vasculitis

Summary

Summary: Inflammation of a blood vessel.

Top Publications

  1. doi Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
    David Saadoun
    Université Pierre et Marie Curie Université Paris 06, Paris, France
    N Engl J Med 365:2067-77. 2011
  2. doi Detection of WA B cells in hepatitis C virus infection: a potential prognostic marker for cryoglobulinemic vasculitis and B cell malignancies
    Glenn B Knight
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Arthritis Rheum 62:2152-9. 2010
  3. doi EULAR recommendations for the management of primary small and medium vessel vasculitis
    C Mukhtyar
    University of Oxford, Oxford, UK
    Ann Rheum Dis 68:310-7. 2009
  4. doi Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 112:1620-7. 2008
  5. ncbi Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemic vasculitis: where do we stand?
    P Cacoub
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, France
    Ann Rheum Dis 67:283-7. 2008
  6. pmc Translational mini-review series on immunology of vascular disease: mechanisms of vascular inflammation and remodelling in systemic vasculitis
    N Maugeri
    H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina, Milano, Italy
    Clin Exp Immunol 156:395-404. 2009
  7. ncbi Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations
    Domenico Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Lancet Infect Dis 5:227-36. 2005
  8. doi 18F-FDG PET as a diagnostic procedure in large vessel vasculitis-a controlled, blinded re-examination of routine PET scans
    Petra Lehmann
    Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany
    Clin Rheumatol 30:37-42. 2011
  9. doi Whole-body fluorodeoxyglucose positron emission tomography/computed tomography in patients with active polymyalgia rheumatica: evidence for distinctive bursitis and large-vessel vasculitis
    Hiroyuki Yamashita
    Division of Rheumatic Diseases, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku ku, Tokyo, Japan
    Mod Rheumatol 22:705-11. 2012
  10. doi 11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
    Mingjuan J Luo
    Cardiovascular Disease Department, Merck Research Laboratories, Rahway, NJ, USA
    Physiol Genomics 45:47-57. 2013

Detail Information

Publications432 found, 100 shown here

  1. doi Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
    David Saadoun
    Université Pierre et Marie Curie Université Paris 06, Paris, France
    N Engl J Med 365:2067-77. 2011
    Patients with vasculitis induced by the hepatitis C virus (HCV) have reduced levels of regulatory T cells (Tregs). Resolution of HCV infection correlates with cure of vasculitis and the recovery of Treg levels...
  2. doi Detection of WA B cells in hepatitis C virus infection: a potential prognostic marker for cryoglobulinemic vasculitis and B cell malignancies
    Glenn B Knight
    Lahey Clinic, Burlington, Massachusetts 01805, USA
    Arthritis Rheum 62:2152-9. 2010
    An uncommon manifestation of hepatitis C virus (HCV) infection is systemic vasculitis associated with type II cryoglobulinemia (cryoglobulinemic vasculitis), a proliferative B cell disorder that transforms into B cell malignancy in 5-10% ..
  3. doi EULAR recommendations for the management of primary small and medium vessel vasculitis
    C Mukhtyar
    University of Oxford, Oxford, UK
    Ann Rheum Dis 68:310-7. 2009
    To develop European League Against Rheumatism (EULAR) recommendations for the management of small and medium vessel vasculitis.
  4. doi Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 112:1620-7. 2008
    ..The highest CXCL13 levels strongly correlated with active cutaneous vasculitis. CXCL13 gene expression in portal tracts, isolated from liver biopsy tissues with laser capture microdissection, ..
  5. ncbi Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemic vasculitis: where do we stand?
    P Cacoub
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, France
    Ann Rheum Dis 67:283-7. 2008
    Mixed cryoglobulinemia (MC) vasculitis represents a complication of the B cell response to a variety of chronic inflammatory diseases...
  6. pmc Translational mini-review series on immunology of vascular disease: mechanisms of vascular inflammation and remodelling in systemic vasculitis
    N Maugeri
    H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina, Milano, Italy
    Clin Exp Immunol 156:395-404. 2009
    ..These advances have provided clues to the molecular mechanisms underlying the vicious circle that maintains and amplifies vessel and tissue injury...
  7. ncbi Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations
    Domenico Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Lancet Infect Dis 5:227-36. 2005
    ..C virus (HCV) has been shown to be closely related to mixed cryoglobulinaemia, an immune complex-mediated vasculitis. HCV particles and non-enveloped nucleocapsid protein participate in the formation of immune complexes...
  8. doi 18F-FDG PET as a diagnostic procedure in large vessel vasculitis-a controlled, blinded re-examination of routine PET scans
    Petra Lehmann
    Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany
    Clin Rheumatol 30:37-42. 2011
    Large vessel vasculitis can be visualized by 18F-FDG positron emission tomography (PET). However, the diagnostic value of 18F-FDG PET is yet to be determined...
  9. doi Whole-body fluorodeoxyglucose positron emission tomography/computed tomography in patients with active polymyalgia rheumatica: evidence for distinctive bursitis and large-vessel vasculitis
    Hiroyuki Yamashita
    Division of Rheumatic Diseases, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku ku, Tokyo, Japan
    Mod Rheumatol 22:705-11. 2012
    ....
  10. doi 11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature
    Mingjuan J Luo
    Cardiovascular Disease Department, Merck Research Laboratories, Rahway, NJ, USA
    Physiol Genomics 45:47-57. 2013
    ..Taken together, our data suggest 11β-HSD1 inhibition regulates proinflammatory gene expression in atherosclerotic tissues of ApoE-/- mice, and this effect may contribute to the attenuation of atherosclerosis in these animals...
  11. pmc Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis
    Melanie S Joy
    Division of Nephrology and Hypertension, UNC Kidney Center, University of North Carolina School of Medicine, Chapel Hill, USA
    Br J Clin Pharmacol 74:445-55. 2012
    ..The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide were evaluated. The influence of laboratory and pharmacogenomic covariates on pharmacokinetics was evaluated as a secondary aim...
  12. doi Vasculitis-like syndrome associated with Borrelia lusitaniae infection
    I Lopes de Carvalho
    Center for Vector and Infectious Diseases Research, Instituto Nacional de Saude Dr Ricardo Jorge, Lisbon, Portugal
    Clin Rheumatol 27:1587-91. 2008
    We report the isolation of Borrelia lusitaniae from a 13-year-old female child presenting with a vasculitis syndrome. The patient was treated with doxycycline, 100 mg bid for 20 days, and is in remission after a follow-up of 2 years...
  13. doi Vasculitis
    Carol A Langford
    Center for Vasculitis Care and Research, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH 44195, USA
    J Allergy Clin Immunol 125:S216-25. 2010
    b>Vasculitis is defined by the presence of blood vessel inflammation...
  14. doi Manifestations of chronic hepatitis C virus infection beyond the liver
    Ira M Jacobson
    Center for the Study of Hepatitis C, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Gastroenterol Hepatol 8:1017-29. 2010
    ..Extrahepatic manifestations include mixed cryoglobulinemia (MC) vasculitis, lymphoproliferative disorders, renal disease, insulin resistance, type 2 diabetes, sicca syndrome, rheumatoid ..
  15. ncbi Intravascular glucocorticoid metabolism during inflammation and injury in mice
    Anna R Dover
    Clinical Lecturer, Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, Scotland, UK
    Endocrinology 148:166-72. 2007
    ..We conclude that increased generation of glucocorticoids by 11betaHSD1 in the murine vessel wall is unlikely to contribute to feedback regulation of inflammation...
  16. ncbi Morphologic features and development of granulomatous vasculitis in feline infectious peritonitis
    A Kipar
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, UK
    Vet Pathol 42:321-30. 2005
    ..coronavirus (CoV)-induced systemic disease in cats, characterized by granulomas in organs and granulomatous vasculitis. This study describes the morphologic features of granulomatous vasculitis in FIP as well as its development in ..
  17. doi Kawasaki Disease update
    Jane C Burns
    Department of Pediatrics, UCSD School of Medicine, Rady Children s Hospital, La Jolla, CA 92093, USA
    Indian J Pediatr 76:71-6. 2009
    ..New treatments aimed at modifying the host immune response are currently under study. The genetic influence on susceptibility and disease outcome is an area of active research...
  18. doi Role of imaging studies in the diagnosis and follow-up of large-vessel vasculitis: an update
    N Pipitone
    Rheumatology Department, Arcispedale Santa Maria Nuova, Viale Risorgimento, 80, I 42100 Reggio Emilia, Italy
    Rheumatology (Oxford) 47:403-8. 2008
    ..Imaging procedures can also be used to monitor the disease course. However, imaging signs of inflammation may sometimes persist despite clinical remission and, conversely, seemingly unaffected vessels may develop alterations later on...
  19. doi Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots
    Ziv Shulman
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 13:67-76. 2012
    ..Thus, effector T lymphocytes can cross inflamed barriers through contact-guided consumption of intraendothelial chemokines without surface-deposited chemokines or extraendothelial chemokine gradients...
  20. doi Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells
    Jan H N Lindeman
    Department of Vascular Surgery, K6R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 119:2209-16. 2009
    ..We thus hypothesized that doxycycline acts through an effect on vascular inflammation...
  21. pmc Pulmonary vasculitis
    Kevin K Brown
    Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Am Thorac Soc 3:48-57. 2006
    Pulmonary vasculitis describes a number of distinct disorders that are pathologically characterized by the destruction of blood vessels...
  22. pmc Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis
    Paulo Ricardo Criado
    Department of Dermatology, School of Medicine, Sao Paulo University, Sao Paulo SP, Brazil
    An Bras Dermatol 88:355-60. 2013
    ..We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer...
  23. doi Complement activation is involved in renal damage in human antineutrophil cytoplasmic autoantibody associated pauci-immune vasculitis
    Guang qun Xing
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China
    J Clin Immunol 29:282-91. 2009
    This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis.
  24. ncbi Long-term follow-up of relapsing/refractory anti-neutrophil cytoplasm antibody associated vasculitis treated with the lymphocyte depleting antibody alemtuzumab (CAMPATH-1H)
    M Walsh
    Vasculitis Clinic, Box 118, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Ann Rheum Dis 67:1322-7. 2008
    Lymphocytes are a contributor to the pathogenesis of anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis (AASV). Conventional immunosuppressive therapy is associated with high rates of relapse and toxicity...
  25. doi Usefulness of whole-body fluorine-18-fluorodeoxyglucose positron emission tomography in patients with large-vessel vasculitis: a systematic review
    Giorgio Treglia
    Institute of Nuclear Medicine, Positron Emission Tomography Centre, Catholic University of the Sacred Heart, Largo Gemelli 8, Rome, 00168, Italy
    Clin Rheumatol 30:1265-75. 2011
    ..and PET/computed tomography (PET/CT) with fluorine-18-fluorodeoxyglucose (FDG) in patients with large-vessel vasculitis (LVV)...
  26. doi A novel enzyme-linked immunosorbent assay using a mixture of human native and recombinant proteinase-3 significantly improves the diagnostic potential for antineutrophil cytoplasmic antibody-associated vasculitis
    J Damoiseaux
    Department of Clinical and Experimental Immunology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Ann Rheum Dis 68:228-33. 2009
    Antineutrophil cytoplasmic antibodies (ANCA) with a C-ANCA or P-ANCA pattern are detected in ANCA-associated vasculitis (AAV)...
  27. doi The impact of 18F-FDG PET on the management of patients with suspected large vessel vasculitis
    Martin Fuchs
    Institute of Nuclear Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
    Eur J Nucl Med Mol Imaging 39:344-53. 2012
    We aimed to assess the impact of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the management of patients with suspected large vessel vasculitis.
  28. doi De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure
    L G Hidalgo
    Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 9:2532-41. 2009
    ..We propose careful assessment of de novo DSA, particularly against class II, be performed in all late kidney transplant biopsies...
  29. ncbi Long-term observation of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis treated with rituximab
    R Stasi
    Department of Medical Sciences, Regina Apostolorum Hospital, Via San Francesco, 50, 00041 Albano Laziale, Italy
    Rheumatology (Oxford) 45:1432-6. 2006
    ..We prospectively studied the long-term effects of rituximab in 10 patients with anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis refractory to conventional therapy (n=3) or in second or subsequent relapse (n=7).
  30. ncbi Increase of circulating neutrophil and platelet microparticles during acute vasculitis and hemodialysis
    L Daniel
    Department of Pathology, CHU Timone and EA 3281, IFR 125, Faculty of Medicine, Marseille, France
    Kidney Int 69:1416-23. 2006
    ..They are here investigated in common nephropathies including vasculitis and dialysis, two conditions characterized by neutrophil activation...
  31. ncbi Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis
    Alexander Woywodt
    Division of Nephrology, Department of Medicine, Hannover Medical School, 30625, Hannover, Germany
    Lancet 361:206-10. 2003
    Histological findings in small-vessel vasculitis associated with antineutrophil cytoplasmic antibodies (ANCAs) suggest that damaged endothelial cells undergo necrosis and detachment from the basement membrane...
  32. pmc Magnetic resonance angiography in extracranial giant cell arteritis
    Marcel Koenigkam-Santos
    Department of Radiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    J Clin Rheumatol 17:306-10. 2011
    ..Noninvasive diagnosis of giant cell arteritis (GCA) remains challenging, particularly with regard to evaluation of extracranial arterial disease...
  33. ncbi Evaluation of the FIDIS vasculitis multiplex immunoassay for diagnosis and follow-up of ANCA-associated vasculitis and Goodpasture's disease
    J Damoiseaux
    Department of Clinical and Experimental Immunology, University Hospital Maastricht, The Netherlands
    Ann N Y Acad Sci 1109:454-63. 2007
    We have evaluated a new-multiplex immunoassay (FIDIS Vasculitis) for simultaneous detection and quantification of anti-MPO, -PR3, and -glomerular basement membrane (GBM) antibodies in diagnosis and follow-up of ANCA-associated ..
  34. doi Modification and validation of the Birmingham Vasculitis Activity Score (version 3)
    C Mukhtyar
    University of Oxford, Oxford OX3 7LD, UK
    Ann Rheum Dis 68:1827-32. 2009
    Comprehensive multisystem clinical assessment using the Birmingham Vasculitis Activity score (BVAS) is widely used in therapeutic studies of systemic vasculitis. Extensive use suggested a need to revise the instrument...
  35. doi Follow-up of avidity and titer of anti-myeloperoxidase antibodies in sera from patients with primary ANCA-associated vasculitis
    Wei Lin
    Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Ministry of Health of China, Beijing, People s Republic of China
    Autoimmunity 42:198-202. 2009
    Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV)...
  36. doi Involvement of the heart by small and medium vessel vasculitis
    Garvan C Kane
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Curr Opin Rheumatol 21:29-34. 2009
    The heart may be involved in many different ways by the systemic vasculitides. In this review, we focus on recently described diagnostic and therapeutic issues in small and medium vessel vasculitis of the heart.
  37. ncbi The antineutrophil cytoplasmic antibody-associated vasculitides
    Philip Seo
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med 117:39-50. 2004
    ..Distinguishing the ANCA-associated vasculitides from other forms of vasculitis or nonvasculitic processes (such as infection) can be particularly difficult...
  38. ncbi Tumor necrosis factor-alpha blockade and the risk of vasculitis
    Loic Guillevin
    J Rheumatol 31:1885-7. 2004
  39. ncbi Plasmapheresis therapy for diffuse alveolar hemorrhage in patients with small-vessel vasculitis
    Philip J Klemmer
    Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill 27599 7155, USA
    Am J Kidney Dis 42:1149-53. 2003
    Unlike Goodpasture's syndrome with diffuse alveolar hemorrhage (DAH), there are few studies examining therapy for patients with DAH associated with antineutrophil cytoplasmic antibody (ANCA)-associated small-vessel vasculitis (SVV).
  40. doi Evaluation of a multiplex flow cytometric immunoassay to detect PR3- and MPO-ANCA in active and treated vasculitis, and in inflammatory bowel disease (IBD)
    Michelle Trevisin
    Pathology Department, Austin Health, Heidelberg, VIC 3084, Australia
    J Immunol Methods 336:104-12. 2008
    ..Sera were from patients with active (n=55) or treated (n=68) small vessel vasculitis, or inflammatory bowel disease (IBD, n=22)...
  41. ncbi Sjögren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Medicine (Baltimore) 84:81-9. 2005
    ..presented a systemic process with diverse extraglandular manifestations, with articular involvement (44%), vasculitis (20%), and neuropathy (16%) being the most frequent features observed...
  42. doi Vasculitis in children and adolescents: clinical presentation, etiopathogenesis, and treatment
    Kjell Tullus
    Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    Paediatr Drugs 11:375-80. 2009
    ..KD is the most common vasculitis in infants and the development of coronary artery aneurysms is the major complication...
  43. ncbi Clinical and histologic determinants of renal outcome in ANCA-associated vasculitis: A prospective analysis of 100 patients with severe renal involvement
    Robert A F de Lind van Wijngaarden
    Leiden University Medical Center, Department of Pathology, Postbus 9600, 2300 RC Leiden, The Netherlands
    J Am Soc Nephrol 17:2264-74. 2006
    ..to identify clinical and histologic prognostic indicators of renal outcome in patients with ANCA-associated vasculitis and severe renal involvement (serum creatinine >500 micromol/L)...
  44. ncbi [Vasculitis and vasculopathy]
    Asjastipić Marković
    Sveti Duh University Hospital, Department of Clinical Immunology, Pulmonology and Rheumatology, Zagreb, Croatia
    Acta Med Croatica 66:19-24. 2012
    ..b>Vasculitis denotes a heterogeneous group of clinical entities which all are characterized by the inflammatory process of ..
  45. ncbi ANCA-associated vasculitis: diagnostic and therapeutic strategy
    Shoichi Ozaki
    Division of Rheumatology and Allergy, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    Allergol Int 56:87-96. 2007
    ..granulomatosis (WG), and allergic granulomatous angiitis (AGA) are known collectively as ANCA-associated vasculitis (AAV) because of the involvement of anti-neutrophil cytoplasmic antibodies (ANCA) as the common pathogenesis...
  46. doi Paraneoplastic vasculitis and paraneoplastic vascular syndromes
    Gionata Buggiani
    University Unit of Dermatology, University of Florence School of Medicine, Florence, Italy
    Dermatol Ther 23:597-605. 2010
    ..migrant thrombophlebitis and blood hypercoagulability can be seen, whereas in case of hematological neoplasms, vasculitis, and erythromelalgia can occur...
  47. doi The surgical pathology of pulmonary infarcts: diagnostic confusion with granulomatous disease, vasculitis, and neoplasia
    Samuel A Yousem
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    Mod Pathol 22:679-85. 2009
    ....
  48. doi Management of noninfectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique des Hopitaux de Paris, Universite Pierre et Marie Curie, 47 83 boulevard de l Hopital, Paris, France
    Blood 119:5996-6004. 2012
    Data on the clinical spectrum and therapeutic management of noninfectious mixed cryoglobulinemia vasculitis (CryoVas) in the era of hepatitis C virus screening are lacking...
  49. pmc Characteristic purpura of the ears, vasculitis, and neutropenia--a potential public health epidemic associated with levamisole-adulterated cocaine
    Catherine Chung
    University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Am Acad Dermatol 65:722-5. 2011
    ..Levamisole-induced vasculitis and neutropenia has been reported elsewhere in the United States and Canada...
  50. pmc Comparison of disease activity measures for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis
    P A Merkel
    Vasculitis Center, E5, Boston University School of Medicine, 72 East Concord Street, Boston, Massachussets, 02118, USA
    Ann Rheum Dis 68:103-6. 2009
    ..disease activity and extent in clinical trials of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, leading to division among investigative groups and difficulty comparing study results...
  51. ncbi Epidemiology of systemic vasculitis
    Suzanne E Lane
    Ipswich Hospital NHS Trust, Heath Rd, Ipswich, IP4 5PD, UK
    Curr Rheumatol Rep 7:270-5. 2005
    ..No definite trigger factors have been found, but KD has been linked to infection, house dust mite and chemicals, and Henoch-Schonlein purpura to a pesticide and drugs...
  52. ncbi The infectious etiology of vasculitis
    Merav Lidar
    Center for Autoimmune Diseases, Rheumatology Unit, Sheba Medical Center SMC, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Autoimmunity 42:432-8. 2009
    ..in mixed cryoglobulinemia is clearly established, evidence for the association of other infectious agents with vasculitis, including human immunodeficiency virus, parvovirus B19, cytomegalovirus, varicella zoster virus, Staphylococcus ..
  53. doi Chronic periaortitis: a large-vessel vasculitis?
    Augusto Vaglio
    Department of Clinical Medicine and Nephrology, University Hospital of Parma, Italy
    Curr Opin Rheumatol 23:1-6. 2011
    ..This article reviews the issue of large-vessel involvement in chronic periaortitis and its implications in the pathogenesis and nosography of the disease...
  54. ncbi Silica exposure in anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and lupus nephritis
    S L Hogan
    Department of Medicine, The University of North Carolina at Chapel Hill, 27599-7155, USA
    J Am Soc Nephrol 12:134-42. 2001
    Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated small-vessel vasculitis (SVV) and systemic lupus erythematosus (SLE) are rare diseases with unknown causes...
  55. pmc Prognostic factors for hospital mortality and ICU admission in patients with ANCA-related pulmonary vasculitis
    Fernando Holguin
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Med Sci 336:321-6. 2008
    The objective of this study was to evaluate the factors predictive of 28-day mortality and admission to Intensive Care Unit (ICU) in patients with ANCA-related pulmonary vasculitis.
  56. ncbi Hepatitis C virus-associated extrahepatic manifestations: a review
    Damien Sene
    Department of Internal Medicine, Boulevard de l Hopital, Paris, France
    Metab Brain Dis 19:357-81. 2004
    ..The other diseases include noncryoglobulinemic systemic vasculitis, splenic lymphoma with villous lymphocytes, fatigue, porphyria cutanea tarda, sicca syndrome, and autoantibodies ..
  57. pmc Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 110:955-63. 2002
    ..80% of patients with pauci-immune necrotizing and crescentic glomerulonephritis and systemic small vessel vasculitis, such as microscopic polyangiitis and Wegener granulomatosis...
  58. pmc Levamisole-induced occlusive necrotizing vasculitis of the ears after use of cocaine contaminated with levamisole
    Jennie A Buchanan
    Department of Emergency Medicine, Denver Health and Hospital Authority, 777 Bannock St MC 0108, Denver, CO, USA
    J Med Toxicol 7:83-4. 2011
    ..susceptible to fulminate and opportunistic infections and also can cause a debilitating cutaneous necrotizing vasculitis. In this manuscript, we describe a case and provide an image of levamisole-induced necrotizing vasculitis of the ..
  59. ncbi Serial ANCA determinations for monitoring disease activity in patients with ANCA-associated vasculitis: systematic review
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Am J Kidney Dis 47:15-23. 2006
    ..Studies using serial ANCA monitoring in patients with ANCA-associated vasculitis (AASV) have yielded controversial results during the last 15 years...
  60. pmc Effects of duration of glucocorticoid therapy on relapse rate in antineutrophil cytoplasmic antibody-associated vasculitis: A meta-analysis
    Michael Walsh
    Addenbrooke s Hospital, Cambridge, UK
    Arthritis Care Res (Hoboken) 62:1166-73. 2010
    Disease relapses are common for patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). The role of low-dose glucocorticoids (GC) in relapse prevention is controversial...
  61. doi When to suspect pulmonary vasculitis: radiologic and clinical clues
    Eva Castañer
    Department of Radiology, SDI UDIAT CD, Institut Universitari Parc Tauli UAB, Corporacio Parc Tauli, Parc Tauli s n, Sabadell, Spain
    Radiographics 30:33-53. 2010
    b>Vasculitis is an inflammatory destructive process affecting blood vessels. Pulmonary vasculitis may be secondary to other conditions or constitute a primary, and in most cases idiopathic, disorder...
  62. doi Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity
    Kuninobu Wakabayashi
    Division of Rheumatology, Department of Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Mod Rheumatol 22:59-65. 2012
    ..to be an important mediator in several inflammatory disorders, including rheumatoid arthritis (RA) and vasculitis. To evaluate the role of MIF in rheumatoid vasculitis (RV), we determined serum levels of MIF by enzyme-linked ..
  63. pmc Nomenclature and classification of vasculitis: lessons learned from granulomatosis with polyangiitis (Wegener's granulomatosis)
    J C Jennette
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, USA
    Clin Exp Immunol 164:7-10. 2011
    ..This term also is in accord with the name for a closely related vasculitis, i.e. microscopic polyangiitis...
  64. pmc Occult hepatitis C virus infection revisited with ultrasensitive real-time PCR assay
    Philippe Halfon
    Laboratoire Alphabio, 23 Rue de Friedland, Hopital Ambroise Pare, 13006 Marseille, France
    J Clin Microbiol 46:2106-8. 2008
    ..infection cannot be found in peripheral blood mononuclear cells of patients with cryptogenic liver diseases, HCV--associated systemic vasculitis, or connective tissue diseases. The significance of such occult infection must be elucidated.
  65. ncbi Malignancy is increased in ANCA-associated vasculitis
    T Pankhurst
    Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, UK
    Rheumatology (Oxford) 43:1532-5. 2004
    In the light of previous reports of an association between malignancy and renal vasculitis, we aimed to investigate the association of malignancy in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, either Wegener's ..
  66. ncbi Cutaneous vasculitis in primary Sjögren syndrome: classification and clinical significance of 52 patients
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Medicine (Baltimore) 83:96-106. 2004
    To analyze the different clinical and histologic types of cutaneous vasculitis in patients with primary Sjögren syndrome (SS), we investigated the clinical and immunologic characteristics of 558 consecutive patients with primary SS from ..
  67. doi Antineutrophil cytoplasmic autoantibody-associated vasculitis in older patients
    Min Chen
    Department of Medicine, Peking University First Hospital, Beijing, China
    Medicine (Baltimore) 87:203-9. 2008
    Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is increasingly recognized in older patients. The differences in disease presentation and outcome between older and younger patients remain controversial...
  68. doi Surrogate markers of B cell non-Hodgkin's lymphoma in patients with hepatitis C virus-related cryoglobulinaemia vasculitis
    Guillaume Geri
    Service de Médecine Interne II, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Ann Rheum Dis 69:2177-80. 2010
    To evaluate clinical and biological surrogate markers associated with the presence of B cell non-Hodgkin's lymphoma (B-NHL) in patients with hepatitis C virus (HCV) with mixed cryoglobulinaemia (MC) vasculitis.
  69. pmc Thromboembolic disease in vasculitis
    Gunnar Tomasson
    The Vasculitis Center, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
    Curr Opin Rheumatol 21:41-6. 2009
    To give an overview of recent clinical findings of thromboembolic disease in vasculitis and provide insight into possible explanations of the association between thrombosis and inflammation.
  70. doi Intracellular cytokine production in ANCA-associated vasculitis: low levels of interleukin-10 in remission are associated with a higher relapse rate in the long-term follow-up
    Zdenka Hruskova
    Department of Nephrology, 1st Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic
    Arch Med Res 40:276-84. 2009
    ..response likely plays a role in the pathogenesis of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV), but it has not yet been fully established...
  71. ncbi Alpha-melanocyte stimulating hormone prevents lipopolysaccharide-induced vasculitis by down-regulating endothelial cell adhesion molecule expression
    T E Scholzen
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, 48149 Munster, Germany
    Endocrinology 144:360-70. 2003
    ..Importantly in vivo, in murine LPS-induced cutaneous vasculitis (local Shwartzman reaction), a single ip injection of alpha-MSH significantly suppressed the deleterious ..
  72. doi Infliximab efficacy and safety against refractory systemic necrotising vasculitides: long-term follow-up of 15 patients
    L Josselin
    Department of Internal Medicine, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Ann Rheum Dis 67:1343-6. 2008
    ..However, its safety and ability to induce and maintain remission over the long term remain unknown...
  73. ncbi Sustained exacerbation of cryoglobulinaemia-related vasculitis following treatment of hepatitis C with peginterferon alfa
    Dominique Batisse
    Service d immunologie clinique, Hopital Europeen Georges Pompidou, Paris, France
    Eur J Gastroenterol Hepatol 16:701-3. 2004
    ..with HCV-related cirrhosis and cryoglobulinaemia who presented with an acute and long-lasting exacerbation of vasculitis during treatment with peginterferon...
  74. ncbi Cutaneous sinus histiocytosis (Rosai-Dorfman disease) presenting clinically as vasculitis
    Catherine M Stefanato
    Dermatopathology Section, Boston University School of Medicine and Department of Dermatology, MA, USA
    J Am Acad Dermatol 46:775-8. 2002
    ..into pruritic papulopetechial and purpuric lesions on the back and lower extremities, diagnosed clinically as a vasculitis. The patient's lesions cleared spontaneously with no recurrence...
  75. pmc Pathogenesis of antineutrophil cytoplasmic autoantibody vasculitis
    J Charles Jennette
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7525, USA
    Curr Opin Nephrol Hypertens 20:263-70. 2011
    Antineutrophil cytoplasmic autoantibodies (ANCAs) are associated with vasculitis. Current therapy involves administration of toxic therapy that is not optimally effective...
  76. ncbi Histopathological features of murine systemic vasculitis caused by Candida albicans extract--an animal model of Kawasaki disease
    K Takahashi
    Department of Pathology, Ohashi Hospital, Toho University School of Medicine, 2 17 6, Ohashi, Meguro, Tokyo, 153 8515, Japan
    Inflamm Res 53:72-7. 2004
    We examined the histopathological features of systemic vasculitis caused in mice by injection of a Candida albicans ( C. albicans) extract and investigated the principal genetic roles in the development of vasculitis.
  77. pmc Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission
    S Ohlsson
    Department of Nephrology, Lund University Hospital, Lund, Sweden
    Clin Exp Immunol 131:528-35. 2003
    ..PR3 was significantly raised (P < 0.0001) in vasculitis patients (median 560 micro g/l, range 110-3,940, n = 59) compared with healthy blood donors (350 micro g/l, 110-..
  78. doi The histological assessment of cutaneous vasculitis
    J Andrew Carlson
    Department of Pathology, Divisions of Dermatology and Dermatopathology, Albany Medical College, Albany, NY, USA
    Histopathology 56:3-23. 2010
    b>Vasculitis is defined as inflammation directed at vessels, which compromises or destroys the vessel wall leading to haemorrhagic and/or ischaemic events...
  79. doi Progress in pediatric vasculitis
    KATHLEEN M O'NEIL
    Division of Pediatric Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Curr Opin Rheumatol 21:538-46. 2009
    To examine recent advances in the pathophysiology and therapy of pediatric vasculitis.
  80. ncbi Treatment of refractory Churg-Strauss-Syndrome (CSS) by TNF-alpha blockade
    Olga Arbach
    Clinic for Rheumatology, University of Luebeck, Luebeck, Germany
    Immunobiology 206:496-501. 2002
    ..The BVAS 1 markedly improved after additional treatment with TNF-alpha blockers...
  81. ncbi Microscopic polyangiitis presenting as a "pulmonary-muscle" syndrome: is subclinical alveolar hemorrhage the mechanism of pulmonary fibrosis?
    Julius Birnbaum
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 56:2065-71. 2007
    ..Identification of vasculitis on muscle biopsy was instrumental in recognizing clinical, radiographic, and histopathologic features that were ..
  82. ncbi Predominance of type 1 (Th1) cytokine production in the liver of patients with HCV-associated mixed cryoglobulinemia vasculitis
    David Saadoun
    Service de Medecine Interne, Hopital Pitie Salpetriere, 47 bd de l Hopital, 75013 Paris, France
    J Hepatol 41:1031-7. 2004
    Patients with hepatitis C virus (HCV) mixed cryoglobulinemia (MC) vasculitis have a higher mortality rate and more frequent incidence of cirrhosis than their cryoglobulin-negative counterparts...
  83. pmc High-mobility group box-1 protein (HMGB1) is increased in antineutrophilic cytoplasmatic antibody (ANCA)-associated vasculitis with renal manifestations
    Annette Bruchfeld
    Department of Renal Medicine, Karolinska Institute, Stockholm, Sweden
    Mol Med 17:29-35. 2011
    ..In antineutrophilic cytoplasmatic antibody (ANCA)-associated vasculitis (AAV), the kidneys are commonly affected vital organs, characterized by focal necrotizing and/or crescentic ..
  84. doi A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis
    Rachel B Jones
    Renal Unit, Addenbrooke s Hospital, Cambridge, UK
    Arthritis Rheum 60:2156-68. 2009
    ..has allowed remissions in relapsing or refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in small studies...
  85. ncbi Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial
    Kirsten de Groot
    Klinikum Offenbach, Offenbach, Germany
    Ann Intern Med 150:670-80. 2009
    Current therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis are limited by toxicity.
  86. doi Azathioprine or methotrexate maintenance for ANCA-associated vasculitis
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 359:2790-803. 2008
    ..However, azathioprine and methotrexate have not been compared with regard to safety and efficacy...
  87. doi Antiendothelial cells autoantibodies in vasculitis-associated systemic diseases
    Philippe Guilpain
    Faculty of Medicine, Paris Descartes University, UPRES EA, Paris, France
    Clin Rev Allergy Immunol 35:59-65. 2008
    ..AECA might contribute to the pathogenesis of systemic vasculitides and vasculitis-associated diseases through (1) activation of endothelial cells (EC), (2) direct cytotoxic effect due to ..
  88. ncbi Cytomegalovirus vasculitis and mucormycosis coinfection in late-stage HIV/AIDS
    Jyoti S Samant
    Department of Internal Medicine, Section of Infectious Diseases, Mercer University, School of Medicine, Macon, Georgia 31201, USA
    Am J Med Sci 333:122-4. 2007
    ..We describe the first case of CMV vasculitis and mucormycosis coinfection resulting in necrotizing myofascial cellulitis in an extremity in late stage HIV/..
  89. pmc Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis
    Mark A Little
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Am J Pathol 174:1212-20. 2009
    The morbidity burden associated with anti-neutrophil cytoplasmic autoantibody-associated vasculitis is increasing, and many novel biological therapies are now entering the drug development pipeline...
  90. ncbi Pulmonary manifestations of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis
    D R Thickett
    Lung Injury and Fibrosis Treatment Programme, Department of Medical Sciences, Division of Infection and Immunity, Medical School, University of Birmingham, Birmingham, UK
    Rheumatology (Oxford) 45:261-8. 2006
  91. ncbi Establishment of a pilot pediatric registry for chronic vasculitis is both essential and feasible: a Childhood Arthritis and Rheumatology Alliance (CARRA) survey
    Nicholas M R Wilkinson
    Division of Rheumatology, Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada
    J Rheumatol 34:224-6. 2007
    To identify the need for, and feasibility of, establishing a web-based USA/Canadian registry of children with chronic systemic vasculitis--an otherwise insufficiently studied population.
  92. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
    ..Our results indicate that platelets are not only involved in haemostasis but that they also directly initiate an inflammatory response of the vessel wall...
  93. ncbi Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a systematic review
    Xavier Bosch
    Department of Internal Medicine, Hospital Clinic, Barcelona, Spain
    JAMA 298:655-69. 2007
    Immunosuppressive therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis have greatly advanced patient survival but have turned ANCA-associated vasculitis (AAV) into chronic, relapsing disorders...
  94. doi Renal vasculitis in Japan and the UK--are there differences in epidemiology and clinical phenotype?
    Richard A Watts
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    Nephrol Dial Transplant 23:3928-31. 2008
    The epidemiology of renal vasculitis in different populations is poorly understood...
  95. ncbi Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice
    Niels R Veillard
    Division Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
    Circ Res 94:253-61. 2004
    ..Thus, our findings indicate that blockade of chemokine receptor/ligand interactions might become a novel therapeutic strategy to reduce the evolution of this common disease...
  96. ncbi A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis
    V Witko-Sarsat
    Institut National de la Santé et de la Recherche Médicale U507 and Department of Nephrology, Necker Hospital, Paris, France
    J Am Soc Nephrol 10:1224-33. 1999
    ..The frequency of the mPR3high phenotype was significantly increased in patients with ANCA-associated vasculitis (85% versus 55% in healthy subjects)...
  97. ncbi Anti-tumor necrosis factor-alpha therapy-induced vasculitis: case series
    Stephen J Jarrett
    Academic Unit of Musculoskeletal Medicine, University of Leeds, Great George Street, Leeds LS1 3EX, United Kingdom
    J Rheumatol 30:2287-91. 2003
    ..We describe eight patients with rheumatoid arthritis treated with anti-TNF therapies who developed presumed vasculitis, with different pathophysiologic causes...
  98. ncbi Hepatitis C-associated mixed cryoglobulinaemia: a crossroad between autoimmunity and lymphoproliferation
    D Saadoun
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, France
    Rheumatology (Oxford) 46:1234-42. 2007
    ..mixed cryoglobulins (MCs) are detected in 40-60% of HCV-infected patients whereas overt cryoglobulinaemia vasculitis develops in only 5-10% of the cases...
  99. ncbi Epidemiology of the vasculitides
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Rheum Dis Clin North Am 27:729-49. 2001
    ..Although the causes of vasculitis are largely unknown, epidemiologic studies have implicated geographic, genetic, and environmental factors...
  100. pmc Expression profiling of PBMC-based diagnostic gene markers isolated from vasculitis patients
    Shigeto Kobayashi
    Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    DNA Res 15:253-65. 2008
    b>Vasculitis (angiitis) is a systemic autoimmune disease that often causes fatal symptoms. We aimed to isolate cDNA markers that would be useful for diagnosing not only vasculitis but also other autoimmune diseases...
  101. pmc Netting neutrophils in autoimmune small-vessel vasculitis
    Kai Kessenbrock
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Nat Med 15:623-5. 2009
    Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs)...

Research Grants65

  1. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Serpin Modulation of Inflammatory Vasculitis;Potential for Immunomodulatory Therapy The broad challenge areas applicable for this research proposal are 1) 15-OD(ORDR)-101* Pilot projects for ..
  2. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..literature to a wide spectrum of diseases in human and veterinary medicine, including polyarthritis, cutaneous vasculitis, endocarditis, myocarditis, epistaxis, peliosis hepatis, granulomatous inflammatory disease, and, most recently, ..
  3. Anti- IL5 therapy for Churg-Strauss Syndrome: a double blind randomized, placebo-
    Michael E Wechsler; Fiscal Year: 2010
    ..CSS) is a complex syndrome associated with asthma, anti-neutrophil cytoplasmic antibodies, and eosinophilic vasculitis involving multiple organs including the lungs, heart, skin, gastrointestinal tract, and nervous system...
  4. White matter changes in HIV models
    Pamela E Knapp; Fiscal Year: 2011
    ..Myelin pallor" is an anomaly consistently reported in HIV patients. It was historically attributed to vasculitis and subsequent blood brain barrier leakage...
  5. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..Rac proteins, 4) define a role for Mac-1 in triggering neutrophil elastase release and subsequent hemorrhagic vasculitis in vivo, through activation of the src and syk kinases, and 5) demonstrate a critical role for Mac-1 on ..
  6. Mechanism of Neutrophil Activation
    Kenneth R McLeish; Fiscal Year: 2013
    ..participate in a number of diseases prominent in the aging Veteran population, including ANCA-associated vasculitis, ischemia- reperfusion injury, acute respiratory distress syndrome, rheumatoid arthritis, peridontitis, ..
  7. Translational studies of the Platelet Specific Receptor Trem Like Transcript (TLT
    A Valance Washington; Fiscal Year: 2013
    ..neutrophil migration, higher basal neutrophil counts and hemorrhage in response to the Shwartzman model of vasculitis. These phenotypic similarities suggest that TLT-1 function complements that of p-selectin...
  8. B cell metabolism in activation and autoantibody production
    Jeffrey C Rathmell; Fiscal Year: 2013
    ..a variety of SLE-associated pathologies, including immune complex formation and deposition responsible for vasculitis and glomerulonephritis, many therapeutic approaches to treat SLE have targeted B cell survival or function...
  9. Neutrophil Migration in Three Dimensions
    Jonathan S Reichner; Fiscal Year: 2013
    ..damage such as respiratory distress syndrome, asthma, inflammatory bowel disease, ischemia/reperfusion injury, vasculitis and rheumatoid arthritis...
  10. Reverse genetics to develop a second generation Rift Valley fever vaccine
    Tetsuro Ikegami; Fiscal Year: 2013
    ..A proportion of infected humans develop hemorrhagic fever, encephalitis or retinal vasculitis;the offspring of infected ruminants often die in utero...
  11. Development of a Novel Rift Valley Fever Virus Vaccine
    Shinji Makino; Fiscal Year: 2013
    ..are infected concurrently, and their infection results in hemorrhagic fever, encephalitis, and retinal vasculitis. Many different mosquitoes, including several native to North America, are competent vectors for RVFV epidemic ..
  12. RCT of GnRH-a for ovarian protection during CYC therapy for rheumatic disease
    WILLIAM J MC CUNE; Fiscal Year: 2012
    ..severe rheumatic diseases including lupus nephritis, Wegener's granulomatosis, other forms of pauci-immune vasculitis, and severe interstitial lung disease complicating scleroderma will be entered into the trial...
  13. control of Inflammation by regulatory T cells and BCL6
    Alexander L Dent; Fiscal Year: 2012
    ..regulatory mediator of T-reg activity can offer new insights into the molecular etiology of myocarditis and vasculitis, thus facilitating the development of new therapies targeting BCL6 for treatment of inflammation and ..
  14. Host Cell JAK-STAT Activation and Pathogenesis of Spotted Fever Rickettsioses
    Sanjeev K Sahni; Fiscal Year: 2012
    ..by acquisition of prothrombotic, procoagulant and proinflammatory phenotypes, manifesting as 'rickettsial vasculitis'...
  15. The role of Burkholderia in giant cell arteritis
    Curry Koening; Fiscal Year: 2013
    ..the blood of subjects with GCA and whether it can induce the formation of multinucleated giant cells and cause vasculitis in a humanized-mouse chimeric model...
  16. Urinary Biomarkers of Chronic Kidney Disease Pathology and Progression
    Sushrut S Waikar; Fiscal Year: 2013
    ..2) A kidney biopsy biospecimens bank of IgA nephropathy, lupus nephritis, renal vasculitis, and Chinese herbal nephropathy from our established collaboration with Peking University First Hospital (PUFH) ..
  17. Anti IL5 and Churg Strauss Syndrome: a double blind, placebo controlled trial
    Michael E Wechsler; Fiscal Year: 2013
    ..Churg-Strauss syndrome (CSS) is a complex syndrome characterized by asthma, eosinophilic inflammation, and vasculitis involving multiple organs, including the lungs, heart, skin, gastrointestinal tract, and nervous system...
  18. IDENTIFICATION AND VALIDATION OF BIOMARKERS FOR VASCULITIS
    Paul A Monach; Fiscal Year: 2010
    ..AAV) survive, but subsequent disease course is variable, relapse is common, and long-term morbidity from vasculitis or its treatment is expected...
  19. Phase III infliximab for primary treatment of Kawasaki disease IND 11046 6/27/200
    Jane C Burns; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Kawasaki disease (KD, OMIM 300530) is a self-limited vasculitis that is the leading cause of acquired heart disease in children in the U.S. and Japan (Taubert et al. 1991)...
  20. Impact of TNFa blockade on immune function in acute Kawasaki disease
    ALESSANDRA I FRANCO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): KD is an acute vasculitis of unknown etiology that is the leading cause of acquired heart disease in children in the United States and Japan...
  21. CARRA: Accelerating Toward an Evidence Based Culture in Pediatric Rheumatology
    Carol A Wallace; Fiscal Year: 2010
    ..for the major pediatric rheumatic diseases, (juvenile arthritis, systemic lupus, dermatomyositis, scleroderma, vasculitis, and pain syndromes) and support standardization of treatment protocols, clinical trials, observational disease ..
  22. Identifying Vulnerable Plaque in Rheumatoid Arthritis
    Kimberly P Liang; Fiscal Year: 2013
    ..presenting and publishing work in the areas of premature atherosclerosis in the rheumatic diseases as well as in vasculitis. Her short- and long-term career goals include becoming proficient in the novel CU imaging technique as a means ..
  23. Role of Interferon-gamma in Viral Reactivation and Vasculitis
    SUSAN PRISCILLA CANNY; Fiscal Year: 2013
    ..broad implications for understanding the pathogenesis of cardiovascular diseases, including atherosclerosis and vasculitis. While the etiologies of many vasculitides are unknown, there is epidemiologic evidence for an infectious ..
  24. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald J Falk; Fiscal Year: 2013
    Glomerulonephritis and vasculitis caused by anti-neutrophil cytoplasmic autoantibodies (ANCA) Is the most common form of rapidly progressive glomerular disease...
  25. LFA-1 in Lymphocyte Migration
    Minsoo Kim; Fiscal Year: 2013
    ..immune responses, leukocyte migration is also involved in a wide range of pathologic conditions including vasculitis, atherosclerosis, stroke, rheumatoid arthritis, lupus, multiple sclerosis and Crohn's disease...
  26. Molecular mechanisms of the impact of Fli-1 on lupus
    Xian Zhang; Fiscal Year: 2013
    ..Fli-1 on lupus Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by arthritis, vasculitis, immune complex glomerulonephritis and infiltration of inflammation cells into the glomeruli...
  27. Innate Immune Mechanisms and TLRs in Bacterial Ligand-Induced Arteritis
    Moshe Arditi; Fiscal Year: 2012
    ..Kawasaki Disease is a vasculitis involving children and results in over 20% incidence of developing coronary arteritis and aneurysms...
  28. TRAINING IN CELL STRUCTURE AND FUNCTION IN NEPHROLOGY
    M Amin Arnaout; Fiscal Year: 2013
    ..are applied to nine research themes that are relevant to diseases such as diabetes, hypertension, nephritis, vasculitis and polycystic kidney disease...
  29. Pro-inflammatory S100A12 in atherosclerosis and acute coronary syndrome
    MARION A HOFMANN-BOWMAN; Fiscal Year: 2012
    ..serum S100A12 concentrations are present in patients with chronic inflammatory diseases including patients with vasculitis such as Kawasaki disease and in diabetic patients...
  30. Potential Role of IL-1B Therapies for Treatment of Vasculitis of Kawasaki Disease
    Moshe Arditi; Fiscal Year: 2013
    ..provided by applicant): Kawasaki disease (KD) is the most common cause of acquired cardiac disease and acute vasculitis in children in the developed world. The pathogenesis and molecular mechanisms are still unclear...
  31. GENE MAPPING IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS
    Kathy L Moser; Fiscal Year: 2010
    ..Erythematosus (SLE) is characterized by widespread immune activation and autoantibody production, leading to vasculitis and systemic end-organ damage...
  32. Novel Proteomic Arrays of In Vitro Expressed Proteins for Autoimmune Disease
    Mark Lim; Fiscal Year: 2009
    ..Similar studies will be carried out on other vasculitis autoimmune diseases in association with Dr. Peter Merkel, Director of the Vasculitis Research Consortium...
  33. Plasma Exchange and Glucocorticoids for Treatment of ANCA-Associated Vasculitis
    Peter A Merkel; Fiscal Year: 2011
    ..S.), multi-system diseases commonly referred to as anti-neutrophil cytoplasm antibody (ANCA) -associated vasculitis (AAV). AAV, although rare, is almost universally fatal if left untreated...
  34. Using genomics to elucidate the pathogenesis of granulomatosis with polyangiitis
    SHARON ALANE CHUNG; Fiscal Year: 2013
    ..is establishing herself as a translational investigator conducting patient-oriented genomic studies of systemic vasculitis. In this proposal, Dr...
  35. The Pathogenesis of Autoimmunity in Hepatitis C Virus Infection
    Edgar D Charles; Fiscal Year: 2012
    ..MC affects up to 50% of HCV patients, causing a small-vessel vasculitis. HCV MC is clearly a risk factor for the development of B cell non- Hodgkin lymphoma...
  36. Improving Assessment of Physical Function and Drug Safety in Health and Disease
    Eswar Krishnan; Fiscal Year: 2013
    ..2. To validate these domains in rheumatoid arthritis, osteoarthritis, lupus, scleroderma, juvenile arthritis, vasculitis, and gout patients, in frailty/aging, nursing home, and positive health populations, as well as populations that ..
  37. Young Investigator Travel Awards: 15th International Vasculitis and ANCA Workshop
    Charles Jennette; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The 15th International Vasculitis and ANCA Workshop will be held Sunday, May 15 through Wednesday, May 18, 2011 in Chapel Hill, North Carolina...
  38. CORE CENTER
    Antony Rosen; Fiscal Year: 2013
    ..Fred Wigley), lupus (Dr. Michelle Petri), arthritis (Dr. Joan Bathon), and vasculitis (Dr. John Stone). These clinical cohorts are coupled closely with a robust basic science program directed by Drs...
  39. Role of gammaHV68 M1 antigen in Vbeta4+ T cell expansion and fibrosis
    Samuel H Speck; Fiscal Year: 2012
    ..This immune-mediated pathology consists of multi-organ fibrotic tissue damage and vasculitis, associated with chronic reactivation of latent virus and persistent replication...
  40. Inflammation in Vascular Injury and Repair
    Daniel I Simon; Fiscal Year: 2013
    ..new discoveries that the Mac-1-GP Iba interaction broadly regulates inflammation in models of thrombosis, vasculitis, glomerulonephritis, and multiple sclerosis...
  41. GENETIC LINKAGE IN LUPUS
    JOHN BARKER HARLEY; Fiscal Year: 2013
    ..severe, causing nephritis, oral ulcers, arthritis, pericarditis, pleuritis, rashes, strokes, heart attacks, vasculitis, nervous dysfunction, cytopenias, Raynaud's disease, and immune dysfunction...
  42. MONONUCLEAR PHAGOCYTE FUNCTION IN IMMUNOLOGIC DISEASES
    Robert P Kimberly; Fiscal Year: 2010
    ..for the gamma-chain associated receptors, to determine their functional characteristics and to establish their association with altered host defense and autoimmune disease (eg, rheumatoid arthritis, celiac disease, systemic vasculitis).
  43. Vasculitis Clinical Research Consortium
    Peter A Merkel; Fiscal Year: 2013
    The Vasculitis Clinical Research Consortium (VCRC) was established in 2003 and in 5 years of rapid growth and productivity has become the major clinical research infrastructure in North America dedicated to the study of vasculitis...
  44. Molecular Etiology of Familial Mediterranean Fever
    Deborah Gumucio; Fiscal Year: 2007
    ..Occasionally, this disease presents with skin manifestations (erysipeloid erythema), pericarditis, vasculitis, or myalgia. In many patients, amyloidosis is a complication, and if untreated, this can be life-threatening...
  45. Autoimmunity in Rag Deficiency: A Nexus of Immunodeficiency and Dysregulation
    Jolan E Walter; Fiscal Year: 2013
    ..late onset granulomatous disease associated with autoimmunity (from mild cytopenias to localized destructive vasculitis)...
  46. Molecular Targeting of Plaque Angiogenesis in Diabetes
    KAREN SIMPSON MOULTON; Fiscal Year: 2012
    ..vessels;however, these vessels proliferate and invade the intima during atherosclerosis and other conditions of vasculitis. Increasing data suggests that the permeability, inflammatory cell recruitment and bleeding properties of plaque ..
  47. Novel Methods for the Conduct of Clinical Trials
    Peter A Merkel; Fiscal Year: 2013
    ..The research will be conducted by the Vasculitis Clinical Research Consortium, a multi-center clinical research infrastructure sponsored by the NIH...
  48. CONCURRENT PILOT STUDIES IN GIANT CELL ARTERITIS AND TAKAYASUS ARTERITIS TO EXAM
    Avery Gottfried; Fiscal Year: 2011
    ..TAK are diseases that share a number of common features and are both characterized by blood vessel inflammation (vasculitis) that can be serious or even life threatening...
  49. ENDOTHELIAL CELL AUTOIMMUNITY IN DIABETIC RETINOPATHY
    Ramesh Nayak; Fiscal Year: 2001
    ..as a candidate antigen based on published studies showing that anti-endothelial cell autoantibodies in systemic vasculitis also specifically bind to monocytes but not other cell types tested and that 50 percent of diabetic sera react ..
  50. Adaption and Validation of PROMIS for use in Vasculitis
    Peter A Merkel; Fiscal Year: 2013
    ..into the assessment of disease activity and burden among patients with ANCA-associated vasculitis [AAV, granulomatosis with polyangiitis (Wegener's), microscopic polyangiitis, and Churg-Strauss syndrome]...
  51. RISK SCORE FOR CORONARY ANEURYSMS IN KAWASAKI SYNDROME
    Jane Newburger; Fiscal Year: 1992
    Kawasaki syndrome is an acute vasculitis of infancy and childhood which results in coronary artery lesions in 15 to 25% of affected children...
  52. Genetic Polymorphisms in Rheumatoid Arthritis
    Eric Matteson; Fiscal Year: 2004
    ..ExRA), such as pericarditis, pleuritis, interstitial lung disease, Felty's syndrome, scleritis, keratitis, and vasculitis including mononeuritis multiplex as well as vasculitis involvement of internal organs, and the central nervous ..
  53. ROLE OF ANTI-PROTEINASE-3 IN WEGENER'S VASCULOPATHY
    Judith James; Fiscal Year: 2003
    ..WG) is a multisystem disease of unknown etiology which is characterized by small to medium vessel vasculitis, pauci-immune glomerulonephritis, necrosis/granuloma formation of the respiratory tracts and autoantibodies to ..
  54. Genetic influences and T-cell activation in Kawasaki Disease
    Jane Burns; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Kawasaki disease (KD) is a self-limited, acute vasculitis that is the most common cause of pediatric acquired heart disease...
  55. ROLE OF COMPLEMENT FACTOR B IN THE PATHOGENESIS OF SLE
    Gary Gilkeson; Fiscal Year: 2004
    ..mice developed significantly less proteinuria, pathologic renal disease, glomerular IgG immune deposits and vasculitis. Surprisingly, C3 levels were normal in the MRL/lpr Bf deficient mice in contrast to significantly, depressed ..
  56. HEPATITIS C AND CRYOGLOBULINEMIA
    Warren Schmidt; Fiscal Year: 1999
    ..extrahepatic complication of chronic HCV infection and causes a variety of systemic diseases such as arthritis, vasculitis, and glomerulonephritis...
  57. Non-Invasive Approaches to Assessing Inflammation (RMI)
    RYAN SARTOR; Fiscal Year: 2006
    ..arthritis, diabetes, inflammatory bowel diseases, systemic lupus erythematosus (SLE), glomerulonephritis, vasculitis, atherosclerosis and asthma, a major impediment to their diagnosis and clinical management is the inability to ..
  58. ANTIBODY INDUCED HEARING LOSS--MODEL FOR IMMUNE DEAFNESS
    Thomas Carey; Fiscal Year: 1999
    ..sudden or rapidly progressive onset of hearing loss, vestibular involvement, or systemic immune disease, such as vasculitis, might be of autoimmune origin...
  59. NEUTROPHIL/ENDOTHELIAL CELL COMMUNICATION
    Gregory Vercellotti; Fiscal Year: 1993
    ..leukostasis and extended these findings to suggest the pathophysiology underlying shock ("shock lung") and vasculitis. In addition to neutrophil-mediated lytic and denuding endothelial injury, variety of sublytic endothelial ..
  60. AUTOMATED, QUANTITATIVE IMMUNOFLUORESCENT ASSAY
    KENNETH NEWTON; Fiscal Year: 2003
    ..IFA tests detecting Anti-Neutrophil Cytoplasmic Autoantibodies (ANCA) are diagnostic for systemic necrotizing vasculitis and glomerulonephritis...
  61. PET AND MRI IMAGING OF PERSISTENT LYME ENCEPHALOPATHY
    Brian Fallon; Fiscal Year: 2003
    ..These scans are often interpreted as consistent with vasculitis, multi-infarct dementia, or Lyme Disease...
  62. PATHOGENESIS OF COCAETHYLENE-INDUCED VASCULITIS
    DANYEL TACKER; Fiscal Year: 2004
    b>Vasculitis is a common pathological outcome in cocaine addicts, 80% of whom co-abuse cocaine and ethanol...
  63. Genetic Association in American Blacks with Lupus
    John Harley; Fiscal Year: 2009
    ..severe organ injury (nephritis, ulcers, arthritis, pericarditis, pleuritis, rashes, strokes, heart attacks, vasculitis, nervous dysfunction, cytopenias, Raynaud's disease, and immune dysfunction)...
  64. ROLE OF THE SELECTIONS IN THE DEVELOPMENT OF VASCULITIS
    Daniel Bullard; Fiscal Year: 2001
    The inflammatory events which lead to the development of vasculitis in diseases such as lupus erythematosis, Wegener's granulomatosis, and vasculitic disorders are poorly understood...
  65. Impact of Fli-1 expression on lupus disease development
    Xian Zhang; Fiscal Year: 2007
    Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by arthritis, vasculitis, immune complex glomerulonephritis and infiltration of inflammation cells into the glomeruli...