hepatocellular carcinoma

Summary

Summary: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

Top Publications

  1. ncbi Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    Hashem B El-Serag
    Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
    Gastroenterology 132:2557-76. 2007
  2. doi Sorafenib in advanced hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigaciones en Red de Enfermedades Hepáticas y Digestivas Hospital Clínic Barcelona, Barcelona
    N Engl J Med 359:378-90. 2008
  3. ncbi Molecular pathogenesis of human hepatocellular carcinoma
    Snorri S Thorgeirsson
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 31:339-46. 2002
  4. ncbi Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
    Y Murakami
    Laboratory of Human Tumor Virus, Institute for Viral Research, Kyoto University, Kyoto, Japan
    Oncogene 25:2537-45. 2006
  5. pmc Hepatocellular carcinoma: A global view
    Ju Dong Yang
    Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Nat Rev Gastroenterol Hepatol 7:448-58. 2010
  6. ncbi Rising incidence of hepatocellular carcinoma in the United States
    H B El-Serag
    Veterans Affairs Medical Center and the University of New Mexico, Albuquerque 87108, USA
    N Engl J Med 340:745-50. 1999
  7. ncbi Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    JAMA 295:65-73. 2006
  8. doi MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    F Fornari
    1Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Policlinico S Orsola, Bologna, Italy
    Oncogene 27:5651-61. 2008
  9. doi Design and endpoints of clinical trials in hepatocellular carcinoma
    Josep M Llovet
    HCC Translational Research Lab, Barcelona Clinic Liver Cancer Group, Liver Unit, Hospital Clinic, CIBERehd, Institute for Biomedical Investigations August Pi Sunyer, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    J Natl Cancer Inst 100:698-711. 2008
  10. pmc Molecular targeted therapies in hepatocellular carcinoma
    Josep M Llovet
    Mount Sinai Liver Cancer Program, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 48:1312-27. 2008

Detail Information

Publications347 found, 100 shown here

  1. ncbi Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    Hashem B El-Serag
    Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston, Texas, USA
    Gastroenterology 132:2557-76. 2007
    Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is the fifth most common cancer worldwide and the third most common cause of cancer mortality...
  2. doi Sorafenib in advanced hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigaciones en Red de Enfermedades Hepáticas y Digestivas Hospital Clínic Barcelona, Barcelona
    N Engl J Med 359:378-90. 2008
    No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived ..
  3. ncbi Molecular pathogenesis of human hepatocellular carcinoma
    Snorri S Thorgeirsson
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 31:339-46. 2002
    ..progressively alter the hepatocellular phenotype to produce cellular intermediates that evolve into hepatocellular carcinoma. During the long preneoplastic stage, in which the liver is often the site of chronic hepatitis, ..
  4. ncbi Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
    Y Murakami
    Laboratory of Human Tumor Virus, Institute for Viral Research, Kyoto University, Kyoto, Japan
    Oncogene 25:2537-45. 2006
    ..We analysed the miRNA expression profiles in 25 pairs of hepatocellular carcinoma (HCC) and adjacent non-tumorous tissue (NT) and nine additional chronic hepatitis (CH) specimens using a ..
  5. pmc Hepatocellular carcinoma: A global view
    Ju Dong Yang
    Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Nat Rev Gastroenterol Hepatol 7:448-58. 2010
    b>Hepatocellular carcinoma (HCC) is a global health problem, although developing countries are disproportionally affected: over 80% of HCCs occur in such regions. About three-quarters of HCCs are attributed to chronic HBV and HCV infections...
  6. ncbi Rising incidence of hepatocellular carcinoma in the United States
    H B El-Serag
    Veterans Affairs Medical Center and the University of New Mexico, Albuquerque 87108, USA
    N Engl J Med 340:745-50. 1999
    Clinical observations have suggested that the number of cases of hepatocellular carcinoma has increased in the United States...
  7. ncbi Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    JAMA 295:65-73. 2006
    ..Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B...
  8. doi MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    F Fornari
    1Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Policlinico S Orsola, Bologna, Italy
    Oncogene 27:5651-61. 2008
    ..MiR-221 is upregulated in human hepatocellular carcinoma (HCC) as well as in other malignancies...
  9. doi Design and endpoints of clinical trials in hepatocellular carcinoma
    Josep M Llovet
    HCC Translational Research Lab, Barcelona Clinic Liver Cancer Group, Liver Unit, Hospital Clinic, CIBERehd, Institute for Biomedical Investigations August Pi Sunyer, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    J Natl Cancer Inst 100:698-711. 2008
    The design of clinical trials in hepatocellular carcinoma (HCC) is complex because many patients have concurrent liver disease, which can confound the assessment of clinical benefit...
  10. pmc Molecular targeted therapies in hepatocellular carcinoma
    Josep M Llovet
    Mount Sinai Liver Cancer Program, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 48:1312-27. 2008
    b>Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with several genomic alterations...
  11. doi Modified RECIST (mRECIST) assessment for hepatocellular carcinoma
    Riccardo Lencioni
    Division of Diagnostic Imaging and Intervention, Department of Liver Transplantation, Hepatology, and Infectious Diseases, University of Pisa, Pisa, Italy
    Semin Liver Dis 30:52-60. 2010
    ..Measurement of response rate in hepatocellular carcinoma (HCC) has become a controversial issue...
  12. ncbi Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Liver Unit, Digestive Disease Institut, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Catalonia, Spain
    Hepatology 37:429-42. 2003
    There is no standard treatment for patients with unresectable hepatocellular carcinoma (HCC). Survival benefits derived from medical interventions are controversial...
  13. ncbi Management of hepatocellular carcinoma
    Jordi Bruix
    BCLC Group Liver Unit Hospital Clínic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Hepatology 42:1208-36. 2005
  14. doi Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
    Yujuan Xiong
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, China
    Hepatology 51:836-45. 2010
    Based on microarray data, we have previously shown a significant down-regulation of miR-29 in hepatocellular carcinoma (HCC) tissues...
  15. ncbi Hepatocellular carcinoma in cirrhosis: incidence and risk factors
    Giovanna Fattovich
    Department of Gastroenterology, University of Verona, Verona, Italy
    Gastroenterology 127:S35-50. 2004
    Emerging data indicate that the mortality rate of hepatocellular carcinoma (HCC) associated with cirrhosis is rising in some developed countries, whereas mortality from non-HCC complications of cirrhosis is decreasing or is stable...
  16. ncbi Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    Chung Mau Lo
    Center for the Study of Liver Disease, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    Hepatology 35:1164-71. 2002
    ..Laboratoire Guerbet, Aulnay-Sous-Bois, France) chemoembolization in patients with unresectable hepatocellular carcinoma. From March 1996 to October 1997, 80 out of 279 Asian patients with newly diagnosed unresectable ..
  17. doi Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
    Brad Q Starley
    Department of Medicine, Division of Gastroenterology and Hepatology, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
    Hepatology 51:1820-32. 2010
    b>Hepatocellular carcinoma (HCC) is a common and deadly malignancy that is increasing in incidence in developed countries...
  18. doi miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma
    Mayuko Furuta
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Carcinogenesis 31:766-76. 2010
    ..To identify such miRNAs in hepatocellular carcinoma (HCC), we first examined the methylation status of 43 loci containing CpG islands around 39 mature miRNA ..
  19. doi MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells
    Teng Xu
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Guangzhou, PR China
    Hepatology 50:113-21. 2009
    ..Our results showed that miR-195 expression was significantly reduced in as high as 85.7% of hepatocellular carcinoma (HCC) tissues and in all of the five HCC cell lines examined...
  20. ncbi Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Cancer Res 67:6092-9. 2007
    We investigated the role of microRNAs (miRNAs) in the pathogenesis of human hepatocellular carcinoma (HCC). A genome-wide miRNA microarray was used to identify differentially expressed miRNAs in HCCs arisen on cirrhotic livers...
  21. ncbi Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
    Elisa Wurmbach
    Mount Sinai Liver Cancer Program, Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 45:938-47. 2007
    ....
  22. doi Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    Ann Lii Cheng
    National Taiwan University Hospital, Taipei, Taiwan
    Lancet Oncol 10:25-34. 2009
    Most cases of hepatocellular carcinoma occur in the Asia-Pacific region, where chronic hepatitis B infection is an important aetiological factor...
  23. pmc Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    Sean F Altekruse
    Division of Cancer Control and Population Sciences, and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 8316, USA
    J Clin Oncol 27:1485-91. 2009
    b>Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Incidence rates are increasing in the United States...
  24. ncbi Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties
    Tetsuhiro Chiba
    Department of Regenerative Medicine, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan
    Hepatology 44:240-51. 2006
    ..In this study, we applied side population (SP) cell analysis and sorting to established hepatocellular carcinoma (HCC) cell lines to detect subpopulations that function as cancer stem cells and to elucidate their roles ..
  25. doi High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma
    Xiao Dong Zhu
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China
    J Clin Oncol 26:2707-16. 2008
    To investigate prognostic values of the intratumoral and peritumoral expression of macrophage colony-stimulating factors (M-CSF) in hepatocellular carcinoma (HCC) patients after curative resection.
  26. pmc EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Gastroenterology 136:1012-24. 2009
    ..We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence of hepatic cancer cells with stem/progenitor features.
  27. pmc Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    Takaji Wakita
    Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Nat Med 11:791-6. 2005
    ..The cell culture-generated HCV is infectious for chimpanzee. This system provides a powerful tool for studying the viral life cycle and developing antiviral strategies...
  28. doi The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    S Whittaker
    Dana Farber Cancer Institute, Boston, MA, USA
    Oncogene 29:4989-5005. 2010
    b>Hepatocellular carcinoma (HCC) is a highly prevalent, treatment-resistant malignancy with a multifaceted molecular pathogenesis...
  29. ncbi Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial
    Josep M Llovet
    Liver Unit, Digestive Disease Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 359:1734-9. 2002
    There is no standard treatment for unresectable hepatocellular carcinoma. Arterial embolisation is widely used, but evidence of survival benefits is lacking.
  30. doi MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1
    Queenie W L Wong
    Department of Anatomical and Cellular Pathology at the Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, SAR Hong Kong, China
    Gastroenterology 135:257-69. 2008
    Recent studies have emphasized causative links between microRNA (miRNA) deregulations and cancer development. In hepatocellular carcinoma (HCC), information on differentially expressed miRNA remained largely undefined.
  31. ncbi Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    Qiang Gao
    Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, People s Republic of China
    J Clin Oncol 25:2586-93. 2007
    To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection.
  32. doi Diagnosis and treatment of hepatocellular carcinoma
    Hashem B El-Serag
    Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 134:1752-63. 2008
    The diagnosis and treatment of hepatocellular carcinoma (HCC) have witnessed major changes over the past decade...
  33. doi Pilot clinical trial of localized concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma with portal vein thrombosis
    Kwang Hyub Han
    Department of Internal Medicine, Yonsei Liver Cancer Special Clinic, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Cancer 113:995-1003. 2008
    Patients with advanced hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) have a particularly grave prognosis...
  34. doi Extended O6-methylguanine methyltransferase promoter hypermethylation following n-butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of human hepatocellular carcinoma cell growth
    Yung luen Yu
    Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University and Hospital, Taichung, Taiwan
    J Agric Food Chem 58:1630-8. 2010
    ....
  35. doi Gender disparity of hepatocellular carcinoma: the roles of sex hormones
    Shiou Hwei Yeh
    Department of Microbiology, National Taiwan University and Hospital, College of Medicine, Taipei, Taiwan
    Oncology 78:172-9. 2010
    Men have a higher incidence of hepatocellular carcinoma (HCC) than women. Epidemiologic and animal studies have suggested that it might be due to the stimulatory effects of androgen and the protective effects of estrogen...
  36. doi MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma
    Heike Varnholt
    Institute for Pathology, University Hospital Cologne, Cologne, Germany
    Hepatology 47:1223-32. 2008
    ..miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma...
  37. doi MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
    Hang Su
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, PR China
    Cancer Res 69:1135-42. 2009
    ..In this study, we first evaluated the expression of 308 miRNAs in human hepatocellular carcinoma (HCC) and normal hepatic tissues and identified 29 differentially expressed miRNAs in HCC tissues...
  38. ncbi A decade's studies on metastasis of hepatocellular carcinoma
    Zhao You Tang
    Liver Cancer Institute, Zhongshan Hospital, 136 Yi Xue Yuan Road, 200032, Shanghai, PR China
    J Cancer Res Clin Oncol 130:187-96. 2004
    Metastasis remains one of the major challenges before hepatocellular carcinoma (HCC) is finally conquered. This paper summarized a decade's studies on HCC metastasis at the Liver Cancer Institute of Fudan University...
  39. ncbi A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    Ju Seog Lee
    Lab of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 4146, Bethesda, Maryland 20892, USA
    Nat Med 12:410-6. 2006
    The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests that HCC may comprise several distinct biological phenotypes...
  40. doi Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
    Shunsuke Ura
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 49:1098-112. 2009
    ..expression of 188 miRNAs in liver tissues obtained from 12 patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and 14 patients with hepatitis C virus (HCV)-related HCC, including background liver tissues and ..
  41. doi Serum markers of hepatocellular carcinoma
    Giulia Malaguarnera
    Department of Biomedical Science, University of Catania, Via Androne 83, 95124, Catania, Italy
    Dig Dis Sci 55:2744-55. 2010
    The hepatocellular carcinoma is one of the most common malignant tumors and carries a poor survival rate. The management of patients at risk for developing HCC remains intricate.
  42. ncbi Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
    Elisabetta Bugianesi
    Department of Gastroenterology, Ospedale S Giovanni Battista, University of Turin, Turin, Italy
    Gastroenterology 123:134-40. 2002
    Nonalcoholic steatohepatitis (NASH) may progress to cirrhosis; whether NASH plays also a role in the development of hepatocellular carcinoma (HCC) is unknown.
  43. doi Loco-regional treatment of hepatocellular carcinoma
    Riccardo Lencioni
    Division of Diagnostic Imaging and Intervention, Department of Liver Transplantation, Hepatology, and Infectious Diseases, Pisa University Hospital, Pisa, Italy
    Hepatology 52:762-73. 2010
    Loco-regional treatments play a key role in the management of hepatocellular carcinoma (HCC). Image-guided tumor ablation is recommended in patients with early-stage HCC when surgical options are precluded...
  44. doi Molecular mechanisms of hepatocellular carcinoma
    Rajagopal N Aravalli
    Department of Radiology, Cell Biology and Development, University of Minnesota Medical School, Minneapolis, MN, USA
    Hepatology 48:2047-63. 2008
    b>Hepatocellular carcinoma (HCC) typically has poor prognosis, because it is often diagnosed at an advanced stage...
  45. ncbi Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells
    Atsushi Suetsugu
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Biochem Biophys Res Commun 351:820-4. 2006
    ..We herein investigated whether CD133(+) cells isolated from human hepatocellular carcinoma cell lines possess cancer stem/progenitor cell-like properties...
  46. pmc New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis
    J Tian
    Liver Cancer Institute and Zhong Shan Hospital, Shanghai Medical University, Peoples Republic of China
    Br J Cancer 81:814-21. 1999
    A new human hepatocellular carcinoma (HCC) cell line with a highly metastatic potential was established from subcutaneous xenograft of a metastatic model of human HCC in nude mice (LCI-D20) by means of alternating cell culture in vitro ..
  47. ncbi Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression
    H Okabe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    Cancer Res 61:2129-37. 2001
    To disclose detailed genetic mechanisms in hepatocellular carcinoma (HCC) with a view toward development of novel therapeutic targets, we analyzed expression profiles of 20 primary HCCs and their corresponding noncancerous tissues by ..
  48. doi Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells
    Dong Ming Kuang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Guangzhou, P R China
    Hepatology 51:154-64. 2010
    ..b>Hepatocellular carcinoma (HCC) is usually derived from inflamed cirrhotic liver with extensive leukocyte infiltration...
  49. pmc MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Clin Cancer Res 15:5073-81. 2009
    Deregulated cell proliferation and apoptosis play a major role in hepatocellular carcinoma (HCC). MicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis.
  50. ncbi Hepatocellular carcinoma: current management and future trends
    Brian I Carr
    Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh Medical Center, BST, E 1552, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Gastroenterology 127:S218-24. 2004
    The hallmarks of hepatocellular carcinoma (HCC) are that it is identified clinically at an advanced stage and usually together with cirrhosis...
  51. pmc Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma
    Bin Yang
    Department of Pathology, The Johns Hopkins Medical Institutions, Pathology Building Room 406, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Pathol 163:1101-7. 2003
    b>Hepatocellular carcinoma (HCC) is one of the most fatal human malignancies, but the molecular mechanisms of hepatocarcinogenesis remain unclear...
  52. doi miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells
    Na Li
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, PR China
    Cancer Lett 275:44-53. 2009
    ..Down-regulation of miR-34a expression was highly significant in 19 of 25 (76%) human hepatocellular carcinoma (HCC) tissues compared with adjacent normal tissues and associated with the metastasis and invasion of ..
  53. doi Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
    Hongxing Zhang
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China
    Nat Genet 42:755-8. 2010
    To identify susceptibility variants for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we conducted a genome-wide association study by genotyping 440,794 SNPs in 355 chronic HBV carriers with HCC and 360 chronic HBV ..
  54. ncbi Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma
    Yingqiu Guo
    Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    Gene 384:51-61. 2006
    b>Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Several studies have identified signature gene sets that may be useful as potential diagnostic tools by global microarray analysis...
  55. doi Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development
    Masatoshi Shigoka
    Third Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Pathol Int 60:351-7. 2010
    ..In this study, we have demonstrated that miR-92a is highly expressed in hepatocellular carcinoma (HCC)...
  56. ncbi Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    Anuradha Budhu
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Cell 10:99-111. 2006
    b>Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or postsurgical recurrence. We postulate that metastases are influenced by the liver microenvironment...
  57. doi Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma
    M C Kew
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    Pathol Biol (Paris) 58:273-7. 2010
    ..people worldwide are chronically infected with hepatitis B virus (HBV) and are at high risk of developing hepatocellular carcinoma (HCC)...
  58. ncbi Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    Li Liu
    Department of Cancer Biology, Bayer HealthCare Pharmaceuticals, West Haven, Connecticut 06516, USA
    Cancer Res 66:11851-8. 2006
    ....
  59. ncbi Resection and liver transplantation for hepatocellular carcinoma
    Josep M Llovet
    BCLC Group, Liver Unit, Digestive Disease Institute, IDIBAPS, Hospital Clinic, University of Barcelona, Catalonia, Spain
    Semin Liver Dis 25:181-200. 2005
    Surveillance programs in cirrhotic patients enable the detection of hepatocellular carcinoma (HCC) at early stages, when the tumor is amenable to curative treatments (60% of cases in Japan; 25 to 40% in Europe and the United States)...
  60. doi A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma
    Teng Xu
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Guangzhou 510275, People s Republic of China
    Carcinogenesis 29:2126-31. 2008
    ..The cancer association study included 479 hepatocellular carcinoma (HCC) and 504 control subjects...
  61. doi MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma
    Wei Chih Tsai
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Hepatology 49:1571-82. 2009
    ....
  62. ncbi Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: Is resection still the treatment of choice?
    Tito Livraghi
    Department of Radiology, Ospedale Civile, Vimercate, Milano, Italy
    Hepatology 47:82-9. 2008
    If liver transplantation is not feasible, partial resection is considered the treatment of choice for hepatocellular carcinoma (HCC) in patients with cirrhosis...
  63. ncbi Hepatocellular carcinoma: an epidemiologic view
    Hashem B El-Serag
    Section of Gastroenterology and Health Services Research at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Gastroenterol 35:S72-8. 2002
    b>Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world and is estimated to cause approximately half a million deaths annually. Because of its high fatality rates, the incidence and mortality rates are almost equal...
  64. pmc Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis
    Asmaa Ibrahim Gomaa
    Department of Hepatology and Gastroenterology, Imperial College London, St Mary s Hospital Campus, Praed Street, London W2 1NY, United Kingdom
    World J Gastroenterol 14:4300-8. 2008
    b>Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world...
  65. ncbi Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA
    Katrin Panzitt
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Gastroenterology 132:330-42. 2007
    ..We searched the human genome for novel genes including ncRNAs related to hepatocellular carcinoma (HCC).
  66. pmc MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib
    Shoumei Bai
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 284:32015-27. 2009
    ....
  67. ncbi Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma
    Koichi Matsuzaki
    Department of Gastroenterology and Hepatology, Kansai Medical University, Moriguchi, Osaka, Japan
    Hepatology 46:48-57. 2007
    ..chronic hepatitis caused by hepatitis C virus (HCV) infection develop liver fibrosis with high risk for hepatocellular carcinoma (HCC), but the mechanism underling this process is unclear...
  68. pmc Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97
    Y Li
    Liver Cancer Institute and Zhongshan Hospital of Fudan University, 136 Yixueyuan Road, Shanghai 200032, China
    World J Gastroenterol 7:630-6. 2001
    ..METHODS: Cloning procedure was performed on parental hepatocellular carcinoma (HCC) cell line MHCC97, and biological characteristics of the target clones selected by in vivo screening ..
  69. ncbi Hepatocellular carcinoma pathogenesis: from genes to environment
    Paraskevi A Farazi
    Department of Genetics, Division of Medical Sciences, Harvard University, Boston, Massachusetts 02115, USA
    Nat Rev Cancer 6:674-87. 2006
    b>Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human population...
  70. ncbi Extrahepatic metastases of hepatocellular carcinoma
    S Katyal
    Department of Radiology, University of Pittsburgh Medical Center, PA 15213, USA
    Radiology 216:698-703. 2000
    To determine the relative frequency, incidence, and locations of metastases of hepatocellular carcinoma (HCC), correlate extrahepatic metastatic disease with intrahepatic tumor staging, and determine the computed tomographic (CT) ..
  71. pmc Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    Dawang Zhou
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Cell 16:425-38. 2009
    ..in loss of inhibitory Ser127 phosphorylation of the Yorkie ortholog, Yap1, massive overgrowth, and hepatocellular carcinoma (HCC)...
  72. ncbi Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker
    Tetsuya Nakatsura
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, 860 8556, Kumamoto, Japan
    Biochem Biophys Res Commun 306:16-25. 2003
    With the global pandemic of hepatitis B and C infections, the incidence of Hepatocellular carcinoma (HCC) is rapidly increasing world wide...
  73. pmc A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma
    Min shan Chen
    Department of Hepatobiliary Surgery, Cancer Centre of Sun Yat sen University, Guangzhou, China
    Ann Surg 243:321-8. 2006
    To compare the results of percutaneous local ablative therapy (PLAT) with surgical resection in the treatment of solitary and small hepatocellular carcinoma (HCC).
  74. doi MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling
    Queenie W L Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Cancer Res 16:867-75. 2010
    This study aims to profile the expressions of 156 microRNAs (miRNA) in hepatocellular carcinoma (HCC) and to characterize the functions of miR-222, the most significantly upregulated candidate identified.
  75. ncbi Hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Liver Unit, Digestive Disease Institute, IDIBAPS, Hospital Cli nic i Provincial, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain
    Lancet 362:1907-17. 2003
    b>Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer, and its incidence is increasing worldwide because of the dissemination of hepatitis B and C virus infection...
  76. doi Identification of metastasis-related microRNAs in hepatocellular carcinoma
    Anuradha Budhu
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Hepatology 47:897-907. 2008
    MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis and postsurgical recurrence...
  77. doi Hepatocellular carcinoma in the Asia pacific region
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Gastroenterol Hepatol 24:346-53. 2009
    Primary liver cancer, particularly hepatocellular carcinoma (HCC) remains a significant disease worldwide...
  78. pmc Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma
    R Tung-Ping Poon
    Centre of Liver Diseases, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Surg 232:10-24. 2000
    To evaluate the current knowledge on the risk factors for recurrence, efficacy of adjuvant therapy in preventing recurrence, and the optimal management of recurrence after resection of hepatocellular carcinoma (HCC).
  79. doi High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma
    Xin Rong Yang
    Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, 136 Yi Xue Yuan Road, Shanghai, PR China
    Gut 59:953-62. 2010
    To investigate the prognostic values of putative hepatic stem/progenitor cell (HSC/HPC) biomarkers in patients with hepatocellular carcinoma (HCC).
  80. doi Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter
    Seung Oe Lim
    Department of Biological Sciences, Seoul National University, Seoul, Korea
    Gastroenterology 135:2128-40, 2140.e1-8. 2008
    ..We sought to determine whether ROS promote hypermethylation of the promoter region of E-cadherin, a regulator of the epithelial-to-mesenchymal transition, in hepatocellular carcinoma (HCC) cells.
  81. ncbi Hepatocellular carcinoma and hepatitis C in the United States
    Hashem B El-Serag
    Sections of Gastroenterology and Health Services Research at the Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, 77030, USA
    Hepatology 36:S74-83. 2002
    Chronic infection with hepatitis C virus (HCV) is a major risk factor for development of hepatocellular carcinoma (HCC)...
  82. doi A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells
    Bastian Hoechst
    Medizinische Hochschule Hannover, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany
    Gastroenterology 135:234-43. 2008
    Several studies have shown that development of hepatocellular carcinoma (HCC) generates a number of immune suppressive mechanisms in these patients...
  83. doi Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
    Muh Hwa Yang
    Institutes of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Hepatology 50:1464-74. 2009
    ..EMT markers and patient/tumor/viral factors, and the interplay between major EMT regulators in human hepatocellular carcinoma (HCC)...
  84. doi Hepatitis C virus seromarkers and subsequent risk of hepatocellular carcinoma: long-term predictors from a community-based cohort study
    Mei Hsuan Lee
    National Taiwan University, Taipei, Taiwan
    J Clin Oncol 28:4587-93. 2010
    Hepatitis C virus (HCV) contributes to one third of hepatocellular carcinoma cases worldwide. Long-term predictors for HCV-related hepatocellular carcinoma are essential for early intervention...
  85. pmc Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
    Yujin Hoshida
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA
    Cancer Res 69:7385-92. 2009
    b>Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy...
  86. ncbi Angiogenesis and hepatocellular carcinoma
    David Semela
    Institute of Clinical Pharmacology, University of Bern, 35 Murtenstrasse, Bern CH 3010, Switzerland
    J Hepatol 41:864-80. 2004
  87. doi MicroRNA-30d promotes tumor invasion and metastasis by targeting Galphai2 in hepatocellular carcinoma
    Jian Yao
    Shanghai Medical College, Fudan University, Shanghai, China
    Hepatology 51:846-56. 2010
    ..underlying molecular mechanisms through which miRNAs are involved in the development and progression of hepatocellular carcinoma (HCC)...
  88. ncbi Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Japan
    Hepatology 40:1396-405. 2004
    ..and tumor-node-metastasis staging, has been proposed as a better prognostic staging system for hepatocellular carcinoma (HCC) than the Cancer of the Liver Italian Program (CLIP) scoring system...
  89. ncbi Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
    Diego F Calvisi
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4262, USA
    Gastroenterology 130:1117-28. 2006
    Although the natural history and pathologic characteristics of human hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC remains poorly understood...
  90. pmc Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis
    S J Schoenleber
    Mayo Medical School, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Cancer 100:1385-92. 2009
    b>Hepatocellular carcinoma (HCC) is a highly vascular tumour that expresses vascular endothelial growth factor (VEGF). Various studies have evaluated the prognostic value of VEGF levels in HCC...
  91. doi MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma
    Yusuke Yamamoto
    Section for Studies on Metastasis, National Cancer Center Research Institute, 1 1 Tsukiji, 5 Chome, Chuo Ku, Tokyo 104 0045, Japan
    Biomarkers 14:529-38. 2009
    ..miR-500 was abundantly expressed in several human liver cancer cell lines and 45% of human hepatocellular carcinoma (HCC) tissue. Most importantly, an increased amount of miR-500 was found in the sera of the HCC patients...
  92. doi The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma
    Satoshi Shimizu
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Hepatol 52:698-704. 2010
    Bcl-xL, an anti-apoptotic member of the Bcl-2 family, is over-expressed in human hepatocellular carcinoma, conferring a survival advantage to tumour cells. The mechanisms underlying its dysregulation have not been clarified...
  93. doi Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus
    Bart J Veldt
    Erasmus MC University Medical Center, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands
    Hepatology 47:1856-62. 2008
    Recent studies suggest that diabetes mellitus increases the risk of developing hepatocellular carcinoma (HCC)...
  94. doi The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    Mustafa S Ascha
    Department of Gastroenterology and Hepatology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 51:1972-8. 2010
    ..is a well-recognized cause of cirrhosis and has been increasingly associated with the development of hepatocellular carcinoma (HCC)...
  95. doi Liver transplantation for hepatocellular carcinoma: Hangzhou experiences
    Shu Sen Zheng
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
    Transplantation 85:1726-32. 2008
    Liver transplantation (LT) has been the treatment of choice for patients with hepatocellular carcinoma (HCC)...
  96. ncbi The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence
    Hashem B El-Serag
    Section of Gastroenterology, Michael E DeBakey Veterans Affairs Medical Center at Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 4:369-80. 2006
    We conducted a systematic review and a meta-analysis to estimate the magnitude and determinants of association between diabetes and hepatocellular carcinoma (HCC).
  97. pmc Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma
    Michelle Z Xu
    Department of Surgery and Center for Cancer Research, The University of Hong Kong, Pokfulam, Hong Kong
    Cancer 115:4576-85. 2009
    ..downstream target of the Hippo signaling pathway, was recently linked to hepatocarcinogenesis in a mouse hepatocellular carcinoma (HCC) model...
  98. pmc Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    Yujin Hoshida
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    N Engl J Med 359:1995-2004. 2008
    It is a challenge to identify patients who, after undergoing potentially curative treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk patients could receive novel interventional measures...
  99. pmc The changing pattern of epidemiology in hepatocellular carcinoma
    Helena Nordenstedt
    Karolinska Institute, Stockholm, Sweden
    Dig Liver Dis 42:S206-14. 2010
    ..Obesity and diabetes are increasing at a fast pace throughout the world, and if they are proven to be HCC risk factors, they would account for more HCC cases in the future...
  100. doi MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma
    Shuai Li
    Beijing Institute of Radiation Medicine, Beijing, China
    Hepatology 49:1194-202. 2009
    ..that some microRNAs can function as oncogenes or tumor suppressors, the specific role of miRNA in human hepatocellular carcinoma (HCC) is unclear at this point...
  101. ncbi From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now
    Roberta W C Pang
    Department of Medicine, Centre for Cancer Research, The University of Hong Kong, Hong Kong, SAR, China
    Oncology 72:30-44. 2007
    b>Hepatocellular carcinoma (HCC) is characterized as a highly chemoresistant cancer with no effective systemic therapy...

Research Grants81

  1. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2013
    ..of gonadoblastoma, testicular germ cell tumors, prostate cancer, and sexual dimorphic cancers, such as hepatocellular carcinoma. TSPY potentiates cell proliferation, accelerates the transition and disrupts the G2/M checkpoints, binds ..
  2. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Whether UBC9 is deregulated in hepatocellular carcinoma (HCC) is unknown. How UBC9 protein stability is regulated post-translationally is also unknown...
  3. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..persons chronically infected with HBV and remain at an increased risk of disease sequelae including hepatocellular carcinoma.[10] Alaska Native persons chronically infected with HBV also exhibited increased incidence of ..
  4. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..is implicated in both acute acetaminophen-induced liver failure and chronic liver diseases, cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic pathways have been identified...
  5. Med1 in Liver Metabolism, Regeneration and Cancer
    Janardan K Reddy; Fiscal Year: 2013
    ..Med1 also controls liver regeneration and the development of hepatocellular carcinoma (HCC), in that hepatocytes lacking Med1 fail to regenerate and fail to give rise to liver tumors...
  6. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..models of human tumors, JS-K is highly effective against acute myeloid leukemia, prostate cancer, hepatocellular carcinoma, multiple myeloma and non-small cell lung cancer...
  7. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..It can be a precursor to cirrhosis, hepatocellular carcinoma and end-stage liver disease...
  8. Iron-Induced Changes in Liver That Predispose to Malignancy
    Harriet C Isom; Fiscal Year: 2010
    b>Hepatocellular carcinoma (HCC) is one of the most common causes of cancer death and is on the rise in the United States. Preventative strategies are highly important in reducing the incidence and death from HCC...
  9. Roles for microRNA-122 in hepatitis C virus RNA amplification
    Peter Sarnow; Fiscal Year: 2013
    ..not resolve the infection and develop chronic infections that often lead to end-stage liver disease and hepatocellular carcinoma. Current treatment is limited to a combination therapy of ribavirin and interferon 1...
  10. Novel Reagents and Methods for Rapid and High Throughput Detection of Aflatoxin C
    ALAN AI PING WEI; Fiscal Year: 2013
    ..They affect 4.5 billion people worldwide and causes up to 150,000 cases of hepatocellular carcinoma each year. In the U.S., mandatory testing is required by the 1990 Farm Bill that stipulates ".....
  11. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond F Novak; Fiscal Year: 2010
    ..increases the risk of developing chronic non-alcoholic liver disease, non-alcoholic steatohepatitis, and hepatocellular carcinoma. DM elevates CYP2E1, which is critically important in human health, because it increases oxidative stress,..
  12. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    ..includes alcoholic fatty liver, alcoholic steatohepatitis, alcoholic cirrhosis, and increased risk of hepatocellular carcinoma. The pathological mechanisms of ALD involves complex interactions between the direct effects of alcohol ..
  13. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..with HBV leading to nearly one million deaths annually as a result of cirrhosis, liver failure and hepatocellular carcinoma (HCC)...
  14. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..roles of infection with hepatitis B virus and co-exposure to the fungal toxin aflatoxin on human risk for hepatocellular carcinoma, we will purse three aims...
  15. Mechanism(s) of Hepatocyte Transformation by the Hepatitis B Virus X Protein
    Ourania M Andrisani; Fiscal Year: 2013
    ..by applicant): Chronic Hepatitis B Virus (HBV) infection is a major factor in the pathogenesis of hepatocellular carcinoma (HCC)...
  16. Aryl Hydrocarbon Receptor Modulators for the Treatment of Hepatocellular Carcinom
    Siva Kumar Kolluri; Fiscal Year: 2012
    ..capable of initiating biological responses that should prove useful for prevention and/or treatment of hepatocellular carcinoma. We propose to identify SAhRMs by in silico structure-based Virtual Ligand Screening (VLS) coupled with ..
  17. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..NAFLD affects 30% of Americans and can lead to cirrhosis and hepatocellular carcinoma. More than 12 million Americans are estimated to suffer from OSA which worsens metabolic disease and ..
  18. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    ..350 million people worldwide and is a significant risk factor for severe liver disease, including hepatocellular carcinoma (HCC)...
  19. Heat Shock Protein Synthesis Inhibitor Treatment of Hepatitis C Viral Infection
    SAMUEL WHEELER FRENCH; Fiscal Year: 2013
    ..may allow for successful treatment of chronic hepatitis C and reduce the incidence of cirrhosis and hepatocellular carcinoma. PUBLIC HEALTH RELEVANCE: Chronic hepatitis C viral (HCV) infection is the number one causative agent of ..
  20. Structure and Function of the Hepatitis C Virus Genome
    Peter Sarnow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Approximately 80% of hepatocellular carcinoma, a leading cause of cancer-related deaths, is caused by infection with either hepatitis B or hepatitis C virus (HCV)...
  21. Detection of Liver Fibrosis Using IVIM Diffusion and DCE MRI in HCV
    Bachir Taouli; Fiscal Year: 2013
    ..increased risks of liver damage, including fibrosis and cirrhosis, which may eventually lead to hepatocellular carcinoma and end-stage liver disease requiring liver transplantation...
  22. ROLE OF SAMe IN LIVER FUNCTION AND INJURY
    SHELLY CHI LOO LU; Fiscal Year: 2012
    ..mice with chronic hepatic SAMe deficiency have increased oxidative stress, develop steatohepatitis and hepatocellular carcinoma (HCC)...
  23. Aberrant DNA Methylation of MicroRNA Genes in Hepatocellular Carcinoma (HCC)
    Jing Shen; Fiscal Year: 2012
    ..gene silencing by promoter DNA methylation is an important mechanism of tumorigenesis, including in hepatocellular carcinoma (HCC)...
  24. Hepatocyte Nox proteins in the pathogenesis of hepatocellular carcinoma
    Jinah Choi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis C virus is a major etiologic agent of hepatocellular carcinoma (HCC). HCV-induced HCC is typically preceded by chronic hepatitis and cirrhosis...
  25. Role of Heat Shock Transcription Factor Hsf1 in Tumorigenesis
    Nahid F Mivechi; Fiscal Year: 2013
    ..we plan to determine the impact of Hsf1 deletion in two tumor model systems: (1) a chemically induced hepatocellular carcinoma (HCC) that is a well-established model for chronic inflammation-induced cancer, and (2) a model of ..
  26. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..This project focuses on the role of the loss of function of miR-122 in the development and progression of hepatocellular carcinoma (HCC), one of the most common human malignancies...
  27. Inactivation of Hdac3 in the cause, prevention, and treatment of HCC
    Scott W Hiebert; Fiscal Year: 2013
    ..in DNA repair and genomic instability, the liver-specific deletion of Hdac3 caused a 100% penetrant hepatocellular carcinoma with a mean time to HCC of 10.2 months...
  28. Combination therapies for chronic HBV, liver disease and cancer
    Mark A Feitelson; Fiscal Year: 2012
    ..HBV) and are at high risk for the development of hepatitis, cirrhosis (end stage liver disease) and hepatocellular carcinoma (HCC)...
  29. Hepatocarcinogenesis Secondary to Hepatitis C
    Srikanta Dash; Fiscal Year: 2012
    ..is now believed that long-standing chronic inflammation secondary to HCV infection is the main cause of hepatocellular carcinoma. The mechanisms underlying the development of long-lasting chronic inflammation and cancer are not well ..
  30. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..Diseases caused by chronic HCV infection include acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV infection also correlates with high prevalence of fatty liver (steatosis) in patients, which may ..
  31. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei L Gartel; Fiscal Year: 2012
    Human hepatocellular carcinoma (HCC) is the fifth most common cancer, and the third leading cause of cancer death worldwide. All conventional treatments for liver cancer are fraught with side effects and limited efficiency...
  32. Epigenetic Regulation Of Sex-dependent Liver Cancer
    Arlin B Rogers; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma HCC) arises in men more than three times as often as women...
  33. Mechanisms and metabolic implications of LRP130 in NAFLD
    Marcus P Cooper; Fiscal Year: 2013
    ..NASH predisposes to irreversible cirrhosis and hepatocellular carcinoma, which highlights the need to identify underlying mechanisms...
  34. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    DESCRIPTION (Provided by applicant): Hepatocellular carcinoma (HCC) has been correlated with specific p53 mutations and exposure to aflatoxin B1 (AFB1). Individual response to liver carcinogens shows great variability...
  35. Role of sumoylation in alcoholic liver disease
    Maria Lauda Tomasi; Fiscal Year: 2013
    ..Alcoholic Liver Diseases (ALD) includes simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Sumoylation is a post-translational modification that modulates multiple cellular processes such as ..
  36. Role of Polo-like kinase (Plk-1) in Hepatitis B Virus-mediated Hepatocellular Car
    Ourania M Andrisani; Fiscal Year: 2010
    Chronic Hepatitis B virus (HBV) infection is linked to hepatocellular carcinoma (HCC). The HBV X protein (pX) is implicated in HCC pathogenesis by an unknown mechanism...
  37. Cell death regulation in proteotoxic therapy
    Wei Xing Zong; Fiscal Year: 2013
    ..advanced human cancers such as squamous cell carcinomas of lung, head and neck, and esophagus, as well as hepatocellular carcinoma and breast carcinoma...
  38. Gene Therapy for Retinitis Pigmentosa
    Rajendra Kumar-Singh; Fiscal Year: 2012
    ..Furthermore, AAV has been recently shown to cause hepatocellular carcinoma at the alarmingly high rate of 56% in animals by insertional mutagenesis...
  39. MECHANISMS OF LIVER INJURY BY HEPATITIS C AND ALCOHOL
    Steven A Weinman; Fiscal Year: 2013
    ..a more severe liver disease than either condition alone with increased rates of both cirrhosis and hepatocellular carcinoma. We have recently discovered that the combination of HCV and alcohol causes a loss in the activity of the ..
  40. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is a major malignancy worldwide...
  41. Hepatitis C virus and liver fibrogenesis
    Gulam Waris; Fiscal Year: 2010
    ..to chronic hepatitis in up to 60-80% of infected adults and progresses to liver fibrosis, cirrhosis and hepatocellular carcinoma. The mechanisms underlying the liver injury and fibrosis in chronic hepatitis C are unclear...
  42. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
    ..cellular basis for the development of hepatic fibrosis-a reversible condition-that can lead to cirrhosis, hepatocellular carcinoma, and need for liver transplantation...
  43. DNA Repair of Endogenous Lesions in Carcinogenesis
    Rabindra Roy; Fiscal Year: 2010
    ..The LEG rat is genetically predisposed to spontaneous hepatocellular carcinoma (HCC)...
  44. Mechanistic Studies of HCV E2
    Joseph Marcotrigiano; Fiscal Year: 2013
    ..In many cases HCV infection becomes chronic, which can progress to liver cirrhosis and hepatocellular carcinoma. There is no vaccine available for HCV and the only treatment is pegylated interferon-? in combination ..
  45. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    ..Steven Curley (co-mentor) will provide guidance in the clinical features of hepatocellular carcinoma (HCC);and Dr...
  46. Prevention of EtOH-induced promotion of hepatocarcinogenesis by genistein/soy
    Martin J J Ronis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is now the world's third leading cause of cancer mortality. Alcohol is a well known risk factor for HCC and is suggested to account for 32-45% of all HCC cases...
  47. Novel Therapeutic Vaccines for Chronic HBV
    ROBERT GERALD WHALEN; Fiscal Year: 2013
    ..5-1.2 million deaths per year. Adults with chronic HBV infection acquired in the perinatal period develop hepatocellular carcinoma at a rate of about 5% per decade, approximately 100-fold higher than the rate among uninfected ..
  48. Antiviral prophylaxis to prevent perinatal transmission of HBV in Thailand
    GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2013
    ..Chronic HBV, complicated by cirrhosis and hepatocellular carcinoma (HCC), is the 10th leading cause of death worldwide. About 7% of Thai adults are HBsAg carriers...
  49. Antisense Mediated Treatment of Hepatitis B Virus Infection
    STEFAN FRANK WIELAND; Fiscal Year: 2013
    ..causes acute and chronic hepatitis and kills a million people each year from cirrhosis of the liver and hepatocellular carcinoma. Currently approved therapies for the treatment of chronic hepatitis B include two classes of drugs: ..
  50. IKKbeta:Bi-Functional Regulator of Hepatocyte Proliferation
    Hyam L Leffert; Fiscal Year: 2010
    ..hepatectomy, mouse liver regeneration starts faster and the diethylnitrosamine- induced incidence of hepatocellular carcinoma (HCC) is higher in mice carrying targeted hepatocyte-specific IKK[unreadable] deletions...
  51. Mechanisms of glucagon-like peptide 1 (GLP-1) in fatty liver disease
    Frank A Anania; Fiscal Year: 2013
    ..number of Americans will develop liver injury from hepatic fat stores including hepatitis, cirrhosis, and hepatocellular carcinoma (HCC)...
  52. GROWTH CONTROL OF NORMAL AND CIRRHOTIC HEPATOCYTES
    Kevin E Behrns; Fiscal Year: 2010
    ..incidence and prevalence in the United States and is closely associated with the development of hepatocellular carcinoma, which has a dismal long-term prognosis...
  53. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    ..by applicant): Hepatitis B virus (HBV) causes acute and chronic necroinflammatory liver disease and hepatocellular carcinoma (HCC)...
  54. Catalytic inactivation of miRNA function by customized RNase P-based ribozymes
    DANIEL R contact SCHOENBERG; Fiscal Year: 2010
    ..microRNA miR-122 also plays a central role in the pathogenesis of Hepatitis C virus (HCV) and associated hepatocellular carcinoma by stimulating viral replication through its binding to target sites in the 5'noncoding region of ..
  55. Murine Model of HCV-Associated Human Liver Cancer
    Lishan Su; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Chronic hepatitis C virus (HCV) infection is now the leading cause of hepatocellular carcinoma (HCC), a highly lethal cancer with rapidly increasing incidence in the U.S...
  56. HCV Strain Variation and HCC
    Andrea D Branch; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality in the world...
  57. Role of POZ-zinc finger proteins in tumorigenesis.
    Pier Paolo Pandolfi; Fiscal Year: 2013
    ..Our analysis of the expression of LRF in human cancers shows an ectopic expression of LRF in hepatocellular carcinoma, while it has recently been shown that the LRF gene is amplified in non small cell lung cancer (NSCLCs)...
  58. Signaling of Integrin Alpha 7
    Jianhua Luo; Fiscal Year: 2009
    ..We found mutations of ITGA7 in prostate cancer, hepatocellular carcinoma, leiomyosarcoma and glioblastoma multiforme with frequencies ranging from 25% to 83%...
  59. Role of Hepatitis B virus X protein in HBV replication
    Michael J Bouchard; Fiscal Year: 2011
    ..with a chronic hepatitis B virus (HBV) infection of the liver have an increased risk for developing hepatocellular carcinoma (HCC)...
  60. Carboxylesterase-activated Doxazolidine-prodrug for Hepatocellular Carcinoma
    Tad H Koch; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths world-wide. In spite of its relatively low occurrence in the U.S...
  61. Volumetric Perfusion MRI of Liver Tumors to Detect Early Response to Chemotherapy
    Scott B Reeder; Fiscal Year: 2010
    ..drug) results in a 3-month improvement in overall survival in advanced primary liver tumors (hepatocellular carcinoma (HCC)), while only 3% of tumors actually decreased in size...
  62. Dissecting the Role of Unfolded Protein Response in Alcoholic Liver Disease
    Ling Qi; Fiscal Year: 2013
    ..and can lead to more severe forms of liver injury, including cirrhosis, diabetes, hepatitis, fibrosis and hepatocellular carcinoma. Therefore, understanding the pathogenesis of alcohol-induced fatty liver disease is of great clinical ..
  63. FAH-Deficient Pigs
    Scott L Nyberg; Fiscal Year: 2011
    ..new therapies for metabolic liver disorders, acute liver failure, chronic (cirrhotic) liver disease, an hepatocellular carcinoma. While new transgenic and knockout rodent models of liver disease have facilitated basic research, the ..
  64. Structure and Function of the Hepatitis C Virus Genome
    PETER contact SARNOW; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Approximately 80% of hepatocellular carcinoma, a leading cause of cancer-related deaths, is caused by infection with either hepatitis B or hepatitis C virus (HCV)...
  65. 2010 Molecular Biology of Hepatitis B Viruses Meeting
    Adam Zlotnick; Fiscal Year: 2010
    ..HBV contributes to the deaths of some 600,000 people annually mainly by liver failure, cirrhosis, and hepatocellular carcinoma. In addition to significant morbidity, acute HBV infection is correlated with pancreatic cancer...
  66. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  67. Analysis of the Cytokine-Immunological Model of a Cancer-Related Symptom Cluster
    Jennifer Steel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide and in the next decade the incidence of HCC is expected to increase in the U.S...
  68. Hepatitis B Virus PreS2 Mutant as Risk Factor for Hepatocellular Carcinoma
    Eric J Huang; Fiscal Year: 2010
    ..B virus (HBV) is a major cause of serious liver diseases, including chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC) throughout the world and the US, especially among minorities such as African Americans, Native ..
  69. Peptide Biomarker Discovery by Mass Spectrometry for Early Detection of Liver Can
    Habtom Ressom; Fiscal Year: 2009
    ..The optimized analytical tools will be applied to find and validate markers that detect hepatocellular carcinoma (HCC) at a treatable stage...
  70. Engineered 3-D Human Liver Tissue for Hepatitis Studies
    BRIAN NAUGHTON; Fiscal Year: 2004
    ..HCV infection of the liver progresses to cirrhosis followed by hepatocellular carcinoma and ultimately liver failure, and is the leading reason for liver transplantation...
  71. RAT MODEL OF TRANSPLANTABLE HEPATOCELLULAR CARCINOMA
    Douglas Hixson; Fiscal Year: 1992
    The goal of this proposal is to establish a well-characterizes rat model of hepatocellular carcinoma which can be use in studies on the interaction between progressive neoplastic disease and the host immune system...
  72. Diagnosing and monitoring NAFLD using unbound FFA profiles
    Alan Kleinfeld; Fiscal Year: 2009
    ..a progressive disease in which simple steatosis can lead to steatohepatitis, cirrhosis, liver failure and hepatocellular carcinoma. The prevalence of NAFLD is closely linked to obesity and obesity-related co-morbidities such as insulin ..
  73. Racial Differences in IFN Transcriptional Response
    Daryl Lau; Fiscal Year: 2009
    ..It is associated with progressive hepatic fibrosis, cirrhosis and increased risk of hepatocellular carcinoma. Approximately 2...
  74. Small Molecule Inhibitors of HBV/HCV Induced Liver Diseases
    Surendra Dheer; Fiscal Year: 2009
    ABSTRACT Hepatocellular carcinoma (HCC) is one of the most common malignancy, representing more than 5% of all cancers, and its incidence is rising rapidly worldwide...
  75. Hepatitis Virus, Alcohol Exposure and Oxidative Stress
    Manal Hassan; Fiscal Year: 2002
    ..by applicant) Hepatitis C virus (HCV) infection and alcohol abuse are the 2 major risk factors for hepatocellular carcinoma (HCC) in this country...
  76. Innate Control of Hepatitis C Virus Infection: Antiviral and Evasion Mechanisms
    FRANCIS CHISARI; Fiscal Year: 2009
    ..HCV is a noncytopathic, positive-strand RNA virus that causes acute and chronic hepatitis and hepatocellular carcinoma. Approximately 2-4 million persons are chronically infected by HCV in the USA and 170 million people are ..
  77. METAL INDUCED INJURY IN HEPATOCYTES
    Harriet Isom; Fiscal Year: 2006
    ..and Beta-catenin has been correlated with poor prognosis and reduced survival time of patients with hepatocellular carcinoma and the level of E-cadherin expression has been shown to be inversely related to hepatocellular carcinoma ..
  78. PreS2 Mutant of Hepatitis B Virus as Early Marker of Hepatocellular Carcinoma
    TIEN SZE YEN; Fiscal Year: 2007
    ..B virus (HBV) is a major cause of serious liver diseases, including chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC) throughout the world and the US, especially among minorities such as African Americans, Native ..
  79. Raf Kinase Inhibitory Protein (RKIP): A New Hepatocellular Carcinoma Tumor Suppre
    John M Sedivy; Fiscal Year: 2010
    b>Hepatocellular carcinoma (HCC) accounts for 80-90% of primary liver tumors, and is one of the most common and devastating malignant diseases worldwide...
  80. Adiponectin effects on leptin signaling in hepatocellular carcinoma
    Neeraj Kumar Saxena; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Obesity is an independent risk factor for hepatocellular carcinoma (HCC). Obese patients exhibit a higher risk for larger tumor burden, increased metastasis and poor prognosis...
  81. Dysregulation of the Tumor Microenvironment in Hepatocellular Carcinoma
    Lewis R Roberts; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. The stromal changes underlying the development and progression of HCC are important but incompletely understood...