pancreatic ductal carcinoma

Summary

Summary: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.

Top Publications

  1. ncbi Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas
    N Volkan Adsay
    Departments of Pathology, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
    Am J Surg Pathol 28:839-48. 2004
  2. pmc Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    Sian Jones
    Sol Goldman Pancreatic Cancer Research Center, Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1801-6. 2008
  3. ncbi A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform
    Bence Sipos
    Department of Pathology, University of Kiel, Germany
    Virchows Arch 442:444-52. 2003
  4. ncbi New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy
    Akiko Nakamura
    Department of Pathology, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima, Japan
    J Pathol 197:201-10. 2002
  5. ncbi Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma
    Koichi Inami
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Oncol Rep 20:1375-80. 2008
  6. pmc Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
    Meritxell Gironella
    Institut National de Santé et de Recherche Médicale, U624 Stress Cellulaire, F 13288 Marseille, France
    Proc Natl Acad Sci U S A 104:16170-5. 2007
  7. ncbi Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta
    Susanne Müerköster
    Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Medicine, UKSH Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Cancer Res 64:1331-7. 2004
  8. ncbi Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis
    Hong Cheng Sun
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai 200080, PR China
    Int J Oncol 30:1359-67. 2007
  9. pmc PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas
    Frank Schönleben
    Department of Otolaryngology Head and Neck Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Cancer Res 12:3851-5. 2006
  10. ncbi Pancreatic resection for M1 pancreatic ductal adenocarcinoma
    Shailesh V Shrikhande
    Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai, 400012, India
    Ann Surg Oncol 14:118-27. 2007

Detail Information

Publications246 found, 100 shown here

  1. ncbi Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas
    N Volkan Adsay
    Departments of Pathology, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
    Am J Surg Pathol 28:839-48. 2004
    ....
  2. pmc Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    Sian Jones
    Sol Goldman Pancreatic Cancer Research Center, Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1801-6. 2008
    ..Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis...
  3. ncbi A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform
    Bence Sipos
    Department of Pathology, University of Kiel, Germany
    Virchows Arch 442:444-52. 2003
    There are a large number of stable pancreatic ductal carcinoma cell lines that are used by researchers worldwide. Detailed data about their differentiation status and growth features are, however, often lacking...
  4. ncbi New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy
    Akiko Nakamura
    Department of Pathology, Kagoshima University Faculty of Medicine, Sakuragaoka, Kagoshima, Japan
    J Pathol 197:201-10. 2002
    ..In conclusion, our classification of IPMTs by MUC2 expression pattern may be of value in the better assessment of the biological behaviour of IPMTs and their potential for malignancy...
  5. ncbi Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma
    Koichi Inami
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Oncol Rep 20:1375-80. 2008
    ..b>Pancreatic ductal carcinoma remains a fatal disease because its diagnosis often occurs very late...
  6. pmc Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
    Meritxell Gironella
    Institut National de Santé et de Recherche Médicale, U624 Stress Cellulaire, F 13288 Marseille, France
    Proc Natl Acad Sci U S A 104:16170-5. 2007
    ..Finally, TP53INP1 expression is repressed by the oncogenic micro RNA miR-155, which is overexpressed in PDAC cells. TP53INP1 is a previously unknown miR-155 target presenting anti-tumoral activity...
  7. ncbi Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta
    Susanne Müerköster
    Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Medicine, UKSH Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Cancer Res 64:1331-7. 2004
    b>Pancreatic ductal carcinoma is characterized by a profound chemoresistance. As we have shown previously, these tumor cells can develop chemoresistance by interleukin (IL)-1beta in an autocrine and nuclear factor-kappaB-dependent fashion...
  8. ncbi Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis
    Hong Cheng Sun
    Department of General Surgery, Affiliated First People s Hospital, Shanghai Jiao Tong University, Shanghai 200080, PR China
    Int J Oncol 30:1359-67. 2007
    ..These results suggest that over-expression of HIF-1alpha may play an important role in cancer progression through up-regulation of VEGF and Glut-1 in PDA patients. HIF-1alpha and VEGF are potential candidates for predicting survival...
  9. pmc PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas
    Frank Schönleben
    Department of Otolaryngology Head and Neck Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Cancer Res 12:3851-5. 2006
    ..The mutational status of PIK3CA in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) has not been evaluated previously...
  10. ncbi Pancreatic resection for M1 pancreatic ductal adenocarcinoma
    Shailesh V Shrikhande
    Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai, 400012, India
    Ann Surg Oncol 14:118-27. 2007
    ..Improved safety of pancreatic surgery has led to consideration of more aggressive approaches, such as resection for primary pancreatic ductal adenocarcinoma (PDAC) with metastatic disease (M1)...
  11. ncbi Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma
    P Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Cancer Res 61:4320-4. 2001
    ..PSCA is a novel tumor marker for pancreatic carcinoma that has potential diagnostic and therapeutic implications. These results establish the validity of analyses of SAGE databases to identify novel tumor markers...
  12. pmc HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma
    Alexandra C Hristov
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mod Pathol 22:43-9. 2009
    ..Our results support a role for HMGA2 in the progression of pancreatic ductal adenocarcinoma and suggest that it could be a useful biomarker and rational therapeutic target in more advanced disease...
  13. ncbi The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
    Mert Erkan
    Department of General Surgery, Technische Universitat Munchen, Munich, Germany
    Clin Gastroenterol Hepatol 6:1155-61. 2008
    ..Pancreatic stellate cells (PSCs) produce this excessively desmoplastic microenvironment. The impact of PSC activity on PDAC behavior in vivo is analyzed...
  14. ncbi Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    Max G Bachem
    Department of Clinical Chemistry, University of Ulm, D 89070 Ulm, Germany
    Gastroenterology 128:907-21. 2005
    ..The aims of this study were to examine the cellular and molecular mechanisms of fibrogenesis associated with pancreatic adenocarcinomas...
  15. ncbi Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN
    Jens T Siveke
    Department of Internal Medicine, Technical University of Munich, D 81675 Munich, Germany
    Cancer Cell 12:266-79. 2007
    ..In conclusion, Egfr signaling in synergy with oncogenic Kras may be a prerequisite for IPMN development and progression to pancreatic cancer...
  16. ncbi Precursors to invasive pancreatic cancer
    Anirban Maitra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Adv Anat Pathol 12:81-91. 2005
    ..Finally, the potential clinical impact of recognizing these precursor lesions in the context of early detection of pancreatic cancer will be discussed...
  17. ncbi Molecular pathogenesis of pancreatic cancer
    Anirban Maitra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Best Pract Res Clin Gastroenterol 20:211-26. 2006
    ..This chapter will provide an overview of the molecular pathogenesis of pancreatic cancer with emphasis on clinical applications...
  18. ncbi Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment
    Pascal O Berberat
    Division of Pancreatic Surgery and Molecular Pancreatic Research, Department of General Surgery, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 11:3790-8. 2005
    ..Therefore, specific inhibition of HO-1 expression may be a new option in pancreatic cancer therapy and may be used as sensitizer to chemotherapy and radiotherapy...
  19. pmc High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF
    Andreas Claudius Hoffmann
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Neoplasia 10:674-9. 2008
    ..In this study, we investigated the prognostic values of HIF1a, bFGF, VEGF, and PDGFA gene expressions as well as their interrelationships...
  20. pmc Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    Jean Paul De La O
    Department of Human Genetics, University of Utah, 15 North 2030 East, Room 2100, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 105:18907-12. 2008
    ..At the cellular level, Notch/Kras coactivation promotes rapid reprogramming of acinar cells to a duct-like phenotype, providing an explanation for how a characteristically ductal tumor can arise from nonductal acinar cells...
  21. ncbi Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas
    J K Pine
    St James s University Hospital, Leeds, UK
    Eur J Surg Oncol 35:605-10. 2009
    ..We sought to determine the prognostic importance of serum CRP prior to biliary intervention in the prognosis of pancreatic adenocarcinoma...
  22. pmc Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis
    Matthias Lohr
    Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    Neoplasia 7:17-23. 2005
    ....
  23. ncbi Correlations between p53 gene mutations and histologic characteristics of pancreatic ductal carcinoma
    Atsuko Taii
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pancreas 38:e60-7. 2009
    ....
  24. pmc Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
    Hideaki Ijichi
    Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Genes Dev 20:3147-60. 2006
    ..The data show that blockade of TGF-beta signaling and activated Ras signaling cooperate to promote PDAC progression...
  25. ncbi Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells
    Madoka Ishikawa
    Division of Functional Genomics, Jichi Medical School, Kawachi gun, Tochigi, Japan
    Cancer Sci 96:387-93. 2005
    b>Pancreatic ductal carcinoma (PDC) remains one of the most intractable human malignancies, mainly because of the lack of sensitive detection methods...
  26. pmc Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis
    P S Moore
    Department of Pathology, , Italy
    Br J Cancer 84:253-62. 2001
    ..These data suggest that pancreatic exocrine and endocrine tumourigenesis involves different genetic targets and that among exocrine pancreatic neoplasms, only ductal and ampullary cancers share common molecular events...
  27. pmc Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma
    Noriyoshi Fukushima
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:1573-81. 2002
    ....
  28. ncbi Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas
    Hany Kayed
    Department of General Surgery, The University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Mol Carcinog 42:183-92. 2005
    ....
  29. ncbi Outcomes following resection of invasive and noninvasive intraductal papillary mucinous neoplasms of the pancreas
    Keita Wada
    Department of General Surgery, Virginia Mason Medical Center, 1100 Ninth Ave, C6 Gsurg, Seattle, WA 98111, USA
    Am J Surg 189:632-6; discussion 637. 2005
    ..Since any intraductal papillary mucinous neoplasm (IPMN) is at least premalignant, avoiding conversion to invasion by pancreatic resection should provide a survival advantage-but how much?..
  30. ncbi Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience
    Axel Richter
    Department of Surgery, University Hospital Mannheim, University of Heidelberg, Theodor Kutzer Ufer, 68167, Mannheim, Germany
    World J Surg 27:324-9. 2003
    ..We concluded that surgical treatment is "as good as it gets," as extended techniques have not proved to produce better results...
  31. ncbi Stromal biology of pancreatic cancer
    Gerald C Chu
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Cell Biochem 101:887-907. 2007
    ..Such knowledge may be used to understand the evolution and biology of this lethal cancer and may convert these insights into new points of therapeutic intervention...
  32. ncbi Expression of Ezrin and phosphorylated Ezrin (pEzrin) in pancreatic ductal adenocarcinoma
    Yazhou Cui
    Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Key Laboratory of Ministry of Health for Biotech Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Jinan, China
    Cancer Invest 28:242-7. 2010
    ..pEzrin(- Tyr353) may be a potent prognosis predictor for pancreatic cancer...
  33. pmc The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
    CATHERINE CARRIERE
    Department of Medicine, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Hanover, NH 03756, USA
    Proc Natl Acad Sci U S A 104:4437-42. 2007
    ..Thus, the Nestin cell lineage is highly responsive to Kras oncogenic activation and may represent the elusive progenitor population in which PDAC arises...
  34. ncbi Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice
    Paul J Grippo
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 53706, USA
    Cancer Res 63:2016-9. 2003
    ..Our findings suggest that Kras mutation is associated with development of early stage duct-like lesions in pancreas, but that additional alterations must accompany progression to malignancy...
  35. ncbi The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Am J Surg Pathol 25:942-8. 2001
    ..The second group seems to be related to ductal carcinoma because of its MUC1 positivity in the absence or very weak MUC2 staining. The third group shows focal MUC1/MUC2 expression and is characterized by oncocytic histology...
  36. ncbi Expression of hypoxia-inducible factors is correlated with the presence of a fibrotic focus and angiogenesis in pancreatic ductal adenocarcinomas
    A Couvelard
    Department of Pathology, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    Histopathology 46:668-76. 2005
    ..To study the expression of hypoxia-regulated markers in pancreatic ductal adenocarcinomas (PA) in relationship to the presence of a fibrotic focus, angiogenesis quantification and clinical outcome...
  37. ncbi Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma
    Aleodor Andea
    Department of Pathology, Harper Hospital, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mod Pathol 16:996-1006. 2003
    ..The relatively high absolute occurrence of pancreatic intraepithelial neoplasia Grade 1A (mucinous duct lesions) in benign conditions (43%) suggests that this group represents a combination of neoplastic and non-neoplastic lesions...
  38. ncbi Frequent activation of AKT2 kinase in human pancreatic carcinomas
    Deborah A Altomare
    Human Genetic Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Cell Biochem 87:470-6. 2002
    ..Overall, these data suggest that upstream perturbations of the PI3K/AKT pathway contribute to frequent activation of AKT2 in pancreatic cancer, which may contribute to the pathogenesis of this highly aggressive form of human malignancy...
  39. ncbi Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    Carmen Guerra
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, E 28029 Madrid, Spain
    Cancer Cell 11:291-302. 2007
    ..These observations suggest that, during adulthood, PDA stems from a combination of genetic (e.g., somatic K-Ras mutations) and nongenetic (e.g., tissue damage) events...
  40. pmc Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma
    A V Biankin
    Cancer Research Program, Garvan Institute of Medical Research, and Division of Surgery, St Vincent s Hospital, Darlinghurst, NSW 2010 Australia
    Gut 50:861-8. 2002
    ....
  41. ncbi An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
    Ralph H Hruban
    Department of Pathology, The Johns Hopkins Medical Institutions, 401 N Broadway, Weinberg 2242, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 28:977-87. 2004
    ..We present a consensus classification of the precursor lesions in the pancreatic ducts, PanINs and IPMNs...
  42. ncbi A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile
    Paolo Monti
    Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Virchows Arch 445:236-47. 2004
    There are a large number of stable pancreatic ductal carcinoma cell lines (PDCL) that are used by researchers worldwide...
  43. pmc Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
    Liqin Zhu
    Department of Biological Sciences and the Purdue Cancer Center, Purdue University, Hansen Life Sciences Research Building, West Lafayette, IN 47907 2064, USA
    Am J Pathol 171:263-73. 2007
    ..Identification of an acinar contribution to PanIN formation offers new directions for successful targeted therapeutic approaches to combat this disease...
  44. ncbi Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer
    Hiroshi Nakashima
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 66:7041-9. 2006
    ....
  45. ncbi MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration
    David C Chhieng
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249 6823, USA
    Cancer 99:365-71. 2003
    ..study was to examine the pattern of phenotypic expression of MUC1 and MUC2 in pancreatic lesions obtained by fine-needle aspiration biopsy (FNA) and to determine the utility of MUC1 and MUC2 as markers for pancreatic ductal carcinoma.
  46. ncbi Outcome after pancreaticoduodenectomy for cancer in elderly patients
    Radu Scurtu
    From the Centre de Chirurgie Viscérale et de Transplantation, Hopitaux Universitaires de Strasbourg, CHU Hautepierre, France
    J Gastrointest Surg 10:813-22. 2006
    ..In elderly patients, age does not seem to influence the postoperative outcome after pancreaticoduodenectomy with pancreato-gastrostomy...
  47. ncbi Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival
    Thomas Greither
    Clinic of Radiation Therapy, Martin Luther University, Halle, Wittenberg, Germany
    Int J Cancer 126:73-80. 2010
    ..Furthermore, the putative target genes for these microRNAs suggest a complex signaling network that can affect PDAC tumorigenesis and tumor progression...
  48. ncbi Targeting histone deacetylases in pancreatic ductal adenocarcinoma
    Gunter Schneider
    Technische Universitat Munchen, Klinikum rechts der Isar, II Medizinische Klinik, Munchen, Germany
    J Cell Mol Med 14:1255-63. 2010
    ..Translating these rational-based therapies into the clinic will finally increase our chance to establish an effective HDACI-containing combination therapy effective against PDAC...
  49. ncbi Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma
    Niccola Funel
    Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Surgical Pathology, Molecular and Ultrastructural Pathology, University of Pisa, Pisa, Italy
    Lab Invest 88:773-84. 2008
    ..The use of these ex vivo techniques for molecular analysis of tumors therefore appears to be of some value in implementing the clinical management of PDAC...
  50. ncbi p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis
    Christophe Rosty
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Surg Pathol 27:1495-501. 2003
    ..This alteration, common to pancreatic cancer-associated PanINs, may contribute to the predisposition of patients with chronic pancreatitis to develop pancreatic ductal adenocarcinoma...
  51. ncbi MUC4 expression increases progressively in pancreatic intraepithelial neoplasia
    Michael J Swartz
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Clin Pathol 117:791-6. 2002
    ..Our data help establish the patterns of MUC4 expression in neoplastic precursors in the pancreas and add further support to the progression model for pancreatic adenocarcinoma...
  52. ncbi Analysis of long-term survivors after surgical resection for pancreatic cancer
    Sung Sik Han
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    Pancreas 32:271-5. 2006
    ..The purpose of this study was to determine the outcome of surgical resection for pancreatic cancer and to characterize the clinicopathologic features of actual long-term survivors...
  53. ncbi Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Cancer Res 10:2846-50. 2004
    ..In addition, activated extracellular signal-regulated kinase 1 and 2 (ERK1/2) and the proliferation activity of tumor cells detected by Ki-67 immunohistochemistry were examined...
  54. ncbi Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines
    Ami Takeda
    Division of Organ Pathology, Department of Microbiology and Pathology, Graduate School of Medicine, Tottori University, Yonago, Japan
    Pancreas 28:353-8. 2004
    ..LY294002, a PI3K inhibitor, might inactivate Akt, consequently inhibiting cell proliferation in 3 human pancreatic ductal carcinoma cell lines, PSN-1, PANC-1, and KP-4...
  55. ncbi Adjuvant therapy in pancreatic cancer: historical and current perspectives
    J P Neoptolemos
    Department of Surgery, University of Liverpool, Liverpool, UK
    Ann Oncol 14:675-92. 2003
    ....
  56. pmc Overexpression of HMGA1 promotes anoikis resistance and constitutive Akt activation in pancreatic adenocarcinoma cells
    S S Liau
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Br J Cancer 96:993-1000. 2007
    ..Given the putative associations between anoikis resistance and metastatic potential, HMGA1 represents a potential therapeutic target in pancreatic adenocarcinoma...
  57. ncbi Clinical management of intraductal papillary mucinous tumors of the pancreas based on imaging findings
    T Wakabayashi
    Department of Gastroenterology, Saiseikai Kanazawa Hospital, Japan
    Pancreas 22:370-7. 2001
    ....
  58. ncbi Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression
    Byungwoo Ryu
    Department of Oncology, 451 Cancer Research Building, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 62:819-26. 2002
    ..Others suggest potential novel therapeutic targets...
  59. ncbi Long-term surgical outcome of noninvasive and minimally invasive intraductal papillary mucinous adenocarcinoma of the pancreas
    Toshio Nakagohri
    Second Department of Surgery, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    World J Surg 26:1166-9. 2002
    ..The remaining 13 patients are alive and disease free 3 to 12 years after surgery. Noninvasive and minimally invasive intraductal papillary mucinous adenocarcinoma had a favorable prognosis after surgical treatment...
  60. ncbi Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions
    Benoit Terris
    Services d anatomie pathologique, Hopital Cochin, Paris, France
    J Pathol 197:632-7. 2002
    ....
  61. pmc Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma
    F Maire
    Fédération Médico Chirugicale d Hépato Gastroentérologie, Hopital Beaujon, Clichy, France
    Gut 51:717-22. 2002
    ..Although the prognosis in malignant resectable intraductal papillary mucinous tumours of the pancreas (IPMT) is often considered more favourable than for ordinary pancreatic ductal adenocarcinoma, the long term outcome remains ill defined...
  62. ncbi Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas
    Norihiro Sato
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Gastroenterology 123:365-72. 2002
    ..We hypothesized that an alternative mechanism for gene inactivation (notably, transcriptional silencing by promoter methylation) could be important in the pathogenesis of IPMNs...
  63. ncbi Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes
    Heike Immervoll
    Section for Pathology, The Gade Institute, University of Bergen, Haukeland University Hospital, Bergen N 5021, Norway
    Virchows Arch 448:788-96. 2006
    ..Apparently, these tumors depend on no more than one genetic hit in the EGFR-RAS-RAF signaling pathway...
  64. ncbi Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma
    Kosuke Tobita
    Department of Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Int J Oncol 21:1189-95. 2002
    ..These observations suggested that TSP-1 plays important roles in cancer cell growth and metastasis of human pancreatic cancer, and that stromal TSP-1 immunoreactivity is a good prognostic predictor of patients with pancreatic cancer...
  65. ncbi Is the intraductal papillary mucinous neoplasia of the biliary tract a counterpart of pancreatic papillary mucinous neoplasm?
    Gunter Kloppel
    J Hepatol 44:249-50. 2006
  66. ncbi Expression of transcription factor E2F-1 in pancreatic ductal carcinoma: an immunohistochemical study
    Kazuto Yamazaki
    Department of Pathology, Teikyo University, Ichihara Hospital, Ichihara, Chiba, Japan
    Pathol Res Pract 199:23-8. 2003
    ..015). The present analysis seems to support the theory that E2F-1 is upregulated in cell cycle, and its expression reflects the effector function of G1/S progression as far as pancreatic ductal carcinoma is concerned.
  67. ncbi Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study
    Toru Furukawa
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryomachi, Sendai, 980 8575, Japan
    Virchows Arch 447:794-9. 2005
    ..These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN...
  68. ncbi Effects of bone sialoprotein on pancreatic cancer cell growth, invasion and metastasis
    Hany Kayed
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Cancer Lett 245:171-83. 2007
    ....
  69. ncbi The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: insights for clinicians
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Curr Gastroenterol Rep 6:111-8. 2004
    ..Molecular studies have revealed that PanIN-2 and PanIN-3 lesions represent a distinct step toward invasive carcinoma...
  70. ncbi Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4
    P S Moore
    Department of Pathology, University of Verona, Italy
    Virchows Arch 439:798-802. 2001
    The K-ras, p53, p16 and DPC4 genes are among those most frequently altered in pancreatic ductal carcinoma. We analyzed 22 cell lines for alterations in these genes by direct sequence analysis and methylation-specific polymerase chain ..
  71. ncbi Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry
    Jianjun Shen
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas, USA
    Cancer Res 64:9018-26. 2004
    ..The newly identified proteins in pancreatic tumors may eventually serve as diagnostic markers or therapeutic targets...
  72. pmc Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    Andrew J Aguirre
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 17:3112-26. 2003
    ..This faithful mouse model may permit the systematic analysis of genetic lesions implicated in the human disease and serve as a platform for the identification of early disease markers and for the efficient testing of novel therapies...
  73. ncbi Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma
    Carolin Reiser-Erkan
    Department of Surgery, Technische Universitat Munchen, Munich, Germany
    Cancer Biol Ther 7:1352-9. 2008
    ..Clinically, absence of Pim-1 expression correlates with poor prognosis in prostate cancer. In the present study, the expression of Pim-1 is analyzed in pancreatic cancer and correlated to clinicopathological parameters...
  74. ncbi Evaluation of blood flow in pancreatic ductal carcinoma using contrast-enhanced, wide-band Doppler ultrasonography: correlation with tumor characteristics and vascular endothelial growth factor
    Tadashi Ohshima
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Pancreas 28:335-43. 2004
    ..However, there have been only a few reports on tumor vascularization in pancreatic ductal carcinoma, especially on vascularization depicted by imaging modalities...
  75. ncbi Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment
    Philip A Philip
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    J Clin Oncol 27:5660-9. 2009
    ..Patients with either metastatic or locally advanced PDAC must be studied separately...
  76. pmc GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
    Olivier Nolan-Stevaux
    Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 23:24-36. 2009
    ....
  77. ncbi Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma
    Meike Vogler
    University Children s Hospital, Ulm University, Ulm, Germany
    Cancer Res 69:2425-34. 2009
    ..These findings build the rationale for further (pre)clinical development of XIAP inhibitors and TRAIL against pancreatic cancer...
  78. pmc Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma
    Jyotika Attri
    Department of General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    BMC Gastroenterol 5:22. 2005
    ..The purpose of the study was to evaluate primary pancreatic ductal adenocarcinomas for potentially inactivating p16 alterations...
  79. ncbi Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
    Kamel Izeradjene
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Cell 11:229-43. 2007
    ..Our findings suggest that the sequence, as well as the context, in which these critical mutations are acquired helps determine the ensuing pathology...
  80. ncbi Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology
    Liying Han
    Department of Pathology, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan, USA
    Diagn Cytopathol 38:333-6. 2010
    ..It appears that the combination of MUC5ac and WT-1 stains is useful in distinguishing pancreatic ductal from ovarian serous carcinoma in body fluid cytology...
  81. ncbi Proteomic analysis of pancreatic ductal carcinoma cells after combined treatment with gemcitabine and trichostatin A
    Daniela Cecconi
    University of Verona, Department of Agricultural and Industrial Biotechnologies, Verona, Italy
    J Proteome Res 4:1909-16. 2005
    ..Our results demonstrate that the level of activation/repression of the proteins involved in these processes correlates with the growth inhibition and the apoptotic response of the cells subjected to single or combined drug treatment...
  82. ncbi Meta-analysis of microarray data on pancreatic cancer defines a set of commonly dysregulated genes
    Robert Grutzmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Oncogene 24:5079-88. 2005
    ..Meta-analysis is an important tool for the identification and validation of differentially expressed genes. These could represent good candidates for novel diagnostic and therapeutic approaches to pancreatic cancer...
  83. pmc Pancreatic carcinogenesis
    Jan Bart M Koorstra
    Department of Pathology, University Medical Center, Utrecht, The Netherlands
    Pancreatology 8:110-25. 2008
    ..This review focuses mainly on the current knowledge about the molecular insights of the pathogenesis of pancreatic ductal adenocarcinoma...
  84. ncbi Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
    Christine A Iacobuzio-Donahue
    Departments of Pathology, Surgery, Oncology, and Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 63:8614-22. 2003
    ....
  85. pmc Cannabinoids in pancreatic cancer: correlation with survival and pain
    Christoph W Michalski
    Department of General Surgery, Technische Universität Munich, Munich, Germany
    Int J Cancer 122:742-50. 2008
    ..Therefore, changes in the levels of endocannabinoid metabolizing enzymes and cannabinoid receptors on pancreatic cancer cells may affect prognosis and pain status of PDAC patients...
  86. pmc Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays
    Robert Grutzmann
    Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Neoplasia 6:611-22. 2004
    ..Within the panel of genes, we identified novel differentially expressed genes, which have not been associated with the pathogenesis of PDAC before...
  87. ncbi Expression of EGF and EGFR strongly correlates with metastasis of pancreatic ductal carcinoma
    Anna Pryczynicz
    Departments of General Pathomorphology, Medical University of Białystok, Białystok, Poland
    Anticancer Res 28:1399-404. 2008
    ..Recent reports have indicated that they are also involved in the growth of pancreatic ductal carcinoma, its invasiveness and metastasis.
  88. pmc Intraductal papillary mucinous neoplasms of the pancreas: an updated experience
    Taylor A Sohn
    Departments of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ann Surg 239:788-97; discussion 797-9. 2004
    ..To update the authors' experience with intraductal papillary mucinous neoplasms (IPMNs) of the pancreas...
  89. ncbi Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer
    Zofia Von Marschall
    Department of Hepatology, Gastroenterology, Endocrinology and Metabolism, Charite University Medicine Berlin, CVK, D 13353 Berlin, Germany
    Int J Oncol 27:669-79. 2005
    ..Our results suggest that VEGF-D plays a pivotal role in stimulating lymphangiogenesis and lymphatic metastasis in human ductal pancreatic cancer, and therefore represents a novel therapeutic target for this devastating disease...
  90. ncbi Possible detection of pancreatic cancer by plasma protein profiling
    Kazufumi Honda
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute 5 1 1 Tsukiji Chuoh ku, Tokyo, Japan
    Cancer Res 65:10613-22. 2005
    ..Although a multi-institutional large-scale study will be necessary to confirm clinical significance, the biomarker set identified in this study may be applicable to using plasma samples to diagnose pancreatic cancer...
  91. ncbi Do consensus indications for resection in branch duct intraductal papillary mucinous neoplasm predict malignancy? A study of 147 patients
    Mario Pelaez-Luna
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 102:1759-64. 2007
    ..Among a cohort of patients with IPMN-Br we determined if the consensus IR (CIR), presence of multifocal IPMN-Br, or growth of cyst size on follow-up predict malignancy...
  92. pmc Detecting early pancreatic cancer: problems and prospects
    Suresh T Chari
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Semin Oncol 34:284-94. 2007
    ..Although much work still needs to be done, the developments in the field provide us with hope that screening for early pancreatic cancer could become a reality in the not-so-distant future...
  93. pmc Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection
    Roberto Salvia
    Department of Surgery, University of Verona, Verona, Italy
    Ann Surg 239:678-85; discussion 685-7. 2004
    ..To describe clinical characteristics and outcomes of a large cohort of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas affecting the main pancreatic duct...
  94. ncbi 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience
    Jordan M Winter
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gastrointest Surg 10:1199-210; discussion 1210-1. 2006
    ..This is the largest single-institution experience with PD for pancreatic cancer. Patients who have cancers with favorable pathological features have a statistically significant improved long-term survival...
  95. ncbi Silencing of X-linked inhibitor of apoptosis (XIAP) decreases gemcitabine resistance of pancreatic cancer cells
    Shailesh V Shrikhande
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Anticancer Res 26:3265-73. 2006
    ..It confers resistance to apoptosis induction by chemotherapeutic agents. The aim of this study was to evaluate the influence of XIAP in pancreatic cancer...
  96. ncbi Clinicopathological significance of hypoxia-inducible factor-1alpha expression in human pancreatic carcinoma
    T Kitada
    Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Histopathology 43:550-5. 2003
    ..The aim of this study was to investigate the clinicopathological significance of HIF-1alpha expression in pancreatic carcinoma...
  97. ncbi Does contrast-enhanced ultrasound reveal tumor angiogenesis in pancreatic ductal carcinoma? A prospective study
    Mutsumi Nishida
    Radiation Oncology, Imaging and Diagnosis, Sapporo Medical University Graduate School of Medicine, Sapporo, Japan
    Ultrasound Med Biol 35:175-85. 2009
    ..Twenty-seven subjects with advanced pancreatic ductal carcinoma were treated by chemoradiotherapy...
  98. ncbi A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers
    L Charles Murtaugh
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Cancer Cell 11:211-3. 2007
    ..The results shed new light on the "cell of origin" of pancreatic ductal cancer and demonstrate that chronic pancreatitis provides a permissive environment for Kras-induced pancreatic neoplasia...
  99. pmc Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer
    H Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Br J Cancer 97:1106-15. 2007
    ..In addition, Runx2 has the potential to regulate the transcription of extracellular matrix modulators such as SPARC and MMP1, thereby influencing the tumour microenvironment...
  100. pmc Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model
    T H El-Metwally
    Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
    J Clin Pathol 59:603-10. 2006
    ..The pancreatic ductal adenocarcinoma (HPAF) cells have a multipotent stem cell potential. It was hypothesised that all-trans-retinoic acid (atRA) can induce transdifferentiation of these cells into cells with an endocrine phenotype...
  101. pmc Apoptotic pathways in pancreatic ductal adenocarcinoma
    Rainer Hamacher
    II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Mol Cancer 7:64. 2008
    ....

Research Grants38

  1. Proteasome-mediated Degradation of Hematopoietic Progenitor Kinase 1 in Pancreati
    Huamin Wang; Fiscal Year: 2012
    ..we demonstrated that HPK1 protein is expressed in normal pancreatic ducts, but is lost in >95% of pancreatic ductal carcinoma (PDC) samples...
  2. Prevention & Metastasis: Final Frontiers in Colon Cancer
    Robert Coffey; Fiscal Year: 2009
    ..Finally, we are continuing efforts to model pancreatic ductal carcinoma in the mouse...
  3. Small Molecule Antibody Mimics: Toward a New Paradigm in Targeted Cancer Therapy
    David A Spiegel; Fiscal Year: 2013
    ..both in prostate cancer cells and in tumor neovasculature for a wide variety of cancers (including pancreatic ductal carcinoma, colon adenocarcinoma, glioblastoma multiforme, and non-small cell lung carcinoma)...
  4. Inhibition of Prenylated Protein Processing
    Richard Gibbs; Fiscal Year: 2009
    ..cell permeable inhibitors will be evaluated for their ability to mislocalize Ras, interfere with Ras- mediated signaling, block anchorage-independent growth of pancreatic ductal carcinoma, and block tumor growth in vivo.
  5. Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)
    Christian Schmidt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2008
    ..Such information will be valuable for the primary prevention of this deadly disease. ..
  7. TARGETS OF METASTATIC PANCREATIC CANCER
    Christine Iacobuzio Donahue; Fiscal Year: 2008
    ..abstract_text> ..
  8. CLASSIFYING PANCREATIC CANCERS BY METHYLATOR PHENOTYPES
    Michael Goggins; Fiscal Year: 2006
    ..Aim #4: Determine if functional DNA methylation differences exist between CIMP+ compared to CIMP- pancreatic carcinomas. ..
  9. Does Hyperglycemia Predict Pancreatic Cancer Diagnosis?
    Suresh Chari; Fiscal Year: 2006
    ..The research described in this application is 100% relevant to pancreatic cancer. ..
  10. FOLATE PATHWAY POLYMORPHISMS AND PANCREATIC CANCER RISK
    Michael Goggins; Fiscal Year: 2002
    ..abstract_text> ..
  11. THE PanINs OF PANCREATITIS,PANCREAS CANCER AND CONTROLS
    Michael Goggins; Fiscal Year: 2002
    ..abstract_text> ..
  12. Markers of Early Pancreatic Cancer
    Michael G Goggins; Fiscal Year: 2010
    ..We will also determine the diagnostic utility of combining the results of the markers derived from these 3 Aims. ..
  13. Biomarkers of Heavy Metal Exposure Related to Pancreatic Cancer Genetic Mutations
    AMR SOLIMAN; Fiscal Year: 2007
    ..The results from this study will provide clues about the etiology of pancreatic cancer. [unreadable] [unreadable] [unreadable]..
  14. Role of ErbB/Stat3 in the establishment and progression of pancreatic cancer
    James Freeman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Mutant mouse models of exocrine pancreatic cancer
    DAVID TUVESON; Fiscal Year: 2008
    ..Information gained from this murine model should facilitate further understanding of human pancreatic cancer. ..
  16. The Role of CXCR2 in Pancreatic Cancer
    OSCAR HINES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Adult pancreatic progenitor cells as target of early oncogenic events
    CATHERINE CARRIERE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    William C Culp; Fiscal Year: 2010
    ..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..
  19. ENTERIC PHYSIOLOGY OF THE TRANSPLANTED GUT
    Michael Sarr; Fiscal Year: 2007
    ..This proposal will define important, novel neural mechanisms regulating motor and absorptive function in the denervated gut. Selected aspects have translational value to clinical gut transplantation. [unreadable] [unreadable]..
  20. REGULATION OF ESOPHAGEAL EPITHELIAL GENE EXPRESSION
    Anil Rustgi; Fiscal Year: 2001
    ..Three specific aims are proposed: (1) to isolate cDNA clones encoding KSF, (2) to characterize the tissue expression of KSF, and (3) to characterize the regulation of expression of the keratin 4 promoter by KSF. ..
  21. A flexible somatic and sporadic mouse model for pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2007
    ..Such an advance would benefit public health by reducing the mortality associated with this disease. [unreadable] [unreadable] [unreadable]..
  22. MoAbs for the Management of Pancreatic Cancer
    David Gold; Fiscal Year: 2005
    ..Finally, a PAM4IL2 fusion protein will be examined for its ability to enhance tumor uptake of a subsequently administered radiolabeled PAM4 antibody. ..
  23. A Sequencing Microarray for Mitochondrial Mutations
    Anirban Maitra; Fiscal Year: 2004
    ..This study will serve as a model for array-based diagnosis of cancer in clinical samples. ..
  24. Characterization of the Chromosome 17q23 Amplicon
    Fergus Couch; Fiscal Year: 2006
    ..Thus, the project may involve a complete transition from benchtop to bedside. Finally, the amplified and overexpressed genes may prove useful as important targets of gene, pharmacological, and immunological therapy in the future. ..
  25. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  26. Epidemiology of Colon Cancer in a Special Population
    AMR SOLIMAN; Fiscal Year: 2006
    ..Together, the training in these three areas will provide the skills and experience necessary for an independent career as a molecular and genetic epidemiologist interested in colorectal cancer. ..
  27. DPC4 function in human pancreatic cancer
    Gloria Su; Fiscal Year: 2006
    ..Su will be able to conduct her research in the richest intellectual and resourceful environment possible for academic and research career development. ..
  28. P21 INDUCTION BY BRCA2
    Fergus Couch; Fiscal Year: 2002
    ....
  29. Molecular Characterization of Inflammatory Breast Cancer
    AMR SOLIMAN; Fiscal Year: 2006
    ..With the large number of patients included in this study from Egypt and the U.S., we may be able develop a better idea about molecular pathways and prognostic factors in IBC pathogenesis. ..
  30. Hedgehog signaling in pancreatic neoplasia
    Anirban Maitra; Fiscal Year: 2006
    ..Specifically, it will be determined whether Hh misexpression can generate a phenotype of multistep progression of pancreatic cancer that resembles the cognate human condition. [unreadable] [unreadable]..
  31. Implications of Retinoid-Induced CD38 Antigen Expression
    Kapil Mehta; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  32. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..abstract_text> ..
  33. Role of MUC1 in Pancreatic Cancer
    Pinku Mukherjee; Fiscal Year: 2010
    ..This project is extremely relevant to pancreatic cancer. These preclinical studies will form the basis for designing more efficacious and novel therapies to combat the mortality associated with PDA. ..
  34. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2004
    ..Together these studies will provide important insights into the mechanisms regulating pancreatic acinar cell function. ..
  35. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2005
    ..2. To determine which products of the AA cascade are formed in untreated cells and in response to NNK, which of these products stimulate DNA synthesis, and what downstream effectors are activated by these products. ..
  36. THE INFLAMMATORY RESPONSE OF THE PANCREATIC ACINAR CELL
    Stephen Pandol; Fiscal Year: 2006
    ..The results of the experiments described in the present application will allow us to propose how CCK, together with a cytokine modulating its effects, acts on the pancreatic acinar cell to cause experimental pancreatitis. ..
  37. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2006
    ....
  38. Alcohol and the Exocrine Pancreas ER Stress Responses
    Stephen Pandol; Fiscal Year: 2007
    ..The results deriving from this project will allow us to pursue further projects on integrating the effects of ethanol on the UPR to the pathological responses of pancreatitis due to ethanol as well as provide. [unreadable] [unreadable]..