gastrointestinal diseases

Summary

Summary: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.

Top Publications

  1. ncbi The functional gastrointestinal disorders and the Rome III process
    Douglas A Drossman
    Division of Gastroenterology and Hepatology, UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Gastroenterology 130:1377-90. 2006
  2. ncbi Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?
    William E Whitehead
    Division of Digestive Diseases and Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 122:1140-56. 2002
  3. ncbi Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications (review)
    Magdy El-Salhy
    Section for Gastroenterology, Institute of Internal Medicine, University of Bergen and Stord Helse Fonna Hospital, 5409 Stord, Norway
    Int J Mol Med 24:727-32. 2009
  4. ncbi The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease
    Stephen M Collins
    The Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 136:2003-14. 2009
  5. ncbi The Incidence and gastrointestinal infectious risk of functional gastrointestinal disorders in a healthy US adult population
    Chad K Porter
    Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    Am J Gastroenterol 106:130-8. 2011
  6. ncbi Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report
    Timothy Buie
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 125:S1-18. 2010
  7. ncbi Comorbidity in irritable bowel syndrome
    William E Whitehead
    Center for Functional GI and Motility Disorders at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7555, USA
    Am J Gastroenterol 102:2767-76. 2007
  8. pmc Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice
    Payel Bhanja
    Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 4:e8014. 2009
  9. ncbi Characterization of Bifidobacterium spp. strains for the treatment of enteric disorders in newborns
    Irene Aloisio
    Department of Agroenvironmental Sciences and Technologies, University of Bologna, Italy
    Appl Microbiol Biotechnol 96:1561-76. 2012
  10. ncbi The role of C-reactive protein as an inflammatory marker in gastrointestinal diseases
    Severine Vermeire
    Department of Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Nat Clin Pract Gastroenterol Hepatol 2:580-6. 2005

Detail Information

Publications359 found, 100 shown here

  1. ncbi The functional gastrointestinal disorders and the Rome III process
    Douglas A Drossman
    Division of Gastroenterology and Hepatology, UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Gastroenterology 130:1377-90. 2006
  2. ncbi Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?
    William E Whitehead
    Division of Digestive Diseases and Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 122:1140-56. 2002
    ..The aims of this study were to (1) assess comorbidity in 3 areas: gastrointestinal disorders, psychiatric disorders, and nongastrointestinal somatic disorders; and (2) evaluate explanatory hypotheses...
  3. ncbi Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications (review)
    Magdy El-Salhy
    Section for Gastroenterology, Institute of Internal Medicine, University of Bergen and Stord Helse Fonna Hospital, 5409 Stord, Norway
    Int J Mol Med 24:727-32. 2009
    ..Ghrelin has been reported to be affected in several gastrointestinal diseases/disorders such as inflammatory bowel disease, coeliac disease, infectious diseases, functional disorders ..
  4. ncbi The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease
    Stephen M Collins
    The Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 136:2003-14. 2009
    ..Gaining a better understanding of the relationship between behavior and the microbiota could provide insight into the pathogenesis of functional and inflammatory bowel disorders...
  5. ncbi The Incidence and gastrointestinal infectious risk of functional gastrointestinal disorders in a healthy US adult population
    Chad K Porter
    Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    Am J Gastroenterol 106:130-8. 2011
    ..Within the active duty military population, a group with known high IGE rates, the population-based incidence, risk factors, and attributable burden of care referable to FGD after IGE are poorly defined...
  6. ncbi Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report
    Timothy Buie
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 125:S1-18. 2010
    ..For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs...
  7. ncbi Comorbidity in irritable bowel syndrome
    William E Whitehead
    Center for Functional GI and Motility Disorders at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7555, USA
    Am J Gastroenterol 102:2767-76. 2007
    ..Comorbid nongastrointestinal symptoms account for two-thirds of excess health-care costs in irritable bowel syndrome (IBS)...
  8. pmc Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice
    Payel Bhanja
    Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 4:e8014. 2009
    ....
  9. ncbi Characterization of Bifidobacterium spp. strains for the treatment of enteric disorders in newborns
    Irene Aloisio
    Department of Agroenvironmental Sciences and Technologies, University of Bologna, Italy
    Appl Microbiol Biotechnol 96:1561-76. 2012
    ..longum strain as potential probiotics for the treatments of enteric disorders in newborns such as infantile colics. A validation clinical trial involving the selected strains is being planned...
  10. ncbi The role of C-reactive protein as an inflammatory marker in gastrointestinal diseases
    Severine Vermeire
    Department of Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Nat Clin Pract Gastroenterol Hepatol 2:580-6. 2005
    ..CRP is an objective marker of inflammation and, in gastrointestinal diseases such as Crohn's disease and acute pancreatitis, its levels correlate well with clinical disease activity...
  11. pmc Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases
    Rudolf Schicho
    Medical University of Graz, Austria
    Can J Gastroenterol 25:377-83. 2011
    ..Drugs that inhibit endocannabinoid degradation and raise the level of endocannabinoids are becoming increasingly promising alternative therapeutic tools to manipulate the ECS...
  12. pmc Rapidly measured indicators of recreational water quality and swimming-associated illness at marine beaches: a prospective cohort study
    Timothy J Wade
    United States Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina, USA
    Environ Health 9:66. 2010
    ..In this paper, we report on results from three marine beach sites...
  13. ncbi Pancreatic stone protein/regenerating protein family in pancreatic and gastrointestinal diseases
    Chun Xiang Jin
    The First Clinical College of Norman Bethune Medical Division, Jilin University, China
    Intern Med 50:1507-16. 2011
    ..Evidence obtained can be applied in the prediction of prognosis and therapy for inflammatory and neoplastic diseases...
  14. pmc Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis
    Angel Lanas
    University of Zaragoza Medical School, Aragón Health Research Institute, CIBERehd, Zaragoza, Spain
    BMC Med 9:38. 2011
    ..We aimed to assess the GI/CV risk profile and the pharmacological management of patients with osteoarthritis (OA) in clinical practice...
  15. pmc Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems
    Annika Reintam Blaser
    Clinic of Anaesthesiology and Intensive Care, University of Tartu, Puusepa 8, 51014 Tartu, Estonia
    Intensive Care Med 38:384-94. 2012
    ..An international working group convened to standardize the definitions for acute GI failure and GI symptoms and to review the therapeutic options...
  16. ncbi Impact of rikkunshito, an herbal medicine, on delayed gastric emptying in profoundly handicapped patients
    Hisayoshi Kawahara
    Department of Pediatric Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo cho Izumi, Osaka, 594 1101, Japan
    Pediatr Surg Int 25:987-90. 2009
    ..Rikkunshito is used to treat functional dyspepsia in adults. This study investigated the effects of rikkunshito on delayed gastric emptying in handicapped patients...
  17. pmc Mast cells
    Terez Shea-Donohue
    Department of Medicine and Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Curr Gastroenterol Rep 12:349-57. 2010
    ..The purpose of this review article is to summarize and highlight the latest findings in mast cell biology associated with intestinal homeostasis and pathologies...
  18. ncbi Burden of acute gastrointestinal illness in Denmark 2009: a population-based telephone survey
    L Muller
    Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark
    Epidemiol Infect 140:290-8. 2012
    ..The incidence rate estimates were considerably higher when calculated from shorter recall periods...
  19. ncbi Acute and long-term gastrointestinal consequences of chemotherapy
    Frederic Di Fiore
    Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 23:113-24. 2009
    ..We herein review and discuss the main acute and late gastrointestinal toxicities of chemotherapy and/or radiotherapy for patients with gastrointestinal malignancies...
  20. pmc Development of functional gastrointestinal disorders after Giardia lamblia infection
    Kurt Hanevik
    Institute of Medicine, University of Bergen, Bergen, Norway
    BMC Gastroenterol 9:27. 2009
    ..This study aims to characterize persistent abdominal symptoms elicited by Giardia infection according to Rome II criteria and symptoms scores...
  21. ncbi Review article: gender-related differences in functional gastrointestinal disorders
    E A Mayer
    CURE Neuroenteric Disease Program, UCLA Division of Digestive Diseases, USA
    Aliment Pharmacol Ther 13:65-9. 1999
    ....
  22. ncbi PASSCLAIM--gut health and immunity
    John H Cummings
    Pathology and Neuroscience, University of Dundee Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Eur J Nutr 43:II118-II173. 2004
    ..The digestive tract is most frequently the object of functional and health claims and a large market already exists for gut-functional foods worldwide...
  23. ncbi Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis
    Sanjaykumar Hapani
    Division of Hematology and Medical Oncology, Department of Medicine, Stony Brook University Medical Center, Stony Brook, NY 11794 9447, USA
    Lancet Oncol 10:559-68. 2009
    ..We did a systematic review and meta-analysis of published randomised controlled trials to assess the overall risk of gastrointestinal perforation associated with bevacizumab treatment...
  24. ncbi Pathogenic mechanisms of postinfectious functional gastrointestinal disorders: results 3 years after gastroenteritis
    Fermin Mearin
    Institute of Functional and Motor Digestive Disorders, Centro Medico Teknon, Barcelona, Spain
    Scand J Gastroenterol 44:1173-85. 2009
    ..The aim of this study was to evaluate the possible mechanisms (inflammation, visceral hypersensitivity, psychological and immunogenetic factors) related to the development of postinfectious (PI) FGID 3 years after a Salmonella outbreak...
  25. ncbi Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes in South African patients with upper gastrointestinal diseases
    Nicoline F Tanih
    Microbial Pathogenicity and Molecular Epidemiology Research Group, Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X 1314, Alice 5700, South Africa
    Acta Trop 116:68-73. 2010
    ..Twenty-six percent of the strains identified had both iceA1 and iceA2. All our strains tested positive for the ureC (glmM) gene. This study reveals a high prevalence of vacA, cagA and iceA2...
  26. ncbi The impact of physical exercise on the gastrointestinal tract
    Erick Prado de Oliveira
    Centre for Physical Exercise and Nutrition Metabolism, UNESP School of Medicine, Public Health Department, Botucatu City, Sao Paulo State, Brazil
    Curr Opin Clin Nutr Metab Care 12:533-8. 2009
    ..This review focuses on mechanisms involved in those symptoms and their associations with type of exercises in humans...
  27. pmc Gastrointestinal flora and gastrointestinal status in children with autism--comparisons to typical children and correlation with autism severity
    James B Adams
    School for Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, USA
    BMC Gastroenterol 11:22. 2011
    ..Children with autism have often been reported to have gastrointestinal problems that are more frequent and more severe than in children from the general population...
  28. ncbi Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial
    E Guillemard
    Danone Research, Centre de Recherche Daniel Carasso, Palaiseau Cedex, France
    Br J Nutr 103:58-68. 2010
    ..casei DN-114 001 in elderly was associated with a decreased duration of CID in comparison with the control group, especially for URTI such as rhinopharyngitis...
  29. pmc Improved detection of five major gastrointestinal pathogens by use of a molecular screening approach
    Richard F De Boer
    Laboratory for Infectious Diseases, Department of Research and Development, Groningen, Netherlands
    J Clin Microbiol 48:4140-6. 2010
    ..In conclusion, an MSA for detection of gastrointestinal pathogens resulted in markedly improved detection rates and a substantial decrease in time to reporting of (preliminary) results...
  30. ncbi Anti-tumor necrosis factor monoclonal antibody therapy for gastrointestinal Behçet's disease: a case report
    P V Hassard
    Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Los Angeles, California, USA
    Gastroenterology 120:995-9. 2001
    ..This report suggests that infliximab may be an effective new therapy for gastrointestinal BD, and perhaps other manifestations of BD as well...
  31. ncbi Surveillance for waterborne disease outbreaks associated with drinking water---United States, 2007--2008
    Joan M Brunkard
    Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA 30333, USA
    MMWR Surveill Summ 60:38-68. 2011
    ..This surveillance system is the primary source of data concerning the scope and health effects of waterborne disease outbreaks in the United States...
  32. ncbi Is coeliac disease screening in risk groups justified? A fourteen-year follow-up with special focus on compliance and quality of life
    M Viljamaa
    Department of Gastroenterology, Tampere University Hospital, UKK Institute for Health Promotion Research, School of Public Health, Medical School, University of Tampere, Finland
    Aliment Pharmacol Ther 22:317-24. 2005
    ..The benefits of serologic screening for coeliac disease in asymptomatic individuals are debatable...
  33. ncbi Management of patients on nonsteroidal anti-inflammatory drugs: a clinical practice recommendation from the First International Working Party on Gastrointestinal and Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs and Anti-platelet Agents
    Francis K L Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong
    Am J Gastroenterol 103:2908-18. 2008
    ..Prescribing nonsteroidal antiinflammatory drugs (NSAIDs) is challenging because physicians have to consider gastrointestinal (GI) and cardiovascular (CV) safety issues...
  34. pmc Age and alarm symptoms do not predict endoscopic findings among patients with dyspepsia: a multicentre database study
    M B Wallace
    Digestive Disease Center, Medical University of South Carolina, USA
    Gut 49:29-34. 2001
    ..Better clinical prediction strategies are needed to identify patients with significant upper gastrointestinal pathology...
  35. ncbi Adherence to proton pump inhibitors or H2-receptor antagonists during the use of non-steroidal anti-inflammatory drugs
    M C J M Sturkenboom
    Department of Epidemiology and Biostatistics, Medical Informatics, Erasmus University, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 18:1137-47. 2003
    ..The efficacy of proton pump inhibitors (PPIs) or histamine-2 receptor antagonists (H2RAs) prescribed as prophylaxis for NSAID-related upper gastrointestinal (UGI) toxicity is dependent upon patient adherence...
  36. ncbi 5-HT4 receptor agonists: similar but not the same
    J H De Maeyer
    Movetis NV, Turnhout, Belgium
    Neurogastroenterol Motil 20:99-112. 2008
    ..Selective 5-HT(4) receptor agonists might thus prove to be innovative drugs with an attractive safety profile for better treatment of patients suffering from hypomotility disorders...
  37. ncbi Autism spectrum disorders: concurrent clinical disorders
    - Xue Ming
    Department of Neuroscience, University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ, USA
    J Child Neurol 23:6-13. 2008
    ..There may be common pathophysiologic mechanisms resulting in clinical subgroups of autism spectrum disorders. Recognition of the co-occurrence of concurrent disorders may provide insight into the therapeutic strategy...
  38. ncbi Saccharomyces boulardii effects on gastrointestinal diseases
    Galliano Zanello
    Institut National de la Recherche Agronomique INRA, UR1282, Infectiologie Animale et Sante Publique, F 37380, Nouzilly Tours, France
    Curr Issues Mol Biol 11:47-58. 2009
    ..They include the treatment and the prevention of gastrointestinal diseases, vaginal and urinary infections and allergies...
  39. ncbi Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases
    Alessio Fasano
    Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Clin Pract Gastroenterol Hepatol 2:416-22. 2005
    ..This review is timely given the increased interest in the role of a 'leaky gut' in the pathogenesis of gastrointestinal diseases and the advent of novel treatment strategies, such as the use of probiotics.
  40. pmc Chronic gastrointestinal symptoms and quality of life in the Korean population
    Jeong Jo Jeong
    Division of Gastroenterology, Department of Internal Medicine, Kangnam St Mary s Hospital, The Catholic University of Korea, 137 040, 505, Banpo dong, Seocho Gu, Seoul 137 040, South Korea
    World J Gastroenterol 14:6388-94. 2008
    ..To evaluate the prevalence of chronic gastrointestinal symptoms and their impact on health-related quality of life (HRQOL) in the Korean population...
  41. pmc Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications
    Sonia Hernandez-Diaz
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    BMC Med 4:22. 2006
    ....
  42. ncbi The serotonin signaling system: from basic understanding to drug development for functional GI disorders
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Gastroenterology 132:397-414. 2007
    ..The initial success encountered with serotonergic agents holds promise for newer and more potent insights and therapies of brain-gut disorders...
  43. ncbi Validation of the pediatric Rome II criteria for functional gastrointestinal disorders using the questionnaire on pediatric gastrointestinal symptoms
    Arlene Caplan
    Department of Psychology, Universite de Montreal, Montreal, Canada
    J Pediatr Gastroenterol Nutr 41:305-16. 2005
    ..To validate the pediatric Rome II criteria for functional gastrointestinal disorders (FGIDs) using the Questionnaire on Pediatric Gastrointestinal Symptoms (QPGS)...
  44. ncbi The burden of selected digestive diseases in the United States
    Robert S Sandler
    University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
    Gastroenterology 122:1500-11. 2002
    ..This study was undertaken to estimate the economic burden of GI and liver disease in the United States for use by policy makers, health care providers, and the public...
  45. pmc Drinking water turbidity and emergency department visits for gastrointestinal illness in Atlanta, 1993-2004
    Sarah C Tinker
    Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Expo Sci Environ Epidemiol 20:19-28. 2010
    ....
  46. ncbi Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study
    Smita L S Halder
    Dyspepsia Center, Enteric Neuroscience Program, Division of Gastroenterology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 133:799-807. 2007
    ..The natural history of FGID is unknown because of a lack of prospective population-based studies and the indistinct nature of the phenotype. We sought to report the natural history of FGID in a US population...
  47. ncbi Probiotics and gastrointestinal diseases
    A Sullivan
    Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 257:78-92. 2005
    ..number of clinical trials have been performed to evaluate the effects in the prevention and treatment of gastrointestinal diseases caused by pathogenic microorganisms or by disturbances in the normal microflora...
  48. ncbi Are anxiety and depression related to gastrointestinal symptoms in the general population?
    T Tangen Haug
    Dept of Psychiatry, Haukeland Hospital, University of Bergen, Norway
    Scand J Gastroenterol 37:294-8. 2002
    ..The results may be biased, however, since anxiety and depression will influence the decision to consult a doctor. The aim of this study was to investigate the relationship between these symptoms in the population...
  49. pmc Brain imaging approaches to the study of functional GI disorders: a Rome working team report
    E A Mayer
    Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 21:579-96. 2009
    ..The article concludes with a critical assessment of published studies, and with recommendations for improved study paradigms and analysis strategies...
  50. ncbi Acute and late complications after radiotherapy for prostate cancer: results of a multicenter randomized trial comparing 68 Gy to 78 Gy
    Stephanie T H Peeters
    Department of Radiotherapy, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 61:1019-34. 2005
    ..To compare acute and late gastrointestinal (GI) and genitourinary (GU) side effects in prostate cancer patients randomized to receive 68 Gy or 78 Gy...
  51. ncbi Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 18:439-56. 2004
    ..Defective ghrelin signaling from the stomach could contribute to abnormalities in energy balance, growth, and associated gastrointestinal and neuroendocrine functions...
  52. ncbi The herbal medicine Rikkunshi-to stimulates and coordinates the gastric myoelectric activity in post-operative dyspeptic children after gastrointestinal surgery
    M Yagi
    Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Niigata, Japan
    Pediatr Surg Int 19:760-5. 2004
    ..The coordinating and stimulating effect of TJ-43 on the gastric myoelectric activity therefore seems to play an important role in the reduction of dyspeptic symptoms...
  53. ncbi Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks
    A Rostom
    Division of Gastroenterology, University of Calgary Medical Clinic, AB, Canada
    Aliment Pharmacol Ther 29:481-96. 2009
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used, but are not without risks...
  54. ncbi Review article: bifidobacteria as probiotic agents -- physiological effects and clinical benefits
    C Picard
    Danone Vitapole, Centre de Recherche Daniel Carasso, Nutrivaleur, Palaiseau, France
    Aliment Pharmacol Ther 22:495-512. 2005
    ..Bifidobacteria may exert protective intestinal actions through various mechanisms, and represent promising advances in the fields of prophylaxis and therapy...
  55. ncbi Validation of Rome II criteria for functional gastrointestinal disorders by factor analysis of symptoms in Asian patient sample
    Ambrose Chi Pong Kwan
    Princess Margaret Hospital, Department of Medicine and Geriatrics, Hong Kong, China
    J Gastroenterol Hepatol 18:796-802. 2003
    ..The aim of the present study was to determine if symptoms of Asian patients with functional gastrointestinal disorders formed groups which corresponded to the Rome II diagnostic criteria...
  56. ncbi AGA technical review on osteoporosis in gastrointestinal diseases
    Charles N Bernstein
    Department of Internal Medicine and Inflammatory Bowel Disease Clinical and Research Centre University of Manitoba Winnipeg, Manitoba, Canada
    Gastroenterology 124:795-841. 2003
  57. ncbi Prospects for the use of probiotic bacteria in the treatment of gastrointestinal diseases in dogs
    M Chrzastowska
    Clinical Diagnostics Unit of the Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, ul Oczapowskiego 14, 10 957 Olsztyn
    Pol J Vet Sci 12:279-84. 2009
    ..Lactobacillus and Enterococcus are capable of colonizing the alimentary tract in dogs. As a result, probiotic bacteria take an important part in the treatment of chronic inflammatory bowel disease...
  58. pmc Rome II versus Rome III classification of functional gastrointestinal disorders in pediatric chronic abdominal pain
    Kari F Baber
    Department of Pediatrics, Division of Adolescent Medicine and Behavioral Science, Vanderbilt University Medical Center, Nashville, TN, USA
    J Pediatr Gastroenterol Nutr 47:299-302. 2008
    ..The purpose of this study was to compare classification results using Rome II versus Rome III criteria for FGIDs associated with chronic abdominal pain...
  59. ncbi Generalized anxiety disorder and medical illness
    Larry Culpepper
    Boston Medical Center, 1 Boston Medical Center Place, Dowling 5, Boston, MA 02118, USA
    J Clin Psychiatry 70:20-4. 2009
    ..Comorbid medical illnesses may influence treatment choice for GAD. Treatment of anxiety in young patients with GAD needs to be long-term to decrease vulnerability to medical conditions...
  60. pmc Central processing of gut pain in diabetic patients with gastrointestinal symptoms
    Jens Brøndum Frøkjaer
    Mech Sense, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Diabetes Care 32:1274-7. 2009
    ..To evaluate the brain's responses to painful visceral and somatic stimuli in diabetic patients with gastrointestinal symptoms...
  61. ncbi Dyspepsia: organic versus functional
    Pantelis Oustamanolakis
    Department of Pathophysiology, Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Belgium
    J Clin Gastroenterol 46:175-90. 2012
    ..The management of uninvestigated and FD, as well as the established and new pharmaceutical agents, is also discussed...
  62. ncbi Systematic review: adipose tissue, obesity and gastrointestinal diseases
    B J John
    Department of Colorectal Surgery, Mayday University Hospital, Croydon, UK
    Aliment Pharmacol Ther 23:1511-23. 2006
    ..The recognition that intra-abdominal fat is immunologically active sheds new light not only on the pathogenesis of obesity-related gastrointestinal conditions, but also on inflammatory conditions such as Crohn's disease...
  63. ncbi Gastrointestinal basidiobolomycosis, an emerging infection in the immunocompetent host: a report of 14 patients
    Bita Geramizadeh
    Transplant Research Center, Shiraz University of Medical Sciences, PO BOX 71345 1864, Shiraz, Iran
    J Med Microbiol 61:1770-4. 2012
    ..Diagnosis of this disease requires a high index of suspicion in patients presenting with abdominal symptoms, fever, gastrointestinal mass and eosinophilia accompanied by a high erythrocyte sedimentation rate...
  64. ncbi Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndrome
    A K Campbell
    Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF103NB, UK
    Toxicology 278:268-76. 2010
    ..We propose it will lead to a new understanding of the molecular mechanism of type 2 diabetes and some cancers...
  65. pmc Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials
    Angel Lanas
    University of Zaragoza Medical School, Aragn Health Research Institute IIS Aragn, CIBERehd, Zaragoza, Spain
    Drugs R D 11:277-88. 2011
    ..The aim of this study was to provide data on the safety of this treatment pattern, which is of interest to clinicians, regulators, and the public...
  66. ncbi Herd-level risk factors for antimicrobial demanding gastrointestinal diseases in Danish herds with finisher pigs: A register-based study
    G K Hybschmann
    Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, Denmark
    Prev Vet Med 98:190-7. 2011
    ..This illustrates the difficulties of characterising AM-demanding GI diseases in herds by the use of register data only...
  67. ncbi A 13-nation population survey of upper gastrointestinal symptoms: prevalence of symptoms and socioeconomic factors
    S Haag
    Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
    Aliment Pharmacol Ther 33:722-9. 2011
    ..However, there is a lack of studies which assess and compare the prevalence of upper gastrointestinal symptoms contemporaneously in various countries using a uniform, standardised method...
  68. ncbi The implication of adiponectin and resistin in gastrointestinal diseases
    Elisavet K Tiaka
    Department of Gastroenterology, University of Thessaly, University Hospital of Larissa, School of Medicine, Greece
    Cytokine Growth Factor Rev 22:109-19. 2011
    ..In the present review, eligible studies focusing on the role of adiponectin and resistin in gastrointestinal diseases are manifested together and classified according to anatomic criteria...
  69. ncbi A metaanalysis of severe upper gastrointestinal complications of nonsteroidal antiinflammatory drugs
    Joshua J Ofman
    Southern California Evidence Based Practice Center, Department of Medicine, Cedars Sinai Health System, Beverly Hills 90212, USA
    J Rheumatol 29:804-12. 2002
    ..We synthesized the published and unpublished evidence to determine the least biased estimates of the risks of perforations, ulcers, and bleeds (PUB) associated with NSAID use from all study designs and all languages...
  70. ncbi Abdominal pain-predominant functional gastrointestinal diseases in children and adolescents: prevalence, symptomatology, and association with emotional stress
    Niranga Manjuri Devanarayana
    Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    J Pediatr Gastroenterol Nutr 53:659-65. 2011
    ..We assessed the prevalence of abdominal pain-predominant FGD, in addition to the predisposing factors and symptomatology, in Sri Lankan children...
  71. ncbi Prevalence of functional gastrointestinal disorders in Taiwan: questionnaire-based survey for adults based on the Rome III criteria
    Fang Yuan Chang
    Children s Medical Center, Taipei Veterans General Hospital, Taipei, 11217 Taiwan, ROC
    Asia Pac J Clin Nutr 21:594-600. 2012
    ..Subjects who met the Rome III criteria for FGID in Taiwan were younger, had less vegetables and fruits intake, higher BSRS scores and were of greater female predominance...
  72. ncbi Co-morbidities in established rheumatoid arthritis
    Nicola J Gullick
    Department of Rheumatology, King s College London School of Medicine, Weston Education Centre, United Kingdom
    Best Pract Res Clin Rheumatol 25:469-83. 2011
    ....
  73. pmc A school-based study with Rome III criteria on the prevalence of functional gastrointestinal disorders in Chinese college and university students
    Yan Yan Dong
    Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    PLoS ONE 8:e54183. 2013
    ..Functional gastrointestinal disorders, including functional dyspepsia, irritable bowel syndrome and functional constipation are very common worldwide...
  74. ncbi Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 25:252-8. 2010
    ..The link between food intake and symptom induction is recognized. This review aims to describe the evidence base for restricting rapidly fermentable, short-chain carbohydrates (FODMAPs) in controlling such symptoms...
  75. ncbi Population-based estimate of the burden of acute gastrointestinal illness in Jiangsu province, China, 2010-2011
    Y J Zhou
    Institute of Food Safety and Assessment, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People s Republic of China
    Epidemiol Infect 141:944-52. 2013
    ..These results highlight the substantial burden of AGI and the risk factors associated with AGI in Jiangsu province, China...
  76. pmc Prevalence of depressive and anxiety disorders in Chinese gastroenterological outpatients
    Xiao Jing Li
    Mental Health Center of West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 18:2561-8. 2012
    ..To investigate the prevalence and physicians' detection rate of depressive and anxiety disorders in gastrointestinal (GI) outpatients across China...
  77. ncbi Acute gastrointestinal illness in New Zealand: a community study
    S B Adlam
    Population and Environmental Health Programme, Institute of Environmental Science and Research Ltd, Kenepuru, New Zealand
    Epidemiol Infect 139:302-8. 2011
    ..This represents a significant burden of disease...
  78. pmc Association between rainfall and pediatric emergency department visits for acute gastrointestinal illness
    Patrick Drayna
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Environ Health Perspect 118:1439-43. 2010
    ..Microbial water contamination after periods of heavy rainfall is well described, but its link to acute gastrointestinal illness (AGI) in children is not well known...
  79. ncbi Assessment of health risks with reference to oxidative stress and DNA damage in chromium exposed population
    Faizan Haider Khan
    Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow 226007, India
    Sci Total Environ 430:68-74. 2012
    ..Our results concluded that the Cr(III) exposed population is at high risk for health hazards and the female population is slightly more susceptible to Cr(III) exposure...
  80. ncbi Emergence of gastrointestinal basidiobolomycosis in the United States, with a review of worldwide cases
    Holenarasipur R Vikram
    Division of Infectious Diseases, Mayo Clinic Hospital, 5777 E Mayo Blvd, Phoenix, AZ 85054, USA
    Clin Infect Dis 54:1685-91. 2012
    ..We examined the epidemiology, clinical manifestations, histopathology, management, and outcomes of gastrointestinal basidiobolomycosis, an uncommon manifestation of infection caused by the fungus Basidiobolus ranarum...
  81. ncbi Ethnoveterinary uses of medicinal plants: a survey of plants used in the ethnoveterinary control of gastro-intestinal parasites of goats in the Eastern Cape Province, South Africa
    Viola Maphosa
    Department of Livestock and Pasture Sciences, University of Fort Hare, Alice, South Africa
    Pharm Biol 48:697-702. 2010
    ..If their safety and efficacy could be confirmed, these plants could form an alternative cost effective strategy in managing helminthiasis in the province...
  82. ncbi A novel composite endpoint to evaluate the gastrointestinal (GI) effects of nonsteroidal antiinflammatory drugs through the entire GI tract
    Francis K L Chan
    The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    J Rheumatol 37:167-74. 2010
    ..The objective of this report is to introduce a novel composite endpoint that measures damage to the entire GI tract - clinically significant upper and lower GI events (CSULGIE) - in patients with NSAID-induced GI damage...
  83. ncbi Effectiveness of national provider prescription of PPI gastroprotection among elderly NSAID users
    Neena S Abraham
    Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
    Am J Gastroenterol 103:323-32. 2008
    ..Our aim was to quantify the effect of provider adherence on the risk of NSAID-related upper gastrointestinal events (UGIE)...
  84. pmc Hospitalization of the elderly in the United States for nonspecific gastrointestinal diseases: a search for etiological clues
    Kenneth K H Chui
    Department of Public Health and Community Medicine, Tufts University School of Medicine Boston, MA 02111, USA
    Am J Public Health 101:2082-6. 2011
    The frequency of hospitalization among the elderly in the United States caused by gastrointestinal diseases between 1991 and 2004 increased dramatically, especially hospitalization of elderly individuals with nonspecific diagnoses...
  85. pmc Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era
    Geoffrey A Preidis
    Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA
    Gastroenterology 136:2015-31. 2009
    ....
  86. ncbi Probiotics in the gastrointestinal diseases of the elderly
    G Malaguarnera
    Department of Microbiology, University of Catania, Catania, Italy
    J Nutr Health Aging 16:402-10. 2012
    ....
  87. pmc A meta-analysis of probiotic efficacy for gastrointestinal diseases
    Marina L Ritchie
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 7:e34938. 2012
    Meta-analyses on the effects of probiotics on specific gastrointestinal diseases have generally shown positive effects on disease prevention and treatment; however, the relative efficacy of probiotic use for treatment and prevention ..
  88. ncbi Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms
    Paul Ashwood
    Department of Medical Microbiology and Immunology, University of California at Davis, M I N D Institute, Wet Lab Building, 50th Street, Sacramento, CA 95817, USA
    J Neuroimmunol 173:126-34. 2006
    ..007) in ASD compared with NIC. There is a unique pattern of peripheral blood and mucosal CD3+ lymphocytes intracellular cytokines, which is consistent with significant immune dysregulation, in this ASD cohort...
  89. ncbi Prevalence of functional gastrointestinal diseases in a cohort of Sri Lankan adolescents: comparison between Rome II and Rome III criteria
    Niranga Manjuri Devanarayana
    Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    J Trop Pediatr 57:34-9. 2011
    Little is known about the prevalence of functional gastrointestinal diseases (FGDs) in adolescents, especially in developing countries...
  90. pmc Health care seeking for abdominal bloating and visible distention
    X Jiang
    Department of Internal Medicine and Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
    Aliment Pharmacol Ther 30:775-83. 2009
    ..While knowledge has accumulated regarding health care seeking in several functional gastrointestinal disorders (FGIDs), little is known about health care seeking in those with bloating and distention...
  91. pmc Design and validation of an oligonucleotide probe for the detection of protozoa from the order Trichomonadida using chromogenic in situ hybridization
    Meike Marissa Mostegl
    Institute of Pathology and Forensic Veterinary Medicine, Department of Pathobiology, University of Veterinary Medicine, Veterinarplatz 1, 1210 Vienna, Austria
    Vet Parasitol 171:1-6. 2010
    ..The probe presented here can be considered an important tool for diagnosis of all to date described relevant protozoal parasites of the order Trichomonadida in tissue samples...
  92. ncbi Appearance and disappearance of functional gastrointestinal disorders in patients with eating disorders
    Catherine Boyd
    Department of Obstetrics and Gynaecology, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia
    Neurogastroenterol Motil 22:1279-83. 2010
    ..The aims were to evaluate the turnover of FGIDs in patients with ED, and to relate this turnover to changes in body mass index (BMI), ED behaviors, and psychological variables...
  93. ncbi Promotility medications--now and in the future
    G Karamanolis
    Center for Gastroenterological Research, KU Leuven, Leuven, Belgium
    Dig Dis 24:297-307. 2006
    ....
  94. pmc Association of H pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases
    Eskandar Kamali-Sarvestani
    Department of Immunology and Autoimmune Diseases Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
    World J Gastroenterol 12:5205-10. 2006
    ..To find out if a functional promoter polymorphism in the IL-8 gene along with cagA status and polymorphisms in vacA gene influence the type of diseases in Iranian patients infected by H pylori...
  95. ncbi Mechanisms underlying gut dysfunction in a murine model of chronic parasitic infection
    Yasuaki Motomura
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
    Am J Physiol Gastrointest Liver Physiol 299:G1354-60. 2010
    ....
  96. ncbi The prevalence of health care-associated infection in older people in acute care hospitals
    Shona Cairns
    Health Protection Scotland, Glasgow, UK
    Infect Control Hosp Epidemiol 32:763-7. 2011
    ..To determine the prevalence of health care-associated infection (HAI) in older people in acute care hospitals, detailing the specific types of HAI and specialties in which these are most prevalent...
  97. pmc Gastrointestinal failure score in critically ill patients: a prospective observational study
    Annika Reintam
    Clinic of Anaesthesiology and Intensive Care, University of Tartu, Puusepa, Tartu 51014, Estonia
    Crit Care 12:R90. 2008
    ..The prognostic value of the GIF score alone and in combination with the Sequential Organ Failure Assessment (SOFA) score is evaluated, and the incidence and outcome of gastrointestinal failure is described relative to the GIF score...
  98. pmc Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease
    Elliott Vichinsky
    Children s Hospital and Research Center at Oakland, Oakland, CA 94609, USA
    Br J Haematol 154:387-97. 2011
    ..Iron burden was substantially reduced with appropriate dosing in patients treated for at least 4 years...
  99. ncbi Role of eosinophils in inflammatory bowel and gastrointestinal diseases
    Samantha A Woodruff
    Digestive Health Institute, The Children s Hospital, Denver, CO, USA
    J Pediatr Gastroenterol Nutr 52:650-61. 2011
    ..Although studies from the gut and other mucosal organs suggest eosinophils affect mucosal GI inflammation, definitive roles for eosinophils in IBDs await discovery...
  100. ncbi The impact of post-infectious functional gastrointestinal disorders and symptoms on the health-related quality of life of US military personnel returning from deployment to the Middle East
    Kashyap H Trivedi
    Division of Gastroenterology, University of California, Irvine, Orange, CA, USA
    Dig Dis Sci 56:3602-9. 2011
    ..Our aim was to evaluate the risk of PI-FGID and its impact on HRQOL among military personnel returning from deployment...
  101. ncbi Postinfectious functional gastrointestinal disorders
    Fermin Mearin
    Institute of Functional and Motor Digestive Disorders Centro Médico Teknon, Barcelona, Spain
    J Clin Gastroenterol 45:S102-5. 2011
    ....

Research Grants64

  1. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..new targets for future therapeutic approaches for the treatment of several common stress-associated gastrointestinal diseases. This proposal will establish a new Collaborative Research Program by bringing together complementary ..
  2. Myosin phosphatase autoinhibition in gastrointestinal smooth muscle contraction
    Avril V Somlyo; Fiscal Year: 2012
    ..provided by applicant): Alterations in the contractile state of smooth muscle (SM) plays a key role in gastrointestinal diseases such as gastric, intestinal and sphincter dysfunction, abnormal motility and other pathologies...
  3. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    ..On the other hand, acupuncture has been used extensively for treatment of various painful conditions and gastrointestinal diseases in Traditional Chinese Medicine...
  4. TAM receptor tyrosine kinases in inflammatory bowel disease
    Carla Rothlin; Fiscal Year: 2013
    ..1 million people in the US and represent two of the major gastrointestinal diseases of the Western world...
  5. Regulation of Apical-Basal Cell polarity during Intestinal Epithelial Morphogenes
    Nan Gao; Fiscal Year: 2013
    ..Several cell polarity genes have been implicated in gastrointestinal diseases, in particular the colon cancer. My recent work with Dr...
  6. Assessing the Impact of Osteogenesis Imperfecta on Non-Skeletal Systems
    Laura Tosi; Fiscal Year: 2012
    ..of OI on major health questions, such as the appropriate treatment of cardiovascular disease, gastrointestinal diseases, and cancers...
  7. PAF Receptor Trafficking and Function in Epithelial Cells
    Tamas Jilling; Fiscal Year: 2010
    Platelet-activating factor (PAF) has been implicated as a key mediator in the pathogenesis of gastrointestinal diseases such as Crohn's disease, ulcerative colitis and neonatal necrotizing enterocolitis (NEC)...
  8. Sex-specific genetic architecture of irritable bowel syndrome
    Lisa A Kilpatrick; Fiscal Year: 2013
    ..Such differences have important implications for tailoring treatments to individuals and are expected to stimulate the field of personalized medicine. ..
  9. Patient research in eosinophilic gastrointestinal diseases
    Glenn T Furuta; Fiscal Year: 2013
    ..of Medicine (CUSOM) for high impact POR and to nurture a pipeline of new investigators in Eosinophilic Gastrointestinal Diseases (EGIDs)...
  10. Regulation of esophageal gene expression and function by KLF5 and p53
    Jonathan P Katz; Fiscal Year: 2013
    ..is an expert in the Kr[unreadable]ppel-like factors (KLFs), transcriptional regulation, animal models of gastrointestinal diseases, and esophageal squamous cell biology, as demonstrated by recent, relevant corresponding-author ..
  11. X-RAY AND CHEMICAL STUDIES OF METALLOPORPHYRINS
    W Robert Scheidt; Fiscal Year: 2010
    ..of such signaling contributes to many disease states from neurodegeneration, stroke, hypertension, and gastrointestinal diseases to erectile dysfunction and heart disease...
  12. Mechanisms of gastrointestinal cell responses to Notch Signaling
    Tae Hee Kim; Fiscal Year: 2013
    ..my career and permit me to make a long-term commitment toward studying the unique biology that underlies gastrointestinal diseases. In the long-term future as a successful independent investigator, I will devote myself to understanding ..
  13. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
    Parenteral nutrition (PN) solutions are life saving in patients with surgical gastrointestinal diseases. However, the use of PN in pediatric populations, especially premature infants, is frequently associated with liver injury that may ..
  14. Novel Mechanisms of Visceral Pain: Functional Properties of Microglia
    Jennifer L Watts; Fiscal Year: 2012
    ..This research will potentially broaden treatment options available for IBD, which may also extend to treatment of functional gastrointestinal disorders like irritable bowel syndrome. ..
  15. Spinal glia activation in chronic stress-induced visceral hyperalgesia
    Sylvie Bradesi; Fiscal Year: 2013
    ....
  16. Developmental toxicity of bisphenol A and immune-mediated diseases
    B Paige Lawrence; Fiscal Year: 2010
    ..research team with expertise in toxicology, immunology, immune development, and pulmonary and gastrointestinal diseases. In the 1st Aim a determination of how developmental exposure to BPA affects the development of the ..
  17. Dissecting stromal-epithelial interactions in the adult exocrine pancreas
    Andrew D Rhim; Fiscal Year: 2013
    ..is renowned for his work in the application of developmental principles to the understanding of gastrointestinal diseases, including cancer...
  18. Central and Peripheral Autonomic Responses in Irritable Bowel Syndrome
    Kirsten Tillisch; Fiscal Year: 2010
    ..The proposed training will provide the candidate with a novel set of skills to use in investigating the potential causes of IBS, and developing new treatment strategies. ..
  19. UBIQUITIN AND CELLULAR FACTORS IN CORONAVIRUS ASSEMBLY
    THOMAS MILLER GALLAGHER; Fiscal Year: 2010
    Coronaviruses cause respiratory and gastrointestinal diseases in birds and animals. These RNA viruses are genetically variable and can rapidly evolve to infect humans, sometimes causing severe acute respiratory disease...
  20. Phase I: Safety and Tolerance of Lactobactocillus reuteri in Adults
    Jon Marc Rhoads; Fiscal Year: 2011
    ..We also hope to conduct future research on probiotic therapeutic interventions in gastrointestinal diseases. Much more information is needed to characterize the complex gut microflora-immune system in association ..
  21. RESEARCH TRAINING PROGRAM IN GASTROENTEROLOGY
    Jack R Wands; Fiscal Year: 2013
    ..interactions, and the implementation of basic research approaches for the diagnosis and prevention of gastrointestinal diseases. The training program is committed to offering opportunities to minority pre- and postdoctoral trainees, ..
  22. Surgical Research Training in Gastrointestinal Diseases
    Mark R Hellmich; Fiscal Year: 2013
    ..The research interests of our faculty members all center on the theme of gastrointestinal diseases, including the liver and pancreas, with a predominance on the study of cancer and inflammation...
  23. Pathways to New Biomarkers in Recurrent Abdominal Pain in Children
    Robert Shulman; Fiscal Year: 2013
    ..The results of this proposal will provide insight into the factors responsible for abdominal pain symptoms to allow better patient-specific treatment. ..
  24. Time-resolved measurements of breath hydrogen sulfide
    STEVEN M MASSICK; Fiscal Year: 2010
    ..focuses on detection of hydrogen sulfide in breath as a way of monitoring and developing treatments for debilitating gastrointestinal diseases such as irritable bowel syndrome, inflammatory bowel disease and Crohn's disease.
  25. METAGENOMIC ENGINEERING OF PROBIOTIC BACTERIA TO IMPROVE INTESTINAL COLONIZATION
    Gautam Dantas; Fiscal Year: 2012
    ..established microbiota, with the potential for rapid therapeutic deployment for the treatment of human gastrointestinal diseases. Public Health Relevance: Modulation of the human gastrointestinal microbiota through probiotic therapy ..
  26. TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGY
    SCOTT LAURENCE FRIEDMAN; Fiscal Year: 2013
    ..Development &Stem cells;or E) Patient-oriented Clinical Investigation in Hepatobililary and Gastrointestinal Diseases. The training will provide a solid foundation for future success in investigative Gastroenterology...
  27. RESEARCH TRAINING IN GASTROINTESTINAL RESEARCH
    HOBART WHITAKER HARRIS; Fiscal Year: 2013
    ..Therefore, it is essential that surgeons are trained in gastrointestinal research to prepare them for careers as surgeon-scientists investigating the causes and treatments for gastrointestinal diseases.
  28. Otubain 1 as a novel regulator of IL-15 signaling in CD8+ T cells
    ALBERT CHUH KAI LEE; Fiscal Year: 2013
    ..By working on a project that uses a wide-array of tools in the context of fundamental inflammatory gastrointestinal diseases, he will acquire first-rate scientific skills and acumen guided by clinically important questions...
  29. Colonoscopy quality and outcomes in clinical practice
    Cynthia W Ko; Fiscal Year: 2010
    ..is recommended for colorectal cancer screening as well as the diagnosis and treatment of various gastrointestinal diseases. It is one of the most common ambulatory care procedures, with estimates of over 14 million procedures ..
  30. Beta-Catenin/NF-kB in Hyperplasia/Neoplasia of Colonic Crypts: Chemoprevention
    Shahid Umar; Fiscal Year: 2011
    ..varying degrees of inflammation occur with pathophysiological similarities to human inflammatory gastrointestinal diseases. In Swiss-Webster outbred mice, TMCH is associated with increases in 2-catenin and its downstream ..
  31. Enteric CRF Receptor Signaling in Stress-Induced Intestinal Barrier Dysfunction
    Adam Moeser; Fiscal Year: 2013
    ..Stress-induced intestinal disorders such as Irritable Bowel Syndrome are the most economically burdensome gastrointestinal diseases known...
  32. Nanoparticle-Hydrogel Strips for Detection of Staphylococcal Enterotoxins
    Chuanmin Ruan; Fiscal Year: 2009
    ..B (SEB) in food products is a crucial step to ensure food safety and prevent food intoxication and gastrointestinal diseases. Current SEB detection is enzyme-linked immunosorbent assay (ELISA), reverse phase latex agglutination ..
  33. Mast Cell-Mediated Intestinal Permeability
    Katherine Groschwitz; Fiscal Year: 2010
    ..of therapeutic strategies for the prevention and treatment of food allergies and possibly other gastrointestinal diseases. Relevance: This grant application will investigate the mechanisms regulating intestinal permeability, ..
  34. Gastrointestinal Diseases Training Grant
    HUGO RAMON ROSEN; Fiscal Year: 2013
    ..The cutting-edge and collaborative research environment this project provides for young investigators is key to finding future clinical solutions for these public health concerns. ..
  35. Novel minimally invasive assessment of gastrointestinal inflammation in food alle
    Glenn Furuta; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE) Food allergic diseases (including eosinophilic gastrointestinal diseases such as eosinophilic esophagitis) currently afflict an estimated 4-6% of the United States population...
  36. FASEB SRC on Nutritional Immunology: Its effects on health and disease.
    Melinda A Beck; Fiscal Year: 2011
    ..can play a role in altering the immune function in diseases such as obesity, neurodegeneration, asthma, gastrointestinal diseases and infectious disease...
  37. X-ray diffraction analysis of human adenoviruses
    Vijay S Reddy; Fiscal Year: 2013
    ..provided by applicant): Adenoviruses (Ad) are major causative agents of respiratory, ocular and gastrointestinal diseases. Replication-defective and conditionally replicating Ad vectors are also being employed in a significant ..
  38. FASEB SRC on Probiotics, Intestinal Microbiota and the Host: Physiological and Cl
    W Allan Walker; Fiscal Year: 2011
    ..and gut microbiota in metabolism/obesity, prevention of allergy and common infectious diseases, gastrointestinal diseases, and functioning genomics. Safety, technical and regulatory issues will also be addressed...
  39. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Although essential, the use of parenteral nutrition (PN) in pediatric populations with surgical gastrointestinal diseases, especially premature infants, is frequently associated with hepatic dysfunction that may ultimately ..
  40. Isolation and Characterization of Intestinal Stem Cells Using Novel Markers (RP)
    COURTNEY WAYNE HOUCHEN; Fiscal Year: 2013
    ..These studies should help in the development of novel regenerative medicine strategies to treat inflammatory gastrointestinal diseases, and perhaps in targeting the stem cell in gut neoplasia.
  41. ABSORPTION, SECRETION, MALABSORPTION AND DIARRHEA
    JOHN FORDTRAN; Fiscal Year: 2002
    ..fat and protein malabsorption; 7) to determine the physical factors which control fecal consistency; and 8) to determine the mechanisms by which gastrointestinal diseases result in disorders of acid-base balance and potassium depletion.
  42. Patient Oriented Research in Pediatric Motility and Related Disorders
    Samuel Nurko; Fiscal Year: 2013
    ..Throughout their training years trainees will be prepared for academic careers. The K24 award will provide with essential support for the applicant to achieve his mentorship and research goals. ..
  43. Abdominal Symptom Phenotypes: Pathways to New Biomarkers
    Robert Shulman; Fiscal Year: 2010
    ..New biomarkers (video capsule endoscopy, lymphocyte activation/cytokine diffuse noxious inhibitory control testing) will be used with newly recruited IBS and control subjects. ..
  44. Function and Regulatin of Intestinal Basolateral Organic Solute Transporters
    Anuradha Rao; Fiscal Year: 2009
    ..in intestinal defense, it will be important to determine the specific functions of transporters such as Osta-Ostp and Mrp3 and if loss of these transporters contributes to the development or progression of gastrointestinal diseases.
  45. MUCOSAL PROTECTIVE FACTORS IN HUMAN MILK
    Radhakrishna Rao; Fiscal Year: 2003
    ..mucosa, and to determine the role of milk-borne mucosal protective factors in preventing neonatal gastrointestinal diseases, such as NEC...
  46. GDNF in the Enteric Nervous System
    Yun Xia; Fiscal Year: 2007
    ..abstract_text> ..
  47. GASTROENTEROLOGY RESEARCH TRAINING
    Ryan B Sartor; Fiscal Year: 2013
    ..A diverse, extensive training program helps our trainees develop new insights into the pathogenesis of gastrointestinal diseases and perform basic and translational research to identify novel diagnostic and treatment approaches...
  48. INTESTINAL PEPTIDE HYDROLASES AND PEPTIDE TRANSPORT
    Young Kim; Fiscal Year: 2000
    ..a better understanding of the biochemical and physiological alterations that are responsible for various gastrointestinal diseases. The gene promoter of one of these enzymes, DPPIV, will be characterized and mapped in detail...
  49. Genetic and Environmental Influences on Childhood Growth
    Bradford Towne; Fiscal Year: 2006
    ..done by establishing a longitudinal study of a large cohort of children in rural Nepal where parasitic gastrointestinal diseases are endemic...
  50. Physiologic membrane traffic regulation: intestinal CFTR
    Nadia Ameen; Fiscal Year: 2006
    This proposal addresses critical issues that will directly influence the treatment of two important gastrointestinal diseases: cystic fibrosis (CF) and secretory diarrhea...
  51. FIBROBLAST GROWTH FACTORS IN INFLAMMATORY BOWEL DISEASE
    Steven Cohn; Fiscal Year: 2002
    ..of functional and morphological gut differentiation and is a characteristic pathological feature of many gastrointestinal diseases including inflammatory bowel disease...
  52. Paracrine Regulation of IGF-I in the Developing Ileum
    Phillip Gordon; Fiscal Year: 2006
    ..management of development-related bowel disease but also to contribute to the global understanding of gastrointestinal diseases that manifest aberrant tissue growth...
  53. MECHANISMS AND MODULATION OF VISCERAL PAIN
    Gerald Gebhart; Fiscal Year: 2009
    ..g., ATP, mast cell tryptase, serotonin) contribute to visceral hypersensitivity and can do so in the absence of frank tissue damage, which is relevant to IBS and other functional gastrointestinal disorders. ..
  54. IDENT OF H PYLORI VIRUL FACTORS IN ETHNIC POPULATIONS
    David Graham; Fiscal Year: 2000
    ..have also been identified and they may be differentially present or expressed in different Hp-related gastrointestinal diseases. Our primary hypothesis is that different disease manifestations of Hp infection in different ethnic ..
  55. REGULATION OF CALCIUM RELEASE IN INTESTINAL MYOCYTES
    Klaus Bielefeldt; Fiscal Year: 2002
    ..Changes in the calcium homeostasis of smooth muscle cells may thus contribute to common gastrointestinal diseases, such as constipation, diarrhea, or gastroesophageal reflux disease...
  56. INRSA Training Grant in Gastroenterology
    AVERIL I MA; Fiscal Year: 2013
    ..biology, microbiology and epidemiology have had major impacts on the understanding of pathophysiology of gastrointestinal diseases. The UCSF Division of Gastroenterology has been a leader in gastrointestinal research for over 40 years...
  57. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..and defense against dietary toxins and antigens, and it has been more and more implicated in a number of gastrointestinal diseases. Although the enteric nervous system can act autonomously for local control, its integrative functions ..
  58. Research Symposium on Functional Abdoninal Pain in Children
    Samuel Nurko; Fiscal Year: 2007
    ..7. To educate the NASPGHAN membership on the state of the art of functional abdominal pain and IBS in children. [unreadable] [unreadable] [unreadable]..
  59. Gastroenteritis and Extreme Weather Events in Elderly
    Elena Naumova; Fiscal Year: 2006
    ..and Extreme Weather Events in Elderly (GEWEL)" is to examine how temporal and spatial patterns of gastrointestinal diseases (GID) respond to extreme weather events at the national and regional levels...
  60. MUCOSAL MAST CELLS AND INTESTINAL DISEASES
    Kim Barrett; Fiscal Year: 1992
    ..from intestinal tissue specimens of patients with inflammatory bowel disease, or other immune- related gastrointestinal diseases as available...
  61. Phenotypic Changes Underlying Visceral Hypersensitivity in a Mouse Model of IBs
    JULIE A CARLSTEN CHRISTIANSON; Fiscal Year: 2010
    ..S. In most gastrointestinal diseases, pain is often the first warning of organ dysfunction;however, in functional bowel disorders (FBD), like ..
  62. Treatment of Fear and Pain in Irritable Bowel Syndrome
    Bruce Naliboff; Fiscal Year: 2006
    ..abstract_text> ..
  63. ACTIVE POTASSIUM TRANSPORT ACROSS COLONIC EPITHELIUM
    DAN HALM; Fiscal Year: 2000
    ..of these regulatory cascades in the vacuolated columnar cells would form the basis of a variety of gastrointestinal diseases ranging from secretory diarrhea to inflammatory bowel disease...
  64. Breath Ammonia Method for H. pylori Detection
    David Putnam; Fiscal Year: 2003
    ..significance because the organism is the cause of most peptic ulcers and is associated with other gastrointestinal diseases including cancers...