functional colonic diseases
Summary: Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
Publications196 found, 100 shown here
- The challenge of irritable bowel syndrome: creating an alliance between patient and physicianB Shen
Department of Gastroenterology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 68:224-5, 229-33, 236-7. 2001..We describe a stepwise approach to management, including judicious use of invasive tests, and setting realistic treatment goals that address the dominant symptoms, their severity, and psychosocial factors...
- Neuropathophysiology of irritable bowel syndromeJackie D Wood
Departments of Physiology and Cell Biology and Internal Medicine, Ohio State University College of Medicine and Public Health, Columbus, Ohio, USA
J Clin Gastroenterol 35:S11-22. 2002..This review details current concepts of the underlying pathophysiology in terms of the physiology of intestinal secretion, motility, nervous control, sensing function, immuno-neural communication, and the brain-gut axis...
- Review article: epidemiology and quality of life in functional gastrointestinal disordersL Chang
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Aliment Pharmacol Ther 20:31-9. 2004..The presence of extra-intestinal symptoms appears to have a major if not greater impact on health care visits, excess health care costs and health-related quality of life in patients with functional gastrointestinal disorders...
- The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjectsA P S Hungin
Centre for Integrated Health Care Research, The Wolfson Research Institute, University of Durham, Stockton on Tees, UK
Aliment Pharmacol Ther 17:643-50. 2003..To determine the prevalence, symptom pattern and impact of the irritable bowel syndrome, across eight European countries, using a standardized methodology...
- Symptom patterns and relative distribution of functional bowel disorders in 1,023 gastroenterology patients in IranDelnaz Roshandel
Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Taleghani Hospital, Parvaneh Street, Velenjak, Tehran, Iran
Int J Colorectal Dis 21:814-25. 2006..There are scanty data on functional bowel disorder (FBD) patterns in Iran. This first-time study tried to provide preliminary data on relative distribution of different types of FBD and their symptom patterns in Iranian patients...
- A population-based epidemiologic study of irritable bowel syndrome in South China: stratified randomized study by cluster samplingL S Xiong
Department of Gastroenterology, The First Affiliated Hospital, SunYat sen University, Guangzhou, China
Aliment Pharmacol Ther 19:1217-24. 2004..The detailed population-based data on irritable bowel syndrome in South China are lacking...
- Functional gastrointestinal disorders in Canada: first population-based survey using Rome II criteria with suggestions for improving the questionnaireW G Thompson
University of Ottawa, Ontario, Canada
Dig Dis Sci 47:225-35. 2002..There is substantial agreement between Rome I and Rome II criteria for irritable bowel syndrome. Rome criteria and questionnaire remain works in progress...
- Prevalence of irritable bowel syndrome in Hong KongAmbrose Chi Pong Kwan
The Hong Kong Society of Gastrointestinal Motility, Hong Kong SAR, China
J Gastroenterol Hepatol 17:1180-6. 2002..The distribution of diarrhea or constipation-predominant IBS subtypes, the prevalence of bowel symptoms and the predictors of health-care seeking were also studied...
- Epidemiology of irritable bowel syndrome in ChineseE M C Lau
Department of Community and Family Medicine The Chinese University of Hong Kong 4 F School of Public Health Prince of Wales Hospital Shatin, N T
Dig Dis Sci 47:2621-4. 2002..05 by ANCOVA), and women with IBS had significantly lower mental health scores than controls (P < 0.05 by ANCOVA). In conclusion, IBS is quite prevalent in Hong Kong Chinese, and the QOL of subjects with IBS was significantly affected...
- [An epidemiological and quality of life study of irritable bowel syndrome in Zhejiang province]Jian min Si
Department of Gastroenterology Institution, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China
Zhonghua Nei Ke Za Zhi 42:34-7. 2003..To evaluate the prevalence and quality of life (QOL)on irritable bowel syndrome (IBS) patients in Zhejiang province, and to evaluate the applying of Chinese version of the SF-36 questionnaire on IBS...
- Systematic review: Abdominal and pelvic surgery in patients with irritable bowel syndromeW L Hasler
Division of Gastroenterology, University of Michigan School of Medicine, Ann Arbor, 48109, USA
Aliment Pharmacol Ther 17:997-1005. 2003..To systematically review research on the prevalence of abdominal and pelvic surgery in patients with irritable bowel syndrome...
- [The epidemiology of irritable bowel syndrome and functional constipation of Guangzhou residents]X Wei
Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University of Medical Sciencies, Guangzhou 510080, China
Zhonghua Nei Ke Za Zhi 40:517-20. 2001..2%; constipation predominant: 27.0%; others: 9.8%. CONCLUSION: The prevalence rates of IBS and functional constipation in Guangzhou City were lower than that in west countries...
- Rates of functional bowel disorders among Israeli Bedouins in rural areas compared with those who moved to permanent townsAmi D Sperber
Department of Gastroenterology, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel 84101
Clin Gastroenterol Hepatol 3:342-8. 2005..The aim was to compare rates of irritable bowel syndrome (IBS) and functional bowel disorders (FBDs) between Israeli Bedouins still living under rural conditions with those in permanent towns...
- Prevalence and correlates of irritable bowel symptoms in a New Zealand birth cohortGil Barbezat
Department of Medicine, Dunedin School of Medicine, Dunedin, New Zealand
N Z Med J 115:U220. 2002..To determine the prevalence and correlates of bowel symptoms and the irritable bowel syndrome (IBS) in a birth cohort of young New Zealanders...
- The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteersL A Houghton
Department of Medicine, University Hospital of South Manchester, Manchester M20 2LR, UK
Gut 50:471-4. 2002..Patients with irritable bowel syndrome (IBS) often report significant exacerbation of their IBS symptoms with menses, raising the possibility that IBS patients may respond differently to the menstrual cycle...
- Irritable bowel syndrome subtypes according to bowel habit: revisiting the alternating subtypeFermin Mearin
Institute of Functional and Motor Digestive Disorders, Centro Medico Teknon, C Vilana 12, 08022 Barcelona, Spain
Eur J Gastroenterol Hepatol 15:165-72. 2003..Disturbed bowel habit, diarrhoea or constipation is a key manifestation of irritable bowel syndrome (IBS). In some patients, diarrhoea and constipation alternate, giving rise to the so-called alternating subtype...
- Symptoms across the menstrual cycle in women with irritable bowel syndromeMargaret M Heitkemper
Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle 98195, USA
Am J Gastroenterol 98:420-30. 2003....
- [Irritable bowel syndrome. Survey of definitions, differential diagnosis and pathogenesis]G Bodemar
, gastro- och endokrinologkliniken, Universitetssjukhuset,
Lakartidningen 98:666-71. 2001..More widespread activity in the brain after exposure to stimuli originating from bowel nerves or less inhibition of this stimulation in the brain are possible mechanisms...
- A single-blind trial of reflexology for irritable bowel syndromePhilip Tovey
School of Healthcare Studies, University of Leeds
Br J Gen Pract 52:19-23. 2002..There are currently no studies which address the effectiveness of reflexology for IBS. Despite this, it continues to be advocated and used...
- [Intestinal gas and functional disorders of the gastrointestinal tract]J Serra Pueyo
Servicio de Aparato Digestivo Hospital General Universitario Vall d Hebron Barcelona España
Gastroenterol Hepatol 26:263-9. 2003
- Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivityH Monnikes
Department of Medicine, Division of Hepatology and Gastroenterology, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
Dig Dis 19:201-11. 2001..g. the amygdala. Stress-induced activation or sensitization of mucosal mast cells in the GI tract seem to be involved in stress-associated alterations of visceral sensitivity...
- Tegaserod: a new 5-HT4 agonistBrian E Lacy
Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Clin Gastroenterol 34:27-33. 2002..This article discusses the role of serotonin in gastrointestinal tract physiology, the structure and pharmacokinetic profile of tegaserod, and clinical applications of this new drug...
- Abnormal levels of neuropeptide Y and peptide YY in the colon in irritable bowel syndromeMagnus Simren
Section of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hosptial, Goteborg, Sweden
Eur J Gastroenterol Hepatol 15:55-62. 2003..To assess the levels of gut peptides involved in gastrointestinal motor, secretory and sensory function in colonic biopsies in irritable bowel syndrome (IBS) patients and healthy controls...
- Management of irritable bowel syndromeAnthony J Viera
Naval Hospital Jacksonville, Jacksonville, Florida, USA
Am Fam Physician 66:1867-74. 2002..Comorbid conditions such as depression or anxiety should be investigated and treated...
- Diet in the irritable bowel syndromeMartin H Floch
Gastroenterology and Nutrition Section, Norwalk Hospital, Yale University School of Medicine, Norwalk, Connecticut, USA
J Clin Gastroenterol 35:S45-52. 2002..Although there are few studies to substantiate exact diets, broad dietary plans are recommended for the different symptoms of IBS. In addition, the recent literature on probiotics and prebiotics pertinent to IBS is reviewed...
- Naloxone treatment for irritable bowel syndrome--a randomized controlled trial with an oral formulationN D Hawkes
Department of Gastroenterology, Prince Charles Hospital, Merthyr Tydfil, UK
Aliment Pharmacol Ther 16:1649-54. 2002..Endorphins play a role in the constipation troubling some patients with irritable bowel syndrome; hence naloxone, an opioid antagonist, may have a therapeutic role...
- No cause for alarm in IBSNicholas Coleman
Practitioner 246:557. 2002
- Tegaserod for the treatment of constipation-predominant irritable bowel syndromeD E Baker
Drug Information Center, College of Pharmacy, Washington State University, Spokane, WA, USA
Rev Gastroenterol Disord 1:187-98. 2001..Tegaserod is well tolerated. Diarrhea is the most frequent adverse effect. The diarrhea tends to occur most frequently during the first few months of therapy and decreases with continued administration...
- Dyspepsia, irritable bowel syndrome, and constipation: review and what's newM Camilleri
Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
Rev Gastroenterol Disord 1:2-17. 2001..Serotonergic and adrenergic agents and neurotrophic factors are among the novel approaches that may have a significant impact on these disorders...
- Irritable bowel syndrome: update on pathogenesis and managementOsama Alaradi
Division of Gastroenterology, School of Medicine Mount Sinai Medical Center, University of Miami, Miami, Fla, USA
Med Princ Pract 11:2-17. 2002..Psychological treatment and antidepressants should be considered when IBS symptoms are severe or refractory or associated with psychological distress and impaired quality of life...
- The rectum: a window to irritable bowel syndrome?G Coremans
Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, KULeuven, Belgium
Digestion 65:238-49. 2002..A working group of experts in the field of IBS discussed whether the rectum or the whole colon is the better site to test in IBS patients and provided suggestions for a number of areas where further advances are required...
- Long-term safety of tegaserod in patients with constipation-predominant irritable bowel syndromeG Tougas
Medicine and Gastroenterology, McMaster University Medical Center, Hamilton, Canada
Aliment Pharmacol Ther 16:1701-8. 2002..Tegaserod is a 5-hydroxytryptamine-4 receptor partial agonist. Oral administration causes gastrointestinal effects resulting in increased gastrointestinal motility and attenuation of visceral sensation...
- Sensation and gas dynamics in functional gastrointestinal disordersJ R Malagelada
Hospital Universitari Vall d Hebron, Autonomous University of Barcelona, Spain
Gut 51:i72-5. 2002..The interplay of these mechanisms results in the clinical expression of symptoms...
- Role of thyrotrophin releasing hormone and corticotrophin releasing factor in stress related alterations of gastrointestinal motor functionC Beglinger
Division of Gastroenterology, University Hospital, 4031 Basel, Switzerland
Gut 51:i45-9. 2002..The biological actions of these peptides are discussed in relation to the motility changes and pathways involved in their actions...
- Intestinal microflora and oral bacteriotherapy in irritable bowel syndromeG Bazzocchi
Dept of Internal Medicine and Gastroenterology, Bellana Hospital, University of Bologna, Italy
Dig Liver Dis 34:S48-53. 2002....
- Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholdsMickael Bouin
Gastroenterology Unit, Hopital Saint Luc, Universite de Montreal, Montreal, Quebec, Canada
Gastroenterology 122:1771-7. 2002..The purpose of this study was to assess the sensitivity, specificity, and the predictive values of pain thresholds evaluated by rectal distention using an electronic barostat in patients with or without IBS and in control subjects...
- Investigation and management of constipationMichael J Lamparelli
Department of Colorectal Surgery, St George s Hospital, London
Clin Med 2:415-20. 2002
- A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammatory bowel disorders from constipation- and diarrhoea-predominant functional bowel disordersAndrew P Poullis
Mayday University Hospital, London Road, Thornton Heath, Surrey CR7 7YE, UK
Eur J Gastroenterol Hepatol 14:409-12. 2002..C-reactive protein (CRP) is a sensitive marker of systemic inflammation. Levels of CRP are frequently raised in cases of inflammatory bowel disease (IBD). However, using conventional assays, not all cases of IBD have a detectable level...
- Treatment goals in irritable bowel syndromeJ E Kellow
Department of Gastroenterology, Royal North Shore Hospital, University of Sydney, NSW, Australia
Int J Clin Pract 55:546-51. 2001..Recent clinical trials suggest that 5-HT4 receptor partial agonists, in particular, may have the ability to offer multiple symptom relief, without the risk of significant adverse reactions...
- Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndromeY Sagami
Department of Psychosomatic Medicine, Tohoku University School of Medicine, Sendai, Japan
Gut 53:958-64. 2004....
- Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responsesS Elsenbruch
Institute for Medical Psychology, University Clinic of Essen, Germany
Am J Gastroenterol 96:460-6. 2001..6, p < 0.05). CONCLUSIONS: These findings support the notion that the IBS symptom groups are characterized by different physiological responses to visceral stimuli, and point to a role of autonomic pathways in IBS symptomatology...
- Abnormal predefecatory colonic motor patterns define constipation in obstructed defecationPhilip G Dinning
Department of Gastroenterology, The St George Hospital, University of New South Wales, Kogarah, New South Wales, Australia
Gastroenterology 127:49-56. 2004....
- Simmering innards: Does irritable bowel syndrome have an immunological basis?Christopher N Andrews
Can J Gastroenterol 18:601-3. 2004
- Laparoscopic subtotal colectomy for colonic inertiaCliff Sample
Centre for Minimal Access Surgery, McMaster University, Hamilton, Ontario, Canada
J Gastrointest Surg 9:803-8. 2005..Laparoscopic subtotal colectomy provides excellent symptom relief in patients with colonic inertia who do not respond to medical measures...
- Functional diarrheaMichael J G Farthing
St George s, University of London, Cranmer Terrace, London, UK
Curr Gastroenterol Rep 7:350-7. 2005..Prednisolone lacks efficacy, and early results with probiotics and herbal remedies are encouraging but require confirmation by larger trials...
- Functional bowel and anorectal disorders in patients with pelvic organ prolapse and incontinenceJohn E Jelovsek
Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am J Obstet Gynecol 193:2105-11. 2005....
- Intestinal gas retention in patients with idiopathic slow-transit constipationAna Cristina Hernando-Harder
Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3, D 68167, Mannheim, Germany
Dig Dis Sci 52:2667-75. 2007..In STC, disturbances of intestinal gas dynamics include basal intestinal gas retention, and this is virtually not affected by acute hyperglycemia or duodenal lipids...
- [An epidemiologic study of functional bowel disorders in adolescents in China]Hui Qing Zhou
Department of Gastroenterology, Xinhua Hospital, Medical College of Jiaotong University, Shanghai 200092, China
Zhonghua Yi Xue Za Zhi 87:657-60. 2007..To explore the most common bowel frequency and the prevalence rates of functional bowel disorders among adolescents in China...
- ConstipationAdil E Bharucha
Division of Gastroenterology and Hepatology, Clinical and Enteric Neuroscience Translational and Epidemiological Research Program CENTER, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Best Pract Res Clin Gastroenterol 21:709-31. 2007..Functional defaecatory disorders are primarily treated with pelvic floor retraining using biofeedback therapy...
- Rectal irrigation in the management of functional bowel disorders: a reviewAngela Mary Tod
Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield
Br J Nurs 16:858-64. 2007....
- Abdominal bloating in employed adults: prevalence, risk factors, and association with other bowel disordersAshok K Tuteja
George E Wahlen V A Medical Center, and University of Utah, Salt Lake City, Utah, USA
Am J Gastroenterol 103:1241-8. 2008..AND AIMS: We report on risk factors for bloating, its relationship to physical activity and quality of life (QOL), and its predictive value for functional bowel disorders...
- Anismus: a marker of multi-site functional disorders?Michel Bouchoucha
Laboratory of Digestive Physiology, Hopital Broussais, 96, rue Didot, 75014 Paris, France
Int J Colorectal Dis 19:374-9. 2004..This study was undertaken to assess the clinical significance of anismus in patients who complain of constipation...
- Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrheaW Y Chey
Rochester Institute for Digestive Diseases and Sciences, University of Rochester Medical Center, New York 14607, USA
Am J Gastroenterol 96:1499-506. 2001..Thus, it is suggested that this powerful contraction is one of the causes of abdominal pain. The action of CCK-8 seems to be mediated via the colon enteric nervous system...
- Distal colonic motor activity in four subgroups of patients with irritable bowel syndromeS J Cole
Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London, United Kingdom
Dig Dis Sci 47:345-55. 2002....
- Tegaserod: a review of its use in the management of irritable bowel syndrome with constipation in womenAntona J Wagstaff
Adis International Limited, Mairangi Bay, Auckland, New Zealand
Drugs 63:1101-20. 2003....
- Diagnosing the patient with abdominal pain and altered bowel habits: is it irritable bowel syndrome?Keith B Holten
Department of Family Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Am Fam Physician 67:2157-62. 2003..If alarm symptoms are present, a full evaluation should be performed (and gastroenterology referral considered), regardless of the patient's age...
- Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disordersDouglas A Drossman
UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases, University of North Carolina at Chapel Hill, 27599 7080, USA
Gastroenterology 125:19-31. 2003..We also evaluated the amenability of clinically meaningful subgroups to these treatments...
- Coeliac disease presenting with symptoms of irritable bowel syndromeB Shahbazkhani
Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
Aliment Pharmacol Ther 18:231-5. 2003..Coeliac disease may easily mimic symptoms which are parts of the criteria used for diagnosing irritable bowel syndrome...
- Recurrent abdominal pain in children: forerunner to adult irritable bowel syndrome?Monica Jarrett
Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, USA
J Spec Pediatr Nurs 8:81-9. 2003..Review the etiology and pathophysiology of recurrent abdominal pain (RAP) and its potential role as a precursor to irritable bowel syndrome (IBS) in adults...
- Use of acupressure to improve gastrointestinal motility in women after trans-abdominal hysterectomyLi Li Chen
Department of Nursing, China Medical University, Taichung, 404 Taiwan, ROC
Am J Chin Med 31:781-90. 2003..Patients and their family members can be taught to continue this procedure at home to enhance GI motility in patients who have undergone TAH...
- Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipationS A Müller-Lissner
Park Klinik Weissensee, Berlin, Germany
Aliment Pharmacol Ther 15:1655-66. 2001..To investigate the efficacy and safety of tegaserod, a novel 5-HT(4) receptor partial agonist, in a randomized, double-blind, placebo-controlled, 12-week treatment, multicentre study...
- Brief report: Assessment of children's gastrointestinal symptoms for clinical trialsLynn S Walker
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Pediatr Psychol 27:303-7. 2002..To conduct a pilot study evaluating a procedure for assessment of daily symptoms and functioning in pediatric patients...
- [Abdominal bloating: an up-to-date]P Ducrotte
Département d hépatogastroentérologie et de nutrition, CHU de Rouen, 1 rue de Germont, Rouen Cedex, France
Gastroenterol Clin Biol 33:F94-100. 2009..Probiotics are another promising option. In some centers, a non pharmacological therapeutic approach, mainly based on hypnosis, is discussed...
- [Bowel gases]Istvan Pregun
Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
Orv Hetil 149:819-23. 2008..Further clinical studies are needed to clarify the pathophysiologic mechanisms of intestinal gas and this may contribute to the evaluation of optimal therapy...
- Lipid-induced intestinal gas retention in irritable bowel syndromeJordi Serra
Digestive System Research Unit, Hospital General Vall d Hebron, Autonomous University of Barcelona, Barcelona, Spain
Gastroenterology 123:700-6. 2002....
- Presentations of adult celiac disease in a nationwide patient support groupRobert D Zipser
Department of Medicine, Harbor UCLA Medical Center, Torrance, California, USA
Dig Dis Sci 48:761-4. 2003..Initial physician diagnoses were often irritable bowel syndrome (37%), psychological disorders (29%), and fibromyalgia (9%). These initial presentations are similar to those in Europe and often resemble irritable bowel syndrome...
- Functional defecation disorder as a clinical subgroup of chronic constipation: analysis of symptoms and physiological parametersMark T Eltringham
Wansbeck General Hospital, Ashington, Northumberland, UK
Scand J Gastroenterol 43:262-9. 2008..The aim of this study was to use cluster analysis and factor analysis of defecatory symptoms and physiological parameters to look for evidence of subgroups in patients with functional constipation...
- Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trialA Madisch
Medical Department I, Technical University Hospital, Dresden, Germany
Aliment Pharmacol Ther 19:271-9. 2004..Herbal medications have been used in many countries for the treatment of patients with irritable bowel syndrome. Controlled data supporting the efficacy of these treatments in patients with irritable bowel syndrome are lacking...
- Respiratory symptoms and pulmonary functional changes in patients with irritable bowel syndromeA Yazar
Department of Internal Medicine, Mersin University Faculty of Medicine, Turkey
Am J Gastroenterol 96:1511-6. 2001..01). CONCLUSION: We found that the prevalence of asthma was more common in the IBS group than in controls. Our finding supports the speculation that asthma and IBS may share common pathophysiological processes...
- Predictors of conventional and alternative health care seeking for irritable bowel syndrome and functional dyspepsiaN A Koloski
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 17:841-51. 2003..The drivers of conventional and, especially, alternative health care use for irritable bowel syndrome and functional dyspepsia are not clear...
- [Irritable bowel syndrome in patients under age 55 with dyspeptic syndrome]L Bujanda
Servicio de Digestiva Hospital de San Eloy Baracaldo Vizcaya, Spain
An Med Interna 20:360-2. 2003..05). The number of diagnostic tests requested was greater in group II. Psychiatric pathology was in turn more common in group II than in group I (20 versus 7%)(p < 0.05)...
- [Functional digestive disorders and the relationship with psychiatric diseases]V L Drug
Facultatea de Medicină Clinica II Medicală Gastroenterologie, Universitatea de Medicină si Farmacie Gr T Popa Iaşi
Rev Med Chir Soc Med Nat Iasi 107:307-10. 2002..Features related to disease, patient or the environment could influence the medical referral. The aim of the study was to estimate the importance of psychiatric disorders in patients with functional gastrointestinal disorders...
- Differential induction of c-fos expression in brain nuclei by noxious and non-noxious colonic distension: role of afferent C-fibers and 5-HT3 receptorsHubert Monnikes
Department of Internal Medicine, Charite, Humboldt Universitat, Berlin, Germany
Brain Res 966:253-64. 2003....
- Stoma formation for functional bowel diseaseR P Harris
Department of Surgery, University Hospital of South Manchester, Manchester, UK
Colorectal Dis 6:280-4. 2004..To assess the results of stoma formation for functional bowel disease...
- [Diagnosis of functional bowel diseases]W Kruis
Innere Abteilung, Evangelisches Krankenhaus Kalk, Universitat zu Koln
Praxis (Bern 1994) 96:319-22. 2007..History either confirms a positive diagnosis or initiates some complementary investigations. Redundant and dangerous technical procedures should be avoided in the diagnostic work up...
- AGA technical review on irritable bowel syndromeDouglas A Drossman
UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases, University of North Carolina, Chapel Hill, USA
Gastroenterology 123:2108-31. 2002
- Emerging treatments for irritable bowel syndromeJoseph Ahn
Department of Medicine, Gastroenterology Division, The University of Chicago, Chicago, Illinois, USA
Expert Opin Pharmacother 3:9-21. 2002..g. fedotozine) several other drugs that act on other ENS receptors are being studied. In spite of significant progress in IBS research, these emerging therapies require more studies before they can be utilised as clinical treatments...
- Long-term treatment of irritable bowel syndrome: results of a randomized controlled trialS P Misra
Department of Gastroenterology, G B Pant Hospital, New Delhi, India
Q J Med 73:931-9. 1989..We conclude that irritable bowel syndrome is a chronic relapsing disorder and that treatment with a combination of ispaghula husk and propantheline is effective, both in relieving symptoms and in the maintenance of remission...
- Irritable bowel syndrome in patients with dyspepsia: a community-based study in southern EuropeA M Caballero-Plasencia
Department of Medicine, School of Medicine, University of Granada, Spain
Eur J Gastroenterol Hepatol 11:517-22. 1999..This study was intended to determine their prevalence in the general population, and the degree of overlap between these two digestive disorders...
- Alosetron improves quality of life in women with diarrhea-predominant irritable bowel syndromeM E Watson
Global Health Outcomes, Glaxo Wellcome, Research Triangle Park, North Carolina 27709-3398, USA
Am J Gastroenterol 96:455-9. 2001..CONCLUSIONS: These results in women with diarrhea-predominant IBS demonstrate that alosetron significantly improves health-related quality of life...
- Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitisN S Goncalves
School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
Infect Immun 69:6651-9. 2001..TNF-alpha is not obligatory for protective immunity to C. rodentium in mice; however, it appears to play some role in downregulating mucosal pathology and Th1 immune responses...
- Review article: the therapeutic potential of 5-HT3 receptor antagonists in the treatment of irritable bowel syndromeP P Humphrey
Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, UK
Aliment Pharmacol Ther 13:31-8. 1999....
- Temporary transverse colostomy vs loop ileostomy in diversion: a case-matched studyY Sakai
Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Surg 136:338-42. 2001..7% vs 1.6%). CONCLUSIONS: Regarding safety, TC and LI should be considered equivalent options for temporary fecal diversion. We recommend further study comparing the 2 procedures with regard to patient perception and quality of life...
- Dexloxiglumide Rotta Research LabGabor Varga
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest
Curr Opin Investig Drugs 3:621-6. 2002..In August 2000, Merrill Lynch expected that dexloxiglumide would not be launched until 2004 , and in June 2001, predicted a US filing date in 2003 ...
- [An epidemiological study on the risk factors of irritable bowel syndrome in Zhanjiang, Guangdong province]H Ma
Department of Gastrology, PLA422 Hospital, Zhanjiang 524005, China
Zhonghua Liu Xing Bing Xue Za Zhi 22:452-4. 2001..CONCLUSION: Our investigation suggested that the six major risk factors mentioned above played important roles in the progression of IBS in Zhanjiang city...
- Acupuncture treatment for irritable bowel syndrome. A double-blind controlled studyZ Fireman
Department of Gastroenterology, Hillel Yaffe Medical Center, Hadera, Israel
Digestion 64:100-3. 2001..This study aimed at exploring the therapeutic value of acupuncture by comparing the responses of irritable bowel syndrome sufferers to true acupuncture versus sham acupuncture in a controlled double-blind study...
- The gut as a neurological organP Holzer
Department of Experimental and Clinical Pharmacology, University of Graz, Austria
Wien Klin Wochenschr 113:647-60. 2001..The ENS and extrinsic afferents are hence prime targets for the therapeutic management of gut diseases and for the relief of the pain and discomfort associated with these disorders...
- Trimebutine: mechanism of action, effects on gastrointestinal function and clinical resultsM Delvaux
Gastroenterology Unit, CHU Rangueil, Toulouse, France
J Int Med Res 25:225-46. 1997..It is also effective in children presenting with abdominal pain...
- The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patientsE A Mayer
CURE Digestive Diseases Research Center Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90073, USA
Aliment Pharmacol Ther 16:1357-66. 2002....
- Comorbid clinical conditions in chronic fatigue: a co-twin control studyL A Aaron
Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Gen Intern Med 16:24-31. 2001....
- Irritable bowel syndromeS M Turner
Department of Family Medicine, Oklahoma State University College of Osteopathic Medicine, 1111 W 17th Street, Tulsa, OK 74107 1898, USA
Curr Rev Pain 4:54-9. 2000..However, further collaboration between scientists and clinicians from multiple disciplines is strongly encouraged...
- An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndromeM Simren
Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
Gut 48:20-7. 2001..Visceral hypersensitivity is a feature of the irritable bowel syndrome (IBS). Postprandial symptoms are common in these patients. The effects of nutrients on colonic perception in IBS are incompletely understood...
- [Some problems on standardization of clinical study on functional gastro-intestinal diseases in Chinese medicine]Wei An Wang
Zhongguo Zhong Xi Yi Jie He Za Zhi 24:941-3. 2004
- [How extensively should irritable bowel syndrome be investigated? Expensive bowel sounds in the abdomen]M Fliegner-Baia
Medizinische Klinik, Stadtspital Triemli, Zurich, Schweiz
MMW Fortschr Med 144:28-33. 2002..An orienting medical history, clinical examination and exclusion of such alarm symptoms as weight loss, general debility and rectal bleeding, must be followed by a rational choice of further diagnostic measures...
- [Irritable bowel syndrome: pathophysiology and (future) treatment options]A M P De Schryver
Universitair Medisch Centrum, afd Gastro enterologie, Postbus 85 500, 3508 GA Utrecht
Ned Tijdschr Geneeskd 146:12-7. 2002....
- Is irritable bowel syndrome more likely to be persistent in those with relatives who suffer from gastrointestinal symptoms? A population-based study at three time pointsJ S Kalantar
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 17:1389-97. 2003..We tested the hypothesis that subjects with relatives who suffered from abdominal pain or bowel dysfunction would be at an increased risk of more persistent irritable bowel syndrome...
- The use of endoscopy in patients with gastrointestinal motility problemsR Sander
First Medical Department, Municipal Hospital Harlaching, Teaching Hospital of the LM University, Munchen, Germany
J Clin Gastroenterol 33:185-90. 2001..g., GERD). Furthermore, endoscopic interventional procedures offer sufficient treatment of several motility-related disorders (e.g., achalasia, GERD, its associated diseases, secondary constipation)...
- Prevalence of gastrointestinal diseases in two British national birth cohortsA G C Ehlin
Enheten för Klinisk Epidemiologi, Institutionen för medicin vid Karolinska Sjukhuset, Karolinska Institutet, Stockholm, Sweden
Gut 52:1117-21. 2003..Few studies have investigated the prevalence of multiple gastrointestinal diseases in the general British population...
- Functional brain imaging in irritable bowel syndrome with rectal balloon-distention by using fMRIYao Zong Yuan
Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
World J Gastroenterol 9:1356-60. 2003....
- Psychopathology in irritable bowel syndrome: support for a psychophysiological modelMark A Sykes
Department of Psychology, Center for Stress and Anxiety Disorders, University at Albany, State University of New York, 1535 Western Avenue, Albany, New York 12203, USA
J Behav Med 26:361-72. 2003..Anxiety disorders were the most likely disorder to develop before IBS. These results support the theory that psychiatric symptoms, especially anxiety, play a role in the development of IBS...
- Lower gastrointestinal disease in womenR P Smith
Department of Obstetrics and Gynecology, Truman Medical Center, University of Missouri at Kansas City, Kansas City, Missouri, USA
Obstet Gynecol Clin North Am 28:351-61, viii. 2001..A new understanding of the underlying pathophysiology of the most common condition, irritable bowel syndrome, is changing both diagnosis and therapy...
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMICHAEL L CAMILLERI; Fiscal Year: 2010..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
- ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROMEMichael Camilleri; Fiscal Year: 2008..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
- ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBSMichael Camilleri; Fiscal Year: 2007..abstract_text> ..
- Abdominal Symptom Phenotypes: Pathways to New BiomarkersRobert Shulman; Fiscal Year: 2010..New biomarkers (video capsule endoscopy, lymphocyte activation/cytokine diffuse noxious inhibitory control testing) will be used with newly recruited IBS and control subjects. ..
- Integrating CAM: Nursing EmphasisMargaret Heitkemper; Fiscal Year: 2006..abstract_text> ..
- Women's Health Complementary and Alternative TherapiesMargaret Heitkemper; Fiscal Year: 2004..abstract_text> ..
- MULTICENTER TRIAL OF FUNCTIONAL BOWEL DISORDERSDouglas Drossman; Fiscal Year: 2001....
- NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBSLin Chang; Fiscal Year: 2010..abstract_text> ..
- PURINERGIC NEUROGENIC MUCOSAL SECRETIONJACKIE WOOD; Fiscal Year: 2008..unreadable] [unreadable]..
- BRADYKININ IN ENTERIC NEUROIMMUNE COMMUNICATIONJACKIE WOOD; Fiscal Year: 2005..The overall goal of the study is to better understand the role of bradykinin in motility disturbances, diarrhea, abdominal pain and inflammation. ..
- TRIP for postpartum depression (TRIPPD)Barbara Yawn; Fiscal Year: 2009..Equally importantly, it will provide information necessary to translate this evidence into 9eneral primary care practices. ..
- EVALUATION OF CHD IN MEN AND WOMEN PRIOR TO FIRST AMIBarbara Yawn; Fiscal Year: 2002..In addition, we will provide specific information on current gender-related practice patterns. This information can be used to inform future practice recommendations. ..
- Development of the enteric nervous system: Cells & genesMichael Gershon; Fiscal Year: 2006..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
- Treatment of Fear and Pain in Irritable Bowel SyndromeBruce Naliboff; Fiscal Year: 2006..abstract_text> ..
- NK CELL ACTIVITY AND IBS ACROSS THE MENSTRUAL CYCLESandra Motzer; Fiscal Year: 2002..abstract_text> ..
- SIMPLE VERTEBRATE AND INVERTEBRATE SYSTEMSMichael Gershon; Fiscal Year: 2005..Almost all trainees have continued to be productive in biomedical science and some have acquired leadership positions. ..
- Colon Polyp Screening with Colonoscopy in WomenPhilip Schoenfeld; Fiscal Year: 2005..Ultimately, the proposed research studies, didactic coursework, and mentoring hopefully will lead to successful R01 applications. ..
- COMPLEMENTATION ASSAY TO SCREEN FOR KINASE INHIBITORSRICHARD EGLEN; Fiscal Year: 2004..abstract_text> ..
- Alcohol, iNOS upregulation, leaky gut & liver diseaseAli Keshavarzian; Fiscal Year: 2009..Significance: Showing that ALD requires a leaky gut, &that NO &cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test);2) lead to therapies to prevent LD in those drinkers unable to abstain. ..
- Psychosocial Intervention for Children with IBDRona L Levy; Fiscal Year: 2010..Results may lead to innovative interventions for IBD and other chronic childhood medical conditions. ..
- Neurobiol mechanism/acupuncture therapy/alcoholismJiang Hong Ye; Fiscal Year: 2004..This new knowledge will have a major impact on our understanding of how acupuncture works. The application of this knowledge is expected to improve the effectiveness of acupuncture treatment in alcohol addiction. ..
- Complementation Assay for GPCR DesensitizationRICHARD EGLEN; Fiscal Year: 2003..Furthermore, these assays could have a broader role in drug discovery by identifying agonists at the large population of orphan GPCRs since stimulation of all GPCRs causes BARK and B-arrestin translocation. ..
- Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransHashem El Serag; Fiscal Year: 2009..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
- Trafficking of Channels Measured by EFCRICHARD EGLEN; Fiscal Year: 2004..These initial studies will form the foundation of future phase II SBIR studies to develop EFC into a HTS assay for ICC transport for use by bioteclmology and pharmaceutical companies for drug discovery. ..
- ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDERAdil Bharucha; Fiscal Year: 2002..abstract_text> ..
- Ethanol and mesolimbic GABAergic neuronsJiang Hong Ye; Fiscal Year: 2007..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
- Epidemiology and Mechanisms of Fecal IncontinenceAdil Bharucha; Fiscal Year: 2005..abstract_text> ..
- Gene Expression in Barrett's EsophagusHashem El Serag; Fiscal Year: 2006..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
- ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTIONJiang Hong Ye; Fiscal Year: 2003....