irritable bowel syndrome

Summary

Summary: A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.

Top Publications

  1. ncbi The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects
    Anna Kassinen
    Department of Basic Veterinary Sciences, Division of Microbiology and Epidemiology, University of Helsinki, Helsinki, Finland
    Gastroenterology 133:24-33. 2007
  2. pmc Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers
    Elsa M Eriksson
    Unit for Functional Gastroenterology, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    World J Gastroenterol 14:4889-96. 2008
  3. ncbi Functional bowel disorders
    George F Longstreth
    Kaiser Permanente Medical Care Program, San Diego, California 92120, USA
    Gastroenterology 130:1480-91. 2006
  4. ncbi Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome
    Mirjana Rajilić-Stojanović
    Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
    Gastroenterology 141:1792-801. 2011
  5. ncbi Agreements among traditional Chinese medicine practitioners in the diagnosis and treatment of irritable bowel syndrome
    J J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Aliment Pharmacol Ther 20:1205-10. 2004
  6. ncbi Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Gastroenterology 139:1877-1886.e2. 2010
  7. pmc Guidelines on the irritable bowel syndrome: mechanisms and practical management
    R Spiller
    Wolfson Digestive Diseases Centre, University of Nottingham, Nottingham, UK
    Gut 56:1770-98. 2007
  8. ncbi Postinfectious irritable bowel syndrome
    Robin Spiller
    Nottingham Digestive Diseases Centre Biomedical Research Unit, University Hospital, Nottingham, England
    Gastroenterology 136:1979-88. 2009
  9. ncbi Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR
    Erja Malinen
    Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Section of Microbiology, P O Box 66, FIN 00014 University of Helsinki, Finland
    Am J Gastroenterol 100:373-82. 2005
  10. ncbi Rifaximin therapy for patients with irritable bowel syndrome without constipation
    Mark Pimentel
    Cedars Sinai Medical Center, Los Angeles, USA
    N Engl J Med 364:22-32. 2011

Detail Information

Publications332 found, 100 shown here

  1. ncbi The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects
    Anna Kassinen
    Department of Basic Veterinary Sciences, Division of Microbiology and Epidemiology, University of Helsinki, Helsinki, Finland
    Gastroenterology 133:24-33. 2007
    b>Irritable bowel syndrome (IBS) is a significant gastrointestinal disorder with unknown etiology. The symptoms can greatly weaken patients' quality of life and account for notable economical costs for society...
  2. pmc Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers
    Elsa M Eriksson
    Unit for Functional Gastroenterology, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    World J Gastroenterol 14:4889-96. 2008
    To elucidate the differences in somatic, psychological and biochemical pattern between the subtypes of irritable bowel syndrome (IBS).
  3. ncbi Functional bowel disorders
    George F Longstreth
    Kaiser Permanente Medical Care Program, San Diego, California 92120, USA
    Gastroenterology 130:1480-91. 2006
    ..b>Irritable bowel syndrome (IBS), functional bloating, functional constipation, and functional diarrhea are best identified by ..
  4. ncbi Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome
    Mirjana Rajilić-Stojanović
    Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
    Gastroenterology 141:1792-801. 2011
    b>Irritable bowel syndrome (IBS) has been associated with disruptions to the intestinal microbiota, but studies have had limited power, coverage, and depth of analysis...
  5. ncbi Agreements among traditional Chinese medicine practitioners in the diagnosis and treatment of irritable bowel syndrome
    J J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Aliment Pharmacol Ther 20:1205-10. 2004
    Traditional Chinese Medicine was frequently used by patients with irritable bowel syndrome.
  6. ncbi Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Gastroenterology 139:1877-1886.e2. 2010
    ..of guanylate cyclase-C, has shown benefit in a proof-of-concept study for the treatment of patients with irritable bowel syndrome (IBS) with constipation (IBS-C)...
  7. pmc Guidelines on the irritable bowel syndrome: mechanisms and practical management
    R Spiller
    Wolfson Digestive Diseases Centre, University of Nottingham, Nottingham, UK
    Gut 56:1770-98. 2007
    ..IBS affects 5-11% of the population of most countries. Prevalence peaks in the third and fourth decades, with a female predominance...
  8. ncbi Postinfectious irritable bowel syndrome
    Robin Spiller
    Nottingham Digestive Diseases Centre Biomedical Research Unit, University Hospital, Nottingham, England
    Gastroenterology 136:1979-88. 2009
    Approximately 1 in ten patients with irritable bowel syndrome (IBS) believe their IBS began with an infectious illness...
  9. ncbi Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR
    Erja Malinen
    Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Section of Microbiology, P O Box 66, FIN 00014 University of Helsinki, Finland
    Am J Gastroenterol 100:373-82. 2005
    The gut microbiota may contribute to the onset and maintenance of irritable bowel syndrome (IBS). In this study, the microbiotas of patients suffering from IBS were compared with a control group devoid of gastrointestinal (GI) symptoms.
  10. ncbi Rifaximin therapy for patients with irritable bowel syndrome without constipation
    Mark Pimentel
    Cedars Sinai Medical Center, Los Angeles, USA
    N Engl J Med 364:22-32. 2011
    Evidence suggests that gut flora may play an important role in the pathophysiology of the irritable bowel syndrome (IBS). We evaluated rifaximin, a minimally absorbed antibiotic, as treatment for IBS.
  11. ncbi An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
    Ian B Jeffery
    Department of Microbiology, University College Cork, Cork, Ireland
    Gut 61:997-1006. 2012
    b>Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder that may be triggered by enteric pathogens and has also been linked to alterations in the microbiota and the host immune response...
  12. ncbi Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?
    Timothy G Dinan
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Gastroenterology 130:304-11. 2006
    b>Irritable bowel syndrome (IBS) is a functional disorder with an etiology that has been linked to both psychological stress and infection...
  13. ncbi The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review
    P Moayyedi
    Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, HSC 4W8E, Hamilton, ON L8N 3Z5, Canada
    Gut 59:325-32. 2010
    Probiotics may benefit irritable bowel syndrome (IBS) symptoms, but randomised controlled trials (RCTs) have been conflicting; therefore a systematic review was conducted.
  14. ncbi Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation
    A Agrawal
    Neurogastroenterology Unit, Translational Medicine GI Sciences, University of Manchester, UK
    Aliment Pharmacol Ther 29:104-14. 2009
    A sensation of abdominal swelling (bloating) and actual increase in girth (distension) are troublesome features of irritable bowel syndrome (IBS), which is more common in patients with constipation, especially those with delayed transit.
  15. ncbi Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietary advice in patients with irritable bowel syndrome
    H M Staudacher
    King s College London, Nutritional Sciences Division, London, UK
    J Hum Nutr Diet 24:487-95. 2011
    ..disaccharides, monosaccharides and polyols (FODMAPs) may result in symptoms in some patients with irritable bowel syndrome (IBS)...
  16. ncbi Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis
    A C Ford
    Gastroenterology Division, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Gut 58:367-78. 2009
    b>Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder. Evidence for treatment of the condition with antidepressants and psychological therapies is conflicting.
  17. ncbi Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
    Anne Salonen
    Department of Veterinary Biosciences, Veterinary Microbiology and Epidemiology, University of Helsinki, PO Box 66, FI 00014 Helsinki, Finland
    Microbiology 156:3205-15. 2010
    b>Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that has been associated with aberrant microbiota...
  18. ncbi Systematic review and meta-analysis: The incidence and prognosis of post-infectious irritable bowel syndrome
    M Thabane
    Division of Gastroenterology, Department of Medicine, and Intestinal Diseases Research Program, McMaster University Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 26:535-44. 2007
    Individual studies suggest that post-infectious irritable bowel syndrome is common, but symptoms gradually improve.
  19. ncbi The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review
    Darren M Brenner
    Division of Gastroenterology, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Ann Arbor, Michigan, USA
    Am J Gastroenterol 104:1033-49; quiz 1050. 2009
    b>Irritable bowel syndrome (IBS) is a common disorder and available therapies have limited efficacy...
  20. ncbi Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome
    Simon P Dunlop
    Division of Gastroenterology, University Hospital, Nottingham NG7 2UH, UK
    Clin Gastroenterol Hepatol 3:349-57. 2005
    ..5-hydroxytryptamine-3 (5-HT 3 ) receptor antagonists improve symptoms in patients with diarrhea-predominant irritable bowel syndrome (D-IBS), 5-HT 4 agonists help those with constipation-predominant IBS (C-IBS)...
  21. pmc Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome
    Erja Malinen
    Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, 00014 Helsinki, Finland
    World J Gastroenterol 16:4532-40. 2010
    To investigate the correlations between self-reported symptoms of irritable bowel syndrome (IBS) and the gastrointestinal (GI) microbiota composition.
  22. ncbi Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
    Giovanni Barbara
    Department of Internal Medicine and Gastroenterology, and CRBA, University of Bologna, St Orsola Hospital, Via Massarenti 9, I 40138 Bologna, Italy
    Gastroenterology 132:26-37. 2007
    Intestinal mast cell infiltration may participate to abdominal pain in irritable bowel syndrome (IBS) patients. However, the underlying mechanisms remain unknown...
  23. pmc Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome
    Delphine M Saulnier
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA
    Gastroenterology 141:1782-91. 2011
    The intestinal microbiomes of healthy children and pediatric patients with irritable bowel syndrome (IBS) are not well defined. Studies in adults have indicated that the gastrointestinal microbiota could be involved in IBS.
  24. ncbi Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
    Matthew D Coates
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Gastroenterology 126:1657-64. 2004
    ..Despite being pathophysiologically divergent, ulcerative colitis (UC) and irritable bowel syndrome (IBS) are both associated with clinical symptoms that include alterations in the normal patterns of ..
  25. ncbi Differential expression of toll-like receptors in patients with irritable bowel syndrome
    Elizabeth K Brint
    Department of Pathology, University College Cork, National University of Ireland, and Alimentary Pharmabiotic Centre, Cork University Hospital, Cork, Ireland
    Am J Gastroenterol 106:329-36. 2011
    The pathogenesis of irritable bowel syndrome (IBS) is poorly understood. One contributory factor may be low-grade mucosal inflammation, perhaps initiated by the microbiota...
  26. ncbi Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome
    D B A Silk
    Department of Academic Surgery, Imperial College Healthcare NHS Trust, London, UK
    Aliment Pharmacol Ther 29:508-18. 2009
    Gut microflora-mucosal interactions may be involved in the pathogenesis of irritable bowel syndrome (IBS).
  27. ncbi Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome
    C Tana
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neurogastroenterol Motil 22:512-9, e114-5. 2010
    The profile of intestinal organic acids in irritable bowel syndrome (IBS) and its correlation with gastrointestinal (GI) symptoms are not clear...
  28. ncbi Review article: Associations between immune activation, intestinal permeability and the irritable bowel syndrome
    J Matricon
    Clermont Universite, Universite d Auvergne, NEURO DOL, Clermont Ferrand, France INSERM, Clermont Ferrand, France
    Aliment Pharmacol Ther 36:1009-31. 2012
    b>Irritable bowel syndrome (IBS), one of the most common gastrointestinal disorders, markedly impairing patients' quality of life. Drug development for IBS treatment has been hampered by the lack of understanding of IBS aetiology...
  29. ncbi Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease
    Kevin Whelan
    King s College London, School of Medicine, Diabetes and Nutritional Sciences Division, London, UK
    Curr Opin Gastroenterol 29:184-9. 2013
    ..the gastrointestinal microbiota and some evidence that the microbiota might also play a similar role in irritable bowel syndrome (IBS)...
  30. ncbi A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome
    Y A Saito
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:465-70. 2007
    ..performed a case-control association study to determine whether these polymorphisms are associated with irritable bowel syndrome (IBS)...
  31. pmc Prevalence of irritable bowel syndrome: a community survey
    Sue Wilson
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston
    Br J Gen Pract 54:495-502. 2004
    b>Irritable bowel syndrome (IBS) is a common health problem affecting a substantial proportion of the population...
  32. pmc Association of TNFSF15 polymorphism with irritable bowel syndrome
    Marco Zucchelli
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    Gut 60:1671-7. 2011
    b>Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder, affecting more than 10% of the general population worldwide...
  33. ncbi Relative importance of abnormalities of CCK and 5-HT (serotonin) in Giardia-induced post-infectious irritable bowel syndrome and functional dyspepsia
    V Dizdar
    Institute of Medicine, University of Bergen, Bergen, Norway
    Aliment Pharmacol Ther 31:883-91. 2010
    Post-infectious irritable bowel syndrome (PI-IBS) and functional dyspepsia (FD) have been described after both Campylobacter jejuni gastroenteritis and Giardia infection. After C...
  34. pmc Evaluation of the Birmingham IBS symptom questionnaire
    Andrea K Roalfe
    Department of Primary Care and General Practice, Division of Primary Care, Public and Occupational Health, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    BMC Gastroenterol 8:30. 2008
    b>Irritable Bowel Syndrome (IBS) is a chronic/common condition that causes a significant effect on the individual (reduced quality of life), society (time lost off work) and health services...
  35. ncbi Irritable bowel syndrome: the role of gut neuroendocrine peptides
    Magdy El-Salhy
    Section for Gastroenterology, Department of Medicine, Stord Helse Fonna Hospital, Norway
    Front Biosci (Elite Ed) 4:2783-800. 2012
    b>Irritable bowel syndrome (IBS) is a common chronic disorder with a prevalence ranging from 5 to 10 percent of the world's population...
  36. ncbi Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Charlton 8 110, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 303:G775-85. 2012
    b>Irritable bowel syndrome (IBS) is one of the most common gastrointestinal ailments among those seeking health care for gastrointestinal disorders. Despite its prevalence, IBS pathophysiology is still not completely understood...
  37. pmc Low densities of serotonin and peptide YY cells in the colon of patients with irritable bowel syndrome
    M el-Salhy
    Section for Gastroenterology, Department of Medicine, Stord Helse Fonna Hospital, Box 4000, 54 09 Stord, Norway
    Dig Dis Sci 57:873-8. 2012
    ..Disturbances in gastrointestinal motility have been reported in patients with irritable bowel syndrome (IBS)...
  38. ncbi The efficacy and safety of rifaximin for the irritable bowel syndrome: a systematic review and meta-analysis
    Stacy B Menees
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, 48109 5362, USA
    Am J Gastroenterol 107:28-35; quiz 36. 2012
    b>Irritable bowel syndrome (IBS) affects 10-15% of the population, and treatment options are limited. Rifaximin is a minimally absorbed antibiotic that has shown efficacy in IBS patients...
  39. ncbi Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms
    Cesare Cremon
    Department of Internal Medicine and Gastroenterology, St Orsola Hospital, Center for Applied Biomedical Research, Bologna, Italy
    Am J Gastroenterol 104:392-400. 2009
    Immune activation may be involved in the pathogenesis of irritable bowel syndrome (IBS)...
  40. ncbi Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators
    T Piche
    INSERM U913, Nantes, France
    Gut 58:196-201. 2009
    Growing evidence suggests that patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS...
  41. ncbi Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome
    Cesare Cremon
    Department of Clinical Medicine and Center for Applied Biomedical Research, University of Bologna, Bologna, Italy
    Am J Gastroenterol 106:1290-8. 2011
    Serotonin (5-hydroxytryptamine, 5-HT) metabolism may be altered in gut disorders, including in the irritable bowel syndrome (IBS). We assessed in patients with IBS vs...
  42. pmc Deficiency in endogenous modulation of prolonged heat pain in patients with Irritable Bowel Syndrome and Temporomandibular Disorder
    Christopher D King
    Department of Community Dentistry and Behavioral Science, University of Florida College of Dentistry, 1329 SW 16th Street, Suite 5180, PO Box 103628, Gainesville, FL 32610 3628, USA
    Pain 143:172-8. 2009
    Females with Irritable Bowel Syndrome (IBS) and Temporomandibular Disorder (TMD) are characterized by enhanced sensitivity to experimental pain...
  43. pmc MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome
    QiQi Zhou
    Department of Medicine, Ohio State University, 1799 W 5th Avenue, Columbus, OH 43212, USA
    Gut 59:775-84. 2010
    The molecular mechanisms underlying the pathophysiology of irritable bowel syndrome (IBS) are poorly understood. One mechanism may involve increased intestinal permeability that is reversed with glutamine supplementation...
  44. ncbi Mechanisms of hypersensitivity in IBS and functional disorders
    F Azpiroz
    Digestive System Research Unit, University Hospital Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    Neurogastroenterol Motil 19:62-88. 2007
    ....
  45. ncbi Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles
    Liam O'Mahony
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Gastroenterology 128:541-51. 2005
    The aim of this study was to compare the response of symptoms and cytokine ratios in irritable bowel syndrome (IBS) with ingestion of probiotic preparations containing a lactobacillus or bifidobacterium strain.
  46. pmc Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome
    Kirsten Tillisch
    Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Gastroenterology 140:91-100. 2011
    The responsiveness of the central nervous system is altered in patients with irritable bowel syndrome (IBS)...
  47. ncbi Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome
    C Chassard
    INRA, UR Microbiology Unit, Clermont Ferrand Research Centre, Saint Genes Champanelle, France
    Aliment Pharmacol Ther 35:828-38. 2012
    The role of the gut microbiota in patho-physiology of irritable bowel syndrome (IBS) is suggested by several studies...
  48. ncbi Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial
    Jessica R Biesiekierski
    Monash University Department of Medicine and Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    Am J Gastroenterol 106:508-14; quiz 515. 2011
    ..The aims of this study were to determine whether gluten ingestion can induce symptoms in non-celiac individuals and to examine the mechanism...
  49. ncbi Postinfectious irritable bowel syndrome--a meta-analysis
    Heather A Halvorson
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20817 4799, USA
    Am J Gastroenterol 101:1894-9; quiz 1942. 2006
    b>Irritable bowel syndrome (IBS) is a heterogeneous disorder affecting 12% of the population worldwide...
  50. pmc Placebos without deception: a randomized controlled trial in irritable bowel syndrome
    Ted J Kaptchuk
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e15591. 2010
    ..We tested whether open-label placebo (non-deceptive and non-concealed administration) is superior to a no-treatment control with matched patient-provider interactions in the treatment of irritable bowel syndrome (IBS).
  51. pmc Clinical practice. Irritable bowel syndrome
    Emeran A Mayer
    Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6949, USA
    N Engl J Med 358:1692-9. 2008
  52. ncbi Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα
    Caroline Swan
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK
    Gut 62:985-94. 2013
    The postinfectious irritable bowel syndrome (PI-IBS) suggests that impaired resolution of inflammation could cause IBS symptoms...
  53. pmc Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1075-84. 2012
    ..Our first objective is to evaluate the evidence supporting a role for genetics in irritable bowel syndrome (IBS)...
  54. pmc Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome
    I M Carroll
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Neurogastroenterol Motil 24:521-30, e248. 2012
    The intestinal microbiota has been implicated in the pathophysiology of irritable bowel syndrome (IBS)...
  55. ncbi Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients
    Hsing Feng Lee
    Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan
    Pain 153:1301-10. 2012
    Placebo analgesia is a psychosocial context effect that is rarely studied in visceral pain. Patients with irritable bowel syndrome (IBS) exhibit visceral hyperalgesia and heightened affective/cognitive brain region activation during ..
  56. pmc Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome
    Kathryn T Hall
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e48135. 2012
    ..our hypothesis in a subset of 104 patients from a previously reported randomized controlled trial in irritable bowel syndrome (IBS)...
  57. pmc Irritable bowel syndrome: diagnosis and pathogenesis
    Magdy El-Salhy
    Section for Gastroenterology, Department of Medicine, Stord Helse Fonna Hospital, 5416 Stord, Norway
    World J Gastroenterol 18:5151-63. 2012
    b>Irritable bowel syndrome (IBS) is a common gastrointestinal (GI) disorder that considerably reduces the quality of life...
  58. pmc How patients view probiotics: findings from a multicenter study of patients with inflammatory bowel disease and irritable bowel syndrome
    MaryBeth Mercer
    Department of Bioethics, Cleveland Clinic, Cleveland, OH 44195, USA
    J Clin Gastroenterol 46:138-44. 2012
    Patients with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) have access to a growing number of probiotic products marketed to improve digestive health...
  59. ncbi VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover study
    Stefano Guandalini
    University of Chicago Section of Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL, USA
    J Pediatr Gastroenterol Nutr 51:24-30. 2010
    b>Irritable bowel syndrome (IBS) is a common problem in pediatrics, for which no safe and effective treatment is available...
  60. ncbi Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis
    Rebecca M Lovell
    Leeds Gastroenterology Institute, St James s University Hospital, Leeds, United Kingdom
    Clin Gastroenterol Hepatol 10:712-721.e4. 2012
    Many cross-sectional surveys have reported the prevalence of irritable bowel syndrome (IBS), but there have been no recent systematic review of data from all studies to determine its global prevalence and risk factors.
  61. pmc Acceptability, effectiveness, and cost-effectiveness of internet-based exposure treatment for irritable bowel syndrome in a clinical sample: a randomized controlled trial
    Brjann Ljotsson
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
    BMC Gastroenterol 11:110. 2011
    Internet-based cognitive behavior therapy (ICBT) has shown promising effects in the treatment of irritable bowel syndrome (IBS)...
  62. pmc The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome
    Ruth Kohen
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195 6560, USA
    Dig Dis Sci 54:2663-70. 2009
    b>Irritable bowel syndrome is a frequent gastrointestinal disorder of unknown etiology...
  63. ncbi Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome
    Derrick K Ong
    Department of Medicine, Eastern Health Clinical School, Monash University, Victoria, Australia
    J Gastroenterol Hepatol 25:1366-73. 2010
    Reduction of short-chain poorly absorbed carbohydrates (FODMAPs) in the diet reduces symptoms of irritable bowel syndrome (IBS)...
  64. pmc Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome
    Bin Feng
    Center for Pain Research, Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1085-98. 2012
    b>Irritable bowel syndrome (IBS) is characterized as functional because a pathobiological cause is not readily apparent...
  65. ncbi Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 184:1358-63. 2010
    ..of clinical phenotypic associations between interstitial cystitis/painful bladder syndrome and controls in relation to potentially related conditions, particularly irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.
  66. pmc Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial
    W Atkinson
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 53:1459-64. 2004
    Patients with irritable bowel syndrome (IBS) often feel they have some form of dietary intolerance and frequently try exclusion diets...
  67. pmc Microbial community and metabolomic comparison of irritable bowel syndrome faeces
    Kannan Ponnusamy
    Department of Bioscience and Biotechnology and Bio Molecular Informatics Center, Konkuk University, Seoul 143 701, Republic of Korea
    J Med Microbiol 60:817-27. 2011
    ..001) in faecal samples from patients with irritable bowel syndrome (IBS; n = 11) and from non-IBS (nIBS) patients (n = 8)...
  68. ncbi Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study
    W Z Lu
    Department of Pharmacology, National University of Singapore
    Aliment Pharmacol Ther 22:927-34. 2005
    ..Melatonin is involved in the regulation of gastrointestinal motility and sensation...
  69. ncbi Altered intestinal microbiota in irritable bowel syndrome
    K J Lee
    Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea
    Neurogastroenterol Motil 22:493-8. 2010
    ..suggested that alterations in the composition of the intestinal microbiota may play an important role in irritable bowel syndrome (IBS) symptoms...
  70. ncbi Irritable bowel syndrome: role of food in pathogenesis and management
    Ashraf Morcos
    Department of Gastroenterology and Internal Medicine, Midwestern Regional Hospital, Limerick, Ireland
    J Dig Dis 10:237-46. 2009
    Patients with the irritable bowel syndrome (IBS) commonly report the precipitation of symptoms on food ingestion...
  71. ncbi Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndrome
    A K Campbell
    Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF103NB, UK
    Toxicology 278:268-76. 2010
    ..This new mechanism also explains the most common referral to gastroenterologists, irritable bowel syndrome (IBS), and the illness that afflicted Charles Darwin for 50 years (Campbell and Matthews, 2005a,b)...
  72. ncbi Psychosocial factors at work and in every day life are associated with irritable bowel syndrome
    Ashild Faresjo
    Department of Social Medicine and Public Health Science, Linkoping University, Linkoping, 581 83, Sweden
    Eur J Epidemiol 22:473-80. 2007
    The etiology of irritable bowel syndrome (IBS) tends to be complex and multi-factorial and there is still a lack of understanding of how different psychosocial factors are associated with the syndrome...
  73. pmc Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls
    C H Wilder-Smith
    Brain Gut Research Group, Bubenbergplatz 11, CH 3011 Berne, Switzerland
    Gut 53:1595-601. 2004
    Many patients with irritable bowel syndrome (IBS) show intestinal hypersensitivity to distension and sensitisation after repeated intestinal distensions...
  74. ncbi Role of serotonin in gastrointestinal motility and irritable bowel syndrome
    Arbab Sikander
    Department of Super specialty of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India
    Clin Chim Acta 403:47-55. 2009
    ..b>Irritable bowel syndrome (IBS) is a complex disorder that is associated with altered gastrointestinal motility, secretion and ..
  75. ncbi Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome
    Gwénaëlle Le Gall
    Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom
    J Proteome Res 10:4208-18. 2011
    ..differences in metabolic activity of gut microbiota in patients with ulcerative colitis (UC) (n = 13), irritable bowel syndrome (IBS) (n = 10), and healthy controls (C) (n = 22)...
  76. ncbi A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome
    Caroline Codling
    Department of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital, Cork, Ireland
    Dig Dis Sci 55:392-7. 2010
    The objectives of this study were, firstly, to determine the diversity of the host's gut microbiota in irritable bowel syndrome (IBS) using a culture-independent method (DGGE of the 16S rRNA gene) and, secondly, to examine mucosal ..
  77. ncbi Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study
    Mark Pimentel
    Cedars Sinai Medical Center, Burns and Allen Research Institute, UCLA Geffen School of Medicine, 8635 W 3rd St, Suite 770, Los Angeles, California 90034, USA
    Dig Dis Sci 51:1297-301. 2006
    ..that normalization of the lactulose breath test (LBT) with neomycin leads to a significant reduction in irritable bowel syndrome (IBS) symptoms...
  78. ncbi Asian consensus on irritable bowel syndrome
    Kok Ann Gwee
    Stomach Liver and Bowel Clinic, Gleneagles Hospital, Singapore
    J Gastroenterol Hepatol 25:1189-205. 2010
    Many of the ideas on irritable bowel syndrome (IBS) are derived from studies conducted in Western societies. Their relevance to Asian societies has not been critically examined...
  79. pmc Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
    Mar Guilarte
    Department of Medicine, Hospital Universitari General Vall d Hebron, 08035 Barcelona, Spain
    Gut 56:203-9. 2007
    ..cells and mast cell activation in distal gut segments are associated with symptom onset and severity in irritable bowel syndrome (IBS)...
  80. ncbi Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS
    Simon P Dunlop
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, England
    Gastroenterology 125:1651-9. 2003
    ..increased enterochromaffin [EC] cells and T lymphocytes) have been associated with postinfectious irritable bowel syndrome (PI-IBS)...
  81. ncbi Irritable bowel syndrome: epidemiology, diagnosis and treatment: an update for health-care practitioners
    Oliver Grundmann
    College of Pharmacy, Department of Medicinal Chemistry, University of Florida, FL 32610, USA
    J Gastroenterol Hepatol 25:691-9. 2010
    b>Irritable bowel syndrome (IBS), a chronic gastrointestinal disorder, affects from 3-20% of the US population, depending on sociocultural and comorbid factors...
  82. ncbi Immune activation in patients with irritable bowel syndrome
    Tobias Liebregts
    Department of Gastroenterology and Hepatology, University of Adelaide, Royal Adelaide Hospital, South Australia, Australia
    Gastroenterology 132:913-20. 2007
    We set out to test the hypothesis that irritable bowel syndrome (IBS) is characterized by an augmented cellular immune response with enhanced production of proinflammatory cytokines...
  83. pmc Role for protease activity in visceral pain in irritable bowel syndrome
    Nicolas Cenac
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 117:636-47. 2007
    Mediators involved in the generation of symptoms in patients with irritable bowel syndrome (IBS) are poorly understood...
  84. pmc Microbial community analysis reveals high level phylogenetic alterations in the overall gastrointestinal microbiota of diarrhoea-predominant irritable bowel syndrome sufferers
    Lotta Krogius-Kurikka
    Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, PO Box 66, FI 00014 University of Helsinki, Helsinki, Finland
    BMC Gastroenterol 9:95. 2009
    A growing amount of scientific evidence suggests that microbes are involved in the aetiology of irritable bowel syndrome (IBS), and the gastrointestinal (GI) microbiota of individuals suffering from diarrhoea-predominant IBS (IBS-D) is ..
  85. ncbi Discriminating IBD from IBS: comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodies
    Alain M Schoepfer
    Department of Gastroenterology, Inselspital University of Bern, Switzerland
    Inflamm Bowel Dis 14:32-9. 2008
    Symptoms of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) can overlap...
  86. pmc Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women
    A Yeo
    Novartis Pharmaceuticals Corporation, USCDMA, One Health Plaza, East Hanover, NJ 07936 1080, USA
    Gut 53:1452-8. 2004
    ..polymorphisms may underlie disturbance in gut function in individuals suffering with disorders such as irritable bowel syndrome (IBS)...
  87. ncbi The Incidence and gastrointestinal infectious risk of functional gastrointestinal disorders in a healthy US adult population
    Chad K Porter
    Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    Am J Gastroenterol 106:130-8. 2011
    ..Within the active duty military population, a group with known high IGE rates, the population-based incidence, risk factors, and attributable burden of care referable to FGD after IGE are poorly defined...
  88. ncbi Long-term follow-up of internet-delivered exposure and mindfulness based treatment for irritable bowel syndrome
    Brjann Ljotsson
    Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Behav Res Ther 49:58-61. 2011
    ..2010). Internet-delivered exposure and mindfulness based therapy for irritable bowel syndrome - a randomized controlled trial. Behaviour Research and Therapy, 48, 531-539)...
  89. ncbi Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    Giovanni Barbara
    Departmentof Internal Medicine and Gastroenterology, and CRBA, University of Bologna, Italy
    Gastroenterology 126:693-702. 2004
    The mechanisms underlying abdominal pain perception in irritable bowel syndrome (IBS) are poorly understood. Intestinal mast cell infiltration may perturb nerve function leading to symptom perception...
  90. ncbi Intestinal microecology and quality of life in irritable bowel syndrome patients
    Jian min Si
    Department of Gastroenterology, Sir Run Run Shaw Affiliated Hospital of Zhejiang University, Hangzhou 310016, Zhejiang Province, China
    World J Gastroenterol 10:1802-5. 2004
    It has been noticed that gastroenteritis or dysentery plays a role in pathogenesis of irritable bowel syndrome (IBS), and antibiotics can increase functional abdominal symptoms, both of which may be partly due to intestinal flora ..
  91. ncbi Review article: probiotics for the treatment of irritable bowel syndrome--focus on lactic acid bacteria
    G Clarke
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 35:403-13. 2012
    b>Irritable bowel syndrome (IBS) is a poorly understood, yet highly prevalent functional gastrointestinal disorder (FGID)...
  92. ncbi Mindfulness training reduces the severity of irritable bowel syndrome in women: results of a randomized controlled trial
    SUSAN A GAYLORD
    Program on Integrative Medicine, Department of Physical Medicine and Rehabilitation, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599 7200, USA E mail
    Am J Gastroenterol 106:1678-88. 2011
    ..and efficacy of a group program of mindfulness training, a cognitive-behavioral technique, for women with irritable bowel syndrome (IBS)...
  93. ncbi Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome
    Peter J Whorwell
    Department of Medicine, University of Manchester, Manchester, UK
    Am J Gastroenterol 101:1581-90. 2006
    ..Thus, not all species will necessarily have the same therapeutic potential in a particular condition. We have preliminary evidence that Bifidobacterium infantis 35624 may have utility in irritable bowel syndrome (IBS).
  94. ncbi Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study
    Knut Arne Wensaas
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Gut 61:214-9. 2012
    ..Giardia lamblia is a common cause of gastroenteritis worldwide, but there is limited knowledge about the long-term complications...
  95. ncbi Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
    Luca Marciani
    Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Queen s Medical Centre Campus, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, United Kingdom
    Gastroenterology 138:469-77, 477.e1. 2010
    Postprandial symptoms are common in patients with irritable bowel syndrome with diarrhea (IBS-D) and could be diet related...
  96. ncbi Irritable bowel syndrome: in search of an etiology: role of Blastocystis hominis
    Javed Yakoob
    Departments of Medicine and Pathology, Aga Khan University Hospital, Karachi, Pakistan
    Am J Trop Med Hyg 70:383-5. 2004
    This study was designed to examine stool specimens of irritable bowel syndrome (IBS) patients for Blastocystis hominis, a common intestinal parasite. One hundred fifty patients were enrolled, 95 IBS cases and 55 controls...
  97. ncbi Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses
    Siobhain M O'Mahony
    Alimentary Pharmabiotic Centre, Cork, Ireland
    Biol Psychiatry 65:263-7. 2009
    ..Several disorders have been associated with early life stress, ranging from depression to irritable bowel syndrome. This makes the identification of the neurobiological substrates that are affected by adverse experiences ..
  98. ncbi Comorbidity in irritable bowel syndrome
    William E Whitehead
    Center for Functional GI and Motility Disorders at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7555, USA
    Am J Gastroenterol 102:2767-76. 2007
    Comorbid nongastrointestinal symptoms account for two-thirds of excess health-care costs in irritable bowel syndrome (IBS).
  99. ncbi Infection, inflammation, and the irritable bowel syndrome
    R Spiller
    Nottingham Digestive Diseases Centre Biomedical Research Unit, University Hospital, Nottingham, United Kingdom
    Dig Liver Dis 41:844-9. 2009
    ..recover, however around 25% have long lasting changes in bowel habit and a smaller number develop the irritable bowel syndrome (IBS). Whether the incidence is similar in developing countries is unknown...
  100. pmc The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome
    Guang Yin Xu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Mol Pain 5:44. 2009
    The pathogenesis of visceral hypersensitivity, a characteristic pathophysiological feature of irritable bowel syndrome (IBS), remains elusive...
  101. ncbi Small intestinal bacterial overgrowth in irritable bowel syndrome: systematic review and meta-analysis
    Alexander C Ford
    Gastroenterology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada
    Clin Gastroenterol Hepatol 7:1279-86. 2009
    Small intestinal bacterial overgrowth (SIBO) has been proposed as an etiologic factor in irritable bowel syndrome (IBS), but evidence is conflicting. We conducted a systematic review and meta-analysis of the prevalence of SIBO in IBS.

Research Grants70

  1. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..CFS often occurs with comorbid diseases such as fibromyalgia, irritable bowel syndrome (IBS), interstitial cystitis (IC) and migraines, all of which also worsen by stress...
  2. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..CFS is often comorbid with other disorders that include fibromyalgia, interstitial cystitis (1C), irritable bowel syndrome (IBS), migraines and post-traumatic stress disorder...
  3. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..Using 2 rat models of chronic psychological stress validated for irritable bowel syndrome and depression, we propose to evaluate 1) whether chronic stress affects visceral adiposity and the ..
  4. Iyengar yoga for adolescents and young adults with irritable bowel syndrome
    Subhadra Evans; Fiscal Year: 2013
    ..Scientist Development Award (K01) entitled 'Iyengar yoga for adolescents and young adults with irritable bowel syndrome'is a first resubmission in response to PA-09-040 (previously PA-06-001)...
  5. Irritable bowel syndrome-diarrhea: the role of gluten intolerance and HLA-DQ2
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..There is epidemiological evidence of significant overlap between irritable bowel syndrome (IBS) and functional chronic diarrhea [FD (Locke et al 2005)]...
  6. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
    ..and tenderness, disturbances in sleep, and co-occurrence of other generalized pain syndromes, such as irritable bowel syndrome and post-traumatic stress disorder...
  7. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    b>Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is characterized by recurrent abdominal pain and disturbance in bowel movements...
  8. Modulation of Colonic Epithelial Permeability by Sex Hormones
    Muriel Larauche; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Women are predominantly affected by irritable bowel syndrome (IBS). The reason for this prevalence is not yet established...
  9. Epigenetic regulation of stem cell senescence in aging
    DAVID TOCHUKWU ASUZU; Fiscal Year: 2011
    ..Age-related changes in the GI tract include increased gastroesophageal reflux, irritable bowel syndrome, constipation and fecal incontinence, as well as more subtle dysfunctions such as inability to consume ..
  10. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ..in the initiation or aggravation of chronic diseases like atopic dermatitis, inflammatory bowel disease, irritable bowel syndrome, asthma, and rheumatoid arthritis...
  11. Central Mechanisms Modulating Visceral Sensitivity
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..by increased awareness of visceral stimuli, similar to patients with functional GI disorders such as irritable bowel syndrome (IBS)...
  12. Molecular mechanism of regulation of mI(CAT) in intestinal smooth muscle cells
    Michael X Zhu; Fiscal Year: 2012
    ..a wide range of human diseases caused by smooth muscle dysfunctions, such as inflammatory bowel disease, irritable bowel syndrome, and urge incontinence...
  13. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..occurs in intestinal disorders besides IBD, including necrotizing enterocolitis, infectious diarrhea, and irritable bowel syndrome;the ENS may contribute to any or all of them...
  14. Chronic stress-induced gene expression in colonic circular smooth muscle cells.
    Sushil K Sarna; Fiscal Year: 2012
    ..exacerbate or precipitate the symptoms of colonic motility dysfunction in inflammatory bowel disease and irritable bowel syndrome. The findings of this proposal are expected to identify the potential molecular therapeutic approaches ..
  15. Bile Acids, Genetic Control and Colonic Function in Irritable Bowel Syndrome
    MICHAEL L CAMILLERI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Irritable bowel syndrome (IBS) is a disorder of lower gastrointestinal function associated with mucosal immune activation, colonic motor and sensory dysfunctions...
  16. Mechanisms of Interleukin-17 Inflammation Induced by Bacteroides fragilis
    CYNTHIA SEARS; Fiscal Year: 2012
    ..inflammation may also help in identifying treatments for individuals afflicted by inflammatory bowel disease (Crohn's disease and ulcerative colitis) and irritable bowel syndrome, an illness disproportionately affecting women.
  17. Role of cannabinoid 2 receptors in B lymphocyte function
    Catherine E Patterson; Fiscal Year: 2010
    ..Cannabinoids and related compounds have been proposed for use in treating rheumatoid arthritis and irritable bowel syndrome and have actually been used in clinical trials for brain injury, multiple sclerosis and HIV-induced ..
  18. Sex Hormones and Visceral Hypersensitivity
    Elie D Al-Chaer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pain and visceral hypersensitivity are the main characteristics of irritable bowel syndrome (IBS), an extremely common disorder affecting up to 15% of the US population with a major socioeconomic ..
  19. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2013
    ..is also implicated in diabetic gastroparesis and functional disorders of the gut such as irritable bowel syndrome and spasm of biliary and pancreatic sphincters...
  20. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..components of the intestinal serotonin signaling system is associated with digestive diseases including Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), and celiac disease...
  21. Mechanisms underlying TMD-IBS comorbidity
    Richard J Traub; Fiscal Year: 2013
    ..of patients with temporomandibular disorder (TMD) also report symptoms of abdominal pain consistent with irritable bowel syndrome (IBS), but the underlying connection between these comorbid conditions is unclear...
  22. Control of Nociception in the Spinal Cord
    Sukhbir S Mokha; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Many pain syndromes/disorders observed below the head region, such as irritable bowel syndrome (IBS), fibromyalgia, vulvodynia, endometriosis and pelvic pain, have a greater prevalence in women or are ..
  23. Diagnostic tools to link Bacteroides fragilis toxin isotypes and human disease
    Saraspadee Mootien; Fiscal Year: 2012
    ..Long term sequelae include irritable bowel syndrome and growth delay in children...
  24. STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
    YVETTE FRANCE TACHE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Irritable bowel syndrome (IBS) is a stress-sensitive disorder for which abdominal pain is a cardinal symptom that drives illness severity more than other motor symptoms...
  25. Sex-specific genetic architecture of irritable bowel syndrome
    Lisa A Kilpatrick; Fiscal Year: 2013
    ..However, the study of genetics in irritable bowel syndrome (IBS) is in its infancy and has been hampered by a focus on clinical phenotype association studies...
  26. Regulation of gastrointestinal neuromuscular function by NIBP/NFkB signaling
    Wenhui Hu; Fiscal Year: 2013
    ..and functional abnormalities in adult ENS have been associated with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), gastroparesis and chronic constipation/diarrhea...
  27. SERT KO rats are a model of sex specific visceral pain
    James J Galligan; Fiscal Year: 2013
    ..increased 5-HT availability in female SERT KO rats alters visceral sensitivity as occurs in female human irritable bowel syndrome patients...
  28. Urocortin &Musculoskeletal Hyperalgesia
    Alice A Larson; Fiscal Year: 2013
    ..painful musculoskeletal disorders, such as fibromyalgia, and various painful abdominal disorders, such as irritable bowel syndrome and interstitial cystitis...
  29. Ednrb Regulation of Gastrointestinal Motility
    KENT CHARLES WILLIAMS; Fiscal Year: 2013
    ..implicationsfor HSCR patients and for other patient populations that suffer from gastroesophageal reflux, irritable bowel syndrome, and constipation...
  30. MECHANOTRANSDUCTION IN INTESTINAL SMOOTH MUSCLE CELLS
    Gianrico Farrugia; Fiscal Year: 2013
    ..5 function. We also hypothesize that in a subset of patients with irritable bowel syndrome (IBS), specific mutations in SCN5A result in altered electrophysiology and mechanosensitivity of Nav1...
  31. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William E Whitehead; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Irritable bowel syndrome (IBS) affects 10% of US adults and is associated with significant impairment in quality of life...
  32. Mechanisms of Altered Gastrointestinal Dysfunction
    QiQi Zhou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Patients with irritable bowel syndrome (IBS) suffer from chronic abdominal pain and associated GI symptoms - diarrhea, constipation, bloating &urgency...
  33. Protocol- vs Patient-Oriented TCM Practices: A RCT for IBS Symptom Management
    Joyce K Anastasi; Fiscal Year: 2012
    ..will test the efficacy of Acupuncture/Moxibustion (Acu/Moxa) to improve the symptoms associated with Irritable Bowel Syndrome (IBS)...
  34. Central Molecular Mechanisms of Stress-Induced Visceral Hypersensitivity
    ANTHONY CHRISTOPHER JOHNSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The hallmark symptom of irritable bowel syndrome (IBS), a chronic functional gastrointestinal (GI) disorder, is severe abdominal pain, associated with altered bowel habits, in the absence of any ..
  35. Cross-sensitization in the pelvis and neurogenic bladder
    Anna P Malykhina; Fiscal Year: 2012
    ..is a common symptom of many urologic and gastrointestinal disorders including interstitial cystitis and irritable bowel syndrome. Cross-sensitization among pelvic organs contributes to chronic pelvic pain of unknown etiology...
  36. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael D Gershon; Fiscal Year: 2012
    ..This work is relevant to the pathogenesis and treatment of inflammatory bowel disease, irritable bowel syndrome, and also to the disabling intestinal manifestations of Parkinson's disease. )
  37. Corticotropin-Releasing Factor Action on GI Function
    YVETTE FRANCE TACHE; Fiscal Year: 2012
    ..which are involved in stress response can initiate and aggravate functional bowel diseases, such as irritable bowel syndrome, dyspepsia and cyclic vomiting syndrome...
  38. Symptom management for irritable bowel syndrome constipation (IBS-C)
    Joyce K Anastasi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Irritable Bowel Syndrome (IBS) is a chronic condition which affects 15% to 20% of North Americans...
  39. NEUROCHEMICAL MECHANISMS OF VISCERAL PAIN
    Richard J Traub; Fiscal Year: 2013
    ..In general, women are more sensitive to pain than men and functional bowel disorders, such as irritable bowel syndrome (IBS), are 2-3 times more prevalent in women...
  40. VZV in the enteric nervous system: pathogenesis and consequences
    Michael D Gershon; Fiscal Year: 2013
    ..unsuspected reactivation of VZV in enteric neurons might contribute to the pathogenesis of GI disorders such as irritable bowel syndrome, inflammatory bowel disease, idiopathic gastroparesis, and chronic intestinal pseudoobstruction.
  41. Control of Nociception in the Spinal Cord
    Sukhbir S Mokha; Fiscal Year: 2010
    Many pain syndromes/disorders observed below the head region, such as irritable bowel syndrome (IBS), fibromyalgia, interstitial cystitis (1C), vulvodynia, endometriosis and pelvic pain, have a greater prevalence in women or are female-..
  42. A NURSING STUDY OF GUT FUNCTION IN MENSTRUATING WOMEN
    Margaret McLean Heitkemper; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal (GI) disorder characterized by abdominal pain and alterations in bowel pattern...
  43. Alterations in the human gut microbiome associated with travelers'diarrhea
    BONNIE PATRICIA YOUMANS; Fiscal Year: 2013
    ..Alterations in the GI microbiota have been correlated to diseases such as obesity and irritable bowel syndrome. Secretory diarrhea exhibits alterations on the GI community, and up to 60% of people traveling from ..
  44. Development of a Novel High-Throughput Screening Platform for BK Channel Modulato
    Frank T Horrigan; Fiscal Year: 2013
    ..hypertension, ischemic heart disease, erectile dysfunction, urinary incontinence, gastric hypermotility, irritable bowel syndrome, pancreatitis, cancer (brain, bone, and prostate), rheumatoid arthritis, glaucoma and diabetes...
  45. Novel Mechanisms of Visceral Pain: Functional Properties of Microglia
    Jennifer L Watts; Fiscal Year: 2012
    ..This research will potentially broaden treatment options available for IBD, which may also extend to treatment of functional gastrointestinal disorders like irritable bowel syndrome.
  46. Spinal glia activation in chronic stress-induced visceral hyperalgesia
    Sylvie Bradesi; Fiscal Year: 2013
    ..the visceral pain component of many common functional gastrointestinal disorders (FGID) including irritable bowel syndrome (IBS)...
  47. Mentoring and Research in Placebo Studies, Asian Medicine, and CAM
    Ted Kaptchuk; Fiscal Year: 2013
    ..K24, the principal investigator developed a research portfolio that includes translational research in irritable bowel syndrome, asthma, depression, osteoarthritis, and migraine. These research areas will be expanded...
  48. MOLECULAR MECHANISMS OF RECEPTOR AND CHANNEL FUNCTION
    David Julius; Fiscal Year: 2013
    ..Such information is key to the rational development of therapeutic agents that target chronic inflammatory pain syndromes (e.g. arthritis, irritable bowel syndrome, and asthma) and other disorders involving TRP channels.
  49. Comorbid Chronic Pain Conditions - Mechanisms, Diagnosis and Treatments
    Allen W Cowley; Fiscal Year: 2011
    ..They include: chronic fatigue syndrome, chronic headache, endometriosis, fibromyalgia, irritable bowel syndrome, interstitial cystitis, and vulvodynia...
  50. Structural studies of tight junction proteins
    John M Flanagan; Fiscal Year: 2013
    ..g. brain tumors), stroke, retinopathies, kidney disorders, irritable bowel syndrome, Alzheimer's disease and vascular dementia, and asthma...
  51. GI Barrier and Microbiome Response to VSL3 in Irritable Bowel Syndrome
    Robert Shulman; Fiscal Year: 2012
    ..of age around the world have recurrent abdominal pain and up to 66% of these develop irritable bowel syndrome (IBS) as adults...
  52. Modulation of Colonic Response to Stress by Peripheral CRF2 Receptors
    MILLION MULUGETA; Fiscal Year: 2012
    ..and visceral hypersensitivity will have important clinical implications in functional disorders such as irritable bowel syndrome, where a link between stress, CRF1 signaling pathway and symptoms are increasingly recognized...
  53. Central and Peripheral Autonomic Responses in Irritable Bowel Syndrome
    Kirsten Tillisch; Fiscal Year: 2010
    b>Irritable Bowel Syndrome (IBS) is the most common functional gastrointestinal disorder, leading to significant impact on both patients and society...
  54. Evaluation of sensory neuron plasticity following neonatal maternal separation
    JULIE A CARLSTEN CHRISTIANSON; Fiscal Year: 2011
    ..S and is the main debilitating aspect in irritable bowel syndrome (IBS)...
  55. Cellular mechanisms underlying kappa opioid regulation of stress responses
    Julia C Lemos; Fiscal Year: 2010
    ..There is a broad spectrum of stress related diseases ranging from pathologies such as irritable bowel syndrome to cardiac disease to depression...
  56. The Human Microbiome in Pediatric Abdominal Pain and Intestinal Inflammation
    James Versalovic; Fiscal Year: 2012
    ..In addition to the detailed clinical assessment of healthy children and children with irritable bowel syndrome, constipation, and inflammatory bowel disease (Crohn disease), multiple strategies will be deployed to ..
  57. Phase I: Safety and Tolerance of Lactobactocillus reuteri in Adults
    Jon Marc Rhoads; Fiscal Year: 2011
    ..reuteri. Evidence could identify the early onset of gastrointestinal conditions, such as Irritable Bowel Syndrome. L. reuteri could possibly assist in the prevention of acute diarrhea and allergic disease...
  58. Randomized placebo-controlled trial of glutamine for patients with IBS
    G Nicholas Verne; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is estimated to affect 20% of the US population...
  59. Generating Human Intestinal Organoids with an ENS.
    James M Wells; Fiscal Year: 2013
    ..Common intestinal motility disorders include Irritable Bowel Syndrome and Fecal Incontinence, whereas more rare forms such as Hirschsprung's Disease have a genetic basis ..
  60. Time-resolved measurements of breath hydrogen sulfide
    STEVEN M MASSICK; Fiscal Year: 2010
    ..and propose new research for examining the role of H2S in gastrointestinal illness including colitis, irritable bowel syndrome, and Crohn's disease...
  61. Brain Bladder Interactions in IC/PBS
    LARISSA RODRIGUEZ; Fiscal Year: 2012
    ..part of a larger group of chronic functional pain disorders, which also include such common disorders as irritable bowel syndrome (IBS) and fibromyalgia (FM)...
  62. PROFILING VULVODYNIA BASED ON NEUROBIOLOGICAL AND BEHAVIORAL ENDOPHENOTYPES
    Andrea J Rapkin; Fiscal Year: 2013
    ..matter) brain imaging in VD patients to 200 age-matched female healthy controls (HC), 200 patients with irritable bowel syndrome (IBS) and 100 patients with interstitial cystitis/painful bladder syndrome which are available from a ..
  63. Perception and Modulation of Visceral Sensation
    Emeran A Mayer; Fiscal Year: 2012
    The long-term goal of the proposed research is to better understand the pathophysiology of irritable bowel syndrome (IBS), in the hope to develop more effective treatments...
  64. Is small intestinal bacterial overgrowth associated with functional dyspepsia?
    Henry C Lin; Fiscal Year: 2010
    ..Bloating is a symptom shared with irritable bowel syndrome (IBS), another functional bowel disorder with a prevalence of ~15%...
  65. Development of a LH-PCR Based Diagnostic for Inflammatory Bowel Disease
    Patrick Gillevet; Fiscal Year: 2007
    ..to IBD but also in other areas such as colorectal carcinogenesis, intestinal infections, celiac disease, irritable bowel syndrome, prebiotic and probiotic therapies...
  66. GDNF in the Enteric Nervous System
    Yun Xia; Fiscal Year: 2007
    ..are believed to reflect neuropathic changes in the enteric nervous system that may be manifest as the irritable bowel syndrome (IBS), nonulcer dyspepsia or non-cardiac chest pain...
  67. A Twin Study of Chronic Fatigue Syndrome in Sweden
    Nancy Pedersen; Fiscal Year: 2003
    ..based Swedish Twin Registry for persistent fatigue, several overlapping conditions (fibromyalgia, irritable bowel syndrome, tension headache, allergy/eczema, generalized anxiety disorder, and major depression), and a detailed ..
  68. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..These patients have a condition resembling irritable bowel syndrome (IBS), which we termed the irritable pouch syndrome (IPS)...
  69. BRAIN/PELVIC VISCERA INTERACTIONS IN PSYCHIATRIC DISEASE
    RITA VALENTINO; Fiscal Year: 2001
    ..of mood and anxiety disorders is their frequent coexistence with functional bowel disorders, such as irritable bowel syndrome. Conversely, psychiatric symptoms are prevalent in subjects diagnosed with functional bowel disorders, ..
  70. NORADRENERGIC DYSFUNCTION--A MODEL OF FIBROMYALGIA PAIN
    Luc Jasmin; Fiscal Year: 2001
    ..As such, fibromyalgia overlaps conditions such as Chronic Fatigue Syndrome, Irritable Bowel Syndrome, tension and migraine headaches...