barrett esophagus

Summary

Summary: A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.

Top Publications

  1. pmc Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis
    Brian J Reid
    Divisions of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 98109 Seattle, USA
    Nat Rev Cancer 10:87-101. 2010
  2. pmc MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival
    Ewy A Mathe
    Laboratory of Human Carcinogenesis, National Cancer Institute NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 15:6192-200. 2009
  3. ncbi Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 340:825-31. 1999
  4. ncbi Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:3414-27. 2004
  5. pmc MicroRNA expression profiles of esophageal cancer
    Andrew Feber
    Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA
    J Thorac Cardiovasc Surg 135:255-60; discussion 260. 2008
  6. pmc Predictors of progression in Barrett's esophagus III: baseline flow cytometric variables
    P S Rabinovitch
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Gastroenterol 96:3071-83. 2001
  7. doi Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus
    Kenneth K Wang
    Gastroenterology, College of Medicine, Tucson, AZ 85724, USA
    Am J Gastroenterol 103:788-97. 2008
  8. pmc Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus
    Massimiliano Di Pietro
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Research Centre, CB2 0XZ Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 109:9077-82. 2012
  9. pmc New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical management
    Brian J Reid
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, P O Box 19024, Seattle, WA 98109, USA
    Clin Cancer Res 17:3512-9. 2011
  10. ncbi Acid, bile, and CDX: the ABCs of making Barrett's metaplasia
    Rhonda F Souza
    Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, USA
    Am J Physiol Gastrointest Liver Physiol 295:G211-8. 2008

Detail Information

Publications380 found, 100 shown here

  1. pmc Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis
    Brian J Reid
    Divisions of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 98109 Seattle, USA
    Nat Rev Cancer 10:87-101. 2010
    ..Given that 95% of oesophageal adenocarcinomas arise in individuals without a prior diagnosis of Barrett's oesophagus, what strategies can be used to reduce late diagnosis of oesophageal adenocarcinoma?..
  2. pmc MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival
    Ewy A Mathe
    Laboratory of Human Carcinogenesis, National Cancer Institute NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 15:6192-200. 2009
    ....
  3. ncbi Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    J Lagergren
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 340:825-31. 1999
    ..The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors...
  4. ncbi Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:3414-27. 2004
    ..Virtually all of the other lesion expansions, including microsatellite shifts, could be explained as hitchhikers on p16 lesion clonal expansions. These techniques can be applied to any neoplasm...
  5. pmc MicroRNA expression profiles of esophageal cancer
    Andrew Feber
    Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA
    J Thorac Cardiovasc Surg 135:255-60; discussion 260. 2008
    ..The purpose of our study was to examine microRNA expression in Barrett esophagus and esophageal cancer to identify potential markers for disease progression.
  6. pmc Predictors of progression in Barrett's esophagus III: baseline flow cytometric variables
    P S Rabinovitch
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Gastroenterol 96:3071-83. 2001
    ..Careful examination of cytometric variables revealed a better definition of those parameters that are most closely associated with increased cancer risk...
  7. doi Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus
    Kenneth K Wang
    Gastroenterology, College of Medicine, Tucson, AZ 85724, USA
    Am J Gastroenterol 103:788-97. 2008
  8. pmc Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus
    Massimiliano Di Pietro
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Research Centre, CB2 0XZ Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 109:9077-82. 2012
    b>Barrett esophagus (BE) is a human metaplastic condition that is the only known precursor to esophageal adenocarcinoma...
  9. pmc New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical management
    Brian J Reid
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, P O Box 19024, Seattle, WA 98109, USA
    Clin Cancer Res 17:3512-9. 2011
    ..The challenge for investigators of Barrett's esophagus lies in integrating knowledge about genomic instability and clonal evolution into clinical management to increase the lifespan and quality of life of individuals with this condition...
  10. ncbi Acid, bile, and CDX: the ABCs of making Barrett's metaplasia
    Rhonda F Souza
    Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, USA
    Am J Physiol Gastrointest Liver Physiol 295:G211-8. 2008
    ..The role of stem cells in the development of metaplasia and in carcinogenesis and the potential for therapies directed at those stem cells also is addressed...
  11. ncbi Abdominal obesity and the risk of Barrett's esophagus
    Hashem B El-Serag
    The Section of Gastroenterology, Houston Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Am J Gastroenterol 100:2151-6. 2005
    ..The association between overweight/obesity and the risk of Barrett's esophagus (BE) is unclear. Further, the association between body fat distribution and the risk of BE is unknown...
  12. pmc NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy
    Mohamed M M Abdel-Latif
    Department of Clinical Surgery, Trinity Centre for Health Sciences, St James s Hospital and Trinity College Dublin, Dublin 8, Ireland
    Ann Surg 239:491-500. 2004
    ....
  13. pmc NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma
    Patricia C Galipeau
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e67. 2007
    ..We aimed to evaluate somatic genetic abnormalities with NSAIDs as predictors of EA in a prospective cohort study of patients with BE...
  14. ncbi Risk of esophageal adenocarcinoma and mortality in patients with Barrett's esophagus: a systematic review and meta-analysis
    Marjolein Sikkema
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Clin Gastroenterol Hepatol 8:235-44; quiz e32. 2010
    ..We therefore performed a systematic review and meta-analysis to determine the incidence of EAC and mortality due to EAC in BE under surveillance...
  15. ncbi Cdx2 as a marker of epithelial intestinal differentiation in the esophagus
    Roy W Phillips
    Department of Pathology, University of Virginia Medical Center, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 27:1442-7. 2003
    ..Acid mucin in non-goblet columnar cells is a common feature of Barrett's and junctional-type epithelium and may not always be indicative of intestinal metaplasia...
  16. ncbi Loss of heterozygosities in Barrett esophagus, dysplasia, and adenocarcinoma detected by esophageal brushing cytology and gastroesophageal biopsy
    Xiaoqi Lin
    Department of Pathology, Northwestern University, 251 East Huron Street, Chicago, IL 60611, USA
    Cancer 117:57-66. 2009
    ..Esophageal brushing cytology (EBC) and gastroesophageal biopsy (GEB) are complementary procedures for the evaluation of gastroesophageal lesions that help guide surveillance and treatment...
  17. ncbi Barrett's esophagus in Japanese patients: its prevalence, form, and elongation
    Koichi Okita
    Department of Gastroenterology, Shimane University, School of Medicine, Izumo, Japan
    J Gastroenterol 43:928-34. 2008
    ..To address this issue, we investigated the change in the prevalence and length of short-segment Barrett's esophagus (SSBE) over time...
  18. pmc Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome
    J Pal
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02132, USA
    Oncogene 30:3585-98. 2011
    ....
  19. ncbi Risk stratification of Barrett's esophagus: updated prospective multivariate analysis
    Allan P Weston
    Veterans Administration Medical Center 111C, 4801 E Linwood Boulevard, Kansas City, MO 64128 2226, USA
    Am J Gastroenterol 99:1657-66. 2004
    ..Prospective evaluation of Barrett's esophagus (BE) in order to determine what demographic, endoscopic, and histologic features are predictive of the prevalence and incidence of Barrett's high-grade dysplasia (HGD) and adenocarcinoma (Ca)...
  20. pmc A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus
    Zhe Jin
    Gastroenterology Division, Johns Hopkins University, Baltimore, MD 21287, USA
    Cancer Res 69:4112-5. 2009
    ..118, respectively) in all 3 models. A methylation biomarker-based panel to predict neoplastic progression in BE has potential clinical value in improving both the efficiency of surveillance endoscopy and the early detection of neoplasia...
  21. pmc Expression of the Na+/I- symporter (NIS) is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus
    Aron Altorjay
    Department of Surgery, St George University Teaching Hospital H 8000 Székesfehérvár, Hungary
    BMC Cancer 7:5. 2007
    ..Whereas NIS expression and regulation have been extensively investigated in healthy and neoplastic thyroid and breast tissues, little is known about NIS expression and function along the healthy and diseased gastrointestinal tract...
  22. ncbi Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett's esophagus and esophageal adenocarcinoma
    Vivianda Menke
    Departments of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Hum Genet 57:26-32. 2012
    ..This indicates that reduced mucosal protection resulting from genetically decreased EGF expression enhances esophageal tumor development...
  23. ncbi Predictors for neoplastic progression in patients with Barrett's Esophagus: a prospective cohort study
    M Sikkema
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Gastroenterol 106:1231-8. 2011
    ..The aim of this study was to identify such predictors of progression to high-grade dysplasia (HGD) and EAC in patients with BE after 4 years of surveillance and to develop a prediction model based on these factors...
  24. pmc A labelled discrete choice experiment adds realism to the choices presented: preferences for surveillance tests for Barrett esophagus
    Michelle E Kruijshaar
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    BMC Med Res Methodol 9:31. 2009
    ..We conducted a labelled discrete choice experiment with realistic choices to investigate patients' trade-offs between the expected health gains and the burden of testing in surveillance of Barrett esophagus (BE).
  25. ncbi Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagus
    Dominique P Coco
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 35:45-54. 2011
    Recent morphologic and molecular evidence suggests that dysplasia in Barrett esophagus (BE) begins in the bases of the crypts [crypt dysplasia (CD)] and progresses with time to involve the upper portions of the crypts and surface ..
  26. pmc The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett's esophageal carcinogenesis
    Rom S Leidner
    Division of Hematology and Oncology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Genes Chromosomes Cancer 51:473-9. 2012
    ..Taken together, we propose miR-31 and -375 as novel candidate microRNAs specifically associated with early- and late-stage malignant progression, respectively, in Barrett's esophagus...
  27. pmc Association of insulin and insulin-like growth factors with Barrett's oesophagus
    Katarina B Greer
    Division of Gastroenterology and Liver Disease, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Gut 61:665-72. 2012
    ..The relationship of insulin, IGF-1 and IGF binding proteins (IGFBP) with Barrett's oesophagus (BO) has not been well examined...
  28. ncbi An economic analysis of endoscopic ablative therapy for management of nondysplastic Barrett's esophagus
    A Das
    Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Endoscopy 41:400-8. 2009
    ..The aim of the current study was to perform an economic analysis evaluating the cost-effectiveness of endoscopic ablation of nondysplastic Barrett's esophagus...
  29. pmc Risk of malignant progression in Barrett's esophagus patients: results from a large population-based study
    Shivaram Bhat
    Centre for Public Health, Queens University Belfast, Institute of Clinical Sciences Building, Belfast BT12 6BA, Northern Ireland, UK
    J Natl Cancer Inst 103:1049-57. 2011
    ....
  30. ncbi Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus
    Pilar Jimenez
    Aragonés Institute of Health Sciences, and Gastroenterology Service, Lozano Blesa University Hospital Clinic, Avenida San Juan Bosco, C Domingo Miral, s n 15 50009 Zaragoza, Spain
    World J Gastroenterol 11:2697-703. 2005
    ..Experimental studies suggest that free radicals are involved in acid and pepsin-induced damage of esophageal mucosa. The profile and balance between free radicals and antioxidant systems in human esophagitis are unknown...
  31. ncbi Low-grade dysplasia in Barrett's esophagus: overdiagnosed and underestimated
    Wouter L Curvers
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Am J Gastroenterol 105:1523-30. 2010
    ..We investigated the natural history of LGD in a large community-based cohort of BE patients after reviewing the original histological diagnosis by an expert panel of pathologists...
  32. ncbi Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes in Barrett's adenocarcinoma
    Bettina Albrecht
    University Hospital Freiburg, Institute of Pathology, Freiburg i Br, Germany
    J Pathol 203:780-8. 2004
    ..The newly identified genes may include so far unknown biomarkers in BCA and are therefore a starting point for further studies elucidating their possible role in Barrett's carcinogenesis...
  33. pmc Induction of intestinalization in human esophageal keratinocytes is a multistep process
    Jianping Kong
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Carcinogenesis 30:122-30. 2009
    ..We conclude that ectopic proliferation signals, alterations in epigenetic gene regulation and the inhibition of tumor suppressor mechanisms are required for Cdx2-mediated intestinalization of human esophageal keratinocytes in BE...
  34. ncbi The association between alcohol and reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma
    Lesley A Anderson
    Centre for Public Health, Queen s University, Belfast, Northern Ireland
    Gastroenterology 136:799-805. 2009
    ..However, reports about the association between alcohol and reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma are conflicting...
  35. ncbi Barrett's oesophagus
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, NC, USA
    Lancet 373:850-61. 2009
    ..We conclude with a discussion of future directions for research, focusing on treatment of early neoplasia, and modifications of current practices to show our evolving understanding of this condition...
  36. pmc Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium
    H Kazumori
    Department of Gastroenterology and Hepatology, Shimane University, School of Medicine, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    Gut 55:16-25. 2006
    ..In addition, morphological and histochemical changes in squamous cells to intestinal epithelial cells were studied in response to bile acid induced expression of Cdx2...
  37. ncbi Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis
    S Wang
    Division of Gastroenterology, Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Oncogene 25:3346-56. 2006
    ..These findings suggest that changes modulated at the molecular biologic level supervene earlier than histologic changes, and that BE is an early intermediate stage in the process of EAC...
  38. ncbi MicroRNA profiling of Barrett's oesophagus and oesophageal adenocarcinoma
    B P L Wijnhoven
    Department of Surgery, Flinders University, Bedford Park, South Australia, Australia
    Br J Surg 97:853-61. 2010
    ..The aberrant expression of microRNAs (miRNAs) is involved in the development of cancer. This study examined whether miRNAs play a role in the development of oesophageal adenocarcinoma...
  39. ncbi NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes
    Irene Georgakoudi
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cancer Res 62:682-7. 2002
    ....
  40. ncbi Narrow band imaging for characterization of high grade dysplasia and specialized intestinal metaplasia in Barrett's esophagus: a meta-analysis
    J Mannath
    Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Queens Medical Centre Campus, University of Nottingham, UK
    Endoscopy 42:351-9. 2010
    ..We aimed to assess the diagnostic accuracy of NBI with magnification for the diagnosis of high grade dysplasia (HGD) and specialized intestinal metaplasia (SIM) in patients with Barrett's esophagus...
  41. ncbi Screening for Barrett's esophagus in colonoscopy patients with and without heartburn
    Douglas K Rex
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Gastroenterology 125:1670-7. 2003
    ..The population prevalence of Barrett's esophagus (BE) is uncertain. Our aim was to describe the prevalence of BE in a volunteer population...
  42. pmc Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers
    Amel Saadi
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Research Centre, Cambridge CB22 0XZ, United Kingdom
    Proc Natl Acad Sci U S A 107:2177-82. 2010
    ..These data implicate inflammatory pathways in the genesis of gastrointestinal tract cancers, which can affect prognosis...
  43. ncbi Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study
    Thomas L Vaughan
    Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, Seattle, WA 98109, USA
    Lancet Oncol 6:945-52. 2005
    ..We aimed to assess the role of NSAID in the development of oesophageal adenocarcinoma and precursor lesions in people with Barrett's oesophagus--a metaplastic disorder that confers a high risk of oesophageal adenocarcinoma...
  44. ncbi Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead?
    Robert H Riddell
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Gastroenterol 104:2588-94. 2009
    ..Guidelines for the diagnosis of BE need to consider revisions that take into account new data regarding nongoblet cell epithelium in BE, and the difficulties in recognizing columnar metaplasia that measures less than 1 cm in length...
  45. ncbi The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Res 64:7629-33. 2004
    ..This implies that interventions that limit expansion of genetically unstable clones may reduce risk of progression to cancer...
  46. ncbi Reproducibility of the diagnosis of dysplasia in Barrett esophagus: a reaffirmation
    E Montgomery
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Hum Pathol 32:368-78. 2001
    Morphologic assessment of dysplasia in Barrett esophagus, despite limitations, remains the basis of treatment. We rigorously tested modified 1988 criteria, assessing intraobserver and interobserver reproducibility...
  47. pmc Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus
    Katerina Dvorak
    Department of Cell Biology and Anatomy, PO Box 245044, University of Arizona, Tucson, AZ 85724, USA
    Gut 56:763-71. 2007
    ..Barrett's oesophagus is a premalignant condition associated with an increased risk for the development of oesophageal adenocarcinoma (ADCA). Previous studies indicated that oxidative damage contributes to the development of ADCA...
  48. pmc New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett's oesophagus
    R J Playford
    Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Gut 55:442. 2006
  49. ncbi Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett's esophagus: international, partially blinded, randomized phase III trial
    Bergein F Overholt
    Thompson Cancer Survival Center, Knoxville, Tennessee, USA
    Gastrointest Endosc 62:488-98. 2005
    ..The objective was to examine the impact of treating patients with BE and with HGD by using porfimer sodium (POR) and photodynamic therapy (PDT) for ablating HGD and reducing the incidence of esophageal adenocarcinoma...
  50. ncbi Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa
    Akashi Eda
    Department of Internal Medicine, Jichi Medical School, Yakushiji, Kawachi, Tochigi 329 0438, Japan
    J Gastroenterol 38:14-22. 2003
    ..The present study was designed to examine the expression of CDX 1/2 in inflammatory esophageal mucosa with or without Barrett's epithelium...
  51. ncbi Metabolic profiling detects field effects in nondysplastic tissue from esophageal cancer patients
    Danny Yakoub
    Department of Surgery and Cancer, Imperial College London, St Mary s Hospital, London, United Kingdom
    Cancer Res 70:9129-36. 2010
    ..This indicates that metabolic profiling of tissue can potentially play a role in the surveillance of cancer by reporting on the phenotypic consequences of field cancerization...
  52. ncbi Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus
    Reginald V N Lord
    Department of Surgery and Cardiothoracic Surgery, University of Southern California Keck School of Medicine, Los Angeles, USA
    J Thorac Cardiovasc Surg 125:246-53. 2003
    ..the role of the angiogenic factors vascular endothelial growth factor and basic fibroblast growth factor in the development and progression of Barrett esophagus and adenocarcinomas of the esophagus and gastroesophageal junction.
  53. pmc Visceral obesity and the risk of Barrett's esophagus in Japanese patients with non-alcoholic fatty liver disease
    Tomoyuki Akiyama
    Gastroenterology Division, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
    BMC Gastroenterol 9:56. 2009
    ..The association between obesity and the risk of Barrett's esophagus (BE) is unclear. Furthermore, the association between visceral obesity and the risk of BE is entirely unknown...
  54. pmc MicroRNA expression signatures in Barrett's esophagus and esophageal adenocarcinoma
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:5744-52. 2009
    ..Although microRNA (miRNA) expression signatures have been associated with the etiology and prognosis of several types of cancers, their roles in the development of esophageal adenocarcinoma have not been extensively evaluated...
  55. pmc Current status of Barrett's esophagus research in Asia
    Chi Yang Chang
    Department of Internal Medicine, E Da Hospital and I Shou University, Kaohsiung County, Taiwan
    J Gastroenterol Hepatol 26:240-6. 2011
    ..At present, data regarding the management and long-term outcome of BE are extremely limited in Asia. More studies of BE in this geographic area are warranted...
  56. ncbi Barrett's esophagus
    Wayne A Phillips
    Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    J Gastroenterol Hepatol 26:639-48. 2011
    ..Although known to arise as a consequence of chronic gastroesophageal reflux, the cellular and molecular mechanisms underlying development Barrett's esophagus and its progression to cancer remain unclear...
  57. ncbi The Veneto Region's Barrett's Oesophagus Registry: aims, methods, preliminary results
    G Zaninotto
    Department of General Surgery and Organ Transplantation, University of Padova, Padova, Italy
    Dig Liver Dis 39:18-25. 2007
    ..A Barrett's Oeosphagus Registry has been therefore established in the Veneto Region and neighbouring provinces...
  58. ncbi Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells
    Francesca Milano
    Laboratory of Experimental Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 132:2412-21. 2007
    ..In this study, the role of the BMP pathway in the metaplastic transformation of normal squamous cells into columnar cells was examined...
  59. ncbi Tethered capsule endoscopy, a low-cost and high-performance alternative technology for the screening of esophageal cancer and Barrett's esophagus
    Eric J Seibel
    Department of Mechanical Engineering, University of Washington, Human Photonics Lab, Box 352600, Seattle, WA 98195, USA
    IEEE Trans Biomed Eng 55:1032-42. 2008
    ....
  60. pmc Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma
    Arpad Juhasz
    Department of Surgery, Creighton University Medical Center, Omaha, NE, USA
    J Clin Gastroenterol 45:867-71. 2011
    The aim of this study is to determine the prevalence of Barrett esophagus (BE) in first-degree relatives of patients with esophageal adenocarcinoma (EAC) and Barrett high-grade dysplasia (HGD).
  61. ncbi Clinical and demographic predictors of Barrett's esophagus among patients with gastroesophageal reflux disease: a multivariable analysis in veterans
    M A Eloubeidi
    Institute for Clinical and Epidemiological Research, Veterans Affairs Medical Center, Durham, North Carolina, USA
    J Clin Gastroenterol 33:306-9. 2001
    ..The subgroup of patients with gastroesophageal reflux disease (GERD) that should undergo endoscopy to rule out Barrett's esophagus (BE) has not been well defined...
  62. ncbi Distribution and significance of epithelial types in columnar-lined esophagus
    P T Chandrasoma
    Departments of Surgical Pathology and Foregut Surgery, Keck School of Medicine at the University of Southern California, Los Angeles, USA
    Am J Surg Pathol 25:1188-93. 2001
    ..Recognition of these changes permits the development of morphologic definitions of reflux disease and the characterization of the sequence of epithelial changes that represent the reflux-adenocarcinoma sequence...
  63. pmc The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus
    K Koss
    Department of Gastroenterology, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
    J Clin Pathol 57:1156-9. 2004
    ..In tumours cells, M2-PK usually exists in dimeric form (tumour M2-PK), causing the accumulation of glycolytic phosphometabolites, which allows cells to invade areas with low oxygen and glucose concentrations...
  64. pmc Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study
    Lesley A Anderson
    Centre for Clinical and Population Sciences, Queen s University, Mulhouse Building, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland
    World J Gastroenterol 13:1585-94. 2007
    ..To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma...
  65. ncbi Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture
    Sabine Roman
    Digestive Physiology, Pavillon H, Hopital Edouard Herriot, Place d Arsonval, 69437 Lyon Cedex 03, France
    Am J Physiol Gastrointest Liver Physiol 293:G45-53. 2007
    ....
  66. ncbi Barrett's metaplasia
    J A Jankowski
    Division of Medical Sciences, University of Birmingham, UK
    Lancet 356:2079-85. 2000
    ..Locally produced cytokines and bile acids in the refluxate create a microenvironment that sets the scene for metaplastic transformation of the oesophageal epithelium, mainly by directly affecting metaplastic stem cells...
  67. pmc Waist-to-hip ratio, but not body mass index, is associated with an increased risk of Barrett's esophagus in white men
    Jennifer R Kramer
    Houston VA Health Services Research and Development Center of Excellence, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 11:373-381.e1. 2013
    ..We examined the effects of waist-to-hip ratio (WHR) and body mass index (BMI) on the risk of BE and investigated whether race, GERD symptoms, or hiatus hernia were involved...
  68. pmc Differential expression of Hsp27 in normal oesophagus, Barrett's metaplasia and oesophageal adenocarcinomas
    O S Soldes
    Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109, USA
    Br J Cancer 79:595-603. 1999
    ....
  69. pmc TP53 and progression from Barrett's metaplasia to oesophageal adenocarcinoma in a UK population cohort
    L Murray
    Centre for Clinical and Population Sciences, The Queen s University of Belfast, Mulhouse Building, The Royal Group of Hospitals, Belfast, UK
    Gut 55:1390-7. 2006
    ..Oesophageal adenocarcinoma frequently develops on a background of metaplastic Barrett's epithelium. The development of malignancy is accompanied by genetic alterations, which may be promising biomarkers of disease progression...
  70. ncbi Obesity and lifestyle risk factors for gastroesophageal reflux disease, Barrett esophagus and esophageal adenocarcinoma
    P J Veugelers
    Dalhousie University, Halifax, Nova Scotia, Canada
    Dis Esophagus 19:321-8. 2006
    ..was to examine the association of obesity with esophageal adenocarcinoma, and with the precursor lesions Barrett esophagus and gastroesophageal reflux disease (GERD)...
  71. pmc Molecular basis of Barrett's oesophagus and oesophageal adenocarcinoma
    R C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Gut 55:1810-20. 2006
  72. ncbi Barrett's esophagus is common in older men and women undergoing screening colonoscopy regardless of reflux symptoms
    Eric M Ward
    Department of Medicine, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Am J Gastroenterol 101:12-7. 2006
    ..This could be due to undiagnosed symptomatic GER and BE or BE/ACA occurring in patients without reflux symptoms. We have, therefore, studied the prevalence of BE and symptom status in older patients referred for colonoscopy...
  73. pmc Development and characterization of an organotypic model of Barrett's esophagus
    Rachelle E Kosoff
    Cancer Biology Program, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Cell Physiol 227:2654-9. 2012
    ....
  74. pmc Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma
    Ying Hao
    Department of Medicine, Stanford University, Stanford, California 94305 5187, USA
    Gastroenterology 131:925-33. 2006
    ....
  75. ncbi Non-biopsy detection of intestinal metaplasia and dysplasia in Barrett's esophagus: a prospective multicenter study
    P Sharma
    University of Kansas School of Medicine and Veterans Affairs Medical Center, Kansas City, MO, USA
    Endoscopy 38:1206-12. 2006
    ..Our aims were to assess the ability of MCE to predict the histological diagnosis (non-biopsy detection), to compare the yield of MCE-targeted versus random biopsies for dysplasia, and to compare procedure times...
  76. ncbi The perception of cancer risk in patients with prevalent Barrett's esophagus enrolled in an endoscopic surveillance program
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina Schools of Medicine and Public Health, Chapel Hill, 27599, USA
    Gastroenterology 129:429-36. 2005
    ..5% per year. Patients may have difficulty understanding this risk. This study assessed the perceived risk of cancer in patients with BE, and correlated their risk estimates with their health care use behaviors...
  77. pmc New models of neoplastic progression in Barrett's oesophagus
    Kirill Pavlov
    Division of Surgical Oncology, Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Biochem Soc Trans 38:331-6. 2010
    ..This is now possible and represents an exciting opportunity for the future...
  78. ncbi Effect of surveillance of Barrett's oesophagus on the clinical outcome of oesophageal cancer
    A Fountoulakis
    Academic Division of Surgery and Centre for Digestive Diseases, The General Infirmary, Leeds, UK
    Br J Surg 91:997-1003. 2004
    ..The aim of this study was to examine the impact of endoscopic surveillance on the clinical outcome of patients with adenocarcinoma complicating Barrett's oesophagus...
  79. ncbi CD1a and antitumour immune response
    Giampiero La Rocca
    Human Anatomy Section, Department of Experimental Medicine, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy
    Immunol Lett 95:1-4. 2004
    ..A recent report on the presence of CD1a in metaplastic epithelial cells of Barrett esophagus introduced new questions about CD1a expression patterns...
  80. pmc Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Clin Gastroenterol Hepatol 4:38-43. 2006
    ..The purpose of this study was to establish OCT image characteristics of IMC and HGD in Barrett's esophagus...
  81. pmc Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis
    Aaron Goldman
    Department of Cell Biology and Anatomy, Univ of Arizona, 1501 N Campbell Ave P O Box 245044, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 300:G292-302. 2011
    ..In summary, our study shows that long-term exposure of squamous cells to BA at acidic pH causes the cells to display the same characteristics and markers as BE...
  82. ncbi Cytokeratin and CDX-2 expression in Barrett's esophagus
    Jantine W P M van Baal
    Center for Experimental Molecular Medicine in Amsterdam, University Medical Center Utrecht, The Netherlands
    Scand J Gastroenterol 43:132-40. 2008
    ..The objective of this study was to determine the specificity of CDX-2 and a set of cytokeratins (CKs) as specific markers for BE as compared with normal squamous esophageal and gastric cardia tissue...
  83. ncbi Review article: towards consistency in the endoscopic diagnosis of Barrett's oesophagus and columnar metaplasia
    D Armstrong
    Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 20:40-7; discussion 61-2. 2004
    ..It is hoped that these propositions will be the first step in the development of standard endoscopic diagnostic criteria for Barrett's oesophagus, relevant to clinical practice and clinical research...
  84. ncbi Barrett's oesophagus--a pathologist's view
    J F Flejou
    Service d Anatomie Pathologique, Hopital Saint Antoine, AP HP, Paris, France
    Histopathology 50:3-14. 2007
    ..On the other hand, the role of pathologists now extends to the evaluation of new therapeutic modalities of early neoplastic lesions in Barrett's oesophagus, especially endoscopic mucosal resection...
  85. ncbi Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells
    Rhonda F Souza
    Department of Medicine, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 287:G743-8. 2004
    ..These findings suggest potential mechanisms whereby acid reflux might promote carcinogenesis in Barrett's esophagus...
  86. ncbi Characteristics of gastro-esophageal reflux episodes in Barrett's esophagus, erosive esophagitis and healthy volunteers
    E Savarino
    Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Neurogastroenterol Motil 22:1061-e280. 2010
    ..Still, there is controversy on the role of weakly acidic and weakly alkaline reflux in BE. To compare characteristics of reflux episodes patients with BE, erosive esophagitis (EE), and healthy volunteers (HV)...
  87. pmc Acceptability and accuracy of a non-endoscopic screening test for Barrett's oesophagus in primary care: cohort study
    Sudarshan R Kadri
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 2XZ
    BMJ 341:c4372. 2010
    ..To determine the accuracy and acceptability to patients of non-endoscopic screening for Barrett's oesophagus, using an ingestible oesophageal sampling device (Cytosponge) coupled with immunocytochemisty for trefoil factor 3...
  88. ncbi Frequency of the mitochondrial DNA 4977bp deletion in oesophageal mucosa during the progression of Barrett's oesophagus
    Benjamin H L Tan
    University of Edinburgh, Clinical and Surgical Sciences Surgery, Royal Infirmary, Edinburgh, UK
    Eur J Cancer 45:736-40. 2009
    ....
  89. ncbi Comparison of six immunohistochemical markers for the histologic diagnosis of neoplasia in Barrett's esophagus
    Andreas Weimann
    Institute for Laboratory Medicine and Pathobiochemistry, Charite University Medical Center, Berlin, Germany
    Virchows Arch 457:537-45. 2010
    ....
  90. pmc Predictors of progression in Barrett's esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression
    B J Reid
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Am J Gastroenterol 96:2839-48. 2001
    ..17p (p53) LOH is a predictor of progression in Barrett's esophagus that can be combined with a panel of other validated biomarkers for risk assessment as well as intermediate endpoints in prevention trials...
  91. ncbi Metabolomics study of esophageal adenocarcinoma
    Jian Zhang
    Department of Chemistry, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
    J Thorac Cardiovasc Surg 141:469-75, 475.e1-4. 2011
    ..The sensitivity and specificity of the study were evaluated not only for EAC but also for Barrett esophagus and high-grade dysplasia, which are widely regarded as precursors of EAC.
  92. ncbi Effect of a new diagnosis of Barrett's esophagus on insurance status
    Nicholas J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina Schools of Medicine and Public Health, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 100:577-80. 2005
    ..Despite this increased risk, most cohort studies demonstrate that the mean life expectancy of subjects with BE is no different than age-matched controls. The indirect costs associated with a diagnosis of BE are unclear...
  93. ncbi Mutations of BRAF and KRAS2 in the development of Barrett's adenocarcinoma
    Florian Sommerer
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, Leipzig 04103, Germany
    Oncogene 23:554-8. 2004
    ..We conclude that the disruption of the Raf/MEK/ERK (MAPK) kinase pathway is a frequent but also early event in the development of Barrett's adenocarcinoma...
  94. pmc Deletion at fragile sites is a common and early event in Barrett's esophagus
    Lisa A Lai
    Department of Pathology, University of Washington, Seattle, WA, USA
    Mol Cancer Res 8:1084-94. 2010
    ..Deletion and genomic instability at FRA3B and other fragile sites could thus be a biomarker of genetic damage in BE patients and a potential biomarker of cancer risk...
  95. ncbi Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteri
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology and Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Digestion 80:248-57. 2009
    ..Definitions and opinions in the field of gastroenterology vary widely in different countries...
  96. ncbi The natural history of dysplasia and cancer in esophagitis and Barrett esophagus
    Stuart Jon Spechler
    Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    J Clin Gastroenterol 36:S2-5; discussion S26-8. 2003
    The natural history of metaplasia and dysplasia in Barrett esophagus is not well defined...
  97. ncbi Prevention of adenocarcinoma by reversing Barrett's esophagus with mucosal ablation
    Richard E Sampliner
    Gastroenterology Section, VA Medical Center and Arizona Health Sciences Center, Tucson, Arizona 85723, USA
    World J Surg 27:1026-9. 2003
    ..This therapy offers the promise of less morbidity and greater quality of life than resection...
  98. ncbi The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma
    Erica di Martino
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute for Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom
    Genet Med 9:341-7. 2007
    The role of genetic susceptibility to esophageal adenocarcinoma and its precursor lesion Barrett esophagus has not been fully elucidated...
  99. ncbi Barrett's dysplasia and the Vienna classification: reproducibility, prediction of progression and impact of consensus reporting and p53 immunohistochemistry
    Philip V Kaye
    Department of Cellular Pathology, Nottingham University Hospitals, Queens Medical Centre Campus, Nottingham, UK
    Histopathology 54:699-712. 2009
    ....
  100. ncbi Hiatal hernia and acid reflux frequency predict presence and length of Barrett's esophagus
    Benjamin Avidan
    Department of Veterans Affairs Medical Center, Albuquerque, New Mexico 87108, USA
    Dig Dis Sci 47:256-64. 2002
    ..Mechanisms in addition to acid reflux must contribute to the development of Barrett's esophagus...
  101. ncbi Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction
    Amitabh Chak
    University Hospitals of Cleveland, Case School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Cancer Epidemiol Biomarkers Prev 15:1668-73. 2006
    ..The aim of this study was to determine the proportion of patients with these diseases who have familial Barrett's esophagus...

Research Grants62

  1. Flavonoids, esophageal/gastric cardia adenocarcinoma and Barretts Esophagus Risk
    Marilie D Gammon; Fiscal Year: 2013
    ..This would allow some EA and GCA to be prevented before individuals develop these lethal cancers. ..
  2. Photoacoustic endoscopy of Barretts esophagus
    Qifa Zhou; Fiscal Year: 2013
    ....
  3. Familial Barrett's Esophagus
    Amitabh Chak; Fiscal Year: 2011
    ..screening, and genetic analysis methods will now be used to test the following central hypothesis: Familial Barrett Esophagus has a genetic basis...
  4. Clinical Risk Factors for Barretts Esophagus in a Primary Care Setting
    Blair Jobe; Fiscal Year: 2009
    ..The end result will be highly focused risk stratification and prevention or improved survival through early detection. ..
  5. EPIDEMIOLOGY OF BARRETTS ESOPHAGUS
    Thomas Vaughan; Fiscal Year: 2000
    ....
  6. Genetic Etiologies of Esophageal Barrett's and Cancer
    Charis Eng; Fiscal Year: 2003
    ..Despite the accumulation of data regarding the somatic genetics of EAC and Barrett esophagus (BE), the etiology of genetic predisposition to BE and EAC/EGJAC is still unknown...
  7. MUTAGEN SENSITIVITY & PROGRESSION IN BARRETTS ESOPHAGUS
    DIANA FARROW; Fiscal Year: 1999
    ....
  8. Molecular epidemiology of Barretts esophagus and cancer
    David Whiteman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  9. BARRETTS ESOPHAGUS--DIET INTERVENTION/INTERMED MARKERS
    Brian Reid; Fiscal Year: 2001
    ....
  10. STUDIES OF BARRETTS ESOPHAGUS
    Gareth Dulai; Fiscal Year: 2005
    ..The applicant has no comparable source of salary for the proposed period of research and training. ..
  11. EPIDEMIOLOGY OF P16 INACTIVATION IN BARRETTS ESOPHAGUS
    Brian Reid; Fiscal Year: 2000
    ..These results will lead to a better understanding of the relationships between etiologic factors and molecular mechanisms for inactivating a human tumor suppressor gene in a highly fatal cancer in vivo. ..
  12. The Perception of Cancer Risk in Patients with Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2007
    ..The resultant study application will assess health-related quality of life, health-related anxiety and healthcare utilization as outcomes. [unreadable] [unreadable]..
  13. Epidemiologic Case-control Study of Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2005
    ..Finally, by comparing subjects with Barrett's to controls with reflux, and controlling for severs of reflux, the impact of a Barrett's diagnosis on quality of life and psychological stress may be seen. ..
  14. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  15. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  16. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth K Wang; Fiscal Year: 2010
    ..These studies will provide an improved understanding regarding the response of Barrett's esophagus to ablation therapy. ..
  17. Novel Method of Surveillance in Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2008
    ..This is an innovative method by which a physician can diagnose hidden areas of cancer within patients who are at a high risk of developing esophageal cancer. [unreadable] [unreadable] [unreadable]..
  18. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2009
    ..Diagnostic and therapeutic techniques developed in this study can be applied to other gastrointestinal tumors. ..
  19. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2003
    ..The development of a screening device for Barrett's esophagus that could be operated by paramedical personnel would enable large-scale low cost screening to identify patients at risk for esophageal cancer. ..
  20. Epidemiology and Incidence of Barrett's Esophagus
    DOUGLAS ALLEN CORLEY; Fiscal Year: 2010
    ..The proposed study explores how hormones associated with body fat may change the way the body heals after an injury, and increase the risk of cells developing precancerous changes. ..
  21. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2007
    ..In the R33 component of the grant application these criteria will be prospectively evaluated and correlated with clinical outcome in a second, larger cohort of patients. ..
  22. Randomized Trial of EUS Neurolysis in Pancreas Cancer
    Michael Wallace; Fiscal Year: 2006
    ..The primary outcome will be a reduction in pain at 1 month. Secondary outcomes will include the durability of pain control, quality of life, narcotic use and narcotic side effects. [unreadable] [unreadable]..
  23. Predictors of Progression in Barret's Esophagus
    Brian Reid; Fiscal Year: 2001
    ..Successful completion of these aims will provide a scientific basis for i) prevention trials using candidate interventions and validated intermediate endpoints, and ii) a more rational surveillance strategy for BE. ..
  24. MUCIN GLYCOPROTEINS IN COLON CANCER METASTASIS
    Robert S Bresalier; Fiscal Year: 2010
    ..3) Determine the functional mechanism(s) by which galectin-3 modifies expression of MUC2 in colon cancer cells. ..
  25. CHROMOSOME ALTERATIONS IN BARRETT'S ESOPHAGUS
    THOMAS PAULSON; Fiscal Year: 2005
    ..The results from these analyses will be of interest to both clinical and basic researchers in studying EA and other cancers. ..
  26. P53 AND DNA PLOIDY IN BARRETT'S METAPLASIA
    Mamoun Younes; Fiscal Year: 2005
    ..A cost analysis will be then performed to determine whether a molecular based surveillance program would be more cost-effective than current program which is based on morphologic grading of dysplasia. ..
  27. In Vivo Raman Spectroscopy of Barrett's Esophagus
    Louis Michel Wong Kee Song; Fiscal Year: 2005
    ..abstract_text> ..
  28. Advancing an Evidence-Based Approach to Barrett's Esophagus: A Health Outcomes Re
    Chin Hur; Fiscal Year: 2007
    ..We plan to published the proceedings of the meeting and anticipate future project collaborations, grant applications as well as new investigators will arise as a result of this conference. [unreadable] [unreadable] [unreadable]..
  29. Use of Quantitative RT-PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2009
    ..In addition, we believe that this research will answer some very interesting questions about tumor biology and metastasis in esophageal cancer. ..
  30. Adherence and the Economics of Colon Cancer Screening
    John Inadomi; Fiscal Year: 2009
    ..Barriers to screening identified through this study will form the basis of future novel programs to increase CRC screening adherence. ..
  31. Cdx in GI Differentiation and Transdifferentiation
    Debra Silberg; Fiscal Year: 2005
    ..In summary, the overall goal of this project is to elucidate the biological roles of Cdxl and Cdx2 in intestinal metaplasia and the molecular mechanisms of the transdifferentiation program induced by Cdxl and Cdx2. ..
  32. Novel Confocal Microscope for Molecular/Cellular Imaging
    Thomas Wang; Fiscal Year: 2007
    ..7) Collect images from Barrett's epithelium and colonic adenomas during routine endoscopy. ..
  33. Mouse Medel of Esophageal Adenocarcinoma
    XAIOXIN CHEN; Fiscal Year: 2007
    ..This unique model system will lay down a solid foundation for future mechanism-based chemopreventive studies on EAC. [unreadable] [unreadable] [unreadable]..
  34. CORI: Consortium Expansion and Database Enhancement
    David Lieberman; Fiscal Year: 2004
    ....
  35. Screening for colortectal cancer in an Asian Community Center
    David Lieberman; Fiscal Year: 2008
    ..This is a new paradigm for screening, which takes advantage of the trust and cultural awareness that exists at the community center and does not rely on the primary care provider. [unreadable] [unreadable] [unreadable] [unreadable]..
  36. Coherence Imaging for Assessing Colorectal Neoplasia
    Adam Wax; Fiscal Year: 2010
    ..abstract_text> ..
  37. Etiology & pathogenesis of chronic tonsillar hypertrophy
    Zhiheng Pei; Fiscal Year: 2009
    ..Later, we will develop a simple ELISA capable of screening a large number of patients for tonsillar antibodies to the MC-species. Addressing the three aims will provide evidence to examine the hypothesis of a bacterial etiology of CTH. ..
  38. Animal Model of Barrett's Esophagus
    Xiaoxin Chen; Fiscal Year: 2003
    ..Such an animal model would provide a basis for future studies on the mechanism, prevention, and therapy of BE and EAC. ..
  39. Familial Aggregation of Barrett's Esophagus
    Amitabh Chak; Fiscal Year: 2003
    ..They will also define a population at risk in whom interventions to prevent or eradicate Barrett's esophagus can be applied. ..
  40. Pixel-accurate oncologic therapy using a scanning fiber endoscope
    Eric J Seibel; Fiscal Year: 2010
    ..abstract_text> ..
  41. Molecular Mechanisms Underlying Barrett's Esophagus
    Debra Silberg; Fiscal Year: 2003
    ....
  42. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2009
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  43. Barrett's Esophagus Ablation with Celocoxib Trial
    Charles Lightdale; Fiscal Year: 2002
    ..Patients will be accrued during the first study year, and will be followed until the last patient enrolled completes one year of treatment. ..
  44. Targeting Histone Deacetylation: A Tool for Chemopevention of Esophageal Cancer
    Laura Kresty; Fiscal Year: 2008
    ..goal of identifying and translating efficacious preventive agents into the clinic for evaluation in high risk human cohorts, including patients with long standing Barrett's esophagus or [unreadable] [unreadable] [unreadable]..
  45. Polymorphisms in Inflammation Genes and Bladder Cancer Risk
    Jian Gu; Fiscal Year: 2008
    ..The application will allow us to have a comprehensive picture of the effects of functional polymorphisms in inflammation related genes on BC risk. [unreadable] [unreadable] [unreadable]..
  46. Colon Barrier Breakdown in the Elderly
    James Mullin; Fiscal Year: 2005
    ..Changes in membrane composition/fluidity are known to affect paracellular permeability in general, and tight junction proteins specifically. ..
  47. Benzo[alpha]pyrene Diol Epoxide (BPDE) Sensitivity at 9*
    Jian Gu; Fiscal Year: 2005
    ..The proposed susceptibility marker may be useful as biomarkers to identify high-risk populations that could then be targeted for intensive smoking-cessation programs and could be enrolled into chemoprevention trials. ..
  48. Bacterial flora in normal esophagus & reflux disorders
    Zhiheng Pei; Fiscal Year: 2005
    ..ii) While GERD initially results from chemical damage, bacterial overgrowth may promote intestinal metaplasia of the esophagus. The proposed study allows qualitative and quantitative examination of this hypothesis. ..
  49. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  50. EVOLUTIONARY DYNAMICS OF BARRETT'S ESOPHAGUS NEOPLASIA
    Carlo Maley; Fiscal Year: 2005
    ..The challenge of this project is the integration of diverse molecular and epidemiological data into a coherent and detailed understanding of the progression to cancer in the neoplasm of a model system. ..
  51. Chemoprevention of Tobacco-related Oral Carcinogenesis
    Xiaoxin Chen; Fiscal Year: 2005
    ..Some of the agents and biomarkers studied herein may be used for chemoprevention in individuals with leukoplakia and erythroplakia. ..
  52. CatheterScope for Intraluminal Image of Early.Neoplasia
    Eric Seibel; Fiscal Year: 2006
    ..abstract_text> ..
  53. Clinical Significance of Apoptosis in Colon Cancer
    Frank Sinicrope; Fiscal Year: 2006
    ..abstract_text> ..
  54. Assessing nuclear morphology in thick tissues using fLCI
    Adam Wax; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. Studies of Esophageal Metaplasia Using a Novel Antibody
    Kiron Das; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  56. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
  57. Image-guided catheter biopsy of peripheral lung cancer
    Eric Seibel; Fiscal Year: 2005
    ..abstract_text> ..
  58. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2008
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  59. In vivo detection of pre-cancerous lesions using a/LCL
    Adam Wax; Fiscal Year: 2008
    ..abstract_text> ..
  60. Assessing Deployment of Microbicidal Gels With Label-Free Optical Measurement
    Adam Wax; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  61. H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESIS
    Fritz Francois; Fiscal Year: 2008
    ..From these studies, both the microbial contribution and the host genotype contribution to adenocarcinoma risk should be able to be assessed, as well as to begin to define relevant cellular pathways. ..
  62. Cohort Study of Risks for Benign Prostatic Hyperplasia
    Alan Kristal; Fiscal Year: 2005
    ..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..