do Triângulo Mineiro, Rua Getúlio Guaritá 130, Uberaba MG, 38025 440, Brazil
Virchows Arch 438:254-8. 2001..measured on paraffin sections in a ring from the sigmoid in Chagas' disease patients, 17 with and 10 without megacolon and in 10 non-chagasic controls. All neurons were counted in ten en-echelon sections...
- Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patientsGerd Wallukat
Max Delbrück Centrum Berlin, Berlin, Germany
J Am Coll Cardiol 55:463-8. 2010..the patterns of autoantibodies (AAB) against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon and the discovery of such a pattern in patients who are as yet asymptomatic could help to identify patients at ..
- Targeted expression of SV40 large T-antigen to visceral smooth muscle induces proliferation of contractile smooth muscle cells and results in megacolonB P Herring
Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
J Biol Chem 274:17725-32. 1999..These transgenic mice thus represent a novel model of megacolon that results from increased smooth muscle cell proliferation rather than altered neuronal innervation.
- Neurochemical coding of the enteric nervous system in chagasic patients with megacolonA B M da Silveira
Department of Morphology, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antônio Carlos 627, Pampulha, Belo Horizonte, Minas Gerais, CEP, 31270 901, Brazil
Dig Dis Sci 52:2877-83. 2007Neuronal destruction has been considered the hallmark of pathogenic mechanisms in chagasic megacolon. Characterization of neuropeptides in the enteric nervous system from chagasic patients with megacolon could elucidate some aspects of ..
- A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient miceM Hatano
Division of Developmental Genetics, Chiba University School of Medicine, Chiba 260, Japan
J Clin Invest 100:795-801. 1997..The homozygous mutant mice were viable. These mice developed megacolon with enteric ganglia by age 3-5 wk...
- Giant fecaloma with idiopathic sigmoid megacolon: report of a case and review of the literatureAmbil Rajagopal
Department of Surgery, PSG Institute of Medical Sciences and Research, Coimbatore, India
Dis Colon Rectum 45:833-5. 2002..This is a report of a giant, solitary, and stubborn fecaloma not responding to nonoperative management. A surgical intervention for uncomplicated fecal impaction is rarely needed and reported in the literature...
- Surgical treatment of Chagas megacolon. Critical analysis of outcome in operative methodsRicardo Luiz Santos Garcia
Division of Coloproctology, Department of Surgery and Anatomy, Ribeirao Preto Faculty of Medicine, University of Sao Paulo, SP, Brazil
Acta Cir Bras 23:83-92; discussion 92. 2008Surgical treatment of chagasic megacolon has suffered innumerable transformations over the years. Poor knowledge of the disease physiopathology is one of the reasons.
- Prevalence of rectoanal inhibitory reflex in chagasic megacolonSimone Cavenaghi
Service of Physiotherapy, Department of Neurological Sciences, Hospital de Base, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil
Arq Gastroenterol 45:128-31. 2008Rectoanal inhibitory reflex is not always evident in patients with chagasic megacolon. This may be due to insufficient volumes of air used during insufflation for the manometric examination.
- Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolonThilo Wedel
Department of Anatomy, Medical Universitiy of Luebeck, Luebeck, Germany
Gastroenterology 123:1459-67. 2002..This study evaluates both the distribution of interstitial cells of Cajal and the pathohistology of the enteric nervous system in 2 severe human colorectal motility disorders...
- Total proctocolectomy and ileal J-pouch anal anastomosis for chagasic megacolon with fecaloma: report of a caseToshimitsu Araki
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, 514 8507, Japan
Surg Today 36:277-9. 2006b>Megacolon, resulting in severe constipation, is one of the most common manifestations of Chagas' disease. We herein report a case of megacolon with fecaloma in a 39-year-old Brazilian man who presented with severe constipation...
- Trypanosoma cruzi: typing of genotype (sub)lineages in megacolon samples from bolivian patientsMyrna Virreira
Laboratoire de Chimie Biologique, Faculte de Medecine, Universite Libre De Bruxelles U L B, Brussels, Belgium
Acta Trop 100:252-5. 2006..distributed evenly, therefore, we investigated the possible relationship between parasite (sub)lineages in megacolon patients. We typified the T...
- Cell-mediated immune response in megacolon from patients with chronic Chagas' diseaseC E Corbett
Department of Pathology, School of Medicine, , Av. Dr. Amaldo 455, , Brazil
Dis Colon Rectum 44:993-8. 2001..that control chronic infection in vivo and the immunologic mechanisms involved in the pathogenesis of chagasic megacolon are not completely characterized...
- Megacolon and stercoral proctitis after frequent fecal impactions: report of an unusual case and review of the literatureJen Tzer Gau
Department of Geriatric Medicine Gerontology, College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA
J Am Med Dir Assoc 8:338-41. 2007Persistent megacolon that results from frequent episodes of fecal impaction without adequate treatment is a rare and seldom reported condition in the elderly...
- Characterization of the presence and distribution of Foxp3(+) cells in chagasic patients with and without megacolonAlexandre B M da Silveira
Biomedical Institut Sciences, Universidade Federal de Uberlandia, Brazil
Hum Immunol 70:65-7. 2009Patients with Chagas's disease in the chronic phase regularly present with the chagasic megacolon. This form is characterized by inflammation, neuronal destruction, and organ dilatation...
- Substance P and NK1 receptor expression in the enteric nervous system is related to the development of chagasic megacolonAlexandre B M da Silveira
Research Center Rene Rachou, FIOCRUZ, Av Augusto de Lima, 1715, Barro Preto, Belo Horizonte, MG, Brazil
Trans R Soc Trop Med Hyg 102:1154-6. 2008Chagasic megacolon is one of the most important forms of Chagas disease. This form is characterized by inflammation, neuronal destruction and organ dilatation...
- Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolonS Shirasawa
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nat Med 3:646-50. 1997..Enx-deficient mice develop megacolon with massive distension of the proximal colon...
- Strategy for the surgical management of patients with idiopathic megarectum and megacolonC B O Súilleabháin
Department of Coloproctology, Royal Infirmary, Glasgow G32 2ER, UK
Br J Surg 88:1392-6. 2001..Several surgical procedures have been used to treat idiopathic megabowel. A structured approach to the surgical management of megarectum/colon is reported...
- Systematic review of surgical options for idiopathic megarectum and megacolonMarc A Gladman
Centre for Academic Surgery Gastrointestinal Physiology Unit, Barts, London, UK
Ann Surg 241:562-74. 2005..The aim of this systematic review was to evaluate the published outcome data of surgical procedures for IMB in adults...
- Transverse to descending colon volvulus and megacolon with mesenterium commune: report of a caseSatoru Tobinaga
Department of Surgery, Chikugo City Hospital, Fukuoka, Japan
Surg Today 34:875-7. 2004We report a case of volvulus of the transverse-descending (T-D) colon and megacolon associated with mesenterium commune. A 70-year-old man was referred to our hospital for investigation of severe constipation and abdominal fullness...
- The usefulness of ultrasound examination of the bowel as a method of assessment of functional chronic constipation in childrenArtur Bijoś
Medical Faculty, University of Rzeszow, Warszawska 26a, Rzeszow, Poland
Pediatr Radiol 37:1247-52. 2007..Ultrasonographic assessment of stool retention in children with chronic constipation requires the diagnosis of megarectum...
- [Cystic mass of the pancreatic region associated with elevated CA 19-9 serum levels revealing a colonic duplication in an adult]Jean Rémy Legros
Service de Chirurgie Generale et Digestive, Hopital Charles Nicolle, Rouen
Gastroenterol Clin Biol 28:1291-3. 2004..Although the physiopathology of the expression of CA 19-9 in duplications is unclear, this feature has been recently reported in adults and could be of interest in the diagnosis and management of intestinal duplications...
- Persistent obstructive symptoms after surgery for Hirschsprung's disease: development of a diagnostic and therapeutic algorithmJacob C Langer
University of Toronto and Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Surg 39:1458-62. 2004..The author's goal was to develop an organized algorithm for the workup and ultimate management of these symptoms...
- Surgical treatment of chagasic megacolon: Duhamel-Haddad procedure is also a good optionFabio V Teixeira
Dis Colon Rectum 46:1576; author reply 1577-8. 2003
- Multimedia article. Laparoscopic-assisted rectosigmoidectomy with ileal loop interposition. Surgical treatment of chagasic megacolonEloy Espin-Basany
Colorectal Surgery Unit, Hospital Valle de Hebron, Autonomous University of Barcelona, Barcelona, Spain
Dis Colon Rectum 51:1421. 2008Chagas disease is a frequent cause of acquired megacolon in several countries of Latin America. Several procedures have been described to treat this condition...
- [Gastrointestinal motility disturbances in Chagas disease]Ana Maria Madrid
Servicio de Medicina, Sección de Gastroenterología, Hospital Clinico de la Universidad de Chile, Santiago, Chile
Rev Med Chil 132:939-46. 2004..Chagas disease is rarely an aetiological factor for achalasia in Chile, which is different from reports in other countries of South America. In contrast, a high incidence of megacolon among these patients have been reported.
- [Megarectum and anismus: a cause of constipation]Y Real Martínez
Servicio de Aparato Digestivo, Hospital Virgen de la Torre, Madrid
Rev Esp Enferm Dig 99:352-3. 2007
- The different concentrations of mast cells in the musculature of the esophagus and the colonSimone Wanderley Pinheiro
Hum Pathol 39:793; author reply 793. 2008
- Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolonJung Il Lee
Department of Internal Medicine, Inha University of Medicine, Incheon, Seoul, Korea
J Gastroenterol Hepatol 20:1292-8. 2005..The aims of the present study were to assess the distribution of ICC and neuronal cells of ENS in patients with slow-transit constipation and acquired megacolon.
- [Features of Chagas' disease patients with emphasis on digestive form, in a tertiary hospital of Ribeirão Preto, SP]Mayra Mayumi Kamiji
Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, R Fiorígio Casilo 48 22, Santa Cruz, 14020 685 Ribeirão Preto, Sao Paulo, Brazil
Rev Soc Bras Med Trop 38:305-9. 2005..Median age was 67 years and 210 (56%) were women. Megaesophagus and/or megacolon were present in 135 patients, 59% of these had cardiopathy...
- Recurrence of chagasic megacolon after surgical treatment: clinical, radiological, and functional evaluationSergio Eduardo Alonso Araujo
Clinics (Sao Paulo) 62:89-92. 2007
- Pre-Columbian Chagas disease in Brazil: Trypanosoma cruzi I in the archaeological remains of a human in Peruaçu Valley, Minas Gerais, BrazilAlexandre Fernandes
Laboratório de Genética Molecular de Microorganismos, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brasil
Mem Inst Oswaldo Cruz 103:514-6. 2008We evaluated the presence and distribution of Trypanosoma cruzi DNA in a mummy presenting with megacolon that was dated as approximately 560 +/- 40 years old. The mummy was from the Peruaçu Valley in the state of Minas Gerais, Brazil...
- Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon developmentA B M da Silveira
Research Center Rene Rachou, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
Parasitology 135:1337-42. 2008..However, some pathological aspects of the chagasic megasyndromes are still incompletely understood. Chagasic megacolon is characterized by an inflammatory process, organ dilatation and neuronal reduction in both plexuses of the ..
- Multiple clinical presentations of anal ultra slow waves and high anal pressure: megacolon, hemorrhoids and constipationHiroaki Yoshino
Department of Pediatric Surgery, Akita University School of Medicine, Japan
Tohoku J Exp Med 211:127-32. 2007..In the manometric studies of the patients with severe chronic constipation, we noticed that some patients with megacolon show very slow periodical (< 2/min) pressure change in the anal canal, namely ultra slow waves (USWs)...
- [Hypoganglionosis as a cause of chronic constipation]E Bruder
Institut fur Pathologie, Universitatsspital Basel, Schonbeinstrasse 40, 4031 Basel, Switzerland
Pathologe 28:131-6. 2007..Similar to Hirschsprung's disease, hypoganglionosis may be complicated by megacolon formation and must be considered in the differential diagnosis...
- [Effect of combined drug treatment on megacolon with severe constipation]Zhao lu Ding
Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Zhonghua Yi Xue Za Zhi 87:670-2. 2007To assess the effectiveness of combined drug treatment on megacolon complicated by severe constipation.
- Decreased expression of IK channels in neurons from enteric nervous system is associated with the development of chagasic megacolonAlexandre B M da Silveira
Hum Pathol 39:1406-7. 2008
- The pathogenesis of idiopathic megacolonWilliam A Meier-Ruge
Department of Pathology, University Medical School, Basel, Switzerland
Eur J Gastroenterol Hepatol 18:1209-15. 2006Even today, the pathogenesis of idiopathic megacolon is still a subject of controversy. Anomalies of the gastrointestinal autonomous nervous system or of the smooth muscle of the muscularis propria are being considered.
- Adult Hirschsprung's disease diagnosed during forensic autopsyDenis Chatelain
Department of Pathology, centre hospitalier universitaire d Amiens, Place Victor Pauchet, 80054 Amiens cedex 01, France
J Forensic Sci 51:1160-3. 2006..He had a past history of chronic constipation since infancy. Forensic autopsy revealed a megacolon full of gas and stools...
- Surgical treatment of Chagasic megacolon by abdominal rectosigmoidectomy with immediate posterior end-to-side stapling (Habr-Gama technique)Sergio C Nahas
Department of Gastroenterology, Colorectal Surgery Division, University of Sao Paulo, School of Medicine, Rua Jabebira 136, 05602 020 São Paulo, SP, Brazil
Dis Colon Rectum 49:1371-8. 2006Various techniques have been used in the surgical treatment of Chagasic megacolon, including sympathectomy, sphincterotomy, anterior abdominal resection with high or low anastomosis, pull-through procedures, and Duhamel technique...
- [Disturbances of small intestinal motility in patients with chronic constipation]Ana Maria Madrid
Sección de Gastroenterología, Departamento de Medicina, Hospital Clinico, Universidad de Chile, Santiago, Chile
Rev Med Chil 134:181-6. 2006..Studies in patients with chronic severe constipation, suggest the presence of a diffuse motor disorder of the gastrointestinal tract...
- Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix productionMattias Ormestad
Department of Cell and Molecular Biology, Goteborg University, Goteborg, Sweden
Development 133:833-43. 2006..Inactivation of both Foxf2 alleles, or one allele each of Foxf1 and Foxf2, cause a range of defects, including megacolon, colorectal muscle hypoplasia and agangliosis...
- Idiopathic megacolonFrank Autschbach
University Heidelberg, Institute of Pathology, Heidelberg, Germany
Eur J Gastroenterol Hepatol 19:399-400. 2007..The pathogenesis of idiopathic megacolon. Eur J Gastroenterol Hepatol 2006; 18:1209-1215...
- Strategy for the surgical management of patients with idiopathic megarectum and megacolon (Br J Surg 2001;88:1392-6)M A Gladman
Br J Surg 89:623. 2002
- Interaction of human chagasic IgG with human colon muscarinic acetylcholine receptor: molecular and functional evidenceL Sterin-Borda
Pharmacology Unit, School of Medicine and Dentistry, University of Buenos Aires, Argentina
Gut 49:699-705. 2001..The pathogenesis seems to be associated with autonomic dysfunction. Here, we consider the muscarinic cholinoceptor mediated alteration in distal colon function in chagasic megacolon.
- [Differential surgical treatment of idiopathic megadolichocolon in adults]V M Bensman
Vestn Khir Im I I Grek 161:33-7. 2002..A new operation--endofascial resection of the rectum--is proposed for treatment of proctogenic SCC. The differential surgical strategy with pathomorphogenesis of SCC taken into account allowed to get satisfactory results in 73% of cases...
- Idiopathic slow transit constipation and megacolon are not associated with neurturin mutationsB Chen
Department of Paediatric Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
Neurogastroenterol Motil 14:513-7. 2002Chronic idiopathic slow-transit constipation (ISTC) and idiopathic megacolon (IMC) are early-onset gastrointestinal motility disorders of unknown aetiology...
- Fetal development of the enteric nervous system of transgenic mice that overexpress the Hoxa-4 geneV M Tennyson
Department of Anatomy, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Dev Dyn 211:269-91. 1998b>Megacolon occurs in neonatal and adult transgenic mice that overexpress the Hoxa-4 gene...
- Histologic criteria for the diagnosis of allied diseases of Hirschsprung's disease in adultsK Munakata
First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan
Eur J Pediatr Surg 12:186-91. 2002....
- Morphologic and morphometric evaluation of pancreatic islets in chronic Chagas' diseaseJ C Saldanha
Department of Pathology, Faculty of Medicine, Triangulo, Mineiro
Rev Hosp Clin Fac Med Sao Paulo 56:131-8. 2001..CONCLUSION: The observed morphometric and morphologic alterations are consistent with functional changes in the pancreas, including glycemia and insulin disturbances...
- Constipation and megacolon in rats related to treatment with oxodipine, a calcium antagonistA Nyska
Kimron Veterinary Institute, Beit Dagan, Israel
Toxicol Pathol 22:589-94. 1994..This paper reports the occurrence of megacolon in rats as a result of the constipatory effects of chronic administration of oxodipine...
- Surgical management of constipationR N White
Davies White Veterinary Specialists, Higham Gobion, Hitchin, Hertfordshire
J Feline Med Surg 4:129-38. 2002..Most surgery therapies for constipation in the cat are related to the management of idiopathic megacolon, although causes such as pelvic outlet obstruction, complications of neutering surgery, perineal herniation, and ..
- Recurrent sigmoid volvulus in a sixteen-year-old boy: case report and review of the literatureMimi N Ton
Division of Gastroenterology and Nutrition, Children s Hospital of New York, Columbia University, New York, NY 10032, USA
J Pediatr Surg 39:1434-6. 2004..Several months after surgery, he remains free of symptoms and is doing well. A review of the literature illustrates the approach to this problem from ancient times until now...
- Distribution and development of peptidergic nerves and gut endocrine cells in mice with congenital aganglionic colon, and their normal littermatesC Vaillant
Gastroenterology 82:291-300. 1982..Thus the findings of normal populations of gut endocrine cells in the aganglionic segment is further support for the view that the embryologic origin of gut endocrine cells is different to that of gut neurons...
- Simultaneous decompression colonoscopy and radiologic G-tube insertion in a patient with megacolon because of chronic colonic pseudo-obstructionAlain Attar
Hopital Avicenne, Bobigny
Gastrointest Endosc 62:975-6; discussion 976. 2005
- Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized studyT Arvola
Medical School, University of Tampere and the Department of Pediatrics, Tampere University Hospital, Tampere, Finland
Pediatrics 104:e64. 1999..diarrhea with electrolyte disturbances, dehydration, crampy abdominal pain, pseudomembranous colitis, toxic megacolon, or even death. The incidence of diarrhea in children receiving a single antimicrobial treatment is unclear...
- Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)Jose A Castro
Centro de Investigaciones Toxicológicas CEITOX CITEFA CONICET, J B de La Salle 4397, Villa Martelli, Pcia de Buenos Aires 1603, Argentina
Hum Exp Toxicol 25:471-9. 2006..of the survivors develop chronic Chagas' disease, which is characterized by potentially lethal cardiopathy and megacolon or megaoesophagus...
- Structural abnormalities associated with congenital megacolon in transgenic mice that overexpress the Hoxa-4 geneV M Tennyson
Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032
Dev Dyn 198:28-53. 1993Congenital megacolon develops in transgenic mice that overexpress the homeobox-containing gene, Hoxa-4. The current study was done to identify abnormalities of the terminal colon that might account for the phenotype...
- Clinical features of Clostridium difficile-associated infections and molecular characterization of strains: results of a retrospective study, 2000-2004Frederic Barbut
Service de Microbiologie, Hopital Saint Antoine, Paris, 75012, France
Infect Control Hosp Epidemiol 28:131-9. 2007..Recent outbreaks of severe cases of Clostridium difficile-associated diarrhea (CDAD) reported in North America, the United Kingdom, and The Netherlands have emphasized the importance of an ongoing epidemiological surveillance of CDAD...
- Outcome following emergency surgery for refractory severe ulcerative colitis in a tertiary care centre in IndiaSujoy Pal
Department of GI Surgery and Liver Transplantation, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
BMC Gastroenterol 5:39. 2005....
- Life-threatening clozapine-induced gastrointestinal hypomotility: an analysis of 102 casesSusanna E Palmer
Te Korowai Whariki Mental Health Services, Capital and Coast District Health Board, Wellington, New Zealand
J Clin Psychiatry 69:759-68. 2008..To raise awareness of potentially lethal clozapine-induced gastrointestinal hypomotility (CIGH) by reviewing cases from the literature and unpublished pharmacovigilance data and to offer strategies aimed at prevention and early treatment...
- Lineage analysis of circulating Trypanosoma cruzi parasites and their association with clinical forms of Chagas disease in BoliviaRamona del Puerto
Department of Immunogenetics, Institute of Tropical Medicine NEKKEN, Nagasaki University, Nagasaki, Japan
PLoS Negl Trop Dis 4:e687. 2010..blood samples from three different clinical groups of chronic Chagas disease patients (indeterminate, cardiac, megacolon) from Bolivia were analyzed for their circulating parasites lineages using minicircle kinetoplast DNA ..
- Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activitySeungil Ro
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, 89557, USA
Am J Physiol Gastrointest Liver Physiol 290:G710-8. 2006It has been assumed that in piebald lethal mice that develop megacolon, impaired colonic motor activity is restricted to the aganglionic distal colon...
- [The development of a toxic megacolon due to Amanita phalloides poisoning. A rare complication]F Eyer
Toxikologische Abteilung der II Medizinischen Klinik, Klinikum rechts der Isar Technische Universität München, Munchen, Germany
Dtsch Med Wochenschr 129:137-40. 2004..Other than a transient tachycardia and diffuse pain on abdominal palpation clinical examination was without abnormal findings...
- Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severityJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Que
CMAJ 171:466-72. 2004..difficile-associated diarrhea (CDAD) in our institution. We describe cases of CDAD at our institution over a 13-year period and investigate changes in illness severity...
- Augmented unilateral gluteoplasty with fascia lata graft in fecal incontinenceM Farid
Colorectal Surgery Unit, Mansoura University Hospital, P O Box 324, Mansoura, Egypt
Tech Coloproctol 7:23-8; discussion 28. 2003..This study was undertaken to evaluate the results of augmented unilateral gluteoplasty with fascia lata graft in patients with fecal incontinence due to congenital or neurologic disorders...
- Characterization of clinical Clostridium difficile isolates by PCR ribotyping and detection of toxin genes in Austria, 2006-2007A Indra
Austrian Agency for Health and Food Safety AGES, Waeringerstrasse 25a, A 1090 Vienna, Austria
J Med Microbiol 57:702-8. 2008..7%), as pseudomembranous colitis in 15 cases (10.6%) and as toxic megacolon in one case. Twelve of the 142 patients died within 30 days of specimen collection (8.45% lethality)...
- Defining surgical therapy for pseudomembranous colitis with toxic megacolonLoren Berman
Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
J Clin Gastroenterol 42:476-80. 2008Pseudomembranous colitis has increased in incidence and severity over the past 10 years. Toxic megacolon is a rare but reported presentation of severe pseudomembranous colitis...
- Clostridium difficile associated infection, diarrhea and colitisPerry Hookman
University of Miami Miller School of Medicine, Division of Gastroenterology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
World J Gastroenterol 15:1554-80. 2009..Before 2002, toxic megacolon in C. difficile-associated colitis (CDAC), was rare, but its incidence has increased dramatically...
- [Long-term outcomes of ileal pouch after secondary diagnosis of Crohn's disease]Maria de Lourdes Setsuko Ayrizono
Grupo de Coloproctologia, Departamento de Cirurgia e Departamento de Anatomia Patológica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Sao Paulo, SP, Brazil
Arq Gastroenterol 45:204-7. 2008..Total rectocolectomy and ileal pouch-anal anastomosis is the choice surgical procedure for patients with ulcerative colitis. In cases of Crohn's disease post-operative diagnosis, it can be followed by pouch failure...
- The thyroid and the gutEllen C Ebert
Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
J Clin Gastroenterol 44:402-6. 2010..Constipation may result from diminished motility, leading to an ileus, megacolon, or rarely pseudoobstruction. Ascites in myxedema is characterized by a high protein concentration...
- An unusual case of an ulcerative colitis flare resulting in disseminated intravascular coagulopathy and a bladder hematoma: a case reportDavid L Suskind
Department of Pediatrics, Seattle Children s Hospital and Regional Medical Center, University of Washington, 4800 Sand Point Way NE, Seattle, Washington, USA
BMC Gastroenterol 4:26. 2004..Ulcerative colitis has been associated with disseminated intravascular coagulation in conjunction with septicemia, toxic megacolon and surgery.
- Chronic constipation - the role of clinical assessment and colorectal physiologic tests to obtain an etiologic diagnosisAntônio Lacerda-Filho
Alfa Institute of Gastroenterology, Federal University of Minas Gerais Medical School, Belo Horizonte, MG, Brazil
Arq Gastroenterol 45:50-7. 2008..Although colorectal physiologic tests have brought an important contribution, it remains unclear in which patients these tests should be indicated for...
- [Role of fetal urine sampling in the prenatal diagnosis of malformative uropathies]Christophe Lopez
Service d Urologie II, CHU Lapeyronie, Montpellier, France
Prog Urol 12:1261-7. 2002..To define the diagnostic and therapeutic value of foetal urine sampling (FUS)...
- Current indications for blow-hole colostomy:ileostomy procedure. A single center experienceFeza H Remzi
Department of Colorectal Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195 USA
Int J Colorectal Dis 18:361-4. 2003..blow-hole colostomy with loop ileostomy is now rarely performed to reduce operative risks in patients with toxic megacolon related to inflammatory bowel disease (IBD)...
- The rapid growth of intraluminal tumor metastases at the intestinal wall sites damaged by obstructive colitis due to sigmoid colon cancer: report of a caseEiji Mekata
Department of Surgery, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Shiga, 520 2192, Japan
Surg Today 38:862-5. 2008A 53-year-old woman who was traveling in Australia was admitted to a local hospital with pyrexia and diarrhea. Megacolon was diagnosed from an X-ray and an emergency operation was performed...
- [The Latin-American Consensus on Chronic Constipation]Max Schmulson Wasserman
Laboratorio de Hígado, Páncreas y Motilidad HIPAM Departamento de Medicina Experimental Facultad de Medicina Universidad Nacional Autónoma de México UNAM Hospital General de México México
Gastroenterol Hepatol 31:59-74. 2008..barium enema as an initial investigation was recommended only in countries with a high prevalence of idiopathic megacolon or Chagas' disease...
- Toxic megacolon in Salmonella colitis: report of two casesM M Tiao
Department of Pediatrics, Chang Gung Children s Hospital, Kaohsiung, Taiwan
Acta Paediatr Taiwan 41:43-6. 2000Toxic megacolon is a complication that usually presents in inflammatory bowel disease such as ulcerative colitis or Crohn's disease...
- A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infectionPatricia S Doyle
Department of Pathology, University of California San Francisco, CA 94121, USA
Antimicrob Agents Chemother 51:3932-9. 2007..derive from infection of muscle cells leading to progressive cardiomyopathy, while some patients develop megacolon or megaesophagus...
- Clinical severity of Clostridium difficile PCR ribotype 027: a case-case studyOliver W Morgan
East of England Regional Epidemiology Unit, Health Protection Agency, Cambridge, United Kingdom
PLoS ONE 3:e1812. 2008..Several industrialised countries have reported increased C. difficile infections and outbreaks, which have been attributed to the emergent PCR ribotype 027 strain...
- Acute and chronic megacolonStephen B Hanauer
Arnold Wald, MD Section of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, H6 516 CSC, Madison, WI 53792 5124, USA
Curr Treat Options Gastroenterol 10:237-47. 2007b>Megacolon, defined as dilation of the abdominal colon, may occur acutely or in a chronic form...
- Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec, CanadaJacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Quebec, Canada
Clin Infect Dis 42:758-64. 2006....
- Non-toxic megacolon due to transverse and sigmoid colon volvulus in a patient with ulcerative colitisKonstantinos Katsanos
1st Department of Internal Medicine and Hepato Gastroenterology Unit, Medical School, University of Ioannina, 451 10 Ioannina, Greece
J Crohns Colitis 3:38-41. 2009..2 g/dl and C-reactive protein at 310 mg/dl. Radiology was suggestive of megacolon and volvulus...
- Recommendations for surveillance of Clostridium difficile-associated diseaseL Clifford McDonald
Centers for Disease Control and Prevention, Atlanta, GA, USA
Infect Control Hosp Epidemiol 28:140-5. 2007..However, the understanding of the magnitude of and reasons for this change is currently hampered by the lack of standardized surveillance methods...
- Factors associated with intestinal perforation in children's non-typhi Salmonella toxic megacolonH C Chao
Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
Pediatr Infect Dis J 19:1158-62. 2000To evaluate the risk factors for intestinal perforation in children with toxic megacolon caused by non-typhi Salmonella infection.
- Impaired growth and differentiation of diploid but not immortal melanoblasts from endothelin receptor B mutant (piebald) miceE V Sviderskaya
St George s Hospital Medical School, London, United Kingdom
Dev Dyn 213:452-63. 1998..at either locus can show major deficiencies in both cell types: congenital white spotting and aganglionic megacolon (Hirschsprung disease in human)...
- Bioorganic Chemistry of Carbon Monoxide DehydrogenasePAUL LINDAHL; Fiscal Year: 2007..Health: Clostridium difficile, which contains this enzyme ACS/CODH, causes antibiotic-associated colitis, toxic megacolon, intestinal perforations and even death in humans...
- Human embryonic stem cell-derived neural crest stem cells and Hirschsprung diseaSean J Morrison; Fiscal Year: 2010Hirschsprung disease, or aganglionic megacolon, is a congenital defect that affects 1 out of 5,000 live births and is characterized by a failure to form enteric nervous system (ENS) in a variable length of the hindgut ADDIN EN...
- TAM receptor tyrosine kinases in inflammatory bowel diseaseCarla Rothlin; Fiscal Year: 2013..to serious complications due to severe inflammation, like intestinal perforation, fistula formation and/or toxic megacolon. The two main subtypes of IBD, Crohn's Disease and Ulcerative Colitis, afflict an estimated 1...
- Ednrb Regulation of Gastrointestinal MotilityKENT CHARLES WILLIAMS; Fiscal Year: 2013..in a Hirschsprung mouse model, EdnrbtmlYwa, even in mice that appear normal and do not develop aganglionic megacolon. We hypothesize that Ednrb mutation alters regulation of motility even in the absence of aganglionic megacolon...
- ET3-EDNRB Signaling in Enterocolitis Associated with Colonic AganglionosisPHILIP KENT FRYKMAN; Fiscal Year: 2013..procedure that is essentially identical to the operation performed clinically, and essentially cures aganglionic megacolon in Ednrb-/- mice, just as it does in human patients...
- Genetic Complexity and Modifiers of Hirschsprung DiseaseE Michelle Southard-Smith; Fiscal Year: 2011..The primary clinical feature, aganglionic megacolon, arises as a consequence of anomalies in development of the enteric nervous system and subsequent absence of ..
- Enteric nervous system deficits in Hirschsprung ganglionic bowelMELISSA MUSSER; Fiscal Year: 2013..Mild cases manifest as constipation while severe cases lead to toxic megacolon and death...
- Structural mechanisms of Clostridium difficile pathogenesisDANA BORDEN LACY; Fiscal Year: 2013..that infects the colon, causing a range of human disease including diarrhea, pseudomembranous colitis, and toxic megacolon. The incidence, severity, and costs associated with C...
- Aebp2 as an epigenetic regulator for neural crest cellJoomyeong Kim; Fiscal Year: 2013..that are usually seen in human patients with Hirschsprung's disease and Waardenburg syndrome, for example megacolon and hypopigmentation...
- Control of neural crest development in XenopusJean Pierre Saint-Jeannet; Fiscal Year: 2013..affecting multiple organ systems, as observed in Hirschsprung disease (hypopigmentation and aganglionic megacolon) and DiGeorge syndrome (craniofacial and heart defects)...
- Role of Endothelin Receptor B signaling in the genesis of aganglionic megacolonMiles L Epstein; Fiscal Year: 2012..The information gained here will also be relevant to transplantation of other tissues including neurons. ..
- Dynamic limits on contraction of gastrointestinal smooth muscleMARION JOYCE SIEGMAN; Fiscal Year: 2013..demand by remodeling, as in diabetes and in obstructive disorders of the gastrointestinal tract such as megacolon of Hirschsprung's disease, which are a major focus of this project...
- Sox10 in Development of the Enteric Nervous SystemE Southard Smith; Fiscal Year: 2004..development as haploinsufficiency or dominant negative forms of this transcription factor lead to aganglionic megacolon. However, little is known regarding the specific ENS cell types that derive from Sox10 precursors...
- MRI METHODS FOR ANALYSIS OF BLADDER AND GI TRACT IN MICELinda Jelicks; Fiscal Year: 2005..The digestive disease leads to megaesophagus and/or megacolon in 1/3 of chronic cases...
- FUNCTIONAL ADAPTATIONS OF INTESTINAL SMOOTH MUSCLEMARION SIEGMAN; Fiscal Year: 1992..is tonically constricted which leads to marked distension and muscular hypertrophy of the proximal colon, or "megacolon"...
- CHAGAS DISEASE: AUTOIMMUNITY STEMS FROM PARASITE INVASION OF HOST GENOMEAntonio Teixeira; Fiscal Year: 2008..unreadable] [unreadable]..
- Regulatory Molecules in Enteric Nervous SystemALCMENE CHALAZONITIS; Fiscal Year: 2006....
- Synthetic smooth muscle cell-selective promotersBRIAN HERRING; Fiscal Year: 2006..Together these studies will provide a comprehensive analysis of the mechanisms regulating smooth muscle cell-selective gene expression in the genitourinary tract. [unreadable] [unreadable] [unreadable]..
- TELOKIN GENE REGULATION IN SMOOTH MUSCLEBRIAN HERRING; Fiscal Year: 2005..The function of SRFs' interaction with these proteins will be elucidated. ..
- EXPRESSION OF THE LEISHMANIA TARENTOLAE SL RNA GENEDavid Campbell; Fiscal Year: 2003..These unique features represent potential targets for selective therapeutic intervention. ..
- BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTESEllen Ebert; Fiscal Year: 2002..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
- Function of the 130kDa MLCK in vasculature physiology and pathophysiologyBRIAN PAUL HERRING; Fiscal Year: 2010..Together these data will provide a comprehensive analysis of the roles played by the 130kDa MLCK in the vasculature under physiological and pathophysiological conditions. ..