gallbladder neoplasms

Summary

Summary: Tumors or cancer of the gallbladder.

Top Publications

  1. ncbi Diagnosis of gallbladder tumors
    Kazuo Inui
    Department of Internal Medicine, Second Teaching Hospital, Fujita Health University, Japan
    Intern Med 50:1133-6. 2011
  2. ncbi Epidemiology and molecular pathology of gallbladder cancer
    E C Lazcano-Ponce
    Epidemiology Department, Population Health Research Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico
    CA Cancer J Clin 51:349-64. 2001
  3. ncbi Epidemiology and risk factors for gallstone disease: has the paradigm changed in the 21st century?
    Eldon A Shaffer
    Faculty of Medicine, GI Division, University of Calgary, Canada
    Curr Gastroenterol Rep 7:132-40. 2005
  4. ncbi Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma
    Dong Cai Liu
    Department of Geriatric Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Cancer Biomark 8:113-21. 2010
  5. ncbi Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas
    S Rau
    University of Heidelberg, Heidelberg, Germany
    Eur J Clin Invest 38:134-42. 2008
  6. ncbi Differential diagnostic and staging accuracies of high resolution ultrasonography, endoscopic ultrasonography, and multidetector computed tomography for gallbladder polypoid lesions and gallbladder cancer
    Jin Young Jang
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    Ann Surg 250:943-9. 2009
  7. ncbi Palliative and postoperative radiotherapy in biliary tract cancer
    O Kenneth Macdonald
    University of Texas at Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Surg Oncol Clin N Am 11:941-54. 2002
  8. ncbi Height and body mass index in relation to colorectal and gallbladder cancer in two million Norwegian men and women
    Anders Engeland
    Division of Epidemiology, Norwegian Institute of Public Health, P O Box 4404, N 0403 Nydalen, Oslo, Norway
    Cancer Causes Control 16:987-96. 2005
  9. pmc Clinicopathologic features of polypoid lesions of the gallbladder and risk factors of gallbladder cancer
    Wooil Kwon
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 24:481-7. 2009
  10. ncbi Risk factors influencing recurrence, patterns of recurrence, and the efficacy of adjuvant therapy after radical resection for gallbladder carcinoma
    Woo Seok Kim
    Department of Surgery, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea
    J Gastrointest Surg 14:679-87. 2010

Detail Information

Publications276 found, 100 shown here

  1. ncbi Diagnosis of gallbladder tumors
    Kazuo Inui
    Department of Internal Medicine, Second Teaching Hospital, Fujita Health University, Japan
    Intern Med 50:1133-6. 2011
    ..5%). Serial observation in patients with gallstones and prophylactic surgery in patients with abnormal connections between pancreatobiliary ducts are necessary...
  2. ncbi Epidemiology and molecular pathology of gallbladder cancer
    E C Lazcano-Ponce
    Epidemiology Department, Population Health Research Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico
    CA Cancer J Clin 51:349-64. 2001
    ..Secondary prevention of gallbladder cancer could be effective if supported by cost-effective studies of prophylactic cholecystectomy among asymptomatic gallstone patients in high-risk areas...
  3. ncbi Epidemiology and risk factors for gallstone disease: has the paradigm changed in the 21st century?
    Eldon A Shaffer
    Faculty of Medicine, GI Division, University of Calgary, Canada
    Curr Gastroenterol Rep 7:132-40. 2005
    ..Our abundant access to food places us at the increased risk of obesity and cholelithiasis. The general rise in obesity in many countries raises the specter of heightened disease, best identified by epidemiologic studies...
  4. ncbi Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma
    Dong Cai Liu
    Department of Geriatric Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Cancer Biomark 8:113-21. 2010
    ..Our study suggested that Msi-1 and/or ALDH1 expression might be closely related to the carcinogenesis, progression, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma...
  5. ncbi Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas
    S Rau
    University of Heidelberg, Heidelberg, Germany
    Eur J Clin Invest 38:134-42. 2008
    ..To further define the role of MRP family members in biliary tract cancer, we studied the expression and localization of MRP2 and MRP3 in cholangiocellular carcinomas and gallbladder carcinomas...
  6. ncbi Differential diagnostic and staging accuracies of high resolution ultrasonography, endoscopic ultrasonography, and multidetector computed tomography for gallbladder polypoid lesions and gallbladder cancer
    Jin Young Jang
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    Ann Surg 250:943-9. 2009
    ....
  7. ncbi Palliative and postoperative radiotherapy in biliary tract cancer
    O Kenneth Macdonald
    University of Texas at Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Surg Oncol Clin N Am 11:941-54. 2002
    ..Novel approaches, including neoadjuvant chemoradiotherapy combined with OLT, and escalated conformal irradiation, seem to be promising and warrant further investigation...
  8. ncbi Height and body mass index in relation to colorectal and gallbladder cancer in two million Norwegian men and women
    Anders Engeland
    Division of Epidemiology, Norwegian Institute of Public Health, P O Box 4404, N 0403 Nydalen, Oslo, Norway
    Cancer Causes Control 16:987-96. 2005
    ..The present study aimed at exploring the relations between BMI and stature and colorectal and gallbladder cancer in a huge Norwegian cohort with measured height and weight...
  9. pmc Clinicopathologic features of polypoid lesions of the gallbladder and risk factors of gallbladder cancer
    Wooil Kwon
    Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 24:481-7. 2009
    ..87) were identified as risk factors for malignant PLG. Careful decision making on therapeutic plans should be made with consideration of malignancy for patients over 60 yr, with sessile morphology of PLG, and with PLG size of over 10 mm...
  10. ncbi Risk factors influencing recurrence, patterns of recurrence, and the efficacy of adjuvant therapy after radical resection for gallbladder carcinoma
    Woo Seok Kim
    Department of Surgery, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea
    J Gastrointest Surg 14:679-87. 2010
    ..The aim of this study was to characterize patterns of recurrence and to identify the factors that influence recurrence and the efficacy of adjuvant therapy after the curative resection of GBC...
  11. ncbi hOGG1 Ser326Cys polymorphism and susceptibility to gallbladder cancer in a Chinese population
    Xingyuan Jiao
    Department of Hepatobiliary Surgery, Second Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong Province, The People s Republic of China
    Int J Cancer 121:501-5. 2007
    ..2, 95% CI = 0.8-4.0; hOGG1 326Cys/Cys:OR = 2.9, 95% CI = 0.6-29.4; p = 0.06, chi(2) tread test). These results suggest that hOGG1 Ser326Cys polymorphism is associated with gallbladder cancer risk...
  12. ncbi Gallbladder cancer
    Stavros Gourgiotis
    Second Surgical Department, 401 General Army Hospital of Athens, Athens, Greece
    Am J Surg 196:252-64. 2008
    ..Gallbladder cancer (GC) is a relatively rare but highly lethal neoplasm. We review the epidemiology, etiology, pathology, symptoms, diagnosis, staging, treatment, and prognosis of GC...
  13. ncbi Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1
    Jian Wei Wang
    Department of Surgery, Second Affiliated Hospital, Zhejiang University, Hangzhou, China
    Cancer Lett 281:71-81. 2009
    ....
  14. pmc Current management of gallbladder carcinoma
    Andrew X Zhu
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
    Oncologist 15:168-81. 2010
    ..Molecularly targeted agents are under development. In this review, we attempt to discuss the current status and key issues involved in the management of GBC...
  15. ncbi Significant association between toll-like receptor gene polymorphisms and gallbladder cancer
    Kshitij Srivastava
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Liver Int 30:1067-72. 2010
    ..The present study was undertaken to examine the potential association of two polymorphisms in TLR2 and TLR4 genes with gallbladder cancer (GBC) susceptibility...
  16. ncbi Overexpression of LAPTM4B-35 closely correlated with clinicopathological features and post-resectional survival of gallbladder carcinoma
    Li Zhou
    Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100032, China
    Eur J Cancer 43:809-15. 2007
    ..004 and 0.027, respectively). LAPTM4B-35 overexpressed in a majority of GBCs and correlated with clinicopathological features and post-resectional survival...
  17. ncbi Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC-2009 study group
    J M Regimbeau
    Department of Digestive Surgery, Amiens North Hospital, University of Picardy Medical Centre, Place Victor Pauchet, Amiens Cedex 01, France
    Eur J Surg Oncol 37:505-12. 2011
    ..The present study was designed to re-assess the prognostic value of jaundice in patients with GBC...
  18. ncbi Radiologic diagnosis of adenomyomatosis of the gallbladder: comparative study among MRI, helical CT, and transabdominal US
    K Yoshimitsu
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Comput Assist Tomogr 25:843-50. 2001
    ..The goal of this work was to evaluate the diagnostic accuracy of transabdominal ultrasound (US), helical CT, and MRI in the diagnosis of adenomyomatosis (ADM) of the gallbladder...
  19. ncbi Diagnosis and surgical management of gallbladder cancer: a review
    Kaye M Reid
    Department of Surgery, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    J Gastrointest Surg 11:671-81. 2007
    ..Current trials are investigating the role of capecitabine, oxaliplatin, and bevacizumab in the management of gallbladder carcinoma...
  20. ncbi Imaging of adenomyomatosis of the gall bladder
    H Stunell
    Department of Radiology, Adelaide and Meath Hospital, Dublin, Ireland
    J Med Imaging Radiat Oncol 52:109-17. 2008
    ..A brief section on oral cholecystography to aid readers familiar with this technique in understanding the comparable imaging features on more modern imaging techniques is included...
  21. ncbi CT differentiation of adenomyomatosis and gallbladder cancer
    Brian H Ching
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Box 0628, Room M372, San Francisco, CA 94143 0628, USA
    AJR Am J Roentgenol 189:62-6. 2007
    ..The purpose of this study was to determine the accuracy of CT in differentiating adenomyomatosis from gallbladder cancer...
  22. pmc Significant role of estrogen and progesterone receptor sequence variants in gallbladder cancer predisposition: a multi-analytical strategy
    Anshika Srivastava
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    PLoS ONE 7:e40162. 2012
    ..Therefore the present study was designed to explore the role of genetic variants in estrogen (ESR1, ESR2) and progesterone (PGR) receptors in conferring risk of gallbladder cancer...
  23. ncbi Factors influencing postoperative hospital mortality and long-term survival after radical resection for stage IV gallbladder carcinoma
    Satoshi Kondo
    First Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, 466 8550, Showa Ku, Nagoya, Japan
    World J Surg 27:272-7. 2003
    ..Better patient selection may improve the outcome of radical surgery for stage IV gallbladder carcinoma. These data may be useful in designing future trials of the surgical treatment of advanced gallbladder carcinoma...
  24. ncbi Epidemiology of biliary tract cancers: an update
    G Randi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Ann Oncol 20:146-59. 2009
    ..Biliary tract cancer (BTC) is a rare cancer in Europe and North America, characterized by wide geographic variation, with high incidence in some areas of Latin America and Asia...
  25. ncbi Helical CT of the local spread of carcinoma of the gallbladder: evaluation according to the TNM system in patients who underwent surgical resection
    Kengo Yoshimitsu
    Department of Clinical Radiology, Kyushu University Graduate School of Medical Sciences, 3 1 1, Maidashi, Higashi ku Fukuoka 812 8582, Japan
    AJR Am J Roentgenol 179:423-8. 2002
    ..Our aim was to evaluate the performance of helical CT as an aid in the preoperative diagnosis of the spread of carcinomas of the gallbladder...
  26. ncbi Extended right hemihepatectomy for gallbladder carcinoma involving the hepatic hilum
    K Shimada
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Centre Hospital, Tokyo, Japan
    Br J Surg 98:117-23. 2011
    ..Major hemihepatectomy for advanced gallbladder carcinoma remains controversial as it is associated with serious postoperative complications and poor prognosis...
  27. ncbi Gallbladder and biliary tract carcinoma: A comprehensive update, Part 2
    William P Daines
    Harvard University, Boston, Massachusetts, USA
    Oncology (Williston Park) 18:1049-59; discussion 1060, 1065-6, 1068. 2004
    ..These strategies are of relevance to internists as well as oncologists caring for these patients...
  28. ncbi A review of the surgical strategies for the management of gallbladder carcinoma based on T stage and growth type of the tumour
    C Pilgrim
    The Alfred Hospital, Upper Gastrointestinal Surgery, Commercial Rd, Melbourne, VIC 3000, Australia
    Eur J Surg Oncol 35:903-7. 2009
    ..The extent of resection varies based on a number of factors, and controversy exists regarding what constitutes an acceptable resection. A review of current recommendations and practice was undertaken...
  29. ncbi Expression of oncogene products and growth factors in early gallbladder cancer, advanced gallbladder cancer, and chronic cholecystitis
    M Yukawa
    Department of Pathology, Kobe University School of Medicine, Japan
    Hum Pathol 24:37-40. 1993
    ..These results suggest that various oncogenes may have significant roles in gallbladder cancer and that collagen synthesis is reduced by epidermal growth factor and enhanced by transforming growth factor-beta...
  30. ncbi Incidence, management, and outcome of incidental gallbladder carcinoma: analysis of the database of the Swiss association of laparoscopic and thoracoscopic surgery
    Philippe Marc Glauser
    Department of Surgery, Hospital of Liestal, 4410, Liestal, Switzerland
    Surg Endosc 24:2281-6. 2010
    ..We present the long-term survival and the results of re-resection versus simple cholecystectomy of the database of the Swiss Association for Laparoscopic and Thoracoscopic Surgery (SALTS) from 1994 to 2004...
  31. ncbi Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma
    Tadahiro Takada
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Cancer 95:1685-95. 2002
    ....
  32. ncbi Chemotherapy in the treatment of advanced gallbladder cancer
    Hiroshi Ishii
    Division of Hepatobiliary and Pancreatic Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Oncology 66:138-42. 2004
    ..To clarify the role of chemotherapy for advanced gallbladder cancer (GBC)...
  33. ncbi Expression of LAPTM4B in gallbladder carcinoma cells: the role in invasive potential
    Li Zhou
    Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100730, China
    Hepatogastroenterology 57:207-11. 2010
    ..However, expression of LAPTM4B gene in gallbladder carcinoma (GBC-SD), a gallbladder carcinoma cell line, and its role in invasive potential remain unclear...
  34. pmc Carcinoma involving the gallbladder: a retrospective review of 23 cases - pitfalls in diagnosis of gallbladder carcinoma
    Tran H Giang
    University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Diagn Pathol 7:10. 2012
    ..Despite the frequency of cholecystectomy, diagnosis of GBC remains problematic in many situations. We sought to identify pathologic features that contribute to the difficulty in recognition of GBC...
  35. ncbi Benefits of reoperation of T2 and more advanced incidental gallbladder carcinoma: analysis of the German registry
    Thorsten Oliver Goetze
    Department of Surgery, Ketteler Krankenhaus, Offenbach, Germany
    Ann Surg 247:104-8. 2008
    ..The aim of this study was to determine which T stages of incidental gallbladder carcinoma (IGBC) actually benefit from an early reresection (ERR)...
  36. pmc Geographic variation of gallbladder cancer mortality and risk factors in Chile: a population-based ecologic study
    Marcelo E Andia
    Departamento de Salud Publica, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Int J Cancer 123:1411-6. 2008
    ..7). Our results suggest that gallbladder cancer in Chile may be related to both genetic factors and poor living conditions. Future analytic studies are needed to further clarify the role of these factors in gallbladder cancer etiology...
  37. ncbi Radical lymph node dissection for gallbladder cancer: indications and limitations
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Japan
    Surg Oncol Clin N Am 16:221-32. 2007
    ..Extended resection with extensive lymphadenectomy should be limited to expert surgeons because it may cause serious morbidity and mortality...
  38. ncbi Significance of extensive surgery including resection of the pancreas head for the treatment of gallbladder cancer--from the perspective of mode of lymph node involvement and surgical outcome
    Ryoko Sasaki
    Department of Surgery I, Iwate Medical University, 19 1 Uchimaru, Morioka, 020 8505, Japan
    World J Surg 30:36-42. 2006
    ..Pancreatoduodenectomy combined with S4aS5 hepatic subsegmentectomy should be considered when lymph node metastasis is obvious and the patient is in good condition...
  39. ncbi Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: an immunohistochemical and in situ hybridization study
    T Yamato
    Department of Pathology II, Kanazawa University School of Medicine, Kanazawa 920, Japan
    J Pathol 188:30-7. 1999
    ....
  40. ncbi New prognostic factor influencing long-term survival of patients with advanced gallbladder carcinoma
    Fumihiko Miura
    Department of Surgery, Teikyo University School of Medicine, Itabashi ku, Tokyo, Japan
    Surgery 148:271-7. 2010
    ..In this study, a newly formulated original stage classification of advanced GBC was evaluated to clarify prognostic factors affecting long-term survival...
  41. ncbi An immunohistochemical study of the expression of adhesion molecules in gallbladder lesions
    Yoon La Choi
    Department of Pathology, Samsung Medical Center, Sungkyunkwan University, College of Medicine, Seoul, Korea
    J Histochem Cytochem 52:591-601. 2004
    ..05). These results suggest that altered expression of these adhesion molecules is involved in the progression and metastasis of gallbladder carcinomas...
  42. ncbi Gallbladder cancer: can newer insights improve the outcome?
    Usha Dutta
    Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Gastroenterol Hepatol 27:642-53. 2012
    ....
  43. ncbi Prediction of prognosis in gallbladder carcinoma by mucin and p53 immunohistochemistry
    Mayuko Takagawa
    Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine, Tokushima City, Japan
    Dig Dis Sci 50:1410-3. 2005
    ....
  44. pmc Estrogen-dependent gallbladder carcinogenesis in LXRbeta-/- female mice
    Chiara Gabbi
    Department of Biosciences and Nutrition, Karolinska Institutet, S 141 86 Novum, Sweden
    Proc Natl Acad Sci U S A 107:14763-8. 2010
    ..These findings suggest that LXRbeta in a complex interplay with estrogens and TGF-beta could play a crucial role in the malignant transformation of the gallbladder epithelium...
  45. ncbi Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas
    Hee Jin Chang
    Research Institute and Hospital, National Cancer Center, Seoul, Korea
    Pathol Oncol Res 13:326-35. 2007
    ..009). Thus, PML and p53 are potential candidates for development as clinically applicable molecular prognostic markers of GBC, and may be effective therapeutic targets for the disease in the future...
  46. ncbi Wall-invasion pattern correlates with survival of patients with gallbladder adenocarcinoma
    Ken Ichi Okada
    Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Anticancer Res 29:685-91. 2009
    ..039-0.629) was an independent predictor of mortality. In conclusion, the DG invasion pattern is an indicator of high malignant potential and indirectly worsens the prognosis of patients with gallbladder adenocarcinoma...
  47. ncbi Gallbladder carcinoma update: multimodality imaging evaluation, staging, and treatment options
    Alessandro Furlan
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian Campus, 200 Lothrop St, Rm 3950 CHP MT, Pittsburgh, PA 15213, USA
    AJR Am J Roentgenol 191:1440-7. 2008
    ..The purpose of this article is to review the epidemiology, multimodality imaging findings, differential diagnosis, pathologic staging, and current treatment options of gallbladder carcinoma...
  48. pmc Renal cell carcinoma with metastases to the gallbladder: four cases from the National Cancer Institute (NCI) and review of the literature
    Paul H Chung
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Urol Oncol 30:476-81. 2012
    ..We evaluate presentation and outcome of patients with metastatic RCC to the gallbladder from our institution and published literature...
  49. pmc Gallbladder cancer predisposition: a multigenic approach to DNA-repair, apoptotic and inflammatory pathway genes
    Kshitij Srivastava
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    PLoS ONE 6:e16449. 2011
    ..In conclusion, the present multigenic approach can be used to define individual risk profiles for gallbladder cancer in North Indian population...
  50. ncbi MUC 1 core protein as a marker of gallbladder malignancy
    M Ghosh
    Department of Gastroenterological and Hepatobiliary Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba Shi 305, Japan
    Eur J Surg Oncol 31:891-6. 2005
    ..The significance of MUC 1 expression in the gallbladder tissues in relation to cancer and non-cancer disease is not well understood. The aim of this study was to clarify the significance of MUC 1 expression...
  51. ncbi Polymorphisms in ERCC2, MSH2, and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India
    Kshitij Srivastava
    Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Cancer 116:3160-9. 2010
    ..Genetic variants of DNA repair enzymes may lead to genetic instability and contribute to gallbladder (GB) carcinogenesis...
  52. ncbi Hepatoid adenocarcinoma of the gallbladder: Case report and review of the literature
    Kazuhiro Sakamoto
    Department of Pathology, Tohoku University Hospital, Sendai, Japan
    Pathol Int 54:52-6. 2004
    ..Based on these findings, this case was diagnosed as hepatoid adenocarcinoma of the gallbladder, which is generally a vary rare neoplasm in the literature, but should be included in the differential diagnosis of a mass in the gallbladder...
  53. ncbi Hepatoid adenocarcinoma of the gallbladder
    H Gakiopoulou
    a Department of Pathology, Medical School, The National and Kapodistrian University of Athens, Athens, Greece
    Dig Dis Sci 52:3358-62. 2007
  54. ncbi An analysis of rare carcinoid tumors: clarifying these clinical conundrums
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, 333 Cedar Street, P O Box 208062, New Haven, CT 06520 8062, USA
    World J Surg 29:92-101. 2005
    ..Familiarity with such unusual sites of origin will facilitate appropriate recognition and characterization of such tumors, allowing for timely intervention...
  55. ncbi Single-nucleotide polymorphisms of DNA repair genes OGG1 and XRCC1: association with gallbladder cancer in North Indian population
    Anvesha Srivastava
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India
    Ann Surg Oncol 16:1695-703. 2009
    ..This study was aimed to examine the role of OGG1 Ser326Cys (rs1052133) and XRCC1 Arg194Trp (C > T) (rs25487) and Arg399Gln (G > A) (rs1799782) polymorphisms in GBC susceptibility...
  56. ncbi Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma
    I C Van den Bos
    Department of Radiology, University Medical Center Rotterdam, The Netherlands
    Br J Radiol 80:e317-20. 2007
    ..In presenting this patient, we would like to emphasise the role of MRI as a problem-solving tool for analysis of rare tumours of non-hepatocellular origin, including hepatoid adenocarcinoma of the gallbladder...
  57. ncbi Gallbladder carcinoma: radiologic-pathologic correlation
    A D Levy
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Rm M 121, Washington, DC 20306 6000, USA
    Radiographics 21:295-314; questionnaire, 549-55. 2001
    ..The radiologic differential diagnosis includes the more frequently encountered inflammatory conditions of the gallbladder, xanthogranulomatous cholecystitis, adenomyomatosis, other hepatobiliary malignancies, and metastatic disease...
  58. ncbi Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation
    Wei Wang
    Renji Hospital, Shanghai Jiao Tong University School of Medicine, China
    Biochem Pharmacol 79:1134-40. 2010
    ..In conclusion, emodin can work as an adjunct to enhance the anticancer effect of platinum drugs in gallbladder cancer cells via ROS-related mechanisms...
  59. ncbi Analysis of the extent of resection for adenocarcinoma of the gallbladder
    Michael D'Angelica
    Hepatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 16:806-16. 2009
    ..Major hepatic resections, including major hepatectomy and CBD excision, are appropriate when necessary to clear disease but are not mandatory in all cases...
  60. ncbi Lymph nodal involvement as prognostic factor in gallbladder cancer: location, count or ratio?
    Sanjay Singh Negi
    Department of Surgical Gastroenterology and Liver Transplantation, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060, India
    J Gastrointest Surg 15:1017-25. 2011
    ..Controversy exists regarding optimal categorization of nodal status, and no study has investigated the relevance of metastatic to examined nodes ratio (LNR) in these patients...
  61. ncbi Unilateral versus bilateral endoscopic hepatic duct drainage in patients with malignant hilar biliary obstruction: results of a prospective, randomized, and controlled study
    G D De Palma
    Department of Surgery and Advanced Technologies, Service of Digestive Endoscopy, University of Naples Federico II, School of Medicine, Naples, Italy
    Gastrointest Endosc 53:547-53. 2001
    ..0247). CONCLUSION: The insertion of more than one stent would not appear justified as a routine procedure in patients with biliary bifurcation tumors...
  62. ncbi Surgical management of gallbladder cancer
    Srinevas K Reddy
    Department of Surgery, Duke University Medical Center, Box 3247, Durham, NC 27710, USA
    Surg Oncol Clin N Am 18:307-24, ix. 2009
    ..Large retrospective and underpowered prospective studies have suggested benefit to adjuvant chemotherapy or radiotherapy; however, these results need to be confirmed with large prospective randomized trials...
  63. ncbi [Vasculogenic mimicry in human primary gallbladder carcinoma and clinical significance thereof]
    Yue Zu Fan
    Department of Surgery, Tongji Hospital of Tongji University, Shanghai 200065, China Email
    Zhonghua Yi Xue Za Zhi 87:145-9. 2007
    ..To investigate if there is vasculogenic mimicry (VM) in human primary gallbladder carcinoma and clinical significance thereof...
  64. ncbi Recent trends of gallbladder cancer in Japan: an analysis of 4,770 patients
    Masato Kayahara
    Department of Gastroenterological Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Cancer 110:572-80. 2007
    ....
  65. pmc Gallbladder cancer: the role of laparoscopy and radical resection
    Samuel P Shih
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 245:893-901. 2007
    ..We assess how laparoscopy has altered the presentation of patients with gallbladder cancer and determine whether radical resection in patients with gallbladder cancer is beneficial...
  66. ncbi [Gallbladder polyps: how should they be treated and when?]
    Ana Sofia Bento de Matos
    Hospitais, Universidade Coimbra, Coimbra, Portugal
    Rev Assoc Med Bras 56:318-21. 2010
    ....
  67. ncbi A case of ovarian metastasis of gall bladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature
    V Jain
    Department of Surgery, Kasturba Medical College, Manipal, Karnataka, India
    Int J Gynecol Cancer 16:319-21. 2006
    ..While clinical and imaging results suggested a primary ovarian carcinoma with incidental cholelithiasis and choledocholithiasis, the final diagnosis was obtained on the basis of histopathologic findings of resected specimen...
  68. ncbi Expression and clinical significance of cell cycle regulatory proteins in gallbladder and extrahepatic bile duct cancer
    Wan Bae Kim
    Department of Surgery, Korea University Medical College Guro Hospital, 80 Guro dong, Guro Gu, Seoul, 152 703, South Korea
    Ann Surg Oncol 16:23-34. 2009
    ....
  69. ncbi Immunoreactivity for hepatocyte paraffin 1 antibody in hepatoid adenocarcinomas of the gastrointestinal tract
    A Maitra
    Division of Anatomic Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Am J Clin Pathol 115:689-94. 2001
    ..Adenocarcinomas with hepatoid features must be considered in the differential diagnosis of Hep Par 1-positive lesions...
  70. ncbi Hormones and gallbladder cancer in women
    Savio G Barreto
    Department of General and Digestive Surgery, Flinders Medical Center, Adelaide, Australia
    Indian J Gastroenterol 28:126-30. 2009
    ..The data on the association of hormone receptor expression to tumor differentiation is contradictory and needs further evaluation...
  71. ncbi Haplotype analysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancer
    Sachchida Nand Pandey
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Liver Int 27:1008-15. 2007
    ..We examined the effect of these polymorphisms individually as well as their haplotypes on GBC and gallstone patients in North Indian population...
  72. ncbi Gall bladder carcinoma in patients undergoing cholecystectomy for cholelithiasis
    Abdul Samad
    Department of Surgery, Isra University Hospital, Hyderabad, Sindh
    J Pak Med Assoc 55:497-9. 2005
    ..To determine the proportion and timing for suspecting the diagnosis of gall bladder carcinoma in patients undergoing cholecystectomy for cholelithiasis...
  73. pmc Is there any justification for the routine histological examination of straightforward cholecystectomy specimens?
    B Darmas
    Department of General Surgery, Wrexham Maelor Hospital, Wrexham, UK
    Ann R Coll Surg Engl 89:238-41. 2007
    ..The aim of the study was to assess the incidence of gall bladder carcinoma and the possibility of reducing the routine histological examination of gall bladder specimens...
  74. ncbi Gallbladder metastasis from malignant melanoma: diagnosis with FDG PET/CT
    Bhavya Rehani
    Kettering Medical Center, Wright State University, Dayton, Ohio 45429, USA
    Clin Nucl Med 31:812-3. 2006
    ..PET/CT detects metastasis at unusual sites accurately and is helpful in correct staging and management of patients with melanoma...
  75. ncbi Prognostic significance of the number of positive lymph nodes in gallbladder cancer
    Itaru Endo
    Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, Yokohama, Japan
    J Gastrointest Surg 10:999-1007. 2006
    ....
  76. pmc Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582
    Amita Chaube
    Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
    BMC Cancer 6:126. 2006
    ..The p53 and c-erbB-2 are the best examples of it. In the present study, our aim was to determine the role of these genes in the carcinogenesis of gallbladder by immunohistochemistry...
  77. ncbi Gallbladder cancer: an analysis of a series of 139 patients with invasion restricted to the subserosal layer
    Xabier de Aretxabala
    Department of Surgery, German Clinic, Vitacura 5951, Santiago, Chile
    J Gastrointest Surg 10:186-92. 2006
    ..The presence of lymph node metastases represents the main poor prognosis factor, and some type of adjuvant therapy should be studied in this particular group...
  78. ncbi [Why is gallbladder cancer more frequent in women than in men?]
    Naoto Egawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital
    Nihon Rinsho 64:344-7. 2006
  79. ncbi E-cadherin and beta-catenin expression in normal, inflamed and cancerous gallbladder tissue
    Harald Puhalla
    Department of General Surgery, General Hospital, Medical University of Vienna, 1090 Vienna, Austria
    Anticancer Res 25:4249-54. 2005
    ..The aim of this study was to investigate the expression of E-cadherin and beta-catenin in normal gallbladder mucosa, inflamed gallbladder tissue and GBC...
  80. pmc Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women
    Sergio Baez
    Division of Social and Environmental Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    World J Gastroenterol 16:372-8. 2010
    ..To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC)...
  81. ncbi Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases
    A Maitra
    Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Surg Pathol 25:595-601. 2001
    ..In contrast to pulmonary small cell carcinomas, p16INK4a function appears to be abrogated more frequently in these carcinomas...
  82. ncbi Expressive levels of MUC1 and MUC5AC and their clinicopathologic significances in the benign and malignant lesions of gallbladder
    Li Xiong
    Department of General Surgery, Second Xiangya Hospital of Central South University, Changsha, China
    J Surg Oncol 105:97-103. 2012
    ..This article is intended to make a study on the expressive levels of mucin core proteins (MUC1 and MUC5AC) and detect their clinicopathologic significances in the benign and malignant lesions of gallbladder...
  83. ncbi Gallbladder metastasis: spectrum of imaging findings
    Maria Luisa Barretta
    Department of Radiology, National Cancer Institute, G Pascale Foundation, Via Mariano Semmola, Naples, Italy
    Abdom Imaging 36:729-34. 2011
    ..Gallbladder metastasis is a rare but possible occurrence. Knowledge of the typical imaging features and careful evaluation of the gallbladder may avoid an incorrect or false negative diagnosis...
  84. pmc Mucin-producing carcinoma of the gallbladder: evaluation by magnetic resonance cholangiopancreatography in three cases
    Seiji Ishiguro
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Korean J Radiol 13:637-42. 2012
    ..Thus, gadolinium-enhanced MR imaging is mandatory for the precise diagnosis of the mucin-producing carcinoma of the gallbladder...
  85. ncbi Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas
    Juan C Roa
    Department of Pathology, Universidad de La Frontera, Temuco, Chile
    Mod Pathol 24:1069-78. 2011
    ..Most patients died within a few months; however, those few who were alive beyond 2 years in this cohort experienced long-term survival...
  86. ncbi Is routine histological examination of gall bladder specimens justifiable?
    M I M De Zoysa
    Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka
    Ceylon Med J 55:13-6. 2010
    ..To assess the safety of confining histological examination to gall bladders with radiological and macroscopic features suggestive of cancer...
  87. pmc A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature
    Merieme Ghaouti
    Department of Pathology, Ibn Sina Univesity Hospital, Rabat, Morocco
    Diagn Pathol 8:4. 2013
    ..Cholecystectomy should be performed to obtain a definitive diagnosis and to improve survival in case of solitary metastatic renal cell carcinoma...
  88. ncbi Carcinoma of the gallbladder: a retrospective review of 99 cases
    M Pandey
    Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Dig Dis Sci 46:1145-51. 2001
    ..Carcinoma of the gallbladder is difficult to diagnose early due to its vague symptomatology. A high index of suspicion and health education seem to be the only answers available for early detection and improvement of survival...
  89. ncbi Laparoscopic cholecystectomy for gallbladder lymphangiomas
    H R Yang
    Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5 Fu Shin Street, Kweishan, Taoyuan 333, Taiwan
    Surg Endosc 17:1676. 2003
    ..This report describes two patients with cystic lymphangiomas originating in the gallbladder. The correct diagnosis was made preoperatively in one patient, and both patients were treated successfully by laparoscopy...
  90. ncbi Expression pattern of tumor endothelial marker 8 protein in gallbladder carcinomas
    Sanjeev Kumar Maurya
    Surgical Oncology, Institute of Medical Science, Banaras Hindu University, Varanasi, India
    Asian Pac J Cancer Prev 12:507-12. 2011
    ..Conclusions- These results suggest that TEM8 plays an unknown important biological role to promote tumor angiogenesis in GBC...
  91. ncbi Rising incidence of biliary tract cancers in Shanghai, China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7368, USA
    Int J Cancer 75:368-70. 1998
    ..The increase in incidence was seen for all 3 subsites, both sexes, and all age groups. Future studies are needed to identify reasons for the large increases in these rates...
  92. ncbi Two types of extended liver resection for advanced gallbladder cancer: how to do it
    Satoshi Kondo
    Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Dig Surg 28:148-53. 2011
    ..Extended liver resection is necessary for advanced gallbladder cancer with hepatic involvement to achieve R0 resection. However, its type or extent and its surgical technique have yet to be established...
  93. ncbi Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC)
    A Duffy
    Department of Medicine, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY 10021, USA
    J Surg Oncol 98:485-9. 2008
    ..The incidence of gallbladder cancer (GBC) in the US is 1.2/100,000. This report examines the patterns of presentation, adjuvant treatment and survival of a large cohort of patients with GBC evaluated at MSKCC over a 10-year period...
  94. ncbi Gallbladder adenocarcinoma arising in Rokitansky-Aschoff sinus
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan
    Pathol Int 58:806-9. 2008
    ..In summary, minute subserosal adenocarcinoma, which arose in RAS, was found incidentally; therefore careful examination of resected gallbladders is necessary...
  95. ncbi Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: a possible stem cell tumor?
    Alberto E Paniz Mondolfi
    Department of Pathology and Laboratory Medicine, St Luke s Roosevelt Hospital Center, St Luke s Division, Clark 4, 1111 Tenth Avenue, New York, NY 10025, USA
    Pathol Int 61:608-14. 2011
    ..The aforementioned histological, ultrastructural and immunohistochemical profile is strongly suggestive of a biphenotypic stem/progenitor cell tumor of the gallbladder...
  96. ncbi Gall bladder cancer, extrahepatic bile duct cancer and ampullary carcinoma in New Zealand: Demographics, pathology and survival
    Jonathan Koea
    Hepatobiliary and Upper Gastrointestinal Unit, Department of Surgery, Auckland Hospital, New Zealand
    ANZ J Surg 72:857-61. 2002
    ..The aim of present paper was to document the incidence of gall bladder cancer, cancer of the extrahepatic bile ducts and ampullary carcinoma in New Zealand...
  97. ncbi Intraluminal polypoid metastasis of renal cell carcinoma in gallbladder mimicking gallbladder polyp
    Xueping Fang
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Arch Pathol Lab Med 134:1003-9. 2010
    ..Metastatic renal cell carcinoma (RCC) in gallbladder is rare with only 18 cases published in the English literature...
  98. ncbi Invasion of the hepatic artery is a crucial predictor of poor outcomes in gallbladder carcinoma
    Akihiko Kobayashi
    Departments of Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    World J Surg 36:645-50. 2012
    ..In the present study we undertook a retrospective analysis of gallbladder carcinoma to assess whether histologically determined hepatic artery (HA) invasion and portal vein (PV) invasion can be considered prognostic factors...
  99. ncbi Gallbladder cancer involving the extrahepatic bile duct is worthy of resection
    Hideki Nishio
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 253:953-60. 2011
    ..To clarify the value of resection of gallbladder cancer involving the extrahepatic bile duct...
  100. ncbi Surgery for gallbladder cancer: a population-based analysis
    Natalie G Coburn
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Surg 207:371-82. 2008
    ..Single institutional studies report an aggressive surgical approach improves survival. This analysis was performed to examine the components of surgical resection and resultant survival...
  101. ncbi Gallbladder small cell carcinoma Xenograft established by serial transplantation in nude mice
    Chiyoko Nishime
    Central Institute for Experimental Animals, 1430 Nogawa, Miyamae ku, Kawasaki, Japan
    Anticancer Res 26:79-83. 2006
    ..The xenograft line retained histological and immunohistochemical characteristics of the primary gallbladder tumor and is the first reported xenotransplantable tumor of human gallbladder small cell carcinoma...

Research Grants12

  1. CLINICAL AND BIOLOGICAL BASIS OF 18F-FDG PET IN CANCER
    Yuman Fong; Fiscal Year: 2001
    ..abstract_text> ..
  2. Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic Malignancy
    William Jarnagin; Fiscal Year: 2008
    ..Furthermore, several important clinical issues are addressed by the proposed correlative studies, the results of which would be of broad general interest in clinical oncology. [unreadable] [unreadable] [unreadable]..
  3. Liver Regeneration in Man--Effects or Adjuvant Therapy
    Yuman Fong; Fiscal Year: 2005
    ....
  4. CASE CONTROL STUDY OF STATIN USE AND LARGE BOWEL CANCER
    Patricia Coogan; Fiscal Year: 2004
    ..S. men and women are high, an inverse association would be of considerable public health importance. Moreover, it would shed light on a mechanism of colon carcinogenesis. ..
  5. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  6. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  7. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  8. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  9. Effect of Urban Form on Exercise and BMI in Black Women
    Patricia Coogan; Fiscal Year: 2009
    ..The proposed study has the potential to provide such evidence and to impact policy in the domains of both transportation/urban planning and public health. ..
  10. DIET AND DURATION OF CERVICAL HPV INFECTION
    MARC GOODMAN; Fiscal Year: 2009
    ....
  11. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..