Genomes and Genes
Summary: INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
Publications339 found, 100 shown here
- A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitisMichael R Konikoff
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Gastroenterology 131:1381-91. 2006Eosinophilic esophagitis is an increasingly recognized disorder with distinctive endoscopic, histologic, and allergic features. Although several therapies are advocated, no placebo-controlled trials have been conducted...
- Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatmentGlenn T Furuta
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
Gastroenterology 133:1342-63. 2007..Subsequent studies demonstrated that these patients had a "new" disease termed eosinophilic esophagitis (EE). As recognition of EE grew, so did confusion surrounding diagnostic criteria and treatment...
- Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, MinnesotaGanapathy A Prasad
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Clin Gastroenterol Hepatol 7:1055-61. 2009Data on secular trends and outcomes of eosinophilic esophagitis (EE) are scarce. We performed a population-based study to assess the epidemiology and outcomes of EE in Olmsted County, Minnesota, over the last 3 decades.
- Gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based studyModh Said Rosaida
Division of Gastroenterology, Dept of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Eur J Gastroenterol Hepatol 16:495-501. 2004..To determine the prevalence of and risk factors for gastro-oesophageal reflux disease (GORD), reflux oesophagitis and non-erosive reflux disease (NERD) amongst Malaysian patients undergoing upper gastrointestinal endoscopic examination...
- Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patientsJeremy R Parfitt
Department of Pathology, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada
Mod Pathol 19:90-6. 2006Eosinophilic esophagitis in adults is a recently described entity occurring in young males with dysphagia, in whom esophageal biopsies show eosinophilic infiltration...
- Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophiliaAnil Mishra
Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Gastroenterology 134:204-14. 2008Eosinophilic esophagitis (EE) is an increasingly recognized disease that mimics gastroesophageal reflux disease. Recently, EE has been associated with esophageal remodeling, but the mechanisms involved are poorly understood...
- Acute esophagitis and late lung toxicity in concurrent chemoradiotherapy trials in patients with locally advanced non-small-cell lung cancer: analysis of the radiation therapy oncology group (RTOG) databaseMaria Werner-Wasik
Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Clin Lung Cancer 12:245-51. 2011We analyzed time course and factors associated with acute esophagitis (ES) and late lung toxicity (PN), as well as any association between ES and PN in patients (pts) with non-small-cell lung cancer (NSCLC) treated with concurrent ..
- Erosive esophagitis is a risk factor for Barrett's esophagus: a community-based endoscopic follow-up studyJukka Ronkainen
Institute of Health Sciences, University of Oulu, Oulu, Finland
Am J Gastroenterol 106:1946-52. 2011..Furthermore, quantifying the risk of incident BE in those with untreated reflux esophagitis has not been possible...
- Abdominal visceral adipose tissue volume is associated with increased risk of erosive esophagitis in men and womenSu Youn Nam
Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea
Gastroenterology 139:1902-1911.e2. 2010Data on the association between erosive esophagitis and obesity are inconsistent because of variations in study populations and methods used to determine obesity.
- Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapyJose Belderbos
Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Radiother Oncol 75:157-64. 2005..To correlate acute esophageal toxicity with dosimetric and clinical parameters for non-small cell lung cancer (NSCLC) patients treated with radiotherapy (RT) alone or with chemo-radiotherapy (CRT)...
- Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese malesToshiaki Gunji
Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan
J Gastroenterol 46:448-55. 2011..We undertook this study, with a large sample size, to investigate risk factors for endoscopic erosive esophagitis by multivariate analysis, including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) as ..
- Seasonal distribution in newly diagnosed cases of eosinophilic esophagitis in adultsCristina Almansa
Division of Gastroenterology, Mayo College of Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA
Am J Gastroenterol 104:828-33. 2009The etiology of eosinophilic esophagitis (EoE) is not well understood. It has been proposed that eosinophils migrate to the esophagus in response to various ingested and inhaled allergens...
- Distal esophagitis in patients with mustard-gas induced chronic coughM Ghanei
Research Center for Chemical Injuries, Baqiyatallah University of Medical Sciences, Tehran, Iran
Dis Esophagus 19:285-8. 2006..Endoscopy and histological studies were carried out to determine the severity of esophagitis in both groups presenting with gastroesophageal reflux...
- Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagusPilar Jimenez
Aragonés Institute of Health Sciences, and Gastroenterology Service, Lozano Blesa University Hospital Clinic, Avenida San Juan Bosco, C Domingo Miral, s n 15 50009 Zaragoza, Spain
World J Gastroenterol 11:2697-703. 2005Experimental studies suggest that free radicals are involved in acid and pepsin-induced damage of esophageal mucosa. The profile and balance between free radicals and antioxidant systems in human esophagitis are unknown.
- Eosinophilic esophagitisRichard J Noel
N Engl J Med 351:940-1. 2004
- Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in childrenElizabeth T Schaefer
Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Division of Pediatric Gastroenterology, Indianapolis, Indiana 46202, USA
Clin Gastroenterol Hepatol 6:165-73. 2008Although eosinophilic esophagitis is recognized increasingly, outcome data guiding therapy are limited...
- Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical factorsIssam El Naqa
Department of Radiation Oncology, Washington University, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 64:1275-86. 2006..Current models are usually oversimplified. We describe alternative methods for building multivariable dose-response models...
- Eosinophilic esophagitis: escalating epidemiology?Alex Straumann
J Allergy Clin Immunol 115:418-9. 2005
- Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalitiesFlorian Rieder
Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio
Gastroenterology 132:154-65. 2007Gastroesophageal reflux disease is a condition frequently associated with esophagitis and motor abnormalities...
- Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 yearsAlex Straumann
Department of Gastroenterology, Kantonsspital, Olten, Switzerland
Gastroenterology 125:1660-9. 2003Primary eosinophilic esophagitis is a chronic, increasingly recognized, interleukin 5-driven inflammatory disorder of the esophagus...
- IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoidsCarine Blanchard
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 120:1292-300. 2007Eosinophilic esophagitis (EE) is an emerging worldwide disease that mimics gastroesophageal reflux disease...
- Molecular pathways: pathogenesis and clinical implications of microbiome alteration in esophagitis and Barrett esophagusLiying Yang
Department of Medicine and Pathology, New York University School of Medicine, New York, New York 10010, USA
Clin Cancer Res 18:2138-44. 2012..metaplasia or Barrett esophagus, which is a response to inflammation of the esophageal squamous mucosa, reflux esophagitis. Gastroesophageal reflux impairs the mucosal barrier in the distal esophagus, allowing chronic exposure of the ..
- Cow's milk protein-induced eosinophilic esophagitis in a child with gluten-sensitive enteropathyAmir F Kagalwalla
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
J Pediatr Gastroenterol Nutr 44:386-8. 2007
- Association between body mass index and erosive esophagitis: a meta-analysisNan Cai
Department of Digestive Endoscopy and Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing 210011, Jiangsu Province, China
World J Gastroenterol 18:2545-53. 2012To conduct a meta-analysis to estimate the determinants of the association between erosive esophagitis (EE) and body mass index (BMI).
- Metabolic syndrome is associated with erosive esophagitisJung Ho Park
Department of Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, South Korea
World J Gastroenterol 14:5442-7. 2008To clarify whether insulin resistance and metabolic syndrome are risk factors for erosive esophagitis.
- Systematic review of dose-volume parameters in the prediction of esophagitis in thoracic radiotherapyJim Rose
Department of Radiation Oncology, Kingston Regional Cancer Centre, ON, Canada
Radiother Oncol 91:282-7. 2009With dose escalation and increasing use of concurrent chemoradiotherapy, radiation esophagitis (RE) remains a common treatment-limiting acute side effect in the treatment of thoracic malignancies...
- Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-upsMotohiko Kato
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
J Gastroenterol 46:1361-7. 2011..Recently, visceral fat has been recognized as an endocrine organ that secretes various adipocytokines including adiponectin. The aim of this study was to elucidate the relation between adiponectin and erosive esophagitis.
- Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux diseaseDavid A Johnson
Eastern Virginia Medical School, Division of Gastroenterology, Norfolk, 23505, USA
Gastroenterology 126:660-4. 2004..of reflux disease, it is unclear whether the severity of heartburn reliably indicates the severity of erosive esophagitis. We therefore assessed the relationship between age, severe heartburn symptoms, and severe erosive esophagitis.
- Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cellsFrancesca Milano
Laboratory of Experimental Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Gastroenterology 132:2412-21. 2007..In this study, the role of the BMP pathway in the metaplastic transformation of normal squamous cells into columnar cells was examined...
- Microscopic esophagitis and Barrett's esophagus: the histology reportRoberto Fiocca
Department of Anatomic Pathology, University of Genova and S Martino University Hospital, Genoa, Italy
Dig Liver Dis 43:S319-30. 2011..This paper details the histological criteria for diagnosing GERD-associated microscopic esophagitis, other forms of esophagitis with specific features and columnar metaplasia in the lower esophagus (Barrett's ..
- Treatment with high-dose proton pump inhibitors helps distinguish eosinophilic esophagitis from noneosinophilic esophagitisWael N Sayej
Digestive Diseases and Nutrition Center, Women and Children s Hospital of Buffalo, University at Buffalo, NY 14222, USA
J Pediatr Gastroenterol Nutr 49:393-9. 2009Eosinophilic esophagitis (EE) is a clinical entity that is recognized increasingly in children. The treatment of EE has been debated since its identification as a clinical entity separate from reflux esophagitis...
- Relating acute esophagitis to radiotherapy dose using FDG-PET in concurrent chemo-radiotherapy for locally advanced non-small cell lung cancerJasper Nijkamp
Department of Radiation Oncoloyg, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Radiother Oncol 106:118-23. 2013To correlate radiotherapy (RT) dose to acute esophagitis (AE) by means of FDG-PET scans acquired after concurrent chemo-radiotherapy (cCRT) for locally advanced non-small-cell lung cancer (NSCLC).
- Common variants at 5q22 associate with pediatric eosinophilic esophagitisMarc E Rothenberg
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Nat Genet 42:289-91. 2010Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of eosinophils in the esophagus...
- Clinical and endoscopic features of eosinophilic esophagitis in adultsJohn Croese
Department of Gastroenterology, The Townsville Hospital, Townsville, Australia
Gastrointest Endosc 58:516-22. 2003Eosinophilic esophagitis in adults is regarded as unusual, being diagnosed mostly in young men presenting with dysphagia. Mucosal furrows are a sentinel endoscopic feature...
- Marked deposition of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitisGail M Kephart
Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Gastroenterol 105:298-307. 2010Eosinophilic esophagitis (EoE) is characterized by infiltration of eosinophils into esophageal epithelium. Blood levels of an eosinophil granule protein, eosinophil-derived neurotoxin (EDN), have been proposed as a biomarker for EoE...
- Radiation-induced esophagitis on FDG PET imagingPeeyush Bhargava
Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Nucl Med 28:849-50. 2003
- Celiac disease and eosinophilic esophagitis: a true associationConnull Leslie
Department of Anatomic Pathology, Princess Margaret Hospital for Children, Subiaco, Australia
J Pediatr Gastroenterol Nutr 50:397-9. 2010Celiac disease (CD) and eosinophilic esophagitis (EE) are distinct disorders with specific clinico-pathological characteristics. Recent reports suggest an association between the 2...
- Biphasic effect of prostaglandin E2 in a rat model of esophagitis mediated by EP1 receptors: relation to pepsin secretionMasanori Yamato
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
Digestion 72:109-18. 2005..using subtype-selective EP agonists and antagonists as well as various COX inhibitors, in an acute rat esophagitis model. The animals were used after fasting for 18 h...
- Involvement of mast cells in eosinophilic esophagitisJ Pablo Abonia
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 126:140-9. 2010Eosinophilic esophagitis (EE) is an emerging disorder with poorly understood pathogenesis.
- Variability in diagnostic criteria for eosinophilic esophagitis: a systematic reviewEvan S Dellon
Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Am J Gastroenterol 102:2300-13. 2007Eosinophilic esophagitis (EoE) is an emerging clinicopathologic entity defined by abnormal esophageal eosinophilic infiltration. Our understanding of this disease is hampered by the lack of a uniform diagnostic standard...
- Gastroesophageal reflux disease--from reflux episodes to mucosal inflammationArne Kandulski
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Leipziger Straβe 44, 39120 Magdeburg, Germany
Nat Rev Gastroenterol Hepatol 9:15-22. 2012..From bench to bedside, these novel molecular findings might provide new treatment options beyond current acid-suppressive therapy and the principle of inhibition of transient lower esophageal sphincter relaxation...
- Prevention of acute radiation-induced esophagitis with glutamine in non-small cell lung cancer patients treated with radiotherapy: evaluation of clinical and dosimetric parametersErkan Topkan
Baskent University Medical Faculty, Adana Medical and Research Center, Department of Radiation Oncology, Kisla Saglik Yerleskesi, 01120 Adana, Turkey
Lung Cancer 63:393-9. 2009..purpose of this study was to evaluate the efficacy of oral glutamine in the prevention of acute radiation-induced esophagitis (ARIE) and weight loss in lung carcinoma patients, and to determine the clinical/dosimetric predictors of ARIE.
- Gene mutations and polymorphisms of TP53 and FHIT in chronic esophagitis and esophageal carcinomaAparecida Perpetuo Fedossi Silveira
Department of Biology, UNESP, Sao Paulo State University, Sao Jose do Rio Preto, SP, Brazil
Anticancer Res 31:1685-90. 2011The aim of this study was to investigate genetic changes of the TP53 (tumor protein p53) and FHIT (fragile histidine triad) genes in precursor lesion such as chronic esophagitis (CE) and in esophageal squamous cell carcinoma (ESCC).
- Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groupsRobert C Kapel
Division of Gastroenterology, Danbury Hospital, Danbury, Connecticut, USA
Gastroenterology 134:1316-21. 2008Most reports on eosinophilic esophagitis (EE) are limited to small series from single institutions. This study describes features of EE in a broader population.
- The natural history of dysplasia and cancer in esophagitis and Barrett esophagusStuart Jon Spechler
Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
J Clin Gastroenterol 36:S2-5; discussion S26-8. 2003..Dysplasia in the metaplastic epithelium clearly is a worrisome finding, but the progression from dysplasia to cancer may take years and may not be inevitable...
- Dosimetric correlates for acute esophagitis in patients treated with radiotherapy for lung carcinomaJeffrey Bradley
Department of Radiation Oncology, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 58:1106-13. 2004Acute esophagitis is a common complication of radiotherapy (RT) for non-small-cell carcinoma of the lung...
- Combination of longitudinal and circumferential three-dimensional esophageal dose distribution predicts acute esophagitis in hypofractionated reirradiation of patients with non-small-cell lung cancer treated in stereotactic body frameIgor M Poltinnikov
Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Int J Radiat Oncol Biol Phys 62:652-8. 2005To evaluate dosimetric predictors of acute esophagitis (AE) and clinical outcome of patients with non-small-cell lung cancer (NSCLC) receiving reirradiation.
- Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in miceAnil Mishra
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, OH 45229, USA
J Leukoc Biol 81:916-24. 2007We have previously developed a murine model of allergen-induced eosinophilic esophagitis (EE), characterized by intraepithelial eosinophils, extracellular granule deposition, and epithelial cell hyperplasia, features that mimic the ..
- Detection of mucosal and cutaneous human papillomaviruses in oesophagitis, squamous cell carcinoma and adenocarcinoma of the oesophagusMaria Lina Tornesello
Molecular Biology and Viral Oncology Unit and AIDS Reference Centre, National Cancer Institute Fond Pascale, Naples, Italy
J Clin Virol 45:28-33. 2009..Still controversial is the association of HPV infection with oesophageal neoplasia...
- Treatment-related pneumonitis and acute esophagitis in non-small-cell lung cancer patients treated with chemotherapy and helical tomotherapyChang Hoon Song
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
Int J Radiat Oncol Biol Phys 78:651-8. 2010..To assess clinical outcomes and complications in patients with non-small-cell lung cancer (NSCLC) treated with helical tomotherapy (HT) with or without chemotherapy...
- An update on the immunopathogenesis of eosinophilic esophagitisAlfredo J Lucendo
Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, S N, 13700 Tomelloso, Spain
Expert Rev Gastroenterol Hepatol 4:141-8. 2010Eosinophilic esophagitis (EoE) is a chronic clinicopathological entity characterized by large numbers of intraepithelial eosinophils infiltrating the esophageal mucosa, which is not caused by gastroesophageal reflux...
- Prevention of radiochemotherapy-induced esophagitis with glutamine: results of a pilot studyManuel Algara
Department of Radiation Oncology, Hospital de l Esperança, Institut Municipal d Assistència Sanitària IMAS, Barcelona, Spain
Int J Radiat Oncol Biol Phys 69:342-9. 2007To assess the usefulness of oral glutamine to prevent radiochemotherapy-induced esophagitis in patients with lung cancer, and to determine the dosimetric parameter predictive of esophagitis.
- Pollen and eosinophilic esophagitisMatthew I Fogg
J Allergy Clin Immunol 112:796-7. 2003
- The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in KoreaN Kim
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Aliment Pharmacol Ther 27:173-85. 2008..Prospective nationwide multicentre studies that have evaluated endoscopic findings and reflux symptoms using a well-designed questionnaire are very rare...
- Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch testsJonathan M Spergel
Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
Ann Allergy Asthma Immunol 95:336-43. 2005Eosinophilic esophagitis (EE) is a recently described disorder identified in patients with symptoms suggestive of gastroesophageal reflux disease (GERD) but unresponsive to conventional reflux therapies...
- Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitisAmir F Kagalwalla
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Clin Gastroenterol Hepatol 4:1097-102. 2006In children, eosinophilic esophagitis (EE) is predominantly, but not exclusively, a food-hypersensitivity disorder...
- Eosinophilic esophagitis: asthma of the esophagus?Amindra S Arora
Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 2:523-30. 2004Eosinophilic esophagitis (EE) is rapidly emerging as a distinct disease entity in both pediatric and adult gastroenterology. The typical clinical presentation includes solid food dysphagia in young men who have an atopic predisposition...
- Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in childrenSeema S Aceves
Division of Allergy and Immunology, Children s Hospital, San Diego, La Jolla, California, USA
Am J Gastroenterol 102:2271-9; quiz 2280. 2007Eosinophilic esophagitis (EE) is a disorder characterized typically by pan-esophageal eosinophilia. We evaluate a palatable, long-acting topical corticosteroid preparation for the treatment of EE.
- A novel histologic scoring system to evaluate mucosal biopsies from patients with eosinophilic esophagitisCheryl Protheroe
Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
Clin Gastroenterol Hepatol 7:749-755.e11. 2009Eosinophilic esophagitis (EoE) is characterized by medically/surgically-resistant gastroesophageal reflux symptoms and dense squamous eosinophilia...
- The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitisJonathan M Spergel
Allergy Section, Division of Immunologic and Infectious Disease, The Children s Hospital of Philadelphia, PA 19104, USA
J Allergy Clin Immunol 109:363-8. 2002Eosinophilic esophagitis is a disease entity in which patients have (1) elevated eosinophils on esophageal biopsy and (2) symptoms of gastroesophageal reflux...
- Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trialRanjan Dohil
Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, California and Rady Children s Hospital San Diego, San Diego, California 92103 8450, USA
Gastroenterology 139:418-29. 2010Eosinophilic esophagitis (EoE) is caused by immunologic reactions to ingested/inhaled allergens. The diagnosis is considered if >or=15 eosinophils per high-powered field (eos/hpf) are detected in mucosal biopsies...
- Ethnic differences in the prevalence of endoscopic esophagitis and Barrett's esophagus: the long and short of it allShanmugarajah Rajendra
Department of Medicine, Perak College of Medicine, Ipoh, Malaysia
Dig Dis Sci 49:237-42. 2004..The prevalence of erosive esophagitis and Barrett's esophagus in a multiethnic Malaysian population was studied, as well as the relationship of ..
- Eosinophilic esophagitis in adults: an emerging problem with unique esophageal featuresJon W Potter
Division of Gastroenterology and Hepatology, Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Gastrointest Endosc 59:355-61. 2004Eosinophilic esophagitis is an inflammatory condition in which there is dense eosinophilic infiltration of the surface lining of the esophagus. Reports of eosinophilic esophagitis pertain almost exclusively to pediatric populations...
- A randomized double-blind study of caspofungin versus amphotericin for the treatment of candidal esophagitisA Villanueva
Universidad de Antioquia, Medellin, Colombia
Clin Infect Dis 33:1529-35. 2001..of caspofungin relative to amphotericin B in adults with endoscopically documented symptomatic Candida esophagitis. By use of a modified intent-to-treat analysis, endoscopically verified clinical success was achieved in 74% (..
- Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitisCarine Blanchard
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Immunol 184:4033-41. 2010We have previously proposed that the pathogenesis of eosinophilic esophagitis (EE) is mediated by an IL-13-driven epithelial cell response associated with marked gene dysregulation including eotaxin-3 overproduction...
- Proinflammatory cytokines alter/reduce esophageal circular muscle contraction in experimental cat esophagitisWeibiao Cao
Department of Medicine, Rhode Island Hospital and Brown University, 593 Eddy St, Providence, RI 02903, USA
Am J Physiol Gastrointest Liver Physiol 287:G1131-9. 2004..After induction of experimental esophagitis by repeated acid perfusion, the responses to swallowing and to EFS were significantly reduced but contraction ..
- Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitisSteve Hernandez
Department of Medicine, Division Infectious Diseases 7881, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Antimicrob Agents Chemother 48:1382-3. 2004A patient with azole-refractory thrush-esophagitis responded initially to caspofungin, but the treatment eventually failed...
- Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complicationsHoward Hampel
Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
Ann Intern Med 143:199-211. 2005The association of body mass index and gastroesophageal reflux disease (GERD), including its complications (esophagitis, Barrett esophagus, and esophageal adenocarcinoma), is unclear.
- Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanismAnil Mishra
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Gastroenterology 125:1419-27. 2003..that simultaneous delivery of allergen to the lung and gastrointestinal tract induces experimental eosinophilic esophagitis (EE)...
- Predictors of radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with three-dimensional conformal radiotherapyAnurag K Singh
Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 55:337-41. 2003....
- Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescentsJonathan E Markowitz
Divisions of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Am J Gastroenterol 98:777-82. 2003Eosinophilic esophagitis (EoE), a disorder characterized by eosinophilic infiltration of the esophageal mucosa, has been defined in large part through published case reports and series leading to ambiguity in both diagnostic and ..
- Eosinophilic esophagitis: a 10-year experience in 381 childrenChris A Liacouras
Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Clin Gastroenterol Hepatol 3:1198-206. 2005Eosinophilic esophagitis (EoE) is a disorder characterized by a severe, isolated eosinophilic infiltration of the esophagus unresponsive to aggressive acid blockade but responsive to the removal of dietary antigens...
- Eosinophilic esophagitis: it's not just kid's stuffVictor L Fox
Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Gastrointest Endosc 56:260-70. 2002
- Eosinophilic esophagitis in children with celiac diseaseChee Y Ooi
Department of Gastroenterology, Sydney Children s Hospital, Randwick, NSW, Australia
J Gastroenterol Hepatol 23:1144-8. 2008Eosinophilic esophagitis and celiac disease are distinct gastrointestinal disorders. The present study in children highlights the possible coexistence of these two conditions...
- Comparison of inter- and intraobserver consistency for grading of esophagitis by expert and trainee endoscopistsJohn E Pandolfino
Northwestern University Medical School, Chicago, Illinois 60611, USA
Gastrointest Endosc 56:639-43. 2002This study evaluated intra- and interobserver variability in the endoscopic scoring of esophagitis by using two grading schemes, the Los Angeles and Hetzel-Dent scales.
- The association between obesity and GERD: a review of the epidemiological evidenceHashem El-Serag
The Sections of Gastroenterology and Health Services Research, The Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
Dig Dis Sci 53:2307-12. 2008..GERD and some of its complications, including a generally consistent association with GERD symptoms, erosive esophagitis, and esophageal adenocarcinoma...
- Effect of Helicobacter pylori eradication on development of erosive esophagitis and gastroesophageal reflux disease symptoms: a post hoc analysis of eight double blind prospective studiesLoren Laine
Department of Medicine, University of Southern California School of Medicine, Los Angeles, California 90033, USA
Am J Gastroenterol 97:2992-7. 2002The aim of this study was to assess the development of erosive esophagitis, the development of gastroesophageal reflux disease (GERD) symptoms in patients without prior symptomatic or endoscopic GERD, and the worsening of GERD symptoms ..
- High-resolution EUS in children with eosinophilic "allergic" esophagitisVictor L Fox
Division of Gastroenterology and Nutrition, Department of Pediatrics, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Gastrointest Endosc 57:30-6. 2003The pathophysiology of dysphagia associated with eosinophilic esophagitis is unknown...
- Eosinophilic esophagitisJonathan E Markowitz
Division of Gastroenterology and Nutrition, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
Gastroenterol Clin North Am 32:949-66. 2003..These reviews coupled with the past reports and increasing incidence of EoE provide a sound background for further research on the etiology, epidemiology and treatment of EoE...
- Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseasesDagmar Simon
J Allergy Clin Immunol 115:1090-2. 2005
- p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas diseaseMarilanda Ferreira Bellini
Department of Biology, UNESP, Sao Paulo State University, Campus São José do Rio Preto, SP, Brazil
Anticancer Res 28:3793-9. 2008Models have suggested esophageal carcinogenesis can result from the alteration of sequences, leading to esophagitis, atrophy, dysplasia, carcinoma in situ and invasive carcinoma...
- Is there a seasonal variation in the incidence or intensity of allergic eosinophilic esophagitis in newly diagnosed children?Flint Y Wang
Division of Pediatric Gastroenterology, Hepatology and Nutrition, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Clin Gastroenterol 41:451-3. 2007Allergic eosinophilic esophagitis (AEE) is thought to be an allergic reaction that is characterized by inflammation caused by predominant accumulation of eosinophils in esophageal mucosa (> or =15 eosinophils per high power field).
- Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitisAlex Straumann
Department of Gastroenterology, University Hospital Basel, Basel, Switzerland
Gastroenterology 139:1526-37, 1537.e1. 2010Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by dense tissue eosinophilia; it is refractory to proton pump inhibitor therapy...
- The role of allergy evaluation in adults with eosinophilic esophagitisJoshua D Penfield
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Clin Gastroenterol 44:22-7. 2010Allergy evaluation and skin prick testing for foods are recommended in all patients with eosinophilic esophagitis. However, the yield of allergy evaluation in adult eosinophilic esophagitis is not known.
- Patient and caregiver perspective on pediatric eosinophilic esophagitis and newly developed symptom questionnaires*Emuella M Flood
Oxford Outcomes Inc, Bethesda, MD 20814, USA
Curr Med Res Opin 24:3369-81. 2008Eosinophilic esophagitis (EE), a rare chronic inflammatory condition of the esophagus, is predominantly observed in children and is primarily manifested with feeding difficulties...
- Esophageal subepithelial fibrosis in children with eosinophilic esophagitisMirna Chehade
Department of Pediatric Gastroenterology and Nutrition, Mount Sinai School of Medicine, New York, NY 10029, USA
J Pediatr Gastroenterol Nutr 45:319-28. 2007Esophageal subepithelial fibrosis has been reported in adults with eosinophilic esophagitis (EE)...
- Activated mucosal mast cells differentiate eosinophilic (allergic) esophagitis from gastroesophageal reflux diseaseRichard Kirsch
Division of Pathology, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
J Pediatr Gastroenterol Nutr 44:20-6. 2007To evaluate the utility of activated mucosal mast cells (MC) in the differential diagnosis of eosinophilic esophagitis (EE) and gastroesophageal reflux disease (GERD).
- Eosinophilic esophagitisAnand R Gupte
Department of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida 32610, USA
World J Gastroenterol 15:17-24. 2009Eosinophilic esophagitis is increasingly recognized in adults. The diagnosis is based on the presence of both typical symptoms and pathologic findings on esophageal biopsy...
- Predictive values for skin prick test and atopy patch test for eosinophilic esophagitisJonathan M Spergel
J Allergy Clin Immunol 119:509-11. 2007
- Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitisJoseph D Sherrill
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 126:160-5.e3. 2010The genetic cause of eosinophilic esophagitis (EE) has been largely unexplored until a recent genome-wide association study identified a disease susceptibility locus on 5q22, a region that harbors the thymic stromal lymphopoietin (TSLP) ..
- Pediatric patients with eosinophilic esophagitis: an 8-year follow-upAmal H Assa'ad
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Allergy Clin Immunol 119:731-8. 2007Eosinophilic esophagitis (EE) is a gastrointestinal disorder that is increasingly diagnosed in pediatric patients.
- Primary eosinophilic esophagitisV Munitiz
Department of Surgery, Virgen de la Arrixaca University Hospital Murcia, Spain
Dis Esophagus 16:165-8. 2003Eosinophilic esophagitis is an uncommon pathology that generally affects children with a history of allergies and intrinsic asthma...
- The Los Angeles and Savary-Miller systems for grading esophagitis: utilization and correlation with histologyR M Genta
Department of Gastrointestinal Pathology, Caris Research Institute, Irving, Texas, USA
Dis Esophagus 24:10-7. 2011..the proportion of patients who have esophageal biopsy specimens taken for an endoscopic diagnosis of reflux esophagitis in which an endoscopic grade of esophagitis (Los Angeles [LA] or Savary-Miller [SM]) is communicated to the ..
- Atypical croup: association with airway lesions, atopy, and esophagitisTimothy Cooper
Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
Otolaryngol Head Neck Surg 147:209-14. 2012..To report on airway endoscopic findings and gastrointestinal and atopic conditions in a large consecutive series of atypical croup...
- Noninvasive markers of eosinophilic esophagitisSandeep K Gupta
Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, ROC 4210, Indianapolis, IN 46202, USA
Gastrointest Endosc Clin N Am 18:157-67; xi. 2008There has been an increasing awareness and recognition of eosinophilic esophagitis (EE), a chronic condition with periods of exacerbation and remission, over the last decade...
- The prevalence of Barrett's esophagus and erosive esophagitis in patients undergoing upper endoscopy for dyspepsia in a VA populationMichael J Connor
Division of Gastroenterology, Department of Preventive Medicine and Public Health and Kansas Cancer Institute, University of Kansas and Veterans Affairs Medical Center, Kansas City, Missouri, USA
Dig Dis Sci 49:920-4. 2004The purpose of this study was to establish the prevalence of Barrett's esophagus and erosive esophagitis in a group of patients undergoing upper endoscopy for dyspepsia...
- Recurring Candida albicans esophagitis in a HIV-infected patient undergoing long-Term antiretroviral therapy, and with absent-negligible immunodeficiencyRoberto Manfredi
Division of Infectious Diseases, Department of Clinical and Experimental Medicine, S Orsola Malpighi Hospital, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Braz J Infect Dis 11:605-9. 2007A patient with HIV infection developed the first episode of AIDS-defining opportunism (severe Candida albicans esophagitis) with an underlying CD4+ lymphocyte count of 1,025 cells/microL...
- Erosive esophagitis after bariatric surgery: banded vertical gastrectomy versus banded Roux-en-Y gastric bypassGustavo Peixoto Soares Miguel
Federal University of Espírito Santo UFES, Vitoria, ES, Brazil
Obes Surg 21:167-72. 2011..The aim of this study was to compare the evolution of erosive esophagitis (EE) in patients who underwent Silastic® ring gastric bypass (SRGB) and Silastic® ring sleeve gastrectomy (..
- Heartburn severity does not predict disease severity in patients with erosive esophagitisM Brian Fennerty
Division of Gastroenterology, Oregon Health and Science University, Portland, Oregon, USA
MedGenMed 8:6. 2006For patients with gastroesophageal reflux disease (GERD), it is often assumed by treating physicians that the severity of heartburn correlates with the severity of erosive esophagitis (EE).
- Simultaneous herpes simplex virus esophagitis and lupus enteritis in a patient with systemic lupus erythematosusHideki Wakui
Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
Mod Rheumatol 20:98-101. 2010..Herpes simplex virus (HSV) esophagitis and lupus enteritis were diagnosed on the basis of the results of endoscopic and histological examinations and ..
- Drug-induced esophagitisG N Zografos
Department of Sugery, Athens General Hospital, Athens, Greece
Dis Esophagus 22:633-7. 2009Drug-induced esophagitis is being recognized increasingly in the past few years. Since 1970 more than 650 cases have been reported worldwide caused by 30 or more medications...
- The Prevalence of Barrett's Esophagus in Patients with *Blair Jobe; Fiscal Year: 2004..Substantial published data support a causal relation between complicated GERD (esophagitis and Barrett's metaplasia) and extraesophageal reflux symptoms...
- Targeting Siglec-8/-F to treat eosinophil and mast cell related disordersBruce S Bochner; Fiscal Year: 2013..Eosinophils and mast cells are implicated in other chronic diseases including eosinophilic esophagitis. Systemic Mastocytosis, a malignant disease, presents with varying prognoses depending on the extent of ..
- Targeting Siglec-8/-F to treat eosinophil and mast cell related disordersBruce S Bochner; Fiscal Year: 2012..Eosinophils and mast cells are implicated in other chronic diseases including eosinophilic esophagitis. Systemic Mastocytosis, a malignant disease, presents with varying prognoses depending on the extent of ..
- Mouse models for esophageal Cox-2 oxidative stress and DNA damageJohn P Lynch; Fiscal Year: 2013..We therefore hypothesize that Cox-2 expression in the murine esophagus results in a chronic esophagitis that models GERD esophagitis by provoking oxidative stress, DNA damage, and the development of metaplasia and ..
- Modeling oxidative stress and DNA damage using GI organotypic culture systemsJohn P Lynch; Fiscal Year: 2013..pursuing the following Specific Aims: 1) Adapt the esophageal organotypic culture system to better model GERD esophagitis and progression of stem cells to metaplasia and dysplasia...
- Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and BoneYu Xiao Yang; Fiscal Year: 2013..common for patients to take these potent acid suppressants on a long-term and continuous basis for erosive esophagitis, Barrett's esophagus and protection against nonsteroidal anti-inflammatory drug-related gastropathy...
- Targeting the DNA damage response pathway for the treatment of HSV esophagitisOleg Alekseev; Fiscal Year: 2013..The estimates of the incidence of herpes esophagitis vary widely, with some studies reporting as much as 15% of transplant recipients testing positive...
- Patient research in eosinophilic gastrointestinal diseasesGlenn T Furuta; Fiscal Year: 2013..an increasing incidence estimated at 4 in 10,000, diagnostic criteria for one type of EGID, eosinophilic esophagitis (EoE), has only recently been defined...
- Role of Acid in the Development of Barrett's EsophagusStuart Jon Spechler; Fiscal Year: 2013..In a rat model of reflux esophagitis in which an esophago-duodenostomy is created to induce reflux, we recently studied the early histological ..
- Investigation of the Role of TGF Beta in TH2-Mediated DiseasePAMELA ANN GUERRERIO; Fiscal Year: 2013..LDS appears to be the first Mendelian disorder associated with the development of food allergy and eosinophilic esophagitis, and offers an unparalleled opportunity to study the role of TGF-[unreadable] in the human immune system...
- Mechanisms of tissue damage leading to chronic allergic eosinophilic esophagitisSeema S Aceves; Fiscal Year: 2013DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EE) is a chronic allergic disease of increasing prevalence diagnosed as an acid- independent esophageal eosinophilia of >15 per high power field...
- Toll-like Receptor Signaling in the Esophageal EpitheliumMei Lun Wang; Fiscal Year: 2013..In addition to its significant socioeconomic burden, longstanding GERD esophagitis is a risk factor for Barrett's esophagus, a premalignant condition associated with the development of ..
- Normal Tissue Complication Modeling for RadiotherapyJoseph Deasy; Fiscal Year: 2009..Under SA #2, Improvements in acute esophagitis NTCP models, we will: (a) accrue more patients (from 166 to an estimated 450 in 4 years), (b) incorporate new ..
- The Role of Periostin and Th2 Cytokines in Eosinophilic Esophagitis FibrogenesisEdaire Cheng; Fiscal Year: 2013..and funded physician-scientist with a research focus on fibrogenesis and tissue remodeling in eosinophilic esophagitis (EoE)...
- Risk Factors and Biomarkers for Diagnosis &Treatment of Eosinophilic EsophagitisEVAN SAMUEL DELLON; Fiscal Year: 2013..research methodology, and a proven commitment to the study of esophageal diseases, and eosinophilic esophagitis (EoE) in particular...
- The role of iNKTs in eosinophilic esophagitis.Antonella Cianferoni; Fiscal Year: 2013..Pediatric FA affects 6-8% of children, in whom it is the major risk factor for anaphylaxis and eosinophilic esophagitis (EoE)...
- Role of IL-6/STAT3 Signaling in the Neoplastic Progression of Barrett's EsophagusRhonda F Souza; Fiscal Year: 2013..cancer that can be established through two pathways: 1) an extrinsic pathway in which disorders such as reflux esophagitis cause tissue inflammation that contributes to carcinogenesis, and 2) an intrinsic pathway in which the ..
- REGULATION OF GASTROINTESTINAL EOSINOPHILSMarc E Rothenberg; Fiscal Year: 2013DESCRIPTION (provided by applicant): Eosinophilic gastrointestinal disorders (EGID) (i.e. eosinophilic esophagitis [EE]) are being increasingly recognized over the last decade yet they have been greatly understudied compared with other ..
- THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASEPeter James Kahrilas; Fiscal Year: 2013..This can cause esophagitis or a host of nonspecific symptoms...
- Transnasal Probe for Diagnosing Eosinophilic EsophagitisGuillermo J Tearney; Fiscal Year: 2013DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EoE) is an inflammatory condition of the esophagus, thought to be caused by food allergy, and characterized by the presence of eosinophils within the esophageal mucosa...
- Foregut microbiome in development of esophageal adenocarcinomaZhiheng Pei; Fiscal Year: 2012..EA is the end result of a sequence of GERD-related diseases, preceded by reflux esophagitis (RE) and Barrett's esophagus (BE)...
- Phase 2 Study of Esophageal String Test in Diagnosing Eosinophilic EsophagitisGlenn T Furuta; Fiscal Year: 2013PROJECT SUMMARY Eosinophilic esophagitis (EoE) is an increasingly recognized rare disease of children and adults characterized by symptoms including nausea, vomiting, abdominal pain, dysphagia and food impaction that occur in ..
- The Influence of Hospital Variability on the Management of Cancer-Associated CompJason Wright; Fiscal Year: 2013..hospitalized patients admitted with a primary diagnosis of: febrile neutropenia, hypercalcemia of malignancy, esophagitis, and acute cancer-associated pain...
- ESOPHAGEAL CYTOPROTECTION--AGENTS AND MECHANISMSRoy Orlando; Fiscal Year: 2009The long term goal of this proposal is to understand the pathogenesis of the human disease, reflux esophagitis (RE), and this approached mechanistically and from the relatively uncommon vantage point of the target tissue, the esophageal ..
- A multi-center clinical trial of 1760 mcg of daily swallowed fluticasone vs. placMarc E Rothenberg; Fiscal Year: 2010Eosinophilic esophagitis (EE) is an emerging vyorldwide disease that mimics gastroesophageal reflux disease (GERD) and can lead to esophageal narrowing and stricture (1-4)...
- Cytokine regulation of human basophil responsesElia D Tait Wojno; Fiscal Year: 2013..express the TSLP receptor (TSLPR), and that basophils isolated from patients suffering from eosinophilic esophagitis (EoE) are more likely to express the IL-33R...
- Epithelial Genes In Allergic InflammationGurjit K Khurana Hershey; Fiscal Year: 2013..e. lung (asthma), skin (atopic dermatitis), or gut (food allergy or eosinophilic esophagitis)...
- Comparative Effectiveness of endoscopic assessment of GER and BEPrasad G Iyer; Fiscal Year: 2012..Subaim 2b: To compare the rates of detection of esophageal injury (esophagitis, strictures and BE) between cohorts stratified by presence/absence of GER symptoms using a validated symptom ..
- ESOPHAGEAL MOTOR FUNCTION IN HEALTH AND DISEASEREZA NONE SHAKER; Fiscal Year: 2013..We have focused these studies on two animal models;repeated acid exposure and chronic erosive esophagitis. These resemble non-erosive and erosive reflux in humans...
- Immunobiology of Food Allergy and Its TreatmentHugh Sampson; Fiscal Year: 2013..The prevalence of peanut allergy in children has doubled since the mid-1990's, and eosinophilic esophagitis (EE), largely food-related in children, has also markedly increased in prevalence...
- IGF::OT::IGF R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH) A NOVEL AGENT THAT REDUCEJeffery Fairman; Fiscal Year: 2013..transgene expressing human superoxide dismutase 2 (SOD2) (JVRSOD) protects the esophagus from radiation-induced esophagitis (a form of mucositis) in mice...
- Novel minimally invasive assessment of gastrointestinal inflammation in food alleGlenn Furuta; Fiscal Year: 2009DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EE) is an increasingly recognized gastrointestinal disease that accounts for ~50% of pediatric and adult cases of dysphagia and food impaction...
- Mechanistic Analysis of Eosinophilic Esophagitis.Anil Mishra; Fiscal Year: 2013..Our studies are timely given the recent attention that EE is receiving in the medical community. ..
- Ulcerative Colitis - Regulation of the IL-13 Receptor SystemPeter Mannon; Fiscal Year: 2013..The results will be applicable to other mucosal inflammatory diseases like allergic asthma and eosinophilic esophagitis where IL-13 also drives disease and new therapies targeting IL-13 are needed.
- Regulation of Allergic Inflammation by HistaminePaul J Bryce; Fiscal Year: 2013..Specific Aim 3 will examine histamine-associated gene patterns in the pathogenesis of eosinophilic esophagitis and build on our existing work demonstrating the mast cells and histamine are important in this disease.
- Maturational Characterization of Human Esophageal Fibroblasts in EoEAMANDA BROOKE MUIR; Fiscal Year: 2013DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EoE) is an allergic disease characterized by esophageal infiltration of eosinophils, diagnosed from childhood through adulthood...
- Foregut microbiome in development of esophageal adenocarcinomaZhiheng Pei; Fiscal Year: 2009..EA is the end result of a sequence of GERD-related diseases, preceded by reflux esophagitis (RE) and Barrett's esophagus (BE)...
- Patient Oriented Research in Pediatric Motility and Related DisordersSamuel Nurko; Fiscal Year: 2013..This project is focused on finding new biomarkers for the evaluation of children with eosinophilic esophagitis. Trainees interested in pediatric motility and related disorders will be encouraged to become directly involved ..
- Urinary Metabolites in Eosinophilic EsophagitisGlenn R Gourley; Fiscal Year: 2013DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EoE), a rapidly emerging allergic disease affecting all ages, presents with esophageal food impaction, dysphagia, growth problems, and esophageal stricturing...
- THE DIAPHRAGM--AN EXTERNAL LOWER ESOPHAGEAL SPHINCTERRAVINDER MITTAL; Fiscal Year: 1993..in relation to its sphincteric function, 4) sphincteric function of the diaphragm in patients with reflux esophagitis, and 5) the primary abnormality in patients with achalasia of the esophagus is it the diaphragm or the LES? We ..
- Influence of acid reflux on stromal epithelial interaction in Barrett?s esophagusGANAPATHY PRASAD; Fiscal Year: 2009..Patients will then be divided into Group A (GER): with acid reflux (characterized by either presence of esophagitis (as determined by the Los Angeles classification) 10 on endoscopy, and/or a positive pH study defined by ..
- NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinomaWeibiao Cao; Fiscal Year: 2007..of GERD patients develop Barrett's esophagus (BE) where esophageal squamous epithelium damaged by reflux esophagitis is replaced by a metaplastic, intestinal- type epithelium...
- Genetic Linkage Analysis of Barrett's EsophagusYvonne Romero; Fiscal Year: 2005..of Barrett's probands without frequent gastroesophageal reflux symptoms are 4-fold more likely to have erosive esophagitis compared to non-symptomatic controls; 2) Twin studies showing the heritable attributable risk of GERD symptoms ..
- Role of H. Pylori Infection in Esophageal AdenocarcinomaKam Meng Tchou Wong; Fiscal Year: 2003..Colonization with cagA+ strains has been shown to be inversely associated with reflux esophagitis and Barrett's esophagus...
- PHARYNGEAL RECEPTORS AND REFLUX DISEASERAVINDER MITTAL; Fiscal Year: 2001..Effects of atropine on the frequency of TLESR and GER in patients with reflux esophagitis.
- ESOPHAGO-LARYNGEAL ADDUCTOR REFLEXNancy Bauman; Fiscal Year: 2000..5. To determine if esophageal acidification induces the ELAR in immature canines with acute esophagitis. These specific aims will be explored in immature canines by applying 0...
- Molecular epidemiology of Barretts esophagus and cancerDavid Whiteman; Fiscal Year: 2006..we aim to quantify the risks associated with exposure to epidemiologic and genetic risk factors for reflux esophagitis (RE), BE and AC...
- NOVEL PROTEIN KINASE IN DIGESTIVE ENZYME SECRETIONLaura Tang; Fiscal Year: 1999..process of the gastrointestinal tract and is considered to contribute to pathological processes such as reflux esophagitis, peptic ulcer disease and pancreatitis...
- GENETIC EPIDEMIOLOGY OF BARRETT'S ESOPHAGUSYvonne Romero; Fiscal Year: 2005..symptoms in families of probands with Barrett's esophagus and esophageal adenocarcinoma (but not solo reflux esophagitis), was published in Gastroenterology in 1997. In the Barrett's Esophagus Genomic Study, for which Dr...
- Genetics of Eosinophilic EsophagitisNing Wang; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EE) is an emerging worldwide disease characterized by the accumulation of eosinophils in the esophagus...
- ESOPHAGEAL CLEARANCE IN HEALTH & DISEASEJames Helm; Fiscal Year: 1991..clearance in health and disease with a special emphasis on its role as an important defense against reflux esophagitis. The aim of this grant will be achieved by pursuing three interrelated objectives: 1) Investigate the ..
- iNOS, COX-2, and Arginase in Murine Barrett's EsophagusKeith Wilson; Fiscal Year: 2003..We will study macroscopic and histologic evidence of esophagitis, BE and BAA, gene expression, apoptosis and proliferation in A. wild-type (WT) vs. COX-2-/- mice, B. W'I- vs...
- TSG6 in IgE mediated Food AllergyCarine Blanchard; Fiscal Year: 2009..time, we also discovered that TSG6 mRNA was upregulated in a human food allergy related disease, eosinophilic esophagitis (EE) (2)...
- CANDIDA DIMORPHISM--VIRULENCE & IMMUNOMODULATORY ACTIONThomas Rogers; Fiscal Year: 1992..Patients with Acquired Immune Deficiency Syndrome (AIDS) frequently develop severe candidal esophagitis. Patients receiving chemotherapy are also at increased risk for invasive candidiasis...
- Pimecrolius on T cell Responses in Atopic MarchJonathan Spergel; Fiscal Year: 2008..In third aim of the trial, we explore the effects of pimecrolimus as a disease-modifying agent in the prevention of asthma. Asthma phenotype will be examined by spirometry per and post-beta-2-agonist and exhaled nitric oxide. ..
- Gene Expression in Barrett's EsophagusHashem El Serag; Fiscal Year: 2006..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
- Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransHashem El Serag; Fiscal Year: 2009..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..