enterocolitis

Summary

Summary: Inflammation of the MUCOSA of both the SMALL INTESTINE and the LARGE INTESTINE. Etiology includes ISCHEMIA, infections, allergic, and immune responses.

Top Publications

  1. ncbi Enterocolitis complicating Hirschsprung's disease
    Daniela Vieten
    Department of Paediatric Surgery, Directorate of Children s Services, Bristol Royal Hospital for Children, Paul O Gorman Building, Upper Maudlin Street, Bristol BS2 8BJ, UK
    Semin Pediatr Surg 13:263-72. 2004
  2. pmc Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
    Kimberly E Beck
    Surgery Branch and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1201, USA
    J Clin Oncol 24:2283-9. 2006
  3. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
  4. pmc Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10-/- mice via Toll-like-receptor-2 and -4 signaling
    Lea Maxie Haag
    Department of Microbiology and Hygiene, Charite University Medicine Berlin, Berlin, Germany
    PLoS ONE 7:e40761. 2012
  5. ncbi A multicentre retrospective study of 66 Italian children with food protein-induced enterocolitis syndrome: different management for different phenotypes
    S Miceli Sopo
    Department of Pediatrics, University of Sacred Heart Agostino Gemelli Rome, Rome, Italy
    Clin Exp Allergy 42:1257-65. 2012
  6. ncbi The prevalence and natural course of food protein-induced enterocolitis syndrome to cow's milk: a large-scale, prospective population-based study
    Yitzhak Katz
    Allergy and Immunology Institute, Assaf Harofeh Medical Center, Zerifin, Israel
    J Allergy Clin Immunol 127:647-53.e1-3. 2011
  7. ncbi A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents
    Stefan H Oehlers
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    Dev Dyn 240:288-98. 2011
  8. ncbi Rice protein-induced enterocolitis syndrome
    Iva Hojsak
    Referral Center for Pediatric Gastroenterology and Nutrition, Zagreb Children s Hospital, Klaiceva 16, HR 10000 Zagreb, Croatia
    Clin Nutr 25:533-6. 2006
  9. ncbi Food protein-induced enterocolitis syndrome, from practice to theory
    Stefano Miceli Sopo
    Department of Paediatrics, Catholic University of Sacred Heart, L go Gemelli 8, Rome 00168, Italy
    Expert Rev Clin Immunol 9:707-15. 2013
  10. ncbi Food protein-induced enterocolitis syndrome: 16-year experience
    Sam Mehr
    Department of Allergy and Immunology, Children s Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales, Australia 2145
    Pediatrics 123:e459-64. 2009

Detail Information

Publications280 found, 100 shown here

  1. ncbi Enterocolitis complicating Hirschsprung's disease
    Daniela Vieten
    Department of Paediatric Surgery, Directorate of Children s Services, Bristol Royal Hospital for Children, Paul O Gorman Building, Upper Maudlin Street, Bristol BS2 8BJ, UK
    Semin Pediatr Surg 13:263-72. 2004
    b>Enterocolitis remains a relatively common complication of Hirschsprung's disease with significant morbidity and mortality. The etiology of Hirschsprung's enterocolitis (HEC) is multifactorial and remains poorly understood...
  2. pmc Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
    Kimberly E Beck
    Surgery Branch and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1201, USA
    J Clin Oncol 24:2283-9. 2006
    ..A report on the diagnosis, pathology, treatment, clinical outcome, and significance of the immune-mediated enterocolitis seen with ipilimumab is presented.
  3. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..and antibody responses are normal, but most animals are growth retarded and anemic and suffer from chronic enterocolitis. Alterations in intestine include extensive mucosal hyperplasia, inflammatory reactions, and aberrant ..
  4. pmc Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10-/- mice via Toll-like-receptor-2 and -4 signaling
    Lea Maxie Haag
    Department of Microbiology and Hygiene, Charite University Medicine Berlin, Berlin, Germany
    PLoS ONE 7:e40761. 2012
    Campylobacter jejuni is a leading cause of foodborne bacterial enterocolitis worldwide. Investigation of immunopathology is hampered by a lack of suitable vertebrate models...
  5. ncbi A multicentre retrospective study of 66 Italian children with food protein-induced enterocolitis syndrome: different management for different phenotypes
    S Miceli Sopo
    Department of Pediatrics, University of Sacred Heart Agostino Gemelli Rome, Rome, Italy
    Clin Exp Allergy 42:1257-65. 2012
    Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE-mediated paediatric disorder triggered by the ingestion of specific food proteins. Many features of this syndrome are not yet well defined.
  6. ncbi The prevalence and natural course of food protein-induced enterocolitis syndrome to cow's milk: a large-scale, prospective population-based study
    Yitzhak Katz
    Allergy and Immunology Institute, Assaf Harofeh Medical Center, Zerifin, Israel
    J Allergy Clin Immunol 127:647-53.e1-3. 2011
    The prevalence and natural history for food protein-induced enterocolitis syndrome (FPIES) have not been determined.
  7. ncbi A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents
    Stefan H Oehlers
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    Dev Dyn 240:288-98. 2011
    ..There was a marked induction of pro-inflammatory cytokines, the degradative enzyme mmp9 and leukocytosis. Enterocolitis was dependent on microbiota and Toll-like receptor signaling, that can be ameliorated by antibiotic and anti-..
  8. ncbi Rice protein-induced enterocolitis syndrome
    Iva Hojsak
    Referral Center for Pediatric Gastroenterology and Nutrition, Zagreb Children s Hospital, Klaiceva 16, HR 10000 Zagreb, Croatia
    Clin Nutr 25:533-6. 2006
    Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergic reaction, usually to cow's milk or soy protein. The aim is to present a series of infants with enterocolitis syndrome developed after rice ingestion...
  9. ncbi Food protein-induced enterocolitis syndrome, from practice to theory
    Stefano Miceli Sopo
    Department of Paediatrics, Catholic University of Sacred Heart, L go Gemelli 8, Rome 00168, Italy
    Expert Rev Clin Immunol 9:707-15. 2013
    Food protein-induced enterocolitis syndrome (FPIES) is an allergic disease, probably non-IgE-mediated, with expression predominantly in the GI tract. The most characteristic symptom is repeated, debilitating vomiting...
  10. ncbi Food protein-induced enterocolitis syndrome: 16-year experience
    Sam Mehr
    Department of Allergy and Immunology, Children s Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales, Australia 2145
    Pediatrics 123:e459-64. 2009
    The goal was to examine the demographic characteristics, causative foods, clinical features, treatments, and outcomes for children presenting with acute food protein-induced enterocolitis syndrome.
  11. ncbi Food protein-induced enterocolitis syndrome
    Anna Nowak-Wegrzyn
    Jaffe Food Allergy Institute, Department of Pediatrics, Mount Sinai School of Medicine, Division of Allergy and Immunology, 1 Gustave L Levy Place, Box 1198, New York, NY 10029, USA
    Curr Opin Allergy Clin Immunol 9:371-7. 2009
    To review current knowledge and recent advances in food protein-induced enterocolitis syndrome (FPIES).
  12. ncbi Rice-induced enterocolitis in an infant: TH1/TH2 cellular hypersensitivity and absent IgE reactivity
    Heather C Gray
    Division of Allergy and Immunology, Department of Pediatrics, Saint Louis University Health Sciences Center, St Louis, Missouri 63110, USA
    Ann Allergy Asthma Immunol 93:601-5. 2004
    ..Although food allergy is common in children, rice allergy is unusual in Western cultures...
  13. ncbi Current understanding of the immune mechanisms of food protein-induced enterocolitis syndrome
    Jean Christoph Caubet
    Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY, USA
    Expert Rev Clin Immunol 7:317-27. 2011
    Food protein-induced enterocolitis syndrome (FPIES) is an under-recognized and frequently misdiagnosed non-IgE-mediated food hypersensitivity disorder, characterized by severe vomiting and/or diarrhea...
  14. ncbi Oxazolone-induced enterocolitis in zebrafish depends on the composition of the intestinal microbiota
    Sylvia Brugman
    Laboratory of Pediatrics, Pediatric Gastroenterology, Erasmus Medical Center, Rotterdam, The Netherlands
    Gastroenterology 137:1757-67.e1. 2009
    ..Interactions between host cells and bacteria are complicated, making it a challenge to assess their relative contribution to intestinal pathology. We developed a zebrafish model of enterocolitis to study these interactions.
  15. ncbi A mouse model for S. typhimurium-induced enterocolitis
    Siegfried Hapfelmeier
    Institute of Microbiology, ETH Honggerberg, Wolfgang Pauli Str 10, 8093 Zurich, Switzerland
    Trends Microbiol 13:497-503. 2005
    ..This mouse model provides a new avenue for research into acute intestinal inflammation because it enables the manipulation and dissection of both the bacterial and host contributions to the disease in unsurpassed detail...
  16. ncbi Food protein-induced enterocolitis syndrome caused by solid food proteins
    Anna Nowak-Wegrzyn
    Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Pediatrics 111:829-35. 2003
    Infantile food protein-induced enterocolitis syndrome (FPIES) is a severe, cell-mediated gastrointestinal food hypersensitivity typically provoked by cow's milk or soy. Solid foods are rarely considered a cause.
  17. ncbi Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 10:39-49. 1999
    ..The mice show a polarized immune response toward the Th1 type and develop chronic enterocolitis with age...
  18. ncbi Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome
    J B Hwang
    Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea
    Arch Dis Child 94:425-8. 2009
    To determine tolerance rates to cow's milk and soy and to suggest guidelines for follow-up oral food challenges (FU-OFCs) in infantile food protein-induced enterocolitis syndrome (FPIES).
  19. ncbi Food protein-induced enterocolitis syndrome: an update on natural history and review of management
    Stephanie A Leonard
    Jaffe Food Allergy Institute, Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann Allergy Asthma Immunol 107:95-101; quiz 101, 162. 2011
    To review the clinical features, pathophysiology, and management of food protein-induced enterocolitis syndrome (FPIES) and to discuss new observations in epidemiology and natural history.
  20. ncbi Can food protein induced enterocolitis syndrome shift to immediate gastrointestinal hypersensitivity? A report of two cases
    R Onesimo
    Department of Pediatrics, Catholic University, Rome
    Eur Ann Allergy Clin Immunol 43:61-3. 2011
    Food protein induced enterocolitis syndrome (FPIES) is a food-related non-IgE-mediated gastrointestinal hypersensitivity disorder. Atypical FPIES is characterized by the presence of specific IgE for the causative food...
  21. ncbi Food protein-induced enterocolitis syndrome--not only due to cow's milk and soy
    Yael Levy
    Kipper Institute of Immunology, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
    Pediatr Allergy Immunol 14:325-9. 2003
    ..period, six patients (four males, two females aged 3-12 months) were diagnosed with food protein-induced enterocolitis syndrome (FPIES) triggered by foods other than cow's milk and soy: chicken in four, turkey in two, peas in one,..
  22. ncbi Manifestations, diagnosis, and management of food protein-induced enterocolitis syndrome
    Stephanie A Leonard
    Division of Pediatric Allergy and Immunology, Rady Children s Hospital, San Diego, CA 92123, USA
    Pediatr Ann 42:135-40. 2013
    CME EDUCATIONAL OBJECTIVES 1. Recognize manifestations, diagnosis, and management of food protein-induced enterocolitis syndrome (FPIES) in an outpatient setting. 2...
  23. pmc Indexes of suspicion of typical cow's milk protein-induced enterocolitis
    Jin Bok Hwang
    Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea
    J Korean Med Sci 22:993-7. 2007
    ..was performed to identify clinical factors that facilitate the diagnosis of typical cow's milk protein-induced enterocolitis (CMPIE)...
  24. ncbi Clinical diagnosis and management of food protein-induced enterocolitis syndrome
    Stephanie A Leonard
    Department of Pediatrics, Division of Allergy and Immunology, University of California, San Diego, California, USA
    Curr Opin Pediatr 24:739-45. 2012
    To provide an overview of clinical manifestations, diagnosis and pathophysiology of food protein-induced enterocolitis syndrome (FPIES), an under-recognized and often misdiagnosed nonimmunoglobulin E-mediated food hypersensitivity...
  25. ncbi Food protein-induced enterocolitis syndrome: insights from review of a large referral population
    MELANIE A RUFFNER
    Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
    J Allergy Clin Immunol Pract 1:343-9. 2013
    Food protein-induced enterocolitis (FPIES) is a rare non-IgE mediated disease. Most studies have been limited in nature, with the largest cohort being 66 patients. The most common foods that have been reported are milk and soy.
  26. pmc The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis
    Philip McKenna
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 4:e20. 2008
    ..This work provides comprehensive data and improved methods for studying the role of commensal microbiota in macaque models of GI diseases and provides a model for the large-scale screening of the human gut microbiome...
  27. ncbi Food protein-induced enterocolitis syndrome: case presentations and management lessons
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 115:149-56. 2005
    b>Enterocolitis induced in infants by cow's milk and/or soy protein has been recognized for decades. Symptoms typically begin in the first month of life in association with failure to thrive and may progress to acidemia and shock...
  28. ncbi Expression of transforming growth factor beta1, transforming growth factor type I and II receptors, and TNF-alpha in the mucosa of the small intestine in infants with food protein-induced enterocolitis syndrome
    Hai Lee Chung
    Department of Pediatrics, Pathology, and Clinical Pathology, School of Medicine, Catholic University of Taegu, Korea
    J Allergy Clin Immunol 109:150-4. 2002
    ..TNF-alpha secreted by activated T cells is known to increase intestinal permeability, whereas transforming growth factor (TGF) beta has the ability to protect the epithelial barrier...
  29. ncbi Radiation enterocolitis requiring surgery in patients with gynecological malignancies
    Shiro Iraha
    Department of Radiology, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Int J Radiat Oncol Biol Phys 68:1088-93. 2007
    To identify the characteristics, risk factors, and clinical outcomes of radiation enterocolitis requiring surgery in patients with gynecologic malignancies.
  30. pmc Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice
    Mariángeles Noto Llana
    Instituto de Microbiología y Parasitología Médica IMPAM CONICET and Departamento de Microbiología, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Infect Immun 80:2231-9. 2012
    In developing countries, one-third of reactive arthritis (ReA) cases are associated with Salmonella enterocolitis; nevertheless, there is no animal model for studying this pathology...
  31. ncbi Food-protein-induced enterocolitis syndrome caused by fish
    L Zapatero Remón
    Section of Pediatric Allergy, Hospital Materno Infantil Gregorio Maranon, Madrid, Spain
    Allergol Immunopathol (Madr) 33:312-6. 2005
    Food protein-induced enterocolitis syndrome (FPIES) occurs in infants. Typical symptoms include profuse vomiting and/or diarrhea several hours after ingestion of a given food. The disorder is a non-IgE mediated food hypersensitivity...
  32. ncbi Allergic enterocolitis presenting as recurrent necrotizing enterocolitis in preterm neonates
    P Srinivasan
    Department of Pediatrics, New York Hospital Queens, Flushing, NY 11355, USA
    J Perinatol 30:431-3. 2010
    An uncommon clinical entity mimicking necrotizing enterocolitis (NEC) is allergic enterocolitis secondary to cow's milk protein allergy...
  33. pmc Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    D J Berg
    Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Clin Invest 98:1010-20. 1996
    ..have associated uncontrolled cytokine production by activated macrophages and CD4+ Th1-like T cells with the enterocolitis exhibited by IL-10-/- mice...
  34. ncbi Usefulness of Atopy Patch Test on a child with milk protein-induced enterocolitis syndrome: a case report
    A Scaparrotta
    Allergy and Respiratory Unit, Department of Pediatrics, University of Chieti, Italy
    Int J Immunopathol Pharmacol 26:795-800. 2013
    We describe the case of a child affected by milk-protein induced enterocolitis, in which oral challenge with corn was performed without symptoms after a negative specific Atopy Patch Test...
  35. pmc Food protein induced enterocolitis syndrome caused by rice beverage
    Lucia Caminiti
    Department of Pediatrics, University of Messina, Messina, Italy
    Ital J Pediatr 39:31. 2013
    Food protein-induced enterocolitis syndrome (FPIES) is an uncommon and potentially severe non IgE-mediated gastrointestinal food allergy...
  36. ncbi Bacteriotherapy using fecal flora: toying with human motions
    Thomas J Borody
    Centre for Digestive Diseases, Sydney, Australia
    J Clin Gastroenterol 38:475-83. 2004
    ..Nevertheless, given the promising clinical responses, formal research into fecal bacteriotherapy is now warranted...
  37. ncbi [A new case of food protein-induced enterocolitis syndrome]
    M Chaabane
    Département mère enfant, Service de Neonatologie, centre hospitalier Sud Essonne, 26, avenue Charles de Gaulle, BP 107, 91152 Etampes cedex 02, France
    Arch Pediatr 17:502-6. 2010
    We report a case of food protein-induced enterocolitis syndrome (FPIES) with milk whose signs of milk intolerance began in the 1st days of life, consisting in minor and nonspecific symptoms...
  38. pmc Lactobacillus reuteri DSM 17938 changes the frequency of Foxp3+ regulatory T cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis
    Yuying Liu
    Divisions of Gastroenterology and Allergy Immunology, Department of Pediatrics, The University of Texas Health Science Center at Houston Medical School, Houston, Texas, USA
    PLoS ONE 8:e56547. 2013
    Necrotizing enterocolitis (NEC) is an inflammatory disease of the intestine in premature infants. Lactobacillus reuteri DSM 17938 improves survival and reduces the incidence and severity of NEC in a rodent model...
  39. ncbi Enterocolitis caused by methicillin-resistant Staphylococcus aureus: molecular characterization of respiratory and digestive tract isolates
    H Watanabe
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Microbiol Immunol 45:629-34. 2001
    We investigated the mechanism of outbreak of enterocolitis caused by methicillin-resistant Staphylococcus aureus (MRSA)...
  40. pmc Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis
    Sandra Guilmeau
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Hospital, Bronx, New York 10467, USA
    Gastroenterology 135:849-60, 860.e1-6. 2008
    ..However, the role of endogenous Notch signaling through receptor-ligand interaction, and effects of its longer term down-regulation on intestinal homeostasis, are unclear...
  41. ncbi Atopy patch test for the diagnosis of food protein-induced enterocolitis syndrome
    Matthew I Fogg
    Division of Allergy and Immunology, Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Allergy Immunol 17:351-5. 2006
    Food protein-induced enterocolitis syndrome (FPIES) is thought to be a non-IgE mediated food allergy syndrome. Affected infants typically demonstrate gastrointestinal symptoms after hours after ingestion of the offending food...
  42. ncbi Do not laparotomize food-protein-induced enterocolitis syndrome
    Shamanthi Jayasooriya
    Centre for Paediatric Gastroenterology, Royal Free and University College School of Medicine, London, UK
    Pediatr Emerg Care 23:173-5. 2007
    Food protein-induced enterocolitis syndrome is a severe cell-mediated, non-immunoglobulin E-mediated gastrointestinal food allergy, typically to milk and soy...
  43. pmc Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease?
    A Cornet
    Institut National de la Santé et de la Recherche Médicale U546 and Immunology Laboratory, Pitie Salpetriere Hospital, Paris 75013, France
    Proc Natl Acad Sci U S A 98:13306-11. 2001
    ..Immune-mediated damage to enteric glia therefore may participate in the initiation and/or the progression of human inflammatory bowel disease...
  44. ncbi Neutropenic enterocolitis in patients with acute leukemia: prognostic significance of bowel wall thickening detected by ultrasonography
    C Cartoni
    Department of Biotecnologie Cellulari ed Ematologia, Policlinico Umberto I, University La Sapienza, Rome, Italy
    J Clin Oncol 19:756-61. 2001
    Neutropenic enterocolitis (NE) is a severe complication of intensive chemotherapy and is barely identifiable by clinical signs alone. Ultrasonography (US) supports the diagnosis of NE by showing pathologic thickening of the bowel wall...
  45. pmc Absence of all components of the flagellar export and synthesis machinery differentially alters virulence of Salmonella enterica serovar Typhimurium in models of typhoid fever, survival in macrophages, tissue culture invasiveness, and calf enterocolitis
    C K Schmitt
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland 20814, USA
    Infect Immun 69:5619-25. 2001
    ..macrophage survival assay, an intestinal epithelial cell adherence and invasion assay, and the calf model of enterocolitis. We found that the flhD mutant was more virulent than its parent in the mouse and displayed slightly faster ..
  46. ncbi Mastocytic enterocolitis: increased mucosal mast cells in chronic intractable diarrhea
    Shriram Jakate
    Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Pathol Lab Med 130:362-7. 2006
    ..In some adult patients with chronic intractable diarrhea, the diagnosis remains elusive even after detailed evaluations, and colonic or duodenal biopsy specimens may appear unremarkable on routine hematoxylin-eosin staining...
  47. ncbi [A case of methicillin resistant Staphylococcus aureus enterocolitis presenting with massive diarrhea]
    Hang Lak Lee
    Department of Internal Medicine, Hanyang University College of Medicine, Gyeonggi, Korea
    Korean J Gastroenterol 42:246-8. 2003
    Methicillin resistant Staphylococcal aureus (MRSA) enterocolitis is characterized by high fever, abdominal distension, and watery diarrhea that leads to severe dehydration, shock, a sharp decrease in the white cell counts and sometimes ..
  48. ncbi Food protein-induced enterocolitis syndrome (FPIES): current management strategies and review of the literature
    Kirsi M Järvinen
    Division of Allergy and Immunology, Albany Medical College, Albany, NY Electronic address
    J Allergy Clin Immunol Pract 1:317-22. 2013
    Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity that manifests as profuse, repetitive vomiting, often with diarrhea, leading to acute dehydration and lethargy or weight ..
  49. ncbi Foaling-management practices associated with the occurrence of enterocolitis attributed to Clostridium perfringens infection in the equine neonate
    L M East
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 West Drake Avenue, Fort Collins, CO 80523, USA
    Prev Vet Med 46:61-74. 2000
    b>Enterocolitis associated with Clostridium perfringens (C. perfringens) infection in neonatal foals is often severe and has been associated with a high case-mortality risk...
  50. ncbi Murine model of Hirschsprung-associated enterocolitis. I: phenotypic characterization with development of a histopathologic grading system
    Zhi Cheng
    Division of Pediatric Surgery and The Pediatric Surgery Laboratory, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Pediatr Surg 45:475-82. 2010
    The aim of the study was to characterize enterocolitis in the Ednrb-null (Ednrb-/-) mouse with aganglionosis of the colon and to develop and validate a semiquantitative histopathologic grading system to assess enterocolitis.
  51. ncbi The ITGB2 immunomodulatory gene (CD18), enterocolitis, and Hirschsprung's disease
    Sam W Moore
    Division of Paediatric Surgery, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, 7505 Tygerberg, South Africa
    J Pediatr Surg 43:1439-44. 2008
    Hirschsprung's disease (HSCR)-associated enterocolitis (HAEC) remains a major contributor to morbidity and mortality associated with HSCR, being sometimes difficult to diagnose in its subclinical form...
  52. ncbi [Clinical study of 18 patients whom MRSA was detected from stool--especially about comparison enterocolitis with colonization]
    H Watanabe
    Department of Internal Medicine, Kyorin Hospital
    Kansenshogaku Zasshi 70:1170-5. 1996
    We studied the clinical aspects of 18 patients from whom MRSA was detected from the stool and compared with 9 enterocolitis cases (7 male, 2 female, median age 72.4 y.o.) with 9 colonization cases (5 male, 4 female, median age 70.2 y.o...
  53. ncbi The pathogenesis of Hirschsprung's disease-associated enterocolitis
    Kelly Miller Austin
    Division of Pediatric General and Thoracic Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Semin Pediatr Surg 21:319-27. 2012
    Hirschsprung's disease-associated enterocolitis (HAEC) remains the most life-threatening complication in Hirschsprung disease (HD) patients...
  54. ncbi MUC-2 mucin production in Hirschsprung's disease: possible association with enterocolitis development
    Aladdein F Mattar
    Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor, Michigan 48109, USA
    J Pediatr Surg 38:417-21; discussion 417-21. 2003
    The etiology of Hirschsprung's-associated enterocolitis (HAEC) is unknown. Previous investigations have suggested that abnormal production of mucins may have an etiologic role. Recently, a series of mucin genes have been identified...
  55. ncbi Long-term outcome of patients with enterocolitis complicating Hirschsprung's disease
    Maria Menezes
    Children s Research Centre, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 22:316-8. 2006
    b>Enterocolitis remains the most serious complication of Hirschsprung's disease (HD). The purpose of this study was to evaluate the risk factors in the development of enterocolitis and the long-term outcome in these patients...
  56. ncbi A case of milk-protein-induced enterocolitis associated with enterotoxigenic E. coli and MRSA infections
    Nemuko Omata
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Eiheiji cho, Yoshida gun, Fukui, 910 1193, Japan
    Eur J Pediatr 167:683-4. 2008
    Food protein-induced enterocolitis (FPIE) is a severe, cell-mediated gastrointestinal food hypersensitivity typically provoked by cow's milk [Joint Task Force of AAAAI and ACAAI Food allergy: a practice parameter. XVII...
  57. pmc The significance of gastric juice analysis for a positive challenge by a standard oral challenge test in typical cow's milk protein-induced enterocolitis
    Jin Bok Hwang
    Department of Pediatrics, Institute for Medical Science, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea
    J Korean Med Sci 23:251-5. 2008
    ..positive challenge in a standard oral cow's milk challenge (OCC) to confirm typical cow's milk protein-induced enterocolitis (CMPIE). Data from 16 CMPIE patients (aged 14 to 44 days) were analyzed...
  58. ncbi Extensively hydrolyzed formula (MA-mi) induced exacerbation of food protein-induced enterocolitis syndrome (FPIES) in a male infant
    Tomoyuki Kabuki
    Division of Infectious Diseases, Immunology and Allergy, Saitama Children s Medical Center, Saitama, Japan
    Allergol Int 56:473-6. 2007
    Food protein-induced enterocolitis syndrome (FPIES) is a severe, cell-mediated food allergy in which digestive symptoms such as severe vomiting and diarrhea are induced by cow's milk and/or soy protein in infants...
  59. pmc Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome
    Laurence E Cheng
    Department of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, CA 94143, USA
    Clin Immunol 132:124-31. 2009
    ..of erythrocyte sedimentation rates in five patients, and two were symptomatic, with a chronic but atypical enterocolitis. Though pathologic lesions in these two patients were consistent with acute inflammation, sustained clinical ..
  60. ncbi [CMV-associated enterocolitis due to primary CMV infection in the immunocompetent]
    C D Spinner
    II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen
    Z Gastroenterol 51:1259-63. 2013
    ..In a severe case, we recommend antiviral therapy due to a high mortality that has been reported for CMV colitis in immunocompetent individuals...
  61. ncbi The pendulum between food protein-induced enterocolitis syndrome and IgE-mediated milk allergy
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel
    Acta Paediatr 100:e183-5. 2011
    The transition from milk protein-induced enterocolitis syndrome to IgE-mediated milk allergy is uncommon...
  62. ncbi Solid-food introduction in infants diagnosed as having a cow's-milk protein-induced enterocolitis
    Josée N Beauchamp
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    J Pediatr Gastroenterol Nutr 52:639-43. 2011
    In a prior retrospective analysis of 32 infants diagnosed with cow's-milk protein-induced enterocolitis (CMPIE), gastrointestinal (GI) symptoms were observed with the introduction of milk-free infant cereal...
  63. ncbi Allergic proctocolitis, food-induced enterocolitis: immune mechanisms, diagnosis and treatment
    J Bone
    Miguel Servet Hospital, Zaragoza, Spain
    Allergol Immunopathol (Madr) 37:36-42. 2009
    ..The gastrointestinal problems derived from these delayed or chronic reactions comprise allergic proctocolitis, enterocolitis and food protein enteropathies...
  64. ncbi Sodium cromoglycate in the management of chronic or recurrent enterocolitis in patients with Hirschsprung's disease
    R J Rintala
    Children's Hospital, University of Helsinki, Finland
    J Pediatr Surg 36:1032-5. 2001
    BACKGROUND/PURPOSE: Chronic or recurring enterocolitis is a rare but perplexing complication of Hirschsprung's disease affecting especially patients with altered immune defense such as those with Down's syndrome...
  65. ncbi IBD and IBD mimicking enterocolitis in children younger than 2 years of age
    Z Cannioto
    Department of Reproduction and Development Sciences, University of Trieste IRCCS Burlo Garofolo, Trieste, Italy
    Eur J Pediatr 168:149-55. 2009
    ..Some severe immunodeficiencies, such as WAS and CGD, may represent a problem in terms of differential diagnosis and might be wrongly diagnosed as very early onset IBD...
  66. ncbi Abnormalities in liver enzyme levels during Salmonella enteritidis enterocolitis
    A Gonzalez-Quintela
    Department of Internal Medicine, Hospital Clinico Universitario, Santiago de Compostela, A Coruna, Spain
    Rev Esp Enferm Dig 96:559-62; 563-6. 2004
    To evaluate the prevalence, associated factors, and time-course changes of abnormal liver enzyme serum levels in adult patients with Salmonella enteritidis enterocolitis.
  67. pmc Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitis
    Brian K Coombes
    Michael Smith Laboratories, 301 2185 East Mall, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Infect Immun 73:7161-9. 2005
    ..These data delineate novel phenotypes for SPI-1 and SPI-2 mutants in the intestinal phase of bovine and murine salmonellosis and provide working models to further investigate the effector contribution to these pathologies...
  68. ncbi New insights into the pathogenesis of Hirschsprung's associated enterocolitis
    Feilim Murphy
    The Children s Research Centre, Our Lady s Hospital for Sick Children Crumlin, University College Dublin, Dublin 12, Ireland
    Pediatr Surg Int 21:773-9. 2005
    ..However, although our appreciation of Hirschsprung's associated enterocolitis and its aetiology has increased, there are continued references in the literature to a multitude of theories ..
  69. ncbi Efficacy of Saccharomyces boulardii for treatment of horses with acute enterocolitis
    Anne M Desrochers
    Department of Clinical Studies, New Bolton Center Campus, University of Pennsylvania, Kennett Square PA 19348, USA
    J Am Vet Med Assoc 227:954-9. 2005
    To evaluate the viability of Saccharomyces boulardii after PO administration in clinically normal horses and its efficacy as a treatment for horses with acute enterocolitis.
  70. pmc Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis
    Stefan H Oehlers
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland 1142, New Zealand
    Dis Model Mech 5:457-67. 2012
    ..This study reports the characterization of a novel zebrafish larval model of IBD-like enterocolitis induced by exposure to dextran sodium sulfate (DSS)...
  71. ncbi Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
    Sandra C Kim
    Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC 27599 7032, USA
    Gastroenterology 128:891-906. 2005
    ....
  72. ncbi Erosive enterocolitis in mycophenolate mofetil-treated renal-transplant recipients with persistent afebrile diarrhea
    Bart D Maes
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Transplantation 75:665-72. 2003
    ..The aim of this study was to explore the gastrointestinal tract in MMF-treated renal transplant recipients with persistent afebrile diarrhea to characterize its nature and etiology...
  73. pmc Eosinophilic cystitis associated with eosinophilic enterocolitis: case reports and review of the literature
    M S Kim
    Department of Radiology, Myongji Hospital, Kwandong Univerisity College of Medicine, Korea
    Br J Radiol 83:e122-5. 2010
    ..Eosinophilic cystitis might have been associated with eosinophilic infiltration in other organs, such as the gastrointestinal tracts and liver...
  74. ncbi An outbreak of necrotizing enterocolitis associated with a novel clostridium species in a neonatal intensive care unit
    Michelle J Alfa
    St Boniface General Hospital, and University of Manitoba, Winnipeg, Manitoba, Canada R2H 2A6
    Clin Infect Dis 35:S101-5. 2002
    An outbreak of necrotizing enterocolitis (NEC) occurred in 6 neonates within a 2-month period...
  75. ncbi [Hemorrhagic colitis caused by dasatinib following cytomegalovirus enterocolitis in a patient with chronic myelogenous leukemia in the second chronic phase]
    Yoshitaka Sunami
    Department of Hematology, Juntendo University School of Medicine, Japan
    Rinsho Ketsueki 52:282-6. 2011
    ..Dasatinib-related gastrointestinal bleeding is less frequent in Japan compared to that in western countries, and Japanese cases diagnosed as having hemorrhagic colitis are extremely rare...
  76. ncbi Secondary sclerosing cholangitis and portal hypertension after O157 enterocolitis: Extremely rare complications of hemolytic uremic syndrome
    N Urushihara
    Department of Surgery, Okayama University Medical School, Okayama, Japan
    J Pediatr Surg 36:1838-40. 2001
    ..Sclerosing cholangitis and subsequent cirrhosis with portal hypertension are very uncommon as late complications of HUS. To our knowledge, such a case has not been previously reported in the literature. J Pediatr Surg 36:1838-1840...
  77. ncbi Abdominal ultrasonographic findings in typhoid fever: a comparison between typhoid patients and those with non-typhoidal Salmonella and Campylobacter jejuni enterocolitis
    Akira Kobayashi
    Nanmei kai Miyagami Hospital, Kagoshima, Japan
    Southeast Asian J Trop Med Public Health 43:423-30. 2012
    ..health problem in many developing countries and its clinical features are similar to other types of bacterial enterocolitis. Definitive diagnosis by blood culture requires several days and is often unfeasible to perform in developing ..
  78. ncbi The fatal outcome of an individual with anorexia nervosa and Sheehan's syndrome as a result of acute enterocolitis: a case report
    Werner Kopp
    University Hospital Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Eat Disord 43:93-6. 2010
    ..To illustrate the close association between a disturbed psychosocial up-bringing, frequent physical illness, and medical interventions...
  79. ncbi Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats
    R D McCall
    Department of Internal Medicine, University of North Carolina at Chapel Hill
    Gastroenterology 106:960-72. 1994
    ..purified group A streptococcal peptidoglycan-polysaccharide (PG-APS) induces chronic relapsing granulomatous enterocolitis and systemic inflammation in susceptible inbred Lewis rats but only transient intestinal injury in Buffalo and ..
  80. ncbi CDX-1 and CDX-2 are expressed in human colonic mucosa and are down-regulated in patients with Hirschsprung's disease associated enterocolitis
    V C Lui
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, SAR, PR China
    Biochim Biophys Acta 1537:89-100. 2001
    ..anomaly of intestine, which causes functional intestinal obstruction, is frequently associated with enterocolitis. Aetiology of HD-associated enterocolitis (HDEC) remains obscure...
  81. pmc Effect of oral administration of Butyrivibrio fibrisolvens MDT-1 on experimental enterocolitis in mice
    Sou Ohkawara
    Department of Life Science, College of Agriculture, Meiji University, Higashimita, Tama ku, Kawasaki 214 8571, Japan
    Clin Vaccine Immunol 13:1231-6. 2006
    Butyrivibrio fibrisolvens MDT-1, a butyrate-producing strain, was evaluated for use as a probiotic to prevent enterocolitis. Oral administration of the MDT-1 strain (10(9) CFU/dose) alleviated the symptoms of colitis (including body ..
  82. pmc Genetic dissection of granulomatous enterocolitis and arthritis in the intramural peptidoglycan-polysaccharide-treated rat model of IBD
    A Bleich
    Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany
    Inflamm Bowel Dis 15:1794-802. 2009
    ..As genetic susceptibility plays an important role in the etiology of IBD, we questioned how granulomatous enterocolitis and arthritis are genetically controlled in an experimental animal model displaying both conditions.
  83. pmc Autistic enterocolitis: fact or fiction?
    Polymnia Galiatsatos
    Department of Medicine, The Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Can J Gastroenterol 23:95-8. 2009
    ..Two autism spectrum disorder patients with chronic intestinal symptoms and abnormal endoscopic findings are described, followed by a review of this controversial topic...
  84. ncbi Rice: a common and severe cause of food protein-induced enterocolitis syndrome
    S S Mehr
    Department of Allergy and Immunology, The Children s Hospital at Westmead, Sydney, Australia
    Arch Dis Child 94:220-3. 2009
    To examine and compare the characteristics of food protein-induced enterocolitis syndrome (FPIES) caused by rice and cow's milk/soy.
  85. ncbi Successful conservative management of neutropenic enterocolitis: a report of two cases and review of the literature
    Kevin O'Connor
    Department of Surgery, St Vincent s University Hospital, and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
    ANZ J Surg 73:463-5. 2003
  86. ncbi Autistic enterocolitis; is it a histopathological entity?
    T T MacDonald
    Institute of Cell and Molecular Science and Health Sciences Education, Bart s and the London Queen Mary School of Medicine and Dentistry, London, UK
    Histopathology 50:371-9; discussion 380-4. 2007
    To review the literature on the histopathological diagnosis of the condition termed 'autistic enterocolitis'.
  87. ncbi [Case of food protein-induced enterocolitis syndrome caused by short-neck clam ingestion]
    Daisuke Hayashi
    Tsukuba Medical Center Hospital
    Arerugi 59:1628-33. 2010
    ..He was therefore diagnosed with food protein-induced enterocolitis syndrome (FPIES) due to short-neck clam ingestion...
  88. ncbi CT findings in eosinophilic enterocolitis with predominantly serosal and muscular bowel wall infiltration
    W Wiesner
    Institute of Diagnostic Radiology, University Hospital Basel, Switzerland
    JBR-BTR 85:4-6. 2002
    ..In context with the known blood eosinophilia the diagnosis of an eosinophilic enterocolitis was suspected already by CT but finally only surgical full thickness biopsies could confirm the rare diagnosis ..
  89. pmc Application of 16S rRNA gene PCR to study bowel flora of preterm infants with and without necrotizing enterocolitis
    M R Millar
    Department of Pathology and Microbiology, University of Bristol, Avon, United Kingdom
    J Clin Microbiol 34:2506-10. 1996
    ..contribute to the microbial flora of the bowel of preterm infants with and without neonatal necrotizing enterocolitis (NEC)...
  90. ncbi Neutropenic enterocolitis
    Mary F Bavaro
    Department of Infectious Disease, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708, USA
    Curr Gastroenterol Rep 4:297-301. 2002
    Neutropenic enterocolitis is an acute syndrome characterized by cecal and ascending colon inflammation that may progress to necrosis and perforation...
  91. ncbi Severe cytomegalovirus enterocolitis in an immunocompetent infant
    Chokechai Rongkavilit
    Division of Infectious Diseases, Department of Pediatrics, Wayne State University School of Medicine and Childrens Hospital of Michigan, Detroit, MI, USA
    Pediatr Infect Dis J 23:579-81. 2004
    ..It is a rare cause of enterocolitis in immunocompetent hosts...
  92. pmc Secreted effector proteins of Salmonella enterica serotype typhimurium elicit host-specific chemokine profiles in animal models of typhoid fever and enterocolitis
    Shuping Zhang
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843 4467, USA
    Infect Immun 71:4795-803. 2003
    ..Thus, different disease outcomes between mice (i.e., no diarrhea) and calves (i.e., diarrhea) may be due to differences in sipA sopABDE2-dependent CXC chemokine gene expression in epithelial cells...
  93. ncbi Prevalence of ischemic enterocolitis in patients with acute pancreatitis
    Yoshihisa Takahashi
    Department of Pathology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    J Gastroenterol 40:827-32. 2005
    ..However, no reports have ever referred to the incidence of ischemic enterocolitis in patients with acute pancreatitis, using a series of autopsy cases...
  94. ncbi Staphylococcal enterocolitis: forgotten but not gone?
    Zheng Lin
    Division of Gastroenterology, Department of Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Dig Dis Sci 55:1200-7. 2010
    Staphylococcus aureus may cause antibiotic-associated diarrhea and enterocolitis, with or without preceding antibiotic use, in immunocompromised adults or infants, or individuals with predisposing conditions, but there is little ..
  95. ncbi Serum cytokines in differentiating between viral and bacterial enterocolitis
    Chun Yan Yeung
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China
    Ann Trop Paediatr 24:337-43. 2004
    It is difficult to distinguish clinically between bacterial and viral causes of enterocolitis. The aim of the study was to investigate if serum cytokines can distinguish bacterial from viral enterocolitis...
  96. pmc Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitis
    Bryan Coburn
    Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada
    Infect Immun 73:3219-27. 2005
    ..type III secretion systems, we demonstrate that SPI2 is essential for complete virulence in murine infectious enterocolitis. Using a recently characterized murine model (M. Barthel,S. Hapfelmeier, L. Quintanilla-Martinez, M. Kremer, M...
  97. pmc Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
    Masaya Kobayashi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Clin Invest 111:1297-308. 2003
    ..cell-specific deletion of Stat3 resulted in inflammatory cytokine production and development of chronic enterocolitis with enhanced Th1 responses in mice...
  98. ncbi Perforation of toxic megacolon in non-typhoid Salmonella enterocolitis spares young infants and is immune-mediated
    C H Chiu
    Department of Pediatrics, Chang Gung Children s Hospital, 5 Fu Hsin Street, Kweishan 333, Taoyuan, Taiwan, ROC
    Pediatr Surg Int 18:410-2. 2002
    ..The situation, also found in typhoid fever, appears to be cytokine-mediated. This finding may justify immunotherapy for older children with TM associated with non-typhoid Salmonella infection in order to prevent this complication...
  99. ncbi Intussusception due to Yersinia enterocolitica enterocolitis in a patient with beta-thalassemia
    M G Hansen
    Department of Pathology, Orlando Regional Medical Center, 1414 South Orange Ave, Orlando, FL 32806, USA
    Arch Pathol Lab Med 125:1486-8. 2001
    ..His monthly blood transfusions for this condition may have put him at risk for Y enterocolitica enterocolitis. The pathogenesis of this disease relates to the role of iron as an essential growth factor for Yersinia, and ..
  100. ncbi Educational clinical case series for pediatric allergy and immunology: allergic proctocolitis, food protein-induced enterocolitis syndrome and allergic eosinophilic gastroenteritis with protein-losing gastroenteropathy as manifestations of non-IgE-mediate
    Jennifer Maloney
    Mount Sinai School of Medicine, Department of Pediatrics, Division of Allergy and Immunology and Jaffe Food Allergy Institute, New York, NY 10029, USA
    Pediatr Allergy Immunol 18:360-7. 2007
    ..Most infants tolerate cow's milk by their first birthday. Food protein-induced enterocolitis syndrome presents in young formula-fed infants with chronic emesis, diarrhea, and failure to thrive...
  101. ncbi Crohn's-like colitis, enterocolitis and perianal disease in Hermansky-Pudlak syndrome
    D Hazzan
    Department of Surgery, Mount Sinai Hospital, New York, NY 10029, USA
    Colorectal Dis 8:539-43. 2006
    ..patients also reportedly have gastrointestinal (GI) complications related to chronic granulomatous colitis, enterocolitis and extensive granulomatous perianal disease, the later previously unreported in the literature...

Research Grants77

  1. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..feasibility study to test the hypothesis that very-low-birth- weight neonates (VLBW) who develop necrotizing enterocolitis (NEC) can be reliably detected early in the process using broadband optical spectroscopy sensitive to changes ..
  2. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..invasion of neonatal intestinal epithelia and consequently to limit systemic bacteremia and necrotizing enterocolitis (NEC). The overall incidence of prospectively studied NIs in hospitalized neonates has been reported to be 10...
  3. Intracellular Serpin Regulation of Intestinal Cell Necrosis
    GARY ARTHUR SILVERMAN; Fiscal Year: 2012
    ..gastrointestinal disorders including inflammatory bowel disease, infectious gastroenteritis and necrotizing enterocolitis. Although the etiology of intestinal cell necrosis is uncertain, risk factors include anisotonic fluids, ..
  4. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Necrotizing enterocolitis (NEC) is a life-threatening, gastrointestinal emergency that occurs in 7 to 10% very low birth weight (VLBW, <1500 g) infants...
  5. Novel Therapeutic Targets in Necrotizing Enterocolitis
    Peter J Giannone; Fiscal Year: 2012
    Necrotizing enterocolitis (NEC), a major cause of morbidity and mortality in neonatal intensive care units, is a disease for which there is currently no medical treatment. Treatment of infants that develop NEC is solely supportive...
  6. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..as intraventricular hemorrhage, nosocomial infections and sepsis, days on mechanical ventilation, necrotizing enterocolitis and chronic lung disease...
  7. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2010
    ..perforation and obstruction of the lower GI tract, which can be manifest in the related diseases Necrotizing Enterocolitis (NEC) and Spontaneous Intestinal Perforation (SIP)...
  8. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2013
    ..perforation and obstruction of the lower GI tract, which can be manifest in the related diseases Necrotizing Enterocolitis (NEC) and Spontaneous Intestinal Perforation (SIP)...
  9. Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants
    Leslie A Parker; Fiscal Year: 2013
    ..Increased volumes have been thought to be related to feeding intolerance or an early symptom of necrotizing enterocolitis. In critically ill children and adults increased volumes have also bee thought to be associated with ..
  10. Regulation of Intestinal Epithelial Tight Junction Barrier
    Thomas Y Ma; Fiscal Year: 2011
    ..variety of inflammatory diseases of the gut (including Crohn's disease, ulcerative colitis, necrotizing enterocolitis, NSAID associated enteritis, and infectious diarrheal syndromes) and systemic inflammatory conditions (..
  11. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..Intestinal inflammation occurs in intestinal disorders besides IBD, including necrotizing enterocolitis, infectious diarrhea, and irritable bowel syndrome;the ENS may contribute to any or all of them...
  12. Modulation of TLR4 and TLR9 Signaling in NEC
    David J Hackam; Fiscal Year: 2013
    ..The goals of the proposed research are to determine the mechanisms that lead to the development of necrotizing enterocolitis (NEC), which is the leading cause of death and disability from gastrointestinal disease in premature infants, ..
  13. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2013
    ..implicated in the pathogenesis of a wide spectrum of intestinal inflammatory diseases including necrotizing enterocolitis, inflammatory bowel disease and infectious enterocolitis...
  14. Validation in Baboon Model of Broadband NIR Monitoring for Neonate Gut Perfusion
    David A Benaron; Fiscal Year: 2012
    ..is manifested by feeding intolerance, poor growth, malabsorbtion, and, in the severest cases, necrotizing enterocolitis (NEC)...
  15. Epithelium, dendritic cells, and Clostridium difficile associated colitis
    Hanping Feng; Fiscal Year: 2013
    ..TNF-a synergizes with the toxins to induce apoptosis of IECs, thus exacerbating tissue destruction and enterocolitis. By testing these hypotheses, we expect to gain a better understanding of not only the underlying mechanisms ..
  16. The roles of MKP-1 in Gram-negative bacterial sepsis and colitis
    Yusen Liu; Fiscal Year: 2010
    ..will unravel critical regulatory mechanisms that govern the immune response to infection and prevent chronic enterocolitis and may lead to novel strategies for the treatment of sepsis and IBD...
  17. Probiotics and Innate Intestinal Defense
    PATRICIA LANEE WEI DENNING; Fiscal Year: 2013
    Abstract: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in the neonatal intensive care unit (NICU)...
  18. Maturation of intestinal innate immunity and NEC
    W Allan Walker; Fiscal Year: 2013
    ..to bacterial exposure could lead to generalized inflammation and bowel necrosis, such as occurs in necrotizing enterocolitis (NEC)...
  19. PAF Receptor Trafficking and Function in Epithelial Cells
    Tamas Jilling; Fiscal Year: 2010
    ..of gastrointestinal diseases such as Crohn's disease, ulcerative colitis and neonatal necrotizing enterocolitis (NEC). The PAF receptor (PAFR) is a member of the G protein-coupled receptor (GPCR) superfamily...
  20. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2013
    Necrotizing enterocolitis (NEC) is a life-threatening inflammatory bowel disorder of unknown cause that affects approximately 10% of premature infants born <1500gm...
  21. Temperature & Vasomotor Tone During the First 5 Days in Preterms Less than 1000g
    ROBIN BRITT KNOBEL; Fiscal Year: 2010
    ..between the maturation of vasomotor tone and morbidity--intraventricular hemorrhage (IVH) and necrotizing enterocolitis (NEC)--in ELBW infants. Methods: Consent will be obtained from parents prior to infant birth...
  22. Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.
    Ardythe L Morrow; Fiscal Year: 2013
    ..Beneficial early bacterial colonization of the intestinal tract is known to help prevent necrotizing enterocolitis (NEC)...
  23. Human Milk Factor Protection in Neonatal Necrotizing Enterocolitis
    Sheng Ru Shiou; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Necrotizing enterocolitis (NEC) is a life-threatening inflammatory bowel disorder that affects approximately 10% of premature infants with a birth weight lower than 1500 grams...
  24. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2009
    ..implicated in the pathogenesis of a wide spectrum of intestinal inflammatory diseases including necrotizing enterocolitis, inflammatory bowel disease and infectious enterocolitis...
  25. Regulation of TLR4 Signaling in Enterocytes in Necrotizing Enterocolitis
    Amin Afrazi; Fiscal Year: 2013
    ..current proposal is to understand the pathogenesis and to design novel therapeutic approaches for necrotizing enterocolitis (NEC)...
  26. ET3-EDNRB Signaling in Enterocolitis Associated with Colonic Aganglionosis
    PHILIP KENT FRYKMAN; Fiscal Year: 2013
    ..But in up to 30% of cases, surgery fails to cure the disorder, and thereafter, children suffer from chronic enterocolitis that can lead to bacteremia, outright sepsis, and even death...
  27. The role of PhoP/PhoQ-regulated phospholipid alterations in Salmonella pathogenes
    ZACHARY DALEBROUX; Fiscal Year: 2013
    ..is a Gram-negative pathogen of worldwide importance causing a variety of diseases including typhoid fever, enterocolitis and bacteremia. Following ingestion of contaminated products, bacteria access the human small intestine...
  28. Intestinal Barrier Function: Protective Effects of Curcumin
    Pawel R Kiela; Fiscal Year: 2013
    ..In a number of inflammatory human diseases, including ischemic bowel injury, necrotizing enterocolitis, and idiopathic inflammatory bowel disease, intense neutrophil transepithelial migration is a prevalent ..
  29. Role of Transforming Growth Factor-beta in Neonatal Necrotizing Enterocolitis
    Akhil Maheshwari; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Necrotizing enterocolitis (NEC) is an acquired, life-threatening gastrointestinal disease affecting 5-15% of neonates born weighing less than 1500 g and is a leading cause of death in these patients...
  30. Cell-specific role of NF-KB in necrotizing enterocolitis
    Isabelle G De Plaen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Necrotizing enterocolitis (NEC) remains one of the most devastating diseases affecting premature babies and is the leading cause of intestinal failure in infancy, with currently no specific treatment ..
  31. Enteric nervous system deficits in Hirschsprung ganglionic bowel
    MELISSA MUSSER; Fiscal Year: 2013
    ..However, many patients continue to suffer from intestinal dysfunction, including motility disorders and enterocolitis, despite the presence of ganglia in the intact proximal bowel...
  32. Multiple Chronic Conditions in VLBW Infants: Epidemiology, NICU Care, and Outcome
    William Gardner; Fiscal Year: 2010
    ..Specifically, PVLBW children are at high risk for bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), and intraventricular hemorrhages (IVH)...
  33. InCell 6000 High Content Instrument for Cellular Systems Biology Program
    D LANSING LANSING TAYLOR; Fiscal Year: 2013
    ..in model systems, protein misfolding disease model of alpha 1- antitrypsin deficiency (ATD), and necrotizing enterocolitis (NEC) models in C. elgans...
  34. TLR4 signaling in the pathogenesis of surgical necrotizing enterocolitis
    David J Hackam; Fiscal Year: 2013
    ..The goals of the proposed research are to determine the mechanisms that lead to the development of necrotizing enterocolitis (NEC), which is the leading cause of death and disability from gastrointestinal disease in premature infants, ..
  35. The Neonatal Microbiome and Necrotizing Enterocolitis
    Phillip I Tarr; Fiscal Year: 2012
    Necrotizing enterocolitis (NEC) is a devastating disorder that affects approximately 10% of premature infants. Its mortality remains high (15-30%), and its cause remains unknown...
  36. KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASE
    Robert Colman; Fiscal Year: 2001
    ..In the view of the efficacy of plasma kallikrein inhibitors in blocking enterocolitis, we will use recombinant HK derivatives and peptides derived from HK which can distinguish in vitro whether ..
  37. Effect of cysteine on glutathione production in critically ill neonates
    STEPHEN SHEW; Fiscal Year: 2010
    ..a high incidence of disease associated with oxidative-injury, such as chronic lung disease and necrotizing enterocolitis. Cysteine is the rate limiting substrate for the synthesis of glutathione, but it is not readily synthesized ..
  38. The association between preterm milk immunobiology and infant health
    MAUREEN EDITH GROER; Fiscal Year: 2013
    ..weight gain, time to discharge, and any significant adverse health outcomes such as infections or necrotizing enterocolitis. This will be the first careful study that will provide a computation of human milk factors and volumes across ..
  39. Chaperone Mechanisms in Innate Immunity
    Zihai Li; Fiscal Year: 2013
    ..in canonical Wnt signaling such that when gp96 is deleted from the gut, mice develop a profound and lethal enterocolitis. Second, when gp96 was selectively knocked down from macrophages, we observed a significant attenuation of ..
  40. Qualifying Studies of Biomarkers for Neonatal Disease
    Karl G Sylvester; Fiscal Year: 2013
    ..Many sources of infection including blood-stream infections (sepsis) and necrotizing enterocolitis (NEC) are both common and unique to the neonate as is the systemic response observed in this patient ..
  41. Safety and Effect of L. reuteri on Biomarkers of Inflammation in Healthy Infants
    Jon Marc Rhoads; Fiscal Year: 2013
    ..reuteri reduced gut inflammation and reduced mortality by >50% in a neonatal rat model of necrotizing enterocolitis. We are currently close to completion of a double-blind placebo-controlled Phase 1 safety trial of L...
  42. Butyrate regulation of intestinal barrier
    Jing Lin; Fiscal Year: 2010
    ..enteral formula feeding, and bacterial colonization are three major risk factors for neonatal necrotizing enterocolitis (NEC). The hallmark pathologic findings in NEC are intestinal mucosal injuries...
  43. Adequate Breast Milk for Improved Health of Very Low Birth Weight Preterm Infants
    Leslie A Parker; Fiscal Year: 2013
    ..from prematurity-specific morbidities, including feeding intolerance, late onset sepsis, and necrotizing enterocolitis. Unfortunately, mothers of VLBW infants often exhibit delayed lactogenesis stage II (when the milk "comes in") ..
  44. Cooperative Multicenter Network of Neontal Intensive Care Units
    Seetha Shankaran; Fiscal Year: 2013
    ..to the outcome of ELBW infants participating in the ongoing NRN RCT of Laparotomy versus Drain for Necrotizing Enterocolitis or Isolated Intestinal Perforations and Dr...
  45. Maternal, Clinician &Hospital Factors in Breastmilk for Premature Infants
    Henry Chong Lee; Fiscal Year: 2013
    ..as the optimal feeding choice for premature infants as it prevents serious morbidities such as necrotizing enterocolitis. Nevertheless, many premature infants are not being fed breast milk by the time they are discharged home from ..
  46. Multi-Dimensional Separation of Bacteria
    G Scott Worthen; Fiscal Year: 2010
    ..such as in clinical infectious illnesses (we are particularly interested in Bronchiectasis and necrpotizing enterocolitis) whose pathogenesis is obscure...
  47. Tolerance to TLR Ligands in the Intestinal Epithelium
    Anatoly V Grishin; Fiscal Year: 2010
    ..lead to better understanding of the pathogenesis of the intestinal inflammatory disorders such as necrotizing enterocolitis, and, ultimately, better therapies...
  48. Pathogenic effector protein modulation of host innate immune signaling
    RHEINALLT MELFYN JONES; Fiscal Year: 2010
    Intestinal enterocolitis caused by food borne pathogens is a substantial health burden in the United States and internationally...
  49. Necrotizing Enterocolitis: Prevention and Prediction
    MARK ALAN UNDERWOOD; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Effective preventive agents and biomarkers predictive of high-risk infants are significant clinical needs...
  50. Role of Paneth Cells in Development of Necrotizing Enterocolitis
    STEVEN JAMES MCELROY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neonatal necrotizing enterocolitis (NEC) is the single most devastating gastrointestinal cause of mortality and morbidity in premature infants...
  51. Translational Regulation of Gene Expression in Neonatal PMNs
    Christian Con Yost; Fiscal Year: 2010
    ..of the acute inflammatory response such as chronic lung disease, overwhelming sepsis and necrotizing enterocolitis (NEC). NEC is a disease of infants born prematurely that commonly leads to significant morbidity or death...
  52. Intestinal Microecology, Inflammatory Markers and Necrotizing Enterocolitis
    Josef Neu; Fiscal Year: 2013
    ..the first comprehensive evaluation of the intestinal microbiota in premature infants at risk for necrotizing enterocolitis (NEC). The overall goals respond to objectives of the NIH Funding Opportunity Announcement, which include: 1...
  53. Cross-talk between iron metabolism and intestinal inflammation
    BOBBY JOSEPH CHERAYIL; Fiscal Year: 2013
    ..The abnormality manifests in vivo as a reduction in the severity of Salmonella- induced enterocolitis. In additional studies with wild-type (WT) mice and with mouse models of inflammatory bowel disease (IBD), we ..
  54. Development of Intestinal Immune Regulation in Human Infants
    JOERN HENDRIK WEITKAMP; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Necrotizing enterocolitis (NEC) in preterm infantsjs...
  55. Roche 454 GL FLX DNA Sequencer
    WILLIAM GEORGE FARMERIE; Fiscal Year: 2010
    ..transmission, and the comparative metagenomics of the microbiome in human infants at risk for necrotizing enterocolitis. In between are projects for understanding the role of chronic mycoplasma infection in prostate cancer, ..
  56. Population genomic analysis of gut microbial colonization in premature infants
    David A Relman; Fiscal Year: 2013
    ..in gut microbial succession are related to health and disease, and specifically to neonatal necrotizing enterocolitis (NEC)...
  57. Mechanisms of Gastrointestinal Epithelial Cell Injury &Repair During Development
    STEVEN JAMES MCELROY; Fiscal Year: 2013
    ..One of the most devastating is necrotizing enterocolitis (NEC), which yearly kills 12 babies per 100,000 live births in the USand frequently leaves survivors with ..
  58. Validating a Necrotizing Enterocolitis (NEC) Risk Index for Neonates
    SHEILA MARIA GEPHART; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Background: Necrotizing Enterocolitis (NEC) is the most common gastrointestinal emergency for premature infants. It is a costly disease and a primary cause of neonatal morbidity and mortality...
  59. Fusing Glycobiology and Nutritional Sciences to Prevent Necrotizing Enterocolitis
    Lars Bode; Fiscal Year: 2009
    ..Formula-feeding significantly increases the risk to develop necrotizing enterocolitis (NEC), the most frequent and most lethal disorder in neonates...
  60. Development of an SPF Macaca nemestrina Breeding Colony
    Robert J Adams; Fiscal Year: 2013
    ..3) To determine whether either MHC class I allele expression or SNPs are associated with a) SIV-related disease outcomes and b) naturally occurring enterocolitis in pig-tailed macaques.
  61. Glycomics Equipment: NanoLC CHIP-QTOF Mass Spectrometer
    Carlito B Lebrilla; Fiscal Year: 2010
    ..Jay Solnick, School of Medicine), (2) The effect of prebiotics and probiotics in necrotizing enterocolitis (Dr...
  62. EEG synchrony of preterm infants: Regional disparities and perinatal risks
    Philip Grieve; Fiscal Year: 2009
    ..CLD), weight and age at birth, intrauterine growth restriction (IUGR), sepsis, chorioamnionitis, necrotizing enterocolitis, use of postnatal steroids, and sex...
  63. FIBROSIS IN CROHNS DISEASE--ROLE OF IGF I
    ELLEN ZIMMERMANN; Fiscal Year: 1999
    ..from patients with Crohn's disease and in rats with peptidoglycan-polysaccharide (PG-PS) induced chronic enterocolitis, a model of Crohn's disease...
  64. Use of Probiotic Conditioned Media to Protect Against Necrotizing Enterocolitis
    ERIKA CLAUD; Fiscal Year: 2009
    Necrotizing enterocolitis (NEC), an inflammatory bowel necrosis that primarily afflicts preterm infants after the initiation of enteral feeds, is likely the result of synergy of several risk factors including altered intestinal barrier ..
  65. A Transcutaneous Gas Sensor for Noninvasive Diagnosis of Necrotizing Enterocoliti
    OOMMAN VARGHESE; Fiscal Year: 2009
    ..Measurement of the transcutaneous gases will be used for detecting possible acidosis and necrotizing enterocolitis (NEC)...
  66. Role of NO and Endothelin in Human NEC
    GAIL BESNER; Fiscal Year: 2007
    ..a novel hypothesis regarding the pathogenesis of the ischemia which precedes the development of necrotizing enterocolitis (NEC), the most common acquired gastrointestinal disease of infancy and a major contributor to neonatal ..
  67. Short-Chain Fatty Acid Enhanced Intestinal Adaptation
    KELLY TAPPENDEN; Fiscal Year: 2006
    ..Necrotizing enterocolitis is the most common surgical emergency among premature infants, which requires removal of the necrotic ..
  68. Xanthine oxidase inhibitor for congestive heart failure
    Alex Nivorozhkin; Fiscal Year: 2002
    ..that a prototype of this class profoundly reduces inflammation in experimental models of acute lung injury and enterocolitis. The central objective of this Phase I grant proposal is to establish in vivo proof of principle that the lead ..
  69. Recombinant Lactoferrin and Necrotizing Enterocolitis
    Karel Petrak; Fiscal Year: 2004
    ..on our hypothesis that recombinant human lactoferrin [rhLF] can prevent or reduce severity of necrotizing enterocolitis [NEC]. NEC is mainly a disease of very low birth weight [VLBW] human infants...
  70. Y ENTEROCOLITICA VIRULENCE PLASMID
    John Morris; Fiscal Year: 1991
    Yersinia enterocolitica has been implicated as a significant cause of enteritis and enterocolitis, may cause mesenteric adenitis, hepatosplenic abcesses, and septicemia. Virulence of Y...
  71. Novel Complementary Therapy for Preterm Infants
    John Bauer; Fiscal Year: 2009
    ..One of these conditions is necrotizing enterocolitis (NEC), a major cause of morbidity and mortality in neonatal intensive care units, is a disease for which there ..
  72. SURGERY FOR NEC IN HUMAN INFANTS-- A RANDOMIZED TRIAL
    R Moss; Fiscal Year: 2002
    Necrotizing enterocolitis (NEC) is a severe inflammatory disease of the intestine that occurs in premature and low birth weight infants. In its most severe form, NEC results in perforation of the bowel mandating surgical intervention...
  73. GI MYOELECTRIC ACTIVITY--MATURATION AND FUNCTION
    Joanne Szabo; Fiscal Year: 1993
    Necrotizing enterocolitis (NEC) develops in up to 7600 U.S. infants annually, is leading cause of surgical emergency in neonates, and leads to death from peritonitis and overwhelming sepsis in 28-41% of cases...
  74. Closure of the Primate Ductus Arteriosus
    Ronald Clyman; Fiscal Year: 2006
    ..dysplasia, a prolonged need for mechanical ventilation, and an increased incidence of necrotizing enterocolitis. Although inhibitors of prostaglandin synthesis, like indomethacin, induce ductus closure in 85% of preterm ..
  75. MUCOSAL PROTECTIVE FACTORS IN HUMAN MILK
    Radhakrishna Rao; Fiscal Year: 2003
    Neonatal necrotizing enterocolitis (NEC), the acute necrosis of the small intestine, is the most common non-respiratory, life-threatening disease among infants admitted to neonatal intensive care units...
  76. The Neonatal Microbiome and Necrotizing Enterocolitis
    Phillip Tarr; Fiscal Year: 2009
    DESCRIPTION: Necrotizing enterocolitis (NEC) is a devastating disorder that affects approximately 10% of premature infants. Its mortality remains high (15-30%), and its cause remains unknown...
  77. Early Enterocyte Injury in Neonatal Necrotizing Enterocolitis
    ERIKA CLAUD; Fiscal Year: 2009
    Necrotizing enterocolitis (NEC) is a life-threatening inflammatory bowel disorder of unknown cause that affects approximately 10% of premature infants born <1500gm...