appendicitis

Summary

Summary: Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.

Top Publications

  1. ncbi Appendectomy versus antibiotic treatment in acute appendicitis. a prospective multicenter randomized controlled trial
    Johan Styrud
    Department of Surgery, Karolinska Institutet at Danderyd Hospital, S 182 88, Stockholm, Sweden
    World J Surg 30:1033-7. 2006
  2. ncbi Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum
    Alexander Swidsinski
    Humboldt University, Charite Hospital, CCM, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Berlin, Germany
    Gut 60:34-40. 2011
  3. pmc Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials
    Krishna K Varadhan
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    BMJ 344:e2156. 2012
  4. ncbi Changing epidemiology of acute appendicitis in the United States: study period 1993-2008
    Michelle T Buckius
    Department of Surgery, York Hospital, York, Pennsylvania, USA
    J Surg Res 175:185-90. 2012
  5. ncbi The burden of appendicitis-related hospitalizations in the United States in 1997
    Glenn M Davies
    Merck Research Laboratories, Merck and Co Inc, Blue Bell, Pennsylvania, USA
    Surg Infect (Larchmt) 5:160-5. 2004
  6. ncbi Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease
    Adrienne van Randen
    Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Suite G1 227, 1105 AZ Amsterdam, The Netherlands
    Radiology 249:97-106. 2008
  7. ncbi Novel solutions for an old disease: diagnosis of acute appendicitis with random forest, support vector machines, and artificial neural networks
    Chung Ho Hsieh
    Institute of Biomedical Informatics, National Yang Ming University, Taipei, Taiwan
    Surgery 149:87-93. 2011
  8. ncbi Low-dose abdominal CT for evaluating suspected appendicitis
    Kyuseok Kim
    Department of Emergency Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi Do, South Korea
    N Engl J Med 366:1596-605. 2012
  9. ncbi Diagnostic value of hyperbilirubinemia as a predictive factor for appendiceal perforation in acute appendicitis
    Michael Sand
    Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr University, Bochum, Bergstr 26, 44791, Bochum, Germany
    Am J Surg 198:193-8. 2009
  10. pmc Laparoscopic versus open appendectomy: the risk of postoperative infectious complications
    Muhammad Najm Khan
    Colorectal Surgery, Royal Hampshire County Hospital, Romsey Road, Winchester, Hampshire, UK
    JSLS 11:363-7. 2007

Detail Information

Publications350 found, 100 shown here

  1. ncbi Appendectomy versus antibiotic treatment in acute appendicitis. a prospective multicenter randomized controlled trial
    Johan Styrud
    Department of Surgery, Karolinska Institutet at Danderyd Hospital, S 182 88, Stockholm, Sweden
    World J Surg 30:1033-7. 2006
    Appendectomy has been the treatment for acute appendicitis for over 120 years...
  2. ncbi Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum
    Alexander Swidsinski
    Humboldt University, Charite Hospital, CCM, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Berlin, Germany
    Gut 60:34-40. 2011
    Acute appendicitis is a local intestinal inflammation with unclear origin. The aim was to test whether bacteria in appendicitis differ in composition to bacteria found in caecal biopsies from healthy and disease controls.
  3. pmc Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials
    Krishna K Varadhan
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    BMJ 344:e2156. 2012
    To compare the safety and efficacy of antibiotic treatment versus appendicectomy for the primary treatment of uncomplicated acute appendicitis.
  4. ncbi Changing epidemiology of acute appendicitis in the United States: study period 1993-2008
    Michelle T Buckius
    Department of Surgery, York Hospital, York, Pennsylvania, USA
    J Surg Res 175:185-90. 2012
    Addis et al. [5] described the epidemiology of appendicitis in the United States from 1970 to 1984. He reported that while overall incidence decreased, the highest incidence of appendicitis occurred in 10- to 19-y-olds...
  5. ncbi The burden of appendicitis-related hospitalizations in the United States in 1997
    Glenn M Davies
    Merck Research Laboratories, Merck and Co Inc, Blue Bell, Pennsylvania, USA
    Surg Infect (Larchmt) 5:160-5. 2004
    Acute appendicitis is among the most frequent causes of surgical abdominal disease worldwide.
  6. ncbi Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease
    Adrienne van Randen
    Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Suite G1 227, 1105 AZ Amsterdam, The Netherlands
    Radiology 249:97-106. 2008
    ..comparison of graded compression ultrasonography (US) and computed tomography (CT) in helping diagnose acute appendicitis with an emphasis on diagnostic value at different disease prevalences, commonly occurring in various hospital ..
  7. ncbi Novel solutions for an old disease: diagnosis of acute appendicitis with random forest, support vector machines, and artificial neural networks
    Chung Ho Hsieh
    Institute of Biomedical Informatics, National Yang Ming University, Taipei, Taiwan
    Surgery 149:87-93. 2011
    Diagnosing acute appendicitis clinically is still difficult. We developed random forests, support vector machines, and artificial neural network models to diagnose acute appendicitis.
  8. ncbi Low-dose abdominal CT for evaluating suspected appendicitis
    Kyuseok Kim
    Department of Emergency Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi Do, South Korea
    N Engl J Med 366:1596-605. 2012
    Computed tomography (CT) has become the predominant test for diagnosing acute appendicitis in adults. In children and young adults, exposure to CT radiation is of particular concern...
  9. ncbi Diagnostic value of hyperbilirubinemia as a predictive factor for appendiceal perforation in acute appendicitis
    Michael Sand
    Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr University, Bochum, Bergstr 26, 44791, Bochum, Germany
    Am J Surg 198:193-8. 2009
    Appendiceal perforation in patients with acute appendicitis may cause a variety of potentially life-threatening complications. Escherichia coli endotoxin has been shown to impact physiological bile flow in vivo...
  10. pmc Laparoscopic versus open appendectomy: the risk of postoperative infectious complications
    Muhammad Najm Khan
    Colorectal Surgery, Royal Hampshire County Hospital, Romsey Road, Winchester, Hampshire, UK
    JSLS 11:363-7. 2007
    ....
  11. ncbi Comparison of CT and sonography in the diagnosis of acute appendicitis: a blinded prospective study
    Pieter Poortman
    Department of Surgery, St Elisabeth Hospital Tilburg, Hilvarenbeekseweg 60, 5000 LC Tilburg, The Netherlands
    AJR Am J Roentgenol 181:1355-9. 2003
    ..compare the accuracy of CT and sonography in a general community teaching hospital for the diagnosis of acute appendicitis in patients with suspected acute appendicitis. SUBJECTS AND METHODS...
  12. ncbi Surgery versus conservative antibiotic treatment in acute appendicitis: a systematic review and meta-analysis of randomized controlled trials
    Luca Ansaloni
    Unit of General Surgery, Ospedali Riuniti, Bergamo, Italy lansaloni ospedaliriuniti bergamo it
    Dig Surg 28:210-21. 2011
    ..there has recently been an increase in the use of antibiotic therapy as primary treatment for acute appendicitis (AA)...
  13. ncbi Left-sided acute appendicitis with situs inversus totalis: review of 63 published cases and report of two cases
    Sami Akbulut
    Department of Surgery, Diyarbakir Education and Research Hospital, 21400, Diyarbakir, Turkey
    J Gastrointest Surg 14:1422-8. 2010
    ..Situs inversus (SI) and midgut malrotation (MM) are uncommon anatomic anomalies that complicate diagnosis and management of acute abdominal pain...
  14. ncbi The appendicitis inflammatory response score: a tool for the diagnosis of acute appendicitis that outperforms the Alvarado score
    Manne Andersson
    Department of Surgery, County Hospital Ryhov, 551 85 Jönköping, Sweden
    World J Surg 32:1843-9. 2008
    The clinical diagnosis of appendicitis is a subjective synthesis of information from variables with ill-defined diagnostic value...
  15. ncbi Making the diagnosis of acute appendicitis: do more preoperative CT scans mean fewer negative appendectomies? A 10-year study
    Courtney A Coursey
    Department of Radiology, Duke University Medical Center, Box 3808, Erwin Road, Durham, NC 27710, USA
    Radiology 254:460-8. 2010
    ..the frequency of preoperative computed tomography (CT) in the evaluation of patients suspected of having appendicitis at one institution during the past 10 years and to determine whether changes in CT utilization were associated ..
  16. ncbi Trends in rural and urban differentials in incidence rates for ruptured appendicitis under the National Health Insurance in Taiwan
    N Huang
    Institute of Public Health, National Yang Ming University, 155 Ni Long Street, Taipei 112, Taiwan, ROC
    Public Health 120:1055-63. 2006
    ..Changes in the rates of ruptured appendicitis were compared between residents of remote and non-remote areas in Taiwan, under the National Health Insurance (..
  17. ncbi A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon)
    Constantinos Simillis
    Department of Surgical Oncology and Technology, Imperial College, London, UK
    Surgery 147:818-29. 2010
    No standardized approach is available for the management of complicated appendicitis defined as appendiceal abscess and phlegmon. This study used meta-analytic techniques to compare conservative treatment versus acute appendectomy.
  18. pmc Laparoscopic versus open appendectomy in children: a meta-analysis
    Omer Aziz
    Imperial College of Science, Technology and Medicine, Department of Surgical Oncology and Technology, St Mary s Hospital, London, UK
    Ann Surg 243:17-27. 2006
    ..This study aims to use meta-analysis to compare laparoscopic and open appendectomy in a pediatric population...
  19. ncbi A clinical decision rule to identify children at low risk for appendicitis
    Anupam B Kharbanda
    Division of Emergency Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Pediatrics 116:709-16. 2005
    Computed tomography (CT) has gained widespread acceptance in the evaluation of children with suspected appendicitis. Concern has been raised regarding the long-term effects of ionizing radiation...
  20. ncbi Open versus laparoscopic treatment for pan-peritonitis secondary to perforated appendicitis in children: a prospective analysis
    Go Miyano
    Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan
    J Laparoendosc Adv Surg Tech A 20:655-7. 2010
    Reports on laparoscopic treatment (LT) of peritonitis secondary to perforated appendicitis (PA) in children often include localized peritonitis/appendiceal mass, without specifically referring to pan-peritonitis (PP)...
  21. pmc The Alvarado score for predicting acute appendicitis: a systematic review
    Robert Ohle
    HRB Centre for Primary Care Research, Division of Population Health Sciences, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    BMC Med 9:139. 2011
    The Alvarado score can be used to stratify patients with symptoms of suspected appendicitis; the validity of the score in certain patient groups and at different cut points is still unclear...
  22. ncbi Does this child have appendicitis? A systematic review of clinical prediction rules for children with acute abdominal pain
    Dina M Kulik
    Division of Paediatric Emergency Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Clin Epidemiol 66:95-104. 2013
    To systematically identify clinical prediction rules (CPRs) for children with suspected appendicitis and compare their methodological quality and performance.
  23. ncbi Acute appendicitis: comparison of low-dose and standard-dose unenhanced multi-detector row CT
    Caroline Keyzer
    Department of Radiology, Hopital Erasme, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Radiology 232:164-72. 2004
    To prospectively compare low- and standard-dose unenhanced multi-detector row computed tomography (CT) in patients suspected of having acute appendicitis.
  24. ncbi Appendiceal diverticulitis: diagnosis and differentiation from usual acute appendicitis using computed tomography
    Kyoung Ho Lee
    Department of Radiology, Seoul National University Bundang Hospital, Seongnam si, Gyeonggi Do, Korea
    J Comput Assist Tomogr 31:763-9. 2007
    ..To describe the computed tomographic findings of appendiceal diverticulitis...
  25. ncbi Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents
    Teruhiko Terasawa
    San Francisco Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California, USA
    Ann Intern Med 141:537-46. 2004
    Although clinicians commonly use computed tomography or ultrasonography to diagnose acute appendicitis, the accuracy of these imaging tests remains unclear.
  26. pmc Bacteremia due to Clostridium hathewayi in a patient with acute appendicitis
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 42:5947-9. 2004
    ..The bacterium (strain HKU18) was isolated from the blood culture of a 39-year-old patient with acute gangrenous appendicitis complicated by septic shock. The cells were strictly anaerobic, nonmotile rods that stained gram negative...
  27. ncbi Efficacy of laparoscopic appendectomy in appendicitis with peritonitis
    Gregory J Mancini
    Department of Surgery, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Am Surg 71:1-4; discussion 4-5. 2005
    ..A retrospective nonrandomized cohort of 92 patients underwent LA for acute appendicitis with peritonitis, perforation, or abscess at our institution between 1997 and 2002...
  28. ncbi The status of appendiceal CT in an urban medical center 5 years after its introduction: experience with 753 patients
    James T Rhea
    Harvard Medical School and Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    AJR Am J Roentgenol 184:1802-8. 2005
    ..Our purpose was to determine the percentage of patients for whom CT was performed, incidence of appendicitis, accuracy of CT, percentage of equivocal interpretations, and negative appendectomy rates for those patients ..
  29. ncbi Intravascular lymphocytosis in acute appendicitis: potential mimicry of chronic lymphocytic leukaemia
    Sandra Lee
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, AB, Canada
    Histopathology 55:660-4. 2009
    ..The aim was to describe the IVL phenomenon in appendiceal specimens removed for appendicitis that can mimic chronic lymphocytic leukaemia and to investigate factors that could contribute to the ..
  30. pmc Acute appendicitis
    D J Humes
    Division of Gastrointestinal Surgery, Section of Surgery, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH
    BMJ 333:530-4. 2006
  31. ncbi Diagnosis of appendicitis with left lower quadrant pain
    Sen Kuang Hou
    Emergency Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 68:599-603. 2005
    ..chief complaints of patients presenting to the emergency department and, among the diagnoses of abdominal pain, appendicitis is the most common surgical disorder...
  32. ncbi Evidence-based adjustment of antibiotic in pediatric complicated appendicitis in the era of antibiotic resistance
    Kin Wai Edwin Chan
    Division of Paediatric Surgery and Paediatric Urology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Pediatr Surg Int 26:157-60. 2010
    ..resistant-bacteria, the traditional choice of broad spectrum antibiotics may not be effective in complicated appendicitis. We herein report the bacteriology and antibiotic susceptibility of intra-operative peritoneal culture in ..
  33. ncbi Added value of ultrasound re-evaluation for patients with equivocal CT findings of acute appendicitis: a preliminary study
    Ji Ye Sim
    Department of Radiology, Daejin Medical Center Bundang Jesaeng General Hospital, 255 2, Seohyun Dong, Bundang gu, Sungnam si, Gyeonggi do 463 774, Republic of Korea
    Eur Radiol 23:1882-90. 2013
    To prospectively estimate the additional diagnostic value of ultrasound (US) re-evaluation for patients with equivocal computed tomography (CT) findings of acute appendicitis.
  34. ncbi Non-patient factors related to rates of ruptured appendicitis
    N Sicard
    Faculte de Medecine, Departement de Medecine sociale et preventive, Universite de Montreal, and Department of Surgery, Hopital Maisonneuve Rosemont, Montreal, Quebec, Canada
    Br J Surg 94:214-21. 2007
    Adult rates of ruptured appendicitis vary from 13.2 to 41.9 per cent in urban hospitals, despite controlling for individual factors. This suggests an effect of hospital organization...
  35. ncbi Primary Kaposi's sarcoma of the appendix: a rare cause of appendicitis
    Goswin Y Meyer-Rochow
    ANZ J Surg 77:402-3. 2007
  36. ncbi Laparoscopic appendectomy is recommended for the treatment of complicated appendicitis in children
    Maria Menezes
    National Children s Hospital, Dublin, Ireland
    Pediatr Surg Int 24:303-5. 2008
    Laparoscopic appendectomy in children is well accepted for the treatment of non complicated appendicitis. An increased risk of postoperative intraabdominal abcess formation has been reported in complicated appendicitis...
  37. ncbi Ileocecal Burkitt's lymphoma presenting as ileocolic intussusception with appendiceal invagination and acute appendicitis
    Sheng Mine Wang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Formos Med Assoc 109:476-9. 2010
    ..Burkitt's lymphoma might present primarily as intussusception in children but has rarely been associated with appendicitis. We report a case in which a 10-year-old obese boy who initially presented with acute appendicitis due to ..
  38. ncbi Peritoneal fluid culture in appendicitis: review in changing times
    Huw O B Davies
    Department of Gastrointestinal Surgery, Charing Cross Hospital, Imperial College Healthcare NHS Trust, UK
    Int J Surg 8:426-9. 2010
    ..predating wider use of laparoscopic appendicectomy, increasing numbers of immunocompromised people at risk of appendicitis and the clinical/medicolegal significance of increasing risk of antibiotic-associated Clostridium difficile ..
  39. ncbi Comparison of outcomes of laparoscopic and open appendectomy in management of uncomplicated and complicated appendicitis
    Manish M Tiwari
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Ann Surg 254:927-32. 2011
    Several studies have demonstrated the superiority of the laparoscopic approach in uncomplicated and complicated appendicitis with conflicting results...
  40. ncbi Effect of race and socioeconomic status in the treatment of appendicitis in patients with equal health care access
    Steven L Lee
    Division of Pediatric Surgery, Kaiser Permanente, Los Angeles Medical Center, 4760 Sunset Blvd, Third Floor, Los Angeles, CA 90027, USA
    Arch Surg 146:156-61. 2011
    ..Lower socioeconomic and minority racial/ethnic status have been linked to delays in surgical care and thus higher appendiceal perforation rates...
  41. ncbi Diagnosis of acute appendicitis: comparison of 5- and 10-mm CT sections in the same patient
    D I Weltman
    Department of Radiology, Nassau County Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USA
    Radiology 216:172-7. 2000
    To compare 5- and 10-mm computed tomographic (CT) sections in the same patient to diagnose acute appendicitis.
  42. ncbi Bacteriology of acute appendicitis and its implication for the use of prophylactic antibiotics
    Chin Yau Chen
    Department of Surgery, National Yang Ming University Hospital, I Lan, Taiwan
    Surg Infect (Larchmt) 13:383-90. 2012
    ..The objective of this study was to reevaluate the bacteriology of acute appendicitis in order to assess the usefulness of current antibiotic prophylaxis.
  43. ncbi Comparison of intraabdominal abscess formation after laparoscopic and open appendicectomies in children
    Ramesh M Nataraja
    Department of Paediatric Surgery, Chelsea and Westminster Hospital NHS Foundation Trust, SW10 9NH London, UK
    J Pediatr Surg 47:317-21. 2012
    ..Our aim was to determine the incidence of IAA in 3 pediatric surgical centers routinely practicing both techniques...
  44. ncbi Bacteriologic epidemiology and empirical treatment of pediatric complicated appendicitis
    Christelle Guillet-Caruba
    Assistance Publique Hopitaux de Paris, Laboratoire de Microbiologie, Hopital Necker Enfants Malades, Paris 75015, France
    Diagn Microbiol Infect Dis 69:376-81. 2011
    Preoperative samples in the context of complicated appendicitis (CA) are rarely collected, and there is no consensus regarding the optimal antibiotic therapy in children...
  45. ncbi Epidemiological similarities between appendicitis and diverticulitis suggesting a common underlying pathogenesis
    Edward H Livingston
    Division of Gastrointestinal and Endocrine Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9156, USA
    Arch Surg 146:308-14. 2011
    Nonperforating appendicitis is primarily a disease of children, and nonperforating diverticulitis affects mostly older adults...
  46. ncbi Diagnostic power of inflammatory markers in predicting severity of appendicitis
    Junichi Shindoh
    Department of Surgery, Yaizu City General Hospital, Yaizu, Japan
    Hepatogastroenterology 58:2003-6. 2011
    Severity of inflammation may be a risk factor for negative outcome in non-operative therapy of appendicitis. However, optimal screening test for predicting the pathological severity of appendicitis has not been established.
  47. ncbi Laparoscopic appendectomy for acute appendicitis is more favorable for patients with comorbidities, the elderly, and those with complicated appendicitis: a nationwide population-based study
    Chun Chieh Yeh
    Trauma and Emergency Center, China Medical University Hospital, Taichung 404, Taiwan
    Surg Endosc 25:2932-42. 2011
    Laparoscopic appendectomy (LA) is not routinely performed for appendicitis because the costs associated with that procedure are higher than those for open appendectomy (OA)...
  48. ncbi Accuracies of diagnostic methods for acute appendicitis
    Jong Seob Park
    Department of Surgery, Myongji Hospital, Kwandong University, Goyang, Korea
    Am Surg 79:101-6. 2013
    ..the effectiveness of ultrasonography, computed tomography, and physical examination for diagnosing acute appendicitis with analyzing their accuracies and negative appendectomy rates in a clinical rather than research setting...
  49. ncbi Laparoscopic vs open appendectomy in children: outcomes comparison based on age, sex, and perforation status
    Steven L Lee
    Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Arch Surg 146:1118-21. 2011
    ..Outcomes of laparoscopic appendectomy (LA) will be similar to open appendectomy (OA) in children of all ages...
  50. ncbi Use of antibiotics alone for treatment of uncomplicated acute appendicitis: a systematic review and meta-analysis
    Katherine Liu
    Department of General Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Surgery 150:673-83. 2011
    The use of antibiotics alone in the treatment of uncomplicated acute appendicitis has been controversial...
  51. ncbi Diagnostic performance of multidetector computed tomography for suspected acute appendicitis
    Perry J Pickhardt
    Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 3252, USA
    Ann Intern Med 154:789-96, W-291. 2011
    Use of preoperative computed tomography for suspected acute appendicitis has dramatically increased since the introduction of multidetector CT (MDCT) scanners.
  52. ncbi Examining a common disease with unknown etiology: trends in epidemiology and surgical management of appendicitis in California, 1995-2009
    Jamie E Anderson
    Department of Surgery, Center for Surgical Systems and Public Health, University of California San Diego, 200 W Arbor Drive, San Diego, CA 92103, USA
    World J Surg 36:2787-94. 2012
    The study was designed to examine the epidemiology of appendicitis and risk factors of perforation and appendectomy.
  53. ncbi Single-incision laparoscopic appendectomy vs multiport laparoscopic appendectomy in children: a retrospective comparison
    Nicole M Chandler
    Division of Pediatric Surgery, All Children s Hospital, St Petersburg, FL 33701, USA
    J Pediatr Surg 45:2186-90. 2010
    Minimally invasive surgery is commonly used to treat appendicitis. Single-incision laparoscopic surgery is an attractive modality to treat a commonly occurring problem with the advantage of minimal or possibly no scarring...
  54. pmc Progress in the diagnosis of appendicitis: a report from Washington State's Surgical Care and Outcomes Assessment Program
    Frederick Thurston Drake
    Department of Surgery, University of Washington, 1859 NE Pacific Street, Box 356410, Seattle, WA 98195, USA
    Ann Surg 256:586-94. 2012
    Studies suggest that computed tomography and ultrasonography can effectively diagnose and rule out appendicitis, safely reducing negative appendectomies (NAs); however, some within the surgical community remain reluctant to add imaging to ..
  55. ncbi Systematic review and meta-analysis of the diagnostic accuracy of procalcitonin, C-reactive protein and white blood cell count for suspected acute appendicitis
    C W Yu
    Department of Emergency Medicine, Chang Gung Memorial Hospital, Keelung, and Chang Gung University College of Medicine, Taoyuan, Taiwan
    Br J Surg 100:322-9. 2013
    The aim was to evaluate the diagnostic value of procalcitonin, C-reactive protein (CRP) and white blood cell count (WBC) in uncomplicated or complicated appendicitis by means of a systematic review and meta-analysis.
  56. pmc Laparoscopic versus conventional appendectomy--a meta-analysis of randomized controlled trials
    Xiaohang Li
    Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
    BMC Gastroenterol 10:129. 2010
    ..open appendectomy (OA) or laparoscopic appendectomy (LA) is the most appropriate surgical approach to acute appendicitis. The purpose of this work is to compare the therapeutic effects and safety of laparoscopic and conventional "..
  57. ncbi Laparoscopic versus open appendicectomy in pregnancy: a systematic review
    Colin A Walsh
    Department of Obstetrics and Gynaecology, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 2QQ, UK, UK
    Int J Surg 6:339-44. 2008
    Acute appendicitis is the most common non-obstetric indication for surgical intervention in pregnant women. The benefits of a laparoscopic over an open approach to appendicectomy are well established in the non-pregnant population...
  58. ncbi Effect of time on risk of perforation in acute appendicitis
    B Papaziogas
    2nd Surgical Clinic, Aristotle s University of Thessaloniki Medical School, G Gennimatas General Hospital, Thessaloniki, Greece
    Acta Chir Belg 109:75-80. 2009
    ..The aim of this study was to quantify the role of time between symptom onset and surgery on the changing risk of perforation, and to evaluate the possible factors leading to delay to the operation...
  59. ncbi Transumbilical laparoscopic-assisted appendectomy (TULAA): a safe and useful alternative for uncomplicated appendicitis
    N Pappalepore
    Paediatric Surgery Unit Spirito Santo Hospital of Pescara, University of Chieti, Italy
    Eur J Pediatr Surg 12:383-6. 2002
    To compare transumbilical laparoscopic-assisted appendectomy (TULAA) and open appendectomy (OA) in cases of acute uncomplicated appendicitis.
  60. ncbi [Laparoscopic appendectomy. The new standard?]
    F Kockerling
    Klinik für Chirurgie Visceral und Gefässchirurgie, Vivantes Klinikum Spandau, Neue Bergstrasse 6, Berlin, Germany
    Chirurg 80:594-601. 2009
    ..This also holds true for specific situations such as complicated appendicitis and for morbidly obese patients...
  61. ncbi The use of white blood cell count and left shift in the diagnosis of appendicitis in children
    Linda T Wang
    Department of Pediatrics, Pediatric Emergency Medicine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Pediatr Emerg Care 23:69-76. 2007
    The use of white blood cell (WBC) count and left shift in the diagnosis of appendicitis in pediatric patients is unproven...
  62. pmc Left-sided appendicitis: review of 95 published cases and a case report
    Sami Akbulut
    Department of Surgery, Diyarbakir Education and Research Hospital, 21400 Diyarbakir, Turkey
    World J Gastroenterol 16:5598-602. 2010
    To give an overview of the literature on left-sided acute appendicitis (LSAA) associated with situs inversus totalis (SIT) and midgut malrotation (MM).
  63. pmc Does access to care affect outcomes of appendicitis in children?--A population-based cohort study
    Teresa To
    Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Health Serv Res 10:250. 2010
    ..The objective of this study is to use population-based data to measure the associations and to explain the variations of appendectomy rates with population socio-demographic indicators...
  64. ncbi Surgical validation of unenhanced helical computed tomography in acute appendicitis
    K H in't Hof
    Department of Surgery, Medical Centre Rijnmond Zuid, Rotterdam, The Netherlands
    Br J Surg 91:1641-5. 2004
    ..This prospective study assessed the accuracy of preoperative unenhanced helical computed tomography (CT) in the evaluation of patients with suspected acute appendicitis.
  65. ncbi C-reactive protein is superior to bilirubin for anticipation of perforation in acute appendicitis
    Samuel Andreas Käser
    Department of General, Visceral, Vascular and Thoracic Surgery, Hospital of Liestal, Liestal, Switzerland
    Scand J Gastroenterol 45:885-92. 2010
    Very recently it has been shown that hyperbilirubinemia is a specific predictor of perforation in acute appendicitis. We compared the diagnostic importance of bilirubin, C-reactive protein (CRP), leukocyte count and age as markers of ..
  66. ncbi Perforated appendicitis in children: equal access to care eliminates racial and socioeconomic disparities
    Steven L Lee
    Division of Pediatric Surgery, Kaiser Permanente, Los Angeles Medical Center, Los Angeles, CA 90027, USA
    J Pediatr Surg 45:1203-7. 2010
    The aim of the study was to determine whether equal access to health care eliminates racial and socioeconomic disparities in appendicitis outcomes.
  67. pmc A prospective bicenter study investigating the diagnostic value of procalcitonin in patients with acute appendicitis
    Michael Sand
    Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital, Ruhr University Bochum, Bochum, Germany
    Eur Surg Res 43:291-7. 2009
    ..However, whether or not PCT has any diagnostic value for acute appendicitis, still remains unclear...
  68. ncbi Do normal leucocyte count and C-reactive protein value exclude acute appendicitis in children?
    J M Gronroos
    Department of Surgery University of Turku, Finland
    Acta Paediatr 90:649-51. 2001
    ..to determine the role of leucocyte count and C-reactive protein (CRP) measurements in the diagnosis of acute appendicitis in children...
  69. ncbi [Is procalcitonin able to help in pediatric appendicitis diagnosis?]
    D B Kouame
    Service de chirurgie pédiatrique viscérale, urologique, plastique et brûlés, service du Professeur Michel Robert, centre de pédiatrie Gatien de Clocheville, CHU de Tours, 49 bis, Boulevard Béranger, 37044 Tours, France
    Ann Chir 130:169-74. 2005
    b>Appendicitis clinical diagnosis in children is difficult and the acute inflammatory markers hyperleucocytis and CRP do not contribute to it.
  70. ncbi Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial
    Corinne Vons
    Hôpital Antoine Béclère Assistance Publique Hôpitaux de Paris and Université Paris XI, Services de Chirurgie, Clamart, France
    Lancet 377:1573-9. 2011
    Researchers have suggested that antibiotics could cure acute appendicitis. We assessed the efficacy of amoxicillin plus clavulanic acid by comparison with emergency appendicectomy for treatment of patients with uncomplicated acute ..
  71. ncbi Meta-analysis of randomized trials comparing antibiotic therapy with appendectomy for acute uncomplicated (no abscess or phlegmon) appendicitis
    Rodney J Mason
    Division of General and Laparoscopic Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Surg Infect (Larchmt) 13:74-84. 2012
    The objective was to conduct a meta-analysis of randomized controlled trials evaluating the efficacy and morbidity of the management of acute uncomplicated (no abscess or phlegmon) appendicitis by antibiotics versus appendectomy.
  72. ncbi The role of white cell count and C-reactive protein in the diagnosis of acute appendicitis
    M N Khan
    Department of General Surgery, Wishaw General Hospital, Wishaw, Lanarkshire, UK
    J Ayub Med Coll Abbottabad 16:17-9. 2004
    Despite recent advances in diagnostic medicine, the diagnosis of appendicitis is still doubtful in a number of cases. Majority of the clinicians rely on their clinical examination strengthened by the laboratory tests...
  73. pmc Clinical analysis of the related factors in acute appendicitis
    Kim Choy Ng
    Department of Emergency Medicine, China Medical College Hospital, Taichung City, Taiwan
    Yale J Biol Med 75:41-5. 2002
    In order to determine reliable clues for early diagnosis of acute appendicitis, this study was conducted to examine the related factors in patients with clinically suspected acute appendicitis.
  74. ncbi Incarcerated vermiform appendix in a left-sided inguinal hernia
    S Breitenstein
    Department of Surgery, Kantonsspital Winterthur, 8401 Winterthur, Switzerland
    Hernia 9:100-2. 2005
    ..The possibility of the presence of a situs inversus, or malrotation, as an underlying cause for the observed pathology was excluded by x-ray examination...
  75. pmc Appendicitis during pregnancy
    Rachelle Guttman
    Motherisk Program, Hospital for Sick Children, Toronto
    Can Fam Physician 50:355-7. 2004
    ..in our clinic, who was 18 weeks pregnant at the time, experienced acute abdominal pain and was diagnosed with appendicitis. The inflamed appendix was successfully removed...
  76. ncbi Serum and peritoneal inflammatory mediators in children with suspected acute appendicitis
    Ilan Dalal
    Pediatric Infectious Allergy Immunology Unit, The E Wolfson Medical Center, Holon, Israel
    Arch Surg 140:169-73. 2005
    Inflammatory markers differ between subjects with appendicitis and controls. Markers of inflammation differ in serum compared with intraperitoneal fluid...
  77. ncbi Negative appendicectomy and perforation rates in patients undergoing laparoscopic surgery for suspected appendicitis
    U Guller
    Department of Surgery, Division of Visceral Surgery and Transplantation, University of Berne, Berne, Switzerland
    Br J Surg 98:589-95. 2011
    ..technologies including ultrasonography and computed tomography, rates of negative appendicectomy and perforated appendicitis remain high...
  78. ncbi Laparoscopic versus open appendectomy in complicated appendicitis: a review of the NSQIP database
    Karleena Regina Marie Tuggle
    Howard University Hospital, Division of Minimally Invasive and Bariatric Surgery, Washington, DC 20060, USA
    J Surg Res 163:225-8. 2010
    Laparoscopic appendectomy (LA) has been an established treatment method for uncomplicated acute appendicitis. Controversy still exits regarding the superiority of either laparoscopic or open technique for the treatment of complicated ..
  79. ncbi The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study
    L W Lamps
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Am J Surg Pathol 25:508-15. 2001
    Granulomatous appendicitis is an enigmatic entity. Purported causes include Crohn's disease, foreign body reactions, sarcoidosis, and infectious agents; however, most cases remain idiopathic. Yersinia enterocolitica (YE) and Y...
  80. ncbi Hem-o-lok plastic clips in securing of the base of the appendix during laparoscopic appendectomy
    Samir Delibegovic
    Department of Surgery, University Clinic Center, Tuzla, Bosnia and Herzegovina
    Surg Endosc 23:2851-4. 2009
    ..The objective of this study was to evaluate the technical feasibility and eventual advantages of this way of securing of the base of the appendix...
  81. ncbi Serum amyloid A protein levels as a possible aid in the diagnosis of acute appendicitis in children
    Lilia Lycopoulou
    First Department of Pediatrics, Athens University, Athens, Greece
    Clin Chem Lab Med 43:49-53. 2005
    ..count (WBC), C-reactive protein (CRP) and other acute-phase reactants, have been used in the diagnosis of acute appendicitis. However, there is controversy among physicians about the value of this practice in children...
  82. ncbi Comparison of the levels of accuracy of an artificial neural network model and a logistic regression model for the diagnosis of acute appendicitis
    Shinya Sakai
    Division of Information Science and Biostatistics, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori 1 754, Niigata 951 8520, Japan
    J Med Syst 31:357-64. 2007
    An accurate diagnosis of acute appendicitis in the early stage is often difficult, and decision support tools to improve such a diagnosis might be required...
  83. ncbi Acute appendicitis in the elderly patient: diagnostic problems, prognostic factors and outcomes
    Sorinel Lunca
    Emergency Surgical Clinic, University of Medicine and Pharmacy Gr T Popa Iasi, Romania
    Rom J Gastroenterol 13:299-303. 2004
    Acute appendicitis (AA) in the elderly (over 60 year-old) continues to pose diagnostic problems and carries a high morbidity and mortality rate...
  84. pmc The epidemiology of appendicitis and appendectomy in South Korea: national registry data
    Jung Hun Lee
    Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Epidemiol 20:97-105. 2010
    b>Appendicitis is one of the most frequent acute surgical conditions of the abdomen, and appendectomy is one of the most commonly performed operations in the world...
  85. ncbi Intra-abdominal infections
    John E Mazuski
    Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110 1093, USA
    Surg Clin North Am 89:421-37, ix. 2009
    ..Overall, these infections remain associated with significant morbidity and mortality, particularly in higher-risk patients who have impaired host defenses...
  86. ncbi Watchful waiting versus interval appendectomy for patients who recovered from acute appendicitis with tumor formation: a cost-effectiveness analysis
    Hung Wen Lai
    Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    J Chin Med Assoc 68:431-4. 2005
    Interval appendectomy after conservative treatment of appendicitis with tumor formation remains controversial. The purpose of this study was to evaluate the efficacy of interval appendectomy based on a cost-effectiveness analysis.
  87. ncbi Morbidity of laparoscopic surgery for complicated appendicitis: an international study
    J Cueto
    Department of Surgery, Hospitals ABC y Angeles Lomas, Mexico City, Mexico
    Surg Endosc 20:717-20. 2006
    ..Although laparoscopic appendectomy has some advantages over open appendectomy, some reports do show more postoperative intraabdominal abscesses...
  88. ncbi A rare pathological trinity: an appendiceal ectopic pregnancy, acute appendicitis and a carcinoid tumour
    R J Thompson
    Mid Ulster Hospital, 59 Hospital Road, Magherafelt BT45 5EX, UK
    Ir J Med Sci 180:579-80. 2011
    We present a case of a 27-year-old woman who was found to have an appendiceal ectopic pregnancy, a carcinoid tumour of the appendix and acute appendicitis existing concurrently. This triad of pathology has never been reported previously.
  89. ncbi Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients
    J Hansson
    Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
    Br J Surg 96:473-81. 2009
    A trial in selected men suggested that antibiotic therapy could be an alternative to appendicectomy in appendicitis. This study aimed to evaluate antibiotic therapy in unselected men and women with acute appendicitis.
  90. ncbi Transumbilical laparoscopic appendectomy for acute appendicitis: a reliable one-port procedure
    Shin Yi Lee
    Department of Pediatric Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Song Hsiang, Kaohsiung Hsien, Taiwan
    Surg Endosc 25:1115-20. 2011
    ..This report aims to describe a safe, effective, transumbilical, one-port laparoscopic technique for appendectomy that can be performed by one surgeon...
  91. ncbi Laparoscopic versus open appendectomy in adults with complicated appendicitis: systematic review and meta-analysis
    Georgios Markides
    Department of General Surgery, Royal Oldham Hospital, Oldham, UK
    World J Surg 34:2026-40. 2010
    The goal of the present study was to critically review and identify the strength of available evidence in the literature on the use of laparoscopic appendectomy (LA) in complicated appendicitis (CA).
  92. pmc Acute myelogenous leukemia and acute leukemic appendicitis: a case report
    Po Jen Hsiao
    Division of Nephrology, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taiwan, China
    World J Gastroenterol 15:5624-5. 2009
    ..We report a male patient who had 1 year partial remission from AML and who presented with apparent acute appendicitis as the initial manifestation of leukemia relapse...
  93. ncbi Diagnosing pediatric appendicitis: usefulness of laboratory markers
    Karen Y Kwan
    Division of Emergency and Transport Medicine, Department of Pediatrics, Children s Hospital Los Angeles, University of Southern California and the Keck School of Medicine, Los Angeles, CA 90027, USA
    Am J Emerg Med 28:1009-15. 2010
    This study aimed to evaluate the utility of C-reactive protein (CRP), procalcitonin (PCT), D-lactate, and white blood cell (WBC) count as an aid to distinguish appendicitis from other diagnoses.
  94. ncbi Decreased use of computed tomography with a modified clinical scoring system in diagnosis of pediatric acute appendicitis
    Amy Rezak
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arch Surg 146:64-7. 2011
    Use of a modified clinical grading score improves accuracy in diagnosing acute appendicitis in the pediatric population while decreasing the use of computed tomography (CT).
  95. ncbi Alvarado score as an admission criterion in children with pain in right iliac fossa
    Khalid S Shreef
    Department of Pediatric Surgery, Zagazig University, Egypt
    Afr J Paediatr Surg 7:163-5. 2010
    Acute appendicitis is an important differential diagnosis in children with pain in the right iliac fossa. Some patients have equivocal signs that make the diagnosis difficult...
  96. ncbi Evaluation of the Alvarado score in the diagnosis of acute appendicitis
    U K Shrivastava
    Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi 110095
    Trop Gastroenterol 25:184-6. 2004
    Acute appendicitis may simulate many other acute abdominal illnesses and the exact diagnosis is important for the proper management...
  97. ncbi A new approach to accurate diagnosis of acute appendicitis
    Nikolaos E Tzanakis
    Fourth Surgical Clinic, Athens University, Medical School, General State Hospital of Nikea, 3 D Mantouvalou str, Piraeus 18454, Greece
    World J Surg 29:1151-6, discussion 1157. 2005
    ..ultrasound (US) examination and clinical or laboratory predictors for increasing diagnostic accuracy in acute appendicitis (AA), and (2) to evaluate the performance of the scoring system as compared to that of previous models...
  98. ncbi Prospective validation of two systems of classification for the diagnosis of acute appendicitis
    Alexandre Escribá
    Sección de Urgencias, Servicio de Pediatria, Hospital Universitari Sant Joan de Deu, Barcelona, Spain
    Pediatr Emerg Care 27:165-9. 2011
    The objectives of this study were (1) to validate the Alvarado score and pediatric appendicitis score (PAS) in a prospectively identified pediatric cohort and (2) to assess abdominal ultrasonography (AUS) as a tool to increase the ..
  99. ncbi Negative appendectomy and imaging accuracy in the Washington State Surgical Care and Outcomes Assessment Program
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA, USA
    Ann Surg 248:557-63. 2008
    ..The Surgical Care and Outcomes Assessment Program (SCOAP) gathers chart-abstracted process of care data (such as CT/US accuracy) for general surgical procedures (including appendectomy) at most Washington State hospitals...
  100. ncbi Artificial neural networks: useful aid in diagnosing acute appendicitis
    S G Prabhudesai
    Department of Biosurgery and Surgical Technology, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, Room 1029, 10th Floor QEQM Building, Praed Street, London, W2 1NY, UK
    World J Surg 32:305-9; discussion 310-1. 2008
    ..The purpose of the study was to assess the role of artificial neural networks (ANNs) in the diagnosis of appendicitis in patients presenting with acute right iliac fossa (RIF) pain and comparing its performance with the ..
  101. ncbi Successful laparoscopic treatment of hemorrhage from the appendix with phlegmonous acute appendicitis: a case report and review of the literature
    Kimiyasu Yamazaki
    Department of Surgery, Division of General and Gastroenterological Surgery, Showa University, School of Medicine, Tokyo, Japan
    Gastrointest Endosc 63:877-80. 2006

Research Grants25

  1. ROLE OF B.FRAGILIS OXYGEN STRESS RESPONSE IN INFECTION
    Charles J Smith; Fiscal Year: 2013
    ..Intra-abdominal abscesses are formed following perforation of the bowel often due to appendicitis, diverticulitis, carcinoma, or surgery...
  2. ROLE OF B.FRAGILIS OXYGEN STRESS RESPONSE IN INFECTION
    Charles Smith; Fiscal Year: 2009
    ..Intra-abdominal abscesses are formed following perforation of the bowel often due to appendicitis, diverticulitis, carcinoma, or surgery...
  3. Gastrointestinal Surgery Outcomes Research Fellowship
    David R Flum; Fiscal Year: 2013
    ..that the vast scope of clinical issues most commonly managed by general surgeons involve digestive disease (appendicitis, biliary disease, bowel obstruction, diverticulitis, Crohn's disease, pancreatitis, etc...
  4. Genetics of Survival of Yersinia pseudotuberculosis
    Joan Mecsas; Fiscal Year: 2002
    ..enteric bacterial pathogen that causes gastroenteritis, mesenteric lymphadenitis, which can be misdiagnosed as appendicitis leading to unnecessary surgery, and occasionally systemic disease in humans and other mammals...
  5. ASSESSING THE VARIABILITY IN TIME TO TREATMENT IN SURGER
    Mark Chassin; Fiscal Year: 2001
    ..We propose to study three delay-sensitive conditions: appendicitis, ectopic pregnancy, and intestinal obstruction...
  6. ED Staffing and Patient Outcomes
    Nina Bickell; Fiscal Year: 2002
    ..and nurse staffing on time to treatment and patients' health outcomes for 3 delay sensitive conditions: appendicitis, ectopic pregnancy and intestinal obstruction...
  7. NOVEL 99MTC-TUFTSIN FOR IMAGING INFLAMMATION FOCI
    SHUBH SHARMA; Fiscal Year: 2000
    ..nuclear medicine for rapid imaging of suspected sites of infection and inflammation, including diagnosis of fevers of unknown origin, appendicitis, prosthetic infections, osteomyelitis, and opportunistic infections.
  8. REGIONAL VARIATION IN PEDIATRIC HOSPITALIZATION
    James Perrin; Fiscal Year: 1993
    ..These conditions include asthma/lower respiratory disease, meningitis, head trauma, abdominal pain/appendicitis and toxic ingestions...
  9. EXPERIMENTAL PATHOLOGY SHARED RESOURCE LABORATORY
    Laura Lamps; Fiscal Year: 2003
    ..abstract_text> ..
  10. REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMA
    Joseph Solomkin; Fiscal Year: 2004
    ..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..
  11. Surgical Care and Outcomes Assessment Program Comparative Effectiveness Research
    David R Flum; Fiscal Year: 2010
    ..Surgical and interventional services span the continuum of healthcare conditions and SCOAP CERTN will have immediate capacity for investigators interested in almost any of AHRQ's priority conditions. ..
  12. Bariatric Surgery Outcome/Cost in Medicare Beneficiaries
    David Flum; Fiscal Year: 2006
    ..3. Perform a modeled cost effectiveness analysis of bariatric procedures compared to non-surgical approaches. ..
  13. Role of Bacteroides fragilis new hemolysins in experimental infection.
    EDSON ROCHA; Fiscal Year: 2008
    ..fragilis hemolysins.] A) We will complete the initial analysis of the hemolytic/cytolytic activity of B. fragilis hemolysins. B) We will complete the construction of hemolysin mutants. [unreadable] [unreadable] [unreadable]..
  14. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  15. Heavy Drinking & Coronary Disease: Acute/Chronic Effects
    Kenneth Mukamal; Fiscal Year: 2006
    ..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
  16. ENHANCED EVALUATION OF FETAL CNS WITH ULTRAFAST MRI
    Deborah Levine; Fiscal Year: 2002
    ..Thus the results of this study could significantly decrease morbidity of fetuses with ventriculomegaly. ..
  17. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  18. MID ATLANTIC PROSTATE CANCER BANK
    Jan Orenstein; Fiscal Year: 2004
    ..This resource will assure that investigators will obtain optimal research specimens with clinical-pathologic correlation for their studies. ..
  19. MRI of Fetal Ventriculomegaly: Morphology and Outcome
    Deborah Levine; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  20. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  21. Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial Disease
    Kenneth Jay Mukamal; Fiscal Year: 2010
    ..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
  22. ENTERIC PHYSIOLOGY OF THE TRANSPLANTED GUT
    Michael Sarr; Fiscal Year: 2007
    ..This proposal will define important, novel neural mechanisms regulating motor and absorptive function in the denervated gut. Selected aspects have translational value to clinical gut transplantation. [unreadable] [unreadable]..
  23. Antiangiogenic therapy of pancreatic cancer
    Sareh Parangi; Fiscal Year: 2006
    ..This unique combination will allow me to complete the first phase of my career development and progress on to independent research. ..
  24. P53 AND DNA PLOIDY IN BARRETT'S METAPLASIA
    Mamoun Younes; Fiscal Year: 2005
    ..A cost analysis will be then performed to determine whether a molecular based surveillance program would be more cost-effective than current program which is based on morphologic grading of dysplasia. ..
  25. Epidemiology of HIV-1/HIV-2 Dual Infection
    Geoffrey Gottlieb; Fiscal Year: 2005
    ....