esophagitis

Summary

Summary: INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.

Top Publications

  1. ncbi A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis
    Michael R Konikoff
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 131:1381-91. 2006
  2. ncbi Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment
    Glenn T Furuta
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
    Gastroenterology 133:1342-63. 2007
  3. pmc Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota
    Ganapathy A Prasad
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 7:1055-61. 2009
  4. ncbi Gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based study
    Modh Said Rosaida
    Division of Gastroenterology, Dept of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Eur J Gastroenterol Hepatol 16:495-501. 2004
  5. ncbi Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients
    Jeremy R Parfitt
    Department of Pathology, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada
    Mod Pathol 19:90-6. 2006
  6. pmc Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia
    Anil Mishra
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 134:204-14. 2008
  7. ncbi Acute esophagitis and late lung toxicity in concurrent chemoradiotherapy trials in patients with locally advanced non-small-cell lung cancer: analysis of the radiation therapy oncology group (RTOG) database
    Maria Werner-Wasik
    Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Clin Lung Cancer 12:245-51. 2011
  8. ncbi Erosive esophagitis is a risk factor for Barrett's esophagus: a community-based endoscopic follow-up study
    Jukka Ronkainen
    Institute of Health Sciences, University of Oulu, Oulu, Finland
    Am J Gastroenterol 106:1946-52. 2011
  9. ncbi Abdominal visceral adipose tissue volume is associated with increased risk of erosive esophagitis in men and women
    Su Youn Nam
    Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea
    Gastroenterology 139:1902-1911.e2. 2010
  10. ncbi Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapy
    Jose Belderbos
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Radiother Oncol 75:157-64. 2005

Detail Information

Publications339 found, 100 shown here

  1. ncbi A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis
    Michael R Konikoff
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 131:1381-91. 2006
    Eosinophilic esophagitis is an increasingly recognized disorder with distinctive endoscopic, histologic, and allergic features. Although several therapies are advocated, no placebo-controlled trials have been conducted...
  2. ncbi Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment
    Glenn T Furuta
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, University of Colorado Medical School, Denver, Colorado, USA
    Gastroenterology 133:1342-63. 2007
    ..Subsequent studies demonstrated that these patients had a "new" disease termed eosinophilic esophagitis (EE). As recognition of EE grew, so did confusion surrounding diagnostic criteria and treatment...
  3. pmc Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota
    Ganapathy A Prasad
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 7:1055-61. 2009
    Data on secular trends and outcomes of eosinophilic esophagitis (EE) are scarce. We performed a population-based study to assess the epidemiology and outcomes of EE in Olmsted County, Minnesota, over the last 3 decades.
  4. ncbi Gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based study
    Modh Said Rosaida
    Division of Gastroenterology, Dept of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Eur J Gastroenterol Hepatol 16:495-501. 2004
    ..To determine the prevalence of and risk factors for gastro-oesophageal reflux disease (GORD), reflux oesophagitis and non-erosive reflux disease (NERD) amongst Malaysian patients undergoing upper gastrointestinal endoscopic examination...
  5. ncbi Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients
    Jeremy R Parfitt
    Department of Pathology, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada
    Mod Pathol 19:90-6. 2006
    Eosinophilic esophagitis in adults is a recently described entity occurring in young males with dysphagia, in whom esophageal biopsies show eosinophilic infiltration...
  6. pmc Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia
    Anil Mishra
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 134:204-14. 2008
    Eosinophilic esophagitis (EE) is an increasingly recognized disease that mimics gastroesophageal reflux disease. Recently, EE has been associated with esophageal remodeling, but the mechanisms involved are poorly understood...
  7. ncbi Acute esophagitis and late lung toxicity in concurrent chemoradiotherapy trials in patients with locally advanced non-small-cell lung cancer: analysis of the radiation therapy oncology group (RTOG) database
    Maria Werner-Wasik
    Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Clin Lung Cancer 12:245-51. 2011
    We analyzed time course and factors associated with acute esophagitis (ES) and late lung toxicity (PN), as well as any association between ES and PN in patients (pts) with non-small-cell lung cancer (NSCLC) treated with concurrent ..
  8. ncbi Erosive esophagitis is a risk factor for Barrett's esophagus: a community-based endoscopic follow-up study
    Jukka Ronkainen
    Institute of Health Sciences, University of Oulu, Oulu, Finland
    Am J Gastroenterol 106:1946-52. 2011
    ..Furthermore, quantifying the risk of incident BE in those with untreated reflux esophagitis has not been possible...
  9. ncbi Abdominal visceral adipose tissue volume is associated with increased risk of erosive esophagitis in men and women
    Su Youn Nam
    Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea
    Gastroenterology 139:1902-1911.e2. 2010
    Data on the association between erosive esophagitis and obesity are inconsistent because of variations in study populations and methods used to determine obesity.
  10. ncbi Acute esophageal toxicity in non-small cell lung cancer patients after high dose conformal radiotherapy
    Jose Belderbos
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Radiother Oncol 75:157-64. 2005
    ..To correlate acute esophageal toxicity with dosimetric and clinical parameters for non-small cell lung cancer (NSCLC) patients treated with radiotherapy (RT) alone or with chemo-radiotherapy (CRT)...
  11. ncbi Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males
    Toshiaki Gunji
    Center for Preventive Medicine, Kanto Medical Center, NTT East, Tokyo, Japan
    J Gastroenterol 46:448-55. 2011
    ..We undertook this study, with a large sample size, to investigate risk factors for endoscopic erosive esophagitis by multivariate analysis, including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) as ..
  12. ncbi Seasonal distribution in newly diagnosed cases of eosinophilic esophagitis in adults
    Cristina Almansa
    Division of Gastroenterology, Mayo College of Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA
    Am J Gastroenterol 104:828-33. 2009
    The etiology of eosinophilic esophagitis (EoE) is not well understood. It has been proposed that eosinophils migrate to the esophagus in response to various ingested and inhaled allergens...
  13. ncbi Distal esophagitis in patients with mustard-gas induced chronic cough
    M Ghanei
    Research Center for Chemical Injuries, Baqiyatallah University of Medical Sciences, Tehran, Iran
    Dis Esophagus 19:285-8. 2006
    ..Endoscopy and histological studies were carried out to determine the severity of esophagitis in both groups presenting with gastroesophageal reflux...
  14. ncbi Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus
    Pilar Jimenez
    Aragonés Institute of Health Sciences, and Gastroenterology Service, Lozano Blesa University Hospital Clinic, Avenida San Juan Bosco, C Domingo Miral, s n 15 50009 Zaragoza, Spain
    World J Gastroenterol 11:2697-703. 2005
    Experimental studies suggest that free radicals are involved in acid and pepsin-induced damage of esophageal mucosa. The profile and balance between free radicals and antioxidant systems in human esophagitis are unknown.
  15. ncbi Eosinophilic esophagitis
    Richard J Noel
    N Engl J Med 351:940-1. 2004
  16. ncbi Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children
    Elizabeth T Schaefer
    Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Division of Pediatric Gastroenterology, Indianapolis, Indiana 46202, USA
    Clin Gastroenterol Hepatol 6:165-73. 2008
    Although eosinophilic esophagitis is recognized increasingly, outcome data guiding therapy are limited...
  17. ncbi Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical factors
    Issam El Naqa
    Department of Radiation Oncology, Washington University, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 64:1275-86. 2006
    ..Current models are usually oversimplified. We describe alternative methods for building multivariable dose-response models...
  18. ncbi Eosinophilic esophagitis: escalating epidemiology?
    Alex Straumann
    J Allergy Clin Immunol 115:418-9. 2005
  19. ncbi Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities
    Florian Rieder
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio
    Gastroenterology 132:154-65. 2007
    Gastroesophageal reflux disease is a condition frequently associated with esophagitis and motor abnormalities...
  20. ncbi Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years
    Alex Straumann
    Department of Gastroenterology, Kantonsspital, Olten, Switzerland
    Gastroenterology 125:1660-9. 2003
    Primary eosinophilic esophagitis is a chronic, increasingly recognized, interleukin 5-driven inflammatory disorder of the esophagus...
  21. ncbi IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 120:1292-300. 2007
    Eosinophilic esophagitis (EE) is an emerging worldwide disease that mimics gastroesophageal reflux disease...
  22. pmc Molecular pathways: pathogenesis and clinical implications of microbiome alteration in esophagitis and Barrett esophagus
    Liying Yang
    Department of Medicine and Pathology, New York University School of Medicine, New York, New York 10010, USA
    Clin Cancer Res 18:2138-44. 2012
    ..metaplasia or Barrett esophagus, which is a response to inflammation of the esophageal squamous mucosa, reflux esophagitis. Gastroesophageal reflux impairs the mucosal barrier in the distal esophagus, allowing chronic exposure of the ..
  23. ncbi Cow's milk protein-induced eosinophilic esophagitis in a child with gluten-sensitive enteropathy
    Amir F Kagalwalla
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Pediatr Gastroenterol Nutr 44:386-8. 2007
  24. pmc Association between body mass index and erosive esophagitis: a meta-analysis
    Nan Cai
    Department of Digestive Endoscopy and Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Nanjing 210011, Jiangsu Province, China
    World J Gastroenterol 18:2545-53. 2012
    To conduct a meta-analysis to estimate the determinants of the association between erosive esophagitis (EE) and body mass index (BMI).
  25. pmc Metabolic syndrome is associated with erosive esophagitis
    Jung Ho Park
    Department of Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, South Korea
    World J Gastroenterol 14:5442-7. 2008
    To clarify whether insulin resistance and metabolic syndrome are risk factors for erosive esophagitis.
  26. ncbi Systematic review of dose-volume parameters in the prediction of esophagitis in thoracic radiotherapy
    Jim Rose
    Department of Radiation Oncology, Kingston Regional Cancer Centre, ON, Canada
    Radiother Oncol 91:282-7. 2009
    With dose escalation and increasing use of concurrent chemoradiotherapy, radiation esophagitis (RE) remains a common treatment-limiting acute side effect in the treatment of thoracic malignancies...
  27. ncbi Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups
    Motohiko Kato
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Gastroenterol 46:1361-7. 2011
    ..Recently, visceral fat has been recognized as an endocrine organ that secretes various adipocytokines including adiponectin. The aim of this study was to elucidate the relation between adiponectin and erosive esophagitis.
  28. ncbi Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease
    David A Johnson
    Eastern Virginia Medical School, Division of Gastroenterology, Norfolk, 23505, USA
    Gastroenterology 126:660-4. 2004
    ..of reflux disease, it is unclear whether the severity of heartburn reliably indicates the severity of erosive esophagitis. We therefore assessed the relationship between age, severe heartburn symptoms, and severe erosive esophagitis.
  29. ncbi Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells
    Francesca Milano
    Laboratory of Experimental Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 132:2412-21. 2007
    ..In this study, the role of the BMP pathway in the metaplastic transformation of normal squamous cells into columnar cells was examined...
  30. ncbi Microscopic esophagitis and Barrett's esophagus: the histology report
    Roberto Fiocca
    Department of Anatomic Pathology, University of Genova and S Martino University Hospital, Genoa, Italy
    Dig Liver Dis 43:S319-30. 2011
    ..This paper details the histological criteria for diagnosing GERD-associated microscopic esophagitis, other forms of esophagitis with specific features and columnar metaplasia in the lower esophagus (Barrett's ..
  31. ncbi Treatment with high-dose proton pump inhibitors helps distinguish eosinophilic esophagitis from noneosinophilic esophagitis
    Wael N Sayej
    Digestive Diseases and Nutrition Center, Women and Children s Hospital of Buffalo, University at Buffalo, NY 14222, USA
    J Pediatr Gastroenterol Nutr 49:393-9. 2009
    Eosinophilic esophagitis (EE) is a clinical entity that is recognized increasingly in children. The treatment of EE has been debated since its identification as a clinical entity separate from reflux esophagitis...
  32. ncbi Relating acute esophagitis to radiotherapy dose using FDG-PET in concurrent chemo-radiotherapy for locally advanced non-small cell lung cancer
    Jasper Nijkamp
    Department of Radiation Oncoloyg, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Radiother Oncol 106:118-23. 2013
    To correlate radiotherapy (RT) dose to acute esophagitis (AE) by means of FDG-PET scans acquired after concurrent chemo-radiotherapy (cCRT) for locally advanced non-small-cell lung cancer (NSCLC).
  33. pmc Common variants at 5q22 associate with pediatric eosinophilic esophagitis
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Genet 42:289-91. 2010
    Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of eosinophils in the esophagus...
  34. ncbi Clinical and endoscopic features of eosinophilic esophagitis in adults
    John Croese
    Department of Gastroenterology, The Townsville Hospital, Townsville, Australia
    Gastrointest Endosc 58:516-22. 2003
    Eosinophilic esophagitis in adults is regarded as unusual, being diagnosed mostly in young men presenting with dysphagia. Mucosal furrows are a sentinel endoscopic feature...
  35. pmc Marked deposition of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitis
    Gail M Kephart
    Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 105:298-307. 2010
    Eosinophilic esophagitis (EoE) is characterized by infiltration of eosinophils into esophageal epithelium. Blood levels of an eosinophil granule protein, eosinophil-derived neurotoxin (EDN), have been proposed as a biomarker for EoE...
  36. ncbi Radiation-induced esophagitis on FDG PET imaging
    Peeyush Bhargava
    Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Nucl Med 28:849-50. 2003
  37. ncbi Celiac disease and eosinophilic esophagitis: a true association
    Connull Leslie
    Department of Anatomic Pathology, Princess Margaret Hospital for Children, Subiaco, Australia
    J Pediatr Gastroenterol Nutr 50:397-9. 2010
    Celiac disease (CD) and eosinophilic esophagitis (EE) are distinct disorders with specific clinico-pathological characteristics. Recent reports suggest an association between the 2...
  38. ncbi Biphasic effect of prostaglandin E2 in a rat model of esophagitis mediated by EP1 receptors: relation to pepsin secretion
    Masanori Yamato
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
    Digestion 72:109-18. 2005
    ..using subtype-selective EP agonists and antagonists as well as various COX inhibitors, in an acute rat esophagitis model. The animals were used after fasting for 18 h...
  39. pmc Involvement of mast cells in eosinophilic esophagitis
    J Pablo Abonia
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 126:140-9. 2010
    Eosinophilic esophagitis (EE) is an emerging disorder with poorly understood pathogenesis.
  40. ncbi Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review
    Evan S Dellon
    Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 102:2300-13. 2007
    Eosinophilic esophagitis (EoE) is an emerging clinicopathologic entity defined by abnormal esophageal eosinophilic infiltration. Our understanding of this disease is hampered by the lack of a uniform diagnostic standard...
  41. ncbi Gastroesophageal reflux disease--from reflux episodes to mucosal inflammation
    Arne Kandulski
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Leipziger Straβe 44, 39120 Magdeburg, Germany
    Nat Rev Gastroenterol Hepatol 9:15-22. 2012
    ..From bench to bedside, these novel molecular findings might provide new treatment options beyond current acid-suppressive therapy and the principle of inhibition of transient lower esophageal sphincter relaxation...
  42. ncbi Prevention of acute radiation-induced esophagitis with glutamine in non-small cell lung cancer patients treated with radiotherapy: evaluation of clinical and dosimetric parameters
    Erkan Topkan
    Baskent University Medical Faculty, Adana Medical and Research Center, Department of Radiation Oncology, Kisla Saglik Yerleskesi, 01120 Adana, Turkey
    Lung Cancer 63:393-9. 2009
    ..purpose of this study was to evaluate the efficacy of oral glutamine in the prevention of acute radiation-induced esophagitis (ARIE) and weight loss in lung carcinoma patients, and to determine the clinical/dosimetric predictors of ARIE.
  43. ncbi Gene mutations and polymorphisms of TP53 and FHIT in chronic esophagitis and esophageal carcinoma
    Aparecida Perpetuo Fedossi Silveira
    Department of Biology, UNESP, Sao Paulo State University, Sao Jose do Rio Preto, SP, Brazil
    Anticancer Res 31:1685-90. 2011
    The aim of this study was to investigate genetic changes of the TP53 (tumor protein p53) and FHIT (fragile histidine triad) genes in precursor lesion such as chronic esophagitis (CE) and in esophageal squamous cell carcinoma (ESCC).
  44. ncbi Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groups
    Robert C Kapel
    Division of Gastroenterology, Danbury Hospital, Danbury, Connecticut, USA
    Gastroenterology 134:1316-21. 2008
    Most reports on eosinophilic esophagitis (EE) are limited to small series from single institutions. This study describes features of EE in a broader population.
  45. ncbi The natural history of dysplasia and cancer in esophagitis and Barrett esophagus
    Stuart Jon Spechler
    Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    J Clin Gastroenterol 36:S2-5; discussion S26-8. 2003
    ..Dysplasia in the metaplastic epithelium clearly is a worrisome finding, but the progression from dysplasia to cancer may take years and may not be inevitable...
  46. ncbi Dosimetric correlates for acute esophagitis in patients treated with radiotherapy for lung carcinoma
    Jeffrey Bradley
    Department of Radiation Oncology, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 58:1106-13. 2004
    Acute esophagitis is a common complication of radiotherapy (RT) for non-small-cell carcinoma of the lung...
  47. ncbi Combination of longitudinal and circumferential three-dimensional esophageal dose distribution predicts acute esophagitis in hypofractionated reirradiation of patients with non-small-cell lung cancer treated in stereotactic body frame
    Igor M Poltinnikov
    Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 62:652-8. 2005
    To evaluate dosimetric predictors of acute esophagitis (AE) and clinical outcome of patients with non-small-cell lung cancer (NSCLC) receiving reirradiation.
  48. ncbi Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice
    Anil Mishra
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, OH 45229, USA
    J Leukoc Biol 81:916-24. 2007
    We have previously developed a murine model of allergen-induced eosinophilic esophagitis (EE), characterized by intraepithelial eosinophils, extracellular granule deposition, and epithelial cell hyperplasia, features that mimic the ..
  49. ncbi Detection of mucosal and cutaneous human papillomaviruses in oesophagitis, squamous cell carcinoma and adenocarcinoma of the oesophagus
    Maria Lina Tornesello
    Molecular Biology and Viral Oncology Unit and AIDS Reference Centre, National Cancer Institute Fond Pascale, Naples, Italy
    J Clin Virol 45:28-33. 2009
    ..Still controversial is the association of HPV infection with oesophageal neoplasia...
  50. ncbi Treatment-related pneumonitis and acute esophagitis in non-small-cell lung cancer patients treated with chemotherapy and helical tomotherapy
    Chang Hoon Song
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 78:651-8. 2010
    ..To assess clinical outcomes and complications in patients with non-small-cell lung cancer (NSCLC) treated with helical tomotherapy (HT) with or without chemotherapy...
  51. ncbi An update on the immunopathogenesis of eosinophilic esophagitis
    Alfredo J Lucendo
    Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, S N, 13700 Tomelloso, Spain
    Expert Rev Gastroenterol Hepatol 4:141-8. 2010
    Eosinophilic esophagitis (EoE) is a chronic clinicopathological entity characterized by large numbers of intraepithelial eosinophils infiltrating the esophageal mucosa, which is not caused by gastroesophageal reflux...
  52. ncbi Prevention of radiochemotherapy-induced esophagitis with glutamine: results of a pilot study
    Manuel Algara
    Department of Radiation Oncology, Hospital de l Esperança, Institut Municipal d Assistència Sanitària IMAS, Barcelona, Spain
    Int J Radiat Oncol Biol Phys 69:342-9. 2007
    To assess the usefulness of oral glutamine to prevent radiochemotherapy-induced esophagitis in patients with lung cancer, and to determine the dosimetric parameter predictive of esophagitis.
  53. ncbi Pollen and eosinophilic esophagitis
    Matthew I Fogg
    J Allergy Clin Immunol 112:796-7. 2003
  54. ncbi The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea
    N Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Aliment Pharmacol Ther 27:173-85. 2008
    ..Prospective nationwide multicentre studies that have evaluated endoscopic findings and reflux symptoms using a well-designed questionnaire are very rare...
  55. ncbi Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests
    Jonathan M Spergel
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Pennsylvania 19104 4399, USA
    Ann Allergy Asthma Immunol 95:336-43. 2005
    Eosinophilic esophagitis (EE) is a recently described disorder identified in patients with symptoms suggestive of gastroesophageal reflux disease (GERD) but unresponsive to conventional reflux therapies...
  56. ncbi Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis
    Amir F Kagalwalla
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 4:1097-102. 2006
    In children, eosinophilic esophagitis (EE) is predominantly, but not exclusively, a food-hypersensitivity disorder...
  57. ncbi Eosinophilic esophagitis: asthma of the esophagus?
    Amindra S Arora
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 2:523-30. 2004
    Eosinophilic esophagitis (EE) is rapidly emerging as a distinct disease entity in both pediatric and adult gastroenterology. The typical clinical presentation includes solid food dysphagia in young men who have an atopic predisposition...
  58. ncbi Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in children
    Seema S Aceves
    Division of Allergy and Immunology, Children s Hospital, San Diego, La Jolla, California, USA
    Am J Gastroenterol 102:2271-9; quiz 2280. 2007
    Eosinophilic esophagitis (EE) is a disorder characterized typically by pan-esophageal eosinophilia. We evaluate a palatable, long-acting topical corticosteroid preparation for the treatment of EE.
  59. pmc A novel histologic scoring system to evaluate mucosal biopsies from patients with eosinophilic esophagitis
    Cheryl Protheroe
    Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Clin Gastroenterol Hepatol 7:749-755.e11. 2009
    Eosinophilic esophagitis (EoE) is characterized by medically/surgically-resistant gastroesophageal reflux symptoms and dense squamous eosinophilia...
  60. ncbi The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis
    Jonathan M Spergel
    Allergy Section, Division of Immunologic and Infectious Disease, The Children s Hospital of Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 109:363-8. 2002
    Eosinophilic esophagitis is a disease entity in which patients have (1) elevated eosinophils on esophageal biopsy and (2) symptoms of gastroesophageal reflux...
  61. ncbi Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial
    Ranjan Dohil
    Departments of Pediatrics and Pathology, University of California, San Diego, La Jolla, California and Rady Children s Hospital San Diego, San Diego, California 92103 8450, USA
    Gastroenterology 139:418-29. 2010
    Eosinophilic esophagitis (EoE) is caused by immunologic reactions to ingested/inhaled allergens. The diagnosis is considered if >or=15 eosinophils per high-powered field (eos/hpf) are detected in mucosal biopsies...
  62. ncbi Ethnic differences in the prevalence of endoscopic esophagitis and Barrett's esophagus: the long and short of it all
    Shanmugarajah Rajendra
    Department of Medicine, Perak College of Medicine, Ipoh, Malaysia
    Dig Dis Sci 49:237-42. 2004
    ..The prevalence of erosive esophagitis and Barrett's esophagus in a multiethnic Malaysian population was studied, as well as the relationship of ..
  63. ncbi Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features
    Jon W Potter
    Division of Gastroenterology and Hepatology, Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Gastrointest Endosc 59:355-61. 2004
    Eosinophilic esophagitis is an inflammatory condition in which there is dense eosinophilic infiltration of the surface lining of the esophagus. Reports of eosinophilic esophagitis pertain almost exclusively to pediatric populations...
  64. ncbi A randomized double-blind study of caspofungin versus amphotericin for the treatment of candidal esophagitis
    A Villanueva
    Universidad de Antioquia, Medellin, Colombia
    Clin Infect Dis 33:1529-35. 2001
    ..of caspofungin relative to amphotericin B in adults with endoscopically documented symptomatic Candida esophagitis. By use of a modified intent-to-treat analysis, endoscopically verified clinical success was achieved in 74% (..
  65. pmc Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 184:4033-41. 2010
    We have previously proposed that the pathogenesis of eosinophilic esophagitis (EE) is mediated by an IL-13-driven epithelial cell response associated with marked gene dysregulation including eotaxin-3 overproduction...
  66. ncbi Proinflammatory cytokines alter/reduce esophageal circular muscle contraction in experimental cat esophagitis
    Weibiao Cao
    Department of Medicine, Rhode Island Hospital and Brown University, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1131-9. 2004
    ..After induction of experimental esophagitis by repeated acid perfusion, the responses to swallowing and to EFS were significantly reduced but contraction ..
  67. pmc Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis
    Steve Hernandez
    Department of Medicine, Division Infectious Diseases 7881, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Antimicrob Agents Chemother 48:1382-3. 2004
    A patient with azole-refractory thrush-esophagitis responded initially to caspofungin, but the treatment eventually failed...
  68. ncbi Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications
    Howard Hampel
    Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann Intern Med 143:199-211. 2005
    The association of body mass index and gastroesophageal reflux disease (GERD), including its complications (esophagitis, Barrett esophagus, and esophageal adenocarcinoma), is unclear.
  69. ncbi Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Gastroenterology 125:1419-27. 2003
    ..that simultaneous delivery of allergen to the lung and gastrointestinal tract induces experimental eosinophilic esophagitis (EE)...
  70. ncbi Predictors of radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with three-dimensional conformal radiotherapy
    Anurag K Singh
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 55:337-41. 2003
    ....
  71. ncbi Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents
    Jonathan E Markowitz
    Divisions of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 98:777-82. 2003
    Eosinophilic esophagitis (EoE), a disorder characterized by eosinophilic infiltration of the esophageal mucosa, has been defined in large part through published case reports and series leading to ambiguity in both diagnostic and ..
  72. ncbi Eosinophilic esophagitis: a 10-year experience in 381 children
    Chris A Liacouras
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Gastroenterol Hepatol 3:1198-206. 2005
    Eosinophilic esophagitis (EoE) is a disorder characterized by a severe, isolated eosinophilic infiltration of the esophagus unresponsive to aggressive acid blockade but responsive to the removal of dietary antigens...
  73. ncbi Eosinophilic esophagitis: it's not just kid's stuff
    Victor L Fox
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastrointest Endosc 56:260-70. 2002
  74. ncbi Eosinophilic esophagitis in children with celiac disease
    Chee Y Ooi
    Department of Gastroenterology, Sydney Children s Hospital, Randwick, NSW, Australia
    J Gastroenterol Hepatol 23:1144-8. 2008
    Eosinophilic esophagitis and celiac disease are distinct gastrointestinal disorders. The present study in children highlights the possible coexistence of these two conditions...
  75. ncbi Comparison of inter- and intraobserver consistency for grading of esophagitis by expert and trainee endoscopists
    John E Pandolfino
    Northwestern University Medical School, Chicago, Illinois 60611, USA
    Gastrointest Endosc 56:639-43. 2002
    This study evaluated intra- and interobserver variability in the endoscopic scoring of esophagitis by using two grading schemes, the Los Angeles and Hetzel-Dent scales.
  76. pmc The association between obesity and GERD: a review of the epidemiological evidence
    Hashem El-Serag
    The Sections of Gastroenterology and Health Services Research, The Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
    Dig Dis Sci 53:2307-12. 2008
    ..GERD and some of its complications, including a generally consistent association with GERD symptoms, erosive esophagitis, and esophageal adenocarcinoma...
  77. ncbi Effect of Helicobacter pylori eradication on development of erosive esophagitis and gastroesophageal reflux disease symptoms: a post hoc analysis of eight double blind prospective studies
    Loren Laine
    Department of Medicine, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Am J Gastroenterol 97:2992-7. 2002
    The aim of this study was to assess the development of erosive esophagitis, the development of gastroesophageal reflux disease (GERD) symptoms in patients without prior symptomatic or endoscopic GERD, and the worsening of GERD symptoms ..
  78. ncbi High-resolution EUS in children with eosinophilic "allergic" esophagitis
    Victor L Fox
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastrointest Endosc 57:30-6. 2003
    The pathophysiology of dysphagia associated with eosinophilic esophagitis is unknown...
  79. ncbi Eosinophilic esophagitis
    Jonathan E Markowitz
    Division of Gastroenterology and Nutrition, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Gastroenterol Clin North Am 32:949-66. 2003
    ..These reviews coupled with the past reports and increasing incidence of EoE provide a sound background for further research on the etiology, epidemiology and treatment of EoE...
  80. ncbi Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases
    Dagmar Simon
    J Allergy Clin Immunol 115:1090-2. 2005
  81. ncbi p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease
    Marilanda Ferreira Bellini
    Department of Biology, UNESP, Sao Paulo State University, Campus São José do Rio Preto, SP, Brazil
    Anticancer Res 28:3793-9. 2008
    Models have suggested esophageal carcinogenesis can result from the alteration of sequences, leading to esophagitis, atrophy, dysplasia, carcinoma in situ and invasive carcinoma...
  82. ncbi Is there a seasonal variation in the incidence or intensity of allergic eosinophilic esophagitis in newly diagnosed children?
    Flint Y Wang
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Gastroenterol 41:451-3. 2007
    Allergic eosinophilic esophagitis (AEE) is thought to be an allergic reaction that is characterized by inflammation caused by predominant accumulation of eosinophils in esophageal mucosa (> or =15 eosinophils per high power field).
  83. ncbi Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis
    Alex Straumann
    Department of Gastroenterology, University Hospital Basel, Basel, Switzerland
    Gastroenterology 139:1526-37, 1537.e1. 2010
    Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by dense tissue eosinophilia; it is refractory to proton pump inhibitor therapy...
  84. ncbi The role of allergy evaluation in adults with eosinophilic esophagitis
    Joshua D Penfield
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Gastroenterol 44:22-7. 2010
    Allergy evaluation and skin prick testing for foods are recommended in all patients with eosinophilic esophagitis. However, the yield of allergy evaluation in adult eosinophilic esophagitis is not known.
  85. ncbi Patient and caregiver perspective on pediatric eosinophilic esophagitis and newly developed symptom questionnaires*
    Emuella M Flood
    Oxford Outcomes Inc, Bethesda, MD 20814, USA
    Curr Med Res Opin 24:3369-81. 2008
    Eosinophilic esophagitis (EE), a rare chronic inflammatory condition of the esophagus, is predominantly observed in children and is primarily manifested with feeding difficulties...
  86. ncbi Esophageal subepithelial fibrosis in children with eosinophilic esophagitis
    Mirna Chehade
    Department of Pediatric Gastroenterology and Nutrition, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Pediatr Gastroenterol Nutr 45:319-28. 2007
    Esophageal subepithelial fibrosis has been reported in adults with eosinophilic esophagitis (EE)...
  87. ncbi Activated mucosal mast cells differentiate eosinophilic (allergic) esophagitis from gastroesophageal reflux disease
    Richard Kirsch
    Division of Pathology, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 44:20-6. 2007
    To evaluate the utility of activated mucosal mast cells (MC) in the differential diagnosis of eosinophilic esophagitis (EE) and gastroesophageal reflux disease (GERD).
  88. pmc Eosinophilic esophagitis
    Anand R Gupte
    Department of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida 32610, USA
    World J Gastroenterol 15:17-24. 2009
    Eosinophilic esophagitis is increasingly recognized in adults. The diagnosis is based on the presence of both typical symptoms and pathologic findings on esophageal biopsy...
  89. ncbi Predictive values for skin prick test and atopy patch test for eosinophilic esophagitis
    Jonathan M Spergel
    J Allergy Clin Immunol 119:509-11. 2007
  90. pmc Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis
    Joseph D Sherrill
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 126:160-5.e3. 2010
    The genetic cause of eosinophilic esophagitis (EE) has been largely unexplored until a recent genome-wide association study identified a disease susceptibility locus on 5q22, a region that harbors the thymic stromal lymphopoietin (TSLP) ..
  91. ncbi Pediatric patients with eosinophilic esophagitis: an 8-year follow-up
    Amal H Assa'ad
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 119:731-8. 2007
    Eosinophilic esophagitis (EE) is a gastrointestinal disorder that is increasingly diagnosed in pediatric patients.
  92. ncbi Primary eosinophilic esophagitis
    V Munitiz
    Department of Surgery, Virgen de la Arrixaca University Hospital Murcia, Spain
    Dis Esophagus 16:165-8. 2003
    Eosinophilic esophagitis is an uncommon pathology that generally affects children with a history of allergies and intrinsic asthma...
  93. ncbi The Los Angeles and Savary-Miller systems for grading esophagitis: utilization and correlation with histology
    R M Genta
    Department of Gastrointestinal Pathology, Caris Research Institute, Irving, Texas, USA
    Dis Esophagus 24:10-7. 2011
    ..the proportion of patients who have esophageal biopsy specimens taken for an endoscopic diagnosis of reflux esophagitis in which an endoscopic grade of esophagitis (Los Angeles [LA] or Savary-Miller [SM]) is communicated to the ..
  94. ncbi Atypical croup: association with airway lesions, atopy, and esophagitis
    Timothy Cooper
    Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Otolaryngol Head Neck Surg 147:209-14. 2012
    ..To report on airway endoscopic findings and gastrointestinal and atopic conditions in a large consecutive series of atypical croup...
  95. ncbi Noninvasive markers of eosinophilic esophagitis
    Sandeep K Gupta
    Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, ROC 4210, Indianapolis, IN 46202, USA
    Gastrointest Endosc Clin N Am 18:157-67; xi. 2008
    There has been an increasing awareness and recognition of eosinophilic esophagitis (EE), a chronic condition with periods of exacerbation and remission, over the last decade...
  96. ncbi The prevalence of Barrett's esophagus and erosive esophagitis in patients undergoing upper endoscopy for dyspepsia in a VA population
    Michael J Connor
    Division of Gastroenterology, Department of Preventive Medicine and Public Health and Kansas Cancer Institute, University of Kansas and Veterans Affairs Medical Center, Kansas City, Missouri, USA
    Dig Dis Sci 49:920-4. 2004
    The purpose of this study was to establish the prevalence of Barrett's esophagus and erosive esophagitis in a group of patients undergoing upper endoscopy for dyspepsia...
  97. ncbi Recurring Candida albicans esophagitis in a HIV-infected patient undergoing long-Term antiretroviral therapy, and with absent-negligible immunodeficiency
    Roberto Manfredi
    Division of Infectious Diseases, Department of Clinical and Experimental Medicine, S Orsola Malpighi Hospital, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Braz J Infect Dis 11:605-9. 2007
    A patient with HIV infection developed the first episode of AIDS-defining opportunism (severe Candida albicans esophagitis) with an underlying CD4+ lymphocyte count of 1,025 cells/microL...
  98. ncbi Erosive esophagitis after bariatric surgery: banded vertical gastrectomy versus banded Roux-en-Y gastric bypass
    Gustavo Peixoto Soares Miguel
    Federal University of Espírito Santo UFES, Vitoria, ES, Brazil
    Obes Surg 21:167-72. 2011
    ..The aim of this study was to compare the evolution of erosive esophagitis (EE) in patients who underwent Silastic® ring gastric bypass (SRGB) and Silastic® ring sleeve gastrectomy (..
  99. pmc Heartburn severity does not predict disease severity in patients with erosive esophagitis
    M Brian Fennerty
    Division of Gastroenterology, Oregon Health and Science University, Portland, Oregon, USA
    MedGenMed 8:6. 2006
    For patients with gastroesophageal reflux disease (GERD), it is often assumed by treating physicians that the severity of heartburn correlates with the severity of erosive esophagitis (EE).
  100. ncbi Simultaneous herpes simplex virus esophagitis and lupus enteritis in a patient with systemic lupus erythematosus
    Hideki Wakui
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Mod Rheumatol 20:98-101. 2010
    ..Herpes simplex virus (HSV) esophagitis and lupus enteritis were diagnosed on the basis of the results of endoscopic and histological examinations and ..
  101. ncbi Drug-induced esophagitis
    G N Zografos
    Department of Sugery, Athens General Hospital, Athens, Greece
    Dis Esophagus 22:633-7. 2009
    Drug-induced esophagitis is being recognized increasingly in the past few years. Since 1970 more than 650 cases have been reported worldwide caused by 30 or more medications...

Research Grants62

  1. The Prevalence of Barrett's Esophagus in Patients with *
    Blair Jobe; Fiscal Year: 2004
    ..Substantial published data support a causal relation between complicated GERD (esophagitis and Barrett's metaplasia) and extraesophageal reflux symptoms...
  2. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2013
    ..Eosinophils and mast cells are implicated in other chronic diseases including eosinophilic esophagitis. Systemic Mastocytosis, a malignant disease, presents with varying prognoses depending on the extent of ..
  3. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2012
    ..Eosinophils and mast cells are implicated in other chronic diseases including eosinophilic esophagitis. Systemic Mastocytosis, a malignant disease, presents with varying prognoses depending on the extent of ..
  4. Mouse models for esophageal Cox-2 oxidative stress and DNA damage
    John P Lynch; Fiscal Year: 2013
    ..We therefore hypothesize that Cox-2 expression in the murine esophagus results in a chronic esophagitis that models GERD esophagitis by provoking oxidative stress, DNA damage, and the development of metaplasia and ..
  5. Modeling oxidative stress and DNA damage using GI organotypic culture systems
    John P Lynch; Fiscal Year: 2013
    ..pursuing the following Specific Aims: 1) Adapt the esophageal organotypic culture system to better model GERD esophagitis and progression of stem cells to metaplasia and dysplasia...
  6. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
    ..common for patients to take these potent acid suppressants on a long-term and continuous basis for erosive esophagitis, Barrett's esophagus and protection against nonsteroidal anti-inflammatory drug-related gastropathy...
  7. Targeting the DNA damage response pathway for the treatment of HSV esophagitis
    Oleg Alekseev; Fiscal Year: 2013
    ..The estimates of the incidence of herpes esophagitis vary widely, with some studies reporting as much as 15% of transplant recipients testing positive...
  8. Patient research in eosinophilic gastrointestinal diseases
    Glenn T Furuta; Fiscal Year: 2013
    ..an increasing incidence estimated at 4 in 10,000, diagnostic criteria for one type of EGID, eosinophilic esophagitis (EoE), has only recently been defined...
  9. Role of Acid in the Development of Barrett's Esophagus
    Stuart Jon Spechler; Fiscal Year: 2013
    ..In a rat model of reflux esophagitis in which an esophago-duodenostomy is created to induce reflux, we recently studied the early histological ..
  10. Investigation of the Role of TGF Beta in TH2-Mediated Disease
    PAMELA ANN GUERRERIO; Fiscal Year: 2013
    ..LDS appears to be the first Mendelian disorder associated with the development of food allergy and eosinophilic esophagitis, and offers an unparalleled opportunity to study the role of TGF-[unreadable] in the human immune system...
  11. Mechanisms of tissue damage leading to chronic allergic eosinophilic esophagitis
    Seema S Aceves; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EE) is a chronic allergic disease of increasing prevalence diagnosed as an acid- independent esophageal eosinophilia of >15 per high power field...
  12. Toll-like Receptor Signaling in the Esophageal Epithelium
    Mei Lun Wang; Fiscal Year: 2013
    ..In addition to its significant socioeconomic burden, longstanding GERD esophagitis is a risk factor for Barrett's esophagus, a premalignant condition associated with the development of ..
  13. Normal Tissue Complication Modeling for Radiotherapy
    Joseph Deasy; Fiscal Year: 2009
    ..Under SA #2, Improvements in acute esophagitis NTCP models, we will: (a) accrue more patients (from 166 to an estimated 450 in 4 years), (b) incorporate new ..
  14. The Role of Periostin and Th2 Cytokines in Eosinophilic Esophagitis Fibrogenesis
    Edaire Cheng; Fiscal Year: 2013
    ..and funded physician-scientist with a research focus on fibrogenesis and tissue remodeling in eosinophilic esophagitis (EoE)...
  15. Risk Factors and Biomarkers for Diagnosis &Treatment of Eosinophilic Esophagitis
    EVAN SAMUEL DELLON; Fiscal Year: 2013
    ..research methodology, and a proven commitment to the study of esophageal diseases, and eosinophilic esophagitis (EoE) in particular...
  16. The role of iNKTs in eosinophilic esophagitis.
    Antonella Cianferoni; Fiscal Year: 2013
    ..Pediatric FA affects 6-8% of children, in whom it is the major risk factor for anaphylaxis and eosinophilic esophagitis (EoE)...
  17. Role of IL-6/STAT3 Signaling in the Neoplastic Progression of Barrett's Esophagus
    Rhonda F Souza; Fiscal Year: 2013
    ..cancer that can be established through two pathways: 1) an extrinsic pathway in which disorders such as reflux esophagitis cause tissue inflammation that contributes to carcinogenesis, and 2) an intrinsic pathway in which the ..
  18. REGULATION OF GASTROINTESTINAL EOSINOPHILS
    Marc E Rothenberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eosinophilic gastrointestinal disorders (EGID) (i.e. eosinophilic esophagitis [EE]) are being increasingly recognized over the last decade yet they have been greatly understudied compared with other ..
  19. THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASE
    Peter James Kahrilas; Fiscal Year: 2013
    ..This can cause esophagitis or a host of nonspecific symptoms...
  20. Transnasal Probe for Diagnosing Eosinophilic Esophagitis
    Guillermo J Tearney; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EoE) is an inflammatory condition of the esophagus, thought to be caused by food allergy, and characterized by the presence of eosinophils within the esophageal mucosa...
  21. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2012
    ..EA is the end result of a sequence of GERD-related diseases, preceded by reflux esophagitis (RE) and Barrett's esophagus (BE)...
  22. Phase 2 Study of Esophageal String Test in Diagnosing Eosinophilic Esophagitis
    Glenn T Furuta; Fiscal Year: 2013
    PROJECT SUMMARY Eosinophilic esophagitis (EoE) is an increasingly recognized rare disease of children and adults characterized by symptoms including nausea, vomiting, abdominal pain, dysphagia and food impaction that occur in ..
  23. The Influence of Hospital Variability on the Management of Cancer-Associated Comp
    Jason Wright; Fiscal Year: 2013
    ..hospitalized patients admitted with a primary diagnosis of: febrile neutropenia, hypercalcemia of malignancy, esophagitis, and acute cancer-associated pain...
  24. ESOPHAGEAL CYTOPROTECTION--AGENTS AND MECHANISMS
    Roy Orlando; Fiscal Year: 2009
    The long term goal of this proposal is to understand the pathogenesis of the human disease, reflux esophagitis (RE), and this approached mechanistically and from the relatively uncommon vantage point of the target tissue, the esophageal ..
  25. A multi-center clinical trial of 1760 mcg of daily swallowed fluticasone vs. plac
    Marc E Rothenberg; Fiscal Year: 2010
    Eosinophilic esophagitis (EE) is an emerging vyorldwide disease that mimics gastroesophageal reflux disease (GERD) and can lead to esophageal narrowing and stricture (1-4)...
  26. Cytokine regulation of human basophil responses
    Elia D Tait Wojno; Fiscal Year: 2013
    ..express the TSLP receptor (TSLPR), and that basophils isolated from patients suffering from eosinophilic esophagitis (EoE) are more likely to express the IL-33R...
  27. Epithelial Genes In Allergic Inflammation
    Gurjit K Khurana Hershey; Fiscal Year: 2013
    ..e. lung (asthma), skin (atopic dermatitis), or gut (food allergy or eosinophilic esophagitis)...
  28. Comparative Effectiveness of endoscopic assessment of GER and BE
    Prasad G Iyer; Fiscal Year: 2012
    ..Subaim 2b: To compare the rates of detection of esophageal injury (esophagitis, strictures and BE) between cohorts stratified by presence/absence of GER symptoms using a validated symptom ..
  29. ESOPHAGEAL MOTOR FUNCTION IN HEALTH AND DISEASE
    REZA NONE SHAKER; Fiscal Year: 2013
    ..We have focused these studies on two animal models;repeated acid exposure and chronic erosive esophagitis. These resemble non-erosive and erosive reflux in humans...
  30. Immunobiology of Food Allergy and Its Treatment
    Hugh Sampson; Fiscal Year: 2013
    ..The prevalence of peanut allergy in children has doubled since the mid-1990's, and eosinophilic esophagitis (EE), largely food-related in children, has also markedly increased in prevalence...
  31. IGF::OT::IGF R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH) A NOVEL AGENT THAT REDUCE
    Jeffery Fairman; Fiscal Year: 2013
    ..transgene expressing human superoxide dismutase 2 (SOD2) (JVRSOD) protects the esophagus from radiation-induced esophagitis (a form of mucositis) in mice...
  32. Novel minimally invasive assessment of gastrointestinal inflammation in food alle
    Glenn Furuta; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EE) is an increasingly recognized gastrointestinal disease that accounts for ~50% of pediatric and adult cases of dysphagia and food impaction...
  33. Mechanistic Analysis of Eosinophilic Esophagitis.
    Anil Mishra; Fiscal Year: 2013
    ..Our studies are timely given the recent attention that EE is receiving in the medical community. ..
  34. Ulcerative Colitis - Regulation of the IL-13 Receptor System
    Peter Mannon; Fiscal Year: 2013
    ..The results will be applicable to other mucosal inflammatory diseases like allergic asthma and eosinophilic esophagitis where IL-13 also drives disease and new therapies targeting IL-13 are needed.
  35. Regulation of Allergic Inflammation by Histamine
    Paul J Bryce; Fiscal Year: 2013
    ..Specific Aim 3 will examine histamine-associated gene patterns in the pathogenesis of eosinophilic esophagitis and build on our existing work demonstrating the mast cells and histamine are important in this disease.
  36. Maturational Characterization of Human Esophageal Fibroblasts in EoE
    AMANDA BROOKE MUIR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EoE) is an allergic disease characterized by esophageal infiltration of eosinophils, diagnosed from childhood through adulthood...
  37. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2009
    ..EA is the end result of a sequence of GERD-related diseases, preceded by reflux esophagitis (RE) and Barrett's esophagus (BE)...
  38. Patient Oriented Research in Pediatric Motility and Related Disorders
    Samuel Nurko; Fiscal Year: 2013
    ..This project is focused on finding new biomarkers for the evaluation of children with eosinophilic esophagitis. Trainees interested in pediatric motility and related disorders will be encouraged to become directly involved ..
  39. Urinary Metabolites in Eosinophilic Esophagitis
    Glenn R Gourley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EoE), a rapidly emerging allergic disease affecting all ages, presents with esophageal food impaction, dysphagia, growth problems, and esophageal stricturing...
  40. THE DIAPHRAGM--AN EXTERNAL LOWER ESOPHAGEAL SPHINCTER
    RAVINDER MITTAL; Fiscal Year: 1993
    ..in relation to its sphincteric function, 4) sphincteric function of the diaphragm in patients with reflux esophagitis, and 5) the primary abnormality in patients with achalasia of the esophagus is it the diaphragm or the LES? We ..
  41. Influence of acid reflux on stromal epithelial interaction in Barrett?s esophagus
    GANAPATHY PRASAD; Fiscal Year: 2009
    ..Patients will then be divided into Group A (GER): with acid reflux (characterized by either presence of esophagitis (as determined by the Los Angeles classification) 10 on endoscopy, and/or a positive pH study defined by ..
  42. NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2007
    ..of GERD patients develop Barrett's esophagus (BE) where esophageal squamous epithelium damaged by reflux esophagitis is replaced by a metaplastic, intestinal- type epithelium...
  43. Genetic Linkage Analysis of Barrett's Esophagus
    Yvonne Romero; Fiscal Year: 2005
    ..of Barrett's probands without frequent gastroesophageal reflux symptoms are 4-fold more likely to have erosive esophagitis compared to non-symptomatic controls; 2) Twin studies showing the heritable attributable risk of GERD symptoms ..
  44. Role of H. Pylori Infection in Esophageal Adenocarcinoma
    Kam Meng Tchou Wong; Fiscal Year: 2003
    ..Colonization with cagA+ strains has been shown to be inversely associated with reflux esophagitis and Barrett's esophagus...
  45. PHARYNGEAL RECEPTORS AND REFLUX DISEASE
    RAVINDER MITTAL; Fiscal Year: 2001
    ..Effects of atropine on the frequency of TLESR and GER in patients with reflux esophagitis.
  46. ESOPHAGO-LARYNGEAL ADDUCTOR REFLEX
    Nancy Bauman; Fiscal Year: 2000
    ..5. To determine if esophageal acidification induces the ELAR in immature canines with acute esophagitis. These specific aims will be explored in immature canines by applying 0...
  47. Molecular epidemiology of Barretts esophagus and cancer
    David Whiteman; Fiscal Year: 2006
    ..we aim to quantify the risks associated with exposure to epidemiologic and genetic risk factors for reflux esophagitis (RE), BE and AC...
  48. NOVEL PROTEIN KINASE IN DIGESTIVE ENZYME SECRETION
    Laura Tang; Fiscal Year: 1999
    ..process of the gastrointestinal tract and is considered to contribute to pathological processes such as reflux esophagitis, peptic ulcer disease and pancreatitis...
  49. GENETIC EPIDEMIOLOGY OF BARRETT'S ESOPHAGUS
    Yvonne Romero; Fiscal Year: 2005
    ..symptoms in families of probands with Barrett's esophagus and esophageal adenocarcinoma (but not solo reflux esophagitis), was published in Gastroenterology in 1997. In the Barrett's Esophagus Genomic Study, for which Dr...
  50. Genetics of Eosinophilic Esophagitis
    Ning Wang; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Eosinophilic esophagitis (EE) is an emerging worldwide disease characterized by the accumulation of eosinophils in the esophagus...
  51. ESOPHAGEAL CLEARANCE IN HEALTH & DISEASE
    James Helm; Fiscal Year: 1991
    ..clearance in health and disease with a special emphasis on its role as an important defense against reflux esophagitis. The aim of this grant will be achieved by pursuing three interrelated objectives: 1) Investigate the ..
  52. iNOS, COX-2, and Arginase in Murine Barrett's Esophagus
    Keith Wilson; Fiscal Year: 2003
    ..We will study macroscopic and histologic evidence of esophagitis, BE and BAA, gene expression, apoptosis and proliferation in A. wild-type (WT) vs. COX-2-/- mice, B. W'I- vs...
  53. TSG6 in IgE mediated Food Allergy
    Carine Blanchard; Fiscal Year: 2009
    ..time, we also discovered that TSG6 mRNA was upregulated in a human food allergy related disease, eosinophilic esophagitis (EE) (2)...
  54. CANDIDA DIMORPHISM--VIRULENCE & IMMUNOMODULATORY ACTION
    Thomas Rogers; Fiscal Year: 1992
    ..Patients with Acquired Immune Deficiency Syndrome (AIDS) frequently develop severe candidal esophagitis. Patients receiving chemotherapy are also at increased risk for invasive candidiasis...
  55. Pimecrolius on T cell Responses in Atopic March
    Jonathan Spergel; Fiscal Year: 2008
    ..In third aim of the trial, we explore the effects of pimecrolimus as a disease-modifying agent in the prevention of asthma. Asthma phenotype will be examined by spirometry per and post-beta-2-agonist and exhaled nitric oxide. ..
  56. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  57. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..