crohn disease

Summary

Summary: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.

Top Publications

  1. pmc Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    Andre Franke
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    Nat Genet 42:1118-25. 2010
  2. ncbi Inflammatory bowel disease
    Daniel K Podolsky
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 347:417-29. 2002
  3. pmc Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    Harry Sokol
    Unité Ecologie et Physiologie du Système Digestif, Institut National de la Recherche Agronomique U910, Domaine de Vilvert, 78350 Jouy en Josas, France
    Proc Natl Acad Sci U S A 105:16731-6. 2008
  4. pmc Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    Carl A Anderson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 43:246-52. 2011
  5. pmc Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    C Manichanh
    Unité d Ecologie et de Physiologie du Système Digestif, INRA UEPSD, 78350 Jouy en Josas, France
    Gut 55:205-11. 2006
  6. ncbi Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
    Natalie A Molodecky
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 142:46-54.e42; quiz e30. 2012
  7. pmc Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Jeffrey C Barrett
    Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 40:955-62. 2008
  8. pmc Increased expression of interleukin 17 in inflammatory bowel disease
    S Fujino
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Gut 52:65-70. 2003
  9. ncbi Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    S Brand
    Department of Medicine II Grosshadern, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    Gut 58:1152-67. 2009
  10. pmc Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    Warren Strober
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 140:1756-67. 2011

Detail Information

Publications304 found, 100 shown here

  1. pmc Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    Andre Franke
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    Nat Genet 42:1118-25. 2010
    ..Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease...
  2. ncbi Inflammatory bowel disease
    Daniel K Podolsky
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 347:417-29. 2002
  3. pmc Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    Harry Sokol
    Unité Ecologie et Physiologie du Système Digestif, Institut National de la Recherche Agronomique U910, Domaine de Vilvert, 78350 Jouy en Josas, France
    Proc Natl Acad Sci U S A 105:16731-6. 2008
    ..and biodiversity of intestinal bacteria within the dominant phylum Firmicutes has been observed repeatedly in Crohn disease (CD) patients...
  4. pmc Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    Carl A Anderson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 43:246-52. 2011
    ..The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis...
  5. pmc Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    C Manichanh
    Unité d Ecologie et de Physiologie du Système Digestif, INRA UEPSD, 78350 Jouy en Josas, France
    Gut 55:205-11. 2006
    ..However, investigation of such a complex ecosystem is difficult, even with culture independent molecular approaches...
  6. ncbi Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
    Natalie A Molodecky
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 142:46-54.e42; quiz e30. 2012
    ..We conducted a systematic review to determine changes in the worldwide incidence and prevalence of ulcerative colitis (UC) and Crohn's disease (CD) in different regions and with time...
  7. pmc Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Jeffrey C Barrett
    Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 40:955-62. 2008
    ..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...
  8. pmc Increased expression of interleukin 17 in inflammatory bowel disease
    S Fujino
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Gut 52:65-70. 2003
    ..Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory activities. In this study we evaluated changes in IL-17 expression in the inflamed mucosa and in the serum of patients with inflammatory bowel disease (IBD)...
  9. ncbi Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    S Brand
    Department of Medicine II Grosshadern, Ludwig Maximilians University Munich, D 81377 Munich, Germany
    Gut 58:1152-67. 2009
    ..However, the complex relationship between Th1 and Th17 cells has not been completely analysed. This will be of great importance to delineate the specific contributions of these cells to Crohn's disease and other autoimmune diseases...
  10. pmc Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    Warren Strober
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 140:1756-67. 2011
    ..In this review, we will explore this cytokine landscape with the view of providing an understanding of how recent and future anticytokine therapies actually function...
  11. ncbi New IBD genetics: common pathways with other diseases
    C W Lees
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, UK
    Gut 60:1739-53. 2011
    ..This arena will move forwards very quickly in the next few years. Ultimately, we anticipate that these genetic insights will transform the landscape of common complex diseases such as IBD...
  12. pmc Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    Luke Jostins
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK
    Nature 491:119-24. 2012
    ..Gene co-expression network analysis emphasizes this relationship, with pathways shared between host responses to mycobacteria and those predisposing to IBD...
  13. pmc Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
    Steven A McCarroll
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nat Genet 40:1107-12. 2008
    ..These results suggest that the CD association at IRGM arises from an alteration in IRGM regulation that affects the efficacy of autophagy and identify a common deletion polymorphism as a likely causal variant...
  14. pmc Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder
    Peter Holmans
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Heath Park, CF23 6BQ Cardiff, UK
    Am J Hum Genet 85:13-24. 2009
    ..The method was applied to the Wellcome Trust Case-Control Consortium Crohn disease (CD) data set...
  15. pmc The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications
    J Satsangi
    Gstrointestinal Unit, Western General Hospital, University of Edinburg, UK
    Gut 55:749-53. 2006
    ..Here we highlight the key issues that have emerged from discussions of the Montreal Working Party and the relevance to clinical practice and research activities...
  16. pmc XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    Arthur Kaser
    Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Cell 134:743-56. 2008
    ..Hence, intestinal inflammation can originate solely from XBP1 abnormalities in IECs, thus linking cell-specific ER stress to the induction of organ-specific inflammation...
  17. ncbi Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    J P Hugot
    Fondation Jean Dausset CEPH, 27 rue J Dodu 75010 Paris, France
    Nature 411:599-603. 2001
    ....
  18. ncbi Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
    Marie Joossens
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 60:631-7. 2011
    ..Whether dysbiosis is present in relatives of patients CD was also examined...
  19. ncbi A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    Y Ogura
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 411:603-6. 2001
    ..These results implicate NOD2 in susceptibility to Crohn's disease, and suggest a link between an innate immune response to bacterial components and development of disease...
  20. pmc Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis
    James C Lee
    Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    J Clin Invest 121:4170-9. 2011
    b>Crohn disease (CD) and ulcerative colitis (UC) are increasingly common, chronic forms of inflammatory bowel disease. The behavior of these diseases varies unpredictably among patients...
  21. pmc Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis
    Uri Gophna
    Department of Molecular Microbiology and Biotechnology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Clin Microbiol 44:4136-41. 2006
    ..Imbalance in flora in Crohn's disease is probably not sufficient to cause inflammation, since microbiotas from inflamed and noninflamed tissues were of similar compositions within the same individual...
  22. pmc Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
    PLoS Genet 5:e1000534. 2009
    ..An online version of this method is available for public use (http://www.broad.mit.edu/mpg/grail/)...
  23. ncbi Low counts of Faecalibacterium prausnitzii in colitis microbiota
    H Sokol
    UEPSD, INRA, Jouy en Josas, France
    Inflamm Bowel Dis 15:1183-9. 2009
    ..The aim was to compare the fecal microbiota composition of patients with colitis to that of healthy subjects (HS)...
  24. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
    ..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor...
  25. ncbi A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    Ben P Willing
    Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Gastroenterology 139:1844-1854.e1. 2010
    ..Interindividual variation and an inability to detect less abundant bacteria have made it difficult to correlate specific bacteria with disease...
  26. pmc CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
    Suzanne Lesage
    Fondation Jean Dausset CEPH, 27 rue Juliette Dodu, 75010 Paris, France
    Am J Hum Genet 70:845-57. 2002
    ..Mutations in CARD15 have recently been found in patients with Crohn disease (CD), a chronic inflammatory condition of the digestive tract...
  27. ncbi The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases
    Benoit Chassaing
    Clermont Universite, Universite d Auvergne, Jeune Equipe JE 2526, Clermont Ferrand, France
    Gastroenterology 140:1720-28. 2011
    ....
  28. ncbi High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
    Arlette Darfeuille-Michaud
    Pathogenie Bacterienne Intestinale, Laboratoire de Bacteriologie, Universite d Auvergne, Clermont Ferrand, France
    Gastroenterology 127:412-21. 2004
    ..This study was performed to assess the prevalence of AIEC associated with intestinal mucosa of patients with CD, ulcerative colitis (UC), and of controls...
  29. pmc Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype
    Philipp Rausch
    Institute for Experimental Medicine, Christian Albrechts University of Kiel, D 24105 Kiel, Germany
    Proc Natl Acad Sci U S A 108:19030-5. 2011
    ..as "nonsecretors" and display an array of differences in susceptibility to infection and disease, including Crohn disease. To determine whether variation in resident microbial communities with respect to FUT2 genotype is a potential ..
  30. pmc High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease
    Alan W Walker
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Microbiol 11:7. 2011
    ..We therefore specifically sought to compare the mucosa-associated microbiota from both inflamed and non-inflamed sites of the colon in CD and UC patients to that from non-IBD controls and to detect disease-specific profiles...
  31. pmc A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    Ken Cadwell
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 456:259-63. 2008
    ..Thus, ATG16L1, and probably the process of autophagy, have a role within the intestinal epithelium of mice and Crohn's disease patients by selective effects on the cell biology and specialized regulatory properties of Paneth cells...
  32. ncbi Infliximab, azathioprine, or combination therapy for Crohn's disease
    Jean Frederic Colombel
    Hôpital Claude Huriez and Centre d Investigation Clinique, Centre Hospitalier Universitaire de Lille, Universite Lille Nord de France, Lille, France
    N Engl J Med 362:1383-95. 2010
    ..The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown...
  33. ncbi A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
    Patrick Brest
    Inserm ERI 21, EA4319, Faculty of Medicine, Nice, France
    Nat Genet 43:242-5. 2011
    ....
  34. pmc Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, 10098 Berlin, Germany
    J Clin Microbiol 43:3380-9. 2005
    ..A Bacteroides fragilis biofilm is the main feature of IBD. This was not previously recognized due to a lack of appropriate tissue fixation. Both 5-ASA and antibiotics suppress but do not eliminate the adherent biofilm...
  35. ncbi Inflammatory bowel disease: clinical aspects and established and evolving therapies
    Daniel C Baumgart
    Department of Medicine, Division of Gastroenterology and Hepatology, Charité Medical Centre, Virchow Hospital, Medical School of the Humboldt University of Berlin, 13344 Berlin, Germany
    Lancet 369:1641-57. 2007
    ..Finally, we summarise the practical aspects of standard therapies including dosing, precautions, and side-effects...
  36. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    ..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
  37. ncbi Recent insights into the genetics of inflammatory bowel disease
    Judy H Cho
    Department of Medicine and Genetics, Yale University, New Haven, Connecticut, USA
    Gastroenterology 140:1704-12. 2011
    ..Future genetic studies will be directed toward identifying uncommon variations with potentially greater statistical effects, defining population differences, and more completely accounting for familial transmission of disease...
  38. pmc Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
    Andrew M Smith
    Department of Medicine, University College London, London WC1E 6BT, England, UK
    J Exp Med 206:1883-97. 2009
    ..Together, our findings suggest that in CD macrophages, an abnormal proportion of cytokines are routed to lysosomes and degraded rather than being released through the normal secretory pathway...
  39. ncbi NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    Rachel Cooney
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Headington, Oxford, UK
    Nat Med 16:90-7. 2010
    ....
  40. ncbi Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005: a KASID study
    Suk Kyun Yang
    Department of Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
    Inflamm Bowel Dis 14:542-9. 2008
    ..Crohn's disease (CD) and ulcerative colitis (UC) are considered rare diseases in developing countries. We have evaluated the incidence and prevalence of CD and UC over time in a district of Seoul, Korea...
  41. ncbi Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris Cedex 15, France
    J Biol Chem 278:8869-72. 2003
    ..Additionally, the characterization of Nod2 as the first pathogen-recognition molecule that detects MDP will help to unravel the well known biological activities of this immunomodulatory compound...
  42. pmc Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    Miles Parkes
    Inflammatory Bowel Disease Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Genet 39:830-2. 2007
    ..We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13...
  43. pmc Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, 24105 Kiel, Germany
    Am J Hum Genet 90:636-47. 2012
    Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically, and therapeutically connected, but little is known about their shared genetic causes...
  44. ncbi Clinical features and long-term prognosis of Crohn's disease in Korea
    Byong Duk Ye
    Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Scand J Gastroenterol 45:1178-85. 2010
    ..However, the clinical features and course of CD in Asian patients remain unclear. Therefore, we investigated the clinical features and long-term prognosis of CD in a Korean population...
  45. ncbi Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease
    Ben Willing
    Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Inflamm Bowel Dis 15:653-60. 2009
    ..Large interindividual variation in the composition of the intestinal microbiota between unrelated individuals has made it challenging to identify specific aspects of dysbiosis that lead to Crohn's disease (CD)...
  46. pmc Using biological networks to search for interacting loci in genome-wide association studies
    Mathieu Emily
    Bioinformatics Research Center, University of Aarhus, C F Møllers Alle, Aarhus C, Denmark
    Eur J Hum Genet 17:1231-40. 2009
    ....
  47. pmc Nod2 is required for the regulation of commensal microbiota in the intestine
    Tanja Petnicki-Ocwieja
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:15813-8. 2009
    ..Therefore, Nod2 and intestinal commensal bacterial flora maintain a balance by regulating each other through a feedback mechanism. Dysfunction of Nod2 results in a break-down of this homeostasis...
  48. ncbi Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis
    Feng Wu
    Department of Medicine Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Inflamm Bowel Dis 13:807-21. 2007
    ..Ulcerative colitis (UC) and Crohn's disease (CD) are inflammatory bowel diseases (IBD) with variable, overlapping clinical features and complex pathophysiologies...
  49. pmc Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
    Alexandra Chloe Villani
    Division of Gastroenterology, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    Nat Genet 41:71-6. 2009
    ..Mutations in NLRP3 are known to be responsible for three rare autoinflammatory disorders. These results suggest that the NLRP3 region is also implicated in the susceptibility of more common inflammatory diseases such as Crohn's disease...
  50. ncbi Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer
    Helen M Martin
    Department of Medicine, Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 127:80-93. 2004
    ..This study aimed to quantify and characterize mucosa-associated and intramucosal bacteria, particularly Escherichia coli, in these conditions...
  51. ncbi Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark
    Tine Jess
    Department of Medical Gastroenterology, Herlev University Hospital, Copenhagen Denmark
    Inflamm Bowel Dis 13:481-9. 2007
    ..To answer this question, 3 consecutive population-based IBD cohorts from Copenhagen, Denmark (1962-2005), were assessed and evaluated...
  52. pmc Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
    S J Ott
    Department of General Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Gut 53:685-93. 2004
    ..As most of the colonic bacteria cannot be identified by culture techniques, genomic technology can be used for analysis of the composition of the microflora...
  53. ncbi Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
    Stephen B Hanauer
    Department of Gastroenterology and Nutrition, University of Chicago Medical Center, Chicago, IL 60637, USA
    Lancet 359:1541-9. 2002
    ..We did a randomised controlled trial to assess the benefit of maintenance infliximab therapy in patients with active Crohn's disease who respond to a single infusion of infliximab...
  54. ncbi Microbial host interactions in IBD: implications for pathogenesis and therapy
    R Balfour Sartor
    Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, CB 7032, Room 7309, Medical Biomolecular Research Building, Chapel Hill, NC 27599, USA
    Curr Gastroenterol Rep 9:497-507. 2007
    ....
  55. pmc NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    J Wehkamp
    Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany
    Gut 53:1658-64. 2004
    ..Paneth cells also express NOD2. To address the hypothesis that the function of NOD2 may affect expression of Paneth cell defensins, we compared their expression levels with respect to NOD2 mutations in Crohn's disease...
  56. ncbi The incidence of fracture among patients with inflammatory bowel disease. A population-based cohort study
    C N Bernstein
    Section of Gastroenterology, University of Manitoba, 804F 715 McDermot Avenue, John Buhler Research Centre, Winnipeg, Manitoba R3E 3P4, Canada
    Ann Intern Med 133:795-9. 2000
    ..The clinical significance of the high prevalence of osteopenia in inflammatory bowel disease is unclear...
  57. pmc European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis
    E F Stange
    John Radcliffe Hospital, Oxford OX3 9DU, UK
    Gut 55:i1-15. 2006
  58. ncbi IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 290:G827-38. 2006
    ..IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and IEC migration...
  59. ncbi Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum
    Martin Baumgart
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    ISME J 1:403-18. 2007
    ..coli is involved in the etiopathogenesis to Crohn's disease involving the ileum...
  60. ncbi Diagnostics of inflammatory bowel disease
    Susanna Nikolaus
    Department of General Internal Medicine, Christian Albrechts University, Kiel, Germany
    Gastroenterology 133:1670-89. 2007
    ..It can be expected that future diagnostic algorithms will include molecular parameters to detect early disease or guide therapies by predicting the individual course of disease...
  61. pmc Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Hum Genet 84:399-405. 2009
    ..data from the Wellcome Trust Case Control Consortium (WTCCC) and uncovered significant association between Crohn Disease (CD) and the IL12/IL23 pathway, harboring 20 genes (p = 8 x 10(-5))...
  62. ncbi Body mass index and the risk for Crohn's disease and ulcerative colitis: data from a European Prospective Cohort Study (The IBD in EPIC Study)
    Simon S M Chan
    Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, UK
    Am J Gastroenterol 108:575-82. 2013
    ..Our aim was to perform the first prospective cohort study investigating if there is an association between obesity and the development of incident IBD...
  63. pmc Guidelines for the management of inflammatory bowel disease in adults
    M J Carter
    Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Sheffield, UK
    Gut 53:V1-16. 2004
  64. pmc Adalimumab safety and mortality rates from global clinical trials of six immune-mediated inflammatory diseases
    G R Burmester
    Charite University Medicine Berlin, Free University and Humboldt University of Berlin, 10117 Berlin, Germany
    Ann Rheum Dis 68:1863-9. 2009
    ..To assess the safety of adalimumab in rheumatoid arthritis (RA) over time and across five other immune-mediated inflammatory diseases and to compare adalimumab malignancy and mortality rates with data on the general population...
  65. ncbi Defective innate immunity in inflammatory bowel disease: a Crohn's disease exclusivity?
    Daniel J B Marks
    Centre for Molecular Medicine, University College London, London, UK
    Curr Opin Gastroenterol 27:328-34. 2011
    ..This review summarizes the recent developments in support of the immunodeficiency model of Crohn's disease...
  66. ncbi Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease
    A Darfeuille-Michaud
    Laboratoire de Bacteriologie, Faculte de Pharmacie, Clermont Ferrand Cedex, France
    Gastroenterology 115:1405-13. 1998
    ..This study was designed to look for the presence of virulent Escherichia coli strains associated with the ileal mucosa of patients with Crohn's disease...
  67. pmc Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    Ivan J Fuss
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland 20892, USA
    J Clin Invest 113:1490-7. 2004
    While Crohn disease (CD) has been clearly identified as a Th1 inflammation, the immunopathogenesis of its counterpart inflammatory bowel disease, ulcerative colitis (UC), remains enigmatic...
  68. pmc Evaluation of 22 genetic variants with Crohn's disease risk in the Ashkenazi Jewish population: a case-control study
    Inga Peter
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029 USA
    BMC Med Genet 12:63. 2011
    ..We evaluated a set of well-established CD-susceptibility variants to determine if they can explain the increased CD risk in the AJ population...
  69. ncbi Highlighting new phylogenetic specificities of Crohn's disease microbiota
    S Mondot
    UMR1319 MICALIS, INRA, Domaine de Vilvert, 78350 Jouy en Josas, France
    Inflamm Bowel Dis 17:185-92. 2011
    ..Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD)...
  70. ncbi A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease
    William J Sandborn
    The Clinical Trials Task Force of the International Organization of Inflammatory Bowel Disease
    Gastroenterology 122:512-30. 2002
  71. ncbi Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease
    Keiko Yamazaki
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Japan
    Hum Mol Genet 14:3499-506. 2005
    ..Our results suggest that the genetic variations in the TNFSF15 gene contribute to the susceptibility to IBD in the Japanese and European populations...
  72. pmc Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease
    M P Conte
    Paediatric Gastroenterology Unit, University of Rome La Sapienza, Viale Regina Elena 324, Rome 00161, Italy
    Gut 55:1760-7. 2006
    ..No paediatric reports are available on intestinal endogenous microflora in IBD...
  73. ncbi Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    J Keane
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, MA 02118, USA
    N Engl J Med 345:1098-104. 2001
    ..There is no direct evidence of a protective role of TNF-alpha in patients with tuberculosis...
  74. pmc Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
    B von Lampe
    Medizinische Klinik I Gastroenterologie und Infektiologie, Klinikum Benjamin Franklin, FU Berlin, Hindenburgdamm 30, 12200 Berlin, FRG
    Gut 47:63-73. 2000
    ..The current study was therefore designed to determine gene expression patterns of MMPs and their tissue inhibitors (TIMPs) in single endoscopic biopsies of patients with inflammatory bowel disease (IBD)...
  75. ncbi Cancer risk in patients with inflammatory bowel disease: a population-based study
    C N Bernstein
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 3P4
    Cancer 91:854-62. 2001
    ....
  76. pmc IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
    Alessandra Geremia
    Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 9DU, England, UK
    J Exp Med 208:1127-33. 2011
    ..ILCs may contribute to intestinal inflammation through cytokine production, lymphocyte recruitment, and organization of the inflammatory tissue and may represent a novel tissue-specific target for subtypes of IBD...
  77. pmc A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease
    Eleonora A M Festen
    Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    PLoS Genet 7:e1001283. 2011
    ..The combined analysis of the two datasets provided the power, lacking in the individual GWAS for single diseases, to detect shared loci with a relatively small effect...
  78. ncbi NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Room 11N238, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Immunol 5:800-8. 2004
    ..by which mutations in CARD15, which encodes nucleotide-binding oligomerization domain 2 (NOD2), cause Crohn disease is poorly understood...
  79. pmc Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease
    Natalie J Prescott
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Hum Mol Genet 19:1828-39. 2010
    ....
  80. pmc Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    S Zeissig
    Department of Gastroenterology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Gut 56:61-72. 2007
    ..Epithelial barrier function is impaired in Crohn's disease...
  81. ncbi Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease
    D Roggenbuck
    Institute of Immunology, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Gut 58:1620-8. 2009
    ..Autoimmune mechanisms are thought to play a role in the development of Crohn's disease, but the target antigens and the underlying pathways have not been sufficiently identified...
  82. ncbi Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940-2000
    Conor G Loftus
    Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Inflamm Bowel Dis 13:254-61. 2007
    ..We sought to update the incidence and prevalence of these conditions in our region through 2000...
  83. ncbi Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease
    Helga P Török
    Department of Internal Medicine II, Campus Grosshadern, University of Munich, Munich, Germany
    Am J Gastroenterol 104:1723-33. 2009
    ....
  84. pmc Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis
    Nobuhiko Kamada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Clin Invest 118:2269-80. 2008
    ..In patients with Crohn disease (CD), the number of these CD14+ macrophages were significantly increased compared with normal control subjects...
  85. ncbi A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    Richard H Duerr
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Science 314:1461-3. 2006
    ..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease...
  86. ncbi Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis
    Michael Economou
    Department of Medicine, 1st Division of Internal Medicine and Hepato Gastroenterology Unit, University Hospital, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Am J Gastroenterol 99:2393-404. 2004
    ..We assessed the impact of NOD2 variants on the CD risk across diverse populations and examined possible associations with disease phenotype...
  87. ncbi Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies
    Dimitrios P Bogdanos
    Institute of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, King s College London School of Medicine at King s College Hospital, London, UK
    Autoimmun Rev 11:143-8. 2011
    ..Hints towards a better understanding of the immunogenicity of GP2 are also provided...
  88. ncbi Predictors of Crohn's disease
    Laurent Beaugerie
    Department of Gastroenterology, Saint Antoine Hospital, and Pierre et Marie Curie University, Paris, France
    Gastroenterology 130:650-6. 2006
    ..Early intensive therapy in Crohn's disease should be considered only in patients with disabling disease. The aim of our study was to identify at diagnosis factors predictive of a subsequent 5-year disabling course...
  89. pmc Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset
    Jurgen Glas
    Department of Medicine II Grosshadern, University of Munich, Munich, Germany
    PLoS ONE 5:e10373. 2010
    ..We therefore investigated the influence of STAT4 variants on the susceptibility and phenotype of inflammatory bowel diseases (IBD) in a large patient and control cohort...
  90. ncbi Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohn's disease
    Si Ming Man
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
    Inflamm Bowel Dis 16:1008-16. 2010
    ..To further investigate this issue we determined the prevalence of these organisms in pediatric patients newly diagnosed with CD...
  91. pmc ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis
    Craig R Homer
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Gastroenterology 139:1630-41, 1641.e1-2. 2010
    ..We examined the functional interaction between the CD risk genes ATG16L1 and NOD2 to identify an autophagy-dependent pathway that is altered by disease-associated variants...
  92. ncbi Crohn disease of the small bowel: comparison of CT enterography, MR enterography, and small-bowel follow-through as diagnostic techniques
    Seung Soo Lee
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap2 Dong, Songpa Gu, Seoul 138 040, Korea
    Radiology 251:751-61. 2009
    ..of computed tomographic (CT) and magnetic resonance (MR) enterography and small-bowel follow-through (SBFT) examination for detection of active small-bowel inflammation and extraenteric complications in patients with Crohn disease (CD).
  93. pmc Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling
    Oliver von Kampen
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel D 24105, Germany
    J Biol Chem 285:19921-6. 2010
    ..Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells...
  94. ncbi Impact of depressive mood on relapse in patients with inflammatory bowel disease: a prospective 18-month follow-up study
    Christian Mittermaier
    Department of Medicine IV, Division of Gastroenterology and Hepatology, University Hospital of Vienna, Vienna, Austria
    Psychosom Med 66:79-84. 2004
    ..We examined the influence of depressive mood and associated anxiety on the course of IBD over a period of 18 months in a cohort of patients after an episode of active disease...
  95. pmc Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM
    Frederic A Carvalho
    université Clermont 1, Pathogenie Bacterienne Intestinale, JE2526, Unité Sous Contrat Institut National de la Recherche Agronomique 2018, Clermont Ferrand F 63001, France
    J Exp Med 206:2179-89. 2009
    ..Thus, targeting AIEC adhesion to gut mucosa represents a new strategy for clinicians to prevent and/or to treat ileal CD...
  96. pmc High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
    Roman Kotlowski
    Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada
    Gut 56:669-75. 2007
    ..One way of determining which bacteria might be likely candidates is to use culture-independent methods to identify microorganisms that are present in diseased tissues but not in controls...
  97. pmc Gene, region and pathway level analyses in whole-genome studies
    Omar De la Cruz
    Department of Statistics, The University of Chicago, Chicago, Illinois 60637, USA
    Genet Epidemiol 34:222-31. 2010
    ..The power of the approach is investigated in simulated and real datasets. Novel Crohn's disease associations are found using the WTCCC data...
  98. ncbi Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    Frank Heller
    Department of Gastroenterology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Gastroenterology 129:550-64. 2005
    ..Ulcerative colitis (UC) is characterized by a Th2 immune response with inflammation and epithelial barrier dysfunction. So far, Th2 cytokines have not been shown to directly influence epithelial barrier function...
  99. pmc A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
    Eiichiro Noguchi
    Department of Surgery II, Tokyo Women s Medical University, Tokyo, Japan
    Nat Immunol 10:471-9. 2009
    ..We confirmed impairment in phosphorylation of hnRNP-A1 and binding of hnRNP-A1 to the IL10 locus in peripheral blood mononuclear cells from patients with Crohn's disease who bear the 3020insC mutation and have lower production of IL-10...
  100. ncbi Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry
    Melvin B Heyman
    UCSF Children s Hospital, University of California, San Francisco, CA 94143, USA
    J Pediatr 146:35-40. 2005
    ..To determine the characteristics of inflammatory bowel disease (IBD) in young patients...
  101. ncbi Invasive Escherichia coli are a feature of Crohn's disease
    Maiko Sasaki
    Internal Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Lab Invest 87:1042-54. 2007
    ..coli are more prevalent in CD, are highly invasive, and do not encode for known effector proteins. E. coli strains from IBD patients regulate cytokine expression and epithelial barrier function, two pathological features of IBD...

Research Grants63

  1. Genetic Variations and Development of Vesicoureteral Reflux and Sequelae
    DAVID SULLIVAN HAINS; Fiscal Year: 2010
    ..Also, we will investigate potential genetic causes of vesicoureteral reflux. ..
  2. Genetic &immunologic etiology of chronic recurrent multifocal osteomyelitis-CRMO
    Polly J Ferguson; Fiscal Year: 2013
    ..CRMO is often accompanied by psoriasis or inflammatory bowel disease (Crohn disease) suggesting a shared pathogenesis. Gene defects have been found in a subset of individuals with CRMO...
  3. The Human Microbiome in Pediatric Abdominal Pain and Intestinal Inflammation
    James Versalovic; Fiscal Year: 2012
    ..of healthy children and children with irritable bowel syndrome, constipation, and inflammatory bowel disease (Crohn disease), multiple strategies will be deployed to navigate and understand the nature of the intestinal microbiome in ..
  4. Bone Health in Pediatric Crohn Disease: A Low Magnitude Mechanical Stimulus Trial
    MARY BETH LEONARD; Fiscal Year: 2010
    ..Children with Crohn disease (CD) have numerous risk factors for impaired bone accrual, including poor growth, delayed puberty, ..
  5. Polypeptide Conformation and Interaction with Hsp70
    Silvia Cavagnero; Fiscal Year: 2009
    ..These include cystic fibrosis, inflammatory heart disease, Crohn disease, P53-related cancers, and several neurodegenerative disorders such as Huntington's and Alzheimer's ..
  6. FIBROSIS IN CROHNS DISEASE--ROLE OF IGF I
    ELLEN ZIMMERMANN; Fiscal Year: 1999
    ..We will determine the changes in intestinal inflammation and fibrosis resulting from modulation of IGF-I to lend insight into the in vivo roles of IGF-I in mediating intestinal fibrosis. ..
  7. Rare disease susceptibility alleles in children with Crohn disease
    Stephen L Guthery; Fiscal Year: 2013
    ..overall goal of this proposed project is to identify rare genetic variants contributing to childhood onset- Crohn disease. Crohn disease is a chronic inflammatory disorder of the gastrointestinal tract of unclear etiology and no ..
  8. INTESTINAL STRICTURE FORMATION IN CROHNS DISEASE
    Martin Graham; Fiscal Year: 1999
    ..How do mast cell proteases degrade human intestinal smooth muscle cell procollagen to collagen, and do the propeptide products of this cleavage regulate procollagen expression in human intestinal smooth muscle cells? ..
  9. COLONIC CRYPT PERMEABILITY BARRIER IN CROHNS DISEASE
    Satish Singh; Fiscal Year: 2000
    ..abstract_text> ..
  10. Identifying Disease Variants for Familial Crohns Disease
    Steven R Brant; Fiscal Year: 2010
    ..With this study, we will test 9000 gene markers in these regions and identify the specific genes and, by gene sequencing, the specific DNA abnormalities that result in a significant proportion of familial Crohn's disease. ..
  11. The Human Microbiome in Pediatric Abdominal Pain and Intestinal Inflammation
    James Versalovic; Fiscal Year: 2009
    ..of healthy children and children with irritable bowel syndrome, constipation, and inflammatory bowel disease (Crohn disease), multiple strategies will be deployed to navigate and understand the nature of the intestinal microbiome in ..
  12. VASCULAR ENDOTHELIAL CADHERIN FUNCTION IN INFLAMMATION
    SUNIL SHAW; Fiscal Year: 2003
    ..Research: Gastritis, ulceration, celiac sprue, Crohn disease and ulcerative colitis, glomerulonephritis, interstitial nephritis and pyelonephritis are all characterized by ..
  13. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
  14. IMURAN Dose Ranging Study in Crohn's Disease
    BRUCE SANDS; Fiscal Year: 2005
    ..Abstract Not Provided ..
  15. OSCCAR: A Novel, Population-based Prospective Inception Cohort of Inflammatory Bo
    BRUCE SANDS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. IMMUNOMODULATION IN INFLAMMATORY BOWEL DISEASE
    BRUCE SANDS; Fiscal Year: 2004
    ..The principal investigator seeks to become an independent clinical investigator by completing the didactic and scientific portions of this proposal. ..
  17. Effects of naltrexone on active Crohn's disease
    Jill Smith; Fiscal Year: 2007
    ..Durability of response will be evaluated in a 1-month follow-up. This trial is based upon novel innovative preclinical and clinical data and may lead to a larger multi-center trial in the future. [unreadable] [unreadable] [unreadable]..
  18. Cytokine Regulation of Growth Hormone Signaling
    LEE ARMISTEAD DENSON; Fiscal Year: 2010
    ..If the proposed studies support the utility of TNF blockade in reversing GH resistance in colitis, these findings should translate into improved clinical therapies for children with IBD. ..
  19. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2008
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  20. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2006
    ..abstract_text> ..
  21. The Natural History of Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..abstract_text> ..
  22. Effects of silencing RNAs for gastrin and CCK on human pancreatic cancer
    Jill Smith; Fiscal Year: 2008
    ..These studies are the first step in bridging the results from basic science studies into the clinical realm. If shown to be effective in the animal model, we plan to proceed to treating subjects with pancreatic cancer. ..
  23. Epidemiology of Marginal Zone Lymphoma
    Lisa Herrinton; Fiscal Year: 2003
    ..abstract_text> ..
  24. International Congress of Mucosal Immunology
    Lloyd Mayer; Fiscal Year: 2005
    ..Finally, it will devote major attention to mucosal vaccine development, particularly as this elucidates the search for a HIV vaccine. Overall, the Congress is a major and necessary part of the intellectual landscape of mucosal immunity. ..
  25. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2005
    ..Ultimately, the outcome of this study will go a long way toward clearing up the MAP debate. ..
  26. GASTROINTESTINAL PEPTIDES AND PANCREATIC CANCER
    Jill Smith; Fiscal Year: 2004
    ..These studies are part of the team's long-term goal to understand the mechanisms involved in the biology of human pancreatic cancer, and contribute to the treatment and early detection of this malignancy. ..
  27. Multi-site Trial of Azathioprine Dosing in Crohn Disease
    Stephen Hanauer; Fiscal Year: 2003
    ..Predictive models will be performed to assess responsiveness based upon initial and inducible TPMT activity and achievable 6-TGN and 6-MMPR metabolite based upon incremental AZA dosing. ..
  28. Oral Tolerance: Mechanisms and Applications
    Lloyd Mayer; Fiscal Year: 2003
    ....
  29. Autophagy in Tuberculosis
    VOJO P DERETIC; Fiscal Year: 2011
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
  30. Mechanisms of Bone Loss in Pediatric Crohn Disease
    Francisco Sylvester; Fiscal Year: 2008
    Our application proposes to examine the mechanisms by which bone formation is impaired in pediatric Crohn disease. Crohn disease is a chronic inflammatory disorder of the gastrointestinal tract...
  31. CLOTRIMAZOLE ENEMAS FOR POUCHITIS IN CHILDREN AND ADULTS
    PAUL RUFO; Fiscal Year: 2005
    ..Abstract Not Provided ..
  32. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  33. FUNCTIONAL ROLE OF IA ON GI TRACT EPITHELIAL CELLS
    Lloyd Mayer; Fiscal Year: 2004
    ..Specific Aim #3. To further characterize the regulation of gp180 expression on intestinal epithelial cells and define a potential role for this molecule on non-IECs. ..
  34. CLOTRIMAZOLE THERAPY FOR HUMAN DIARRHEAL DISEASES
    PAUL RUFO; Fiscal Year: 2003
    ..To receive formal training in biostatistics, epidemiology, and research ethics, Dr. Rufo will complete a Masters of Medical Sciences degree program at Harvard Medical School. ..
  35. INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLS
    Lloyd Mayer; Fiscal Year: 2007
    ..abstract_text> ..
  36. The Cholecystokinin-C (CCK-C) Receptor for Early Detection of Pancreatic Cancer
    Jill P Smith; Fiscal Year: 2010
    ..These studies are part of the applicant's long- term goals to understand the mechanisms controlling growth of pancreatic cancer and to diagnose patients in early stage of disease to improve long-term survival. ..
  37. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2006
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  38. Cytokine Regulation of Liver Growth Hormone Signaling
    Lee Denson; Fiscal Year: 2004
    ..These findings will have implications for therapeutic strategies to ameliorate acquired GH resistance in diseases complicated by liver inflammation, including chronic cholestatic liver diseases ..
  39. Treatment of Advanced Pancreatic Cancer with Growth Fac*
    Jill Smith; Fiscal Year: 2005
    ..Abstract Not Provided ..
  40. Multi-site Trial of Azathioprine Dosing in Crohn Disease
    Stephen Hanauer; Fiscal Year: 2004
    ..Predictive models will be performed to assess responsiveness based upon initial and inducible TPMT activity and achievable 6-TGN and 6-MMPR metabolite based upon incremental AZA dosing. ..
  41. Pilot study on the safety and efficacy of ciprofloxacin for prophylactic preventi
    Hans Herfarth; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. The Role of Adenosine Receptors in Th Cell Development and Function
    Peter Ernst; Fiscal Year: 2008
    ..abstract_text> ..
  43. Analysis of Genetic Susceptibility to Anterior Uveitis
    TAMMY MARTIN; Fiscal Year: 2009
    ..Specific Aim 3: To identify specific candidate gene mutations by using SNP marker analysis, by comparative DNA sequencing and by denaturing HPLC analysis. ..
  44. TRANSCRIPTIONAL REGULATION OF THE IMMUNE RESPONSE
    LAURIE HOLLIS GLIMCHER; Fiscal Year: 2010
    ..4) Examine the role of XBP-1 in autoimmune disease.5) Investigate the requirement of XBP-1 for the development and propagation of plasma cell neoplasms. ..
  45. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  46. Health and School Performance Among Youth Ages 9-13
    Christopher Forrest; Fiscal Year: 2009
    ..Our long-term goal for this research is to follow youth into high school and beyond to more fully characterize the evolution of health from childhood to adulthood. ..
  47. Genetic basis of IBD susceptibility & steroid response
    Stephen Guthery; Fiscal Year: 2008
    ..The candidate will enroll in the K30 program. Thus the University of Utah provides an ideal environment for maximizing the potential of this study and the candidate. ..
  48. REGULATION OF INFLAMMATORY RESPONSES
    Andreas Reimold; Fiscal Year: 2002
    ..This knowledge will be applied to the HTLV-1-transgenic mouse model of rheumatoid arthritis to assess if a dominant-negative mutant of hXBP-1 reduces joint inflammation. ..
  49. HIV Neuroprotection Workshop
    Joseph Berger; Fiscal Year: 2004
    ..The proposed conference is the first of its kind to highlight neuroprotection in HIV CNS and PNS disorders. By coupling this meeting with the International Symposium on Neurovirology this synergy can be exploited. ..
  50. Responses of Intestinal Stem Cells to Epithelial Injury
    Thaddeus Stappenbeck; Fiscal Year: 2005
    ..The resulting datasets will provide a molecular picture of signaling pathways active in colonic epithelial stem cells during wound healing and epithelial-mesenchymal crosstalk that occurs during this physiologic response to injury ..
  51. Crohn's Disease Gene Mapping of Chromosome 16
    STEVEN BRANT; Fiscal Year: 2005
    ..Defining the IBD1 mutation for CD will be a major step in unraveling the etiology and pathophysiology of this enigmatic disease, improve genetic counseling and make possible novel preventative and therapeutic strategies. ..
  52. CNS specific Knock-out and Multidrug Transport
    RODNEY HO; Fiscal Year: 2006
    ..The potential benefits to overall biomedical research outweigh the calculated risks associated with this exploratory research. ..
  53. Mechanisms ot Maternal Immune Tolerence
    Laurie Glimcher; Fiscal Year: 2006
    ..abstract_text> ..
  54. ANTIGENIC DETERMINANTS OF VARICELLA VIRUS
    Charles Grose; Fiscal Year: 2006
    ..These proposed VZV studies will provide further insight into the multiple functions of gE and the gE:gI complex. ..
  55. A Genetic Model of Uveitis
    TAMMY MARTIN; Fiscal Year: 2006
    ..Both transgenic mice and transgenic mice crossed with NOD2 knock-out mice will be studied. [unreadable] [unreadable] [unreadable]..
  56. Adaptive Function Estimation for Genomic Data
    Charles Kooperberg; Fiscal Year: 2006
    ..In addition, we plan to develop methods to improve inference for polynomial spline methodologies. ..
  57. IPformatics: An Integrated Knowledgebase of Patent Claims and Genomic Data
    Patrick Gillevet; Fiscal Year: 2006
    ..It will also have commercial value to the biotechnology industry as a resource to readily determine the patent rights that exist in human genes when developing new products and research initiatives. [unreadable] [unreadable]..
  58. MUCOSAL LYMPHOKINES IN INFLAMMATORY BOWEL DISEASE
    Claudio Fiocchi; Fiscal Year: 2008
    ..We believe this proposal provides a novel conceptual framework that will allow a more detailed and mechanistic understanding of IBD pathogenesis. ..
  59. Vitamin D and Barrier Function
    Martin Hewison; Fiscal Year: 2008
    ..abstract_text> ..
  60. Sphingosine Kinase Inhibitors as Anti-Retinopathy Agents
    LYNN MAINES; Fiscal Year: 2008
    ..This will provide rapid evaluation of the first-in-class inhibitor of this innovative molecular target. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  61. T LYMPHOCYTE ACTIVATION, DIFFERENTIATION AND DEATH
    Laurie Glimcher; Fiscal Year: 2002
    ..The Keystone Symposia has the advantage of allowing a large number of junior scientists and scientists in training to attend while being focused under a single theme, in this case T lymphocyte activation, signaling and death. ..