atrophic gastritis

Summary

Summary: GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.

Top Publications

  1. ncbi Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer
    Hiroshi Ohata
    Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Int J Cancer 109:138-43. 2004
  2. ncbi Importance of atrophic gastritis in diagnostics and prevention of gastric cancer: application of plasma biomarkers
    Pentti Sipponen
    Department of Pathology, Jorvi Hospital, Espoo, Finland
    Scand J Gastroenterol 42:2-10. 2007
  3. ncbi Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease
    Nayoung Kim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi Do, South Korea
    Helicobacter 13:245-55. 2008
  4. pmc Inverse background of Helicobacter pylori antibody and pepsinogen in reflux oesophagitis compared with gastric cancer: analysis of 5732 Japanese subjects
    Y Yamaji
    Division of Gastroenterology, Department of Internal Medicine, University of Tokyo, Tokyo, Japan
    Gut 49:335-40. 2001
  5. ncbi Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening
    M Dinis-Ribeiro
    Showa University, Tokyo, Japan
    J Med Screen 11:141-7. 2004
  6. ncbi Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated
    T Ohkusa
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Ann Intern Med 134:380-6. 2001
  7. ncbi Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis, enterochromaffin-like cell lesions and gastric carcinoids
    M Peracchi
    Gastroenterology Unit, Department of Medical Sciences, University of Milan, Ospedale Maggiore IRCCS, Padiglione Granelli, Via F Sforza 35, 20122 Milan, Italy
    Eur J Endocrinol 152:443-8. 2005
  8. ncbi Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies
    Qin Cao
    Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China
    J Dig Dis 8:15-22. 2007
  9. ncbi Epidemiology of chronic atrophic gastritis: population-based study among 9444 older adults from Germany
    M N Weck
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Aliment Pharmacol Ther 26:879-87. 2007
  10. ncbi The ACE gene polymorphism is associated with the incidence of gastric cancer among H. pylori seropositive subjects with atrophic gastritis
    Yasuyuki Goto
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Asian Pac J Cancer Prev 6:464-7. 2005

Research Grants

  1. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
  2. Oxyntic Atrophy and Novel Gastric Lineages
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
  3. Serum biomarkers for early detection of H. pylori-associated gastric cancer
    Jay V Solnick; Fiscal Year: 2013
  4. GNOTOBIOTIC TRANSGENIC MODELS OF THE GASTRIC ECOSYSTEM
    JEFFREY IVAN GORDON; Fiscal Year: 2010
  5. AGE-RELATED GASTRIC CHANGES AND DRUG ABSORPTION
    Aryeh Hurwitz; Fiscal Year: 1993
  6. CAMPYLOBACTER PYLORIDIS IN GASTRODUODENAL DISEASE
    David Graham; Fiscal Year: 1991
  7. H PYLORI AND GASTRIC PRENEOPLASTIC LESIONS
    Julie Parsonnet; Fiscal Year: 1999
  8. HOST RESPONSE TO HELICOBACTER PYLORI INFECTION
    Pelayo Correa; Fiscal Year: 2000
  9. B12 Absorption, Kinetics and Transcobalamin Genotype
    Joshua Miller; Fiscal Year: 2004
  10. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003

Detail Information

Publications227 found, 100 shown here

  1. ncbi Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer
    Hiroshi Ohata
    Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Int J Cancer 109:138-43. 2004
    ..cohort study to determine the association of Helicobacter pylori infection and the progression of chronic atrophic gastritis (CAG) with gastric cancer...
  2. ncbi Importance of atrophic gastritis in diagnostics and prevention of gastric cancer: application of plasma biomarkers
    Pentti Sipponen
    Department of Pathology, Jorvi Hospital, Espoo, Finland
    Scand J Gastroenterol 42:2-10. 2007
  3. ncbi Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease
    Nayoung Kim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi Do, South Korea
    Helicobacter 13:245-55. 2008
    ..This study was performed to evaluate the prevalence of atrophic gastritis (AG) and intestinal metaplasia (IM) and to identify their risk factors with respect to H...
  4. pmc Inverse background of Helicobacter pylori antibody and pepsinogen in reflux oesophagitis compared with gastric cancer: analysis of 5732 Japanese subjects
    Y Yamaji
    Division of Gastroenterology, Department of Internal Medicine, University of Tokyo, Tokyo, Japan
    Gut 49:335-40. 2001
    ..The relationship between Helicobacter pylori and reflux oesophagitis remains controversial...
  5. ncbi Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening
    M Dinis-Ribeiro
    Showa University, Tokyo, Japan
    J Med Screen 11:141-7. 2004
    ..To assess the validity of the measurement of pepsinogen I and II as a screening test for gastric cancer and pre-malignant lesions, namely low-grade dysplasia, both in the general population and in selected groups of patients...
  6. ncbi Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated
    T Ohkusa
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Ann Intern Med 134:380-6. 2001
    ..Glandular atrophy and intestinal metaplasia are precancerous lesions; whether Helicobacter pylori eradication affects these lesions is controversial...
  7. ncbi Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis, enterochromaffin-like cell lesions and gastric carcinoids
    M Peracchi
    Gastroenterology Unit, Department of Medical Sciences, University of Milan, Ospedale Maggiore IRCCS, Padiglione Granelli, Via F Sforza 35, 20122 Milan, Italy
    Eur J Endocrinol 152:443-8. 2005
    ..As circulating chromogranin A (CgA) levels are a marker of neuroendocrine tumours, we evaluated the clinical usefulness of CgA assay in ABG patients to detect those with carcinoids...
  8. ncbi Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies
    Qin Cao
    Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China
    J Dig Dis 8:15-22. 2007
    Currently the screening and diagnosis of gastric cancer and atrophic gastritis are mainly made by endoscopy and biopsy...
  9. ncbi Epidemiology of chronic atrophic gastritis: population-based study among 9444 older adults from Germany
    M N Weck
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Aliment Pharmacol Ther 26:879-87. 2007
    Epidemiological data on chronic atrophic gastritis from general population samples are sparse in Germany.
  10. ncbi The ACE gene polymorphism is associated with the incidence of gastric cancer among H. pylori seropositive subjects with atrophic gastritis
    Yasuyuki Goto
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Asian Pac J Cancer Prev 6:464-7. 2005
    ..Confirmation of the association between ACE polymorphisms and development of gastric cancer requires much larger studies, and the biological role also needs to be fully elucidated...
  11. ncbi Incidence of chronic atrophic gastritis: systematic review and meta-analysis of follow-up studies
    Mariam Abdullahi Adamu
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, 69115, Heidelberg, Germany
    Eur J Epidemiol 25:439-48. 2010
    Chronic atrophic gastritis (CAG) is an important precursor lesion of intestinal gastric cancer. As it is typically asymptomatic, epidemiological data on the incidence of CAG are sparse...
  12. ncbi Prescreening of a high-risk group for gastric cancer by serologically determined Helicobacter pylori infection and atrophic gastritis
    Shigeto Mizuno
    Department of Medical Pharmaceutics, Kobe Pharmaceutical University, 4 19 1 Motoyama kita, Higashinada ku, Kobe, Japan
    Dig Dis Sci 55:3132-7. 2010
    ..of an effective screening system, focusing on high-risk status such as Helicobacter pylori infection and atrophic gastritis, is desirable...
  13. pmc Response of gastric epithelial progenitors to Helicobacter pylori Isolates obtained from Swedish patients with chronic atrophic gastritis
    Marios Giannakis
    Center for Genome Sciences, Washington University, St Louis, Missouri 63108, USA
    J Biol Chem 284:30383-94. 2009
    ..with gastric adenocarcinoma in some humans, especially those that develop an antecedent condition, chronic atrophic gastritis (ChAG)...
  14. ncbi Endoscopic grading of gastroesophageal flap valve and atrophic gastritis is helpful to predict gastroesophageal reflux
    Gwang Ha Kim
    Department of Internal Medicine, Pusan National Unviersity College of Medicine, Busan, Korea
    J Gastroenterol Hepatol 23:208-14. 2008
    ..b>Atrophic gastritis is inversely associated with reflux esophagitis...
  15. ncbi Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study
    Victor D Pasechnikov
    Department of Therapy, Stavropol Medical Academy, Stavropol, Russia
    Scand J Gastroenterol 40:297-301. 2005
    Helicobacter pylori-associated atrophic gastritis is known to be a significant risk factor for gastric cancer...
  16. ncbi Diagnosis of atrophic gastritis from a serum sample
    Pentti Sipponen
    Helsinki University Central Hospital, Department of Pathology, Espoo, Finland
    Clin Lab 48:505-15. 2002
    ..g. elevated levels of homocysteine) or of peptic ulcer is considerably increased and who can then undergo gastroscopy. It also facilitates the diagnosis of non-atrophic Helicobacter gastritis enabling treatment before endoscopy...
  17. ncbi Serum biomarkers for atrophic gastritis and antibodies against Helicobacter pylori in the elderly: Implications for vitamin B12, folic acid and iron status and response to oral vitamin therapy
    Catharina Lewerin
    Departments of Medicine, Sahlgrenska Academy at the University of Gothenburg, Sweden
    Scand J Gastroenterol 43:1050-6. 2008
    To investigate the prevalence of serological markers for chronic atrophic gastritis (AG) and Helicobacter pylori antibodies (HPAb) in an elderly population, and to examine the interrelationship and significance for cobalamin, folic acid ..
  18. ncbi Serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study
    P Sipponen
    Dept of Pathology, Helsinki District University Central Hospital, Espoo, Finland
    Scand J Gastroenterol 37:785-91. 2002
    ..pylori gastritis only. We investigated whether atrophic gastritis can be diagnosed and typed non-endoscopically if the serum levels of pepsinogen I (S-PGI) and gastrin-17 (S-..
  19. ncbi Non-endoscopic diagnosis of multifocal atrophic gastritis; efficacy of serum gastrin-17, pepsinogens and Helicobacter pylori antibodies
    M Hartleb
    Department of Gastroenterology, Silesian University of Medicine, Katowice, Poland
    Acta Gastroenterol Belg 67:320-6. 2004
    ..While screening the patients with atrophic gastritis by endoscopy is unrealistic, a concept of "serological gastric biopsy" based on measurement of gastric ..
  20. ncbi Association of Helicobacter pylori infection with chronic atrophic gastritis: Meta-analyses according to type of disease definition
    Melanie N Weck
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 123:874-81. 2008
    Helicobacter pylori is a major risk factor for chronic atrophic gastritis (CAG). A large variety of definitions of CAG have been used in epidemiologic studies in the past...
  21. ncbi A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma
    Jose Carlos Machado
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias, S N, 4200 465 Porto, Portugal
    Gastroenterology 125:364-71. 2003
    ..the association between variation of the tumor necrosis factor (TNF)-alpha gene and the risk for chronic atrophic gastritis (CAG) and GC...
  22. ncbi Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis
    M Ito
    Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
    Aliment Pharmacol Ther 16:1449-56. 2002
    ..To investigate the effect of the eradication of Helicobacter pylori on histological gastritis...
  23. ncbi Increased breath nitrous oxide after ingesting nitrate in patients with atrophic gastritis and partial gastrectomy
    Takahiro Mitsui
    Research Center of Health, Physical Fitness and Sports, Nagoya University, Furocho, Chikusaku, Nagoya 464 8601, Japan
    Clin Chim Acta 345:129-33. 2004
    ..and N-nitroso compounds due to gastric bacterial growth are often detected in the stomach of patients with atrophic gastritis and partial gastrectomy...
  24. pmc Atrophic gastritis and the risk of incident colorectal cancer
    Adeyinka O Laiyemo
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD, USA
    Cancer Causes Control 21:163-70. 2010
    ..We prospectively examined the association of atrophic gastritis, a pre-malignant condition for gastric cancer and long-term sequelae common to many exposure factors, and ..
  25. ncbi Cobalamin deficiency due to non-immune atrophic gastritis in elderly patients. A report of 25 cases
    N Henoun Loukili
    Department of Internal Medicine, Diabetes and Metabolic Disorders, Hopitaux Universitaires de Strasbourg, France
    J Nutr Health Aging 9:462. 2005
  26. ncbi Biomarkers in various types of atrophic gastritis and their diagnostic usefulness
    Kazimierz Rembiasz
    Department of Gastroenterology, Academy of Medicine, Institute of Physiology, Krakow, Poland
    Dig Dis Sci 50:474-82. 2005
    b>Atrophic gastritis has been shown to involve either the oxyntic gland area, resulting in hypergastrinemia and hypopepsinogenemia I, the antral gland area, causing hypogastrinemia without change in serum pepsinogen I (diffuse antral ..
  27. ncbi ABO blood type, Lewis and Secretor genotypes, and chronic atrophic gastritis: a cross-sectional study in Japan
    Atsuko Shibata
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA
    Gastric Cancer 6:8-16. 2003
    ..Such host factors as Le and Se genotypes and ABO blood type may affect the establishment of H. Pylori infection and, once infected, the risk of chronic atrophic gastritis.
  28. ncbi Chronic atrophic gastritis and metachronous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma
    Akira Yokoyama
    National Hospital Organization Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
    Alcohol Clin Exp Res 33:898-905. 2009
    ..The risk of metachronous gastric cancer is high in Japanese with esophageal squamous cell carcinoma (SCC), especially in alcoholic men, suggesting a common background underlying the gastric and esophageal cancers...
  29. ncbi Prevalence of subtypes of intestinal metaplasia in the general population and in patients with autoimmune chronic atrophic gastritis
    F Petersson
    Pathology Research Dept, Ryhov Hospital, Jonkoping, Sweden
    Scand J Gastroenterol 37:262-6. 2002
    ..IM can be categorized into three subtypes, where type III is associated with gastric carcinoma of intestinal type...
  30. ncbi Lifestyle factors associated with atrophic gastritis among Helicobacter pylori-seropositive Japanese-Brazilians in São Paulo
    Lucy S Ito
    Japanese Brazilian Health Professional Volunteer Group, Sao Paulo, Brazil
    Int J Clin Oncol 8:362-8. 2003
    ..pylori antibody-seropositive Japanese in Brazil, where gastric cancer mortality was reported to be as high as in Japanese in Japan, and seropositive individuals were still frequently detected...
  31. ncbi Is there a possible relation between atrophic gastritis and premature atherosclerosis?
    Ufuk Kutluana
    Department of Internal Medicine, Dokuz Eylul University Medical School, Izmir, Turkey
    Helicobacter 10:623-9. 2005
    In this study, we have aimed to show the possible relation between atrophic gastritis and premature atherosclerosis via hyperhomocysteinemia.
  32. ncbi Helicobacter pylori infection and high dietary salt independently induce atrophic gastritis and intestinal metaplasia in commercially available outbred Mongolian gerbils
    Ingrid L Bergin
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Dig Dis Sci 48:475-85. 2003
    ..pylori. After 37 weeks, five of five infected animals had atrophic gastritis and intestinal metaplasia...
  33. ncbi Severity of chronic atrophic gastritis and subsequent gastric cancer occurrence: a 10-year prospective cohort study in Japan
    M Inoue
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, 464 8681, Nagoya, Japan
    Cancer Lett 161:105-12. 2000
    Chronic atrophic gastritis is regarded as a predisposing factor for gastric cancer associated with Helicobacter pylori infection, and its severity is suggested to be a key influence on gastric cancer risk...
  34. ncbi The 13carbon urea breath test for the diagnosis of Helicobacter pylori infection in subjects with atrophic gastritis: evaluation in a primary care setting
    A Korstanje
    Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 24:643-50. 2006
    ..13)Carbon urea breath testing is reliable to detect current infection with Helicobacter pylori but has been reported to be of limited value in selected patients with atrophic body gastritis or acid-lowering medication...
  35. ncbi Expression of growth hormone and its receptor in chronic atrophic gastritis and its clinical significance
    Jian min Si
    Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou 310016, Zhejiang Province, China
    World J Gastroenterol 10:2908-10. 2004
    To investigate the growth hormone (GH) and growth hormone receptor (GHR) expression of and its clinical significance in patients with chronic atrophic gastritis (CAG).
  36. ncbi Validation of diagnostic tests for Helicobacter pylori with regard to grade of atrophic gastritis and/or intestinal metaplasia
    Cheol Min Shin
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Helicobacter 14:512-9. 2009
    To evaluate the validity of the biopsy-based tests (histology, culture, and urease test) and serology in detecting current Helicobacter pylori infection against a background of atrophic gastritis (AG) or intestinal metaplasia (IM).
  37. ncbi The effect of Helicobacter pylori eradication on the natural course of atrophic gastritis with dysplasia
    A Kokkola
    Second Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Aliment Pharmacol Ther 16:515-20. 2002
    There are few data on the natural course of Helicobacter pylori-related atrophic gastritis.
  38. pmc Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia
    Zhong Wu Li
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, China
    World J Gastroenterol 16:1788-94. 2010
    ..pylori) infection, on the risk of developing severe chronic atrophic gastritis (SCAG) and intestinal metaplasia (IM).
  39. ncbi Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer risk?
    Kanji Kodama
    Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Japan
    Eur J Gastroenterol Hepatol 15:987-93. 2003
    ..Therefore, susceptibility to gastric cancer in H. pylori-infected patients may be derived from increased N-nitroso compounds in gastric juice. However, most H. pylori-infected patients do not develop gastric cancer...
  40. ncbi The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis
    Lisette G Capelle
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Gastrointest Endosc 71:1150-8. 2010
    The OLGA (operative link on gastritis assessment) staging system is based on severity of atrophic gastritis (AG)...
  41. ncbi Remission of severe anemia persisting for over 20 years after eradication of Helicobacter pylori in cases of Ménètrier's disease and atrophic gastritis: Helicobacter pylori as a pathogenic factor in iron-deficiency anemia
    Makoto Yoshimura
    Yoshimura Medical Clinic, Fukui
    Intern Med 42:971-7. 2003
    ..pylori-positive atrophic gastritis case with a 24-year history of iron-deficiency anemia of unknown etiology, and again, complete remission was ..
  42. ncbi Reassessment of intrinsic factor and parietal cell autoantibodies in atrophic gastritis with respect to cobalamin deficiency
    Edith Lahner
    Department of Digestive and Liver Disease, 2nd Medical School, University Sapienza, Rome 00189, Italy
    Am J Gastroenterol 104:2071-9. 2009
    ..Recent studies on IFA and PCA frequency with respect to cobalamin deficiency in biopsy-proven ABG patients are lacking. We addressed this issue using new enzyme-linked immunosorbent assay (ELISA)-based assays...
  43. ncbi Long-term Helicobacter pylori infection in Japanese monkeys induces atrophic gastritis and accumulation of mutations in the p53 tumor suppressor gene
    Touta Oda
    Second Department of Internal Medicine, Oita Medical University, Hasama machi, Japan
    Helicobacter 7:143-51. 2002
    ..To obtain direct evidence of carcinogenesis associated with H. pylori infection, we investigated whether p53 gene mutations are present in the gastric mucosa of a nonhuman primate model susceptible to H. pylori...
  44. ncbi Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men
    Akira Yokoyama
    National Hospital Organization Kurihama Alcoholism Center, Kanagawa, Japan
    J Gastroenterol Hepatol 22:210-7. 2007
    ..Whether alcoholism affects Helicobacter pylori-induced chronic atrophic gastritis (CAG) is unknown.
  45. ncbi Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats
    Wei Li Liu
    Department of Gastroenterology and Zhejiang Key laboratory of Traditional Chinese Medicine TCM, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310012, China
    Acta Pharmacol Sin 28:1001-6. 2007
    To investigate the effect of geranylgeranylacetone (GGA) on the progression of atrophic gastritis in rats and its potential mechanism.
  46. ncbi Atrophic gastritis, Helicobacter pylori, and colorectal cancer risk: a case-control study
    Ai Machida-Montani
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Helicobacter 12:328-32. 2007
    Helicobacter pylori is a major risk factor for atrophic gastritis and gastric cancer. Various extragastric manifestations of H. pylori infection have also recently been suggested. However, the correlation between H...
  47. ncbi Increased risk of developing atrophic gastritis in patients infected with CagA+ Helicobacter pylori
    N Sande
    Dept. of Clinical Chemistry, Helsinki University Central Hospital, Finland
    Scand J Gastroenterol 36:928-33. 2001
    ..To clarify the possible role of CagA positive (CagA+) Helicobacter pylori strains in the development of atrophic gastritis, the prevalence of antibodies to H...
  48. ncbi Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese
    Takehiro Torisu
    Division of General Internal Medicine, Kyushu Dental College, Japan
    J Atheroscler Thromb 16:691-7. 2009
    ..The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects...
  49. ncbi Broccoli consumption and chronic atrophic gastritis among Japanese males: an epidemiological investigation
    Kyoko Sato
    Department of Hygiene and Preventive Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Acta Med Okayama 58:127-33. 2004
    ..This suggests that broccoli consumption prevents chronic atrophic gastritis (CAG) introduced by H. pylori infection and, therefore, gastric cancer...
  50. pmc Age-dependent accuracy of Helicobacter pylori antibody assays for adults, with special emphasis on atrophic gastritis
    A Salomaa-Rasanen
    Department of Bacteriology and Immunology, Haartman Institute, PO Box 21 Haartmaninkatu 3, FIN 00014 University of Helsinki, Helsinki, Finland
    Clin Diagn Lab Immunol 11:1185-8. 2004
    ..The exclusion of false-positive results for patients with atrophic gastritis improved the specificity to 93 to 97% for the older age groups.
  51. ncbi Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 45:428-34. 2009
    ..We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study.
  52. pmc Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells
    Marios Giannakis
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 105:4358-63. 2008
    ..pylori to a rarely captured event in the evolution of its impact on host biology-the transition from chronic atrophic gastritis (ChAG) to gastric adenocarcinoma-and defined the impact of these adaptations on an intriguing but poorly ..
  53. ncbi Serum vitamin B12 concentrations and atrophic gastritis in older New Zealanders
    T J Green
    Department of Human Nutrition, University of Otago, Dunedin, New Zealand
    Eur J Clin Nutr 59:205-10. 2005
    To determine the serum vitamin B(12) status of older New Zealanders and to assess the impact of atrophic gastritis on vitamin B(12) status.
  54. ncbi Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Epidemiol 39:129-34. 2010
    ..We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany.
  55. ncbi In diffuse atrophic gastritis, routine histology underestimates Helicobacter pylori infection
    Pier Alberto Testoni
    Division of Gastroenterology and Gastrointestinal Endoscopy, University Vita Salute San Raffaele, IRCCS San Raffaele Hospital, Milano, Italy
    J Clin Gastroenterol 35:234-9. 2002
    ..However, when atrophy occurs, the sensitivity of bacterial detection varies. This study assessed the routine histologic sensitivity for current infection in patients with atrophic gastritis, with and without intestinal metaplasia.
  56. ncbi Progression of atrophic gastritis and intestinal metaplasia drives Helicobacter pylori out of the gastric mucosa
    Hae Yeon Kang
    Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Dig Dis Sci 51:2310-5. 2006
    ..negative, and to find out the specific disease category that is more affected by the hostile relationship of atrophic gastritis and intestinal metaplasia (IM) with H. pylori...
  57. ncbi Detection rate of Helicobacter pylori against a background of atrophic gastritis and/or intestinal metaplasia
    Ji Youn Yoo
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi Do, South Korea
    J Clin Gastroenterol 41:751-5. 2007
    To evaluate the detection rate of the CLOtest, Giemsa stain, and culture for the diagnosis of Helicobacter pylori organisms in patients with or without atrophic gastritis (AG) and/or intestinal metaplasia (IM).
  58. ncbi Helicobacter pylori infection and chronic atrophic gastritis: associations according to severity of disease
    Melanie N Weck
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Epidemiology 20:569-74. 2009
    Helicobacter pylori infection is an established risk factor for chronic atrophic gastritis. However, estimates of the strength of this association have varied widely, possibly due to clearance of the infection in severe stages of chronic ..
  59. ncbi Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis
    Nuria Alonso
    Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol, Ctra Canyet s n, Badalona 08916, Barcelona, Spain
    Eur J Endocrinol 157:763-9. 2007
    ..DM1) show increased prevalence of pernicious anaemia, the histological substrate of which is type A chronic atrophic gastritis (CAG) in the stomach corpus, the main source of ghrelin...
  60. ncbi Analysis of whole genomic expression profiles of Helicobacter pylori related chronic atrophic gastritis with IL-1B-31CC/-511TT genotypes
    Shao Ying Wang
    Institute of Digestive Disease, Tongji Hospital, Tongji University, Shanghai, China
    J Dig Dis 10:99-106. 2009
    ..The current study evaluated the characterization of whole genomic expression profiles of the premalignant condition: H. pylori-related chronic atrophic gastritis (CAG) with IL-1B-31CC/-511TT genotypes.
  61. ncbi Serum biomarkers provide an accurate method for diagnosis of atrophic gastritis in a general population: The Kalixanda study
    Tom Storskrubb
    Centre for Family and Community Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 43:1448-55. 2008
    Serological biomarkers can be used for non-invasive diagnosis of gastritis and atrophic gastritis. The aim of this study was to compare the validity of serum levels of pepsinogen I (PGI) and II (PGII), gastrin-17 (G-17) and Helicobacter ..
  62. ncbi Clinical research on acupuncture and moxibustion treatment of chronic atrophic gastritis
    Xiyan Gao
    Department of Acupuncture and Moxibustion, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China
    J Tradit Chin Med 27:87-91. 2007
    To observe the clinical therapeutic effects of acupuncture and moxibustion in treating chronic atrophic gastritis.
  63. ncbi Lymph node metastasis from gastric carcinoid tumors occurring concomitantly with gastric adenocarcinomas and atrophic gastritis
    Rocco Roberto Pidoto
    Chirurgie Digestive Endocrinienne et Thoracique, centre hospitalier régional d Orléans, 14 avenue de l Hôpital, 45 067 Orleans Cedex 2, France
    J Gastrointest Surg 10:402-6. 2006
    ..a case of gastric carcinoids concomitant with gastric adenocarcinoma in a 50-year-old woman affected by atrophic gastritis. Number and size of the lesions, pathological examinations, and underlying gastric disease all indicated low-..
  64. ncbi Muscovite reverses gastric gland atrophy and intestinal metaplasia by promoting cell proliferation in rats with atrophic gastritis
    Liang jing Wang
    Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, PR China
    Digestion 79:79-91. 2009
    To detect whether muscovite exerts its protective role in the progression of atrophic gastritis (AG) and evaluate the possible mechanism.
  65. ncbi Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis
    Junichi Kawashima
    Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda Tsujido Machi, Kawagoe, Saitama 350 8550, Japan
    J Gastroenterol 44:1046-54. 2009
    ..We attempted to clarify the significance of atrophic change of gastric mucosa for reduction of plasma ghrelin concentration irrespective of Helicobacter pylori (Hp) infection...
  66. ncbi H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPAR gamma and impaired apoptosis in gastric carcinogenesis
    Peter C Konturek
    1st Department of Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Med Sci Monit 9:SR53-66. 2003
    ..Factors emanating from bacterium as well as from environmental contributions such as salt diet and inadequate supply of antioxidants, affect the risk for GC development...
  67. ncbi Evaluation of epstein-barr virus DNA load in gastric mucosa with chronic atrophic gastritis using a real-time quantitative PCR assay
    Atsuyoshi Hirano
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Yamaguchi 755 8505, Japan
    Int J Gastrointest Cancer 34:87-94. 2003
    ..However, the frequency and distribution of EBV infection in the gastric mucosa of chronic atrophic gastritis (CAG) are still unclear. To clarify these points, we evaluated the EBV DNA load in gastric mucosa with CAG.
  68. ncbi Serum pepsinogens as a predicator of the topography of intestinal metaplasia in patients with atrophic gastritis
    Yoshihisa Urita
    Department of Gastroenterology and Hepatology, Toho University School of Medicine, Tokyo, Japan
    Dig Dis Sci 49:795-801. 2004
    The importance of atrophic gastritis with intestinal metaplasia is related to the fact that it increases the risk of gastric cancer development...
  69. ncbi The long-term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundic atrophic gastritis
    T Kamada
    Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan
    Aliment Pharmacol Ther 18:245-52. 2003
    To investigate whether curing Helicobacter pylori infection improves symptoms over the long-term in Japanese patients with nonulcer dyspepsia and fundic atrophic gastritis.
  70. ncbi Association between gastroesophageal flap valve, reflux esophagitis, Barrett's epithelium, and atrophic gastritis assessed by endoscopy in Japanese patients
    Yasuhiro Fujiwara
    Department of Gastroenterology, Osaka City University, Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 38:533-9. 2003
    ..b>Atrophic gastritis is often found in Japanese patients and is inversely related to reflux esophagitis...
  71. ncbi Plasma obestatin levels in men with chronic atrophic gastritis
    Xin Yuan Gao
    Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, China
    Peptides 29:1749-54. 2008
    ..of the present study was to investigate the modification of plasma obestatin levels in men with chronic atrophic gastritis. Men older than 65 years undergoing upper gastrointestinal endoscopy were included...
  72. ncbi Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression?
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
    Eur J Cancer 45:2860-6. 2009
    Helicobacter pylori infection is a key risk factor for chronic atrophic gastritis (CAG), an established precursor of gastric cancer. There is increasing evidence of frequent clearance of the infection during progression of CAG...
  73. ncbi Protective action of acupuncture and moxibustion on gastric mucosa in model rats with chronic atrophic gastritis
    Xiyan Gao
    Department of Acupuncture and Massage, Henan College of TCM, Zhengzhou, Henan, China
    J Tradit Chin Med 25:66-9. 2005
    To probe the mechanism of acupuncture and moxibustion in atrophic gastritis so as to provide a basis for clinical treatment.
  74. ncbi Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans
    Hae Wan Lee
    Department of Surgery, Hallym University Sacred Heart Hospital, Anyang, Korea
    J Dig Dis 10:265-71. 2009
    ..Since whether a patient remains with chronic superficial gastritis (CSG) or progresses to either chronic atrophic gastritis (CAG) or gastric carcinoma (GC) could be a genetic predisposition unique in each population, we hypothesized ..
  75. ncbi Chronic atrophic gastritis and Helicobacter pylori infection among Japanese Americans in Seattle
    T Namekata
    Pacific Rim Disease Prevention Center, Seattle, WA 98144, USA
    Am J Epidemiol 151:820-30. 2000
    ..type of gastric cancer is intestinal type carcinoma, which usually occurs in stomachs containing chronic atrophic gastritis. Individuals with chronic atrophic gastritis are considered to be at increased risk for developing ..
  76. ncbi Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects
    D Z van Asselt
    Department of Geriatric Medicine, University Hospital Nijmegen, The Netherlands
    Am J Clin Nutr 68:328-34. 1998
    ..The reason for the high prevalence of mild cobalamin (vitamin B-12) deficiency in the elderly is poorly understood...
  77. ncbi Plasma acylated ghrelin levels are higher in patients with chronic atrophic gastritis
    Davide Campana
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Clin Endocrinol (Oxf) 67:761-6. 2007
    ..For this reason we decided to investigate the modification of the circulating levels not only of total but also of acylated ghrelin in a series of patients with chronic atrophic gastritis.
  78. ncbi Combined adenocarcinoma and carcinoid tumor in atrophic gastritis
    Debasis Adhikari
    Pathology Department, North Shore University Hospital and NYU School of Medicine, Manhasset, New York 11030, USA
    Ann Clin Lab Sci 32:422-7. 2002
    The development of adenocarcinoma or carcinoid tumors in atrophic gastritis is widely documented...
  79. pmc Morphological and pathologic changes of experimental chronic atrophic gastritis (CAG) and the regulating mechanism of protein expression in rats
    Liang jing Wang
    Department of Gastroenterology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    J Zhejiang Univ Sci B 7:634-40. 2006
    To study the pathologic change and molecular regulation in cell proliferation and apoptosis of gastric mucosa in rats with chronic atrophic gastritis (CAG), and evaluate the possible mechanisms.
  80. ncbi Helicobacter pylori may be involved in cognitive impairment and dementia development through induction of atrophic gastritis, vitamin B-12 folate deficiency, and hyperhomocysteinemia sequence
    Jannis Kountouras
    Am J Clin Nutr 86:805-6; author reply 806-7. 2007
  81. ncbi Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression
    A Shiotani
    Health Administration Center, Wakayama University, Wakayama, Japan
    Aliment Pharmacol Ther 24:71-80. 2006
    ..Aberrant expression of CDX has also been shown to correlate with the development of intestinal metaplasia...
  82. ncbi Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:2782-6. 2007
    Chronic atrophic gastritis (CAG), a precursor of intestinal gastric cancer, is mostly ascertained noninvasively by serum pepsinogens in epidemiologic studies. However, serological definitions vary widely...
  83. pmc Helicobacter pylori-associated chronic atrophic gastritis involving the gastric body and severe disease by Vibrio cholerae
    Raul Leon-Barua
    The Alexander von Humboldt Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Calle Honorio Delgado 430, San Martin de Porres, Lima 31, Peru
    Trans R Soc Trop Med Hyg 100:567-72. 2006
    ..Furthermore, cases had significantly more chronic atrophic gastritis (45.7% vs. 12.5%; P=0.002) and intestinal metaplasia (37.1% vs. 2.5%; P<0...
  84. ncbi Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer
    Akiko Shiotani
    Health Administration Center, Wakayama University, Japan
    Am J Gastroenterol 100:581-7. 2005
    ..The absence of sonic hedgehog (Shh) correlates with the development of intestinal metaplasia (IM) suggesting the possibility of an association between Shh expression and neoplastic transformation...
  85. ncbi Atrophic gastritis: deficient complex I of the respiratory chain in the mitochondria of corpus mucosal cells
    Marju Gruno
    Department of Pathophysiology, Centre of Molecular and Clinical Medicine, Faculty of Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia
    J Gastroenterol 43:780-8. 2008
    ..However, it is not known whether oxidative energy metabolism has already become altered in conditions of atrophic gastritis, a precancerous state of gastric disease...
  86. ncbi A negative Helicobacter pylori serology test is more reliable for exclusion of premalignant gastric conditions than a negative test for current H. pylori infection: a report on histology and H. pylori detection in the general adult population
    Tom Storskrubb
    Centre for Family Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 40:302-11. 2005
    ..pylori infection and associated gastric mucosal findings by means of histological survey of a random adult population...
  87. ncbi Agreement of endoscopic findings and serum pepsinogen levels as an indicator of atrophic gastritis
    M Inoue
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 7:261-3. 1998
    Serum pepsinogen I and II levels have recently become popular as indicators of atrophic gastritis in epidemiological studies...
  88. ncbi Interactions between gastric epithelial stem cells and Helicobacter pylori in the setting of chronic atrophic gastritis
    Jung D Oh
    Center for Genome Sciences and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63108, USA
    Curr Opin Microbiol 9:21-7. 2006
    Chronic atrophic gastritis (ChAG), a Helicobacter pylori-associated risk factor for the development of gastric cancer, involves loss of acid-producing parietal cells...
  89. pmc The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression
    Jung D Oh
    Center for Genome Sciences, Washington University School of Medicine, 4444 Forest Park, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 103:9999-10004. 2006
    ..However, a subset of individuals develops chronic atrophic gastritis (ChAG), a condition characterized in part by diminished numbers of acid-producing parietal cells and ..
  90. pmc Intracellular Helicobacter pylori in gastric epithelial progenitors
    Jung D Oh
    Center for Genome Sciences and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 102:5186-91. 2005
    ..pylori clinical isolates in a gnotobiotic transgenic mouse model of human chronic atrophic gastritis, a preneoplastic condition...
  91. ncbi Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus-evaluation of 24-h pH monitoring
    K Haruma
    Gastrointestinal Unit, First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
    Aliment Pharmacol Ther 13:155-62. 1999
    ..The aim of this study was to evaluate the effect of eradication of H. pylori in a 24-h study of gastric acidity in patients with atrophic gastritis of the corpus.
  92. ncbi Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions
    Xin Pu Miao
    Department of Gastroenterology, West China Hospital of Sichuan University, 17 Renmin Avenue, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 13:2867-71. 2007
    ..To investigate the expression of ornithine decarboxylase (ODC) in precancerous and cancerous gastric lesions...
  93. ncbi Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Gastroenterology 123:92-105. 2002
    ..This study aimed to examine effects of these polymorphisms on gastric acid secretion, atrophic gastritis, and risk of peptic ulcer in Japan.
  94. ncbi Ten-year prospective follow-up study on the relationship between Helicobacter pylori infection and progression of atrophic gastritis, particularly assessed by endoscopic findings
    N Sakaki
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo, Japan
    Aliment Pharmacol Ther 16:198-203. 2002
    To ascertain the progression of atrophic gastritis due to Helicobacter pylori infection, we conducted a 10-year prospective follow-up study with annual endoscopy of the stomach.
  95. ncbi Atrophic gastritis as a cause of hyperhomocysteinaemia
    L Santarelli
    Department of Internal Medicine, Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy
    Aliment Pharmacol Ther 19:107-11. 2004
    ..It is often related to low levels of vitamin B12 and/or folate, enzymatic co-factors of methionine metabolism. Atrophic gastritis, often caused by Helicobacter pylori infection, may impair vitamin absorption.
  96. ncbi Prevalence of low vitamin B12 and high homocysteine in serum in an elderly male population: association with atrophic gastritis and Helicobacter pylori infection
    P Sipponen
    Dept of Pathology, Helsinki University District Central Hospital, Jorvi Hospital, Espoo, Finland
    Scand J Gastroenterol 38:1209-16. 2003
    ..We examined how common an undiagnosed vitamin B12 deficiency is among elderly men in the general population and, in particular, how often this deficiency is related to atrophic corpus gastritis...
  97. ncbi Multifocal atrophic gastritis and gastric carcinoma
    E Isaac Faraji
    Division of Gastroenterology and Hepatology, MCP Hahnemann University School of Medicine, Mail Stop 913, 219 Broad Street, 5th Floor, Philadelphia, PA 19107, USA
    Gastroenterol Clin North Am 31:499-516. 2002
    ..Others, who acquired the H. pylori infection in early childhood, develop progressive multifocal atrophic gastritis with loss of gastric glands...
  98. ncbi Composite gastric carcinoma and precursor lesions with amphicrine features in chronic atrophic gastritis
    G Pasquinelli
    Institute of Clinical Electron Microscopy, Policlinico S Orsola, Bologna, Italy
    Ultrastruct Pathol 17:9-24. 1993
    ..The tumor was associated with hypergastrinemia related to chronic atrophic gastritis (achlorhydria) and with multiple proliferative lesions, such as intramucosal microcarcinoid (IMC) and ..
  99. ncbi Oesophageal adenocarcinoma or gastric cancer with or without eradication of Helicobacter pylori infection in chronic atrophic gastritis patients: a hypothetical opinion from a systematic review
    S Nakajima
    Department of Medicine Gastroenterology Section, Social Insurance Shiga Hospital, Shiga, Japan
    Aliment Pharmacol Ther 20:54-61. 2004
    As chronic atrophic gastritis is a precancerous condition for gastric cancer and the eradication of Helicobacter pylori infection halts chronic gastritis, eradication of infection may prevent gastric cancer...
  100. ncbi [Long-term follow-up of H. pylori infection--from gastritis to gastric cancer]
    Masahiro Asaka
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 63:185-90. 2005
  101. ncbi Morpho-functional comparisons in Helicobacter pylori-associated chronic atrophic gastritis
    V D Pasechnikov
    Department of Therapy, Medical Academy, Stavropol, Russian Federation
    Rocz Akad Med Bialymst 50:183-7. 2005
    ..pylori)-associated chronic atrophic gastritis, with reference to endoscopical Kimura-Takemoto's staging, chromoendoscopical and histological features.

Research Grants42

  1. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
    ..Helicobacter pylori induces superficial gastritis and transient hypochlorhydria which may progress to atrophic gastritis and eventually gastric adenocarcinoma...
  2. Oxyntic Atrophy and Novel Gastric Lineages
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
    ..The vast majority of gastric cancer evolves in the stomach in the setting of chronic atrophic gastritis usually in association with Helicobacter pylori infection. While the role of H...
  3. Serum biomarkers for early detection of H. pylori-associated gastric cancer
    Jay V Solnick; Fiscal Year: 2013
    ..type, which follows a temporal sequence of pathologic changes that leads from chronic non-atrophic gastritis, to atrophic gastritis, intestinal metaplasia, dysplasia, and finally gastric adenocarcinoma...
  4. GNOTOBIOTIC TRANSGENIC MODELS OF THE GASTRIC ECOSYSTEM
    JEFFREY IVAN GORDON; Fiscal Year: 2010
    ..A subset of Hp-infected hosts develops chronic atrophic gastritis (ChAG), characterized in part by loss of acid-producing parietal cells (PCs)...
  5. AGE-RELATED GASTRIC CHANGES AND DRUG ABSORPTION
    Aryeh Hurwitz; Fiscal Year: 1993
    ..Serum pepsinogen and gastrin levels will be used as indicators of atrophic gastritis, and inability to secrete acid...
  6. CAMPYLOBACTER PYLORIDIS IN GASTRODUODENAL DISEASE
    David Graham; Fiscal Year: 1991
    ..pyloridis to development of chronic atrophic gastritis; 6) the relationship between C...
  7. H PYLORI AND GASTRIC PRENEOPLASTIC LESIONS
    Julie Parsonnet; Fiscal Year: 1999
    ..highest incidence in developing countries, is preceded by a sequence of histologic changes including chronic atrophic gastritis (CAG), intestinal metaplasia (IM), and dysplasia...
  8. HOST RESPONSE TO HELICOBACTER PYLORI INFECTION
    Pelayo Correa; Fiscal Year: 2000
    ..b) In New Orleans, subjects diagnosed with multiphocal atrophic gastritis (MAG), a cancer precursor lesion, will be compared with subjects with non-atrophic gastritis (diffuse antral ..
  9. B12 Absorption, Kinetics and Transcobalamin Genotype
    Joshua Miller; Fiscal Year: 2004
    ..The primary cause of B12 deficiency is malabsorption due to pernicious anemia and atrophic gastritis. In preliminary studies, circumstantial evidence has been obtained suggesting that a common polymorphism (..
  10. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
    ..data supports this bacterium as a cofactor because it causes chronic gastritis which may progress to atrophic gastritis, a precursor lesion for intestinal type gastric cancer...
  11. Association between periodontal disease and gastric precancerous lesions
    Yu Chen; Fiscal Year: 2009
    ..A continuum of progression from chronic superficial gastritis through atrophic gastritis, intestinal metaplasia, ultimately leading to dysplasia, has been proposed for the intestinal type of ..
  12. PATHOGENESIS OF H PYLORI INDUCED GASTRIC INFLAMMATION
    Richard Peek; Fiscal Year: 2000
    ..The chronic inflammatory process associated with the infection has also been linked to atrophic gastritis, gastric adenocarcinoma and non-Hodgkins lymphoma of the stomach...
  13. TOPICAL DRUG DELIVERY FOR GASTRIC H. PYLORI INFECTION
    Catherine Woods; Fiscal Year: 2000
    ..pylori infections, atrophic gastritis and gastric cancer...
  14. A Novel Diagnostic Test To Detect Vitamin B12 Deficiency
    David Wagner; Fiscal Year: 2007
    ..are at risk for preclinical vitamin B12 deficiency due to the increased presence of B12 malabsorption and atrophic gastritis as a consequence of aging...
  15. Altering Gastric Epithelial Cell Differentiation
    Juanita Merchant; Fiscal Year: 2007
    ..Chronic gastritis also results in initial increase then loss of parietal cells over time (chronic atrophic gastritis)...
  16. HB-EGF's Role in Atrophic Gastritis and Gastric Cancer
    Theodore Koh; Fiscal Year: 2002
    ..2. Determine the role of HB-EGF expression in gastric parietal cells on gastric mucosal differentiation by creating transgenic mice that over-expression HB-EGF in parietal cells. ..
  17. INTESTINAL METAPLASIA, ASCORBATE, AND H PYLORI
    Julie Parsonnet; Fiscal Year: 1993
    ..Two preneoplastic lesions appear to be addressable: atrophic gastritis and intestinal metaplasia. In the future, we hope to evaluate the effects of anti-H...
  18. H PYLORI RELATIONSHIP TO DIGESTIVE DISEASES AND CANCER
    Richard Peek; Fiscal Year: 2001
    ..pylori infection is an important etiologic factor for the development of atrophic gastritis and gastric adenocarcinoma; however, only a small percentage of infected persons develop neoplasia...
  19. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  20. CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIA
    Chaim Hershko; Fiscal Year: 2001
    ..abstract_text> ..
  21. HELICOBACTER INFECTION AND GROWTH OF CHILDREN
    Pelayo Correa; Fiscal Year: 2001
    ..pylori infection and growth retardation, essential information for evaluating the effects of H. pylori infection on children's health and targeting appropriate preventive strategies. ..
  22. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..Clinical and epidemiologic studies suggest that the development of atrophic gastritis intestinal metaplasia and dysplasia represent essential steps in the cascade of events leading to gastric ..
  23. The Role of Adenosine Receptors in Th Cell Development and Function
    Peter Ernst; Fiscal Year: 2008
    ..abstract_text> ..
  24. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  25. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  26. Education Program for Digestive Health Research
    Peter Ernst; Fiscal Year: 2008
    ..The trainees will be exposed to an enjoyable experience and long-term personal contacts that will be influential in encouraging them to pursue a career in biomedical research that will improve digestive health. ..
  27. H.pylori Effects on DNA Repair in Gastric Epithelium
    Antonia Sepulveda; Fiscal Year: 2008
    ..Knowledge gained from this study is likely to support the indication for Hp eradication in H. pylori-infected patients to prevent GC. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  28. Molecular strategies to define carcinoids and rationalize surgical intervention
    Irvin Modlin; Fiscal Year: 2009
    ..This will provide novel biological information and provide molecular data to identify occult metastasis predict spread and facilitate preemptive appropriate therapy. ..
  29. The Novel Role for Adenosine Receptor Agonists in Acquired Neonatal Tolerance
    Peter Ernst; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. Effects of Ginseng and Ginkgo on Drug Disposition in Man
    Aryeh Hurwitz; Fiscal Year: 2003
    ..Interactions of chronic ginseng and ginkgo with drug-metabolizing pathways and with cognitive function will thus be determined. ..
  31. Mutation and Environmental Exposures
    JAY HUNT; Fiscal Year: 2003
    ..Scott Cancer Center at LSUHSC-New Orleans. ..
  32. Molecular Epidemiology and Gene-Environment Interaction
    Zuo Feng Zhang; Fiscal Year: 2004
    ..abstract_text> ..
  33. Surrogate Biomarkers of Micrometastatic Gastric Cancer
    Adam Smolka; Fiscal Year: 2004
    ..The successful development and validation of a lymph node RT-PCR-based assay for micrometastatic stomach cancer is likely to have a significant clinical impact. ..
  34. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  35. The pathobiology of gastrointestinal disease in mice
    Peter Ernst; Fiscal Year: 2005
    ....
  36. Role of Infectious Agents in Pediatric Crohn's Disease
    Benjamin Gold; Fiscal Year: 2005
    ..Subsequent prospective application of methods and systems developed by this proposal to the uniquely large, well characterized Consortium cohort will optimize detecting differences between CD and non-disease...
  37. Molecular Strategies for Gastric Carcinoid Surgery
    Irvin Modlin; Fiscal Year: 2005
    ..A pre-operative determination of the neoplastic ECL cell gene expression relating to gastrin responsiveness will improve the rationale for therapeutic gastric or antral resection. ..
  38. Risk factors for gastric disease in pediatric H. pylori
    Benjamin Gold; Fiscal Year: 2006
    ..Sydney system, we demonstrated a histopathologic spectrum in children, which included novel observations of atrophic gastritis with intestinal metaplasia...
  39. Cytokine Responses to H. pylori Infection, Immunization
    Peter Ernst; Fiscal Year: 2006
    ..pylori infection. 2). Identify T cell markers that are correlates of immunity. 3). Define mechanisms of host defense attributed to "protective" Th cells. ..
  40. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  41. Mechanisms of H pylori-Induced Hypochlorhydria
    Adam Smolka; Fiscal Year: 2008
    ..In a significant subset of patients, the ensuing gastritis progresses to atrophic gastritis, intestinal metaplasia, dysplasia, and eventually gastric adenocarcinoma...