functional colonic diseases

Summary

Summary: Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.

Top Publications

  1. ncbi The challenge of irritable bowel syndrome: creating an alliance between patient and physician
    B Shen
    Department of Gastroenterology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 68:224-5, 229-33, 236-7. 2001
  2. ncbi Neuropathophysiology of irritable bowel syndrome
    Jackie D Wood
    Departments of Physiology and Cell Biology and Internal Medicine, Ohio State University College of Medicine and Public Health, Columbus, Ohio, USA
    J Clin Gastroenterol 35:S11-22. 2002
  3. ncbi Review article: epidemiology and quality of life in functional gastrointestinal disorders
    L Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Aliment Pharmacol Ther 20:31-9. 2004
  4. ncbi The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects
    A P S Hungin
    Centre for Integrated Health Care Research, The Wolfson Research Institute, University of Durham, Stockton on Tees, UK
    Aliment Pharmacol Ther 17:643-50. 2003
  5. ncbi Symptom patterns and relative distribution of functional bowel disorders in 1,023 gastroenterology patients in Iran
    Delnaz Roshandel
    Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Taleghani Hospital, Parvaneh Street, Velenjak, Tehran, Iran
    Int J Colorectal Dis 21:814-25. 2006
  6. ncbi A population-based epidemiologic study of irritable bowel syndrome in South China: stratified randomized study by cluster sampling
    L S Xiong
    Department of Gastroenterology, The First Affiliated Hospital, SunYat sen University, Guangzhou, China
    Aliment Pharmacol Ther 19:1217-24. 2004
  7. ncbi Functional gastrointestinal disorders in Canada: first population-based survey using Rome II criteria with suggestions for improving the questionnaire
    W G Thompson
    University of Ottawa, Ontario, Canada
    Dig Dis Sci 47:225-35. 2002
  8. ncbi Prevalence of irritable bowel syndrome in Hong Kong
    Ambrose Chi Pong Kwan
    The Hong Kong Society of Gastrointestinal Motility, Hong Kong SAR, China
    J Gastroenterol Hepatol 17:1180-6. 2002
  9. ncbi Epidemiology of irritable bowel syndrome in Chinese
    E M C Lau
    Department of Community and Family Medicine The Chinese University of Hong Kong 4 F School of Public Health Prince of Wales Hospital Shatin, N T
    Dig Dis Sci 47:2621-4. 2002
  10. ncbi [An epidemiological and quality of life study of irritable bowel syndrome in Zhejiang province]
    Jian min Si
    Department of Gastroenterology Institution, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China
    Zhonghua Nei Ke Za Zhi 42:34-7. 2003

Research Grants

  1. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
  2. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
  3. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
  4. Abdominal Symptom Phenotypes: Pathways to New Biomarkers
    Robert Shulman; Fiscal Year: 2010
  5. Integrating CAM: Nursing Emphasis
    Margaret Heitkemper; Fiscal Year: 2006
  6. Women's Health Complementary and Alternative Therapies
    Margaret Heitkemper; Fiscal Year: 2004
  7. MULTICENTER TRIAL OF FUNCTIONAL BOWEL DISORDERS
    Douglas Drossman; Fiscal Year: 2001
  8. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2010
  9. PURINERGIC NEUROGENIC MUCOSAL SECRETION
    JACKIE WOOD; Fiscal Year: 2008
  10. BRADYKININ IN ENTERIC NEUROIMMUNE COMMUNICATION
    JACKIE WOOD; Fiscal Year: 2005

Detail Information

Publications196 found, 100 shown here

  1. ncbi The challenge of irritable bowel syndrome: creating an alliance between patient and physician
    B Shen
    Department of Gastroenterology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 68:224-5, 229-33, 236-7. 2001
    ..We describe a stepwise approach to management, including judicious use of invasive tests, and setting realistic treatment goals that address the dominant symptoms, their severity, and psychosocial factors...
  2. ncbi Neuropathophysiology of irritable bowel syndrome
    Jackie D Wood
    Departments of Physiology and Cell Biology and Internal Medicine, Ohio State University College of Medicine and Public Health, Columbus, Ohio, USA
    J Clin Gastroenterol 35:S11-22. 2002
    ..This review details current concepts of the underlying pathophysiology in terms of the physiology of intestinal secretion, motility, nervous control, sensing function, immuno-neural communication, and the brain-gut axis...
  3. ncbi Review article: epidemiology and quality of life in functional gastrointestinal disorders
    L Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Aliment Pharmacol Ther 20:31-9. 2004
    ..The presence of extra-intestinal symptoms appears to have a major if not greater impact on health care visits, excess health care costs and health-related quality of life in patients with functional gastrointestinal disorders...
  4. ncbi The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects
    A P S Hungin
    Centre for Integrated Health Care Research, The Wolfson Research Institute, University of Durham, Stockton on Tees, UK
    Aliment Pharmacol Ther 17:643-50. 2003
    ..To determine the prevalence, symptom pattern and impact of the irritable bowel syndrome, across eight European countries, using a standardized methodology...
  5. ncbi Symptom patterns and relative distribution of functional bowel disorders in 1,023 gastroenterology patients in Iran
    Delnaz Roshandel
    Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Taleghani Hospital, Parvaneh Street, Velenjak, Tehran, Iran
    Int J Colorectal Dis 21:814-25. 2006
    ..There are scanty data on functional bowel disorder (FBD) patterns in Iran. This first-time study tried to provide preliminary data on relative distribution of different types of FBD and their symptom patterns in Iranian patients...
  6. ncbi A population-based epidemiologic study of irritable bowel syndrome in South China: stratified randomized study by cluster sampling
    L S Xiong
    Department of Gastroenterology, The First Affiliated Hospital, SunYat sen University, Guangzhou, China
    Aliment Pharmacol Ther 19:1217-24. 2004
    ..The detailed population-based data on irritable bowel syndrome in South China are lacking...
  7. ncbi Functional gastrointestinal disorders in Canada: first population-based survey using Rome II criteria with suggestions for improving the questionnaire
    W G Thompson
    University of Ottawa, Ontario, Canada
    Dig Dis Sci 47:225-35. 2002
    ..There is substantial agreement between Rome I and Rome II criteria for irritable bowel syndrome. Rome criteria and questionnaire remain works in progress...
  8. ncbi Prevalence of irritable bowel syndrome in Hong Kong
    Ambrose Chi Pong Kwan
    The Hong Kong Society of Gastrointestinal Motility, Hong Kong SAR, China
    J Gastroenterol Hepatol 17:1180-6. 2002
    ..The distribution of diarrhea or constipation-predominant IBS subtypes, the prevalence of bowel symptoms and the predictors of health-care seeking were also studied...
  9. ncbi Epidemiology of irritable bowel syndrome in Chinese
    E M C Lau
    Department of Community and Family Medicine The Chinese University of Hong Kong 4 F School of Public Health Prince of Wales Hospital Shatin, N T
    Dig Dis Sci 47:2621-4. 2002
    ..05 by ANCOVA), and women with IBS had significantly lower mental health scores than controls (P < 0.05 by ANCOVA). In conclusion, IBS is quite prevalent in Hong Kong Chinese, and the QOL of subjects with IBS was significantly affected...
  10. ncbi [An epidemiological and quality of life study of irritable bowel syndrome in Zhejiang province]
    Jian min Si
    Department of Gastroenterology Institution, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China
    Zhonghua Nei Ke Za Zhi 42:34-7. 2003
    ..To evaluate the prevalence and quality of life (QOL)on irritable bowel syndrome (IBS) patients in Zhejiang province, and to evaluate the applying of Chinese version of the SF-36 questionnaire on IBS...
  11. ncbi Systematic review: Abdominal and pelvic surgery in patients with irritable bowel syndrome
    W L Hasler
    Division of Gastroenterology, University of Michigan School of Medicine, Ann Arbor, 48109, USA
    Aliment Pharmacol Ther 17:997-1005. 2003
    ..To systematically review research on the prevalence of abdominal and pelvic surgery in patients with irritable bowel syndrome...
  12. ncbi [The epidemiology of irritable bowel syndrome and functional constipation of Guangzhou residents]
    X Wei
    Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University of Medical Sciencies, Guangzhou 510080, China
    Zhonghua Nei Ke Za Zhi 40:517-20. 2001
    ..2%; constipation predominant: 27.0%; others: 9.8%. CONCLUSION: The prevalence rates of IBS and functional constipation in Guangzhou City were lower than that in west countries...
  13. ncbi Rates of functional bowel disorders among Israeli Bedouins in rural areas compared with those who moved to permanent towns
    Ami D Sperber
    Department of Gastroenterology, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel 84101
    Clin Gastroenterol Hepatol 3:342-8. 2005
    ..The aim was to compare rates of irritable bowel syndrome (IBS) and functional bowel disorders (FBDs) between Israeli Bedouins still living under rural conditions with those in permanent towns...
  14. ncbi Prevalence and correlates of irritable bowel symptoms in a New Zealand birth cohort
    Gil Barbezat
    Department of Medicine, Dunedin School of Medicine, Dunedin, New Zealand
    N Z Med J 115:U220. 2002
    ..To determine the prevalence and correlates of bowel symptoms and the irritable bowel syndrome (IBS) in a birth cohort of young New Zealanders...
  15. pmc The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
    Gut 50:471-4. 2002
    ..Patients with irritable bowel syndrome (IBS) often report significant exacerbation of their IBS symptoms with menses, raising the possibility that IBS patients may respond differently to the menstrual cycle...
  16. ncbi Irritable bowel syndrome subtypes according to bowel habit: revisiting the alternating subtype
    Fermin Mearin
    Institute of Functional and Motor Digestive Disorders, Centro Medico Teknon, C Vilana 12, 08022 Barcelona, Spain
    Eur J Gastroenterol Hepatol 15:165-72. 2003
    ..Disturbed bowel habit, diarrhoea or constipation is a key manifestation of irritable bowel syndrome (IBS). In some patients, diarrhoea and constipation alternate, giving rise to the so-called alternating subtype...
  17. ncbi Symptoms across the menstrual cycle in women with irritable bowel syndrome
    Margaret M Heitkemper
    Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle 98195, USA
    Am J Gastroenterol 98:420-30. 2003
    ....
  18. ncbi [Irritable bowel syndrome. Survey of definitions, differential diagnosis and pathogenesis]
    G Bodemar
    , gastro- och endokrinologkliniken, Universitetssjukhuset,
    Lakartidningen 98:666-71. 2001
    ..More widespread activity in the brain after exposure to stimuli originating from bowel nerves or less inhibition of this stimulation in the brain are possible mechanisms...
  19. pmc A single-blind trial of reflexology for irritable bowel syndrome
    Philip Tovey
    School of Healthcare Studies, University of Leeds
    Br J Gen Pract 52:19-23. 2002
    ..There are currently no studies which address the effectiveness of reflexology for IBS. Despite this, it continues to be advocated and used...
  20. ncbi [Intestinal gas and functional disorders of the gastrointestinal tract]
    J Serra Pueyo
    Servicio de Aparato Digestivo Hospital General Universitario Vall d Hebron Barcelona España
    Gastroenterol Hepatol 26:263-9. 2003
  21. ncbi Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity
    H Monnikes
    Department of Medicine, Division of Hepatology and Gastroenterology, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Dig Dis 19:201-11. 2001
    ..g. the amygdala. Stress-induced activation or sensitization of mucosal mast cells in the GI tract seem to be involved in stress-associated alterations of visceral sensitivity...
  22. ncbi Tegaserod: a new 5-HT4 agonist
    Brian E Lacy
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Gastroenterol 34:27-33. 2002
    ..This article discusses the role of serotonin in gastrointestinal tract physiology, the structure and pharmacokinetic profile of tegaserod, and clinical applications of this new drug...
  23. ncbi Abnormal levels of neuropeptide Y and peptide YY in the colon in irritable bowel syndrome
    Magnus Simren
    Section of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hosptial, Goteborg, Sweden
    Eur J Gastroenterol Hepatol 15:55-62. 2003
    ..To assess the levels of gut peptides involved in gastrointestinal motor, secretory and sensory function in colonic biopsies in irritable bowel syndrome (IBS) patients and healthy controls...
  24. ncbi Management of irritable bowel syndrome
    Anthony J Viera
    Naval Hospital Jacksonville, Jacksonville, Florida, USA
    Am Fam Physician 66:1867-74. 2002
    ..Comorbid conditions such as depression or anxiety should be investigated and treated...
  25. ncbi Diet in the irritable bowel syndrome
    Martin H Floch
    Gastroenterology and Nutrition Section, Norwalk Hospital, Yale University School of Medicine, Norwalk, Connecticut, USA
    J Clin Gastroenterol 35:S45-52. 2002
    ..Although there are few studies to substantiate exact diets, broad dietary plans are recommended for the different symptoms of IBS. In addition, the recent literature on probiotics and prebiotics pertinent to IBS is reviewed...
  26. ncbi Naloxone treatment for irritable bowel syndrome--a randomized controlled trial with an oral formulation
    N D Hawkes
    Department of Gastroenterology, Prince Charles Hospital, Merthyr Tydfil, UK
    Aliment Pharmacol Ther 16:1649-54. 2002
    ..Endorphins play a role in the constipation troubling some patients with irritable bowel syndrome; hence naloxone, an opioid antagonist, may have a therapeutic role...
  27. ncbi No cause for alarm in IBS
    Nicholas Coleman
    Practitioner 246:557. 2002
  28. ncbi Tegaserod for the treatment of constipation-predominant irritable bowel syndrome
    D E Baker
    Drug Information Center, College of Pharmacy, Washington State University, Spokane, WA, USA
    Rev Gastroenterol Disord 1:187-98. 2001
    ..Tegaserod is well tolerated. Diarrhea is the most frequent adverse effect. The diarrhea tends to occur most frequently during the first few months of therapy and decreases with continued administration...
  29. ncbi Dyspepsia, irritable bowel syndrome, and constipation: review and what's new
    M Camilleri
    Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
    Rev Gastroenterol Disord 1:2-17. 2001
    ..Serotonergic and adrenergic agents and neurotrophic factors are among the novel approaches that may have a significant impact on these disorders...
  30. ncbi Irritable bowel syndrome: update on pathogenesis and management
    Osama Alaradi
    Division of Gastroenterology, School of Medicine Mount Sinai Medical Center, University of Miami, Miami, Fla, USA
    Med Princ Pract 11:2-17. 2002
    ..Psychological treatment and antidepressants should be considered when IBS symptoms are severe or refractory or associated with psychological distress and impaired quality of life...
  31. ncbi The rectum: a window to irritable bowel syndrome?
    G Coremans
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, KULeuven, Belgium
    Digestion 65:238-49. 2002
    ..A working group of experts in the field of IBS discussed whether the rectum or the whole colon is the better site to test in IBS patients and provided suggestions for a number of areas where further advances are required...
  32. ncbi Long-term safety of tegaserod in patients with constipation-predominant irritable bowel syndrome
    G Tougas
    Medicine and Gastroenterology, McMaster University Medical Center, Hamilton, Canada
    Aliment Pharmacol Ther 16:1701-8. 2002
    ..Tegaserod is a 5-hydroxytryptamine-4 receptor partial agonist. Oral administration causes gastrointestinal effects resulting in increased gastrointestinal motility and attenuation of visceral sensation...
  33. pmc Sensation and gas dynamics in functional gastrointestinal disorders
    J R Malagelada
    Hospital Universitari Vall d Hebron, Autonomous University of Barcelona, Spain
    Gut 51:i72-5. 2002
    ..The interplay of these mechanisms results in the clinical expression of symptoms...
  34. pmc Role of thyrotrophin releasing hormone and corticotrophin releasing factor in stress related alterations of gastrointestinal motor function
    C Beglinger
    Division of Gastroenterology, University Hospital, 4031 Basel, Switzerland
    Gut 51:i45-9. 2002
    ..The biological actions of these peptides are discussed in relation to the motility changes and pathways involved in their actions...
  35. ncbi Intestinal microflora and oral bacteriotherapy in irritable bowel syndrome
    G Bazzocchi
    Dept of Internal Medicine and Gastroenterology, Bellana Hospital, University of Bologna, Italy
    Dig Liver Dis 34:S48-53. 2002
    ....
  36. ncbi Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds
    Mickael Bouin
    Gastroenterology Unit, Hopital Saint Luc, Universite de Montreal, Montreal, Quebec, Canada
    Gastroenterology 122:1771-7. 2002
    ..The purpose of this study was to assess the sensitivity, specificity, and the predictive values of pain thresholds evaluated by rectal distention using an electronic barostat in patients with or without IBS and in control subjects...
  37. ncbi Investigation and management of constipation
    Michael J Lamparelli
    Department of Colorectal Surgery, St George s Hospital, London
    Clin Med 2:415-20. 2002
  38. ncbi A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammatory bowel disorders from constipation- and diarrhoea-predominant functional bowel disorders
    Andrew P Poullis
    Mayday University Hospital, London Road, Thornton Heath, Surrey CR7 7YE, UK
    Eur J Gastroenterol Hepatol 14:409-12. 2002
    ..C-reactive protein (CRP) is a sensitive marker of systemic inflammation. Levels of CRP are frequently raised in cases of inflammatory bowel disease (IBD). However, using conventional assays, not all cases of IBD have a detectable level...
  39. ncbi Treatment goals in irritable bowel syndrome
    J E Kellow
    Department of Gastroenterology, Royal North Shore Hospital, University of Sydney, NSW, Australia
    Int J Clin Pract 55:546-51. 2001
    ..Recent clinical trials suggest that 5-HT4 receptor partial agonists, in particular, may have the ability to offer multiple symptom relief, without the risk of significant adverse reactions...
  40. pmc Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome
    Y Sagami
    Department of Psychosomatic Medicine, Tohoku University School of Medicine, Sendai, Japan
    Gut 53:958-64. 2004
    ....
  41. ncbi Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses
    S Elsenbruch
    Institute for Medical Psychology, University Clinic of Essen, Germany
    Am J Gastroenterol 96:460-6. 2001
    ..6, p < 0.05). CONCLUSIONS: These findings support the notion that the IBS symptom groups are characterized by different physiological responses to visceral stimuli, and point to a role of autonomic pathways in IBS symptomatology...
  42. ncbi Abnormal predefecatory colonic motor patterns define constipation in obstructed defecation
    Philip G Dinning
    Department of Gastroenterology, The St George Hospital, University of New South Wales, Kogarah, New South Wales, Australia
    Gastroenterology 127:49-56. 2004
    ....
  43. ncbi Simmering innards: Does irritable bowel syndrome have an immunological basis?
    Christopher N Andrews
    Can J Gastroenterol 18:601-3. 2004
  44. ncbi Laparoscopic subtotal colectomy for colonic inertia
    Cliff Sample
    Centre for Minimal Access Surgery, McMaster University, Hamilton, Ontario, Canada
    J Gastrointest Surg 9:803-8. 2005
    ..Laparoscopic subtotal colectomy provides excellent symptom relief in patients with colonic inertia who do not respond to medical measures...
  45. ncbi Functional diarrhea
    Michael J G Farthing
    St George s, University of London, Cranmer Terrace, London, UK
    Curr Gastroenterol Rep 7:350-7. 2005
    ..Prednisolone lacks efficacy, and early results with probiotics and herbal remedies are encouraging but require confirmation by larger trials...
  46. ncbi Functional bowel and anorectal disorders in patients with pelvic organ prolapse and incontinence
    John E Jelovsek
    Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Obstet Gynecol 193:2105-11. 2005
    ....
  47. ncbi Intestinal gas retention in patients with idiopathic slow-transit constipation
    Ana Cristina Hernando-Harder
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3, D 68167, Mannheim, Germany
    Dig Dis Sci 52:2667-75. 2007
    ..In STC, disturbances of intestinal gas dynamics include basal intestinal gas retention, and this is virtually not affected by acute hyperglycemia or duodenal lipids...
  48. ncbi [An epidemiologic study of functional bowel disorders in adolescents in China]
    Hui Qing Zhou
    Department of Gastroenterology, Xinhua Hospital, Medical College of Jiaotong University, Shanghai 200092, China
    Zhonghua Yi Xue Za Zhi 87:657-60. 2007
    ..To explore the most common bowel frequency and the prevalence rates of functional bowel disorders among adolescents in China...
  49. ncbi Constipation
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Clinical and Enteric Neuroscience Translational and Epidemiological Research Program CENTER, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Best Pract Res Clin Gastroenterol 21:709-31. 2007
    ..Functional defaecatory disorders are primarily treated with pelvic floor retraining using biofeedback therapy...
  50. ncbi Rectal irrigation in the management of functional bowel disorders: a review
    Angela Mary Tod
    Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield
    Br J Nurs 16:858-64. 2007
    ....
  51. ncbi Abdominal bloating in employed adults: prevalence, risk factors, and association with other bowel disorders
    Ashok K Tuteja
    George E Wahlen V A Medical Center, and University of Utah, Salt Lake City, Utah, USA
    Am J Gastroenterol 103:1241-8. 2008
    ..AND AIMS: We report on risk factors for bloating, its relationship to physical activity and quality of life (QOL), and its predictive value for functional bowel disorders...
  52. ncbi Anismus: a marker of multi-site functional disorders?
    Michel Bouchoucha
    Laboratory of Digestive Physiology, Hopital Broussais, 96, rue Didot, 75014 Paris, France
    Int J Colorectal Dis 19:374-9. 2004
    ..This study was undertaken to assess the clinical significance of anismus in patients who complain of constipation...
  53. ncbi Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea
    W Y Chey
    Rochester Institute for Digestive Diseases and Sciences, University of Rochester Medical Center, New York 14607, USA
    Am J Gastroenterol 96:1499-506. 2001
    ..Thus, it is suggested that this powerful contraction is one of the causes of abdominal pain. The action of CCK-8 seems to be mediated via the colon enteric nervous system...
  54. ncbi Distal colonic motor activity in four subgroups of patients with irritable bowel syndrome
    S J Cole
    Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London, United Kingdom
    Dig Dis Sci 47:345-55. 2002
    ....
  55. ncbi Tegaserod: a review of its use in the management of irritable bowel syndrome with constipation in women
    Antona J Wagstaff
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 63:1101-20. 2003
    ....
  56. ncbi Diagnosing the patient with abdominal pain and altered bowel habits: is it irritable bowel syndrome?
    Keith B Holten
    Department of Family Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Am Fam Physician 67:2157-62. 2003
    ..If alarm symptoms are present, a full evaluation should be performed (and gastroenterology referral considered), regardless of the patient's age...
  57. ncbi Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases, University of North Carolina at Chapel Hill, 27599 7080, USA
    Gastroenterology 125:19-31. 2003
    ..We also evaluated the amenability of clinically meaningful subgroups to these treatments...
  58. ncbi Coeliac disease presenting with symptoms of irritable bowel syndrome
    B Shahbazkhani
    Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Aliment Pharmacol Ther 18:231-5. 2003
    ..Coeliac disease may easily mimic symptoms which are parts of the criteria used for diagnosing irritable bowel syndrome...
  59. ncbi Recurrent abdominal pain in children: forerunner to adult irritable bowel syndrome?
    Monica Jarrett
    Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, USA
    J Spec Pediatr Nurs 8:81-9. 2003
    ..Review the etiology and pathophysiology of recurrent abdominal pain (RAP) and its potential role as a precursor to irritable bowel syndrome (IBS) in adults...
  60. ncbi Use of acupressure to improve gastrointestinal motility in women after trans-abdominal hysterectomy
    Li Li Chen
    Department of Nursing, China Medical University, Taichung, 404 Taiwan, ROC
    Am J Chin Med 31:781-90. 2003
    ..Patients and their family members can be taught to continue this procedure at home to enhance GI motility in patients who have undergone TAH...
  61. ncbi Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation
    S A Müller-Lissner
    Park Klinik Weissensee, Berlin, Germany
    Aliment Pharmacol Ther 15:1655-66. 2001
    ..To investigate the efficacy and safety of tegaserod, a novel 5-HT(4) receptor partial agonist, in a randomized, double-blind, placebo-controlled, 12-week treatment, multicentre study...
  62. ncbi Brief report: Assessment of children's gastrointestinal symptoms for clinical trials
    Lynn S Walker
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Pediatr Psychol 27:303-7. 2002
    ..To conduct a pilot study evaluating a procedure for assessment of daily symptoms and functioning in pediatric patients...
  63. ncbi [Abdominal bloating: an up-to-date]
    P Ducrotte
    Département d hépatogastroentérologie et de nutrition, CHU de Rouen, 1 rue de Germont, Rouen Cedex, France
    Gastroenterol Clin Biol 33:F94-100. 2009
    ..Probiotics are another promising option. In some centers, a non pharmacological therapeutic approach, mainly based on hypnosis, is discussed...
  64. ncbi [Bowel gases]
    Istvan Pregun
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 149:819-23. 2008
    ..Further clinical studies are needed to clarify the pathophysiologic mechanisms of intestinal gas and this may contribute to the evaluation of optimal therapy...
  65. ncbi Lipid-induced intestinal gas retention in irritable bowel syndrome
    Jordi Serra
    Digestive System Research Unit, Hospital General Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
    Gastroenterology 123:700-6. 2002
    ....
  66. ncbi Presentations of adult celiac disease in a nationwide patient support group
    Robert D Zipser
    Department of Medicine, Harbor UCLA Medical Center, Torrance, California, USA
    Dig Dis Sci 48:761-4. 2003
    ..Initial physician diagnoses were often irritable bowel syndrome (37%), psychological disorders (29%), and fibromyalgia (9%). These initial presentations are similar to those in Europe and often resemble irritable bowel syndrome...
  67. ncbi Functional defecation disorder as a clinical subgroup of chronic constipation: analysis of symptoms and physiological parameters
    Mark T Eltringham
    Wansbeck General Hospital, Ashington, Northumberland, UK
    Scand J Gastroenterol 43:262-9. 2008
    ..The aim of this study was to use cluster analysis and factor analysis of defecatory symptoms and physiological parameters to look for evidence of subgroups in patients with functional constipation...
  68. ncbi Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial
    A Madisch
    Medical Department I, Technical University Hospital, Dresden, Germany
    Aliment Pharmacol Ther 19:271-9. 2004
    ..Herbal medications have been used in many countries for the treatment of patients with irritable bowel syndrome. Controlled data supporting the efficacy of these treatments in patients with irritable bowel syndrome are lacking...
  69. ncbi Respiratory symptoms and pulmonary functional changes in patients with irritable bowel syndrome
    A Yazar
    Department of Internal Medicine, Mersin University Faculty of Medicine, Turkey
    Am J Gastroenterol 96:1511-6. 2001
    ..01). CONCLUSION: We found that the prevalence of asthma was more common in the IBS group than in controls. Our finding supports the speculation that asthma and IBS may share common pathophysiological processes...
  70. ncbi Predictors of conventional and alternative health care seeking for irritable bowel syndrome and functional dyspepsia
    N A Koloski
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 17:841-51. 2003
    ..The drivers of conventional and, especially, alternative health care use for irritable bowel syndrome and functional dyspepsia are not clear...
  71. ncbi [Irritable bowel syndrome in patients under age 55 with dyspeptic syndrome]
    L Bujanda
    Servicio de Digestiva Hospital de San Eloy Baracaldo Vizcaya, Spain
    An Med Interna 20:360-2. 2003
    ..05). The number of diagnostic tests requested was greater in group II. Psychiatric pathology was in turn more common in group II than in group I (20 versus 7%)(p < 0.05)...
  72. ncbi [Functional digestive disorders and the relationship with psychiatric diseases]
    V L Drug
    Facultatea de Medicină Clinica II Medicală Gastroenterologie, Universitatea de Medicină si Farmacie Gr T Popa Iaşi
    Rev Med Chir Soc Med Nat Iasi 107:307-10. 2002
    ..Features related to disease, patient or the environment could influence the medical referral. The aim of the study was to estimate the importance of psychiatric disorders in patients with functional gastrointestinal disorders...
  73. ncbi Differential induction of c-fos expression in brain nuclei by noxious and non-noxious colonic distension: role of afferent C-fibers and 5-HT3 receptors
    Hubert Monnikes
    Department of Internal Medicine, Charite, Humboldt Universitat, Berlin, Germany
    Brain Res 966:253-64. 2003
    ....
  74. ncbi Stoma formation for functional bowel disease
    R P Harris
    Department of Surgery, University Hospital of South Manchester, Manchester, UK
    Colorectal Dis 6:280-4. 2004
    ..To assess the results of stoma formation for functional bowel disease...
  75. ncbi [Diagnosis of functional bowel diseases]
    W Kruis
    Innere Abteilung, Evangelisches Krankenhaus Kalk, Universitat zu Koln
    Praxis (Bern 1994) 96:319-22. 2007
    ..History either confirms a positive diagnosis or initiates some complementary investigations. Redundant and dangerous technical procedures should be avoided in the diagnostic work up...
  76. ncbi AGA technical review on irritable bowel syndrome
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases, University of North Carolina, Chapel Hill, USA
    Gastroenterology 123:2108-31. 2002
  77. ncbi Emerging treatments for irritable bowel syndrome
    Joseph Ahn
    Department of Medicine, Gastroenterology Division, The University of Chicago, Chicago, Illinois, USA
    Expert Opin Pharmacother 3:9-21. 2002
    ..g. fedotozine) several other drugs that act on other ENS receptors are being studied. In spite of significant progress in IBS research, these emerging therapies require more studies before they can be utilised as clinical treatments...
  78. ncbi Long-term treatment of irritable bowel syndrome: results of a randomized controlled trial
    S P Misra
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Q J Med 73:931-9. 1989
    ..We conclude that irritable bowel syndrome is a chronic relapsing disorder and that treatment with a combination of ispaghula husk and propantheline is effective, both in relieving symptoms and in the maintenance of remission...
  79. ncbi Irritable bowel syndrome in patients with dyspepsia: a community-based study in southern Europe
    A M Caballero-Plasencia
    Department of Medicine, School of Medicine, University of Granada, Spain
    Eur J Gastroenterol Hepatol 11:517-22. 1999
    ..This study was intended to determine their prevalence in the general population, and the degree of overlap between these two digestive disorders...
  80. ncbi Alosetron improves quality of life in women with diarrhea-predominant irritable bowel syndrome
    M E Watson
    Global Health Outcomes, Glaxo Wellcome, Research Triangle Park, North Carolina 27709-3398, USA
    Am J Gastroenterol 96:455-9. 2001
    ..CONCLUSIONS: These results in women with diarrhea-predominant IBS demonstrate that alosetron significantly improves health-related quality of life...
  81. pmc Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis
    N S Goncalves
    School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    Infect Immun 69:6651-9. 2001
    ..TNF-alpha is not obligatory for protective immunity to C. rodentium in mice; however, it appears to play some role in downregulating mucosal pathology and Th1 immune responses...
  82. ncbi Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndrome
    P P Humphrey
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, UK
    Aliment Pharmacol Ther 13:31-8. 1999
    ....
  83. ncbi Temporary transverse colostomy vs loop ileostomy in diversion: a case-matched study
    Y Sakai
    Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Surg 136:338-42. 2001
    ..7% vs 1.6%). CONCLUSIONS: Regarding safety, TC and LI should be considered equivalent options for temporary fecal diversion. We recommend further study comparing the 2 procedures with regard to patient perception and quality of life...
  84. ncbi Dexloxiglumide Rotta Research Lab
    Gabor Varga
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest
    Curr Opin Investig Drugs 3:621-6. 2002
    ..In August 2000, Merrill Lynch expected that dexloxiglumide would not be launched until 2004 [379892], and in June 2001, predicted a US filing date in 2003 [413928]...
  85. ncbi [An epidemiological study on the risk factors of irritable bowel syndrome in Zhanjiang, Guangdong province]
    H Ma
    Department of Gastrology, PLA422 Hospital, Zhanjiang 524005, China
    Zhonghua Liu Xing Bing Xue Za Zhi 22:452-4. 2001
    ..CONCLUSION: Our investigation suggested that the six major risk factors mentioned above played important roles in the progression of IBS in Zhanjiang city...
  86. ncbi Acupuncture treatment for irritable bowel syndrome. A double-blind controlled study
    Z Fireman
    Department of Gastroenterology, Hillel Yaffe Medical Center, Hadera, Israel
    Digestion 64:100-3. 2001
    ..This study aimed at exploring the therapeutic value of acupuncture by comparing the responses of irritable bowel syndrome sufferers to true acupuncture versus sham acupuncture in a controlled double-blind study...
  87. ncbi The gut as a neurological organ
    P Holzer
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Wien Klin Wochenschr 113:647-60. 2001
    ..The ENS and extrinsic afferents are hence prime targets for the therapeutic management of gut diseases and for the relief of the pain and discomfort associated with these disorders...
  88. ncbi Trimebutine: mechanism of action, effects on gastrointestinal function and clinical results
    M Delvaux
    Gastroenterology Unit, CHU Rangueil, Toulouse, France
    J Int Med Res 25:225-46. 1997
    ..It is also effective in children presenting with abdominal pain...
  89. ncbi The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients
    E A Mayer
    CURE Digestive Diseases Research Center Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 16:1357-66. 2002
    ....
  90. pmc Comorbid clinical conditions in chronic fatigue: a co-twin control study
    L A Aaron
    Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Gen Intern Med 16:24-31. 2001
    ....
  91. ncbi Irritable bowel syndrome
    S M Turner
    Department of Family Medicine, Oklahoma State University College of Osteopathic Medicine, 1111 W 17th Street, Tulsa, OK 74107 1898, USA
    Curr Rev Pain 4:54-9. 2000
    ..However, further collaboration between scientists and clinicians from multiple disciplines is strongly encouraged...
  92. pmc An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome
    M Simren
    Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Gut 48:20-7. 2001
    ..Visceral hypersensitivity is a feature of the irritable bowel syndrome (IBS). Postprandial symptoms are common in these patients. The effects of nutrients on colonic perception in IBS are incompletely understood...
  93. ncbi [Some problems on standardization of clinical study on functional gastro-intestinal diseases in Chinese medicine]
    Wei An Wang
    Zhongguo Zhong Xi Yi Jie He Za Zhi 24:941-3. 2004
  94. ncbi [How extensively should irritable bowel syndrome be investigated? Expensive bowel sounds in the abdomen]
    M Fliegner-Baia
    Medizinische Klinik, Stadtspital Triemli, Zurich, Schweiz
    MMW Fortschr Med 144:28-33. 2002
    ..An orienting medical history, clinical examination and exclusion of such alarm symptoms as weight loss, general debility and rectal bleeding, must be followed by a rational choice of further diagnostic measures...
  95. ncbi [Irritable bowel syndrome: pathophysiology and (future) treatment options]
    A M P De Schryver
    Universitair Medisch Centrum, afd Gastro enterologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 146:12-7. 2002
    ....
  96. ncbi Is irritable bowel syndrome more likely to be persistent in those with relatives who suffer from gastrointestinal symptoms? A population-based study at three time points
    J S Kalantar
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 17:1389-97. 2003
    ..We tested the hypothesis that subjects with relatives who suffered from abdominal pain or bowel dysfunction would be at an increased risk of more persistent irritable bowel syndrome...
  97. ncbi The use of endoscopy in patients with gastrointestinal motility problems
    R Sander
    First Medical Department, Municipal Hospital Harlaching, Teaching Hospital of the LM University, Munchen, Germany
    J Clin Gastroenterol 33:185-90. 2001
    ..g., GERD). Furthermore, endoscopic interventional procedures offer sufficient treatment of several motility-related disorders (e.g., achalasia, GERD, its associated diseases, secondary constipation)...
  98. pmc Prevalence of gastrointestinal diseases in two British national birth cohorts
    A G C Ehlin
    Enheten för Klinisk Epidemiologi, Institutionen för medicin vid Karolinska Sjukhuset, Karolinska Institutet, Stockholm, Sweden
    Gut 52:1117-21. 2003
    ..Few studies have investigated the prevalence of multiple gastrointestinal diseases in the general British population...
  99. ncbi Functional brain imaging in irritable bowel syndrome with rectal balloon-distention by using fMRI
    Yao Zong Yuan
    Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    World J Gastroenterol 9:1356-60. 2003
    ....
  100. ncbi Psychopathology in irritable bowel syndrome: support for a psychophysiological model
    Mark A Sykes
    Department of Psychology, Center for Stress and Anxiety Disorders, University at Albany, State University of New York, 1535 Western Avenue, Albany, New York 12203, USA
    J Behav Med 26:361-72. 2003
    ..Anxiety disorders were the most likely disorder to develop before IBS. These results support the theory that psychiatric symptoms, especially anxiety, play a role in the development of IBS...
  101. ncbi Lower gastrointestinal disease in women
    R P Smith
    Department of Obstetrics and Gynecology, Truman Medical Center, University of Missouri at Kansas City, Kansas City, Missouri, USA
    Obstet Gynecol Clin North Am 28:351-61, viii. 2001
    ..A new understanding of the underlying pathophysiology of the most common condition, irritable bowel syndrome, is changing both diagnosis and therapy...

Research Grants30

  1. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  2. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  3. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  4. Abdominal Symptom Phenotypes: Pathways to New Biomarkers
    Robert Shulman; Fiscal Year: 2010
    ..New biomarkers (video capsule endoscopy, lymphocyte activation/cytokine diffuse noxious inhibitory control testing) will be used with newly recruited IBS and control subjects. ..
  5. Integrating CAM: Nursing Emphasis
    Margaret Heitkemper; Fiscal Year: 2006
    ..abstract_text> ..
  6. Women's Health Complementary and Alternative Therapies
    Margaret Heitkemper; Fiscal Year: 2004
    ..abstract_text> ..
  7. MULTICENTER TRIAL OF FUNCTIONAL BOWEL DISORDERS
    Douglas Drossman; Fiscal Year: 2001
    ....
  8. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2010
    ..abstract_text> ..
  9. PURINERGIC NEUROGENIC MUCOSAL SECRETION
    JACKIE WOOD; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  10. BRADYKININ IN ENTERIC NEUROIMMUNE COMMUNICATION
    JACKIE WOOD; Fiscal Year: 2005
    ..The overall goal of the study is to better understand the role of bradykinin in motility disturbances, diarrhea, abdominal pain and inflammation. ..
  11. TRIP for postpartum depression (TRIPPD)
    Barbara Yawn; Fiscal Year: 2009
    ..Equally importantly, it will provide information necessary to translate this evidence into 9eneral primary care practices. ..
  12. EVALUATION OF CHD IN MEN AND WOMEN PRIOR TO FIRST AMI
    Barbara Yawn; Fiscal Year: 2002
    ..In addition, we will provide specific information on current gender-related practice patterns. This information can be used to inform future practice recommendations. ..
  13. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
    ..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
  14. Treatment of Fear and Pain in Irritable Bowel Syndrome
    Bruce Naliboff; Fiscal Year: 2006
    ..abstract_text> ..
  15. NK CELL ACTIVITY AND IBS ACROSS THE MENSTRUAL CYCLE
    Sandra Motzer; Fiscal Year: 2002
    ..abstract_text> ..
  16. SIMPLE VERTEBRATE AND INVERTEBRATE SYSTEMS
    Michael Gershon; Fiscal Year: 2005
    ..Almost all trainees have continued to be productive in biomedical science and some have acquired leadership positions. ..
  17. Colon Polyp Screening with Colonoscopy in Women
    Philip Schoenfeld; Fiscal Year: 2005
    ..Ultimately, the proposed research studies, didactic coursework, and mentoring hopefully will lead to successful R01 applications. ..
  18. COMPLEMENTATION ASSAY TO SCREEN FOR KINASE INHIBITORS
    RICHARD EGLEN; Fiscal Year: 2004
    ..abstract_text> ..
  19. Alcohol, iNOS upregulation, leaky gut & liver disease
    Ali Keshavarzian; Fiscal Year: 2009
    ..Significance: Showing that ALD requires a leaky gut, &that NO &cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test);2) lead to therapies to prevent LD in those drinkers unable to abstain. ..
  20. Psychosocial Intervention for Children with IBD
    Rona L Levy; Fiscal Year: 2010
    ..Results may lead to innovative interventions for IBD and other chronic childhood medical conditions. ..
  21. Neurobiol mechanism/acupuncture therapy/alcoholism
    Jiang Hong Ye; Fiscal Year: 2004
    ..This new knowledge will have a major impact on our understanding of how acupuncture works. The application of this knowledge is expected to improve the effectiveness of acupuncture treatment in alcohol addiction. ..
  22. Complementation Assay for GPCR Desensitization
    RICHARD EGLEN; Fiscal Year: 2003
    ..Furthermore, these assays could have a broader role in drug discovery by identifying agonists at the large population of orphan GPCRs since stimulation of all GPCRs causes BARK and B-arrestin translocation. ..
  23. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  24. Trafficking of Channels Measured by EFC
    RICHARD EGLEN; Fiscal Year: 2004
    ..These initial studies will form the foundation of future phase II SBIR studies to develop EFC into a HTS assay for ICC transport for use by bioteclmology and pharmaceutical companies for drug discovery. ..
  25. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  26. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
  27. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  28. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  29. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....