Genomes and Genes
Summary: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
Publications293 found, 100 shown here
- The study of infectious intestinal disease in England: socio-economic impactJ A Roberts
Collaborative Centre for Economics of Infectious Disease, Health Services Research Unit, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
Epidemiol Infect 130:1-11. 2003..The estimated cost of IID in England was Pound Sterling743m expressed in 1994/5 prices. The costs of IID are considerable and the duration of the illness was found to be longer than previous reports have suggested...
- A self administered reliable questionnaire to assess lower bowel symptomsBarbara Ann Adelstein
Screening and Test Evaluation Program STEP, School of Public Health, University of Sydney, Australia
BMC Gastroenterol 8:8. 2008..Our aim was to develop a self administered questionnaire for eliciting the presence, nature and severity of lower bowel symptoms potentially related to colorectal cancer, and assess its reliability...
- New perspectives for children with microvillous inclusion disease: early small bowel transplantationFrank M Ruemmele
Combined Program of Liver and Intestinal Transplantation, Hopital Necker Enfants Malades, Paris, France
Transplantation 77:1024-8. 2004..Despite long-term total parenteral nutrition, life expectancy is extremely reduced because of metabolic or septic complications or liver failure...
- Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utilityMaurice M A L Pelsers
Department of Molecular Genetics, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
Clin Biochem 36:529-35. 2003..We have investigated the tissue distribution of I-FABP and L-FABP in segments of the human intestine along the duodenal to colonal axis and the potential of both proteins to serve as plasma marker for the diagnosis of intestinal injury...
- Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumoniaJessica A Dominguez
Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
Shock 36:381-9. 2011..28%, respectively, P < 0.05) and were protected from pneumonia-induced intestinal injury. Thus, EGF may be a potential adjunctive therapy for pneumonia, mediated in part by its effects on the intestine...
- Efficacy of combination therapy of anti-TNF-α antibody infliximab and methotrexate in refractory entero-Behçet's diseaseShigeru Iwata
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahata Nishi, Kitakyushu, 807 8555, Japan
Mod Rheumatol 21:184-91. 2011....
- Quality of life three years after diagnosis of localised prostate cancer: population based cohort studyDavid P Smith
Cancer Council, Kings Cross, New South Wales 1340, Australia
BMJ 339:b4817. 2009..To quantify the risk and severity of negative effects of treatment for localised prostate cancer on long term quality of life...
- Development of consensus statements for the diagnosis and management of intestinal Behçet's disease using a modified Delphi approachKenji Kobayashi
Department of Medicine, Division of General Medicine, Tokai University School of Medicine, Isehara, Japan
J Gastroenterol 42:737-45. 2007..The objective of this study was to develop consensus-based practice guidelines for diagnosis and treatment of intestinal Behçet's disease by using a modified Delphi approach...
- Development and validation of novel diagnostic criteria for intestinal Behçet's disease in Korean patients with ileocolonic ulcersJae Hee Cheon
Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120 752, Korea
Am J Gastroenterol 104:2492-9. 2009..We conducted this study to develop and validate novel diagnostic criteria for intestinal BD...
- Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosisM Bazot
Department of Radiology, Hopital Tenon, Paris, France
Ultrasound Obstet Gynecol 24:180-5. 2004..To determine the accuracy of transvaginal sonography (TVS) for the diagnosis of deep pelvic endometriosis...
- Lymphocytic colitis: a retrospective clinical study of 199 Swedish patientsM Olesen
Department of Medicine, Division of Gastroenterology, Orebro University Hospital, Orebro, Sweden
Gut 53:536-41. 2004..Lymphocytic colitis is characterised by chronic diarrhoea and specific microscopic changes in a macroscopically normal colonic mucosa. We report clinical features and treatment outcome in a large patient cohort...
- Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathyJunru Wang
Department of Surgery, University of Arkansas for Medical Sciences, United States
World J Gastroenterol 13:3047-55. 2007..Endothelial-oriented interventions are appealing strategies to prevent or treat normal tissue toxicity associated with radiation treatment of cancer...
- HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injuryRena Feinman
UMDNJ New Jersey Medical School, Dept of Surgery, Newark, 07103, USA
Am J Physiol Gastrointest Liver Physiol 299:G833-43. 2010..Consequently, these results provide unique information on the initiating events in trauma-hemorrhagic shock-induced ALI and MODS as well as potential therapeutic insights...
- Methods for determining disease burden and calibrating national surveillance data in the United Kingdom: the second study of infectious intestinal disease in the community (IID2 study)Sarah J O'Brien
School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester, M13 9PL, UK
BMC Med Res Methodol 10:39. 2010..We will also outline methods to determine whether or not incidence has declined since the mid-1990s...
- Colonoscopic findings in intestinal BehÃ§et's diseaseC R Lee
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
Inflamm Bowel Dis 7:243-9. 2001....
- Colonisation and shedding of Lawsonia intracellularis in experimentally inoculated rodents and in wild rodents on pig farmsA M Collins
Department of Industry and Investment NSW, Elizabeth Macarthur Agricultural Institute, PMB 4008, Narellan, New South Wales 2567, Australia
Vet Microbiol 150:384-8. 2011..This study demonstrates that rodents may be an important reservoir of L. intracellularis on piggeries, and hence rodent control is important in disease eradication programs on pig farms...
- Video capsule endoscopy of the small bowelRami Eliakim
Department of Gastroenterology, Rambam Healthcare Campus, Rappoport School of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
Curr Opin Gastroenterol 26:129-33. 2010..The capsule is propelled via peristalsis through the gastrointestinal tract and is excreted naturally. We will review all recent work concerning SBCE...
- Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relativesLaura de Magistris
Department Magrassi Lanzara, Gastroenterology, Second University of Naples, Italy
J Pediatr Gastroenterol Nutr 51:418-24. 2010..Faecal calprotectin (FC) was also measured in patients with autism, either with or without gastrointestinal symptoms, and in their first-degree relatives...
- The pathogenic potential of Campylobacter concisus strains associated with chronic intestinal diseasesNadeem O Kaakoush
School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia
PLoS ONE 6:e29045. 2011..its association with intestinal disease, thus, the pathogenic potential of strains isolated from different intestinal diseases was investigated. A method to isolate C...
- Myofibroblasts. II. Intestinal subepithelial myofibroblastsD W Powell
University of Texas Medical Branch at Galveston, Department of Internal Medicine, Galveston, Texas 77555 0567, USA
Am J Physiol 277:C183-201. 1999..More investigation is needed to clarify the functions of these pleiotropic cells...
- Clinical course of intestinal Behcet's disease during the first five yearsYoon Suk Jung
Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul, Korea
Dig Dis Sci 58:496-503. 2013..We aimed to evaluate the clinical course of intestinal BD during the first 5 years after diagnosis, and to identify factors that could predict the 5-year clinical course...
- Purgative bowel cleansing combined with simethicone improves capsule endoscopy imagingWei Wei
Department of Gastroenterology, Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Am J Gastroenterol 103:77-82. 2008..To evaluate the effects of the various methods of small bowel preparation on the quality of visualization of the small bowel and the gastrointestinal transit time of capsule endoscopy (CE)...
- Evidence of host adaptation in Lawsonia intracellularis infectionsFabio A Vannucci
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St, Paul, MN, 55108, USA
Vet Res 43:53. 2012..The objective of this study was to evaluate the susceptibilities of pigs and horses to L. intracellularis infection using either a porcine or an equine isolate...
- Protective role of p70S6K in intestinal ischemia/reperfusion injury in miceKechen Ban
Department of Surgery, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
PLoS ONE 7:e41584. 2012..These novel results demonstrate a key role of p70S6K in protection against I/R injury in the intestine and suggest a potential danger in using mTOR inhibitors in patients at risk for gut hypoperfusion...
- High rates of mortality and morbidity occur in infants with parenteral nutrition-associated cholestasisTheresa C Willis
United States Department of Agriculture Agricultural Research Service, Children s Nutrition Research Center and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
JPEN J Parenter Enteral Nutr 34:32-7. 2010..The authors evaluated a cohort of infants at a large center to determine the outcome of PN-associated cholestasis in infants with some gastrointestinal function...
- Diagnosis of ischemic small bowel disease by measurement of serum intestinal fatty acid-binding protein in patients with acute abdomen: a multicenter, observer-blinded validation studyTatsuo Kanda
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951 8510, Japan
J Gastroenterol 46:492-500. 2011..We aimed to evaluate the clinical usefulness of serum I-FABP measurement for the diagnosis of ischemic small bowel disease...
- Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolutionPedro M G Soares
Centro de Biomedicina, Faculdade de Medicina, Universidade Federal do Ceara, Rodolfo Teofilo, Fortaleza, Brazil
Cancer Chemother Pharmacol 63:91-8. 2008..To evaluate gastrointestinal motility during 5-fluorouracil (5-FU)-induced intestinal mucositis...
- Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classificationCharles Chapron
Service de Chirurgie Gynecologique, Service de Chirurgie Digestive and Service Central d Anatomie et Cytologie Pathologiques, Assistance Publique Hopitaux de Paris AP HP, Paris, France
Hum Reprod 18:157-61. 2003..Deeply infiltrating endometriosis (DIE) is recognized as a specific entity responsible for pain. The distribution of locations and their contribution to surgical management has not been previously studied...
- Radiologic investigations complement and add diagnostic information to capsule endoscopy of small-bowel diseasesDean D T Maglinte
Department of Radiology, Indiana University School of Medicine and Indiana University Hospital, 550 N University Blvd, UH 0279, Indianapolis, IN 46202 5253, USA
AJR Am J Roentgenol 189:306-12. 2007....
- Transvaginal ultrasonography combined with water-contrast in the rectum in the diagnosis of rectovaginal endometriosis infiltrating the bowelMario Valenzano Menada
Department of Obstetrics and Gynaecology, San Martino Hospital, University of Genoa, Genoa, Italy
Fertil Steril 89:699-700. 2008..In 4 of 5 (80.0%) nodules reaching the submucosa, the depth of infiltration was underestimated by RWC-TVS. The RWC-TVS reliably determined the largest diameter of the endometriotic nodules and was well tolerated by the patients...
- Staphylococcus aureus and Clostridium difficile cause distinct pseudomembranous intestinal diseasesM Kent Froberg
University of Minnesota, Duluth, Minnesota, USA
Clin Infect Dis 39:747-50. 2004..difficile infection, as well as confluent, loosely adherent pseudomembranes in the small bowel. Identification of MRSA in the small bowel pseudomembrane by polymerase chain reaction supports S. aureus as an enteric pathogen...
- Anti-Saccharomyces cerevisiae antibody in intestinal Behçet's disease patients: relation to clinical courseChang Hwan Choi
Department of Internal Medicine, Institute of Gastroenterology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
Dis Colon Rectum 49:1849-59. 2006....
- Comparison of intestinal mucosa homogenate and pure culture of the homologous Lawsonia intracellularis isolate in reproducing proliferative enteropathy in swineRoberto M C Guedes
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
Vet Microbiol 93:159-66. 2003..In conclusion, the L. intracellularis isolate PHE/MN1-00 reproduces typical clinical signs and lesions of PE similar to the homologous infection with an intestinal mucosa homogenate...
- Vibrio vulnificus rtxA1 gene recombination generates toxin variants with altered potency during intestinal infectionJayme S Kwak
Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 108:1645-50. 2011..This finding would imply further that in the future on-going genetic variation of the MARTX(Vv) toxins could result in the emergence of novel strains with altered virulence in humans...
- Comparison of capsule endoscopy with enteroclysis in the investigation of small bowel diseaseArumugam Rajesh
Department of Radiology, Indiana University School of Medicine, Indiana University Medical Center, Indianapolis, IN 46202, USA
Abdom Imaging 34:459-66. 2009..To compare results of capsule endoscopy with those of barium enteroclysis or CT enteroclysis...
- Clinical impact of capsule endoscopy compared to push enteroscopy: 1-year follow-up studyJ C Saurin
Dept of Gastroenterology, Centre Hospitalier Lyon Sud, Pierre Benite, France
Endoscopy 37:318-23. 2005..In this study, the clinical outcome was used as the gold standard to determine the sensitivity and specificity of CE and push enteroscopy (PE) in the diagnosis of small-bowel lesions in patients with obscure bleeding...
- Chronological changes in the systemic manifestations of intestinal Behcet's disease and their significance in diagnosisSung Jae Shin
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun Ku, Seoul, Korea
Int J Colorectal Dis 25:1371-6. 2010....
- Influence of age at diagnosis and sex on clinical course and long-term prognosis of intestinal Behcet's diseaseYoon Suk Jung
Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
Inflamm Bowel Dis 18:1064-71. 2012..The aim of this study was to examine the influence of age at diagnosis and sex on the clinical course and long-term prognosis of intestinal Behcet's disease (BD)...
- The role of methane in intestinal diseasesDavide Roccarina
Internal Medicine Department, Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy
Am J Gastroenterol 105:1250-6. 2010..An overview of the present knowledge about the physiology of CH4 metabolism and its role in intestinal diseases is provided in this report.
- Attenuation of virulence of Lawsonia intracellularis after in vitro passages and its effects on the experimental reproduction of porcine proliferative enteropathyFabio A Vannucci
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA
Vet Microbiol 162:265-9. 2013..intracellularis between 20 and 40 cell passages in vitro. This information will be valuable for design of future experimental models and for studying the mechanisms involved in the attenuation of L. intracellularis virulence...
- Diagnostic yield of wireless capsule enteroscopy in comparison with computed tomography enteroclysisW A Voderholzer
Dept of Medicine IV Gastroenterology Hepatology Endocrinology Metabolism, Charite University Hospital, Humboldt University, Berlin, Germany
Endoscopy 35:1009-14. 2003..In a prospective study, the diagnostic yield of wireless enteroscopy was therefore compared with computed tomography (CT) enteroclysis...
- Tri-county comprehensive assessment of risk factors for sporadic reportable bacterial enteric infection in childrenDonna M Denno
Department of Pediatrics and Global Health, University of Washington, Public Health Seattle and King County, Seattle, Washington, USA
J Infect Dis 199:467-76. 2009..The aim of this study was to determine risk factors for childhood sporadic reportable enteric infection (REI) caused by bacteria, specifically Campylobacter, Salmonella, Escherichia coli O157, or Shigella (REI-B)...
- Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure ConsortiumRobert H Squires
Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
J Pediatr 161:723-8.e2. 2012..To characterize the natural history of intestinal failure (IF) among 14 pediatric centers during the intestinal transplantation era...
- Optimal approach for small bowel capsule endoscopy using polyethylene glycol and metoclopramide with the assistance of a real-time viewerKunihiro Hosono
Division of Gastroenterology, Yokohama City University School of Medicine, Yokohama, Japan
Digestion 84:119-25. 2011..Capsule endoscopy is limited by the poor image quality of the distal bowel and incomplete small bowel transit. The aim of this study was to establish an optimal medication protocol for capsule endoscopy performed using a real-time viewer...
- Anti-alpha-enolase antibody as a serologic marker and its correlation with disease severity in intestinal Behçet's diseaseSung Jae Shin
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon dong Seodaemun ku, Seoul, 120 752, Korea
Dig Dis Sci 56:812-8. 2011..But unlike CD and UC, serologic markers for intestinal BD are not well known. Recently, anti-α-enolase antibody (AAEA) has been detected in sera from BD patients...
- Intestinal absorption and histomorphometry of Syrian hamsters (Mesocricetus auratus) experimentally infected with Lawsonia intracellularisFabio Augusto Vannucci
Department of Veterinary Clinic and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
Vet Microbiol 145:286-91. 2010..intracellularis. Therefore, malabsorption should be considered as the main mechanism involved in the physiopathology of the diarrhea in L. intracellularis infected animals...
- Response rates to medical treatments and long-term clinical outcomes of nonsurgical patients with intestinal Behçet diseaseMoon Jae Chung
Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
J Clin Gastroenterol 44:e116-22. 2010..The aims of this study were to evaluate the efficacy of medical treatments and to identify factors to predict clinical outcome of intestinal Behçet disease (BD) during medical treatment...
- Complete small-bowel transit in patients undergoing capsule endoscopy: determining factors and improvement with metoclopramideWarwick Selby
AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, Australia
Gastrointest Endosc 61:80-5. 2005..Passage of the capsule endoscope to the colon occurs in only approximately three quarters of patients. This study assessed factors that might influence the completeness of small-bowel transit, including orally administered metoclopramide...
- Long-term clinical outcomes and factors predictive of relapse after 5-aminosalicylate or sulfasalazine therapy in patients with intestinal Behcet diseaseYoon Suk Jung
Division of Gastroenterology, Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
J Clin Gastroenterol 46:e38-45. 2012..In this study, we investigated long-term clinical outcomes and predictors of clinical relapse in patients with intestinal BD receiving 5-ASA/sulfasalazine maintenance therapy...
- Effects of Saccharomyces boulardii on intestinal mucosaJean Paul Buts
Laboratory of Pediatric Gastroenterology and Nutrition, Unit of Pediatric Research, Universite Catholique de Louvain, Louvain, Belgium
Dig Dis Sci 51:1485-92. 2006..In this review, we will focus on the interactions of the yeast with the host intestinal mucosa...
- Prevalence of life-threatening complications in pediatric patients affected by intestinal failureA Diamanti
Home Artificial Nutrition Center, Bambino Gesu Children Hospital, Rome, Piazza S Onofrio 4, 00165 Rome, Italy
Transplant Proc 39:1632-3. 2007..SBS patients on long-term PN therefore require careful management to identify complications early, and they seem to be the candidates for early referral to small bowel transplantation centers...
- Rescue treatment of infants with intestinal failure and parenteral nutrition-associated cholestasis (PNAC) using a parenteral fish-oil-based lipidHon M Cheung
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Level 6, Clinical Sciences Building, Shatin, N T, Hong Kong
Clin Nutr 28:209-12. 2009..Our findings suggest that fish-oil-based parenteral lipid emulsion may contribute to effective treatment of PNAC in selected patients, which should be further evaluated in randomized controlled trials...
- Nutritional benefits of enteral alanyl-glutamine supplementation on rat small intestinal damage induced by cyclophosphamideJin Satoh
Division of Gastroenterology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, Japan
J Gastroenterol Hepatol 18:719-25. 2003..To further evaluate the benefits of enteral supplementation, peptide and amino acid transporter functions must be considered...
- The histological features of intestinal spirochetosis in a series of 113 patientsNorman J Carr
Graduate School of Medicine, University of Wollongong, New South Wales, Australia
Int J Surg Pathol 18:144-8. 2010..It is concluded that spirochetosis in an unselected general population is unlikely to be of pathological significance. Furthermore, if spirochetosis is observed in an inflamed biopsy, it is most likely to be an incidental finding...
- Failure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failureJason S Soden
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado Denver School of Medicine and The Children s Hospital, 13123 E 16th Ave, Box B290, Aurora, CO 80045, USA
J Pediatr 156:327-31. 2010..Despite biochemical and histologic improvement in cholestasis, both patients had persisting, significant portal fibrosis on liver biopsy...
- Novel lipid-based approaches to pediatric intestinal failure-associated liver diseaseIvan R Diamond
Child Health Evaluative Sciences Program, The Hospital for Sick Children, Toronto, Ontario, Canada
Arch Pediatr Adolesc Med 166:473-8. 2012..Therefore, there is currently insufficient evidence to support the use of these novel therapies as standard of care in children with no or early IFALD with the goal of preventing the progression of liver disease...
- Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositisOrleâncio Gomes R Azevedo
Center for Global Health, School of Medicine, University of Virginia, Carter Harrison Bldg MR 6, 625 Crispell Drive, Charlottesville, VA 22908, USA
BMC Gastroenterol 12:35. 2012..Experiments were also conducted in C57BL6J ApoE knock-out mice to assess the effects of apoE peptide treatment...
- Comparative prevalences of Brachyspira aalborgi and Brachyspira (Serpulina) pilosicoli as etiologic agents of histologically identified intestinal spirochetosis in AustraliaA S Mikosza
Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia
J Clin Microbiol 39:347-50. 2001..This study demonstrates that B. aalborgi is much more commonly involved in histologically identified IS in Australian patients than is B. pilosicoli. This is the first report of amplification of B. pilosicoli DNA from humans with IS...
- Patient and community preferences for outcomes in prostate cancer: implications for clinical policyMurray Krahn
Department of Medicine And Programme in Clinical Epidemiology and Health Care Research, University of Toronto, Ontario, Candada
Med Care 41:153-64. 2003..Utilities can be elicited directly from patients using standard techniques, or indirectly, using questionnaires that incorporate preference weights from community members...
- Intestinal spirochetosis in children: five new cases and a 20-year review of the literatureDavid F Carpentieri
Clinical Laboratory, Phoenix Children s Hospital, Phoenix, AZ 85016, USA
Pediatr Dev Pathol 13:471-5. 2010..Further investigations are needed to determine the correlation between IS and coexisting gastrointestinal diseases and/or immunodeficiencies...
- Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in micePedro M G Soares
Department of Morphology, Federal University of Ceara, Fortaleza, CE, Brazil
Cancer Chemother Pharmacol 68:713-20. 2011..This study evaluated the role of PAF in 5-fluorouracil (5-FU)-induced intestinal mucositis using a pharmacological approach and PAF receptor knockout mice (PAFR(-/-))...
- A new syndrome of tufting enteropathy and choanal atresia, with ophthalmologic, hematologic and hair abnormalitiesLynne M Bird
Rady Children s Hospital San Diego, California 92123, USA
Clin Dysmorphol 16:211-21. 2007..We compare this syndrome with previously reported intractable diarrhea syndromes and speculate on the developmental mechanisms that could account for many of the features demonstrated by this sibship...
- Human intestinal spirochaetosis in Parma: a focus on a selected population during 2002-2005Simona Peruzzi
Department of Pathology and Laboratory Medicine, Section of Microbiology, University of Parma, Parma, Italy
Acta Biomed 78:128-32. 2007..Since poor data were available on the prevalence of this infection, the aim of our study was to describe the occurrence of this infection in our area in the period 2002-2005...
- Endoscopic approach to capsule endoscope retentionAndrew K Roorda
Section of Digestive Diseases, Department of Medicine, West Virginia University School of Medicine, P O Box 9161, Morgantown, WV 26506 9161, USA
Expert Rev Gastroenterol Hepatol 4:713-21. 2010..This article discusses both standard and advanced endoscopic approaches to capsule retention, and presents an algorithmic approach to their utilization...
- Intestinal colonisation, microbiota and future probiotics?Seppo Salminen
Functional Foods Forum, University of Turku, Turku, Finland
Asia Pac J Clin Nutr 15:558-62. 2006..Potential combinations of specific probiotics may prove to be the next step to reduce the risk on intestinal diseases and reconstruct specific microbial deviations.
- Behcet's disease associated with bone marrow failure in Korean patients: clinical characteristics and the association of intestinal ulceration and trisomy 8J K Ahn
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 IIwon Dong, Gangnam Gu, Seoul 135 710, Republic of Korea
Rheumatology (Oxford) 47:1228-30. 2008..The aim of this study was to determine the clinical characteristics of Behcet's disease (BD) associated with bone marrow failure (BMF), classified as conditions such as myelodysplastic syndrome (MDS) or aplastic anaemia (AA), in Korea...
- Quality of life and satisfaction with outcome among prostate-cancer survivorsMartin G Sanda
Departments of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard University, Boston, MA 02215, USA
N Engl J Med 358:1250-61. 2008....
- The geoepidemiology of autoimmune intestinal diseasesIan Logan
Division of Gastroenterology, University of California Davis, USA
Autoimmun Rev 9:A372-8. 2010..Similarly, the prevalence of celiac disease is increasing as the consumption of gluten-containing foods is increasing worldwide...
- A prospective two-center study comparing wireless capsule endoscopy with intraoperative enteroscopy in patients with obscure GI bleedingDirk Hartmann
Department of Gastroenterology, Academic Teaching Hospital, Ludwigshafen, Germany
Gastrointest Endosc 61:826-32. 2005..However, sensitivity and specificity of capsule endoscopy have not been adequately defined. We, therefore, compared capsule endoscopy by using intraoperative enteroscopy as a criterion standard in patients with obscure GI bleeding...
- Human milk glycans protect infants against enteric pathogensDavid S Newburg
Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
Annu Rev Nutr 25:37-58. 2005..These protective glycans may prove useful as a basis for the development of novel prophylactic and therapeutic agents that inhibit diseases caused by mucosal pathogens...
- Feasibility and clinical outcome of laparoscopic colorectal resection for endometriosisEmile Darai
Service de Gynecologie, obstétrique et médecine de la reproduction, Hopital Tenon, Université Saint Antoine Paris VI, Assistance Publique des Hopitaux de Paris, France
Am J Obstet Gynecol 192:394-400. 2005..This study was undertaken to evaluate the feasibility and complications of laparoscopic segmental colorectal resection for endometriosis and its efficacy on gynecologic and digestive symptoms...
- General outbreaks of infectious intestinal disease linked with poultry, England and Wales, 1992-1999A S Kessel
London School of Hygiene and Tropical Medicine
Commun Dis Public Health 4:171-7. 2001..The highlight of this surveillance period was the fall in outbreaks of salmonellosis linked with poultry products, probably due, at least in part, to the vaccination of poultry flocks...
- Human intestinal spirochaetosis: any clinical significance?Walther N K A van Mook
Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
Eur J Gastroenterol Hepatol 16:83-7. 2004..Very infrequently the organism may become invasive. In this article the literature on human intestinal spirochaetosis is reviewed, and key points for daily clinical practice are emphasized...
- Onset and duration of fecal shedding, cell-mediated and humoral immune responses in pigs after challenge with a pathogenic isolate or attenuated vaccine strain of Lawsonia intracellularisRoberto M C Guedes
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 205 Veterinary Science Building, 1971 Commonwealth Avenue, 55108, St Paul, MN, USA
Vet Microbiol 91:135-45. 2003..In summary, both pathogenic isolate challenged and vaccine exposed pigs demonstrated long-term shedding of and immune responses to L. intracellularis...
- Bowel endometriosis: presentation, diagnosis, and treatmentValentino Remorgida
Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Genoa, Italy
Obstet Gynecol Surv 62:461-70. 2007....
- Literature review and recommendations for clinical application of small-bowel capsule endoscopy, based on a panel discussion by international experts. Consensus statements for small-bowel capsule endoscopy, 2006/2007K Mergener
Digestive Health Specialists, Tacoma, Washington, USA
Endoscopy 39:895-909. 2007
- Extragenital endometriosisArathi Veeraswamy
Center for Special Minimally Invasive and Robotic Surgery, Stanford University Medical Center, Palo Alto, California, USA
Clin Obstet Gynecol 53:449-66. 2010..Endoscopy has a pivotal role as both a diagnostic and therapeutic tool...
- Laparoscopic treatment of bowel endometriosisLinda A Lewis
Center for Special Minimally Invasive Surgery, Stanford University Medical Center, Palo Alto, California, USA
Surg Technol Int 16:137-41. 2007..In this chapter, the authors describe five proven techniques for treatment of intestinal endometriosis: shaving, disk excision, anterior rectal wall excision, segmental resection, and appendectomy...
- Surgery for gastrointestinal endometriosis: indications and resultsP Houtmeyers
Departments of Surgery, Ghent University Hospital, Ghent, Belgium
Acta Chir Belg 106:413-6. 2006..The purpose of our study was to report our experience with the diagnosis and treatment of bowel endometriosis...
- Bowel, urinary, and sexual problems among long-term prostate cancer survivors: a population-based studyFloortje Mols
CoRPS Center of Research on Psychology in Somatic diseases, Tilburg University, Tilburg, The Netherlands
Int J Radiat Oncol Biol Phys 73:30-8. 2009..Prostate-specific function was compared with an age-matched normative population without prostate cancer...
- Fertility considerations in laparoscopic treatment of infiltrative bowel endometriosisCatherine Mohr
Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
JSLS 9:16-24. 2005....
- Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopyAymer Postgate
Wolfson Unit for Endoscopy, St Mark s Hospital, London, UK
Gastrointest Endosc 68:1209-14. 2008..New imaging modalities, such as double-balloon enteroscopy (DBE), CT enterography (CTE) or magnetic resonance enterography (MRE) now provide complementary roles to CE for these indications...
- Ovarian endometriosis: a marker for more extensive pelvic and intestinal diseaseD B Redwine
St Charles Medical Center, Bend, Oregon, USA
Fertil Steril 72:310-5. 1999..To describe a computerized pelvic mapping system for pelvic and intestinal endometriosis and preliminary insights gained from it with respect to the effects of ovarian disease...
- Korean experience with double balloon endoscopy: Korean Association for the Study of Intestinal Diseases multi-center studyHwang Choi
Department of Internal Medicine, Our Lady of Mercy Hospital, The Catholic University of Korea, Bupyeong gu, Incheon, Korea
Gastrointest Endosc 66:S22-5. 2007..Double balloon endoscopy (DBE) is a new diagnostic and therapeutic tool for the management of patients with small-bowel disease...
- Endometriosis of the intestinal tract: a study of 44 cases of a disease that may cause diverse challenges in clinical and pathologic evaluationR K Yantiss
Department of Pathology, Harvard Medical School, and the James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Boston 02114, USA
Am J Surg Pathol 25:445-54. 2001..Because the endometriotic foci may be inaccessible to endoscopic biopsy or may not be sampled because of their focality, clinicians and pathologists should be aware of the potential of this condition to mimic other intestinal diseases.
- Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel diseaseDavid W Crook
Department of Nuclear Medicine, University Hospital of Lausanne, Lausanne, Switzerland
Eur J Gastroenterol Hepatol 21:54-65. 2009..The goal of this study was to compare magnetic resonance enterography (MRE) and video capsule endoscopy (VCE) in suspected small bowel disease...
- Intestinal endometriosis: the great masqueraderSuzanne M Skoog
Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiologic Research Program, Enteric Neuroscience Program, Mayo Clinic and Foundation, Charlton 8, 200 First Street SW, Rochester, MN 55905, USA
Curr Gastroenterol Rep 6:405-9. 2004..Identifying intestinal endometriosis can be challenging, but historical points and key clinical features aid in diagnosis...
- Clinical significance of human intestinal spirochetosis--a morphologic approachM Korner
Institute of Pathology, Kantonsspital Luzern, CH 6000 Luzern 16, Switzerland
Infection 31:341-9. 2003..Homosexual and HIV-positive men are more likely to be symptomatic irrespective of invasion. Rare cases of spirochetemia and multiple organ failure have been reported in critically ill patients...
- Endometriosis at several sites, cyclic bowel symptoms, and the likelihood of the appendix being affectedMauricio Simoes Abrao
Department of Obstetrics and Gynecology, University of Sao Paulo Medical School, Sirio Libanes Hospital, Sao Paulo, Brazil
Fertil Steril 94:1099-101. 2010..When these characteristics are present or if patients have more than three sites affected by endometriosis, the surgeon should evaluate the appendix carefully...
- Should the gynecologist perform laparoscopic bowel resection to treat endometriosis? Results over 7 years in 168 patientsRicardo Mendes Alves Pereira
Huntington Reproductive Medicine Centre, Sao Paulo, Brazil
J Minim Invasive Gynecol 16:472-9. 2009..To assess the feasibility and safety of laparoscopic bowel resections for endometriosis performed by gynecologic surgeons...
- Preoperative double-contrast barium enema in patients with suspected intestinal endometriosisStefano Landi
Department of Obstetrics and Gynecology, Ospedale Sacro Cuore, Negrar Verona Italy
J Am Assoc Gynecol Laparosc 11:223-8. 2004..To assess the usefulness of double-contrast barium enema (DCBE) in the diagnosis of endometriotic lesions of the bowel and to define its potential value in preoperative decision making for intestinal surgery...
- Microvillous inclusion disease (microvillous atrophy)Frank M Ruemmele
INSERM EMI 0212, Pediatric Gastroenterology, Hepatology and Nutrition, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
Orphanet J Rare Dis 1:22. 2006..Early small bowel transplantation resulting in intestinal autonomy gives new hope for disease management and outcome...
- Successful pregnancy outcome in tufting enteropathyDonald J S Cameron
J Pediatr Gastroenterol Nutr 36:158. 2003
- Medicinal plants used for intestinal diseases in Mbalmayo region, Central Province, CameroonE Noumi
Laboratoire de Biologie végétale, Ecole Normale Superieure, Université de Yaoundé 1, BP 47, Yaounde, Cameroon
Fitoterapia 72:246-54. 2001Seventy-six plant species from 46 botanical families, traditionally used to treat intestinal diseases in Mbalmayo region are recorded. The local names and the way the plants are used are indicated.
- Campylobacter infection in 682 bulgarian patients with acute enterocolitis, inflammatory bowel disease, and other chronic intestinal diseasesLyudmila Boyanova
Department of Microbiology, Medical University of Sofia, Sofia, Bulgaria
Diagn Microbiol Infect Dis 49:71-4. 2004..7%. The involvement of Campylobacter infection in relapses of chronic intestinal disorders and the susceptibility patterns of the strains strongly emphasize the role of Campylobacter as a cause of infection in this group of patients...
- The significance of bowel permeabilityPeter B Soeters
Department of Surgery, University of Maastricht, The Netherlands
Curr Opin Clin Nutr Metab Care 10:632-8. 2007..In addition, old and new evidence linking inflammation and permeability in abnormal gastrointestinal anatomy and function to liver abnormalities in susceptible patients will be reviewed...
- Isolated small bowel transplantation for tufting enteropathyAnil S Paramesh
The Recanati Miller Transplantation Institute, Sinai School of Medicine, New York, New York 10029, USA
J Pediatr Gastroenterol Nutr 36:138-40. 2003
- Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseasesMaria Armaka
Institute of Immunology, Biomedical Sciences Research Center BSRC Alexander Fleming, Vari 16672, Greece
J Exp Med 205:331-7. 2008..Our results offer a novel mechanistic perspective for TNF function in gut and joint pathologies and indicate early common cellular pathways that may also explain the often observed synovial-gut axis in human disease...
- Cross-sectional and longitudinal comparisons of health-related quality of life between patients with prostate carcinoma and matched controlsRichard M Hoffman
Medicine Service, New Mexico Veterans Affairs Health Care System, Albuquerque, NM 87108, USA
Cancer 101:2011-9. 2004..Prostate carcinoma and treatments affect health-related quality of life (HRQOL). The authors prospectively compared prostate and general HRQOL between prostate carcinoma cases and an age-matched and ethnicity-matched control group...
- Probiotics: progress toward novel therapies for intestinal diseasesFang Yan
Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Monroe Carrel Jr Children s Hospital at Vanderbilt, USA
Curr Opin Gastroenterol 26:95-101. 2010..This review focuses on the most recent advances in probiotic research from genetics to biological consequences regulated by probiotics and probiotic-derived factors...
- Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient miceChris K F Li
Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, UK
J Immunol 173:5171-9. 2004..These studies show that mucosal remodeling can occur in the absence of MMP3, but that MMP3 plays a role in the migration of CD4+ T lymphocytes to the intestinal mucosa...
- Human embryonic stem cell-derived neural crest stem cells and Hirschsprung diseaSean J Morrison; Fiscal Year: 2010..Motility</keyword;keyword>Humans</keyword;keyword>Infant, Newborn</keyword;keyword>Intestinal Diseases/*physiopathology</keyword;keyword>Research Support, Non-U.S...
- Ibis T-6,000 Biosensor SystemCYNTHIA SEARS; Fiscal Year: 2010..of microbes to a wide-range of diseases including respiratory disease in cancer and transplant patients, intestinal diseases such as inflammatory bowel diseases, diarrhea and colon cancer and prostate cancer...
- INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTORRadhakrishna Rao; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: Intestinal diseases such as inflammatory bowel disease and infectious enterocolitis are associated with tissue damage caused by ..
- Structure-Function Studies of the Proton-Gated Urea Channel from H. PyloriHartmut Luecke; Fiscal Year: 2013..This would provide a preventive approach to serious upper gastro-intestinal diseases, particularly stomach cancer, which causes approximately 750,000 deaths annually. Our specific aims are 1...
- Contribution of occludin to intestinal homeostasis and diseaseLe Shen; Fiscal Year: 2013..Disruption of this barrier occurs in inflammatory, infectious, ischemic, and other intestinal diseases and may contribute to the pathogenesis of these diseases...
- Inflammatory Effect of Enteric Bacterial-Mediated Intestinal PermeabilityIAN MICHAEL CARROLL; Fiscal Year: 2013DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) are highly prevalent intestinal diseases in the United States affecting 1.4 million individuals...
- Functional Relevance of CFTR Trafficking in Vivo to Intestinal DiseaseNadia A Ameen; Fiscal Year: 2013..and mechanisms regulating CFTR in the intestine under homeostatic and pathophysiologic conditions and extend insights into CFTR trafficking mechanisms that can be targeted to treat common intestinal diseases such as constipation.
- MicroRNAs in small intestinal epithelial cell proliferation and differentiationANNE MATHEA HUTSON; Fiscal Year: 2012..epithelial cell proliferation and differentiation and identifying their targets could help us find new treatments for intestinal diseases such as intestinal bowel disease and cancer, and for promoting intestinal regrowth and repair.
- Intestinal Microecology, Inflammatory Markers and Necrotizing EnterocolitisJosef Neu; Fiscal Year: 2013..Here we will correlate intestinal microbial patterns and inflammatory marker patterns with non intestinal diseases associated with inflammatory processes in the neonate such hospital acquired sepsis, chronic lung disease ..
- Tight Junction Barriers in the Gastrointestinal TractJames Melvin Anderson; Fiscal Year: 2010..of this project is that loss of selectivity and increased permeability contribute to a number of intestinal diseases, including diarrhea and inflammation...
- Epigenetic regulation of intestinal homeostasisTheresa Alenghat; Fiscal Year: 2013..transition into an independent veterinary scientist that can address questions directed towards molecular advances in diagnostics as well as innovative and targeted therapeutics for intestinal diseases including IBD and cancer.
- ADAM10 in Intestinal Homeostasis and RegenerationPeter J Dempsey; Fiscal Year: 2013DESCRIPTION (provided by applicant): Human intestinal diseases are comprised of a wide variety of pathological states, including chronic illnesses such as inflammatory bowel disease (IBD) and intestinal failure, and thus represent a ..
- DETERMINANTS OF ALPHA DEFENSIN RESISTANCE IN THE INTESTINAL MICROBIOTACHRISTINE TZY YUH LUO; Fiscal Year: 2013..in the intestinal microbiota during homeostasis and a possible link between defensin resistance and disease-inducing potential, may aid in the identification of candidate opportunistic pathogens for IBD and other intestinal diseases.
- Validation of Peripheral Microparticles as Novel Biomarkers of Celiac Disease ActDANIEL ALEXANDER LEFFLER; Fiscal Year: 2013..MPs are found to be responsive and reliable markers of celiac disease activity, MP assessment may be quickly adopted into clinical practice and spur evaluation in other intestinal diseases for which a non-invasive biomarker is needed.
- Genetic analysis of damage-induced intestinal stem cell division in DrosophilaY Tony Ip; Fiscal Year: 2013..of microbes and pathogenic substances is important for developing therapeutic strategies that alleviate intestinal diseases. This proposal focuses on understanding how Drosophila intestinal stem cells (ISCs) mediate repair after ..
- Intestinal Stem Cell Consortium Coordinating CenterJOYCE CAROL NILAND; Fiscal Year: 2013..Of those reported deaths, 9836 were attributable, in part of whole, to conditions of the small intestine. Understanding the biology of the small intestine will aid in the development of therapies to treat intestinal diseases.
- BACTERIAL TOXIN ACTION ON THE DEVELOPING HUMAN GUTW Walker; Fiscal Year: 2000..overall hypothesis for this research proposal is that the pathogenesis of neonatal bacterial inflammatory intestinal diseases and certain secretory diarrheas involving bacterial toxins is principally due to an immature (inappropriate)..
- REGULATION OF AUTOREACTIVE T CELLS IN IL10 KNOCKOUT MICEPeter Ernst; Fiscal Year: 1999..Clarifying the role of these cytokines controlling auto-reactive T cells will define the pathogenesis of colitis and identify therapeutic strategies that can be applied to these intestinal diseases.
- E COLI TRANSLOCATION ACROSS INTESTINAL EPITHELIUMMichelle Pietzak; Fiscal Year: 2003..in premature infants, neonates, immunocompromised hosts, and children with central lines and primary intestinal diseases. Dr. Kim is a prominent researcher in the field of the pathogenesis of E...
- IMMUNE RESPONSE DURING ENTERIC INFLAMMATORY DISEASEMichael Wannemuehler; Fiscal Year: 1993..The cellular mechanisms underlying the causes of intestinal diseases are not fully delineated...
- Using Affymetrix Microflora array to study microflora composition in children witOleg Paliy; Fiscal Year: 2009..This intestinal microflora is a complex community of microorganisms that plays a role in several intestinal diseases such as inflammatory bowel disease, irritable bowel syndrome (IBS), and colon cancer...
- STRUCTURE AND FUNCTION OF CLOSTRIDIUM DIFFICILE TOXINSCharles Faust; Fiscal Year: 1990..Clostridium difficile is also an etiological agent in certain intestinal diseases not related to antimicrobial therapy...
- Mechanisms of epithelial barrier dysfunction mediated by inflammatory cytokinesChristopher Weber; Fiscal Year: 2009..In intestinal diseases such as inflammatory bowel disease, tight junctions, which seal the intercellular space, become leaky and ..
- Intestinal Canal Reconstruction from Video Capsule ImageSTEVEN YI; Fiscal Year: 2005..Video capsule endoscopy is a new technology which revolutionizes the diagnosis of small intestinal diseases. Conventional endoscopy tests, such as gastroscopy and colonoscopy, are effective for the upper or lower ..
- REGULATION OF GENE EXPRESSION IN THE SMALL INTESTINEJeffrey Gordon; Fiscal Year: 2005..determine whether microbes and their products can be used as therapeutic agents to improve nutrition, to promote proper gut development and physiologic functioning, and to prevent or treat various intestinal diseases.
- HUMAN HEPATIC & INTESTINAL UDP GLUCURONOSYLTRANSFERASESAnna Radominska Pandya; Fiscal Year: 2002..intestinal UGT expression on detoxification of drugs and dietary constituents and its impact on hepatic and intestinal diseases. Knowledge of the molecular basis of substrate specificity should have important implications for ..
- MUCOSAL MAST CELLS AND INTESTINAL DISEASESKim Barrett; Fiscal Year: 1992..Inflammatory bowel disease represents a significant, and increasing, cause of morbidity and mortality, especially in developed countries. This study may shed more light n these conditions, and thus suggest new therapeutic modalities...
- COLONIC PROTON PUMP--ROLE IN ELECTROLYTE ABSORPTIONJonathan Kaunitz; Fiscal Year: 1990..It is hoped that detailed knowledge of colon transport proteins may enhance our understanding of intestinal diseases of uncertain etiology such as ulcerative colitis, so that more effective therapies can be devised.
- INTESTINAL CELL MEMBRANES--STRUCTURE AND FUNCTIONMILTON WEISER; Fiscal Year: 1992..and decreased enterocyte polarity are general expressions of enterocyte injury and malfunction seen in many intestinal diseases. Our research should contribute to an understanding of the fundamental cell biology controls in tissue ..
- NUTRITIONAL AND INTESTINAL COMPLICATIONS OF AIDSDonald Kotler; Fiscal Year: 1991..and pathogenetic mechanisms underlying the alterations in body composition that occur as a result of intestinal diseases with nutrient malabsorption or systemic infections with metabolic alterations, and to design effective ..
- GPCR Signaling in Human Colonic Epithelial CellsTerence Chiu; Fiscal Year: 2006..We believe that findings from this proposal will help advance our understanding of fundamental processes in mucosal repair and hopefully allow for design of new therapeutic strategies for human intestinal diseases.
- Crystallography of Multi-Drug Resistant MFS TransportersGeoffrey Chang; Fiscal Year: 2002..the transport of substrate by homologous mammalian transporters, which are involved in diabetes, several intestinal diseases, heart failure, and renal disorders. Our specific aims are: 1...
- Dual-Spectrometer OCT for Noninvasive Imaging of Intestinal CancersJun Ai; Fiscal Year: 2007..widespread use in clinical applications, saving tens of thousands of lives of Americans suffering from intestinal diseases, particularly colorectal cancer...
- MOLECULAR STUDIES OF FOLATE HOMEOSTASISCharles Halsted; Fiscal Year: 2000..The studies are expected to form a basis for future studies on gene regulation of each of the membrane proteins and on a molecular understanding of the pathogenesis of folate deficiency in intestinal diseases.
- Permeability Changes in Small Bowel Allograft RejectionJonathan Fryer; Fiscal Year: 2006....
- Gastric Tube Placement in Young ChildrenMarsha Ellett; Fiscal Year: 2008..Results from this study will increase the safety of using gastric tubes in young children. ..
- GLUTAMINE SYNTHETASE AND INTESTINAL EPITHELIUMJosef Neu; Fiscal Year: 2003..Considering the technical limitations in administering glutamine (degradation in aqueous solutions), these studies will suggest alternatives providing the same benefits in a safer and more practical manner. ..
- Intestinal Barrier Function and Type 1 DiabetesJosef Neu; Fiscal Year: 2005..It will also provide evidence for the efficacy of promising nutritional strategies that can be translated to future trials in human infants at risk for Type 1 diabetes. ..
- PLASMID-MEDIATED VIRULENCE IN SALMONELLADonald Guiney; Fiscal Year: 2008..unreadable] [unreadable]..
- DIET/GROWTH FACTOR MECHANISMS OF GUT ADAPTATIONThomas Ziegler; Fiscal Year: 2004....
- Regulatory B Cells in Mucosal Homeostasis and IBDJonathan Braun; Fiscal Year: 2010..Direct cell transfer experiments will establish whether these cells are required for the protective effect of B cells in these and two biologically divergent colitis systems. ..
- Role of Epithelia In Ischemia Reperfusion InjurySean P Colgan; Fiscal Year: 2010..The overall aim of this proposal is to elucidate the transcriptional signaling events mediating mucosal epithelial responses to hypoxia and inflammation. ..
- ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPYDouglas Miller; Fiscal Year: 2002..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
- BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUNDDouglas Miller; Fiscal Year: 2001..abstract_text> ..
- Role of TLR4 in Acute and Chronic Murine ColitisMaria Abreu; Fiscal Year: 2006..We will use the support from this R21 to generate robust animal models that establish the requirement for TLR4 in the initiation and perpetuation of intestinal inflammation. ..
- Survivor QOL/Spouse Satisfaction after Prostate TherapyMartin Sanda; Fiscal Year: 2007..In so doing, our findings will facilitate appropriately individualizing decision making based on unique characteristics of each prostate cancer patient and his partner. ..
- Carboxyl Ester Lipase Affects Hepatic HDL MetabolismPHILIP HOWLES; Fiscal Year: 2009....
- Abnormal EMPS Expression Affects Pregnancy OutcomeJonathan Braun; Fiscal Year: 2006..These studies, if successful, will reveal a novel and important molecular switch to control pregnancy outcome, and may reveal new pharmacologic targets for contraception design and infertility treatment. ..
- Paracrine Regulation of IGF-I in the Developing IleumPhillip Gordon; Fiscal Year: 2006..abstract_text> ..
- Cytochrome C Oxidase I:A Biomarker for Colon Cancer RiskClaire Payne; Fiscal Year: 2006..Various molecular and cellular techniques will be used in these studies. ..
- PATHOGENS, PROBIOTICS AND THE EPITHELIUM IN COLITISKim Barrett; Fiscal Year: 2007..It may also provide a scientific rationale for continued exploration of probiotics, promising complementary/alternative therapies, in the treatment of inflammatory bowel disease and other intestinal disorders. ..
- Outcomes Research and Training in OncologyJames Talcott; Fiscal Year: 2005..One approach to these issues is to identify differences in outcomes based on the mode of diagnosis (screening vs. investigation of symptoms). ..
- RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINESMyron Levine; Fiscal Year: 2008..abstract_text> ..
- MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATIONLars Eckmann; Fiscal Year: 2008..abstract_text> ..
- BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUNDDouglas Miller; Fiscal Year: 2009..This project will examine bioeffects in cells and tissues and show how to safely use ultrasound contrast agents in diagnostic imaging. ..
- Salmonella-to-Eukaryotic Cell Multi-task Gene DeliveryDonald Guiney; Fiscal Year: 2006..These studies are intended to develop attenuated Salmonella strains for DNA delivery for DNA vaccine approaches, corrective gene therapy, immunotherapy, and the prevention and treatment of certain kinds of cancer. ..
- PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSEAndre J Ouellette; Fiscal Year: 2010..Knowledge of such mechanisms is essential to augment innate defenses and to insure compatibility of new therapeutics with endogenous effectors of host defense. ..
- Toxicokinetics and Toxicodynamics of Nitrite InhalantsHo Leung Fung; Fiscal Year: 2005..We believe that our proposal represents novel approaches toward the understanding of nitrite inhalant toxicity in vivo. ..
- MODULATING TOLERANCE FOR PROSTATE CANCER ANTIGEN VACCINEMartin Sanda; Fiscal Year: 2003..The outcome of these studies will help guide the development of effective immunization strategies targeting hormone-responsive TAA in human prostate and other cancers. ..
- APOE and the Effects of Malnutrition on Cognitive and Intestinal DevelopmentRichard L Guerrant; Fiscal Year: 2010..We will seek to identify potential mechanisms of these effects in the intestine and brain including studies of IGF-1, and will examine the effects of glutamine, zinc, and arginine interventions. ..
- MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASELars Eckmann; Fiscal Year: 2010..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
- Bisphosphonate therapy for HIV-Associated osteopeniaJeannie Huang; Fiscal Year: 2005..Finally, data generated by this pilot study will lay the foundation for future studies of bisphosphonate therapy in HIV-infected persons with bone disease. ..