inflammatory bowel diseases

Summary

Summary: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.

Top Publications

  1. ncbi Mucosal flora in inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, Berlin, Germany
    Gastroenterology 122:44-54. 2002
  2. pmc Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease
    M P Conte
    Paediatric Gastroenterology Unit, University of Rome La Sapienza, Viale Regina Elena 324, Rome 00161, Italy
    Gut 55:1760-7. 2006
  3. doi Microbial influences in inflammatory bowel diseases
    R Balfour Sartor
    Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Gastroenterology 134:577-94. 2008
  4. pmc A human gut microbial gene catalogue established by metagenomic sequencing
    Junjie Qin
    BGI Shenzhen, Shenzhen 518083, China
    Nature 464:59-65. 2010
  5. ncbi Inflammatory bowel disease
    Daniel K Podolsky
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 347:417-29. 2002
  6. ncbi Unravelling the pathogenesis of inflammatory bowel disease
    R J Xavier
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, and, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 448:427-34. 2007
  7. ncbi Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
    Edward V Loftus
    Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 126:1504-17. 2004
  8. doi Intestinal homeostasis and its breakdown in inflammatory bowel disease
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 474:298-306. 2011
  9. pmc Increased expression of interleukin 17 in inflammatory bowel disease
    S Fujino
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Gut 52:65-70. 2003
  10. pmc Homeostasis and inflammation in the intestine
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 140:859-70. 2010

Detail Information

Publications403 found, 100 shown here

  1. ncbi Mucosal flora in inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, Berlin, Germany
    Gastroenterology 122:44-54. 2002
    ..Microorganisms that directly interact with the intestinal mucosa are obscured by fecal flora and poorly characterized...
  2. pmc Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease
    M P Conte
    Paediatric Gastroenterology Unit, University of Rome La Sapienza, Viale Regina Elena 324, Rome 00161, Italy
    Gut 55:1760-7. 2006
    ..No paediatric reports are available on intestinal endogenous microflora in IBD...
  3. doi Microbial influences in inflammatory bowel diseases
    R Balfour Sartor
    Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Gastroenterology 134:577-94. 2008
    ..Altered microbial composition and function in inflammatory bowel diseases result in increased immune stimulation, epithelial dysfunction, or enhanced mucosal permeability...
  4. pmc A human gut microbial gene catalogue established by metagenomic sequencing
    Junjie Qin
    BGI Shenzhen, Shenzhen 518083, China
    Nature 464:59-65. 2010
    ..We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions present in all individuals and most bacteria, respectively...
  5. ncbi Inflammatory bowel disease
    Daniel K Podolsky
    Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 347:417-29. 2002
  6. ncbi Unravelling the pathogenesis of inflammatory bowel disease
    R J Xavier
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, and, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 448:427-34. 2007
    ..Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD...
  7. ncbi Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
    Edward V Loftus
    Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 126:1504-17. 2004
    ..Additional epidemiologic studies to define better the burden of illness, explore the mechanism of association with environmental factors, and identify new risk factors are needed...
  8. doi Intestinal homeostasis and its breakdown in inflammatory bowel disease
    Kevin J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 474:298-306. 2011
    ..Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease...
  9. pmc Increased expression of interleukin 17 in inflammatory bowel disease
    S Fujino
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Gut 52:65-70. 2003
    ..Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory activities. In this study we evaluated changes in IL-17 expression in the inflamed mucosa and in the serum of patients with inflammatory bowel disease (IBD)...
  10. pmc Homeostasis and inflammation in the intestine
    Wendy S Garrett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell 140:859-70. 2010
    ..In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost...
  11. pmc CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
    Suzanne Lesage
    Fondation Jean Dausset CEPH, 27 rue Juliette Dodu, 75010 Paris, France
    Am J Hum Genet 70:845-57. 2002
    ..These findings provide tools for a DNA-based test of susceptibility and for genetic counseling in inflammatory bowel disease...
  12. pmc Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    Erik Oliver Glocker
    Department of Immunology, Royal Free Hospital and University College London, United Kingdom
    N Engl J Med 361:2033-45. 2009
    ..The molecular cause of inflammatory bowel disease is largely unknown...
  13. pmc Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases
    Christopher D Packey
    Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Curr Opin Infect Dis 22:292-301. 2009
    The authors present evidence published during the past 2 years of the roles of commensal and pathogenic bacteria in the pathogenesis of the inflammatory bowel diseases.
  14. pmc The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications
    J Satsangi
    Gstrointestinal Unit, Western General Hospital, University of Edinburg, UK
    Gut 55:749-53. 2006
    In recent years, investigators have readdressed the complex issues involved in the classification of inflammatory bowel diseases. In 2003, a Working Party of investigators with an interest in the issues involved in disease ..
  15. pmc Genetics and pathogenesis of inflammatory bowel disease
    Bernard Khor
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 474:307-17. 2011
    ....
  16. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  17. doi Cytokine blockade in inflammatory bowel diseases
    Clémentine Perrier
    Division of Gastroenterology, University Hospital, Catholic University Leuven, Leuven, Belgium
    Immunotherapy 3:1341-52. 2011
    b>Inflammatory bowel diseases (IBDs) are chronic disabling diseases with significant morbidity...
  18. pmc Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    Daniel N Frank
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Proc Natl Acad Sci U S A 104:13780-5. 2007
    The two primary human inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), are idiopathic relapsing disorders characterized by chronic inflammation of the intestinal tract...
  19. doi Probiotics and the gut microbiota in intestinal health and disease
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Gastroenterol Hepatol 7:503-14. 2010
    ..An overview of recent in vitro and in vivo research related to potential mechanisms of action of various probiotic formulations is also considered...
  20. doi Fungi and inflammatory bowel diseases: Alterations of composition and diversity
    Stephan J Ott
    Institute for Clinical Molecular Biology, Christian Albrechts University CAU, Kiel, Germany
    Scand J Gastroenterol 43:831-41. 2008
    ..may reflect the net influence of lifestyle factors associated with the development of chronic inflammatory bowel diseases (IBD)...
  21. ncbi Inflammatory bowel disease: cause and immunobiology
    Daniel C Baumgart
    Department of Medicine, Division of Gastroenterology and Hepatology, Charité Medical Centre, Virchow Hospital, Medical School of the Humboldt University of Berlin, 13344 Berlin, Germany
    Lancet 369:1627-40. 2007
    ..Implications for novel therapies, which are discussed in detail in the second paper in this Series, are covered briefly...
  22. pmc Toll-like receptors in inflammatory bowel diseases: a decade later
    Elke Cario
    Division of Gastroenterology and Hepatology, University Hospital of Essen, and Medical School, University of Duisburg Essen, Essen, Germany
    Inflamm Bowel Dis 16:1583-97. 2010
    ..Imbalanced relationships within this triad may promote aberrant TLR signaling, critically contributing to acute and chronic intestinal inflammatory processes in IBD colitis and associated cancer...
  23. pmc Role of cytokines in inflammatory bowel disease
    Fausto Sanchez-Munoz
    World J Gastroenterol 14:4280-8. 2008
    ..Cytokines levels in time and space orchestrate the development, recurrence and exacerbation of the inflammatory process in IBD. Therefore, several cytokine therapies have been developed and tested for the treatment of IBD patients...
  24. ncbi Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics
    R Balfour Sartor
    Department of Medicine, Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27599 7032 USA
    Gastroenterology 126:1620-33. 2004
    ..Current clinical trials do not fulfill evidence-based criteria for using these agents in inflammatory bowel diseases (IBD), but multiple nonrigorous studies and widespread clinical experience suggest that metronidazole ..
  25. ncbi Mucosal healing in inflammatory bowel diseases: a systematic review
    Markus F Neurath
    Professor of Medicine, Department of Medicine I, University of Erlangen Nuremberg, Ulmenweg 18, Erlangen, Germany
    Gut 61:1619-35. 2012
    ..studies have identified mucosal healing on endoscopy as a key prognostic parameter in the management of inflammatory bowel diseases (IBD), thus highlighting the role of endoscopy for monitoring of disease activity in IBD...
  26. doi Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
    Raffaella M Gadaleta
    Department of Gastroenterology and Hepatology, UMC Utrecht, The Netherlands
    Gut 60:463-72. 2011
    ..The aim of this study was to investigate the therapeutic potential of FXR agonists in the treatment of intestinal inflammation in complementary in vivo and in vitro models...
  27. ncbi Microbial host interactions in IBD: implications for pathogenesis and therapy
    R Balfour Sartor
    Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, CB 7032, Room 7309, Medical Biomolecular Research Building, Chapel Hill, NC 27599, USA
    Curr Gastroenterol Rep 9:497-507. 2007
    ....
  28. pmc Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 USA
    Immunity 29:947-57. 2008
    ..In addition, IL-22 expression was differentially regulated between NK cell subsets. Thus, both the innate and adaptive immune responses have developed protective mechanisms to counteract the damaging effects of inflammation on tissues...
  29. pmc Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
    S J Ott
    Department of General Internal Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Gut 53:685-93. 2004
    ..As most of the colonic bacteria cannot be identified by culture techniques, genomic technology can be used for analysis of the composition of the microflora...
  30. doi Intestinal barrier dysfunction in inflammatory bowel diseases
    Michael A McGuckin
    Mucosal Diseases Program, Mater Medical Research Institute, University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia
    Inflamm Bowel Dis 15:100-13. 2009
    The etiology of human inflammatory bowel diseases (IBDs) is believed to involve inappropriate host responses to the complex commensal microbial flora in the gut, although an altered commensal flora is not completely excluded...
  31. ncbi Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
    Josep Bassaganya-Riera
    Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Gastroenterology 127:777-91. 2004
    ..We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism...
  32. ncbi Diagnostics of inflammatory bowel disease
    Susanna Nikolaus
    Department of General Internal Medicine, Christian Albrechts University, Kiel, Germany
    Gastroenterology 133:1670-89. 2007
    ..It can be expected that future diagnostic algorithms will include molecular parameters to detect early disease or guide therapies by predicting the individual course of disease...
  33. doi Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Mol Nutr Food Res 52:885-97. 2008
    ..Fish oil supplementation in patients with inflammatory bowel diseases results in n-3 PUFA incorporation into gut mucosal tissue and modification of inflammatory mediator ..
  34. doi Guidelines for the management of inflammatory bowel disease in adults
    Craig Mowat
    Gastrointestinal Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Gut 60:571-607. 2011
    ..ecco-ibd.eu/index.php (accessed Oct 2010)...
  35. pmc Hypoxia: an alarm signal during intestinal inflammation
    Sean P Colgan
    Division of Gastroenterology, Mucosal Inflammation Program, University of Colorado Denver, 12700 E 19th Avenue MS B146, Aurora, CO 80045, USA
    Nat Rev Gastroenterol Hepatol 7:281-7. 2010
    ..We also discuss the pros and cons of targeting these pathways to treat patients with IBD...
  36. doi The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models
    Sandra Nell
    Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Rev Microbiol 8:564-77. 2010
    ..In this Review, we focus on the impact of pathogenic and commensal bacteria on IBD-like pathogenesis in mouse infection models and summarize important recent developments...
  37. doi Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
    Yukihide Momozawa
    Unit of Animal Genomics, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    Nat Genet 43:43-7. 2011
    ....
  38. doi Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria
    Chin Wen Png
    Mater Medical Research Institute and Department of Medicine, University of Queensland, Mater Health Services, South Brisbane, Queensland, Australia
    Am J Gastroenterol 105:2420-8. 2010
    ..We hypothesized that mucolytic bacteria are increased in IBD, providing increased substrate to sustain nonmucolytic mucosa-associated bacteria...
  39. doi Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease
    Paul Henderson
    Department of Child Life and Health, University of Edinburgh, Edinburgh, UK
    Inflamm Bowel Dis 17:382-95. 2011
    ..The inflammatory bowel diseases (IBDs) are characterized by inflammation at this mucosal surface with well-recognized defects in ..
  40. ncbi Angiogenesis as a novel component of inflammatory bowel disease pathogenesis
    Silvio Danese
    Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy
    Gastroenterology 130:2060-73. 2006
    ..We assessed mucosal vascularization, expression of endothelial alphaVbeta3 integrin, angiogenic factors, and their bioactivity in Crohn's disease (CD) and ulcerative colitis (UC) mucosa...
  41. doi Antibiotic use and inflammatory bowel diseases in childhood
    Anders Hviid
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Gut 60:49-54. 2011
    ..composition of the intestinal microflora has been proposed as an important factor in the development of inflammatory bowel diseases (IBD). Antibiotics have the potential to alter the composition of the intestinal microflora...
  42. pmc TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases
    Mirjam Schenk
    Division of Immunopathology, Institute of Pathology, University of Bern, Bern, Switzerland
    J Clin Invest 117:3097-106. 2007
    ..Here we demonstrate that TREM-1 is also crucially involved in chronic inflammatory bowel diseases (IBD). Myeloid cells of the normal intestine generally lack TREM-1 expression...
  43. pmc Translatability of helminth therapy in inflammatory bowel diseases
    Joel V Weinstock
    Division of Gastroenterology, Tufts Medical Center, Boston, MA, USA
    Int J Parasitol 43:245-51. 2013
    ..These efforts could soon result in new therapies for patients with IBD...
  44. pmc Recent trends in the epidemiology of inflammatory bowel diseases: up or down?
    Peter Laszlo Lakatos
    1st Department of Medicine, Semmelweis University, Koranyi str 2 A, H 1083, Hungary
    World J Gastroenterol 12:6102-8. 2006
    ..The quality of studies is also variable. Additional epidemiologic studies are needed to better define the burden of illness, explore the mechanism of association with environmental factors, and identify new risk factors...
  45. ncbi The role of stress in the development and clinical course of inflammatory bowel disease: epidemiological evidence
    Robert G Maunder
    Department of Psychiatry, Mount Sinai Hospital, 600 University Ave, Toronto, Canada, M5G 1X5
    Curr Mol Med 8:247-52. 2008
    It is unclear whether psychological stress contributes to the inflammatory process in the inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD)...
  46. pmc PPARgamma as a new therapeutic target in inflammatory bowel diseases
    L Dubuquoy
    INSERM U795 ex E114, Clinique des maladies de l appareil digestif et de la nutrition, Hôpital Swynghedauw, Rue A Verhaeghe, F 59037 Lille Cedex, France
    Gut 55:1341-9. 2006
    ..that PPARgamma was the major functional receptor mediating the common aminosalicylate activities in inflammatory bowel diseases (IBD) have also reinforced the roles of this receptor in the control of intestinal inflammation...
  47. doi Mucins in inflammatory bowel diseases and colorectal cancer
    Yong H Sheng
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    J Gastroenterol Hepatol 27:28-38. 2012
    ..barrier function of mucus and could play roles in initiating and maintaining mucosal inflammation in inflammatory bowel diseases (IBD), and in driving cancer development in the intestine...
  48. doi Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease
    Silvia Melgar
    Department of Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Int Immunopharmacol 8:836-44. 2008
    ..Thus, three of the current tested agents showed efficacy in the disease model, arguing that DSS-induced colitis can be used as a relevant model for the translation of mice data to human disease...
  49. pmc Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    D J Berg
    Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Clin Invest 98:1010-20. 1996
    ..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain...
  50. pmc Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression
    Andrea Paradisi
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Proc Natl Acad Sci U S A 106:17146-51. 2009
    Chronic inflammation and cancer are intimately associated. This is particularly true for inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, which show a major increased risk for colorectal cancer...
  51. doi A microbial symbiosis factor prevents intestinal inflammatory disease
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 453:620-5. 2008
    ..Harnessing the immunomodulatory capacity of symbiosis factors such as PSA might potentially provide therapeutics for human inflammatory disorders on the basis of entirely novel biological principles...
  52. pmc Laboratory markers in IBD: useful, magic, or unnecessary toys?
    S Vermeire
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Gut 55:426-31. 2006
    ..They are however not magic and until more data become available, the use of CRP and other laboratory markers should be seen as an additive tool to clinical observation and physical examination rather than a replacement...
  53. pmc CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice
    Susan E Erdman
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Pathol 162:691-702. 2003
    b>Inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, increase the risk of colorectal cancer in humans...
  54. ncbi Mouse models of inflammatory bowel disease
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
    Adv Drug Deliv Rev 59:1073-83. 2007
    ..In this article we provide a brief overview of selected mouse models of IBD and discuss their contribution to the current understanding of disease mechanisms that contribute to IBD...
  55. doi Depression and anxiety in inflammatory bowel disease: a review of comorbidity and management
    Lesley A Graff
    Department of Clinical Health Psychology, University of Manitoba, Winnipeg, Manitoba, Canada
    Inflamm Bowel Dis 15:1105-18. 2009
    ..We review evidence-based pharmacological and psychological treatments for anxiety and depression and discuss practical considerations in treating these conditions in the context of IBD to facilitate overall management of the IBD patient...
  56. doi TGF-beta1 and Smad7 in the regulation of IBD
    G Monteleone
    Department of Internal Medicine, University Tor Vergata of Rome, Rome, Italy
    Mucosal Immunol 1:S50-3. 2008
    b>Inflammatory bowel diseases (IBDs) are caused by an aberrant and excessive local immune response to components of the bacterial microflora that are: poorly controlled by endogenous counter regulatory mechanisms such as the ..
  57. pmc Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
    B von Lampe
    Medizinische Klinik I Gastroenterologie und Infektiologie, Klinikum Benjamin Franklin, FU Berlin, Hindenburgdamm 30, 12200 Berlin, FRG
    Gut 47:63-73. 2000
    ..The current study was therefore designed to determine gene expression patterns of MMPs and their tissue inhibitors (TIMPs) in single endoscopic biopsies of patients with inflammatory bowel disease (IBD)...
  58. pmc Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease
    Mayumi Kawada
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA 02114, USA
    World J Gastroenterol 13:5581-93. 2007
    ..We also summarize some regulatory and pathogenic factors demonstrated by these models that can, hopefully, be exploited to develop future therapeutic strategies against IBD...
  59. ncbi Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis
    M Mahler
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Am J Physiol 274:G544-51. 1998
    ..Knowledge of these strain differences in genetic responsiveness to acute inflammatory stress in the large intestine will permit design of genetic crosses to elucidate the genes involved...
  60. pmc Etiopathogenesis of inflammatory bowel diseases
    Silvio Danese
    Division of Gastroenterology, Istituto Clinico Humanitas IRCCS in Gastroenterology, Milan, Italy
    World J Gastroenterol 12:4807-12. 2006
    ..Gut inflammation is mediated by cells of the innate as well as adaptive immune systems, with the additional contribution of non-immune cells, such as epithelial, mesenchymal and endothelial cells, and platelets...
  61. ncbi Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials
    Charlotte Hedin
    Nutritional Sciences Division, King s College London, London SE1 9NH, UK
    Proc Nutr Soc 66:307-15. 2007
    ..The present article reviews the role of the intestinal microbiota in the pathogenesis of IBD and addresses the clinical evidence for the therapeutic manipulation of bowel microbiota using probiotics, prebiotics and synbiotics in IBD...
  62. ncbi Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices
    Jost Langhorst
    Department of Internal and Integrative Medicine, Kliniken Essen Mitte, University of Duisburg Essen, Germany
    Am J Gastroenterol 103:162-9. 2008
    ..neutrophil elastase (PMN-e), as well as serum C-reactive protein (CRP) in patients with inflammatory bowel diseases (IBD) to address (a) whether these markers can differentiate IBD patients with endoscopically assessed ..
  63. ncbi The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 450:566-9. 2007
    ..Taken together, these data identify IL-35 as a novel inhibitory cytokine that may be specifically produced by T(reg) cells and is required for maximal suppressive activity...
  64. ncbi The immunological and genetic basis of inflammatory bowel disease
    Gerd Bouma
    The Mucosal Immunity Section, National Institutes of Health, Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institutes of Allergy and Infectious Diseases, 10 Center Drive, Room 11N238, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 3:521-33. 2003
    The inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, are chronic inflammatory disorders of the gastrointestinal tract...
  65. doi Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature
    Jason K Hou
    Section of Gastroenterology, Baylor College of Medicine, Houston, TX, USA
    Am J Gastroenterol 106:563-73. 2011
    ..Although many studies have evaluated the association between diet and IBD risk, there has been no systematic review...
  66. pmc Iron, anaemia, and inflammatory bowel diseases
    C Gasche
    Department of Medicine 4, Division of Gastroenterology and Hepatology, Medical University Vienna, Austria
    Gut 53:1190-7. 2004
    ..It is our experience that virtually all patients with IBD associated anaemia can be successfully treated with a combination of iron sucrose and erythropoietin, which then may positively affect the misled immune response in IBD...
  67. ncbi Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
    Steven H Itzkowitz
    Gastrointestinal Division, Box 1069, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Physiol Gastrointest Liver Physiol 287:G7-17. 2004
    ..date, no known genetic basis has been identified to explain colorectal cancer predisposition in these inflammatory bowel diseases. Instead, it is assumed that chronic inflammation is what causes cancer...
  68. pmc The fundamental basis of inflammatory bowel disease
    Warren Strober
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:514-21. 2007
    Two broad hypotheses have arisen regarding the fundamental nature of the pathogenesis of inflammatory bowel diseases (IBDs, which include ulcerative colitis and Crohn disease)...
  69. doi Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria
    Chen Varol
    Gastroenterology and Hepatology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Nat Rev Immunol 10:415-26. 2010
    ..evolved to maintain peaceful coexistence at this site, the breakdown of which can result in devastating inflammatory bowel diseases (IBDs)...
  70. doi Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice
    Reiko Ito
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 377:12-6. 2008
    ..The present results show that IL-17A plays a pivotal role in the pathogenesis of DSS-induced colitis, while MCP-1 and G-CSF may be crucially involved in the IL-17A-induced inflammation...
  71. ncbi Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease
    Anje A te Velde
    Center of Experimental and Molecular Medicine, AMC, Amsterdam, The Netherlands
    Inflamm Bowel Dis 13:325-30. 2007
    Mouse models of inflammatory bowel diseases (IBD) are used to unravel the pathophysiology of IBD and to study new treatment modalities, but their relationship to Crohn's disease (CD) or ulcerative colitis (UC) is speculative.
  72. ncbi Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease
    Robert W Summers
    Department of Internal Medicine, James A Clifton Center for Digestive Diseases, University of Iowa Health Care, Iowa City, Iowa, USA
    Am J Gastroenterol 98:2034-41. 2003
    ..Induction of a Th2 immune response by intestinal helminths diminishes Th1 responsiveness. This study evaluates the safety and effectiveness of helminthic ova in the treatment of active IBD...
  73. pmc Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease
    Eliseo Papa
    Harvard MIT Health Science and Technology Institute, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e39242. 2012
    ..We investigated the use of 16S rRNA sequencing of fecal samples and new analytical methods to assess differences in the microbiota of children with IBD and other gastrointestinal disorders...
  74. doi Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification
    Arie Levine
    Wolfson Medical Center, Tel Aviv University, Israel
    Inflamm Bowel Dis 17:1314-21. 2011
    ..The dynamic features of pediatric disease phenotype (change in disease location and behavior over time, growth failure) are not sufficiently captured by the current Montreal Classification...
  75. pmc XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    Arthur Kaser
    Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Cell 134:743-56. 2008
    ..Hence, intestinal inflammation can originate solely from XBP1 abnormalities in IECs, thus linking cell-specific ER stress to the induction of organ-specific inflammation...
  76. doi Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease
    J L Anderson
    Diabetes and Nutritional Sciences Division, School of Medicine, King s College London, London, UK
    Aliment Pharmacol Ther 36:503-16. 2012
    ..The intestinal microbiota is involved in the pathogenesis of inflammatory bowel disease (IBD). Faecal microbiota transplantation (FMT) has been used for the management of IBD as well as infectious diarrhoea...
  77. pmc Blocking lymphocyte localization to the gastrointestinal mucosa as a therapeutic strategy for inflammatory bowel diseases
    Eduardo J Villablanca
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 140:1776-84. 2011
    ..specific tissues has an important role during protective and pathological immune responses, including inflammatory bowel diseases. Lymphocytes use integrin α4β7 and the chemokine receptor CCR9 to localize to the gastrointestinal ..
  78. doi Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr1a(-/-) mice, a model of inflammatory bowel diseases
    Gunaranjan Paturi
    The New Zealand Institute for Plant and Food Research Limited, Private Bag 92169, Auckland 1142, New Zealand
    Nutrition 28:324-30. 2012
    ..This study aimed to determine the anti-inflammatory colonic effects of blueberries and broccoli in mdr1a(-/-) mice (IBD mouse model) through modification of microbiota composition in the gastrointestinal tract...
  79. ncbi Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases
    Christoph Gasche
    Division of Gastroenterology and Hepatology, Medical University of Vienna, Austria
    Inflamm Bowel Dis 13:1545-53. 2007
    Anemia is a common complication of inflammatory bowel diseases. An international working party has formed and developed guidelines for evaluation and treatment of anemia and iron deficiency that should serve practicing ..
  80. doi Probiotics for the treatment of inflammatory bowel disease
    Ganesh R Veerappan
    Gastroenterology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD 20889 0001, USA
    Curr Gastroenterol Rep 14:324-33. 2012
    ..More rigorous studies need to be published supporting efficacy and safety of these agents before they become a mainstay of IBD medical treatment...
  81. pmc Innate and adaptive immunity in inflammatory bowel disease
    Britta Siegmund
    Medical Department I Gastroenterology Rheumatology Infectious Diseases, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany
    World J Gastroenterol 17:3178-83. 2011
    b>Inflammatory bowel diseases are the consequence of a dysregulated mucosal immune system. The mucosal immune system consists of two arms, innate and adaptive immunity, that have been studied separately for a long time...
  82. ncbi Smoking and inflammatory bowel disease: a meta-analysis
    Suhal S Mahid
    Department of Surgery, Section of Colorectal Surgery, Price Institute of Surgical Research, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Mayo Clin Proc 81:1462-71. 2006
    ..To assess whether there is a true effect of smoking on the 2 most prevalent forms of inflammatory bowel disease (IBD): Crohn disease (CD) and ulcerative colitis (UC)...
  83. pmc Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression
    Jean Eric Ghia
    Intestinal Diseases Research Programme, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 118:2209-18. 2008
    ....
  84. pmc Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition
    Ellen Li
    Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 7:e26284. 2012
    ..ileal biopsies collected from 52 ileal CD, 58 ulcerative colitis and 60 control patients without inflammatory bowel diseases (IBD) undergoing initial surgical resection...
  85. pmc Dysbiosis in inflammatory bowel disease
    C P Tamboli
    Division of Gastroenterology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Gut 53:1-4. 2004
    Abundant data have incriminated intestinal bacteria in the initiation and amplification stages of inflammatory bowel diseases. However, the precise role of intestinal bacteria remains elusive...
  86. doi Pancreatitis in inflammatory bowel diseases
    C S Pitchumoni
    Gastroenterology, Hepatology, and Clinical Nutrition, Saint Peters University Hospital, New Brunswick, NJ, USA
    J Clin Gastroenterol 44:246-53. 2010
    ..The IBD-pancreas association is further reflected in many reports of exocrine as well as endocrine pancreatic insufficiency...
  87. pmc CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    A Suzuki
    Institute of Life Science, Kurume University, Kurume 839-0861, Japan
    J Exp Med 193:471-81. 2001
    ..These data suggest that hyperactivation of STAT3 results in severe colitis and that CIS3 plays a negative regulatory role in intestinal inflammation by downregulating STAT3 activity...
  88. doi FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease
    Rayko Evstatiev
    Department of Medicine 3, Division of Gastroenterology and Hepatology, Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria
    Gastroenterology 141:846-853.e1-2. 2011
    ..We compared the efficacy and safety of a novel fixed-dose ferric carboxymaltose regimen (FCM) with individually calculated iron sucrose (IS) doses in patients with inflammatory bowel disease (IBD) and IDA...
  89. ncbi Management consensus of inflammatory bowel disease for the Asia-Pacific region
    Qin Ouyang
    Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China
    J Gastroenterol Hepatol 21:1772-82. 2006
    ....
  90. pmc CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    Ashutosh Chaudhry
    Howard Hughes Medical Institute and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 326:986-91. 2009
    ..These findings suggest that T(regs) adapt to their environment by engaging distinct effector response-specific suppression modalities upon activation of STAT proteins that direct the corresponding class of the immune response...
  91. ncbi Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1157-63. 2006
    ..These results demonstrate that natural acquisition of immune responses to flagellin are regulated by TLR5 and suggest that immune responses to flagellin are not merely associated with CD but rather promote the pathogenic response...
  92. ncbi Impact of depressive mood on relapse in patients with inflammatory bowel disease: a prospective 18-month follow-up study
    Christian Mittermaier
    Department of Medicine IV, Division of Gastroenterology and Hepatology, University Hospital of Vienna, Vienna, Austria
    Psychosom Med 66:79-84. 2004
    ..We examined the influence of depressive mood and associated anxiety on the course of IBD over a period of 18 months in a cohort of patients after an episode of active disease...
  93. ncbi Role of angiogenesis in inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, Heraklion, Crete, Greece
    Inflamm Bowel Dis 12:515-23. 2006
    ..This review outlines the evidence that the rate of angiogenesis is increased in the inflamed intestine in IBD and proposes lines for future research in this field...
  94. doi Epithelial tight junctions in intestinal inflammation
    Joerg D Schulzke
    Department of General Medicine and Pathophysiology of Enteral Nutrition, Charite, Campus Benjamin Franklin, Berlin, Germany
    Ann N Y Acad Sci 1165:294-300. 2009
    ..Immune regulation of epithelial functions by cytokines may cause barrier dysfunction not only by tight junction impairments but also by apoptotic leaks, transcytotic mechanisms, and mucosal gross lesions...
  95. pmc Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases
    Daniel A Peterson
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell Host Microbe 3:417-27. 2008
    ..This review focuses on the microbial ecology of the gut in inflammatory bowel diseases and on how recent studies provide an impetus for using carefully designed, comparative metagenomic ..
  96. pmc High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
    Roman Kotlowski
    Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada
    Gut 56:669-75. 2007
    ..One way of determining which bacteria might be likely candidates is to use culture-independent methods to identify microorganisms that are present in diseased tissues but not in controls...
  97. doi Helminths and the IBD hygiene hypothesis
    Joel V Weinstock
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Inflamm Bowel Dis 15:128-33. 2009
    ..The first prototype worm therapies directed against immunological diseases are now under study in the United States and various countries around the world. Additional studies are in the advanced planning stage...
  98. doi Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
    Henri Duboc
    INSERM ERL U 1057, UMR7203, Paris, France
    Gut 62:531-9. 2013
    Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD-associated dysbiosis on BA metabolism and its influence on the epithelial cell ..
  99. doi NF-kappaB in inflammatory bowel disease
    I Atreya
    Institute of Molecular Medicine and I Medical Clinic, University of Mainz, Mainz, Germany
    J Intern Med 263:591-6. 2008
    ....
  100. doi Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer
    S Danese
    Inflammatory Bowel Disease Unit, Division of Gastroenterology, Milan, Italy
    Oncogene 29:3313-23. 2010
    ..Dissection of molecular pathways involved in colitis-associated cancer may offer opportunities for innovative therapeutic strategies...
  101. doi Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment
    Claudia Veltkamp
    Department of Gastroenterology, Hepatology and Infectious Diseases, Ruprecht Karls University, Heidelberg, Germany
    Gut 60:1345-53. 2011
    ..This study was conducted to investigate whether increased apoptosis contributes to Treg cell deficiency in IBD and whether successful treatment with antitumour necrosis factor α (TNFα) is achieved by reducing of Treg cell apoptosis...

Research Grants77

  1. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..novel inhibitors of human neutral ceramidase (ASAH2) that are effective as therapeutic agents for Inflammatory Bowel Diseases (IBDs)...
  2. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) involve chronic inflammation of all or part of the digestive tract. Symptoms may include abdominal pain, severe diarrhea and malnutrition...
  3. Ibis T-6,000 Biosensor System
    CYNTHIA SEARS; Fiscal Year: 2010
    ..diseases including respiratory disease in cancer and transplant patients, intestinal diseases such as inflammatory bowel diseases, diarrhea and colon cancer and prostate cancer...
  4. Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
    Anthony Blikslager; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The human inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, affect over one million Americans and significant unmet medical needs still exist...
  5. Regulation of Chronic Colitis by Mesenchymal Stem Cells
    Matthew B Grisham; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The inflammatory bowel diseases (IBD;Crohn's disease;ulcerative colitis) are chronic inflammatory disorders of the small bowel and/or colon that affect approximately 1...
  6. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human inflammatory bowel diseases (IBD's), including Crohn's disease and ulcerative colitis, are life-long, potentially debilitating intestina disorders thought to be due to overly-..
  7. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC) are chronic diseases characterized by a pronounced infiltration of neutrophils (PMNs) into colonic ..
  8. Analyzing Anthrax Toxins in Drosophilia
    Ethan Bier; Fiscal Year: 2013
    ..also have broad applications to a variety of barrier disruptive diseases including other infectious diseases, cardiac ischemia, asthma, dermatitis, inflammatory bowel diseases, cancer, ciliary diseases, and neurodegenerative disorders.
  9. Bacterial Stress Responses to Intestinal Inflammation
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Crohn's disease and ulcerative colitis, collectively known as inflammatory bowel diseases (IBD), are caused in part by overly-aggressive, T cell-mediated immune responses to bacterial products ..
  10. Calcium-sensing receptor signaling in the regulation of colonic epithelial cells
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2012
    ..Despite its fundamental importance for understanding the pathogenesis of human diseases, including inflammatory bowel diseases (IBD) and colorectal cancer (CRC), the signaling mechanisms involved remain incompletely understood...
  11. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2012
    ..dysplasia, and adenocarcinoma in the upper GI tract and dysplasia and adenocarcinoma of the colon in inflammatory bowel diseases in the lower GI tract...
  12. Microbial regulation of intestinal gene expression through microRNA
    Sushila Dalal; Fiscal Year: 2012
    ..interactions are complex, and microbes may also play a major role in causing conditions such as inflammatory bowel diseases (IBD)...
  13. Developing and Improving the UAB Gnotobiotic Facility.
    SAMUEL CORBIN CARTNER; Fiscal Year: 2013
    ..fundamental, and previously unobtainable, insights into the pathogenesis of many diseases including inflammatory bowel diseases (IBD;Crohn's disease and ulcerative colitis) and colon cancer...
  14. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
    ..including secretory and motility abnormalities, mucosal damage, strictures and pain that characterize inflammatory bowel diseases (IBD), particularly Crohn's, has not been well-investigated...
  15. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..This new information may have therapeutic applications for the prevention or treatment of digestive diseases triggered by infection including inflammatory bowel diseases and infectious diarrhea.
  16. CAT1920: A Small Molecule Therapeutic for the Treatment of IBD
    MICHAEL ROBERT JIROUSEK; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Inflammatory Bowel Diseases (IBD) are chronic inflammatory diseases of the digestive tract which include Crohn's Disease and ..
  17. Role of ROR??t in the transcriptional regulatory network underlying Th17 lineage
    Dan Littman; Fiscal Year: 2010
    ..therapeutic targets in inflammatory diseases linked to Th17 cell-mediated pathogenesis, including inflammatory bowel diseases, rheumatoid arthritis, multiple sclerosis, diabetes, psoriasis, and asthma...
  18. INNATE AND ADAPTIVE IMMUNITY IN IBD
    Charles O Elson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The inflammatory bowel diseases (IBD) involve complex abnormalities in the innate and adaptive immune response to the Intestinal microbiota...
  19. Pl3K Regulation of Microbicidal Pathways in Macrophages in Experimental Colitis
    Erin C Steinbach; Fiscal Year: 2013
    The human inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, result from an inappropriately directed immune response to enteric microbiota in a genetically susceptible host...
  20. Identification of Lactobacillus Secreted Factors in Regulation of Pgp
    Seema Saksena; Fiscal Year: 2013
    ..Pgp function and expression have been implicated in the pathogenesis of intestinal disorders, such as inflammatory bowel diseases (IBD) and colitis...
  21. Role of TL1A in Severity of Crohn's Disease Inflammation
    Stephan R Targan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) are the result of complex interactions between susceptibility and severity genes, the environment and the mucosal immune system...
  22. Role of stress-induced reduction in Lactobacillus reuteri on colonic inflammation
    Michael T Bailey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The inflammatory bowel diseases (IBD, including Crohn's disease and ulcerative colitis) involve disrupted homeostatic interactions between the microbiota and the mucosal immune system as a ..
  23. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2012
    ..host tissue and contribute to the pathogenesis of allergic inflammatory diseases such as asthma and inflammatory bowel diseases (IBD)...
  24. MicroRNA-mediated regulation of ATG16L1 expression and autophagy
    John Kwon; Fiscal Year: 2012
    ..Our long-term goal is to determine the role of microRNAs in the pathogenesis of inflammatory bowel diseases, such as Crohn's disease...
  25. Role of Bacteria in Colitis-associated Colon Cancer
    Christian Jobin; Fiscal Year: 2013
    ..risk factor for the development of colorectal cancer and consequently individuals suffering from inflammatory bowel diseases (IBD) are at high risk...
  26. Intestinal Lymphocyte Trafficking
    Eugene C Butcher; Fiscal Year: 2013
    ..lymphocyte recruitment to normal and inflamed intestines may lead to novel therapeutic approaches in inflammatory bowel diseases, as well as providing insights that can improve methods of vaccination and monitoring of mucosal ..
  27. Regulation of cyclooxygenase-2 by ErbB4 in colon epithelial cells
    Mark R Frey; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Inflammatory bowel diseases are associated with an increased risk of early-onset colorectal cancer, resulting in great cost both economically and in patient morbidity and mortality...
  28. Impact of Diet on Intestinal Microbiota-Host Dynamics
    Justin Sonnenburg; Fiscal Year: 2013
    ..Aberrant intestinal microbiota composition has been linked to inflammatory bowel diseases and to obesity, yet the factors contributing to microbiota alterations are currently ill defined...
  29. Novel Mucosa-homing Dendritic Cell: Development, Trafficking and Function
    Eugene C Butcher; Fiscal Year: 2013
    ..g. for HIV or rotavirus) and to control pathologic inflammation (e.g. in inflammatory bowel diseases or celiac disease).
  30. Defining the causality &biologic impact of genes within ulcerative colitis loci.
    John D Rioux; Fiscal Year: 2013
    ..This success has been most notable for the inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), where ~100 genetic risk factors have been ..
  31. Epithelial-derived mediators of neutrophil infiltration in the intestine
    ROSE LINDA SZABADY; Fiscal Year: 2013
    ..The idiopathic inflammatory bowel diseases (IBD) impose a significant health and monetary burden in the developed world, with roughly 1 in 200 ..
  32. Inflammatory Effect of Enteric Bacterial-Mediated Intestinal Permeability
    IAN MICHAEL CARROLL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) are highly prevalent intestinal diseases in the United States affecting 1.4 million individuals...
  33. Exposure to antibiotics during infancy and subsequent risk of Crohn's disease: a
    Michael D Kappelman; Fiscal Year: 2013
    ..research methodology, and a proven commitment to applying these methods to the study of the inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC)...
  34. Protease Pathways in the Gastrointestinal Tract
    Toni M Antalis; Fiscal Year: 2010
    ..contribute to barrier dysfunction underlying the pathogenesis of multiple microbial, autoimmune and inflammatory bowel diseases. The proposed studies will test the hypothesis that matriptase participates in the formation and ..
  35. Mechanisms of NaCl Absorption in the Human Colon
    Pradeep K Dudeja; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diarrhea associated with inflammatory bowel diseases (IBD) or infections by food-borne pathogens remains a major health problem in our veteran patient population...
  36. The Role of Gut and Skin Microbiome in Psoriatic Arthritis
    Jose U Scher; Fiscal Year: 2013
    ..There is strong genetic, clinical and therapy-based evidence that psoriasis, psoriatic arthritis and inflammatory bowel diseases represent examples of the same disease spectrum...
  37. Three-dimensional Scaffold-based Systems for Primary Human Intestinal Culture
    Calvin J Kuo; Fiscal Year: 2013
    ..the intestine are a considerable source of human morbidity and mortality, including but not limited to inflammatory bowel diseases, infection, malabsorptive states and neoplasia...
  38. Immunomodulatory effects of intestinal helminthes on mucosal immunity
    Hai Ning Shi; Fiscal Year: 2013
    ..indicates an inverse correlation between the incidence of certain immune-mediated diseases, including inflammatory bowel diseases (IBD), and exposure to parasitic helminths...
  39. Regulation of NF-kappaB and IKK by proinflammatory stimuli
    Michael Karin; Fiscal Year: 2013
    ..Similar mechanisms may underlie barrier deterioration in UC and CD, inflammatory bowel diseases that increase CRC risk...
  40. Targeted siRNA delivery to aberrantly activated leukocytes for treating colitis
    Motomu Shimaoka; Fiscal Year: 2010
    ..role in the pathogenesis of a wide range of autoimmune and immunological disorders including such inflammatory bowel diseases (IBD) as ulcerativecolitis andCrohn's disease...
  41. Maternal Obesity, AMPK and Development of Fetal and Neonatal Gut
    Meijun Zhu; Fiscal Year: 2012
    ..transmission of bacteria, viruses, macromolecules causing gut inflammation, pre-disposing offspring to inflammatory bowel diseases, autoimmune diseases and food allergy...
  42. INTESTINAL REGULATION OF ThPOK EXPRESSION AND CD4 HELPER T CELL FUNCTION
    DANIEL S MUCIDA; Fiscal Year: 2013
    ..of this unpredicted plasticity of helper T cells will be studied using models of infection and inflammatory bowel diseases (IBD)...
  43. Investigating the role of ROCK1 in epithelial cell inflammatory responses
    Dennis W McGee; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The inflammatory bowel diseases result in an uncontrolled inflammation of the intestine and colon, which can be worsened by a decrease ..
  44. Ponce School of Medicine - Moffitt Cancer Center Partnership
    WARREN JACKSON PLEDGER; Fiscal Year: 2011
    ..b>Inflammatory bowel diseases such as ulcerative colitis and Crohn's disease have been linked to the development of colorectal ..
  45. Study of LY108 innate and adaptive immune responses
    CORNELIS P TERHORST; Fiscal Year: 2013
    ..Ly108 (Slamf6) controls the adaptive and innate immune responses involved in the pathogenesis of Inflammatory Bowel Diseases (IBD)...
  46. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
    ....
  47. OSCCAR: Ocean State Crohn's and Colitis Area Registry
    MARJORIE MERRICK; Fiscal Year: 2012
    DESCRIPTION OF PROJECT: The inflammatory bowel diseases (IBD) are chronic immune-mediated conditions of the gastrointestinal tract that include Crohn's disease and ulcerative colitis, affecting ~1.1 million Americans...
  48. Orphan nuclear receptor Nur77 and intestinal inflammmation
    Dezheng Zhao; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The pathophysiology of inflammatory bowel diseases is largely unknown...
  49. CYTOKINES AND INFLAMMATORY BOWEL DISEASE
    Fabio Cominelli; Fiscal Year: 2009
    ..may play a key role in the pathogenesis of Crohn's disease (CD), one of the known idiopathic inflammatory bowel diseases (IBD)s...
  50. Intestinal Anion Transporters: Function and Regulation
    Pradeep K Dudeja; Fiscal Year: 2013
    ..In fact, local starving of the colon plays a critical role in the etiology of inflammatory bowel diseases. This warrants the need for a better understanding of the regulation of their absorption...
  51. The Roles of IBD Associated Genes ATG16L1 and TNFSF15 in Gut Mucosal Inflammation
    David Q Shih; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) result from complex interactions between susceptibility genes, the environment, and the mucosal immune system...
  52. Intestinal Mucosal Wound Resealing in IBD
    Asma Nusrat; Fiscal Year: 2013
    ..Disruption of the epithelial barrier in inflammatory bowel diseases and ischemia result in fluid &electrolyte loss and exposure of tissues to luminal antigens and ..
  53. The role of ErbB-4 in inflammation-induced colon carcinogenesis
    Mark R Frey; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Inflammatory bowel diseases are associated with increased risk of early-onset colorectal cancer, incurring great cost both economically and in patient morbidity and mortality...
  54. Defining the genetic architecture of IBD in Ashkenazi Jewish populations
    Judy H Cho; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The inflammatory bowel diseases (IBD) are comprised of Crohn's disease and ulcerative colitis and affect approximately 1.4 million Americans. A central feature of IBD epidemiology is the 4.3-7...
  55. Indoleamine 2,3 Dioxygenase in Colitis Associated Cancer
    MATTHEW AARON CIORBA; Fiscal Year: 2013
    ..in laboratory investigation and is fellowship trained in gastroenterology with a focus in the inflammatory bowel diseases. He is currently expanding his scientific skills in investigation of intestinal inflammation, ..
  56. Role of Adaptive Immunity in the Development of Colitis in TLR5 Deficient Mice
    Matam Vijay Kumar; Fiscal Year: 2013
    b>Inflammatory bowel diseases (IBD) Crohn's Disease (CD) and Ulcerative Colitis (UC) are associated with substantial health burden in the United States...
  57. Mechanisms of Mucosal Th17 Cell Induction By Segmented Filamentous Bacteria
    IVAYLO IVANOV IVANOV; Fiscal Year: 2013
    ..g. inflammatory bowel diseases (IBD), diabetes, arthritis...
  58. REGULATION OF IMMUNOSUPPRESSIVE MOLECULES IN IBD
    Christian Jobin; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease represent a major health problem in ..
  59. Epigenetic regulation of intestinal homeostasis
    Theresa Alenghat; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) are multifactorial disorders that represent a significant public health challenge...
  60. HLA and KIR Genomics in Inflammatory Bowel Disease
    Elizabeth A Trachtenberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The two common inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing, remitting conditions of the gastrointestinal tract...
  61. Role of intraepithelial T cells in Toxoplasma gondii-induced inflammatory ileitis
    Eric Y Denkers; Fiscal Year: 2010
    ..Ultimately, this will enable development of rational treatment strategies for inflammatory bowel diseases caused by dysregulated mucosal immunity in humans...
  62. Netrin-1 Regulation of T cell trafficking in chronic intestinal inflammation
    CAROL AHERNE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inflammatory bowel diseases (IBD) are relapsing remitting conditions that manifest as chronic and debilitating inflammation of the intestine in an ever-increasing number of patients in the USA1!"..
  63. Diet and the Calcium Channel TRPV6 in Colon Hyperplasia
    Sara Peleg; Fiscal Year: 2010
    ..The etiologies of inflammatory bowel diseases include genetic background and western life style that impair the microbial flora in the gut, such as ..
  64. BACTERIAL INDUCED COLITIS IN HLA-B27 RATS
    LEVINUS DIELEMAN; Fiscal Year: 2002
    ..Genetic and environmental factors are extremely important in the pathogenesis of the idiopathic chronic inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD)...
  65. Development of a LH-PCR Based Diagnostic for Inflammatory Bowel Disease
    Patrick Gillevet; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Inflammatory Bowel Diseases (IBDs), namely ulcerative colitis (UC) and Crohn's disease (CD), are chronic, lifelong, relapsing illnesses, affecting close to 1 million Americans and ..
  66. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2002
    b>Inflammatory bowel diseases (IBD) are chronic, relapsing and tissue destructive diseases...
  67. Systemic AA Amyloidosis Inhibitors
    ALAN SNOW; Fiscal Year: 2004
    ..disorders and includes patients with rheumatoid arthritis, osteomyelitis, ankylosing spondylitis, inflammatory bowel diseases, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever...
  68. Development of immunoassay to measure a novel TNF-like protein
    Sunghee Kim; Fiscal Year: 2007
    ..Tissue localization of TL1A has been reported in inflammatory bowel diseases and atherosclerotic plaques thus indicating that TL1A might play adversary roles in these diseases...
  69. Importance of CD5 for the function of regulatory T cells
    Subbarao Bondada; Fiscal Year: 2009
    ..and the innate immune system have a definite role in inducing intestinal inflammation, a hallmark of inflammatory bowel diseases (IBD)...
  70. Mast Cell-Mediated Intestinal Permeability
    Katherine Groschwitz; Fiscal Year: 2010
    ..barrier function in the pathogenesis of a variety of Gl disorders, including food allergies and inflammatory bowel diseases. Mast cells are key mediators in immediate hypersensitivity reactions and critical regulators of ..
  71. Spondyloarthritis 2006; The Unmet Needs
    John Reveille; Fiscal Year: 2006
    ..arthritis and/or spondylitis, 4) enteropathic arthritis and/or spondylitis (associated with the inflammatory bowel diseases, ulcerative colitis or Crohn's disease); 5) juvenile Spondyloarthritis and 5) undifferentiated SpA,..
  72. POLYMERIC STRUCTURE OF MUCOUS GLYCOPROTEINS
    Veer Bhavanandan; Fiscal Year: 1993
    ..asthma, chronic bronchitis, cystic fibrosis, peptic ulcers, chronic gastritis, infertility and inflammatory bowel diseases. Mucins are rich in carbohydrate and the strong solvation property of the saccharides is thought to be ..
  73. 2002 Gordon Research Conf. on Intermediate Filaments
    PIERRE COULOMBE; Fiscal Year: 2002
    ..g., skin, oral, and eye blistering diseases; inflammatory bowel diseases; liver disorders), muscle (e.g., cardiomyopathies; muscular dystrophy), neural tissue (e.g...
  74. Non-Invasive Approaches to Assessing Inflammation (RMI)
    RYAN SARTOR; Fiscal Year: 2006
    ..susceptibility of chronic inflammatory disorders, including immune-mediated arthritis, diabetes, inflammatory bowel diseases, systemic lupus erythematosus (SLE), glomerulonephritis, vasculitis, atherosclerosis and asthma, a ..
  75. REGULATION OF IL 12 IN MUCOSAL IMMUNITY AND IBD
    Scott Plevy; Fiscal Year: 1999
    The objective of the proposed study is to understand the immunopathogenesis of the human inflammatory bowel diseases (IBD) by characterizing the regulated expression of interleukin-12 (IL-12)...
  76. INTESTINAL INFLAMMATION ORCHESTRATED BY PATHOGENS
    BETH MC CORMICK; Fiscal Year: 1999
    The active phase of Salmonella-associated gastroenteritis along with more chronic states of inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, is characterized histologically by polymorphonuclear leukocyte (PMN) ..
  77. Gastric and intestinal epithelial progenitor cell GAP
    Jeffrey Gordon; Fiscal Year: 2004
    ..accompanies radio- or chemotherapy, and the loss or disruption of intestinal absorptive function due to inflammatory bowel diseases, or surgical resection...