colonic neoplasms

Summary

Summary: Tumors or cancer of the COLON.

Top Publications

  1. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
  2. ncbi Identification and expansion of human colon-cancer-initiating cells
    Lucia Ricci-Vitiani
    Department of Hematology and Oncology, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Nature 445:111-5. 2007
  3. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
  4. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
  5. ncbi Crypt stem cells as the cells-of-origin of intestinal cancer
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht and University Medical Centre Utrecht, Netherlands
    Nature 457:608-11. 2009
  6. pmc Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    Emina H Huang
    Department of Surgery, University of Florida, Gainesville, Florida, USA
    Cancer Res 69:3382-9. 2009
  7. pmc MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma
    Aaron J Schetter
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA 299:425-36. 2008
  8. ncbi Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    Louis Vermeulen
    Laboratory for Experimental Oncology and Radiobiology LEXOR, Center for Experimental Molecular Medicine CEMM, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Nat Cell Biol 12:468-76. 2010
  9. ncbi Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    Jessica B O'Connell
    Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Ave, Rm 72 215 CHS, Los Angeles, CA 90095, USA
    J Natl Cancer Inst 96:1420-5. 2004
  10. pmc The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    M Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:5522-7. 1999

Detail Information

Publications344 found, 100 shown here

  1. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
    ....
  2. ncbi Identification and expansion of human colon-cancer-initiating cells
    Lucia Ricci-Vitiani
    Department of Hematology and Oncology, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Nature 445:111-5. 2007
    ..We conclude that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies...
  3. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
    ..These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin...
  4. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
  5. ncbi Crypt stem cells as the cells-of-origin of intestinal cancer
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht and University Medical Centre Utrecht, Netherlands
    Nature 457:608-11. 2009
    ..Even after 30weeks, large adenomas are very rare in these mice. We conclude that stem-cell-specific loss of Apc results in progressively growing neoplasia...
  6. pmc Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    Emina H Huang
    Department of Surgery, University of Florida, Gainesville, Florida, USA
    Cancer Res 69:3382-9. 2009
    ..These findings also support our original hypothesis, derived previously from mathematical modeling of crypt dynamics, that progressive colonic SC overpopulation occurs during colon tumorigenesis and drives CRC development...
  7. pmc MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma
    Aaron J Schetter
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA 299:425-36. 2008
    ..MicroRNAs have potential as diagnostic biomarkers and therapeutic targets in cancer. No study has evaluated the association between microRNA expression patterns and colon cancer prognosis or therapeutic outcome...
  8. ncbi Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    Louis Vermeulen
    Laboratory for Experimental Oncology and Radiobiology LEXOR, Center for Experimental Molecular Medicine CEMM, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Nat Cell Biol 12:468-76. 2010
    ..We therefore propose that stemness of colon cancer cells is in part orchestrated by the microenvironment and is a much more dynamic quality than previously expected that can be defined by high Wnt activity...
  9. ncbi Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    Jessica B O'Connell
    Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Ave, Rm 72 215 CHS, Los Angeles, CA 90095, USA
    J Natl Cancer Inst 96:1420-5. 2004
    ..Using nationally representative Surveillance, Epidemiology, and End Results (SEER) data, we compared survival rates associated with colon cancer stages defined according to both AJCC systems...
  10. pmc The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    M Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:5522-7. 1999
    ..Increased beta-catenin levels may thus promote neoplastic conversion by triggering cyclin D1 gene expression and, consequently, uncontrolled progression into the cell cycle...
  11. pmc CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    Sergey V Shmelkov
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:2111-20. 2008
    ....
  12. ncbi Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    Thierry Andre
    Hopital Tenon, Paris
    N Engl J Med 350:2343-51. 2004
    ..Oxaliplatin improves the efficacy of this combination in patients with metastatic colorectal cancer. We evaluated the efficacy of treatment with FL plus oxaliplatin in the postoperative adjuvant setting...
  13. ncbi IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    Florian R Greten
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA
    Cell 118:285-96. 2004
    ..In addition to suppressing apoptosis in advanced tumors, IKKbeta may link inflammation to cancer...
  14. ncbi The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
    Anna Merlos-Suarez
    Oncology Program, Institute for Research in Biomedicine IRB, Baldiri Reixac 10, 08028 Barcelona, Spain
    Cell Stem Cell 8:511-24. 2011
    ..Taken together, our data suggest that the ISC program defines a cancer stem cell niche within colorectal tumors and plays a central role in CRC relapse...
  15. ncbi Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    Matilde Todaro
    Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, 90127 Palermo, Italy
    Cell Stem Cell 1:389-402. 2007
    ..Our data suggest that colon tumor growth is dictated by stem-like cells that are treatment resistant due to the autocrine production of IL-4...
  16. ncbi American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    Carmen J Allegra
    Division of Hematology Oncology, Department of Medicine, University of Florida Shands CancerCenter, Gainesville, FL, USA
    J Clin Oncol 27:2091-6. 2009
    ....
  17. ncbi Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial
    Thierry Andre
    Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, Paris 75012, France
    J Clin Oncol 27:3109-16. 2009
    ..7% at 48 months. CONCLUSION Adding oxaliplatin to LV5FU2 significantly improved 5-year DFS and 6-year OS in the adjuvant treatment of stage II or III colon cancer and should be considered after surgery for patients with stage III disease...
  18. ncbi Diagnostic and prognostic microRNAs in stage II colon cancer
    Troels Schepeler
    Department of Clinical Biochemistry, Molecular Diagnostic Laboratory, Aarhus University Hospital, Aarhus N, Denmark
    Cancer Res 68:6416-24. 2008
    ....
  19. pmc Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
    L Vermeulen
    Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9 1105 AZ, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:13427-32. 2008
    ..These data support the hypothesis that tumor hierarchy can be traced back to a single CSC that contains multilineage differentiation capacity, and provides clues to the regulation of differentiation in colon cancers in vivo...
  20. pmc A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    Shaoguang Wu
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 15:1016-22. 2009
    ..These results show a Stat3- and T(H)17-dependent pathway for inflammation-induced cancer by a common human commensal bacterium, providing new mechanistic insight into human colon carcinogenesis...
  21. ncbi Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    O Tetsu
    University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143 0128, USA
    Nature 398:422-6. 1999
    ..Abnormal levels of beta-catenin may therefore contribute to neoplastic transformation by causing accumulation of cyclin D1...
  22. ncbi Inflammation and colon cancer
    Janos Terzic
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Gastroenterology 138:2101-2114.e5. 2010
    ..These mechanisms, as well as new approaches to prevention and therapy, are discussed in this review...
  23. pmc A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
    Ji Luo
    Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cell 137:835-48. 2009
    ..Our results suggest a previously underappreciated role for Ras in mitotic progression and demonstrate a pharmacologically tractable pathway for the potential treatment of cancers harboring Ras mutations...
  24. pmc Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    Boryana K Popivanova
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Clin Invest 118:560-70. 2008
    ..These observations identify TNF-alpha as a crucial mediator of the initiation and progression of colitis-associated colon carcinogenesis and suggest that targeting TNF-alpha may be useful in treating colon cancer in individuals with UC...
  25. pmc Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer
    Sergei I Grivennikov
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA
    Cytokine Growth Factor Rev 21:11-9. 2010
    ..In addition to explaining the molecular pathogenesis of cancer, these interactions also offer opportunities for the design of new therapeutic interventions...
  26. pmc CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 USA
    Gut 58:90-6. 2009
    ..The independent effect of CIMP, MSI and BRAF mutation on prognosis remains uncertain...
  27. pmc Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer
    Daniel J Sargent
    Division of Biomedical Statistics and Informatics, Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 28:3219-26. 2010
    ..We examined MMR status as a predictor of adjuvant therapy benefit in patients with stages II and III colon cancer...
  28. ncbi Identification of FAP locus genes from chromosome 5q21
    K W Kinzler
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 253:661-5. 1991
    ..Both genes were also expressed in a wide variety of tissues. Further studies of MCC and APC and their potential interaction should prove useful for understanding colorectal neoplasia...
  29. ncbi Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation
    Chuan Ming Xie
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Free Radic Biol Med 51:1365-75. 2011
    ..Our findings unveil a novel mechanism of drug action by bufalin in colon cancer cells and open up the possibility of treating colorectal cancer through a ROS-dependent autophagy pathway...
  30. ncbi Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial
    Antonio M Lacy
    Department of Surgery, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain
    Lancet 359:2224-9. 2002
    ..Our study aimed to compare efficacy of LAC and open colectomy (OC) for treatment of non-metastatic colon cancer in terms of tumour recurrence and survival...
  31. ncbi PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
    Susan Wee
    Novartis Institutes for BioMedical Research, Cambridge, MA, USA
    Cancer Res 69:4286-93. 2009
    ..Our study provides molecular insights that help explain the heterogeneous response of KRAS mutant cancers to MEK pathway inhibition and presents a strong rationale for the clinical testing of combination MEK and PI3K targeted therapies...
  32. ncbi Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
    ..An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion...
  33. ncbi Colon cancer stem cells: promise of targeted therapy
    Matilde Todaro
    Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, Palermo, Italy
    Gastroenterology 138:2151-62. 2010
    ..How can we identify and analyze colon CSCs and what agents are being designed to kill this chemotherapy-refractory population?..
  34. ncbi ras oncogenes in human cancer: a review
    J L Bos
    Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden, The Netherlands
    Cancer Res 49:4682-9. 1989
    ..There is some evidence that environmental agents may be involved in the induction of the mutations...
  35. pmc p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest
    Christian J Braun
    Department of Molecular Oncology, Göttingen Center of Molecular Biosciences, University of Gottingen, Gottingen, Germany
    Cancer Res 68:10094-104. 2008
    ..Hence, miR-192 and miR-215 can act as effectors as well as regulators of p53; they seem to suppress cancerogenesis through p21 accumulation and cell cycle arrest...
  36. ncbi Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Cancer Res 65:6063-9. 2005
    ....
  37. ncbi Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial
    James Fleshman
    Department of Surgery, Washington University School of Medicine, MO, and Department of General and Colorectal Surgery, St Joseph Mercy Hospital, MI, USA
    Ann Surg 246:655-62; discussion 662-4. 2007
    ....
  38. ncbi The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer
    Jose Manuel Gonzalez-Sancho
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier 4, E 28029 Madrid, Spain
    Oncogene 24:1098-103. 2005
    ..Our data indicate that the Wnt/beta-catenin pathway is downregulated by the induction of DKK-1 expression, a mechanism that is lost in colon cancer...
  39. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
    ..Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression...
  40. ncbi Initial study of microRNA expression profiles of colonic cancer without lymph node metastasis
    Ying Xin Wang
    Tongji Institute of Digestive Diseases, Department of Gastroenterology, Tongji Hospital, Tongji University, Shanghai, China
    J Dig Dis 11:50-4. 2010
    ....
  41. pmc The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres
    Shailender S Kanwar
    Department of Internal Medicine, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Mol Cancer 9:212. 2010
    ..Human colon cancer cells HCT-116 (p53 wild type; K-ras mutant), HCT-116 (p53 null; K-ras mutant) and HT-29 (p53 mutant) were used...
  42. ncbi Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
    Yeshayahu Schlesinger
    Department of Cellular Biochemistry and Human Genetics, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Genet 39:232-6. 2007
    ..These results suggest that tumor-specific targeting of de novo methylation is pre-programmed by an established epigenetic system that normally has a role in marking embryonic genes for repression...
  43. ncbi Are there two sides to colorectal cancer?
    Barry Iacopetta
    Department of Surgery, University of Western Australia, Nedlands, Australia
    Int J Cancer 101:403-8. 2002
    ....
  44. pmc The chromosomal instability pathway in colon cancer
    Maria S Pino
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 138:2059-72. 2010
    ..The goal of this review is to provide an updated perspective on the mechanisms that lead to CIN and the key mutations that are acquired in this pathway...
  45. pmc MicroRNA-145 targets YES and STAT1 in colon cancer cells
    Lea H Gregersen
    Biotech Research and Innovation Centre and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e8836. 2010
    ..MicroRNAs (miRNAs) have emerged as important gene regulators and are recognized as key players in tumorigenesis. miR-145 is reported to be down-regulated in several cancers, but knowledge of its targets in colon cancer remains limited...
  46. pmc Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma
    Frank A Sinicrope
    Miles and Shirley Fiterman Digestive Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 137:1270-9. 2009
    ..We investigated whether the intratumoral densities of FoxP3(+) and effector CD3(+) lymphocytes are associated with prognosis of patients with colon cancer...
  47. ncbi Pak-1 expression increases with progression of colorectal carcinomas to metastasis
    Julia H Carter
    Wood Hudson Cancer Research Laboratory, Newport, Kentucky 41071, USA
    Clin Cancer Res 10:3448-56. 2004
    ..Because Pak-1 plays a central role in regulating cell motility and invasiveness, we sought to determine whether Pak-1 may be involved in the malignant progression of colorectal carcinoma...
  48. pmc 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
    Nasim Ahmadiyeh
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston MA 02115, USA
    Proc Natl Acad Sci U S A 107:9742-6. 2010
    ..We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC...
  49. pmc Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
    B Mann
    Department of Surgery, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    Proc Natl Acad Sci U S A 96:1603-8. 1999
    ..Together with the other alterations, beta-catenin accumulation may contribute to the development and progression of colon carcinoma both by dedifferentiation and through proteolytic activity...
  50. pmc Coaction of spheroid-derived stem-like cells and endothelial progenitor cells promotes development of colon cancer
    Bo Wei
    Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e39069. 2012
    ..Our findings indicate that spheroid cells possess the characteristics of cancer stem cells, and the coaction of CSCs and EPCs may play an important role in the development of colon cancer...
  51. ncbi Immunogenic death of colon cancer cells treated with oxaliplatin
    A Tesniere
    INSERM, U848, Villejuif, France
    Oncogene 29:482-91. 2010
    ..In conclusion, OXP induces immunogenic death of CRC cells, and this effect determines its therapeutic efficacy in CRC patients...
  52. ncbi Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089
    T E Le Voyer
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 21:2912-9. 2003
    ..To determine the relationship, in patients with adenocarcinoma of the colon, between survival and the number of lymph nodes analyzed from surgical specimens...
  53. pmc Safety of UFT/LV and S-1 as adjuvant therapy for stage III colon cancer in phase III trial: ACTS-CC trial
    I Mochizuki
    Department of Gastroenterological Surgery, Iwate Central Prefectural Hospital, 1 4 1 Ueda, Morioka, Iwate 020 0066, Japan
    Br J Cancer 106:1268-73. 2012
    ..We report the results of a planned safety analysis...
  54. ncbi Obesity-induced metabolic stresses in breast and colon cancer
    Mi Kyung Sung
    Department of Food and Nutrition, Sookmyung Women s University, Seoul, Korea
    Ann N Y Acad Sci 1229:61-8. 2011
    ..These data suggest that the metabolic burden created by excess adiposity accelerates uncontrolled cell growth and survival, thereby increasing the risk of developing breast and colon cancer...
  55. ncbi Association of the APC tumor suppressor protein with catenins
    L K Su
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 262:1734-7. 1993
    ..A 27-residue fragment of APC containing a 15-amino acid repeat was sufficient for the interaction with the catenins. These results suggest an important link between tumor initiation and cell adhesion...
  56. pmc Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells
    Tapati Mazumdar
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Cancer Res 71:5904-14. 2011
    ..Taken together, these findings establish that inhibition of HH signaling at the level of the GLI genes downstream of Smo is critical in the induction of DNA damage in early S-phase, leading to cell death in human colon carcinoma cells...
  57. ncbi Calreticulin exposure dictates the immunogenicity of cancer cell death
    Michel Obeid
    INSERM U848, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Nat Med 13:54-61. 2007
    ..These data identify CRT as a key feature determining anticancer immune responses and delineate a possible strategy for immunogenic chemotherapy...
  58. ncbi Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer
    Yixin Wang
    Veridex, LLC, a Johnson and Johnson Company, 3210 Merryfield Row, San Diego, CA 92121, USA
    J Clin Oncol 22:1564-71. 2004
    ..In this study, we used DNA chip technology to systematically identify new prognostic markers for tumor relapse in Dukes' B patients...
  59. pmc The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer
    Tapati Mazumdar
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Oncotarget 2:638-45. 2011
    ....
  60. pmc Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors
    Sudhakar Chintharlapalli
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843, USA
    BMC Cancer 11:371. 2011
    ....
  61. ncbi CD133+CD44+ population efficiently enriches colon cancer initiating cells
    Naotsugu Haraguchi
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Japan
    Ann Surg Oncol 15:2927-33. 2008
    ..In this study, we evaluated the tumorigenicity of each population of human colon cancer divided by CD133 and CD44 using non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice...
  62. pmc Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models
    Yan Ning
    Division of Medical Oncology, Sharon A Carpenter Laboratory, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA
    Int J Cancer 128:2038-49. 2011
    ..Together, these findings indicate that overexpression of IL-8 promotes tumor growth, metastasis, chemoresistance and angiogenesis, implying IL-8 to be an important therapeutic target in CRC...
  63. pmc Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
    Frédéric Varnat
    Department Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    EMBO Mol Med 1:338-51. 2009
    ..Targeting HH-GLI1, directly or indirectly, is thus predicted to decrease tumour bulk and eradicate CC stem cells and metastases...
  64. ncbi Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer
    Helen M Martin
    Department of Medicine, Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 127:80-93. 2004
    ..This study aimed to quantify and characterize mucosa-associated and intramucosal bacteria, particularly Escherichia coli, in these conditions...
  65. ncbi The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Gastroenterology 132:2208-25. 2007
    ..The mechanisms for these associations, however, remain speculative and deserve further study. Hyperinsulinemia may be important, but the role of oxidative stress initiated by hyperglycemia also deserves further attention...
  66. pmc n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon
    Laurie A Davidson
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843 2253, USA
    Carcinogenesis 30:2077-84. 2009
    ..32-fold) in adenocarcinomas. These results demonstrate for the first time the utility of the rat AOM model and the novel role of fish oil in protecting the colon from carcinogen-induced miRNA dysregulation...
  67. pmc Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB
    Chun Yan Li
    Biotherapy Center, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    J Transl Med 7:56. 2009
    ....
  68. ncbi MicroRNA-143 and -145 in colon cancer
    Yukihiro Akao
    Department of Medical Oncology, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    DNA Cell Biol 26:311-20. 2007
    ..Further, we discuss the expression of miRNA-143 and -145 in colon cancer and their roles in carcinogenesis. The available data suggest that miRNAs would be potentially useful as diagnostic and therapeutic tools...
  69. ncbi let-7 microRNA functions as a potential growth suppressor in human colon cancer cells
    Yukihiro Akao
    Department of Genetic Diagnosis, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biol Pharm Bull 29:903-6. 2006
    ..These findings suggest the involvement of let-7 miRNA in the growth of colon cancer cells. Thus, miRNAs might provide a basis for novel RNA anti-cancer agents...
  70. ncbi Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer
    Daniel G Haller
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Oncol 29:1465-71. 2011
    ..This multicenter, randomized trial compared capecitabine plus oxaliplatin (XELOX) with bolus fluorouracil (FU) and folinic acid (FA) as adjuvant therapy for patients with stage III colon cancer...
  71. pmc Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer
    Joseph E Carpentino
    McKnight Brain Institute, University of Florida, Gainesville, Florida 32609, USA
    Cancer Res 69:8208-15. 2009
    ..These data link colitis and cancer identifying potential tumor-initiating cells from colitic patients, suggesting that sphere and/or xenograft formation will be useful to survey colitic patients at risk of developing cancer...
  72. ncbi STAT3 is necessary for proliferation and survival in colon cancer-initiating cells
    Li Lin
    Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio 43205, USA
    Cancer Res 71:7226-37. 2011
    ..These findings establish a powerful rationale to develop STAT3 inhibitory strategies for treating advanced colorectal cancers...
  73. ncbi Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies
    Susanna C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Clin Nutr 86:556-65. 2007
    ..Whereas obesity has been associated with an increased risk of colon cancer in men, a weak or no association has been observed in women. Results for rectal cancer have also been inconsistent...
  74. ncbi An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
    Clemens Neufert
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    Nat Protoc 2:1998-2004. 2007
    ..Different scoring systems including number of tumors and tumor size identify factors promoting or inhibiting tumor initiation and/or tumor progression, respectively...
  75. pmc DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy
    Frank A Sinicrope
    Division of Oncology, Mayo Clinic, Rochester, MN 55905, USA
    J Natl Cancer Inst 103:863-75. 2011
    ..We determined the association of MMR status with colon cancer recurrence and examined the impact of 5-fluorouracil (FU)-based adjuvant therapy on recurrence variables...
  76. pmc EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators
    Hongyan Zhu
    Department of Medicine, University of Chicago Hospitals and Clinics, Chicago, IL 60637, USA
    Mol Cancer Res 9:960-75. 2011
    ..EGFR suppresses miR-143 and miR-145 in murine models of colon cancer. Furthermore, Western diet unmasks the tumor suppressor roles of these EGFR-regulated miRNAs...
  77. ncbi Support vector machine classification and validation of cancer tissue samples using microarray expression data
    T S Furey
    Department of Computer Science, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Bioinformatics 16:906-14. 2000
    ..This analysis consists of both classification of the tissue samples, and an exploration of the data for mis-labeled or questionable tissue results...
  78. ncbi The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer
    Ulrike Stein
    Department of Surgery and Surgical Oncology, Robert Rössle Cancer Hospital, Charite Campus Buch, Berlin, Germany
    Gastroenterology 131:1486-500. 2006
    ..Our aim was to elucidate the impact of gain-of-function beta-catenin on the metastasis-associated gene S100A4 in human colon cancer cell lines and tumors...
  79. ncbi Obesity and colon cancer: does leptin provide a link?
    Par Stattin
    Department of Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 109:149-52. 2004
    ..Leptin may be directly involved in colon tumorigenesis or it may serve as a sensitive and robust marker of an obesity-induced adverse endocrine environment. Only weak support for an association of insulin with colon cancer was found...
  80. pmc Mouse models for the study of colon carcinogenesis
    Daniel W Rosenberg
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Carcinogenesis 30:183-96. 2009
    ..We will also describe the general features of lesions formed in response to carcinogen treatment, including the underlying molecular aberrations and how these changes may relate to the pathogenesis of human colorectal cancer...
  81. ncbi Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters
    Francois Bertucci
    Département d Oncologie Moléculaire, Institut Paoli Calmettes and U119 Inserm, IFR57, Marseille, France
    Oncogene 23:1377-91. 2004
    ..These results suggest that microarrays may provide means to improve the classification of CRC, provide new potential targets against carcinogenesis and new diagnostic and/or prognostic markers and therapeutic targets...
  82. ncbi Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor γ
    Tamotsu Tsukahara
    Department of Integrative Physiology and Bio System Control, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Nagano, Japan
    Prostaglandins Other Lipid Mediat 93:126-33. 2010
    ..Our results identify PPARγ as a molecular mediator of cPA activity in HT-29 cells, and suggest that cPA and the PPARγ pathway might be therapeutic targets in the treatment of colon cancer...
  83. ncbi beta-catenin destruction complex: insights and questions from a structural perspective
    D Kimelman
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Oncogene 25:7482-91. 2006
    ....
  84. ncbi Oncologic results of laparoscopic versus conventional open surgery for stage II or III left-sided colon cancers: a randomized controlled trial
    Jin Tung Liang
    Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    Ann Surg Oncol 14:109-17. 2007
    ..However, the oncologic outcome for cancer is still a concern. This study aims to compare the oncologic outcome between laparoscopic and open methods in the curative resection of Stage II or III left-sided colon cancers...
  85. pmc Multistage carcinogenesis and the incidence of colorectal cancer
    E Georg Luebeck
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P O Box 19024, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 99:15095-100. 2002
    ..By contrast, interventions that decrease the rate of mutations at the adenomatous polyposis coli locus are much less effective in reducing the risk of colon cancer...
  86. ncbi Colonoscopic withdrawal times and adenoma detection during screening colonoscopy
    Robert L Barclay
    Rockford Gastroenterology Associates, IL 61107, USA
    N Engl J Med 355:2533-41. 2006
    ....
  87. pmc miRNA expression in colon polyps provides evidence for a multihit model of colon cancer
    Ann L Oberg
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e20465. 2011
    ..The comparison between pMMR and dMMR tumors identified four miRNAs (miR-31, miR-552, miR-592 and miR-224) with statistically significant expression differences (≥2-fold change)...
  88. ncbi Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial
    Ruben Veldkamp
    Erasmus Medical Center, Rotterdam, Netherlands
    Lancet Oncol 6:477-84. 2005
    ....
  89. ncbi Lymph node evaluation and survival after curative resection of colon cancer: systematic review
    George J Chang
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Blvd, Unit 444, Houston, TX 77030, USA
    J Natl Cancer Inst 99:433-41. 2007
    ..We performed a systematic review of the evidence for the association between lymph node evaluation and oncologic outcomes in patients with colon cancer...
  90. pmc Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer
    Weidong Zhao
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 23:395-402. 2004
    ..These findings indicate that KLF4 is a potential tumor suppressor gene in CRC...
  91. pmc Hedgehog signaling drives cellular survival in human colon carcinoma cells
    Tapati Mazumdar
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Cancer Res 71:1092-102. 2011
    ..Collectively, these results highlight the importance of Gli activation downstream of Smo as a therapeutic target in models of human colon carcinoma...
  92. pmc Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin
    MICHAEL J O'CONNELL
    National Surgical Adjuvant Breast and Bowel Project, University of Pittsburgh, Pittsburgh, PA 15212, USA
    J Clin Oncol 28:3937-44. 2010
    ....
  93. ncbi The prevalence of PIK3CA mutations in gastric and colon cancer
    Sergia Velho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Portugal
    Eur J Cancer 41:1649-54. 2005
    ..016). In colorectal carcinoma, PIK3CA mutations occur preferentially together with activating KRAS-BRAF mutations (MSI and MSS) while in gastric carcinomas PIK3CA mutations tend to occur as isolated events (MSI)...
  94. ncbi Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway
    Gaspare La Rocca
    Department of Cancer Biology at Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA 19107, USA
    J Cell Physiol 220:485-91. 2009
    ..These and other results, taken together, indicate that down-regulation of IRS-1 plays a significant role in the tumor suppressor activity of miR145...
  95. ncbi MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells
    Antonio Strillacci
    Department of Experimental Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Exp Cell Res 315:1439-47. 2009
    ..An impairment of miR-101 levels could represent one of the leading causes of COX-2 overexpression in colon cancer cells...
  96. pmc The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer
    Qiang Zhou
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, 651 Dongfeng R E, 510060, Guangzhou, China
    J Transl Med 8:13. 2010
    ..This study examined whether TAMs are involved in hepatic metastasis of colon cancer...
  97. pmc Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer
    Amy J French
    Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, 920 Hilton Building, Rochester, MN 55905, USA
    Clin Cancer Res 14:3408-15. 2008
    ..Although the presence of dMMR seems to be a favorable prognostic marker, data suggest that these patients do not respond as well to adjuvant chemotherapy...
  98. ncbi Curcumin for chemoprevention of colon cancer
    Jeremy James Johnson
    University of Wisconsin, School of Pharmacy, 777 Highland Avenue, Madison, WI 53705 2222, USA
    Cancer Lett 255:170-81. 2007
    ..This review will focus on describing the pre-clinical and clinical evidence of curcumin as a chemopreventive compound in colorectal cancer...
  99. ncbi A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293
    Cancer Sci 94:965-73. 2003
    ..At week 20, colonic neoplasms (adenocarcinomas, 100% incidence with 5.60 +/- 2.42 multiplicity; and adenomas, 38% incidence with 0...
  100. pmc Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer
    Harold L Newmark
    Department of Chemical Biology, Laboratory for Cancer Research, Rutgers University, Piscataway, NJ 08854, USA
    Carcinogenesis 30:88-92. 2009
    ....
  101. ncbi Improving staging accuracy in colon and rectal cancer by sentinel lymph node mapping: a comparative study
    E S van der Zaag
    Department of Surgery, Gelre Ziekenhuizen, Albert Schweitzerlaan 31, 7334 DZ Apeldoorn, The Netherlands
    Eur J Surg Oncol 35:1065-70. 2009
    ..To compare the predictive value of sentinel lymph node (SN) mapping between patients with colon and rectal cancer...

Research Grants62

  1. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013
    ..Information gleaned from our research may open up new strategies for prevention and clinical management of prostate cancer. ..
  2. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    ..Current studies could facilitate the development of therapy for mucus hypersecretory diseases through identification of small carbohydrate inhibitors and mucus cell-specific promoter. ..
  3. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ....
  4. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O'KEEFE; Fiscal Year: 2012
    ..Our previous studies have suggested the difference can be attributed to the relatively higher meat and animal fat intake by African Americans and the higher resistant starch intake by Africans. ..
  5. DNA Methyltrasferase Gene Expression in Colon Cancer
    Stephen B Baylin; Fiscal Year: 2013
    ..Reactivation of these genes holds promise for constructing prevention and treatment strategies for this disease. ..
  6. Mechanisms of CDX2 regulation of the IGF axis
    Duyen Dang; Fiscal Year: 2013
    ..As such, studying how CDX2 functions would provide insights into the development and progression of colonic neoplasms. This proposal advances on the concept that CDX2 regulates the IGF axis, depending on cellular p53 status...
  7. Regulation of Lipid Droplets and FOXO3 in Intestinal Epithelial Cell Proliferatio
    SUZANA SAVKOVIC; Fiscal Year: 2013
    ..Although mechanisms of colon cancer progression are complex, the inhibition of LDs may provide an effective blockade to tumor progression in patients with obesity promoted colonic tumor progression. ..
  8. The relationship between epidermal growth factor receptor and hedgehog signaling
    Robert B Rebhun; Fiscal Year: 2011
    ..The goal of this project is to understand and describe interactions between specific cell signaling pathways that have individually been implicated in the progression of colon cancer. ..
  9. The relationship between epidermal growth factor receptor and hedgehog signaling
    Robert B Rebhun; Fiscal Year: 2013
    ..Dr. Rebhun is a board certified clinical veterinary oncologist (DVM, Diplomate ACVIM-Oncology) and is a dual-trained clinician/scientist with a Ph.D. degree in cancer biology. Five years of mentored support is requested. ..
  10. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    FRANCIS GERARD BLANKENBERG; Fiscal Year: 2010
    ..Successful completion of our proposal will give the needed preclinical data for pursuing scVEGF targeted radiotherapy in other models and ultimately clinical applications. ..
  11. Defining the promoting effect of folate on colorectal cancer in a novel animal mo
    Joel B Mason; Fiscal Year: 2012
    ..This novel animal model of colorectal carcinogenesis, GEM-1, allows one to monitor development of colonic neoplasms in vivo over a period of several months...
  12. EDRN: Clinical Epidemiology & Validation Centers
    Henry T Lynch; Fiscal Year: 2010
    ..b. a study to evaluate the acceptability of hypothetical biomarkers among high risk and average risk individuals and primary health care providers. ..
  13. Dual-energy Electronic-cleansing CT Colonography for Colon Cancer Screening
    Hiroyuki Yoshida; Fiscal Year: 2013
    ..Thus, the proposed research will substantially raise the screening rate and the early detection of colonic polyps and cancers. ..
  14. Combined Chemoprevention in Beta-Catenin Mutant Mice
    Gayle Orner; Fiscal Year: 2004
    ....
  15. Combined effects of tea plus NSAIDS towards colon cancer
    Gayle Orner; Fiscal Year: 2004
    ..abstract_text> ..
  16. CALCIUM AND COLORECTAL EPITHELIAL CELL PROLIFERATION
    John Potter; Fiscal Year: 1992
    ....
  17. Targeted delivery of butyrate to the colon in mice
    SHARON FLEMING; Fiscal Year: 2006
    ..These results will inform applications for treatment and prevention of disease in humans. ..
  18. THE MOLECULAR BASIS OF AXIS FORMATION IN XENOPUS
    Janet Heasman; Fiscal Year: 2005
    ..This understanding is a prerequisite for the design of strategies for therapeutic interference with this pathway in anticancer treatment. ..
  19. RELATIONSHIPS OF FECAL MUTAGENS TO COLON CANCER
    Tracy Wilkins; Fiscal Year: 1992
    ..A decrease in their concentrations then could predispose a person to colonic cancer...
  20. GROWTH REGULATION OF HUMAN COLONIC NEOPLASMS
    Michael Brattain; Fiscal Year: 1991
    ....
  21. GENETIC DETERMINATES OF HUMAN COLON NEOPLASIA
    Georgia Wiesner; Fiscal Year: 2003
    ..To employ a set of 350 polymorphic markers to conduct a complete scan of the genome to identify new genes that are associated with susceptibility for cancer or colon polyps in these sibships. ..
  22. The role of glutathione peroxidase in the pathogenesis of intestinal cancer
    Fong Fong Chu; Fiscal Year: 2010
    ..About a million Americans suffer IBD, and have higher risks for cancer. Study of this novel mouse IBD model may provide new information on the etiology and treatment of IBD and IBD-related cancer. ..
  23. SELECTIVE RADIOIMMUNOTHERAPY OF COLON CANCER
    David Goldenberg; Fiscal Year: 1980
    ..This study should serve as a basis for possible later clinical trials...
  24. Aging and Cancer of the Colon
    STEVEN DUDAS; Fiscal Year: 2004
    ..To our knowledge, this is the first study that proposes to examine these aspects in archival colon cancer specimens in relationship to age. ..
  25. COTTON-TOP TAMARIN MODEL FOR STUDIES OF COLITIS & CANCER
    Daniel Podolsky; Fiscal Year: 1991
    ....
  26. Mechanisms of ultrasound mediated intracellular drug and gene delivery
    Cheri Deng; Fiscal Year: 2009
    ..abstract_text> ..
  27. EVALUATION OF CLINICAL OUTCOMES IN SMALL AREAS OF MICH
    LAURENCE MC MAHON; Fiscal Year: 1991
    ....
  28. Obesity, hyperinsulinemia and colon cancer
    SHARON FLEMING; Fiscal Year: 2003
    ..These studies will provide new knowledge that will be used to support a follow-up R01 application. ..
  29. NUCLEOSIDE TRANSPORTERS--STRUCTURE/FUNCTION AND REGULATI
    Chung Ming Tse; Fiscal Year: 2004
    ..abstract_text> ..
  30. BETA-CATENIN AND RAR INTERACT AT THE PKC ALPHA PROMOTER
    Frank Sinicrope; Fiscal Year: 2002
    ..abstract_text> ..
  31. MASS SPECTROMETRY OF URINARY NUCLEOSIDES
    Karl Schram; Fiscal Year: 1991
    ....
  32. BREAST CANCER
    THOMAS PRETLOW; Fiscal Year: 1980
    ....
  33. GENES, ANTICARCINOGENS AND COLON NEOPLASMS
    Henry Lin; Fiscal Year: 2006
    ..Results may lead to better understanding of protective mechanisms involving aspirin and nonsteroidal anti-inflammatory drugs. ..
  34. CHANGES IN MOUSE COLON DURING CHEMICAL CARCINOGENESIS
    Thomas Richards; Fiscal Year: 1980
    ..Documentation of preneoplastic changes, evoked in crypt glands of the colon, during treatment with DMH, will provide clues to the underlying processes of tumor formation. ..
  35. RAT INTESTINAL MEMBRANE--VITAMIN D-MEDIATED EFFECTS
    Michael Sitrin; Fiscal Year: 2001
    ..Accordingly the specific aims of the proposal are to characterize the mechanisms involved in inhibition of cellular proliferation in CaCo-2 cells and the actions of the secosteroids in inducing apoptosis. ..
  36. Isolated Hepatic Perfusion with Oxaliplatin
    David Bartlett; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  37. Inhibiting Survivin for Chemoprevention of Colon Cancer
    SERGIO LAMPRECHT; Fiscal Year: 2005
    ..abstract_text> ..
  38. A MODEL FOR COLONIC CANCER-ASSOCIATED ANTIGENS
    KESHAB PANT; Fiscal Year: 1980
    ..We are also interested in the growth behavior and phenotypic expression of colonic carcinomas and polyps in hamsters and nude mice. ..
  39. METABOLIC EPIDEMIOLOGY OF COLON CANCER
    Bandaru Reddy; Fiscal Year: 1980
    ..In addition, we propose to isolate and identify the mutagens (presumptive carcinogens) in the feces of above study populations. ..
  40. Dock and Lock: novel protein engineering
    Chien Hsing Chang; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  41. Network for Translational Research: Optical Imaging
    Wafik El Deiry; Fiscal Year: 2007
    ..The experimental plan is highly translational with specific goals in mind including early detection of colonic neoplasms, early detection of lymphatic spread, non-invasive imaging of angiogenesis and its correlates hypoxia, ..
  42. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  43. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  44. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  45. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  46. Clinical Significance of Apoptosis in Colon Cancer
    Frank Sinicrope; Fiscal Year: 2006
    ..abstract_text> ..
  47. Aberrant Crypt Foci as a Biomarker for Chemoprevention
    Frank Sinicrope; Fiscal Year: 2009
    ....
  48. PROINHIBITORS OF CHEMICAL CARCINOGENESIS
    LUKE LAM; Fiscal Year: 1991
    ..The mortality rate due to colorectal cancer in the United States is second only to lung cancer. This study uses the proinhibitors concept to design agents that are aimed to prevent cancer of the colon...
  49. WEIGHT LOSS IN OBESE BREAST CANCER SURVIVORS
    Zora Djuric; Fiscal Year: 2002
    ..This study should be useful to determine certain psychosocial are associated with extent of weight loss, and in turn whether weight loss is associated with changes in selected markers of breast cancer risk. ..
  50. DIETARY INTERVENTION--WOMEN HIGH RISK FOR BREAST CANCER
    Zora Djuric; Fiscal Year: 2002
    ..The use of biomarkers will allow to evaluate the cancer-protective effects of dietary modulation over a relatively short period of time. ..
  51. METHODOLOGIC ISSUES IN NUTRITIONAL EPIDEMIOLOGY
    KARIN MICHELS; Fiscal Year: 2002
    ..We aim to provide guidance to researchers who wish to explore diet-disease relations in how to use data best to obtain most valid results and avoid pitfalls which might produce misleading associations. ..
  52. LEPTIN, IGFS AND COLORECTAL ADENOMA CANCER RISK
    Polly Newcomb; Fiscal Year: 2005
    ..This study may provide insights into the biologic mechanisms whereby obesity is associated with colorectal cancer risk, as well as have practical implications for cancer prevention. ..
  53. Hormones and Colon Cancer: Epigenetic Subtypes, Risk, and Survival
    Polly Newcomb; Fiscal Year: 2009
    ....
  54. Bispecific Antibody Pretargeted Therapy of Pancreatic Cancer
    ROBERT SHARKEY; Fiscal Year: 2008
    ..Overall, these studies will assist in establishing whether this type of pretargeting approach could have a role in the clinical management of pancreatic cancer. [unreadable] [unreadable] [unreadable]..
  55. Improved Detection of Cancer Using Bi Specific Antibody
    ROBERT SHARKEY; Fiscal Year: 2003
    ....