gastroenteritis

Summary

Summary: INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.

Top Publications

  1. ncbi Norovirus illness is a global problem: emergence and spread of norovirus GII.4 variants, 2001-2007
    J Joukje Siebenga
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 200:802-12. 2009
  2. ncbi The global burden of nontyphoidal Salmonella gastroenteritis
    Shannon E Majowicz
    Center for Food borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada
    Clin Infect Dis 50:882-9. 2010
  3. pmc Systematic literature review of role of noroviruses in sporadic gastroenteritis
    Manish M Patel
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 14:1224-31. 2008
  4. pmc Global illness and deaths caused by rotavirus disease in children
    Umesh D Parashar
    Viral Gastroenteritis Section, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop G04, Atlanta, GA 30333, USA
    Emerg Infect Dis 9:565-72. 2003
  5. ncbi Norovirus and medically attended gastroenteritis in U.S. children
    Daniel C Payne
    Epidemiology Branch, Division of Viral Diseases, National Center for Immunizations and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 368:1121-30. 2013
  6. ncbi Effect of human rotavirus vaccine on severe diarrhea in African infants
    Shabir A Madhi
    Department of Science and Technology National Research Foundation Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
    N Engl J Med 362:289-98. 2010
  7. pmc Foodborne illness acquired in the United States--unspecified agents
    Elaine Scallan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:16-22. 2011
  8. pmc Food-related illness and death in the United States
    P S Mead
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 5:607-25. 1999
  9. ncbi Clinical and molecular epidemiology of norovirus infection in childhood diarrhea in China
    Mei Zeng
    Department of Infectious Diseases and Research Laboratory of Infectious Diseases, Children s Hospital of Fudan University, Shanghai, China
    J Med Virol 84:145-51. 2012
  10. pmc Immunogenetic mechanisms driving norovirus GII.4 antigenic variation
    Lisa C Lindesmith
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 8:e1002705. 2012

Detail Information

Publications348 found, 100 shown here

  1. ncbi Norovirus illness is a global problem: emergence and spread of norovirus GII.4 variants, 2001-2007
    J Joukje Siebenga
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Infect Dis 200:802-12. 2009
    Noroviruses (NoVs) are the most common cause of viral gastroenteritis. Their high incidence and importance in health care facilities result in a great impact on public health...
  2. ncbi The global burden of nontyphoidal Salmonella gastroenteritis
    Shannon E Majowicz
    Center for Food borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada
    Clin Infect Dis 50:882-9. 2010
    To estimate the global burden of nontyphoidal Salmonella gastroenteritis, we synthesized existing data from laboratory-based surveillance and special studies, with a hierarchical preference to (1) prospective population-based studies, (2)..
  3. pmc Systematic literature review of role of noroviruses in sporadic gastroenteritis
    Manish M Patel
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 14:1224-31. 2008
    ..NoVs accounted for 12%(95% confidence interval [CI] 10%-15%) of severe gastroenteritis cases among children <5 years of age and 12% (95% CI 9%-15%) of mild and moderate diarrhea cases among ..
  4. pmc Global illness and deaths caused by rotavirus disease in children
    Umesh D Parashar
    Viral Gastroenteritis Section, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop G04, Atlanta, GA 30333, USA
    Emerg Infect Dis 9:565-72. 2003
    ..Each year, rotavirus causes approximately 111 million episodes of gastroenteritis requiring only home care, 25 million clinic visits, 2 million hospitalizations, and 352,000-592,000 deaths (..
  5. ncbi Norovirus and medically attended gastroenteritis in U.S. children
    Daniel C Payne
    Epidemiology Branch, Division of Viral Diseases, National Center for Immunizations and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 368:1121-30. 2013
    Cases of rotavirus-associated acute gastroenteritis have declined since the introduction of rotavirus vaccines, but the burden of norovirus-associated acute gastroenteritis in children remains to be assessed.
  6. ncbi Effect of human rotavirus vaccine on severe diarrhea in African infants
    Shabir A Madhi
    Department of Science and Technology National Research Foundation Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
    N Engl J Med 362:289-98. 2010
    Rotavirus is the most common cause of severe gastroenteritis among young children worldwide. Data are needed to assess the efficacy of the rotavirus vaccine in African children.
  7. pmc Foodborne illness acquired in the United States--unspecified agents
    Elaine Scallan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:16-22. 2011
    ..hospital records, and death certificates to estimate illnesses, hospitalizations, and deaths from acute gastroenteritis and subtracted illnesses caused by known gastroenteritis pathogens...
  8. pmc Food-related illness and death in the United States
    P S Mead
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 5:607-25. 1999
    ..Overall, foodborne diseases appear to cause more illnesses but fewer deaths than previously estimated...
  9. ncbi Clinical and molecular epidemiology of norovirus infection in childhood diarrhea in China
    Mei Zeng
    Department of Infectious Diseases and Research Laboratory of Infectious Diseases, Children s Hospital of Fudan University, Shanghai, China
    J Med Virol 84:145-51. 2012
    ..The results show that NoV GII.4 2006b was the predominant strain circulating in China between 2008 and 2009...
  10. pmc Immunogenetic mechanisms driving norovirus GII.4 antigenic variation
    Lisa C Lindesmith
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 8:e1002705. 2012
    Noroviruses are the principal cause of epidemic gastroenteritis worldwide with GII.4 strains accounting for 80% of infections. The major capsid protein of GII...
  11. pmc Broadly reactive and highly sensitive assay for Norwalk-like viruses based on real-time quantitative reverse transcription-PCR
    Tsutomu Kageyama
    Section of Infectious Disease, R and D Center, BML, Kawagoe, Saitama 350 1101, Japan
    J Clin Microbiol 41:1548-57. 2003
    ..We isolated virus from 71 NLV-positive stool specimens from 37 outbreaks of nonbacterial acute gastroenteritis and sequenced the open reading frame 1 (ORF1)-ORF2 junction region, the most conserved region of the NLV ..
  12. pmc Norovirus vaccine against experimental human Norwalk Virus illness
    Robert L Atmar
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 365:2178-87. 2011
    Noroviruses cause epidemic and sporadic acute gastroenteritis. No vaccine is available to prevent norovirus illness or infection.
  13. ncbi Campylobacter jejuni Infections: update on emerging issues and trends
    B M Allos
    Department of Preventive Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Clin Infect Dis 32:1201-6. 2001
    Infection with Campylobacter jejuni is one of the most common causes of gastroenteritis worldwide; it occurs more frequently than do infections caused by Salmonella species, Shigella species, or Escherichia coli O157:H7...
  14. pmc Novel surveillance network for norovirus gastroenteritis outbreaks, United States
    Everardo Vega
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:1389-95. 2011
    ..4 New Orleans, which first emerged in October 2009. Analysis of the complete capsid and P2 region sequences confirmed that GII.4 New Orleans is distinct from previous GII.4 variants, including GII.4 Minerva (2006b)...
  15. ncbi Environmental transmission of norovirus gastroenteritis
    Ben Lopman
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States
    Curr Opin Virol 2:96-102. 2012
    ..common cause of community-acquired diarrheal disease across all ages, the most common cause of outbreaks of gastroenteritis, and the most common cause of foodborne disease in the United States...
  16. ncbi The roles of Clostridium difficile and norovirus among gastroenteritis-associated deaths in the United States, 1999-2007
    Aron J Hall
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
    Clin Infect Dis 55:216-23. 2012
    Globally, gastroenteritis is recognized as an important contributor to mortality among children, but population-based data on gastroenteritis deaths among adults and the contributions of specific pathogens are limited...
  17. ncbi Genogroup-specific PCR primers for detection of Norwalk-like viruses
    Shigeyuki Kojima
    Section of Infectious Disease, R and D Center, BML, 1361 1, Matoba, Kawagoe, Saitama 350 1101, Japan
    J Virol Methods 100:107-14. 2002
    Norwalk-like viruses (NLV) are a major causative agent of nonbacterial gastroenteritis. There are still many NLV strains that are refractory to gene amplification by ordinary reverse transcription-polymerase chain reaction...
  18. pmc Molecular epidemiology of genogroup II-genotype 4 noroviruses in the United States between 1994 and 2006
    Du Ping Zheng
    Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 48:168-77. 2010
    ..4) are the most common strains detected in outbreaks of acute gastroenteritis worldwide. To gain insight into the epidemiology and genetic variation of GII...
  19. ncbi Active, population-based surveillance for severe rotavirus gastroenteritis in children in the United States
    Daniel C Payne
    Epidemiology Branch, Division of Viral Diseases, National Center for Immunizations and Respiratory Disease, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS A34, Atlanta, GA 30333, USA
    Pediatrics 122:1235-43. 2008
    ..Centers for Disease Control and Prevention New Vaccine Surveillance Network to begin population-based acute gastroenteritis surveillance among US children<3 years of age...
  20. ncbi Reduction in rotavirus-associated acute gastroenteritis following introduction of rotavirus vaccine into Australia's National Childhood vaccine schedule
    Jim P Buttery
    Department of General Medicine and Murdoch Children s Research Institute, Royal Children s Hospital Melbourne, Parkville, Victoria, Australia Paediatric Infectious Diseases Unit, Monash Children s Hospital, Department of Paediatrics, Monash University, Melbourne, Victoria
    Pediatr Infect Dis J 30:S25-9. 2011
    ..This allowed comparison of both vaccines in similar populations with high infant vaccination coverage...
  21. ncbi Emergence of the GII4/2006b variant and recombinant noroviruses in China
    Miao Jin
    National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China
    J Med Virol 80:1997-2004. 2008
    Noroviruses are an important cause of acute gastroenteritis. Increasing data showed that the GII-4 strains are predominant worldwide and new GII-4 variants emerge every 1-2 years causing major epidemics...
  22. ncbi Diagnosis of viral gastroenteritis by simultaneous detection of Adenovirus group F, Astrovirus, Rotavirus group A, Norovirus genogroups I and II, and Sapovirus in two internally controlled multiplex real-time PCR assays
    Noortje M van Maarseveen
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Virol 49:205-10. 2010
    Norovirus, Rotavirus group A, Astrovirus, Sapovirus and Adenovirus serotypes 40 and 41, are common causes of gastroenteritis. Conventional diagnosis of these causative agents is based on antigen detection and electron microscopy.
  23. pmc Comparative evolution of GII.3 and GII.4 norovirus over a 31-year period
    Denali Boon
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    J Virol 85:8656-66. 2011
    Noroviruses are the most common cause of epidemic gastroenteritis. Genotype II.3 is one of the most frequently detected noroviruses associated with sporadic infections...
  24. pmc Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns
    Pengwei Huang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol 79:6714-22. 2005
    Noroviruses, an important cause of acute gastroenteritis, have been found to recognize human histo-blood group antigens (HBGAs) as receptors. Four strain-specific binding patterns to HBGAs have been described in our previous report...
  25. ncbi Changes in causes of acute gastroenteritis in the United Kingdom over 15 years: microbiologic findings from 2 prospective, population-based studies of infectious intestinal disease
    Clarence C Tam
    Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Clin Infect Dis 54:1275-86. 2012
    ..We examined changes in etiology and diagnostic yield of IID cases over 15 years...
  26. ncbi Outbreaks of acute gastroenteritis transmitted by person-to-person contact--United States, 2009-2010
    Mary E Wikswo
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, CDC, 1600 Clifton Rd, NE, MS A 34, Atlanta, GA 30333, USA
    MMWR Surveill Summ 61:1-12. 2012
    Approximately 179 million cases of acute gastroenteritis (AGE) occur in the United States each year, and outbreaks of AGE are a substantial public health problem...
  27. pmc Chimpanzees as an animal model for human norovirus infection and vaccine development
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:325-30. 2011
    Noroviruses are global agents of acute gastroenteritis, but the development of control strategies has been hampered by the absence of a robust animal model...
  28. pmc Campylobacter jejuni--an emerging foodborne pathogen
    S F Altekruse
    U S Food and Drug Administration, Blacksburg, Virginia, USA
    Emerg Infect Dis 5:28-35. 1999
    ..Mishandling of raw poultry and consumption of undercooked poultry are the major risk factors for human campylobacteriosis. Efforts to prevent human illness are needed throughout each link in the food chain...
  29. ncbi Epidemiologic and molecular trends of "Norwalk-like viruses" associated with outbreaks of gastroenteritis in the United States
    Rebecca L Fankhauser
    Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 186:1-7. 2002
    Between July 1997 and June 2000, fecal specimens from 284 outbreaks of nonbacterial gastroenteritis were submitted to the Centers for Disease Control and Prevention for testing for "Norwalk-like viruses" (NLVs)...
  30. ncbi Laboratory efforts to cultivate noroviruses
    Erwin Duizer
    National Institutes for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    J Gen Virol 85:79-87. 2004
    Noroviruses (NoVs) are a leading cause of gastroenteritis worldwide and are recognized as the foremost cause of foodborne illness. Despite numerous efforts, routine cell cultures have failed to yield replicating NoV...
  31. pmc Coexistence of multiple genotypes, including newly identified genotypes, in outbreaks of gastroenteritis due to Norovirus in Japan
    Tsutomu Kageyama
    Department of Clinical Genomics, BML, Inc, Matoba 1361 1, Kawagoe, Saitama 350 1101, Japan
    J Clin Microbiol 42:2988-95. 2004
    Norovirus (NV) (formerly called Norwalk-like virus) is the most common cause of acute nonbacterial gastroenteritis in humans...
  32. ncbi Impact of an emergent norovirus variant in 2009 on norovirus outbreak activity in the United States
    Catherine Yen
    Epidemic Intelligence Service Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 53:568-71. 2011
    ..We collected norovirus outbreak data from 30 states to assess whether this new strain was associated with increased acute gastroenteritis activity. No increase in norovirus outbreaks was observed during the 2009-2010 winter.
  33. pmc A novel bocavirus associated with acute gastroenteritis in Australian children
    Jane L Arthur
    Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, Australia
    PLoS Pathog 5:e1000391. 2009
    Acute gastroenteritis (AGE) is a common illness affecting all age groups worldwide, causing an estimated three million deaths annually...
  34. pmc Acute gastroenteritis surveillance through the National Outbreak Reporting System, United States
    Aron J Hall
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 19:1305-9. 2013
    Implemented in 2009, the National Outbreak Reporting System provides surveillance for acute gastroenteritis outbreaks in the United States resulting from any transmission mode...
  35. ncbi Symptomatic and asymptomatic infections of rotavirus, norovirus, and adenovirus among hospitalized children in Xi'an, China
    Shuwan Zhang
    The First Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    J Med Virol 83:1476-84. 2011
    ..Rotavirus (RV), norovirus (NoV), and adenovirus (AdV) have been reported as the common viral pathogens of acute gastroenteritis in children...
  36. pmc Novel norovirus recombinants and of GII.4 sub-lineages associated with outbreaks between 2006 and 2010 in Belgium
    Elisabeth Mathijs
    Department of Infectious and Parasitic Diseases, Veterinary Virology and Animal Viral Diseases, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
    Virol J 8:310. 2011
    Noroviruses (NoVs) are an important cause of acute gastroenteritis in humans worldwide...
  37. pmc Incidence of acute gastroenteritis and role of norovirus, Georgia, USA, 2004-2005
    Aron J Hall
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:1381-8. 2011
    Approximately 179 million cases of acute gastroenteritis (AGE) occur annually in the United States. However, lack of routine clinical testing for viruses limits understanding of their role among persons seeking medical care...
  38. ncbi Nontyphoidal salmonellosis
    E L Hohmann
    Infectious Diseases Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 32:263-9. 2001
    Nontyphoidal Salmonella are important foodborne pathogens that cause gastroenteritis, bacteremia, and subsequent focal infection...
  39. ncbi Rotavirus vaccines in Belgium: policy and impact
    Tessa Braeckman
    Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium
    Pediatr Infect Dis J 30:S21-4. 2011
    ..Shortly after introduction, a nation-wide recommendation was issued and despite the fact that both rotavirus vaccines are offered through partial reimbursement, vaccine uptake has already reached a high level (at least 90%)...
  40. ncbi Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial
    George E Armah
    Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
    Lancet 376:606-14. 2010
    Rotavirus gastroenteritis causes many deaths in infants in sub-Saharan Africa...
  41. pmc Burden of rotavirus gastroenteritis in the Middle Eastern and North African pediatric population
    Hanane Khoury
    BioMedCom Consultants Inc, 1405 TransCanada Highway, Suite 310, Montreal, Quebec H9P 2V9, Canada
    BMC Infect Dis 11:9. 2011
    Rotavirus gastroenteritis (RVGE) is the most common cause of severe childhood diarrhea worldwide...
  42. pmc The complete genome of klassevirus - a novel picornavirus in pediatric stool
    Alexander L Greninger
    Howard Hughes Medical Institute, Departments of Medicine, Biochemistry, and Microbiology, University of California, San Francisco, California 94143, USA
    Virol J 6:82. 2009
    ..Modern technologies, especially deep sequencing, allow rapid, high-throughput screening of clinical samples such as stool for new infectious agents associated with human disease...
  43. ncbi Burden of rotavirus gastroenteritis and distribution of rotavirus strains in Asia: a systematic review
    Kosuke Kawai
    Temple University, School of Pharmacy, 3307N Broad Street, Philadelphia, PA 19140, USA
    Vaccine 30:1244-54. 2012
    Rotavirus is the leading cause of severe diarrhea in children worldwide. We systematically reviewed the burden of rotavirus gastroenteritis (RVGE) and distribution of rotavirus strains in Asia.
  44. pmc New adenovirus species found in a patient presenting with gastroenteritis
    Morris Saffold Jones
    Clinical Investigation Facility, David Grant USAF Medical Center, 101 Bodin Circle, Travis AFB, CA 94535, USA
    J Virol 81:5978-84. 2007
    ..Los Angeles County Public Health Department from each of five stool specimens submitted from an outbreak of gastroenteritis. Electron microscopy and an adenovirus-specific monoclonal antibody confirmed this agent to be an adenovirus...
  45. pmc Complete nucleotide sequence and genetic organization of Aichi virus, a distinct member of the Picornaviridae associated with acute gastroenteritis in humans
    T Yamashita
    Department of Virology, Aichi Prefectural Institute of Public Health, Nagoya, Aichi 462 8576, Japan
    J Virol 72:8408-12. 1998
    The complete nucleotide sequence of a novel enteric virus, Aichi virus, associated with nonbacterial acute gastroenteritis in humans was determined...
  46. pmc Phylodynamic reconstruction reveals norovirus GII.4 epidemic expansions and their molecular determinants
    J Joukje Siebenga
    National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands
    PLoS Pathog 6:e1000884. 2010
    Noroviruses are the most common cause of viral gastroenteritis. An increase in the number of globally reported norovirus outbreaks was seen the past decade, especially for outbreaks caused by successive genogroup II genotype 4 (GII...
  47. ncbi Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study
    Alexandre C Linhares
    Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministry of Health, Belem, Para, Brazil
    Lancet 371:1181-9. 2008
    Peak incidence of rotavirus gastroenteritis is seen in infants between 6 and 24 months of age...
  48. pmc Cellular and humoral immunity following Snow Mountain virus challenge
    Lisa Lindesmith
    School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 79:2900-9. 2005
    ..To our knowledge, this is the first report characterizing T-cell and cytokine responses following live norovirus challenge...
  49. pmc Incidence and risk factors for community-acquired acute gastroenteritis in north-west Germany in 2004
    C Karsten
    Children s Hospital Prof Hess, Klinikum Bremen Mitte, Sankt Jürgen Strasse, 28177 Bremen, Germany
    Eur J Clin Microbiol Infect Dis 28:935-43. 2009
    In developed countries, acute gastroenteritis (AGE) is a major source of morbidity. However, only a few studies have estimated its incidence and the associated medical burden...
  50. ncbi Burden of rotavirus disease in European Union countries
    Montse Soriano-Gabarro
    GlaxoSmithKline Biologicals, Rixensart, Belgium
    Pediatr Infect Dis J 25:S7-S11. 2006
    ..With the introduction of new rotavirus vaccines in sight, rotavirus gastroenteritis may be regarded as the single most frequent vaccine-preventable disease among children in the EU.
  51. ncbi Viral etiology and incidence associated with acute gastroenteritis in a 5-year survey in Gyeonggi province, South Korea
    Jeong Weon Huh
    Gyeonggido Institute of Health and Environment, Suwon, Gyeonggi do 440 290, South Korea
    J Clin Virol 44:152-6. 2009
    Acute gastroenteritis caused by viruses is one of the leading causes of childhood morbidity.
  52. ncbi Genetic analysis of norovirus in children affected with acute gastroenteritis in Beijing, 2004-2007
    Li Guo
    National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China
    J Clin Virol 44:94-8. 2009
    Noroviruses (NoVs) are a major cause of acute gastroenteritis in children, but prevalence and circulation of NoVs in China have not been well characterized.
  53. pmc Are human P[14] rotavirus strains the result of interspecies transmissions from sheep or other ungulates that belong to the mammalian order Artiodactyla?
    Jelle Matthijnssens
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Virol 83:2917-29. 2009
    A limited number of human G6P[14] rotavirus strains that cause gastroenteritis in humans have been isolated in Europe and Australia...
  54. ncbi Reduction in acute gastroenteritis hospitalizations among US children after introduction of rotavirus vaccine: analysis of hospital discharge data from 18 US states
    Aaron T Curns
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    J Infect Dis 201:1617-24. 2010
    ..We compared hospitalization rates for acute gastroenteritis among US children aged <5 years during pre-RV5 rotavirus seasons from 2000 through 2006 with those during ..
  55. ncbi Adenoviruses associated with acute gastroenteritis in hospitalized and community children up to 5 years old in Rio de Janeiro and Salvador, Brazil
    Edson Pereira Filho
    Subdivisão de Pesquisa, Instituto de Biologia do Exército, Rua Francisco Manuel 102, Benfica, Rio de Janeiro, RJ, CEP 20911 270, Brazil
    J Med Microbiol 56:313-9. 2007
    Acute gastroenteritis is a major source of morbidity and mortality among young children in developed and developing countries. Human adenoviruses (HAdVs), and in particular species F, are related to childhood diarrhoea worldwide...
  56. ncbi Molecular epidemiology of noroviruses in children and adults with acute gastroenteritis in Wuhan, China, 2007-2010
    Yuan Hong Wang
    Virology Section, Wuhan Centers for Disease Prevention and Control, Wuhan 430015, Hubei, People s Republic of China
    Arch Virol 157:2417-24. 2012
    To study epidemiological features and genetic characteristics of noroviruses in children and adults with acute gastroenteritis, fecal specimens were collected in three hospitals from Jan. 2007 to May 2010 in Wuhan, China...
  57. ncbi Molecular epidemiology of noroviruses associated with acute sporadic gastroenteritis in children: global distribution of genogroups, genotypes and GII.4 variants
    T N Hoa Tran
    Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, The Global Center of Excellence, Nagasaki University, Nagasaki, Japan
    J Clin Virol 56:185-93. 2013
    Noroviruses are a leading cause of epidemic and sporadic acute gastroenteritis worldwide...
  58. ncbi Recombinant norovirus GII.g/GII.12 gastroenteritis in children
    Giovanni M Giammanco
    Dipartimento di Scienze per la Promozione della Salute, G D Alessandro, Sezione di Microbiologia, Universita di Palermo, via del Vespro 133, 90127 Palermo, Italy
    Infect Genet Evol 12:169-74. 2012
    ..g/GII.12 norovirus (NoV) strains emerged in 2008 in Australia and subsequently have been associated with gastroenteritis outbreaks worldwide. In the winter season 2009-2010 GII...
  59. ncbi Viral load and genotypes of noroviruses in symptomatic and asymptomatic children in Southeastern Brazil
    Débora Maria Pires Gonçalves Barreira
    Nucleo de Doencas Infecciosas, Health Science Center, Federal University of Espirito Santo, Av Marechal Campos 1468, 29043 900 Maruipe, Vitoria, ES, Brazil
    J Clin Virol 47:60-4. 2010
    Noroviruses (NoVs) are a major etiological agent of sporadic acute gastroenteritis worldwide.
  60. pmc Vaccine-derived NSP2 segment in rotaviruses from vaccinated children with gastroenteritis in Nicaragua
    Filemon Bucardo
    Department of Microbiology, University of Leon, UNAN Leon, Nicaragua
    Infect Genet Evol 12:1282-94. 2012
    ..failure in this country, we sequenced the genomes of RVs recovered from vaccinated Nicaraguan children with gastroenteritis. The results revealed that all had genotype specificities typical for human RVs (11 G1P[8], 1 G3P[8]) and ..
  61. ncbi Direct and indirect effects of rotavirus vaccination upon childhood hospitalizations in 3 US Counties, 2006-2009
    Daniel C Payne
    Epidemiology Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 53:245-53. 2011
    Routine rotavirus vaccination of US infants began in 2006. We conducted active, population-based surveillance for rotavirus gastroenteritis hospitalizations in 3 US counties to assess vaccine impact.
  62. ncbi Reduction in gastroenteritis in United States children and correlation with early rotavirus vaccine uptake from national medical claims databases
    Margaret M Cortese
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 29:489-94. 2010
    ..We sought to estimate rotavirus disease reduction among children in hospital and office settings in the 4 US regions following rotavirus vaccine introduction and to estimate vaccine uptake...
  63. ncbi Noroviruses as a major cause of acute gastroenteritis in children in Finland, 2009-2010
    Leena Puustinen
    Vaccine Research Center, University of Tampere Medical School, Tampere, Finland
    Scand J Infect Dis 43:804-8. 2011
    Noroviruses are, after rotaviruses, the second most common cause of acute gastroenteritis in young children...
  64. ncbi Universal mass vaccination against rotavirus gastroenteritis: impact on hospitalization rates in austrian children
    Maria Paulke-Korinek
    Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology, Pathophysiology and Immunology, Medical University Vienna, Vienna, Austria
    Pediatr Infect Dis J 29:319-23. 2010
    ..Since July 2007, rotavirus vaccinations have been subsidized in Austria for all children from the seventh week up to the sixth month of life. Vaccination coverage over the whole period was 72% with an increase to 87% in 2008...
  65. pmc Impact of community-acquired paediatric rotavirus gastroenteritis on family life: data from the REVEAL study
    Marie Van der Wielen
    The Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Belgium
    BMC Fam Pract 11:22. 2010
    Rotavirus is the leading cause of acute gastroenteritis (AGE) and the most frequent cause of severe diarrhoea in children aged less than 5 years...
  66. ncbi Diarrhoea in children: an interface between developing and developed countries
    Nikhil Thapar
    Centre for Adult and Paediatric Gastroenterology, Institute of Cell and Molecular Science, Barts and The London, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Lancet 363:641-53. 2004
    ..Oral rehydration therapies are the mainstay of management of gastroenteritis, and their composition continues to improve...
  67. ncbi Susceptibility to winter vomiting disease: a sweet matter
    Gustaf E Rydell
    Dept of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Rev Med Virol 21:370-82. 2011
    ..cause of winter vomiting disease, has emerged in recent years to be a major cause of sporadic and epidemic gastroenteritis worldwide. The virus has been estimated to cause >200,000 deaths each year in developing countries...
  68. pmc Serological correlate of protection against norovirus-induced gastroenteritis
    Amanda Reeck
    Departments of Molecular Virology, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 202:1212-8. 2010
    Norovirus infection is the leading cause of acute nonbacterial gastroenteritis. Histoblood group antigens (HBGAs) are host susceptibility determinants for Norwalk virus (NV) infection...
  69. ncbi Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries
    Javier Diez-Domingo
    Area de Investigación en Vacunas, Centro Superior de Investigación en Salud Pública, CSISP, Centre for Public Health Research, Avda Catalunya 21, 46020 Valencia, Spain
    Eur J Pediatr 170:213-22. 2011
    This observational, prospective study was undertaken to estimate the burden of rotavirus (RV) gastroenteritis (GE) leading to general practitioner (GP)/family paediatrician (FP) visits among children aged <5 years in Czech Republic, ..
  70. ncbi Decline and change in seasonality of US rotavirus activity after the introduction of rotavirus vaccine
    Jacqueline E Tate
    Division of Viral Diseases, Centers for Disease Control andPrevention, Atlanta, Georgia 30333, USA
    Pediatrics 124:465-71. 2009
    ..In 2006, routine immunization of US infants against rotavirus was initiated. We assessed national, regional, and local trends in rotavirus testing and detection before and after vaccine introduction...
  71. pmc Identification of a novel astrovirus (astrovirus VA1) associated with an outbreak of acute gastroenteritis
    Stacy R Finkbeiner
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 83:10836-9. 2009
    ..study, random Sanger sequencing and pyrosequencing approaches were used to analyze fecal specimens from a gastroenteritis outbreak of unknown etiology in a child care center...
  72. pmc A novel picornavirus associated with gastroenteritis
    Linlin Li
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Virol 83:12002-6. 2009
    ..A statistical association was seen between virus shedding and unexplained cases of gastroenteritis in Nepal (P = 0.0056)...
  73. ncbi Detection of genogroup IV noroviruses in environmental and clinical samples and partial sequencing through rapid amplification of cDNA ends
    G La Rosa
    Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Arch Virol 153:2077-83. 2008
    Noroviruses (NoVs) give rise to clinically relevant gastroenteritis in all age groups and are widely distributed in both clinical and environmental settings...
  74. pmc Prevalence of rotavirus, adenovirus, norovirus, and astrovirus infections and coinfections among hospitalized children in northern France
    Adissa Tran
    Laboratoire de Virologie, Centre Hospitalier Universitaire de Reims, Service de Microbiologie, Hopital Robert Debre, avenue du Général Koenig, 51092 Reims Cedex, France
    J Clin Microbiol 48:1943-6. 2010
    From January to December 2007, 973 stool specimens were prospectively collected from children hospitalized for gastroenteritis signs or from neonates and premature cases who were born in two French hospital settings in the north of ..
  75. pmc Rapid evolution of pandemic noroviruses of the GII.4 lineage
    Rowena A Bull
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia
    PLoS Pathog 6:e1000831. 2010
    Over the last fifteen years there have been five pandemics of norovirus (NoV) associated gastroenteritis, and the period of stasis between each pandemic has been progressively shortening...
  76. ncbi Viral shape-shifting: norovirus evasion of the human immune system
    Eric F Donaldson
    University of North Carolina, Department of Epidemiology, Chapel Hill, North Carolina 27599, USA
    Nat Rev Microbiol 8:231-41. 2010
    Noroviruses are the most common cause of food-borne gastroenteritis worldwide, and explosive outbreaks frequently occur in community settings, where the virus can immobilize large numbers of infected individuals for 24-48 hours, making ..
  77. ncbi Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial
    K Zaman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Lancet 376:615-23. 2010
    Rotavirus vaccine has proved effective for prevention of severe rotavirus gastroenteritis in infants in developed countries, but no efficacy studies have been done in developing countries in Asia...
  78. ncbi Identification of a distinct common strain of "Norwalk-like viruses" having a global distribution
    J S Noel
    Viral Gastroenteritis Section, Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 179:1334-44. 1999
    Norwalk-like viruses" (NLVs) are the most common cause of outbreaks of nonbacterial gastroenteritis. During molecular surveillance of NLV strains from 152 outbreaks of gastroenteritis that occurred in the US between August 1993 and July ..
  79. ncbi Norwalk virus: how infectious is it?
    Peter F M Teunis
    RIVM, Bilthoven, The Netherlands
    J Med Virol 80:1468-76. 2008
    Noroviruses are major agents of viral gastroenteritis worldwide. The infectivity of Norwalk virus, the prototype norovirus, has been studied in susceptible human volunteers...
  80. pmc Global seasonality of rotavirus infections
    S M Cook
    Viral Gastroenteritis Unit, Centers for Disease Control, Atlanta, GA 30333
    Bull World Health Organ 68:171-7. 1990
    ..the etiology of childhood diarrhoea were compiled in order to investigate the seasonal patterns of rotavirus gastroenteritis and consider their implications for transmission of the virus...
  81. pmc Detection and molecular characterization of a canine norovirus
    Vito Martella
    University of Bari, Bari, Italy
    Emerg Infect Dis 14:1306-8. 2008
    ..We identified a novel calicivirus in a pup with enteritis. The isolate was related genetically (90.1% aa identity in the capsid protein) to a lion norovirus strain...
  82. ncbi Design and evaluation of a primer pair that detects both Norwalk- and Sapporo-like caliciviruses by RT-PCR
    X Jiang
    Center for Pediatric Research, Children s Hospital of the King s Daughters, Eastern Virginia Medical School, Norfolk 23510 1001, USA
    J Virol Methods 83:145-54. 1999
    ..This primer pair is useful for broad detection of HuCVs for clinical and epidemiologic studies as well as for environmental monitoring...
  83. ncbi Rotavirus incidence and genotype distribution before and after national rotavirus vaccine introduction in Belgium
    Mark Zeller
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Vaccine 28:7507-13. 2010
    ..The incidence of rotavirus gastroenteritis has been monitored in the Gasthuisberg University Hospital (GUH), Belgium since 1986, and since 1999 the ..
  84. ncbi Outbreak of Vibrio parahaemolyticus gastroenteritis associated with Alaskan oysters
    Joseph B McLaughlin
    Division of Public Health, Alaska Department of Health and Social Services, Anchorage, AK 99503, USA
    N Engl J Med 353:1463-70. 2005
    Vibrio parahaemolyticus, the leading cause of seafood-associated gastroenteritis in the United States, typically is associated with the consumption of raw oysters gathered from warm-water estuaries. We describe a recognized outbreak of V...
  85. pmc Short- and long-term effects of bacterial gastrointestinal infections
    Anders Ternhag
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Emerg Infect Dis 14:143-8. 2008
    ..2, 95% CI 12.0-26.5), and Campylobacter infection (SIR 6.3, 95% CI 3.5-10.4). Acute gastroenteritis is sometimes associated with disease manifestations from several organ systems that may require ..
  86. pmc Genetic diversity among food-borne and waterborne norovirus strains causing outbreaks in Sweden
    Maria Lysén
    Department of Virology, Swedish Institute for Infectious Disease Control, Solna, Sweden
    J Clin Microbiol 47:2411-8. 2009
    ..The high degree of genetic diversity found among norovirus strains causing food-borne and waterborne infections stresses the importance of the use of broad reaction detection methods when such outbreaks are investigated...
  87. pmc Novel norovirus in dogs with diarrhea
    Joao Rodrigo Mesquita
    University of Porto, Porto, Portugal
    Emerg Infect Dis 16:980-2. 2010
    ..We found canine norovirus in 40% and 9% of dogs with and without diarrhea, respectively. The virus was genetically unrelated to other noroviruses and constitutes a tentative new genogroup...
  88. pmc Norovirus GII.4 strain antigenic variation
    Lisa C Lindesmith
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 85:231-42. 2011
    Noroviruses are the principal cause of epidemic gastroenteritis worldwide. Multiple reports have concluded that the major capsid proteins of GII...
  89. ncbi Age distribution of paediatric rotavirus gastroenteritis cases in Europe: the REVEAL study
    Carlo Giaquinto
    Department of Paediatrics, University of Padua, Via Giustiniani 3, Padua, Italy
    Scand J Infect Dis 42:142-7. 2010
    ..France, Germany, Italy, Spain, Sweden, and the UK, to estimate the incidence of community-acquired acute gastroenteritis (AGE) and rotavirus gastroenteritis (RVGE) in children under 5 y of age seeking medical care in 3 settings: ..
  90. ncbi Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: a multicentre case-control study
    Patrick C Y Woo
    Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital, Pokfulam, Hong Kong, People s Republic of China
    Lancet 363:1941-7. 2004
    Laribacter hongkongensis has been recovered from several patients with gastroenteritis. However, the causative role of this organism in human gastroenteritis is still unproven, and sources of the bacterium are unknown...
  91. pmc Genetic heterogeneity and recombination in canine noroviruses
    Vito Martella
    Department of Veterinary Public Health, University of Bari, Valenzano, Bari, Italy
    J Virol 83:11391-6. 2009
    ..9% nucleotide identity and 98.9% amino acid identity) identified from oysters in Japan, indicating that similar viruses may be common environmental contaminants...
  92. ncbi Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study
    Wei Xia Cheng
    National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China
    Clin Infect Dis 47:161-7. 2008
    Human bocavirus (HBoV) was recently discovered in children with respiratory tract disease and gastroenteritis. The causative role of HBoV in human gastroenteritis remains uncertain, and, to our knowledge, no previous case-control study ..
  93. ncbi The benefits of using clinical pathways for managing acute paediatric illness in an emergency department
    G J Browne
    Department of Emergency Medicine, The Children s Hospital at Westmead, Royal Alexandra Hospital for Children, NSW, Australia
    J Qual Clin Pract 21:50-5. 2001
    ..This was a before and after study conducted on the effectiveness of three clinical pathways (gastroenteritis, asthma, and croup) in the emergency department of the Children's Hospital at Westmead, conducted over two ..
  94. ncbi Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease
    Luis Alberto García Rodríguez
    Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain
    Gastroenterology 130:1588-94. 2006
    ..We explored the relationship between infectious gastroenteritis and the occurrence of IBD using data from the General Practice Research Database.
  95. pmc Acute bacterial gastroenteritis: a study of adult patients with positive stool cultures treated in the emergency department
    S S W Chan
    Department of Accident and Emergency, Prince of Wales Hospital, The Chinese University of Hong Kong
    Emerg Med J 20:335-8. 2003
    To investigate the presenting clinical features of acute bacterial gastroenteritis in adult patients treated as outpatients in the emergency department (ED), and the pathogens responsible in this setting and population; and to identify ..
  96. ncbi Burden of acute gastrointestinal illness in the Metropolitan region, Chile, 2008
    M K Thomas
    Department of Population Medicine, University of Guelph, Guelph, Canada
    Epidemiol Infect 139:560-71. 2011
    ..This study expands on the discussion of recall bias in retrospective population studies and reports the first population-based burden and distribution of GI estimates in Chile...
  97. ncbi Epidemiology and economic burden of rotavirus gastroenteritis in hospitals and paediatric clinics in Taiwan, 2005-2006
    T Christopher Mast
    Merck and Co, Inc, PO Box 1000, North Wales, PA 19486, USA
    Vaccine 28:3008-13. 2010
    ..Prospective, cross-sectional surveillance for acute gastroenteritis (AGE) was conducted in hospitals and outpatient paediatric clinics in Taiwan to assess the prevalence of ..
  98. ncbi Burden of acute gastroenteritis and healthcare-seeking behaviour in France: a population-based study
    D van Cauteren
    Department of Infectious Diseases, Institut de veille sanitaire French Institute for Public Health Surveillance, Saint Maurice, France
    Epidemiol Infect 140:697-705. 2012
    In France surveillance underestimates the true burden of acute gastroenteritis (AG)...
  99. pmc Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability
    Grant S Hansman
    Structural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, 40 Convent Drive, Building 40, Room 4508, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 85:6687-701. 2011
    Noroviruses are the dominant cause of outbreaks of gastroenteritis worldwide, and interactions with human histo-blood group antigens (HBGAs) are thought to play a critical role in their entry mechanism...
  100. pmc Norovirus outbreaks from drinking water
    Leena Maunula
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, HUCH Laboratory Diagnostics, University of Helsinki, 00014 Helsinki, Finland
    Emerg Infect Dis 11:1716-21. 2005
    ..In all but 1 instance, the amplicon sequence was identical to that recovered from the patients. The ubiquity of waterborne norovirus outbreaks calls for measures to monitor water for viruses...
  101. ncbi Burden of rotavirus and other enteropathogens among children with diarrhea in Burkina Faso
    Leon W Nitiema
    Centre de Recherche Biomoléculaire Pietro Annigoni Saint Camille CERBA LABIOGENE, Universite de Ouagadougou, 01 BP 364 Ouagadougou 01, Burkina Faso
    Int J Infect Dis 15:e646-52. 2011
    ..The aim of this study was to investigate the prevalence and epidemiology of enteric pathogens causing gastroenteritis in young children, with a focus on rotavirus, and to investigate the levels of malnutrition and other ..

Research Grants76

  1. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    ..Rotaviruses are the major cause of acute viral gastroenteritis in children under 5 years of age...
  2. Intracellular Serpin Regulation of Intestinal Cell Necrosis
    GARY ARTHUR SILVERMAN; Fiscal Year: 2012
    ..common pathologic feature of many gastrointestinal disorders including inflammatory bowel disease, infectious gastroenteritis and necrotizing enterocolitis...
  3. OmpR and SsrB Regulation of Salmonella Virulence
    Linda J Kenney; Fiscal Year: 2013
    ..Salmonella-associated acute gastroenteritis is a significant cause of morbidity among travelers, deployed military personnel and high population density ..
  4. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    ..This same histological event of massive transepithelial migration of PMNs occurs in the acute phase of gastroenteritis induced by Salmonella enterica serovar Typhimurium (salmonellosis)...
  5. Breakthroughs to advance the in vitro propagation of human noroviruses
    Qiuhong Wang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human noroviruses (HuNoVs) are the leading cause of gastroenteritis worldwide causing 23 million cases of gastroenteritis annually and substantial economic impacts in the US alone...
  6. Molecular Mechanism of cell-cell spread of Listeria in polarized epithelial cells
    KEITH PATRICK IRETON; Fiscal Year: 2013
    ..provided by applicant): Listeria monocytogenes is a food-borne, intracellular pathogen that causes gastroenteritis, abortions, or meningitis with a high mortality rate...
  7. Causes of rotavirus vaccine failure in Zambian children
    Roma Chilengi; Fiscal Year: 2013
    ..provided by applicant): Despite being vaccine preventable, rotavirus is the most important cause of severe gastroenteritis among children and kills half a million children each year worldwide...
  8. Gut microflora: Impact on neonatal immunity, viral gastroenteritis and vaccines
    ANASTASIA NICKOLAEVNA VLASOVA; Fiscal Year: 2013
    ..Our findings will contribute to alternative low cost probiotic treatments applicable to infants (or mothers) to moderate HRV disease, enhance oral vaccine efficacy, and reduce infant morbidity and mortality. ..
  9. Coordination of metabolism and virulence during infection
    Tony Romeo; Fiscal Year: 2013
    ..2600 serovars of Salmonella that exhibit a variety of host ranges and disease manifestations, which include gastroenteritis, bacteremia, metastatic infections and paratyphoid and typhoid fevers...
  10. Effect of a sanitation &nutrition intervention on HIV-exposed infant health
    JEAN HAWES HUMPHREY; Fiscal Year: 2012
    ..one way to minimize MTCT, but several studies in developing countries have observed high rates of associated gastroenteritis, growth faltering, and mortality...
  11. Novel vaccine against Norovirus
    Xi Jiang; Fiscal Year: 2013
    ..Narrative/Relevance: Noroviruses (NVs) are an important cause of acute gastroenteritis, affecting people of all ages, in both developed and developing countries...
  12. Viral Gastroenteritis: Basis of Protection and Virulence
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    ..They also represent a highly tractable system to study basic aspects of innate, acquired and mucosal immunity and viral pathogenesis, all important issues for the future of infectious disease prevention and treatment. ..
  13. EPIDEMIOLOGY OF HELICOBACTER PYLORI TRANSMISSION
    Julie Parsonnet; Fiscal Year: 2010
    ..In our prior submission, we identified protective effects of H. pylori on gastroenteritis incidence...
  14. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..S. flexneri along with numerous other important pathogens such as Yersinia pestis (plague), Salmonella (gastroenteritis), and Pseudomonas aeruginosa (lung infection) utilize the type III secretion system (TTSS) as a means of ..
  15. Campylobacter jejuni outer membrane protein vaccine
    Stuart Thompson; Fiscal Year: 2009
    Campylobacter jejuni is the leading cause of bacterial gastroenteritis in the U.S., and has been classified by the NIH as a Category B Bioterrorism Agent due to its ability to cause food-borne and water-borne outbreaks...
  16. Mechanisms of Immune Modulation by Probiotics
    Lijuan Yuan; Fiscal Year: 2012
    ..Rotavirus gastroenteritis poses a tremendous ongoing disease burden in the US and worldwide, with costs to health care and society ..
  17. Susceptibility and Protective Immunity to Noroviruses
    Ralph S Baric; Fiscal Year: 2013
    Noroviruses are the most important cause of food-borne gastroenteritis worldwide and cause ~85-96% of selected outbreaks of acute non-bacterial gastroenteritis in the US...
  18. Ribozymes for studies and treatment of cytomegalovirus infections
    Fenyong Liu; Fiscal Year: 2012
    ..Disseminated HCMV infection in these patients is usually associated with gastroenteritis, pneumonia, and sight-threatening retinitis...
  19. Microbial Invasion of the Intestine at the Cell Extrusion Zone of the Villus Tip
    Manuel R Amieva; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Invasive gastroenteritis and enteric fever are major sources of mortality and morbidity worldwide...
  20. An Integrated Diagnostic System for Rapid Antimicrobial Susceptibility Testing
    VINCENT JEN JR GAU; Fiscal Year: 2013
    ..Pathogens responsible for many of the common human infectious diseases such as urinary tract infection (UTI), gastroenteritis, pneumonia, and wound infections have proven to be highly adept in acquiring mechanisms of antimicrobial ..
  21. Newcastle Disease Virus Vectored Vaccines for Norovirus Infection
    Siba K Samal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human norovirus infection is the most common cause of viral gastroenteritis worldwide...
  22. Enteric Virus Calcium Channel Inhibitors
    Joseph M Hyser; Fiscal Year: 2013
    ..Rotaviruses (RV) are the leading cause of childhood viral gastroenteritis, resulting in diarrhea, vomiting and life-threatening dehydratio...
  23. The role of Atg16L1 in Graft-Versus-Host-Disease
    VANESSA MARIE HUBBARD-LUCEY; Fiscal Year: 2013
    ..Norovirus infection, the most common cause of gastroenteritis worldwide, has been shown to be a complication for GVHD...
  24. Interactions of Enteropathogenic E Coli with Intestinal Epithelial Cells
    Gail A Hecht; Fiscal Year: 2013
    ..In addition, active duty military personnel who experienced infectious gastroenteritis had an increased risk (odds ratio, 1.4) for the development of inflammatory bowel disease (2)...
  25. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William E Whitehead; Fiscal Year: 2012
    ..to IBS-Pn, and we hypothesize that inflammatory genes may require the environmental trigger of bacterial gastroenteritis for expression while genes related to pain sensitivity may be modulated by childhood social learning through ..
  26. Innate and adaptive immune responses at the respiratory mucosa
    Yasmin Thanavala; Fiscal Year: 2010
    ..particularly important as they impact on many diseases such as pneumonia, sinusitis, otitis media, COPD and gastroenteritis. Identifying the molecules/pathways involved in increased susceptibility or protection against subsequent ..
  27. Analysis of Coronavirus-Host Cell Interactions
    Shinji Makino; Fiscal Year: 2013
    ..SARS-CoV (SCoV), bat CoVs, and mouse hepatitis virus (MHV), and of alphaCoVs, which includes transmissible gastroenteritis virus (TGEV) and human CoV 229E, inhibits host gene expression...
  28. Role of the Listeria protein InlC and its host ligand Tuba in cell-cell spread
    KEITH PATRICK IRETON; Fiscal Year: 2009
    ..provided by applicant): Listeria monocytogenes is a food-borne, intracellular pathogen capable of causing gastroenteritis, meningitis, and abortions...
  29. Bacteria Based Agents for Therapy of AIDS Associated Infections
    Sangwei Lu; Fiscal Year: 2010
    ..Disseminated HCMV infection in these patients is usually associated with gastroenteritis, pneumonia, and sight-threatening retinitis...
  30. Virulence in Enteroaggregative Escherichia coli
    James P Nataro; Fiscal Year: 2013
    ..coli (EAEC) is an important diarrheal pathogen worldwide, and is the most common cause of bacterial gastroenteritis in the U.S...
  31. IMMUNITY AND PATHOGENESIS OF A NOVEL NOROVIRUS
    Herbert W Virgin; Fiscal Year: 2012
    ..Noroviruses (NoV, Category B Biodefense agents) are the major etiologic agent of nonbacterial, epidemic gastroenteritis worldwide, causing significant suffering, morbidity, and economic loss...
  32. PHOP REGULON AND SALMONELLA VIRULENCE
    Samuel I Miller; Fiscal Year: 2013
    ..These organisms are responsible for several disease syndromes, including enteric (typhoid) fever, gastroenteritis, bacteremias and focal infections...
  33. Recombinant Attenuated Bacterial Vaccines Against Biodefense Agents
    Roy Curtiss; Fiscal Year: 2013
    ..recombinant attenuated Salmonella Typhimurium, Paratyphi A and Typhi vaccines to prevent Salmonella-induced gastroenteritis, enteric fever and typhoid fever, respectively, and using these same attenuated vectors to deliver additional ..
  34. Campylbacter jejuni flagellar regulation and synthesis
    David R Hendrixson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Campylobacter jejuni is a leading cause of gastroenteritis in humans in the United States and in other countries throughout the world. According to the Centers for Disease Control, C...
  35. Bacteria Based Agents for Therapy of AIDS Associated Infections
    Sangwei Lu; Fiscal Year: 2013
    ..Disseminated HCMV infection in these patients is usually associated with gastroenteritis, pneumonia, and sight-threatening retinitis...
  36. Enhanced Surveillance for New Vaccine Preventable Diseases
    Mary A Staat; Fiscal Year: 2010
    ..of population-based sites to conduct active surveillance for acute respiratory infections (ARI) and acute gastroenteritis (AGE) in addition to providing a framework in which to study other important vaccine related questions...
  37. ENVIRONMENTAL TOBACCO SMOKE EXPOSURE AMONG CHILDREN HOSPITALIZED WITH PNEUMONIA
    Derek Williams; Fiscal Year: 2010
    ..To compare ETS exposure among children hospitalized with pneumonia with matched controls hospitalized with gastroenteritis 3...
  38. INNATE/ADAPTIVE IMMUNE RESPONSE TO SALMONELLA TYPHIMURIUM
    MUYIWA EMMANUEL AWONIYI; Fiscal Year: 2010
    ..Stym can cause gastroenteritis in people of all ages and severe invasive diseases in infants and immunocompromised individuals...
  39. Inflammasome Response to Bacterial Infection
    Edward A Miao; Fiscal Year: 2013
    ..are a significant public health threat in both developing and developed countries, causing Typhoid fever or gastroenteritis, and recently have been observed as emerging pathogens causing community acquired bacteremia in sub-Saharan ..
  40. Assessing feeding practices, immune activation, and HIV risk in African infants
    HEATHER BERYL JASPAN; Fiscal Year: 2013
    ..is unaffordable and is associated with high morbidity and mortality due to infectious diseases such as gastroenteritis and malnourishment...
  41. Targeting host deubiquitinases for broad spectrum anti-infective therapy
    Christiane Wobus; Fiscal Year: 2013
    ..Noroviruses cause an estimated 23 million infections and over half of all food-borne gastroenteritis outbreaks in the US every year yet no antivirals or vaccines exist to treat or prevent infections...
  42. Host Genetic Susceptibility and Immune Responses to Norovirus Infections
    HOONMO LEE KOO; Fiscal Year: 2012
    ..by applicant): Noroviruses (NoVs) are the most common cause of foodborne illnesses and acute non-bacterial gastroenteritis worldwide...
  43. Host Interactions of Salmonella typhimurium
    Charles L Bevins; Fiscal Year: 2013
    Salmonella-induced gastroenteritis is the single most common cause of death from food-borne illnesses associated with viruses, parasites or bacteria in the US. Our long-range goal is to elucidate the molecular mechanisms of S...
  44. Novel diagnostics and therapeutics for caliciviruses
    MARY KOLB ESTES; Fiscal Year: 2013
    ..all outbreaks (>95%) of nonbacterial foodborne and waterborne disease that result in 23 million cases of gastroenteritis annually in the US...
  45. Mucosal dendritic cell function following enteric virus infection
    Christopher F Cuff; Fiscal Year: 2010
    ..Besides gastroenteritis, other diseases caused by enteric viruses include hepatitis, myocarditis, and inflammation of the central ..
  46. Enhanced Surveillance for New Vaccine Preventable Diseases
    Rangaraj Selvarangan; Fiscal Year: 2013
    ..Our active surveillance system will monitor community rates of acute gastroenteritis (AGE) and acute respiratory illness (ARI) by prospectively enrolling children year-round in both our ..
  47. Salmonella SopA is a functional mimicry of eukaryotic E3 protein ubiquitin ligase
    Daoguo Zhou; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Salmonella enterica serovar Typhimurium causes mild gastroenteritis and more severe systematic infections in both humans and domestic animals...
  48. The Psp response of Yersinia enterocolitica
    Andrew J Darwin; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The bacterium Yersinia enterocolitica causes human gastroenteritis, and is closely related to the causative agent of Plague, Y. pestis...
  49. Structure and function of prokaryotic appendages by cryo-electron tomography
    Elizabeth R Wright; Fiscal Year: 2013
    ..are using several bacterial species, Vibrio cholerae and Vibrio vulnificus, human pathogens that cause severe gastroenteritis, diarrhea, and death;and Caulobacter crescentus, a well-established non-pathogenic model system...
  50. MOLECULAR AND FUNCTIONAL ANALYSES OF THE PMRA/PMRB REGULATORY SYSTEM
    EDUARDO GROISMAN; Fiscal Year: 2013
    ..In Salmonella enterica, which is the etiologic agent of typhoid fever and gastroenteritis, many of these LPS modifications are observed only under conditions that activate the PmrA/PmrB regulatory ..
  51. Regulation of T cell differentiation during enteric viral infection
    Vesselin Tomov; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Norovirus (NV) gastroenteritis is a major contributor to global morbidity and mortality, yet little is known about NV immunity and no effective vaccine exists...
  52. Evaluation of Protein Channel-Attenuated Salmonella Vaccines
    Xinghong Yang; Fiscal Year: 2010
    ..Salmonella enterica is a disease that causes a variety of food and water-borne illnesses, such as gastroenteritis and typhoid fever. It can infect a wide range of animal hosts and also humans...
  53. Antimicrobial peptide resistance in Campylobacter jejuni
    Jun Lin; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Campylobacter jejuni is the most prevalent foodborne bacterial pathogen causing human gastroenteritis in the U.S...
  54. Analysis of an orchestrated cell death mediated by Vibrio parahaemolytics T3SS1
    Kim Orth; Fiscal Year: 2013
    ..system 1 (T3SS1) of the gram-negative bacterium Vibrio parahaemolyticus;a major agent responsible for gastroenteritis outbreaks associated with the consumption of contaminated seafood. The prevalence of V...
  55. Structural Components of the Campylobacter jejuni Polar Flagellar Motor
    David R Hendrixson; Fiscal Year: 2013
    ..three disk structures associated with the polar flagellar motor of Campylobacter jejuni, a leading cause of gastroenteritis in humans in the United States and in other countries throughout the world, which are essential for promoting ..
  56. The Role of Human Milk in Infant Nutrition and Health
    Ardythe L Morrow; Fiscal Year: 2013
    ..diseases, three projects are proposed pertaining to the human milk glycans: 1) Inhibition of bacterial gastroenteritis;2) Inhibition of viral gastroenteritis;and 3) Modulation of inflammation, colonization, and mucosal ..
  57. Rapid and sensitive detection of Salmonella from blood, food and feces
    SHARON MEI TENNANT; Fiscal Year: 2013
    ..Non-typhoidal Salmonella (NTS) have long been known to be a cause of gastroenteritis and it is becoming increasingly recognized, both in the USA and globally, that multiple antibiotic-resistant ..
  58. Pathogenesis of Salmonella bacteremia
    Renee M Tsolis; Fiscal Year: 2013
    ..by applicant): In immunocompetent individuals, non-typhoidal Salmonella serotypes (NTS) are associated with gastroenteritis, a localized infection with low mortality manifesting as diarrhea, vomiting and intestinal cramping...
  59. Microbiota Outgrowth by Salmonella
    ANDREAS J BAUMLER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Salmonella enterica serotype Typhimurium (S. typhimurium) causes gastroenteritis, a diarrheal illness characterized by acute intestinal inflammation...
  60. Flagellin-induced gut epithelial chemokine secretion
    Andrew T Gewirtz; Fiscal Year: 2012
    ..Human disease caused by Salmonella can be divided into 2 primary categories: 1) gut-restricted self-limiting gastroenteritis and Typhoid fever...
  61. Phylogenomic epidemiology of Clostridium difficile
    Seth T Walk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gastroenteritis caused by the bacterium, Clostridium difficile, is a global healthcare problem and a common complication of antibiotic therapy. A subset of toxin-producing C...
  62. Structural Basis of Actin Cytoskeleton Dynamics
    Roberto Dominguez; Fiscal Year: 2013
    ..2. To understand the nucleation mechanism of VopL, a powerful nucleator and virulence factor produced by the gastroenteritis causing pathogen Vibrio parahaemolyticus...
  63. Investigations of the role of house flies as vectors for bacterial pathogens
    Dana Nayduch; Fiscal Year: 2009
    ..In rural areas of developing countries, hyperendemicity of gastroenteritis among infants and children is attributed to filth fly presence in combination with poor sanitation...
  64. Porcine Respiratory Coronavirus as a SARS Model
    Linda Saif; Fiscal Year: 2007
    ..The porcine respiratory CoV (PRCV), a spike deletion mutant of the enteric CoV transmissible gastroenteritis virus (TGEV), shows striking pathogenetic similarities to SARS CoV in its primary replication in lung...
  65. ENHANCING THE IMMUNOGENICITY OF HUMAN ROTAVIRUS VACCINES
    Linda Saif; Fiscal Year: 2006
    Rotaviruses (RV) are the leading cause of severe gastroenteritis in infants and children worldwide. The RV genome consists of 11 segments of dsRNA which encode 6 structural (VP) and 6 non-structural (NSP) viral proteins...
  66. VIRAL PROTEINS IN ROTAVIRUS REPLICATION
    John Patton; Fiscal Year: 1991
    Rotaviruses, members of the family Reoviridae, are the major cause of acute gastroenteritis in young children. Despite the pathogenic importance of these viruses, the basic molecular biology of the rotaviruses is not well understood...
  67. ENTERIC VIRAL INFECTIONS OF CAPTIVE RHESUS MACAQUES
    Karol Sestak; Fiscal Year: 2009
    ..In addition, human caliciviruses are responsible for over 80% of nonbacterial gastroenteritis outbreaks affecting all age groups and up to 20% of sporadic acute gastroenteritis episodes in children...
  68. ANALYSIS TYPHIMURIUM ADHESION TO PEYERS PATCHES
    ANDREAS BAUMLER; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract): Salmonellosis is one of the most common causes of acute gastroenteritis. During this infection, Salmonella enters its host preferentially through the Peyer's patches of the terminal ..
  69. Probiotics for Infectious Diarrhea in Children in South India
    Honorine Ward; Fiscal Year: 2009
    ..Rotavirus and Cryptosporidium spp. are the most important viral and parasitic causes of gastroenteritis in children in south India...
  70. INDO-US Collaboration to Develop Rotavirus Vaccines
    Pratima Ray; Fiscal Year: 2005
    Rotavirus infects all children by 5 years of life, and is the most common cause of severe gastroenteritis worldwide. In the US, rotavirus is a common cause of morbidity, accounting for considerable health-care costs...
  71. Solar Water Disinfection: Randomized Intervention Trial
    JOHN COLFORD; Fiscal Year: 2006
    ..Thus, waterborne gastroenteritis remains a major infrastructural and public health problem particularly, as effective treatment (filtration, ..
  72. Campylobacter colonization and virulence determinants
    Alain Stintzi; Fiscal Year: 2007
    Campylobacter spp, generally food-borne, are the leading cause of gastroenteritis worldwide, surpassing the number of cases of Salmonella and Shigella combined. Campylobacter spp...
  73. Effects of Probiotic Lactobacilli on Rotavirus Immunity
    Lijuan Yuan; Fiscal Year: 2006
    Rotaviruses are the leading cause of severe gastroenteritis in infants and children worldwide...
  74. SALMONELLA ANTIMICROBIAL PEPTIDE RESISTANCE
    John Gunn; Fiscal Year: 2002
    ..Infections by these organisms result in a spectrum of diseases including enteric (typhoid) fever, gastroenteritis and bacteremias...
  75. Elucidation of colonization and virulence through a novel comparative approach
    CHERYL WHISTLER; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The emergent human pathogen Vibrio parahaemolyticus is a major cause of gastroenteritis worldwide...
  76. VIRAL GASTROENTERITIS--BASIS OF PROTECTION AND VIRULENCE
    Harry Greenberg; Fiscal Year: 2003
    ..In order to better understand the molecular and virologic basis of virulence and/or host tropism, we will identify relevant steps in the viral replication cycle in vivo that are restricted on the basis of host range. ..