esophageal and gastric varices

Summary

Summary: Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).

Top Publications

  1. ncbi Prediction of esophageal varices in patients with cirrhosis
    Ravi Madhotra
    Liver Service, Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Clin Gastroenterol 34:81-5. 2002
  2. ncbi Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Yale University School of Medicine and VACT Healthcare System, New Haven, CT, USA
    Hepatology 46:922-38. 2007
  3. ncbi Early use of TIPS in patients with cirrhosis and variceal bleeding
    Juan Carlos Garcia-Pagan
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metaboliques, University of Barcelona, Barcelona, Spain
    N Engl J Med 362:2370-9. 2010
  4. ncbi Balloon-occluded retrograde transvenous obliteration of gastric varices with gastrorenal shunt: long-term follow-up in 78 patients
    Teruhisa Ninoi
    Department of Radiology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    AJR Am J Roentgenol 184:1340-6. 2005
  5. ncbi Balloon-occluded retrograde transvenous obliteration of gastric varices: outcomes and complications in 49 patients
    Sung Ki Cho
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon dong 50, Kangnam Ku, Seoul 135 710, Korea
    AJR Am J Roentgenol 189:W365-72. 2007
  6. ncbi Incidence and natural history of small esophageal varices in cirrhotic patients
    Manuela Merli
    II Gastroenterology Unit, Department of Clinical Medicine, University of Rome La Sapienza, Viale dell Universita 37, 00185 Rome, Italy
    J Hepatol 38:266-72. 2003
  7. ncbi Improved survival after variceal bleeding in patients with cirrhosis over the past two decades
    Nicolas Carbonell
    Hopital Saint Antoine, Service d Hepatogastroenterologie, AP HP, Universite Pierre et Marie Curie, Paris, France
    Hepatology 40:652-9. 2004
  8. ncbi Measurement of spleen stiffness by acoustic radiation force impulse imaging identifies cirrhotic patients with esophageal varices
    Yoshitaka Takuma
    Department of Gastroenterology, Kurashiki Central Hospital, Okayama, Japan
    Gastroenterology 144:92-101.e2. 2013
  9. ncbi A pathophysiologic, gastroenterologic, and radiologic approach to the management of gastric varices
    Barbara M Ryan
    Department of Gastroenterology, Manchester Royal Infirmary, UK
    Gastroenterology 126:1175-89. 2004
  10. ncbi Pathomorphology of esophageal and gastric varices
    Masahiro Arakawa
    Department of Pathology, Omuta City General Hospital, Omuta, Japan
    Semin Liver Dis 22:73-82. 2002

Detail Information

Publications272 found, 100 shown here

  1. ncbi Prediction of esophageal varices in patients with cirrhosis
    Ravi Madhotra
    Liver Service, Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Clin Gastroenterol 34:81-5. 2002
    ..To identify predictors of esophageal varices (EV) using available clinical, laboratory, and diagnostic imaging variables...
  2. ncbi Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Yale University School of Medicine and VACT Healthcare System, New Haven, CT, USA
    Hepatology 46:922-38. 2007
  3. ncbi Early use of TIPS in patients with cirrhosis and variceal bleeding
    Juan Carlos Garcia-Pagan
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metaboliques, University of Barcelona, Barcelona, Spain
    N Engl J Med 362:2370-9. 2010
    ..This study evaluated the earlier use of TIPS in such patients...
  4. ncbi Balloon-occluded retrograde transvenous obliteration of gastric varices with gastrorenal shunt: long-term follow-up in 78 patients
    Teruhisa Ninoi
    Department of Radiology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    AJR Am J Roentgenol 184:1340-6. 2005
    ..Our aim was to evaluate the long-term clinical results after balloon-occluded retrograde transvenous obliteration (B-RTO) for gastric varices with spontaneous gastrorenal shunt...
  5. ncbi Balloon-occluded retrograde transvenous obliteration of gastric varices: outcomes and complications in 49 patients
    Sung Ki Cho
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon dong 50, Kangnam Ku, Seoul 135 710, Korea
    AJR Am J Roentgenol 189:W365-72. 2007
    ..Our aim was to evaluate the clinical outcomes, techniques, and complications of balloon-occluded retrograde transvenous obliteration for treating gastric varices with spontaneous gastrosystemic shunts...
  6. ncbi Incidence and natural history of small esophageal varices in cirrhotic patients
    Manuela Merli
    II Gastroenterology Unit, Department of Clinical Medicine, University of Rome La Sapienza, Viale dell Universita 37, 00185 Rome, Italy
    J Hepatol 38:266-72. 2003
    ..The incidence and natural history of small esophageal varices (EV) in cirrhotics may influence the frequency of endoscopies and the decision to start a pharmacological treatment in these patients...
  7. ncbi Improved survival after variceal bleeding in patients with cirrhosis over the past two decades
    Nicolas Carbonell
    Hopital Saint Antoine, Service d Hepatogastroenterologie, AP HP, Universite Pierre et Marie Curie, Paris, France
    Hepatology 40:652-9. 2004
    ....
  8. ncbi Measurement of spleen stiffness by acoustic radiation force impulse imaging identifies cirrhotic patients with esophageal varices
    Yoshitaka Takuma
    Department of Gastroenterology, Kurashiki Central Hospital, Okayama, Japan
    Gastroenterology 144:92-101.e2. 2013
    ..We evaluated whether spleen stiffness (SS), measured by acoustic radiation force impulse imaging, can identify patients who have esophageal varices (EVs); those without EVs would not require endoscopic examination...
  9. ncbi A pathophysiologic, gastroenterologic, and radiologic approach to the management of gastric varices
    Barbara M Ryan
    Department of Gastroenterology, Manchester Royal Infirmary, UK
    Gastroenterology 126:1175-89. 2004
    ..The role of some newer interventional radiologic techniques requires further appraisal. This review describes the pathophysiology, diagnosis, natural history, endoscopic, and interventional radiologic treatment options for GV...
  10. ncbi Pathomorphology of esophageal and gastric varices
    Masahiro Arakawa
    Department of Pathology, Omuta City General Hospital, Omuta, Japan
    Semin Liver Dis 22:73-82. 2002
    ..Most ruptures occur in this critical area. The basic differences between esophageal and gastric varices are the layers in which the varicose veins form: the lamina propria mucosae and submucosa in the ..
  11. ncbi Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis
    Cristina Ripoll
    Veterans Affairs CT Healthcare System, Yale University School of Medicine, West Haven, Connecticut 06516, USA
    Gastroenterology 133:481-8. 2007
    ....
  12. pmc Long-term result of endoscopic Histoacryl (N-butyl-2-cyanoacrylate) injection for treatment of gastric varices
    Eun Jung Kang
    Institute for Digestive Research, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul Hospital, Seoul 140 743, South Korea
    World J Gastroenterol 17:1494-500. 2011
    ..To evaluate the long-term efficacy and safety of endoscopic obliteration with Histoacryl(®) for treatment of gastric variceal bleeding and prophylaxis...
  13. ncbi Measurement of spleen stiffness to evaluate portal hypertension and the presence of esophageal varices in patients with HCV-related cirrhosis
    Antonio Colecchia
    Department of Clinical Medicine, University of Bologna, Bologna, Italy
    Gastroenterology 143:646-54. 2012
    ..We compared the diagnostic performance of spleen stiffness (SS) measurement by transient elastography with that of liver stiffness (LS) and of other recently proposed noninvasive tests...
  14. ncbi Noninvasive assessment of portal hypertension in patients with cirrhosis
    Dominique Thabut
    Institut National de la Santé et de la Recherche Médicale Unité 773, Centre de recherche Biomedicale Bichat Beaujon, Paris, France
    Hepatology 53:683-94. 2011
    ..Although most of these noninvasive methods effectively identify severe portal hypertension, methods for diagnosing moderate portal hypertension need to be developed; this shows that further investigation is needed in this field...
  15. ncbi General rules for recording endoscopic findings of esophagogastric varices (2nd edition)
    Takashi Tajiri
    The Japan Society for Portal Hypertension, Tokyo, Japan
    Dig Endosc 22:1-9. 2010
    ..The revised rules are simpler and more straightforward than the former rules and include newly recognized findings of portal hypertensive gastropathy and a new classification for endoscopic ultrasonographic findings...
  16. ncbi Etiology of portal hypertension may influence gastrointestinal transit
    R Sadik
    Division of Gastroenterology, Institute of Internal Medicine, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    Scand J Gastroenterol 38:1039-44. 2003
    ..We have studied gastric emptying. small-bowel transit and colonic transit in patients with portal hypertension. The association between small-bowel bacterial overgrowth and gastrointestinal transit was assessed...
  17. pmc Endothelial dysfunction in the regulation of cirrhosis and portal hypertension
    Yasuko Iwakiri
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Liver Int 32:199-213. 2012
    ..The article ends by discussing the future directions of the study for endothelial dysfunction...
  18. ncbi A randomized trial of endoscopic treatment of acute gastric variceal hemorrhage: N-butyl-2-cyanoacrylate injection versus band ligation
    Pen Chung Tan
    Division of Gastroenterology, Department of Medicine, Veterans General Hospital Taipei and National Yang Ming University School of Medicine, Taipei, Taiwan
    Hepatology 43:690-7. 2006
    ..Severe complications attributable to these two treatments were rare. In conclusion, the efficacy of GVL to control active GVH appears not different to GVO, but GVO is associated with a lower GV rebleeding rate...
  19. ncbi Natural history of portal hypertension in patients with cirrhosis
    R de Franchis
    Department of Internal Medicine, University of Milan, Italy
    Clin Liver Dis 5:645-63. 2001
    ..Acute bleeding from portal hypertensive gastropathy seems to be relatively uncommon, and less severe than bleeding from varices...
  20. ncbi Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis
    Francesco Vizzutti
    Dipartimento di Medicina Interna, Center for Research, Higher Education and Transfer DENOThe, Firenze, Italy
    Hepatology 45:1290-7. 2007
    ....
  21. ncbi Patency of stents covered with polytetrafluoroethylene in patients treated by transjugular intrahepatic portosystemic shunts: long-term results of a randomized multicentre study
    Christophe Bureau
    Federation Digestive Purpan, Service Hepato Gastro Enterologie CHU Toulouse, Toulouse, France
    Liver Int 27:742-7. 2007
    ..In conclusion, the improvement in TIPS patency by using covered prostheses is maintained over time with a decreased risk of encephalopathy, while the risk of death was not increased...
  22. ncbi Banding ligation versus beta-blockers as primary prophylaxis in esophageal varices: systematic review of randomized trials
    Lise L Gluud
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark
    Am J Gastroenterol 102:2842-8; quiz 2841, 2849. 2007
    ..To compare banding ligation versus beta-blockers as primary prophylaxis in patients with esophageal varices and no previous bleeding...
  23. ncbi Endoscopic ligation compared with sclerotherapy for bleeding esophageal varices in children with extrahepatic portal venous obstruction
    Showkat Ali Zargar
    Department of Gastroenterology, Sher I Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India
    Hepatology 36:666-72. 2002
    ..4% vs. 10%, P =.67). In conclusion, variceal band ligation in children is a safe and effective technique that achieves variceal eradication more quickly, with a lower rebleeding rate and fewer complications compared with sclerotherapy...
  24. ncbi Long-term results of balloon-occluded retrograde transvenous obliteration for the treatment of gastric varices and hepatic encephalopathy
    T Fukuda
    Department of Radiology, Kobe University School of Medicine, Japan
    J Vasc Interv Radiol 12:327-36. 2001
    ..To evaluate the long-term results of balloon-occluded retrograde transvenous obliteration (B-RTO) for the treatment of gastric varices (GV) and hepatic encephalopathy...
  25. ncbi Non-invasive predictors of the presence of large oesophageal varices in patients with cirrhosis
    K C Thomopoulos
    Department of Internal Medicine, Division of Gastroenterology University Hospital of Patras, Patras, Greece
    Dig Liver Dis 35:473-8. 2003
    ..The aim of the present study was to determine whether clinical or laboratory non-endoscopic parameters could predict the presence of large oesophageal varices...
  26. ncbi Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial
    Ming Chih Hou
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, No 201 Sec 2 Shih Pai Road, Taipei, Taiwan 11217, ROC
    Hepatology 39:746-53. 2004
    ..In conclusion, antibiotic prophylaxis can prevent infection and rebleeding as well as decrease the amount of blood transfused for patients with acute GEVB following endoscopic treatment...
  27. ncbi [Non-invasive diagnosis of portal hypertension in cirrhosis. Application to the primary prevention of varices]
    Nina Dib
    Laboratoire HIFIH, UPRES EA 3859, IFR 132, Université et Service d Hépato Gastroentérologie, CHU, Angers
    Gastroenterol Clin Biol 29:975-87. 2005
    ....
  28. ncbi Prevention of variceal rebleeding
    Jaume Bosch
    Hepatic Haemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, Hospital Clinic, IDIBAPS, University of Barcelona, 08036, Barcelona, Spain
    Lancet 361:952-4. 2003
    ..Endoscopic techniques include band ligation (EBL) and injection sclerotherapy (EIS). Drug approaches are based on non-selective beta blocker with or without isosorbide-5-mononitrate (ISMN)...
  29. ncbi Endoscopic Doppler US-guided injection therapy for gastric varices: case report
    Giorgio Battaglia
    Department of Medical and Surgical Sciences, IV Surgery Clinic, University of Padova, Italy
    Gastrointest Endosc 57:608-11. 2003
  30. ncbi [Measurement of hepatic venous pressure gradient in liver cirrhosis: relationship with the status of cirrhosis, varices, and ascites in Korea]
    Moon Young Kim
    Department of Internal Medicine and Institute of Lifelong Health, Yonsei University Wonju College of Medicine, Wonju, Korea
    Korean J Hepatol 14:150-8. 2008
    ..The aim of this study was to determine the relationships between HVPG and the complications or status of cirrhosis...
  31. ncbi Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices
    Farhad Kazemi
    Hepatology Department, Hopital Jean Verdier, APHP, Universite Paris 13, Bondy, France
    J Hepatol 45:230-5. 2006
    ..Periodic endoscopic screening for oesophageal varices is recommended in patients with cirrhosis, but might be limited to a subgroup of patients if a simple non-invasive test was available to select those at risk of bleeding...
  32. ncbi Long-term outcomes of acute gastric variceal bleeding in 48 patients following treatment with cyanoacrylate
    Petruska Marques
    Department of Gastroenterology, Gastrointestinal Endoscopy Division, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Dig Dis Sci 53:544-50. 2008
    ..1) Study the effectiveness of intravariceal injection of n-butyl-2-cyanoacrylate to treat acute gastric variceal (GV) bleeding and (2) study the impact of the type of GV and hepatic function on endoscopic hemostasis and mortality outcomes...
  33. ncbi TIPS versus transcatheter sclerotherapy for gastric varices
    Teruhisa Ninoi
    Department of Radiology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    AJR Am J Roentgenol 183:369-76. 2004
    ..The purpose of our study was to compare the efficacy and long-term results of transjugular intrahepatic portosystemic shunt (TIPS) with those of transcatheter sclerotherapy for the treatment of gastric varices...
  34. ncbi Cost-effectiveness of N-butyl-2-cyanoacrylate (histoacryl) glue injections versus transjugular intrahepatic portosystemic shunt in the management of acute gastric variceal bleeding
    S Mahadeva
    Department of Hepatology and Liver Transplantation, St James s University Hospital, Beckett Street, Leeds LS9, United Kingdom
    Am J Gastroenterol 98:2688-93. 2003
    ..Cost-effectiveness analyses of these methods are lacking...
  35. ncbi Cirrhosis and bleeding: the need for very early management
    Delphine Nidegger
    Institut de Santé Publique Faculté de Médecine de Poitiers, Poitiers, France
    J Hepatol 39:509-14. 2003
    ..In a prospective cohort study in which the choice of prophylactic therapy was left to each practitioner, we followed cirrhotic patients with medium/large varices to determine factors predictive of bleeding and death...
  36. ncbi [Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding]
    Jae Woo Kim
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
    Korean J Hepatol 12:394-403. 2006
    ..This study was conducted to evaluate the efficacy of n-butyl-2-cyanoacrylate injection therapy for patients suffering with gastric variceal bleeding...
  37. ncbi A cost-utility analysis of secondary prophylaxis for variceal hemorrhage
    Joel H Rubenstein
    Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan 48109 0362, USA
    Am J Gastroenterol 99:1274-88. 2004
    ..Secondary prophylaxis for esophageal variceal hemorrhage (VH) is recommended, but there has never been a cost-utility analysis of its implementation...
  38. ncbi The effects of cefazolin on cirrhotic patients with acute variceal hemorrhage after endoscopic interventions
    Huang Wei Xu
    Division of Hepato Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung, Kaohsiung 833, Taiwan
    Surg Endosc 25:2911-8. 2011
    ..This study aimed to explore the effects of cefazolin on the outcome of cirrhotic patients with acute variceal hemorrhage after endoscopic interventions...
  39. ncbi Acute management of refractory variceal bleeding in liver cirrhosis by self-expanding metal stents
    A Dechene
    Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
    Digestion 85:185-91. 2012
    ..With this study, we aimed to evaluate the implantation of self-expanding metal stents (SEMS) for the management of therapy-refractory variceal bleeding...
  40. pmc The role of the transjugular intrahepatic portosystemic stent shunt (TIPSS) in the management of bleeding gastric varices: clinical and haemodynamic correlations
    D Tripathi
    Centre for Liver and Digestive Disorders and Department of Medicine, Royal Infirmary of Edinburgh, UK
    Gut 51:270-4. 2002
    ..Although it has been reported that gastric varices can bleed at pressures of < or = 12 mm Hg, this phenomenon has been little studied in the clinical setting...
  41. ncbi Effectiveness of combined pharmacologic and ligation therapy in high-risk patients with acute esophageal variceal bleeding
    Salvador Augustin
    Liver Unit Department of Internal Medicine, Universitat Autonoma de Barcelona, Spain
    Am J Gastroenterol 106:1787-95. 2011
    ..The effectiveness of currently recommended standard therapy (drugs plus endoscopic ligation) for different risk subgroups and the validity of available risk criteria in clinical practice are unknown...
  42. ncbi A randomized controlled trial of cyanoacrylate versus alcohol injection in patients with isolated fundic varices
    Shiv K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 97:1010-5. 2002
    ..A prospective study was undertaken to compare the efficacy and safety of GV sclerotherapy using alcohol and GV obturation using cyanoacrylate glue...
  43. ncbi Balloon-occluded retrograde transvenous obliteration of gastric fundal varices with hemorrhage
    Mikiya Kitamoto
    First Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    AJR Am J Roentgenol 178:1167-74. 2002
    ..This study was performed to evaluate the clinical efficacy, feasibility, and complications of balloon-occluded retrograde transvenous obliteration for patients with hemorrhage from gastric fundal varices...
  44. ncbi Bucrylate treatment of bleeding gastric varices: 12 years' experience
    R Kind
    First Surgical Department, Universita di Verona, Italy
    Endoscopy 32:512-9. 2000
    ..In this study we report on our experience with the use of Bucrylate (Hystoacryl) for the treatment of gastric varices over a period of more than a decade...
  45. ncbi Gastric varices: an updated review of management
    Shayan Irani
    Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA 98111, USA
    J Clin Gastroenterol 45:133-48. 2011
    ..We suggest an algorithm for the management based on the etiology of the gastric varices, severity of the underlying liver disease, and local availability and expertise...
  46. ncbi A prospective, randomized trial of butyl cyanoacrylate injection versus band ligation in the management of bleeding gastric varices
    G H Lo
    Division of Gastroenterology, Department of Medicine, Kaohsiung Veterans General Hospital, National Yang Ming University, Taipei, Taiwan, Republic of China
    Hepatology 33:1060-4. 2001
    ..01). Nine patients of group A and 14 patients of group B died (P = .05). In conclusion, endoscopic obturation using cyanoacrylate proved more effective and safer than band ligation in the management of bleeding gastric varices...
  47. ncbi Propranolol for the prevention of first esophageal variceal hemorrhage: a lifetime commitment?
    D R Abraczinskas
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA
    Hepatology 34:1096-102. 2001
    ..Patients who discontinue beta blockers experience increased mortality compared with an untreated population. These observations support the current practice of indefinite prophylactic therapy...
  48. ncbi Spleen assessment by Acoustic Radiation Force Impulse Elastography (ARFI) for prediction of liver cirrhosis and portal hypertension
    Simona Bota
    Department of Gastroenterology and Hepatology University of Medicine and Pharmacy, Timisoara, Romania
    Med Ultrason 12:213-7. 2010
    ....
  49. ncbi Complications and outcomes in chronic liver disease
    Robert S Rahimi
    Division of Digestive and Liver Disease, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8887, USA
    Curr Opin Gastroenterol 27:204-9. 2011
    ..Studies of the complications, management and outcomes in patients with CLD over the last 18 months are reviewed...
  50. ncbi A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding
    Candid Villanueva
    Gastrointestinal Bleeding Unit, Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Hepatol 45:560-7. 2006
    ..However, which emergency endoscopic treatment combines better with drugs has not been clarified. This study compares the efficacy and safety of variceal ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin...
  51. ncbi Variceal ligation plus nadolol compared with ligation for prophylaxis of variceal rebleeding: a multicenter trial
    Joaquín de la Peña
    Hospital Universitario Marques de Valdecilla, Santander, Spain
    Hepatology 41:572-8. 2005
    ..In conclusion, nadolol plus EVL reduces the incidence of variceal rebleeding compared with EVL alone. A combined treatment could lower the probability of variceal recurrence after eradication...
  52. ncbi Low incidence of complications from endoscopic gastric variceal obturation with butyl cyanoacrylate
    Liu Fang Cheng
    Department of Gastroenterology and Hepatology, Chinese People s Liberation Army General Hospital, Beijing, China
    Clin Gastroenterol Hepatol 8:760-6. 2010
    ..Endoscopic variceal obturation with tissue adhesive is used to control gastric variceal bleeding. We investigated the prevalence of serious complications from this therapy...
  53. ncbi Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study
    Peter Jepsen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Hepatology 51:1675-82. 2010
    ..Subsequent complications occurred in an unpredictable order among patients with ascites or variceal bleeding...
  54. pmc Detection of submucosal gastric fundal varices with multi-detector row CT angiography
    J K Willmann
    Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland
    Gut 52:886-92. 2003
    ..The aim of this study was to evaluate if multi-detector row CT (MDCT) angiography contributes to the diagnosis of submucosal fundal varices...
  55. ncbi Endoscopy critics vs. endoscopy enthusiasts for primary prophylaxis of variceal bleeding
    Roberto de Franchis
    Hepatology 43:24-6. 2006
  56. ncbi Portal hypertensive gastropathy in chronic hepatitis C patients with bridging fibrosis and compensated cirrhosis: results from the HALT-C trial
    Robert J Fontana
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Am J Gastroenterol 101:983-92. 2006
    ....
  57. ncbi Esophageal variceal ligation for acute variceal bleeding: results of three years' follow-up
    Engin Altintas
    Division of Gastroenterology, School of Medicine, Mersin University, Mersin, Turkey
    Turk J Gastroenterol 15:27-33. 2004
    ..However, the rebleeding course and long-term outcome of patients with esophageal variceal hemorrhage after ligation have been poorly defined. Therefore, we conducted a long-term follow-up study to delineate the outcome of ligation...
  58. ncbi Alcohol consumption by cirrhotic subjects: patterns of use and effects on liver function
    Michael R Lucey
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 5124, USA
    Am J Gastroenterol 103:1698-706. 2008
    ....
  59. pmc Balloon-occluded retrograde transvenous obliteration for gastric varices: the relationship between the clinical outcome and gastrorenal shunt occlusion
    Kenichi Katoh
    Department of Radiology, Iwate Medical University, Morioka, Japan
    BMC Med Imaging 10:2. 2010
    ..The purpose of this study is to retrospectively evaluate the technical aspects of B-RTO and the recurrence of gastric varices after treatment with this procedure...
  60. ncbi A standardized injection technique and regimen ensures success and safety of N-butyl-2-cyanoacrylate injection for the treatment of gastric fundal varices (with videos)
    Stefan Seewald
    Department of Interdisciplinary Endoscopy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Gastrointest Endosc 68:447-54. 2008
    ..N-butyl-2-cyanoacrylate has been successfully used for the treatment of bleeding from gastric fundal varices (FV). However, significant rebleeding rates and serious complications including embolism have been reported...
  61. ncbi Development of thrombus in the major systemic and portal veins after balloon-occluded retrograde transvenous obliteration for treating gastric variceal bleeding: its frequency and outcome evaluation with CT
    Sung Ki Cho
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon dong 50, Kangnam Gu, Seoul 135 710, Korea
    J Vasc Interv Radiol 19:529-38. 2008
    ....
  62. ncbi Balloon-occluded retrograde transvenous obliteration improves liver function in patients with cirrhosis and portal hypertension
    Yasunao Miyamoto
    Department of Medicine II, Division of Gastroenterology and Endoscopy, Kurume University School of Medicine, Kurume, Japan
    J Gastroenterol Hepatol 18:934-42. 2003
    ..However, the effects of B-RTO on liver function remain unknown...
  63. ncbi Short-term complications of retrograde transvenous obliteration of gastric varices in patients with portal hypertension: effects of obliteration of major portosystemic shunts
    R Shimoda
    Gastroenterology Division, Maebashi Red Cross Hospital, Maebashi, Japan
    Abdom Imaging 30:306-13. 2005
    ..Thus, B-RTO is a safe and effective management of fundic varices. However, short-term hemodynamic change after B-RTO may cause gastric mucosal damage. Pulmonary infarction and pleural effusion are potential complications...
  64. ncbi Long-term results of balloon-occluded retrograde transvenous obliteration for gastric variceal bleeding and risky gastric varices: a 10-year experience
    Tomohiko Akahoshi
    Departments of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Gastroenterol Hepatol 23:1702-9. 2008
    ..We investigated the long-term effects of B-RTO on rebleeding, prevention of first bleeding, mortality and occurrence of risky esophageal varices (EVx)...
  65. ncbi External validation of the platelet count/spleen diameter ratio for the diagnosis of esophageal varices in hepatitis C virus-related cirrhosis
    Adnan Agha
    Department of Internal Medicine, Medical Unit I, Jinnah Hospital, Allama Iqbal Medical College, Lahore, Pakistan
    Dig Dis Sci 54:654-60. 2009
    ..Screening for esophageal varices (EV) is an important part of the diagnostic workup of cirrhotic patients...
  66. ncbi Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, Centre Hospitalier Universitaire CHU de Bordeaux, Pessac, France
    J Hepatol 50:59-68. 2009
    ....
  67. ncbi Clinical and laboratory predictors of esophageal varices in children and adolescents with portal hypertension syndrome
    Eleonora Druve Tavares Fagundes
    Department of Pediatrics, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Pediatr Gastroenterol Nutr 46:178-83. 2008
    ..To determine the clinical and laboratory parameters that may predict the presence of esophageal varices in children and adolescents with portal hypertension...
  68. ncbi Recent variceal bleeding: Doppler US hepatic vein waveform in assessment of severity of portal hypertension and vasoactive drug response
    Soon Koo Baik
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, 162 Ilsan dong, Wonju 220 701, South Korea
    Radiology 240:574-80. 2006
    ..To prospectively evaluate both the correlation between abnormal Doppler ultrasonography (US) hepatic vein waveforms and the hepatic venous pressure gradient (HVPG) and the response to drug treatment in patients with cirrhosis...
  69. ncbi The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis
    Arun J Sanyal
    Division of Gastroenterology, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Gastrointest Endosc 64:855-64. 2006
    ..The factors predictive of the presence or the absence of esophageal varices in hepatitis C virus (HCV) and advanced fibrosis have not been defined...
  70. ncbi Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis
    Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Yale University School of Medicine and VA CT Healthcare System, New Haven, Connecticut 06520, USA
    Am J Gastroenterol 102:2086-102. 2007
  71. ncbi Diagnosis and monitoring of portal hypertension
    R de Franchis
    Department of Medical Sciences, University of Milan, Italy
    Dig Liver Dis 40:312-7. 2008
    ....
  72. ncbi Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding
    C Villanueva
    Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    N Engl J Med 345:647-55. 2001
    ..We compared two treatments to prevent recurrent bleeding--endoscopic ligation and combined medical therapy with nadolol and isosorbide mononitrate...
  73. pmc Platelet count/spleen diameter ratio: proposal and validation of a non-invasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis
    E Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Italy
    Gut 52:1200-5. 2003
    ....
  74. ncbi The use of self-expanding metal stents to treat acute esophageal variceal bleeding
    R Hubmann
    2nd Dept of Internal Medicine, Linz General Hospital, Linz, Austria
    Endoscopy 38:896-901. 2006
    ..The primary aim of this study was to evaluate the use of self-expandable metallic stents to arrest uncontrollable acute variceal bleeding...
  75. ncbi Endoscopic variceal ligation plus propranolol versus endoscopic variceal ligation alone in primary prophylaxis of variceal bleeding
    Shiv K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 100:797-804. 2005
    ..This prospective randomized controlled trial compared endoscopic variceal ligation (EVL) with propranolol and EVL alone in the prevention of first variceal bleed among patients with high-risk varices...
  76. ncbi The management of portal hypertension: rational basis, available treatments and future options
    Jaime Bosch
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Hospital Clinic, C Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 48:S68-92. 2008
    ....
  77. ncbi Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding
    Alberto Monescillo
    Digestive Disease Department, Hospital Universitario Insular de Gran Canaria, Canary Islands, Spain
    Hepatology 40:793-801. 2004
    ....
  78. pmc Infection, coagulation, and variceal bleeding in cirrhosis
    U Thalheimer
    Liver Transplantation and Hepatobiliary, Medicine Unit, Royal Free Hospital, Pond St, London NW3 2QG, UK
    Gut 54:556-63. 2005
  79. doi Portal hypertension and variceal bleeding--unresolved issues. Summary of an American Association for the study of liver diseases and European Association for the study of the liver single-topic conference
    Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Hepatology 47:1764-72. 2008
  80. pmc Predictors of esophageal varices in patients with HBV-related cirrhosis: a retrospective study
    Wan Dong Hong
    Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, PR China
    BMC Gastroenterol 9:11. 2009
    ..Predicting the presence of EV through non-invasive means may reduce a large number of unnecessary endoscopies. This study was designed to develop a predictive model for varices in patients with Hepatitis B virus-related cirrhosis...
  81. ncbi Prediction of oesophagogastric varices in patients with liver cirrhosis
    F H Ng
    Department of Medicine and Radiology, Ruttonjee Hospital, Hong Kong, China
    J Gastroenterol Hepatol 14:785-90. 1999
    ..All patients with liver cirrhosis are recommended for evaluation of oesophagogastric varices (EGV) regularly. This prospective study was designed to develop a predictive model for EGV in cirrhotic patients...
  82. ncbi Risk factors for the presence of varices in cirrhotic patients without a history of variceal hemorrhage
    A Zaman
    Division of Gastroenterology and Hepatology, PV 310, Oregon Health Sciences University, 3181 Sam Jackson Park Rd, Portland, OR 97201, USA
    Arch Intern Med 161:2564-70. 2001
    ..The aim of this case-control study was to identify clinical, laboratory, and radiologic findings that predict the presence of varices in patients with cirrhosis...
  83. ncbi Treatment of esophageal varices: a randomized controlled trial comparing endoscopic sclerotherapy and EUS-guided sclerotherapy of esophageal collateral veins
    Gustavo Andrade de Paulo
    Endoscopy Unit, Division of Gastroenterology, Universidade Federal de Sao Paulo UNIFESP EPM, Brazil
    Gastrointest Endosc 63:396-402; quiz 463. 2006
    ..Unfortunately, recurrence is common and seems to be related to esophageal collateral vessels, easily identified by EUS. Eradication of these vessels might lead to a more durable therapeutic effect...
  84. ncbi A randomized, controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis
    D Patch
    Department of Liver Transplantation and Hepatobiliary Medicine, University Department of Surgery, Royal Free Hospital Hampstead NHS Trust, London, UK
    Gastroenterology 123:1013-9. 2002
    ..Since its introduction, endoscopic variceal banding has been shown to be superior to needle sclerotherapy. Banding has not been compared with hepatic venous pressure-guided medical therapy (beta-blockers and nitrates)...
  85. ncbi A self-expanding metal stent for complicated variceal hemorrhage: experience at a single center
    Gavin Wright
    Sheila Sherlock Liver Centre, Royal Free Hospital, London, United Kingdom
    Gastrointest Endosc 71:71-8. 2010
    ..Existing salvage techniques such as transjugular intrahepatic portosystemic shunt (TIPS) and balloon tamponade (BT) have important limitations and may not be appropriate for all patients...
  86. ncbi Results of a new method to stop acute bleeding from esophageal varices: implantation of a self-expanding stent
    J Zehetner
    Surgical Department, Academic Teaching Hospital, AKH Linz, Ludwig Boltzmann Institute for Operative Laparoscopy, Krankenhausstrasse 9, 4020 Linz, Austria
    Surg Endosc 22:2149-52. 2008
    ..However, for 10% to 20% of patients, therapy fails to stop the bleeding. This study aimed to assess the SX-ELLA Stent Danis Set (which has a self-expanding metal stent) instead of a balloon probe for compression of esophageal varices...
  87. ncbi Distal splenorenal shunt versus transjugular intrahepatic portal systematic shunt for variceal bleeding: a randomized trial
    J Michael Henderson
    Department of Surgery, Cleveland Clinic, Cleveland, Ohio, USA
    Gastroenterology 130:1643-51. 2006
    ..This prospective randomized trial tested the hypothesis that patients receiving distal splenorenal shunts (DSRS) would have significantly lower rebleeding and encephalopathy rates than TIPS in management of refractory variceal bleeding...
  88. ncbi Prediction of oesophageal varices in hepatic cirrhosis by simple serum non-invasive markers: Results of a multicenter, large-scale study
    Giada Sebastiani
    Department of Digestive Diseases, Hepatology and Clinical Nutrition, Dell Angelo Hospital, Venice, Italy
    J Hepatol 53:630-8. 2010
    ..Preliminary data suggest that non-invasive methods could be useful to assess presence of oesophageal varices (OV) in cirrhotic patients. We aimed to further investigate simple serum non-invasive markers for diagnosing and grading OV...
  89. ncbi Review article: the modern management of portal hypertension--primary and secondary prophylaxis of variceal bleeding in cirrhotic patients
    J C Garcia-Pagan
    Liver Unit, Hepatic Hemodynamic Laboratory, Hospital Clinic, IDIBAPS and Ciberehd, Barcelona, Spain
    Aliment Pharmacol Ther 28:178-86. 2008
    ..Variceal bleeding is a life-threatening complication of liver cirrhosis with a high probability of recurrence. Treatment to prevent first bleeding or rebleeding is mandatory...
  90. ncbi Pharmacological reduction of portal pressure and long-term risk of first variceal bleeding in patients with cirrhosis
    Juan Turnes
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, Hospital Clinic, IDIBAPS, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Am J Gastroenterol 101:506-12. 2006
    ..The aim of this study was to evaluate whether this protective effect is maintained in the long term and if it extends to other portal hypertension complications...
  91. ncbi Retrograde transvenous obliteration of gastric varices associated with large collateral veins or a large gastrorenal shunt
    Kazuya Sugimori
    Gastroenterological Center, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama 232 0024, Japan
    J Vasc Interv Radiol 16:113-8. 2005
    ..There have been no complications or recurrences of gastric varices in any of the patients during the follow-up period...
  92. pmc Noninvasive prediction of large esophageal varices in chronic liver disease patients
    Arulprakash Sarangapani
    Department of Digestive Health and Diseases, Government Peripheral Hospital, Kilpauk Medical College, Chennai 102, India
    Saudi J Gastroenterol 16:38-42. 2010
    ..This prospective study was conducted to evaluate noninvasive predictors of large varices (LV)...
  93. ncbi Prophylactic endoscopic sclerotherapy of large esophagogastric varices in infants with biliary atresia
    Mathieu Duché
    Division of Radiologie, Hopital Bicetre, Le Kremlin Bicetre, France
    Gastrointest Endosc 67:732-7. 2008
    ..Esophageal varices-related GI bleeding occurs frequently and early in life in children with biliary atresia and it may be life threatening...
  94. ncbi Therapeutic effect of balloon-occluded retrograde transvenous obliteration on portal-systemic encephalopathy in patients with liver cirrhosis
    T Kato
    First Department of Internal Medicine, Gifu University School of Medicine
    Intern Med 40:688-91. 2001
    ..Additional B-RTO was required and effective in 2 of them. CONCLUSION: B-RTO is an effective treatment for chronic recurrent hepatic encephalopathy with an angiographically proven portal-systemic shunt...
  95. ncbi The role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension
    Luis Colombato
    Hepatic Hemodynamic Section, Liver Unit, Gastroenterology Department, Buenos Aires British Hospital, Buenos Aires School of Medicine, Buenos Aires University, Buenos Aires, Argentina
    J Clin Gastroenterol 41:S344-51. 2007
    ..Pre-TIPS evaluation taking into account predictors of outcome is mandatory. The improved results achieved with covered-stents might expand the currently accepted recommendations for TIPS use...
  96. pmc Percutaneous paraumbilical embolization as an unconventional and successful treatment for bleeding jejunal varices
    Lee Guan Lim
    Department of Gastroenterology and Hepatology, National University Hospital, 5 Lower Kent Ridge Road, 119074, Singapore 119074, Singapore
    World J Gastroenterol 15:3823-6. 2009
    ..Percutaneous paraumbilical embolization via caput medusa was performed on day 9 of hospitalization. Following the embolization, the hematochezia stopped. However, he defaulted subsequent follow-up...
  97. ncbi Transcatheter obliteration of gastric varices: Part 2. Strategy and techniques based on hemodynamic features
    Hiro Kiyosue
    Department of Radiology, Oita Medical University, 1 1 Hasama, Oita 879 55, Japan
    Radiographics 23:921-37; discussion 937. 2003
    ..The majority of gastric varices can be treated successfully with a combination of these techniques. However, accurate assessment of the variceal hemodynamic pattern is the most important factor in ensuring successful treatment...
  98. ncbi Portal hypertension and variceal hemorrhage
    Nagib Toubia
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, MCV, Box 980341, Richmond, VA 23298 0341, USA
    Med Clin North Am 92:551-74, viii. 2008
    ....
  99. ncbi Incidence and prevalence of cirrhosis in the United Kingdom, 1992-2001: a general population-based study
    Kate M Fleming
    Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
    J Hepatol 49:732-8. 2008
    ..To determine the incidence and prevalence of cirrhosis in the United Kingdom...
  100. ncbi Prediction of large esophageal varices in patients with cirrhosis of the liver using clinical, laboratory and imaging parameters
    Sanjay Kumar Sharma
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 22:1909-15. 2007
    ..This approach leads to unnecessary UGIE in those without LEVx. We tried to identify clinical, laboratory and imaging parameters that may predict the presence of LEVx and help select patients for UGIE...
  101. ncbi Platelet count is not a predictor of the presence or development of gastroesophageal varices in cirrhosis
    Amir A Qamar
    Brigham and Women s Hospital, Boston, MA 02446, USA
    Hepatology 47:153-9. 2008
    ..0374). A significant correlation was found between HVPG and PLT at the baseline, year 1, and year 5 (P < 0.0001)...

Research Grants14

  1. HCV-HIV Coinfection: Impact of Immune Dysfunction
    Richard Sterling; Fiscal Year: 2007
    ..The K-23 award will protect this candidates time and help him mature into a senior investigator in Hepatology. ..
  2. UGI Hemorrhage and Barrett's Epithelium
    Dennis Jensen; Fiscal Year: 2008
    ..This award will continue to enhance the applicant's research productivity and provide skilled mentoring for young investigators, so they can become independent patient-oriented investigators in digestive diseases. ..
  3. MULTICENTER RANDOMIZED TRIAL OF DSRS VERSUS TIPS
    John Henderson; Fiscal Year: 2004
    ..The extension of this trial, will provide the most comprehensive and longest follow-up for these two shunt procedures for control of variceal bleeding. ..
  4. Relationship of metabolic abnormalities to hepatic steatosis in HIV
    Richard Sterling; Fiscal Year: 2008
    ..If our hypothesis is correct, this work could result in a dramatic change in the long-term care of the over 1 million HIV infected individuals in the US. [unreadable] [unreadable]..
  5. Biliary Microlithiasis in Alcohol Induced Pancreatitis
    Arun Sanyal; Fiscal Year: 2007
    ..The long-term goal is to use data from this R21 proposal to develop a RO1 proposal about a large scale phase III clinical trial of UDCA for alcohol-induced pancreatitis. [unreadable] [unreadable] [unreadable]..
  6. NO production and S-nitrosylation in liver vasculature
    Yasuko Iwakiri; Fiscal Year: 2008
    ..The School of Medicine has pledged protected time for the candidate during this further training period prior to functioning as an independent investigator. ..
  7. Molecular Mechanisms of Portal Hypertension
    Vijay Shah; Fiscal Year: 2007
    ..abstract_text> ..
  8. FACTORS IN THE PREVENTION OF TOXIC LIVER INJURY
    Thomas Boyer; Fiscal Year: 2008
    ..The studies will clarify why expression of certain proteins fall during the acute phase response. ..
  9. REG OF NITRIC OXIDE PRODUCT IN THE HEPATIC CIRCULATION
    Vijay Shah; Fiscal Year: 2002
    ..Defining the mechanisms that regulate nitric oxide production in SEC may lead to therapeutic options whereby NO activity may be pharmacologically or genetically modulated and benefit patients with cirrhosis and portal hypertension. ..
  10. Artificial Nutrition in Terminally Ill Cancer Patients
    Sydney Dy; Fiscal Year: 2007
    ..Dy with the skills she needs to develop into an independent clinical researcher in oncology palliative care decision-making and health services research. ..
  11. Failure of FasL Mediated Pathways in Tumor Angiogenesis
    Vijay Shah; Fiscal Year: 2006
    ..These insights may lead to novel and effective therapeutic strategies that target this pathway to prevent angiogenesis, and thereby prevent colorectal tumor development growth and spread. ..
  12. Inhibition of TNF in Patients with Alcoholic Hepatitis
    Vijay Shah; Fiscal Year: 2005
    ..abstract_text> ..
  13. Endothelial Nitric Oxide Synthase & Portal Hypertension
    Vijay Shah; Fiscal Year: 2002
    ..abstract_text> ..
  14. Pathophysiological Interpretations of Dynamic PET/CT of Molecular Liver Biology
    Susanne Keiding; Fiscal Year: 2010
    ..This will lead to improved diagnosis and treatment of the large groups of patients with liver disease and cancer in the liver. ..