dysentery

Summary

Summary: Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA; PROTOZOA; or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.

Top Publications

  1. pmc Efficiency of EPI cluster sampling for assessing diarrhoea and dysentery prevalence
    S S Yoon
    National Center for Environmental Health, Centers for Disease Control and Prevention CDC, Atlanta, GA 30341 3724, USA
    Bull World Health Organ 75:417-26. 1997
  2. ncbi Progress in the prevention and control of diarrhoeal diseases since Independence
    S K Bhattacharya
    National Institute of Cholera and Enteric Diseases, P33, CIT Road, Scheme XM, Beliagata, Kolkata 700010, West Bengal, India
    Natl Med J India 16:15-9. 2003
  3. ncbi Child dysentery in the Limpopo Valley: a cohort study of water, sanitation and hygiene risk factors
    Stephen W Gundry
    Water and Health Research Centre, University of Bristol, Bristol, BS8 1UB, UK
    J Water Health 7:259-66. 2009
  4. ncbi Cross-protection studies between respiratory and calf diarrhea and winter dysentery coronavirus strains in calves and RT-PCR and nested PCR for their detection
    K O Cho
    Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA
    Arch Virol 146:2401-19. 2001
  5. ncbi Dual enteric and respiratory tropisms of winter dysentery bovine coronavirus in calves
    S J Park
    Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea
    Arch Virol 152:1885-900. 2007
  6. ncbi A novel enteropathogenic, strongly haemolytic spirochaete isolated from pig and mallard, provisionally designated 'Brachyspira suanatina' sp. nov
    Therese Råsbäck
    Department of Clinical Sciences, Swedish University of Agricultural Sciences SLU, PO Box 7018, SE 750 07 Uppsala, Sweden
    Environ Microbiol 9:983-91. 2007
  7. ncbi Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study
    Alexander C Ford
    Department of Medicine, Division of Gastroenterology, and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 138:1727-36; quiz e12. 2010
  8. ncbi A high dietary concentration of inulin is necessary to reduce the incidence of swine dysentery in pigs experimentally challenged with Brachyspira hyodysenteriae
    Christian F Hansen
    Animal Research Institute, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia
    Br J Nutr 106:1506-13. 2011
  9. ncbi Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery
    John K Marshall
    Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada
    Gut 59:605-11. 2010
  10. ncbi Spatio-temporal stochastic modelling of Clostridium difficile
    J M Starr
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK
    J Hosp Infect 71:49-56. 2009

Detail Information

Publications225 found, 100 shown here

  1. pmc Efficiency of EPI cluster sampling for assessing diarrhoea and dysentery prevalence
    S S Yoon
    National Center for Environmental Health, Centers for Disease Control and Prevention CDC, Atlanta, GA 30341 3724, USA
    Bull World Health Organ 75:417-26. 1997
    This study examines the efficiency of EPI cluster sampling in assessing the prevalence of diarrhoea and dysentery. A computer was used to simulate fieldwork carried out by a survey taker...
  2. ncbi Progress in the prevention and control of diarrhoeal diseases since Independence
    S K Bhattacharya
    National Institute of Cholera and Enteric Diseases, P33, CIT Road, Scheme XM, Beliagata, Kolkata 700010, West Bengal, India
    Natl Med J India 16:15-9. 2003
    ..A strong political will with appropriate budgetary allocation is essential for the control of childhood diarrhoeal diseases in India, a formidable task in a country with a population of over 1 billion...
  3. ncbi Child dysentery in the Limpopo Valley: a cohort study of water, sanitation and hygiene risk factors
    Stephen W Gundry
    Water and Health Research Centre, University of Bristol, Bristol, BS8 1UB, UK
    J Water Health 7:259-66. 2009
    The objective of this cohort study was to assess risk factors for child dysentery and watery diarrhoea...
  4. ncbi Cross-protection studies between respiratory and calf diarrhea and winter dysentery coronavirus strains in calves and RT-PCR and nested PCR for their detection
    K O Cho
    Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA
    Arch Virol 146:2401-19. 2001
    ..cell culture passaged isolates of 10 bovine respiratory coronavirus (BRCV), 5 calf diarrhea (CD) and 8 winter dysentery (WD) strains of BCV, but not transmissible gastroenteritis coronavirus or bovine rotavirus...
  5. ncbi Dual enteric and respiratory tropisms of winter dysentery bovine coronavirus in calves
    S J Park
    Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea
    Arch Virol 152:1885-900. 2007
    Although winter dysentery (WD), which is caused by the bovine coronavirus (BCoV) is characterized by the sudden onset of diarrhea in many adult cattle in a herd, the pathogenesis of the WD-BCoV is not completely understood...
  6. ncbi A novel enteropathogenic, strongly haemolytic spirochaete isolated from pig and mallard, provisionally designated 'Brachyspira suanatina' sp. nov
    Therese Råsbäck
    Department of Clinical Sciences, Swedish University of Agricultural Sciences SLU, PO Box 7018, SE 750 07 Uppsala, Sweden
    Environ Microbiol 9:983-91. 2007
    ..Clinical signs and macroscopic changes consistent with swine dysentery were seen both in pigs given the atypical porcine isolate and in control pigs given the reference strain of B...
  7. ncbi Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study
    Alexander C Ford
    Department of Medicine, Division of Gastroenterology, and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 138:1727-36; quiz e12. 2010
    ..We assessed prevalence of uninvestigated dyspepsia in a cohort of individuals, some of whom were exposed to bacterial dysentery in May 2000, as well as risk factors for dyspepsia in exposed individuals.
  8. ncbi A high dietary concentration of inulin is necessary to reduce the incidence of swine dysentery in pigs experimentally challenged with Brachyspira hyodysenteriae
    Christian F Hansen
    Animal Research Institute, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia
    Br J Nutr 106:1506-13. 2011
    ..experiment to examine the effect of added dietary inulin (0, 20, 40 and 80 g/kg) on the occurrence of swine dysentery (SD) and on fermentation characteristics in the large intestine after experimental challenge with the causative ..
  9. ncbi Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery
    John K Marshall
    Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada
    Gut 59:605-11. 2010
    ....
  10. ncbi Spatio-temporal stochastic modelling of Clostridium difficile
    J M Starr
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK
    J Hosp Infect 71:49-56. 2009
    ..Simulation of different interventions indicates that for the same effect size, reducing patient susceptibility to infection is more effective in reducing the number of CDAD cases than lowering transmission rates...
  11. ncbi Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery
    John K Marshall
    Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 131:445-50; quiz 660. 2006
    ..To better define its incidence and epidemiology, a large cohort study was initiated after the contamination of a municipal water supply led to a large outbreak of acute Escherichia coli 0157:H7 and Campylobacter jejuni gastroenteritis...
  12. ncbi Minimal prophylactic concentration of dietary zinc compounds in a mouse model of swine dysentery
    P Zhang
    Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln 68583-0905, USA
    Anim Health Res Rev 2:67-74. 2001
    ..the clinicopathologic expression of Brachyspira hyodysenteriae infection in a laboratory mouse model of swine dysentery. However, this concentration impaired the body weight gain of the mice...
  13. ncbi Preferences for treatment of diarrhoea and dysentery in Kaengkhoi district, Saraburi province, Thailand
    Seksun Samosornsuk
    Thammasat Univervity, Patum thani, Thailand
    J Health Popul Nutr 22:113-8. 2004
    To estimate the proportion of cases missed in a passive surveillance study of diarrhoea and dysentery at health centres and hospitals in Kaengkhoi district, Saraburi province, Thailand, a community-based cluster survey of treatment-..
  14. ncbi Blood concentrations of amino acids, glucose and lactate during experimental swine dysentery
    R Jonasson
    Department of Clinical Sciences, Section for Comparative Physiology and Medicine, Swedish University of Agricultural Sciences, P O Box 7018, S 750 07 Uppsala, Sweden
    Res Vet Sci 82:323-31. 2007
    ..was to examine blood concentrations of amino acids, glucose and lactate in association with experimental swine dysentery. Ten pigs (approximately 23kg) were orally inoculated with Brachyspira hyodysenteriae...
  15. ncbi Immunological alterations during the clinical and recovery phases of experimental swine dysentery
    Robert Jonasson
    Department of Clinical Sciences, Section for Comparative Physiology and Medicine, Swedish University of Agricultural Sciences, S 750 07 Uppsala, Sweden
    J Med Microbiol 55:845-55. 2006
    ..changes in the systemic immune response during the incubation period and following the onset of clinical swine dysentery, including the recovery period. Ten healthy conventional pigs were inoculated with Brachyspira hyodysenteriae...
  16. ncbi Differences in lymphocyte subpopulations and cell counts before and after experimentally induced swine dysentery
    Robert Jonasson
    Department of Large Animal Clinical Sciences, Unit of Comparative Physiology and Medicine, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7018, S 750 07 Uppsala, Sweden
    J Med Microbiol 53:267-72. 2004
    ..circulating leukocytes and lymphocyte subpopulations before and immediately after experimentally induced swine dysentery. Twenty-one healthy crossbred pigs (approximately 22 kg) were orally inoculated with Brachyspira hyodysenteriae...
  17. ncbi Experimental swine dysentery: comparison between infection models
    Magdalena Jacobson
    Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden National Veterinary Institute, Uppsala, Sweden
    J Med Microbiol 53:273-80. 2004
    ..Inoculation combined with feeding of large quantities of soybean meal and group-housing induced swine dysentery in all experimental animals...
  18. ncbi Protection of pigs from swine dysentery by vaccination with recombinant BmpB, a 29.7 kDa outer-membrane lipoprotein of Brachyspira hyodysenteriae
    Tom La
    School of Veterinary and Biomedical Sciences, Division of Veterinary and Biomedical Sciences, Murdoch University, WA 6150, Australia
    Vet Microbiol 102:97-109. 2004
    Swine dysentery (SD) is an important endemic infection in many piggeries, and control can be problematic. In this study the efficacy of BmpB, a 29...
  19. ncbi Community-based cluster surveys on treatment preferences for diarrhoea, severe diarrhoea, and dysentery in children aged less than five years in two districts of Ghana
    Richard B Biritwum
    Department of Community Health, Ghana Medical School, Accra, Ghana
    J Health Popul Nutr 22:182-90. 2004
    ..Results of the study suggest that rotavirus surveillance should be guided by community studies on healthcare-use patterns. Where hospital use is low for severe diarrhoea, rotavirus surveillance should include other health facilities...
  20. ncbi A community-based cluster survey on preferences for treatment of diarrhoea and dysentery in Zhengding county, Hebei province, China
    Xuan Yi Wang
    Department of Molecular Virology, Fudan University, Shanghai, China
    J Health Popul Nutr 22:104-12. 2004
    ..The respondents indicated where they sought initial care for cases of diarrhoea or dysentery among children or adults...
  21. ncbi Experimental reproduction of winter dysentery in lactating cows using BCV -- comparison with BCV infection in milk-fed calves
    M Tråvén
    Department of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, Box 7019, S 750 07 Uppsala, Sweden
    Vet Microbiol 81:127-51. 2001
    ..the same strain of bovine coronavirus (BCV), which for the first time allows experimental reproduction of winter dysentery (WD) in seronegative lactating cows...
  22. ncbi "War dysentery" and the limitations of German military hygiene during World War I
    Derek S Linton
    Department of History, Hobart College, Geneva, NY, USA
    Bull Hist Med 84:607-39. 2010
    This article examines major epidemics of bacillary dysentery in the German army as well as among civilians in eastern Europe and in Germany during World War I...
  23. ncbi [Overdiagnosis of amebiasis in children with dysentery]
    Juan Carlos Beltramino
    Hospital de Niños Dr Orlando Alassia, Santa Fe
    Arch Argent Pediatr 107:510-4. 2009
    ..That brought the new hypothesis that many of the cases treated as amebiasis, weren't so...
  24. ncbi The patient presenting with acute dysentery--a systematic review
    Margaret L Pfeiffer
    Medical School, University of Texas, 6431 Fannin, Houston, TX 77030, USA
    J Infect 64:374-86. 2012
    The etiologies, clinical presentations and diagnosis of acute pathogen-specific dysentery in children and adults in industrialized and developing regions is described to help develop recommendations for therapy.
  25. ncbi Comparison of atypical Brachyspira spp. clinical isolates and classic strains in a mouse model of swine dysentery
    Eric Burrough
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Vet Microbiol 160:387-94. 2012
    ..presence of the strongly beta-hemolytic Brachyspira hyodysenteriae is typically associated with clinical swine dysentery. Recently, several Brachyspira spp...
  26. pmc Blood concentrations of the cytokines IL-1beta, IL-6, IL-10, TNF-alpha and IFN-gamma during experimentally induced swine dysentery
    Robert Kruse
    Department of Clinical Sciences, Section for Comparative Physiology and Medicine, Swedish University of Agricultural Sciences, P O Box 7054, S 750 07, Uppsala, Sweden
    Acta Vet Scand 50:32. 2008
    ..at infection with Brachyspira hyodysenteriae can help understanding disease mechanism involved during swine dysentery. Since this knowledge is still limited the aim of the present study was to induce dysentery experimentally in ..
  27. pmc Swine dysentery: aetiology, pathogenicity, determinants of transmission and the fight against the disease
    Avelino Alvarez-Ordóñez
    Infectious Diseases and Epidemiology Unit, University of Leon, Leon 24071, Spain
    Int J Environ Res Public Health 10:1927-47. 2013
    Swine Dysentery (SD) is a severe mucohaemorhagic enteric disease of pigs caused by Brachyspira hyodysenteriae, which has a large impact on pig production and causes important losses due to mortality and sub-optimal performance...
  28. ncbi Decreased susceptibility to tiamulin and valnemulin among Czech isolates of Brachyspira hyodysenteriae
    Dana Lobová
    Institute of Microbiology and Immunology, Section of Pathobiology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Palackeho 1 3, 612 42 Brno, Czech Republic
    J Med Microbiol 53:287-91. 2004
    ..0 and 8.0 microg ml. The increase in MICs of tiamulin and valnemulin demonstrated in this study reflect the intensity of pleuromutilin use in the treatment of swine dysentery in the Czech Republic.
  29. ncbi Randomized intervention study of solar disinfection of drinking water in the prevention of dysentery in Kenyan children aged under 5 years
    Martella Du Preez
    Natural Resources and the Environment, CSIR, P O Box 395, Pretoria, South Africa
    Environ Sci Technol 45:9315-23. 2011
    ..2007 to March 2009) investigating the effect of solar disinfection (SODIS) of drinking water on the incidence of dysentery, nondysentery diarrhea, and anthropometric measurements of height and weight among children of age 6 months to 5 ..
  30. ncbi Sensitivity of strains of Serpulina hyodysenteriae isolated in Hungary to chemotherapeutic drugs
    L Molnar
    Department of Microbiology and Infectious Diseases, University of Veterinary Science Budapest, Hungary
    Vet Rec 138:158-60. 1996
    ..between 1978 and 1992 was tested against seven chemotherapeutic drugs frequently used for the treatment of swine dysentery, and the changes in the patterns of resistance were also monitored...
  31. ncbi El Niño Southern Oscillation (ENSO) and dysentery in Shandong province, China
    Ying Zhang
    Department of Public Health, The University of Adelaide, Adelaide, SA 5005, Australia
    Environ Res 103:117-20. 2007
    To investigate the impact of the El Niño Southern Oscillation (ENSO) on dysentery transmission, the relationship between monthly dysentery cases in Shandong Province of China and the monthly Southern Oscillation Index (SOI), a broad ..
  32. ncbi Evaluation of large-intestinal parameters associated with dietary treatments designed to reduce the occurrence of swine dysentery
    Zorica Durmic
    Division of Veterinary and Biomedical Sciences, Murdoch University, WA 6150, Australia
    Br J Nutr 88:159-69. 2002
    ..and resistant starch (RS) increase hindgut fermentation in pigs, which in turn increases the incidence of swine dysentery (SD) after infection with the intestinal spirochaete Brachyspira hyodysenteriae...
  33. ncbi Susceptibility to pleuromutilins in Brachyspira (Serpulina) hyodysenteriae
    M Karlsson
    Department of Antibiotics, National Veterinary Institute, Uppsala, Sweden
    Anim Health Res Rev 2:59-65. 2001
    ..the only antimicrobial agents with sufficient minimum inhibitory concentration (MIC) values left to treat swine dysentery in Sweden...
  34. ncbi Comparison of methods for antimicrobial susceptibility testing and MIC values for pleuromutilin drugs for Brachyspira hyodysenteriae isolated in Germany
    Judith Rohde
    Department of Infectious Diseases, School of Veterinary Medicine Hannover, Institute for Microbiology, Bischofsholer Damm 15, 30173, Germany
    Vet Microbiol 102:25-32. 2004
    In Germany treatment of swine dysentery is hampered by Brachyspira hyodysenteriae strains showing elevated MIC values to the few antibiotics licensed...
  35. ncbi Enteroinvasive Escherichia coli severe dysentery complicated by rotavirus gastroenteritis
    Leova Pacheco-Gil
    Hospital del Nino, Dr Rodolfo Nieto Padrón, Villahermosa, Tabasco, Mexico
    J Infect 53:e211-3. 2006
    Enteroinvasive Escherichia coli (EIEC) is an important agent of pediatric diarrhea and dysentery in developing countries...
  36. pmc Application of Poisson kriging to the mapping of cholera and dysentery incidence in an endemic area of Bangladesh
    Mohammad Ali
    International Vaccine Institute, SNU Research Park, San 4 8 Bongcheon 7 Dong, Kwanak gu, Seoul, Korea
    Int J Health Geogr 5:45. 2006
    ..The methodology is illustrated using cholera and dysentery data collected in a cholera endemic area (Matlab) of Bangladesh.
  37. ncbi Differences in perception of dysentery and enteric fever and willingness to receive vaccines among rural residents in China
    Xinguang Chen
    Prevention Research Center, The Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, 4201 St Antoine Street UHC 6D, Detroit, MI 48201, USA
    Vaccine 24:561-71. 2006
    Enteric diseases including dysentery and enteric fever remain significant public health problems in China...
  38. ncbi Bovine coronavirus as the causative agent of winter dysentery: serological evidence
    S Alenius
    National Veterinary Institute, Swedish University of Agricultural Sciences, Uppsala
    Acta Vet Scand 32:163-70. 1991
    Sera from 9 dairy herds with epizootic enteritis (winter dysentery) were examined for antibodies to bovine coronavirus (BCV) and bovine virus diarrhoea virus (BVDV)...
  39. pmc Isolation, oxygen sensitivity, and virulence of NADH oxidase mutants of the anaerobic spirochete Brachyspira (Serpulina) hyodysenteriae, etiologic agent of swine dysentery
    T B Stanton
    National Animal Disease Center, Agricultural Research Service, Ames, Iowa 50010, USA
    Appl Environ Microbiol 65:5028-34. 1999
    Brachyspira (Serpulina) hyodysenteriae, the etiologic agent of swine dysentery, uses the enzyme NADH oxidase to consume oxygen...
  40. pmc Multiple-locus variable-number tandem-repeat analysis of the swine dysentery pathogen, Brachyspira hyodysenteriae
    Alvaro Hidalgo
    Department of Animal Health, Faculty of Veterinary Science, University of Leon, Leon 24071, Spain
    J Clin Microbiol 48:2859-65. 2010
    The spirochete Brachyspira hyodysenteriae is the causative agent of swine dysentery, a severe colonic infection of pigs that has a considerable economic impact in many swine-producing countries...
  41. ncbi Bacterial enteric pathogens in children with acute dysentery in Thailand: increasing importance of quinolone-resistant Campylobacter
    L Bodhidatta
    Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 33:752-7. 2002
    ..An etiologic study of acute bacterial dysentery was conducted in children up to 12 years of age in 2 major hospitals in and around Bangkok...
  42. ncbi Consecutive pathological and immunological alterations during experimentally induced swine dysentery - a study performed by repeated endoscopy and biopsy samplings through an intestinal cannula
    M Jacobson
    Department of Clinical Sciences, Swedish University of Agricultural Sciences, P O Box 7018, Uppsala, Sweden
    Res Vet Sci 82:287-98. 2007
    ..the development of intestinal alterations in vivo and describe the sequential events during the course of swine dysentery. The number of animals used in a study could thus be minimised and the precision of the experiment increased.
  43. ncbi Diarrheal epidemics among Rwandan refugees in 1994. Management and outcome in a field hospital
    S N Heyman
    Department of Medicine, Hadassah University Hospital, Mount Scopus, Israel
    J Clin Gastroenterol 25:595-601. 1997
    We describe the clinical course and outcome of Rwandan refugees with cholera-like illness (n = 567) and clinical dysentery (n = 1,062) treated at the Israeli Army field hospital in the disaster region of Goma, Zaire, during the summer of ..
  44. ncbi Evaluation of recombinant Bhlp29.7 as an ELISA antigen for detecting pig herds with swine dysentery
    Tom La
    School of Veterinary and Biomedical Science, Murdoch University, Perth, Western Australia 6150, Australia
    Vet Microbiol 133:98-104. 2009
    Swine dysentery (SD) results from infection of the porcine large intestine with the anaerobic intestinal spirochaete Brachyspira hyodysenteriae...
  45. pmc Antibiotics for the treatment of dysentery in children
    Beatrix S Traa
    Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Epidemiol 39:i70-4. 2010
    ..pivmecillinam are the antibiotics currently recommended by the World Health Organization (WHO) for the treatment of dysentery in children; yet there have been no reviews of the clinical effectiveness of these antibiotics in recent years.
  46. ncbi Willingness to be vaccinated against shigella and other forms of dysentery: a comparison of three regions in Asia
    Robert Pack
    Department of Community Medicine, West Virginia University School of Medicine, P O Box 9190, Morgantown, WV 26506_9190, USA
    Vaccine 24:485-94. 2006
    ..countries to examine willingness for children and adults to be vaccinated against shigellosis and other forms of dysentery. The six sites were clustered into three regions for ease of comparison...
  47. ncbi Trichuris dysentery syndrome: a common cause of chronic iron deficiency anemia in adults in an endemic area (with videos)
    Mohammad S Khuroo
    Digestive Disease Centre, Dr Khuroo s Medical Clinic, Department of Pathology, Sher e Kashmir, Institute of Medical Sciences, Soura, Srinagar, Kashmir, India
    Gastrointest Endosc 71:200-4. 2010
    There are few published reports of Trichuris dysentery syndrome (TDS) in children. The disease has not been reported in adults.
  48. ncbi In vitro antimicrobial activity of six medicinal plants traditionally used for the treatment of dysentery and diarrhoea in Democratic Republic of Congo (DRC)
    A L Otshudi
    Dept of Pharmaceutical Sciences, Vrije Universiteit Brussel, Brussels, Belgium
    Phytomedicine 7:167-72. 2000
    ..Anthraquinones were not detected in any of these plants...
  49. pmc Field study of bovine coronavirus vaccine enriched with hemagglutinating antigen for winter dysentery in dairy cows
    Keizo Takamura
    Kyoto Biken Laboratories Inc, Uji, Japan
    Can J Vet Res 66:278-81. 2002
    ..This confirms the safety and high antibody-response induced by this prototype vaccine. Therefore, this vaccine may be useful for the prevention of winter dysentery caused by bovine coronavirus infection.
  50. pmc Cost-effectiveness of zinc as adjunct therapy for acute childhood diarrhoea in developing countries
    Bjarne Robberstad
    Centre for International Health, Department of Public Health and Primary Health Care, University of Bergen, 5021 Bergen, Norway
    Bull World Health Organ 82:523-31. 2004
    ..effects and cost-effectiveness of zinc used as adjunct therapy to standard treatment of acute childhood diarrhoea, including dysentery, and to reassess the cost-effectiveness of standard case management with oral rehydration salt (ORS).
  51. pmc Detection of G12 human rotaviruses in Nepal
    Sher Bahadur Pun
    Nagasaki University, Nagasaki, Japan
    Emerg Infect Dis 13:482-4. 2007
    ..3%) tested positive for rotavirus. Reverse transcription-PCR, including a revised G12-specific primer set, identified 56 (32.9%) as G2P[4] and 39 (23.0%) as G12 with P[6], P[8], or P[4]...
  52. ncbi Bloody diarrhea in an elderly patient
    Lawrence J Brandt
    Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA
    Gastroenterology 128:157-63. 2005
  53. ncbi Prime-boost vaccine regimen confers protective immunity to human-derived enterotoxigenic Escherichia coli
    M O Lasaro
    Microbiology Department, Biomedical Science Institute, University of Sao Paulo, Av Prof Lineu Prestes 1374, Sao Paulo 05508 000, Brazil
    Vaccine 23:2430-8. 2005
    ....
  54. ncbi Complementary foods associated diarrhea
    Mini Sheth
    Department of Foods and Nutrition, Faculty of Home Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India
    Indian J Pediatr 73:61-4. 2006
    ....
  55. ncbi A status survey of common water-borne diseases in desert city Bikaner (NW Rajasthan, India)
    M M Saxena
    Laboratory of Environmental Biology, Department of Zoology, Dungar College, Bikaner 334 001
    J Commun Dis 36:53-9. 2004
    ..cent families were found to suffer from one or more common water-borne diseases including amoebiasis, diarrhoea, dysentery, jaundice and typhoid. No case of fluorosis was recorded. The highest incidence was that of diarrhoea (5...
  56. ncbi Aetiology of diarrhoea in a birth cohort of children aged 0-2 year(s) in rural Mirzapur, Bangladesh
    Khundkar Z Hasan
    Public Health Sciences Division, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000, Bangladesh
    J Health Popul Nutr 24:25-35. 2006
    ..Enterotoxigenic B. fragilis was also identified as a pathogen. Ongoing vaccine efforts focusing on Shigella, rotavirus, and ETEC would be useful...
  57. ncbi G-serotypes of group A rotaviruses in Pilsen region (Czechia)
    P Pazdiora
    Institute of Epidemiology, Medical Faculty, Charles University, 305 99 Pilsen, Czechia
    Folia Microbiol (Praha) 51:133-5. 2006
    ..6, p = 0.028). In 4 children a different serotype was demonstrated in the first and second, or in the second and third stools, respectively. No dominant serotype was found in children with nosocomial infection...
  58. pmc Emergence of human rotavirus group a genotype G9 strains, Wuhan, China
    Jihong Yang
    State Key Laboratory of Virology WIV CAS, Wuhan, People s Republic of China
    Emerg Infect Dis 13:1587-9. 2007
    ..4%). The most prevalent group A rotavirus genotype was G3P[8] (62.6%), followed by G1P[8](17.6%), G1+G3P[8](8.8%), G3P[4](6.6%), G1P[4](2.2%), and G9P[8](2.2%). The G9 strains were first detected in Wuhan...
  59. pmc Predominance of rotavirus P[4]G2 in a vaccinated population, Brazil
    Ricardo Q Gurgel
    Federal University of Sergipe, Aracaju, Brazil
    Emerg Infect Dis 13:1571-3. 2007
    ..All rotaviruses were genotype P[4]G2 with 1 mixed infection with P[NT]G9. Although virus predominance could have occurred randomly, the vaccine may be less protective against P[4]G2. Prospective surveillance is urgently needed...
  60. ncbi STEC O157 outbreak in the Netherlands, September-October 2007
    I Friesema
    Centre for Infectious Diseases Epidemiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Euro Surveill 12:E071101.1. 2007
  61. ncbi Group A rotavirus-associated diarrhea in children seeking treatment in Indonesia
    Shannon D Putnam
    U S Naval Medical Research Unit No 2, Jakarta, Indonesia
    J Clin Virol 40:289-94. 2007
    ..Globally, group A rotavirus causes significant morbidity and mortality among children. Limited data exist on the epidemiology of rotavirus disease among Indonesian children...
  62. ncbi [Physiopathology of Rotavirus diarrhea]
    M Lorrot
    Service de Pediatrie Generale, Hôpital Robert Debré 82, Boulevard Sérurier 75019 Paris, France
    Arch Pediatr 14:S145-51. 2007
    ..The overall response is weak, suggesting that NSP4 may exert both secretory and subsequent antisecretory actions, hence limiting C1- secretion...
  63. ncbi Detection of toxigenic Clostridium difficile in stool samples by real-time polymerase chain reaction for the diagnosis of C. difficile-associated diarrhea
    Lance R Peterson
    Department of Pathology and Laboratory Medicine, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Clin Infect Dis 45:1152-60. 2007
    ..Current laboratory testing lacks a single assay that is sensitive, specific, and rapid. The purpose of this work was to design and validate a sensitive and specific real-time polymerase chain reaction (PCR) diagnostic test for CDAD...
  64. ncbi STEC O157 outbreak in Iceland, September-October 2007
    G Sigmundsdottir
    Centre for Health Security and Infectious Disease Control, Directorate of Health, Reykjavik, Iceland
    Euro Surveill 12:E071101.2. 2007
  65. pmc Identification of diarrheagenic Escherichia coli isolated from infants and children in Dar es Salaam, Tanzania
    Sabrina J Moyo
    Department of Microbiology and Immunology, School of Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    BMC Infect Dis 7:92. 2007
    ..This study aimed at investigating DEC among children in Dar es Salaam aged less than five years hospitalized due to acute/persistent diarrhea...
  66. ncbi Appropriate use of empirical antibiotics in acute diarrhoea: a cross-sectional survey in southern Thailand
    Seksit Osatakul
    Department of Paediatrics, Faculty of Medicine, Prince of Songkla University, Songkla, Thailand
    Ann Trop Paediatr 27:115-22. 2007
    ..Recent information on the use of antibiotics in Thai children with acute diarrhoea is lacking...
  67. ncbi Campylobacter enteritis in Ilorin, Nigeria
    S O Samuel
    Department of Medical Microbiology and Parasitology, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
    East Afr Med J 83:478-84. 2006
    ..In Nigeria, it has been reported in the northern part of the country, extensive work has also been done in the south-west leaving behind the middle-belt of the country...
  68. ncbi [Risk factors for the occurrence of sporadic Campylobacter, Salmonella and rotavirus diarrhea in preschool children]
    J B Bellido-Blasco
    Sección de Epidemiología, Centro de Salud Pública de Castellón, Conselleria de Sanitat, Espana
    An Pediatr (Barc) 66:367-74. 2007
    ..Sporadic cases of diarrhea in preschool children are highly frequent, especially those caused by rotavirus, Campylobacter and Salmonella. The aim of this study was to identify some of the factors associated with these processes...
  69. ncbi [Examples for vaccines against diarrheal diseases--rotavirus and traveller's diarrhea]
    Herwig Kollaritsch
    Institut für Spezifische Prophylaxe und Tropenmedizin, Zentrum für Physiologie und Pathophysiologie, Medizinische Universität Wien, Kinderspitalgasse 15, Vienna, Austria
    Wien Med Wochenschr 157:102-6. 2007
    ..Both vaccines display 85-98% efficacy against severe rotavirus disease and an excellent tolerability with no difference in side reactions to the placebo controls, particularly with respect to intussusceptions...
  70. ncbi Reducing stunting among children: the potential contribution of diagnostics
    Karen A Ricci
    RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, California 90407 2138, USA
    Nature 444:29-38. 2006
  71. ncbi Vaccines against traveler's diarrhoea and rotavirus disease - a review
    Ursula Wiedermann
    Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 118:2-8. 2006
    ..With respect to increasing travel habits with infants and small children, particularly when visiting friends and relatives, vaccination against rotavirus infections will also be important in international travel...
  72. ncbi [Viral acute diarrhea: clinical and evolutive aspects]
    J P Olives
    Gastroenérologie et Nutrition, Departement de Pediatrie, Hopital des Enfants, 330 av Grande Bretagne, BP 3119, 31059 Toulouse Cedex 9, France
    Arch Pediatr 14:S152-5. 2007
    ..Rotavirus infection causes severe gastroenteritis, particularly in infants under six months of age...
  73. ncbi Probiotics and the treatment of infectious diarrhea
    Jonathan E Teitelbaum
    Monmouth Medical Center, Long Branch NJ, USA
    Pediatr Infect Dis J 24:267-8. 2005
  74. ncbi Diarrheagenic Escherichia coli infection in Baltimore, Maryland, and New Haven, Connecticut
    James P Nataro
    Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 43:402-7. 2006
    ..Diarrhea remains a common complaint among US patients who seek medical attention...
  75. ncbi Antibiotic use and health-seeking behaviour in an underprivileged area of Perú
    C Kristiansson
    Department of Public Health Science, Division of International Health IHCAR, Karolinska Institutet, Stockholm, Sweden
    Trop Med Int Health 13:434-41. 2008
    ..To describe the health-seeking behaviour and use of antibiotics in the urban community of Yurimaguas in the Amazonian area of Peru...
  76. ncbi [Epidemiological study of rotavirus diarrhea in Beijing, China - a hospital-based surveillance from 1998 - 2001]
    Zhi Li Tong
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:1100-3. 2003
    ..To provide information on epidemiology of rotavirus infection in Beijing, China...
  77. ncbi [Genotype of human calicivirus from infants with diarrhea in Guangzhou city in 2001]
    Jian Ping Xie
    Central Laboratory, Guangzhou Children s Hospital, Guangzhou 510120, China
    Zhonghua Er Ke Za Zhi 41:842-4. 2003
    ..To understand the characteristics of human calicivirus (HuCV) infection in infants with diarrhea in Guangzhou city and to study genotype of the virus...
  78. ncbi Frequency of Campylobacter jejuni in diarrhoea/dysentery in children in Rawalpindi and Islamabad
    A M Ali
    Department of Microbiology, Army Medical College and Military Hospital, Rawalpindi
    J Pak Med Assoc 53:517-20. 2003
    To determine the frequency of Campylobacter jejuni infection in children suffering from diarrhoea/dysentery in the Department of Microbiology, Army Medical College and Military Hospital, Rawalpindi, from 29 August 2002 to 29 November 2002.
  79. ncbi Effect of highly fermentable dietary fiber on the development of swine dysentery and on pig performance in a "Pure--Culture Challenge Model"
    D Baumann
    Bilkei Consulting, Dubendorf, Switzerland
    Berl Munch Tierarztl Wochenschr 115:37-42. 2002
    This study tried to evaluate the effect of highly fermentable fiber on the incidence and severity of swine dysentery (SD) after experimental oral infection with pure cultures of Brachyspira (B.) hyodysenteriae...
  80. ncbi [Molecular epidemiologic survey of rotaviruses from infants and children with diarrhea in Shanghai]
    Mei Zeng
    Children s Hospital, Fudan University, Shanghai, 200032 China
    Zhonghua Er Ke Za Zhi 42:10-5. 2004
    ..To investigate molecular epidemiologic features of rotaviruses circulating in Shanghai, China...
  81. ncbi Evaluation of the Clearview Clostridium difficile Toxin A Test and various selective culture media in comparison with the cytotoxin assay for the diagnosis of Clostridium difficile-associated diarrhoea
    Tara L Anderson
    Department of Microbiology and Infectious Diseases, Royal Hobart Hospital, Hobart, Tasmania, Australia
    Pathology 35:244-7. 2003
    ..We evaluated the performances of a commercially available toxin A enzyme immunoassay (EIA; Clearview C. difficile Toxin A Test), culture and tissue culture cytotoxin assay in the diagnosis of C. difficile-associated diarrhoea...
  82. ncbi Serologic detection of Brachyspira (Serpulina) hyodysenteriae infections
    T La
    Division of Veterinary and Biomedical Sciences, Murdoch University, Western Australia, Australia
    Anim Health Res Rev 2:45-52. 2001
    Swine dysentery (SD) caused by the intestinal spirochete Brachyspira hyodysenteriae is an economically important disease in pig-producing countries throughout the world...
  83. ncbi Further characterization of porcine Brachyspira hyodysenteriae isolates with decreased susceptibility to tiamulin
    M Karlsson
    Department of Antibiotics and Department of Bacteriology, National Veterinary Institute, SE 751 89 Uppsala, Sweden
    J Med Microbiol 53:281-5. 2004
    Brachyspira hyodysenteriae is the causative agent of swine dysentery, a severe diarrhoeal disease in pigs...
  84. ncbi [Diagnosis of swine dysentery and spirochaetal diarrhea. III. Results of cultural and biochemical differentiation of intestinal Brachyspira species by routine culture from 1997 to 1999.]
    J Verspohl
    ,
    Dtsch Tierarztl Wochenschr 108:67-9. 2001
    ..It is recommended to use special transport media for the transport of the specimen...
  85. ncbi A novel method for isolation of Brachyspira (Serpulina) hyodysenteriae from pigs with swine dysentery in Italy
    A Calderaro
    Department of Pathology and Laboratory Medicine, Section of Microbiology, University of Parma, Viale A. Gramsci, 14-43100, Parma, Italy
    Vet Microbiol 80:47-52. 2001
    Brachyspira (Serpulina) hyodysenteriae was isolated from 10 of 11 pigs with clinically suspected swine dysentery in six herds in northern Italy...
  86. ncbi Outbreak of life-threatening thiamine deficiency in infants in Israel caused by a defective soy-based formula
    Aviva Fattal-Valevski
    Institute for Child Development and Pediatric Neurology Unit, Dana Children s Hospital, Sourasky Medical Center, Tel Aviv, Israel
    Pediatrics 115:e233-8. 2005
    ..Thiamine deficiency in infants is very rare in developed countries. The aim of this study was to report the epidemiology of the outbreak and to describe the diagnosis, clinical course, and outcome of 9 affected infants in our care...
  87. ncbi Doxycycline versus doxycycline and rifampin in undifferentiated spondyloarthropathy, with special reference to chlamydia-induced arthritis. A prospective, randomized 9-month comparison
    John D Carter
    Division of Rheumatology, University of South Florida, Tampa, Florida 33612, USA
    J Rheumatol 31:1973-80. 2004
    ..HSP60 plays a key role in the chronic persistent state of Chlamydia. We conducted a prospective, randomized 9-month trial to evaluate the efficacy of doxycycline versus a combination of doxycycline and rifampin in the treatment of uSpA...
  88. ncbi A comparison of disease caused by Shigella and Campylobacter species: 24 months community based surveillance in 4 slums of Karachi, Pakistan
    Sajid Bashir Soofi
    Department of Paediatrics and Child Health, Aga Khan University, Pakistan
    J Infect Public Health 4:12-21. 2011
    ..Of 394 shigellosis patients 123 (31%) presented with dysentery in contrast to only 54 (9%) of 576 patients with Campylobacter infections (p<0.001)...
  89. ncbi Mobile genetic elements and bacterial toxinoses: the superantigen-encoding pathogenicity islands of Staphylococcus aureus
    Richard P Novick
    Departments of Microbiology and Medicine, Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Plasmid 49:93-105. 2003
    ..cholera, toxic shock, scarlet fever, exfoliative dermatitis, food poisoning, travelers' diarrhea, shigella dysentery, necrotizing pneumonia, and others...
  90. ncbi [Clinical courses and pathological findings in two gay male patients with acquired immunodeficiency syndrome infected in Japan]
    S Takamizawa
    Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo Japan
    Kansenshogaku Zasshi 64:210-7. 1990
    ..Case 1. A 39 year-old Japanese homosexual male was diagnosed as amebic dysentery complicated with liver abscess on admission. He was placed on Metronidazole with complete relief...
  91. ncbi A review of the taxonomy, ethnobotany, chemistry and pharmacology of Sutherlandia frutescens (Fabaceae)
    B E van Wyk
    Department of Botany and Plant Biotechnology, University of Johannesburg, P O Box 524, Auckland Park 2006, South Africa
    J Ethnopharmacol 119:620-9. 2008
    ..vernacular names and a wide diversity of uses, including poor appetite, indigestion, stomach complaints, dysentery, colds, influenza, kidney conditions, fever, diabetes, internal cancers, uterine troubles, liver conditions, ..
  92. ncbi Diets containing inulin but not lupins help to prevent swine dysentery in experimentally challenged pigs
    C F Hansen
    Animal Research Institute, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia
    J Anim Sci 88:3327-36. 2010
    Swine dysentery is a contagious mucohemorrhagic diarrheal disease caused by the intestinal spirochete Brachyspira hyodysenteriae that colonizes and induces inflammation of the cecum and colon...
  93. ncbi [Sensibility of Entamoeba histolytica trophozoites to ivermectin]
    Francisco Gonzalez-Salazar
    Centro de Investigaciones Biomédicas del Noreste, Instituto Mexicano del Seguro Social, Mexico
    Medicina (B Aires) 69:318-20. 2009
    ..The most frequent clinical presentation are the dysentery and the amebic liver abscess. Fifty millions of cases and more than 100...
  94. pmc Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases)
    Dibyarupa Pal
    Department of Biotechnology, Indian Institute of Technology, Kharagpur, West Bengal
    Antimicrob Agents Chemother 53:458-64. 2009
    Infections with Giardia lamblia, Entamoeba histolytica, and Trichomonas vaginalis, which cause diarrhea, dysentery, and vaginitis, respectively, are each treated with metronidazole...
  95. pmc Collateral effects of antibiotics: carbadox and metronidazole induce VSH-1 and facilitate gene transfer among Brachyspira hyodysenteriae strains
    Thaddeus B Stanton
    Pre Harvest Food Safety and Enteric Diseases Research Unit, National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, Iowa 50010, USA
    Appl Environ Microbiol 74:2950-6. 2008
    Brachyspira hyodysenteriae is an anaerobic spirochete and the etiologic agent of swine dysentery. The genome of this spirochete contains a mitomycin C-inducible, prophage-like gene transfer agent designated VSH-1...
  96. pmc Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis
    John D Carter
    University of South Florida College of Medicine, Tampa, FL 33612, USA
    Arthritis Rheum 60:1311-6. 2009
    ..The aim of the present study was to assess the prevalence of synovial Chlamydia trachomatis and Chlamydia pneumoniae infections in patients with chronic undifferentiated spondylarthritis (uSpA)...
  97. pmc Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a method for the identification of new antiamebic drugs
    T S Yong
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 93:6464-9. 1996
    The pathogenic protozoan parasite Entamoeba histolytica, the cause of amebic dysentery and amebic liver abscess, is an obligate anaerobe, and derives energy from the fermentation of glucose to ethanol with pyruvate and acetyl coenzyme A ..
  98. pmc Localization of phosphatidylinositol (3,4,5)-trisphosphate to phagosomes in entamoeba histolytica achieved using glutathione S-transferase- and green fluorescent protein-tagged lipid biosensors
    Yevgeniya A Byekova
    Department of Biological Sciences, Clemson University, Clemson, South Carolina 29634, USA
    Infect Immun 78:125-37. 2010
    Entamoeba histolytica is an intestinal protozoan parasite that causes amoebic dysentery and liver abscess...
  99. ncbi Amebae and ciliated protozoa as causal agents of waterborne zoonotic disease
    Frederick L Schuster
    California Department of Health Services, Viral and Rickettsial Disease Laboratory, 850 Marina Bay Parkway, Richmond, CA 94804, USA
    Vet Parasitol 126:91-120. 2004
    ..E. histolytica and B. coli are parasitic protozoa that cause amebic dysentery and balantidiasis, respectively...
  100. pmc Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection
    Mayuresh M Abhyankar
    Departments of Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Eukaryot Cell 7:1565-72. 2008
    The unicellular eukaryote Entamoeba histolytica is a human parasite that causes amebic dysentery and liver abscess...
  101. ncbi Molecular detection of all 34 distinct O-antigen forms of Shigella
    Yayue Li
    Tianjin Biochip Corporation, 23 HongDa Street, TEDA, Tianjin 300457, PR China
    J Med Microbiol 58:69-81. 2009
    Shigella is the cause of shigellosis or bacillary dysentery, the occurrence of which is estimated to be 165 million cases per year worldwide, resulting in 1.1 million deaths...

Research Grants62

  1. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..results in a wide variety of debilitating and often deadly diarrheal diseases including travelers'diarrhea, dysentery, and cholera...
  2. New Rapid Diagnostic Tests for Amebiasis
    JOEL F HERBEIN; Fiscal Year: 2010
    ..Intestinal amebiasis causes debilitating diarrhea and dysentery, while extraintestinal amebiasis occurs when the parasite migrates from the intestinal tract to organs ..
  3. Bangladesh Centre for Global Environmental and Occupational Health
    Dewan Shamsul Alam; Fiscal Year: 2013
    ..and morbidity in Bangladesh, some of the most common water related diseases being typhoid fever, bacillary dysentery, and diarrhea...
  4. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..invasion and intercellular spread of the bacterial pathogen Shigella flexneri, the causative agent of bacillary dysentery. S...
  5. Iron transport in Shigella and pathogenic E.coli
    Shelley M Payne; Fiscal Year: 2012
    ..to adjacent epithelial cells and the invasion and resulting host inflammatory response cause the symptoms of dysentery, a disease responsible for significant morbidity and mortality worldwide...
  6. A forward genetics screen for genes regulating phagocytosis and signaling in Enta
    Lesly A Temesvari; Fiscal Year: 2010
    Entamoeba histolytica is the causative agent of amoebic dysentery and liver abscess...
  7. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been very difficult to study...
  8. Role of lipid rafts and phosphoinositides in E. histolytica virulence
    Lesly A Temesvari; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Entamoeba histolytica is the causative agent of amoebic dysentery and liver abscess. It ranks third as a worldwide cause of morbidity and has been classified as a Category B bioterrorism agent...
  9. Development of Genetic Tools in Entamoeba histolytica
    Upinder Singh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The protozoan parasite Entamoeba histolytica causes dysentery and liver abscesses and is one of the most common causes of death from parasitic disease worldwide...
  10. Molecular Mechanisms of Modulation of N-WASP activity
    Leigh A Baxt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella sp. cause 550 million cases of diarrhea or dysentery and 1.1 million deaths annually worldwide. S...
  11. Interferon gamma-mediated restriction of Shigella flexneri replication
    Michael N Starnbach; Fiscal Year: 2013
    ..pathogen responsible for serious enteric infections, characterized by severe inflammatory bacillary dysentery. Type III-secreted effector proteins enable S...
  12. 2012 Biology of Spirochetes Gordon Research Conference
    David A Haake; Fiscal Year: 2012
    ..animal diseases, including syphilis, leptospirosis, Lyme borreliosis, relapsing fever, periodontal disease and dysentery. The discussions generated at this Gordon Research Conference will promote research contributing to improved ..
  13. Molecular signaling in Shigella dissemination
    Marcia B Goldberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella, a major etiologic agent of diarrhea, dysentery, and mortality worldwide, causes disease by invading and disseminating through the colonic mucosa. Shigella sp...
  14. MOLECULAR GENETIC ANALYSIS OF SHIGELLA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella is the causative agent of bacillary dysentery in humans and primates. Over 200 million cases are reported annually and about 650,000 persons die of shigellosis each year...
  15. Investigating Entamoeba histolytica Colonic Pathogenesis
    Upinder Singh; Fiscal Year: 2012
    ..The main disease manifestations are dysentery and liver abscesses...
  16. Manipulation of epithelial cells by Shigella
    CAMMIE LESSER; Fiscal Year: 2013
    ..provided by applicant): Shigella, NIAID category B pathogens, cause ~550 million cases of diarrhea or dysentery and 1.1 million deaths each year...
  17. Mechanisms of the Type III Secretion
    Liang Tang; Fiscal Year: 2010
    ..with host cellular processes, which then can cause diseases such as plague, typhoid fever and bacterial dysentery. More than 20 structural proteins, effector proteins, and chaperones are involved in assembly, function and ..
  18. Shigella regulation of N-WASP mediated actin assembly
    Marcia B Goldberg; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Shigella sp. cause diarrhea and dysentery by invasion and spread through the colonic mucosa. Shigella sp. are CDC/NIAID priority pathogens...
  19. Manipulation of epithelial cells by Shigella
    CAMMIE LESSER; Fiscal Year: 2012
    ..provided by applicant): Shigella, NIAID category B pathogens, cause ~550 million cases of diarrhea or dysentery and 1.1 million deaths each year...
  20. Molecular signaling in Shigella dissemination
    MARCIA GOLDBERG; Fiscal Year: 2009
    Shigella, a major etiologic agent of diarrhea, dysentery, and mortality worldwide, causes disease by invading and disseminating through the colonic mucosa. Shigella sp. are CDC/NIAID Category B priority pathogens...
  21. Phosphine-Catalyzed Annulations and Their Applications
    Ohyun Kwon; Fiscal Year: 2010
    ..highly relevant to national public health, specifically the treatment of the common cold, hypertension, amoebic dysentery, malaria, arrhythmia, and cancer...
  22. The multiple states of IpaB Shigella type III secretion
    William D Picking; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella flexneri, the causative agent of bacillary dysentery, uses a type III secretion system (T3SS) to deliver virulence proteins into host cells to promote pathogen entry into these cells...
  23. Regulation of Apical Specific Endocytosis in the C. elegans Intestine
    Barth Grant; Fiscal Year: 2010
    ..Thus this research will be relevant to nutrient uptake, fluid homeostasis and dysentery, and fetal antibody transport.
  24. SHIGA-LIKE TOXIN OF ESCHERICHIA COLI
    ALISON O BRIEN; Fiscal Year: 1991
    ..molecular levels and to determine if these have essential or accessory roles in the pathogenesis of bacillary dysentery, hemorrhagic colitis, and the hemolytic uremic syndrome...
  25. ENTAMOEBA HISTOLYTICA GENOME PROJECT
    Brendan Loftus; Fiscal Year: 2002
    ..Investigator's Abstract): Entamoeba histolytica is a protozoan parasite that causes tens of millions of cases of dysentery and liver abscess in Latin America, Africa and Asia...
  26. Lipid raft effects on Shigella type III secretion system-based interactions
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Shigella flexneri, the causative agent of bacillary dysentery, uses its type III secretion system (TTSS) as a conduit through which effector proteins are shuttled from bacterial to host cell ..
  27. Mechanisms of Shigella intercellular spread
    MARCIA GOLDBERG; Fiscal Year: 2009
    Shigella is a major cause of diarrhea, dysentery, and mortality annually worldwide. S. flexneri is a CDC/NIAID Category B priority pathogen. It causes disease by invading and spreading through the colonic mucosa...
  28. Multiple Lectin Model of the Cyst Wall of Entamoeba
    John C Samuelson; Fiscal Year: 2010
    ..Entamoeba histolytica (Eh) is a protozoan parasite that causes amebic dysentery and liver abscess...
  29. Purification of a Modified Flagellar Export Apparatus
    Jonathan L McMurry; Fiscal Year: 2012
    ..pathogenic bacteria to effect virulence, underlying many bacterial diseases such as typhoid fever and bacterial dysentery. Using Salmonella enterica as a model system, we will investigate dynamic interactions among flagellar proteins ..
  30. MECHANISM OF CARBOHYDRATE TRANSPORT IN BACTERIA
    Milton Saier; Fiscal Year: 2000
    Enteric bacteria such as Escherichia coli and Salmonella species are principal causative agents of diarrhea, dysentery, urinary tract infections, meningitis in children, septicemia, enteric fevers, an pneumonia...
  31. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2004
    ..disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been difficult to study...
  32. GORDON CONFERENCE--BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2002
    ..disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been difficult to study...
  33. INTRASPECIES VARIATION IN ENTAMOEBA HISTOLYTICA
    William Petri; Fiscal Year: 1999
    ..Entamoeba histolytica is a protozoan parasite that causes amebic dysentery and liver abscess. Virtually nothing is known about how many genetically distinct forms of E...
  34. Bacterial Pathogen Amplification & Real-Time Detection
    JACK U REN; Fiscal Year: 2003
    ..coli, Vibrio cholera, Shigella dysentery, Salmonella species, Listeria monocytogenes, Camphylobacter jejuni, and Yersinia enterocolitica will be detected ..
  35. ADHERENCE BLOCKING VACCINE FOR AMEBIASIS
    William Petri; Fiscal Year: 2003
    DESCRIPTION (adapted from the application): Entamoeba histolytica, the cause of amebic liver abscess and amebic dysentery represents a significant threat to public health worldwide...
  36. Microalgal Oral Vaccines for Control of Amebiasis
    Richard Wagner; Fiscal Year: 2004
    ..specific aim of this proposal is the development of a microalgal-based oral vaccine for the prevention of amebic dysentery in humans caused by the protozoan parasite Entamoeba histolytica...
  37. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    Steven Norris; Fiscal Year: 2000
    ..disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. As a group, these organisms have historically been difficult to study because of the lack of a system for ..
  38. Identification of E. histolytica virulence factors
    Molly Hughes; Fiscal Year: 2004
    ..Invasive infection with E. histolytica leads to dysentery, amebic colitis, and amebic liver abscess...
  39. SHIGA-LIKE TOXIN--PATHOGENESIS IN DIARRHEA AND HUS
    Arthur Donohue Rolfe; Fiscal Year: 1999
    ..Shiga and Shiga-like toxins are associated with many clinical manifestations including diarrhea, dysentery, hemorrhagic colitis, and the hemolytic uremic syndrome...
  40. MOLECULAR MECHANISMS OF BACTERIAL MEDIATED APOPTOSIS
    Claudio Basilico; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Bacillary dysentery is an acute inflammatory disease of the colon caused by the Gram negative bacteria Shigella...
  41. Genetic variability of E. histolytica in Turkey
    William Petri; Fiscal Year: 2004
    ..antigen detection based-ELISA test and amebic-specific PCR) on stool samples of patients with diarrhea, dysentery and stool samples from asymptomatic individuals. We hypothesize that E...
  42. GENETIC ANALYSIS ACID RESISTANCE IN SHIGELLA SPECIES
    Pamela Small; Fiscal Year: 1992
    DESCRIPTION (Adapted from applicant's abstract): Shigella species, the causative agents of bacillary dysentery, are unique among enteric pathogens in the low infective dose required for disease...
  43. IPAC-MEDIATED INVASION OF EPITHELIAL CELLS BY SHIGELLA
    William Picking; Fiscal Year: 2001
    ..Adapted from the applicant's abstract): Shigella are gram negative enteric pathogens that cause bacillary dysentery, a serious world-wide health threat...
  44. Structure and Function of IpaC from Shigella flexneri
    William Picking; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Shigella flexneri is a gram-negative enteric pathogen that causes bacillary dysentery (shigellosis), which continues to be an important worldwide public health problem...
  45. The molecular mechanisms for the unipolar surface expression of IcsA of Shigella
    LAREAN DENISE BRANDON; Fiscal Year: 2010
    ..are obligate intracellular pathogens and causative agents of shigellosis (a form of bacillary dysentery) that causes an estimated 1.1 million deaths worldwide per annum...
  46. Developing Tools to Study Encystation in Entamoeba Histolytica
    Upinder Singh; Fiscal Year: 2007
    ..The most common manifestations of amebic infection are colonic disease (dysentery) and liver abscesses...
  47. Inhibition of pathogen-induced NFkBmediated inflammation
    Richard Peek; Fiscal Year: 2005
    ..secretion from intestinal epithelial cells leading to mucosal inflammation and the clinical manifestations of dysentery, which can be life-threatening...
  48. Assessing Genetic Diveristy in Entamoeba Histolytica
    Upinder Singh; Fiscal Year: 2006
    ..The most common manifestations of amebic infection are colonic disease (dysentery) and liver abscesses...
  49. Campylobacter jejuni invasion genes
    GEORGE FOGG; Fiscal Year: 2006
    ..jejuni results in a disease that can range from a self-limited watery diarrhea to a bloody dysentery-type picture. This severe presentation indicates that C...
  50. APOPTOSIS IN SHIGELLA INFECTIONS
    Claudio Basilico; Fiscal Year: 2004
    Shigellae are the etiological agents of bacillary dysentery, a severe form of diarrhea that is often fatal in infants. Shigellosis is an acute inflammatory disease...
  51. Shigella IcsA Activation of Actin Assembly by N-WASP
    NOEL SAUER; Fiscal Year: 2004
    ..are bacterial pathogens that cause an estimated I million deaths and 163 million cases of diarrhea and dysentery annually worldwide, predominantly in children...
  52. A Novel Structural Approach for a Shigella Vaccine
    Susan Burgess; Fiscal Year: 2002
    ..This effort is piloted by targeting the pic gene of Shigella flexneri, important in pathogenesis of dysentery. The long-range goal is to develop a panel of structural epitopes, within a large family of pathogenic molecules,..
  53. SHIGA-LIKE TOXIN--ENDOTHELIAL CELL INTERACTIONS
    Tom Obrig; Fiscal Year: 1999
    ..Most new information on HUS has come from studies related to the E. coli Shiga-like toxin (SLT)-producing dysentery bacteria and the subsequent appearance of HUS in those individuals...
  54. SHIGELLA PATHOGENESIS RELEVANT TO PROTECTIVE IMMUNITY
    MARCIA GOLDBERG; Fiscal Year: 2003
    ..causes an estimated 650,000 deaths and 200 million cases of dysentery or diarrhea annually. No effective and safe vaccine exists...
  55. Apoptotic and non-apoptotic death responses to Shigella
    Beatrice Haimovich; Fiscal Year: 2003
    Shigella is an enteric pathogen that causes dysentery in humans. The pathogen is most often acquired by ingestion of contaminated food or water...
  56. Epidemiology of Shigellosis in the Peruvian Amazon
    Margaret Kosek; Fiscal Year: 2007
    Shigellosis is the principal cause of clinical dysentery and a frequent cause of morbidity and mortality in children in impoverished regions...
  57. Substrate Recognition of a tRNA Modifying Enzyme
    George Garcia; Fiscal Year: 2006
    ..It has been shown that TGT is required for pathogenicity of the dysentery-causing bacterium Shigella flexneri...
  58. ZINC SUPPLEMENTATION IMPACT ON CHILD MORTALITY--NEPAL
    James Tielsch; Fiscal Year: 2003
    ..The analysis will focus on comparison of rates of mortality and morbidity between treatment groups with additional analyses of subgroups to look for interaction by age, gender or baseline nutritional status. ..
  59. BALTIMORE PEDIATRIC EYE SURVEY
    James Tielsch; Fiscal Year: 2007
    ..The analysis will focus on estimating the age and race-specific prevalence of ocular disorders in this group and on assessing the association of selected risk factors with the prevalence of these disorders. ..
  60. Newborn Antiseptic Washing and Neonatal Mortality-Nepal
    James Tielsch; Fiscal Year: 2005
    ..The umbilical cord infection trial will require only one year of recruitment to obtain adequate numbers to detect a 20% in infection rates in the treatment groups. ..