Genomes and Genes
Summary: Enlarged and tortuous VEINS.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications315 found, 100 shown here
- Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veinsL H Rasmussen
Danish Vein Centres, Naestved, Denmark
Br J Surg 98:1079-87. 2011..This randomized trial compared four treatments for varicose great saphenous veins (GSVs)...
- Endovenous obliteration versus conventional stripping operation in the treatment of primary varicose veins: a randomized controlled trial with comparison of the costsTero Rautio
Department of Surgery, Oulu University Hospital, Kajaanintie 50, SF 90230 Oulu, Finland
J Vasc Surg 35:958-65. 2002....
- Occurrence of CCSVI in patients with MS and its relationship with iron metabolism and varicose veinsP J van den Berg
Department of Neurology, St Elisabeth Hospital, Tilburg, The Netherlands
Eur J Neurol 20:519-26. 2013..A new treatable venous disorder, chronic cerebrospinal venous insufficiency (CCSVI), has been proposed in patients with multiple sclerosis (MS). Its relationship with iron metabolism is suggested, but has not been examined prospectively...
- A systematic review and meta-analysis of the treatments of varicose veinsM Hassan Murad
Knowledge and Evaluation Research Unit, Division of Preventive Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
J Vasc Surg 53:49S-65S. 2011Several treatment options exist for varicose veins. In this review we summarize the available evidence derived from comparative studies about the relative safety and efficacy of these treatments.
- Prolonged standing at work and hospitalisation due to varicose veins: a 12 year prospective study of the Danish populationF Tuchsen
Department of Surveillance and Epidemiology, National Institute of Occupational Health, Copenhagen Ø, Denmark
Occup Environ Med 62:847-50. 2005Recent studies suggest that prolonged standing at work is associated with the development of diseases of varicose veins (VV).
- Endovenous therapies of lower extremity varicosities: a meta-analysisRenate van den Bos
Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands
J Vasc Surg 49:230-9. 2009..These therapies have not yet been compared with surgical ligation and stripping in large randomized clinical trials...
- Radiofrequency endovenous ClosureFAST versus laser ablation for the treatment of great saphenous reflux: a multicenter, single-blinded, randomized study (RECOVERY study)Jose I Almeida
Miami Vein Center, 1501 South Miami Avenue, Miami, FL 33129, USA
J Vasc Interv Radiol 20:752-9. 2009....
- Pathogenesis of primary varicose veinsC S Lim
Imperial Vascular Unit, Imperial College London, 4 East, Charing Cross Hospital, Fulham Palace Road, London, UK
Br J Surg 96:1231-42. 2009Valvular incompetence and reflux are common features of primary varicose veins, and have long been thought to be their cause. Recent evidence, however, suggests that changes in the vein wall may precede valvular dysfunction.
- The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous ForumPeter Gloviczki
Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
J Vasc Surg 53:2S-48S. 2011..and the American Venous Forum (AVF) have developed clinical practice guidelines for the care of patients with varicose veins of the lower limbs and pelvis...
- Randomized clinical trial of radiofrequency ablation or conventional high ligation and stripping for great saphenous varicose veinsS Subramonia
Department of General Surgery, King s Mill Hospital, Mansfield, UK
Br J Surg 97:328-36. 2010This randomized clinical trial compared early outcomes after radiofrequency ablation (RFA) and conventional surgery for varicose veins.
- The epidemiology of chronic venous insufficiency and varicose veinsJennifer L Beebe-Dimmer
Department of Epidemiology, School of Public Health, Division of Venous Disease University of Michigan, Ann Arbor, Michigan 48109, USA
Ann Epidemiol 15:175-84. 2005..English language, from 1942 to the present, and focuses on the prevalence of chronic venous insufficiency and varicose veins, as well as the involved risk factors...
- Pathogenesis of varicose veinsRahmi Oklu
Division of Vascular Imaging and Intervention, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, 290 Gray Bigelow, Boston, MA 02114, USA
J Vasc Interv Radiol 23:33-9; quiz 40. 2012Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain...
- Prevalence, risk factors, and clinical patterns of chronic venous disorders of lower limbs: a population-based study in FrancePatrick H Carpentier
University Research Center of La Léchère, Grenoble, France
J Vasc Surg 40:650-9. 2004The goals of this study were to document the prevalence of varicose veins, skin trophic changes, and venous symptoms in a sample of the general population of France, to document their main risk factors, and to assess relationships between ..
- Diagnosis of small-bowel varices by capsule endoscopyShou Jiang Tang
Center for Therapeutic Endoscopy and Endoscopic, Oncology, St Michael s Hospital, University of Toronto, Ontario, Canada
Gastrointest Endosc 60:129-35. 2004..Capsule endoscopy is being used increasingly to investigate GI bleeding of obscure origin and disorders of the small bowel...
- Varicose veins and their managementBruce Campbell
Royal Devon and Exeter Hospital and Peninsula Medical School, Exeter EX2 5DW
BMJ 333:287-92. 2006
- Inhibitory effect of TIMP influences the morphology of varicose veinsB Aravind
Department of Surgery and Cancer, Faculty of Medicine, Imperial College, and Department of Histopathology, Charing Cross Hospital, London, UK
Eur J Vasc Endovasc Surg 40:754-65. 2010..of matrix metalloproteinase enzymes (MMP) and their inhibitors (TIMPs) may contribute to the development of varicose veins. We hypothesised that, histological changes in varicose vein wall correlate with alterations in expression of ..
- Randomized clinical trial of VNUS ClosureFAST radiofrequency ablation versus laser for varicose veinsA C Shepherd
Imperial Vascular Unit, Department of Surgery, Division of Surgery and Cancer, Imperial College, Charing Cross Hospital, London, UK
Br J Surg 97:810-8. 2010..radiofrequency ablation (RFA) are both associated with excellent technical, clinical and patient-reported outcomes for the treatment of varicose veins. The aim of this study was to compare the techniques in a randomized clinical trial.
- Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veinsArda Kucukguven
Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Curr Drug Targets 14:287-324. 2013b>Varicose veins (VVs) are a common venous disease of the lower extremity characterized by incompetent valves, venous reflux, and dilated and tortuous veins...
- Evaluation of transforming growth factor-beta signaling pathway in the wall of normal and varicose veinsRadoslaw Kowalewski
Department of Vascular Surgery and Transplantology, Medical University of Bialystok, PL 15 276 Bialystok, Poland
Pathobiology 77:1-6. 2010..The aim of the study was to assess the TGF-beta signaling pathway including its receptor (TGF-beta RII) and phosphorylated receptor-regulated Smads (p-Smad2/3) in varicose veins.
- Randomised clinical trial, observational study and assessment of cost-effectiveness of the treatment of varicose veins (REACTIV trial)J A Michaels
Academic Vascular Unit, University of Sheffield, UK
Health Technol Assess 10:1-196, iii-iv. 2006To establish the cost-effectiveness of surgery and sclerotherapy for the treatment of varicose veins.
- Radiofrequency endovenous obliteration versus stripping of the long saphenous vein in the management of primary varicose veins: 3-year outcome of a randomized studyJukka Perälä
Department of Radiology, Oulu University Hospital, Oulu, Finland
Ann Vasc Surg 19:669-72. 2005We evaluated the 3-year outcome of a series of patients with primary varicose veins who were randomized to radiofrequency endovenous obliteration vs. stripping of the long saphenous vein (LSV)...
- Enteroscopic cyanoacrylate sclerotherapy of jejunal and gallbladder varices in a patient with portal hypertensionS Getzlaff
Dept. of Gastroenterology, City Hospital, Ludwigshafen am Rhein (University of Mainz Medical School, Germany
Endoscopy 33:462-4. 2001..No clinical signs of gastrointestinal bleeding were observed during a follow-up period of seven months...
- Technical review of endovenous laser therapy for varicose veinsR R van den Bos
Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands
Eur J Vasc Endovasc Surg 35:88-95. 2008In the last decade, several new treatments of truncal varicose veins have been introduced...
- Initial experiences in endovenous treatment of saphenous vein refluxJohannes E M Sybrandy
Department of Vascular Surgery, Sint Franciscus Hospital, Kleiweg 500, 3045 PM Rotterdam, The Netherlands
J Vasc Surg 36:1207-12. 2002..morbidity, which are also cosmetically more acceptable, has resulted in the endovenous treatment for primary varicose veins, developed by VNUS Medical Technologies, Inc (Sunnyvale, Calif)...
- Treatment of recurrent varicose veins of the great saphenous vein by conventional surgery and endovenous laser ablationLaura van Groenendael
Department of Surgery, Division of Vascular Surgery, Alysis Zorggroep, Location Rijnstate, Arnhem, The Netherlands
J Vasc Surg 50:1106-13. 2009..The aim of the study was to assess feasibility of endovenous laser ablation (EVLA) in recurrent varicose veins of the GSV and to compare this technique with conventional surgical reintervention.
- Outcomes of elective surgery undertaken in independent sector treatment centres and NHS providers in England: audit of patient outcomes in surgeryJ Chard
Clinical Effectiveness Unit, Royal College of Surgeons of England, London WC2A 3PE, UK
BMJ 343:d6404. 2011..To compare characteristics of patients and outcomes after elective surgery in independent sector treatment centres (ISTCs) and NHS providers...
- Great saphenous vein radiofrequency ablation versus standard stripping in the management of primary varicose veins-a randomized clinical trialKhaled Helmy ElKaffas
Department of Radiodiagnosis, Cairo University, Egypt
Angiology 62:49-54. 2011..Chronic venous insufficiency is the most common vascular disease in the adult population. However, randomized clinical trials (RCTs) comparing therapeutic options are limited...
- Effect of portal hypertension in the small bowel: an endoscopic approachPedro Figueiredo
Department of Gastroenterology, Hospitais da Universidade de Coimbra, Coimbra, Portugal
Dig Dis Sci 53:2144-50. 2008..The effects of portal hypertension in the small bowel are largely unknown. The aim of the study was to prospectively assess portal hypertension manifestations in the small bowel...
- Mutations in FOXC2 are strongly associated with primary valve failure in veins of the lower limbRussell H Mellor
Cardiac and Vascular Sciences, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
Circulation 115:1912-20. 2007..cause lymphedema distichiasis, an inherited primary lymphedema in which a significant number of patients have varicose veins. Because lymphedema distichiasis is believed to be caused by lymphatic valve failure (reflux), and FOXC2 is ..
- Lifestyle factors and the risk of varicose veins: Edinburgh Vein StudyAmanda J Lee
Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, United Kingdom
J Clin Epidemiol 56:171-9. 2003..of this study was to determine the inter-relationships between a range of lifestyle factors and risk of varicose veins to identify which factors may be implicated in the etiology...
- Smooth muscle cell modulation and cytokine overproduction in varicose veins. An in situ studyC Badier-Commander
INSERM U460, UFR X Bichat, 16 rue H Huchard, 75870 Paris Cedex 18, France
J Pathol 193:398-407. 2001..of the present work was to study, in situ, the morphology and composition of cellular and matrix components in varicose veins compared with control veins and to identify factors that could contribute to varicose remodelling...
- Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veinsJoseph D Raffetto
VA Boston Healthcare System, West Roxbury, Mass, USA
J Vasc Surg 48:447-56. 2008Increased venous hydrostatic pressure plays a role in the pathogenesis of varicose veins. Increased expression of matrix metalloproteinases (MMPs) has been identified in varicose veins...
- Mathematical coupling may account for the association between baseline severity and minimally important difference valuesJohn Patrick Browne
Health Services Research Unit, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
J Clin Epidemiol 63:865-74. 2010....
- Endovenous laser treatment for uncomplicated varicose veinsR J Darwood
Leeds Vascular Institute, The General Infirmary at Leeds, Leeds, UK
Phlebology 24:50-61. 2009..of incompetent truncal veins has been proposed as a minimally invasive alternative to conventional surgery for varicose veins. Various strategies have been proposed for successful treatment and this study reviews the evidence for these.
- Neurovascular compression of the common peroneal nerve by varicose veinsN Yamamoto
Department of Surgery, Hamaoka Municipal Hospital, 2060 Ikesinnden, Hamaoka, Shizuoka, Japan 437 1696
Eur J Vasc Endovasc Surg 28:335-8. 2004Compression of the common peroneal nerve occurs sometimes, but compression caused by varicose veins has not been reported before. We report a case of common peroneal nerve compression syndrome which was confirmed and treated surgically...
- Sclerotherapy treatment of telangiectasias and varicose veinsSteven E Zimmet
Zimmet Vein and Dermatology Clinic, Austin, TX 78701, USA
Tech Vasc Interv Radiol 6:116-20. 2003Telangiectasias and/or varicose veins are present in about 33% of adult women and 15% of adult men...
- Minimally invasive techniques in the treatment of saphenous varicose veinsTamar Nijsten
Department of Dermatology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
J Am Acad Dermatol 60:110-9. 2009..Dermatologists have played an important role in the development of these new therapies of truncal varicose veins. Of the new therapies, ultrasound-guided foam sclerotherapy, endovenous laser therapy, and radiofrequency ..
- Epidemiological study on varicose veins in BudapestI Bihari
Semmelweis University, Budapest Hungary
Phlebology 27:77-81. 2012To analyse the prevalence and risk factors of varicose veins and chronic venous disease in Budapest.
- Microfoam ultrasound-guided sclerotherapy treatment for varicose veins in a subgroup with diameters at the junction of 10 mm or greater compared with a subgroup of less than 10 mmJohn M Barrett
Palm Clinic, Auckland, New Zealand
Dermatol Surg 30:1386-90. 2004....
- Cost-effectiveness of traditional and endovenous treatments for varicose veinsM S Gohel
Imperial Vascular Unit, Charing Cross Hospital, London, UK
Br J Surg 97:1815-23. 2010The aim of this study was to evaluate the cost-effectiveness of traditional and endovenous treatments for patients with primary great saphenous varicose veins.
- Imaging mass spectrometry reveals unique lipid distribution in primary varicose veinsH Tanaka
Division of Vascular Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu 431 3192, Japan
Eur J Vasc Endovasc Surg 40:657-63. 2010The lipid metabolism of varicose veins (VVs) remains unknown. To elucidate the pathogenesis of VV, we utilized the novel technique of imaging mass spectrometry (IMS).
- Surgical management of varicose veins: meta-analysisRanjeet Brar
St George s Vascular Institute, St George s Hospital, London, UK
Vascular 18:205-20. 2010..randomized controlled trials reviews the current evidence base, comparing open and endovascular treatment of varicose veins. Systematic review of studies reporting duplex scan follow-up after open surgical, laser (endovenous laser ..
- Patterns of saphenous reflux in women with primary varicose veinsCarlos Alberto Engelhorn
Santa Casa de Misericordia, Pontificia Universidade Catolica do Parana, Brazil
J Vasc Surg 41:645-51. 2005b>Varicose veins have been linked to great saphenous vein (GSV) reflux and in particular, with reflux at the saphenofemoral junction (SFJ)...
- Foam sclerotherapy--a possible option in therapy of varicose veinsMichael Kendler
Department of Dermatology, Venereology and Allergy, University of Leipzig, Germany
J Dtsch Dermatol Ges 5:648-54. 2007The therapy of varicose veins is multimodal and depends on the individual clinical findings...
- Comparing endovenous laser ablation, foam sclerotherapy, and conventional surgery for great saphenous varicose veinsAnke A M Biemans
Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands
J Vasc Surg 58:727-34.e1. 2013Many case series have been published on treatments of varicose veins, but comparative randomized controlled trials remain sparse.
- Endovenous laser: a new minimally invasive method of treatment for varicose veins--preliminary observations using an 810 nm diode laserL Navarro
Vein Treatment Center and Beth Israel Medical Center, New York, New York 10021, USA
Dermatol Surg 27:117-22. 2001..Minimally invasive alternatives in the treatment of varicose veins with SFJ and GSV incompetence have been tried over the years to increase patient comfort, reduce cost and risk,..
- Hemorrhoids and varicose veins: a review of treatment optionsD Mackay
Thorne Research, 4616 SE 30th, Portland, OR 97202, USA
Altern Med Rev 6:126-40. 2001Hemorrhoids and varicose veins are common conditions seen by general practitioners. Both conditions have several treatment modalities for the physician to choose from. Varicose veins are treated with mechanical compression stockings...
- Structural changes in the tunica intima of varicose veins: a histopathological and ultrastructural studyA A Khan
Department of Anatomy, College of Medicine and Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia
Pathology 32:253-7. 2000Many factors have been implicated in the aetiology of varicose veins; however, there is ample evidence implicating that the defect is in the wall of the lower limb veins...
- Quantitative proteomics analysis of varicose veins: identification of a set of differentially expressed proteins related to ATP generation and utilizationChao Jen Kuo
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan Center for Research Resources and Development, Kaohsiung Medical University, Kaohsiung, Taiwan
Kaohsiung J Med Sci 29:594-605. 2013Although morphological and anatomical studies indicate that varicose veins are characterized by venous wall weakening and subendothelial fibrosis, the exact underlying biochemical mechanism of their development remains unknown...
- Management of varicose veins and venous insufficiencyAllen Hamdan
Department of Surgery, Beth Israel Deaconess Medical Center, 110 Francis St, Boston, Massachusetts 02215, USA
JAMA 308:2612-21. 2012..by a spectrum of signs and symptoms, including cosmetic spider veins, asymptomatic varicosities, large painful varicose veins, edema, hyperpigmentation and lipodermatosclerosis of skin, and ulceration...
- Comparison of collagen subtype I and III presence in varicose and non-varicose vein wallsZ Haviarova
Institute of Anatomy, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Bratisl Lek Listy 109:102-5. 2008..The connective tissue alterations in varicose vein wall are supposed to be one of the main causes of primary varicose vein (main sign of human lower limbs chronic venous insufficency)...
- Histopathological changes in the wall of varicose veinsM A Wali
Department of Surgery, Asir Central Hospital and College of Medicine, King Khalid University, Abha, Saudi Arabia
Int Angiol 22:188-93. 2003Vein wall distensibility is controlled by collagen, elastin and smooth muscle cells. However, contradicting evidence exists on the connective tissue concentration and smooth muscle pathology in varicose veins.
- Varicose veins are a risk factor for deep venous thrombosis in general practice patientsUwe Müller-Bühl
Department of General Practice and Health Services Research, University Hospital, Heidelberg, Germany
Vasa 41:360-5. 2012The role of varicose veins (VV) as a risk factor for development of deep venous thrombosis (DVT) is still controversial...
- Mechanisms of increased vascular superoxide production in human varicose veinsBartłomiej Guzik
Department of Internal and Agricultural Medicine, Jagiellonian University, Medical College, Krakow, Poland
Pol Arch Med Wewn 121:279-86. 2011..Recent studies have shown that oxidative stress is increased in varicose veins (VV) and venous insufficiency. However, the exact mechanisms of oxidative stress in VV remain unknown.
- Injection of polidocanol foam (PF) in varicose veins as a trigger for attacks of migraine with visual auraH Ratinahirana
Cephalalgia 23:850-1. 2003
- Recurrent varicose veins: incidence, risk factors and groin anatomyL Blomgren
Department of Surgery, St Gorans Hospital, Stockholm
Eur J Vasc Endovasc Surg 27:269-74. 2004..the recurrence rate after sapheno-femoral junction (SFJ) ligation and great saphenous vein (GSV) stripping for varicose veins (VV), to evaluate risk factors for recurrence and to classify the anatomy of the recurrence in the groin...
- Preliminary experience with a new sclerosing foam in the treatment of varicose veinsL Tessari
Glauco Bassi Foundation, Trieste, Italy
Dermatol Surg 27:58-60. 2001..We present a pilot study of a new technique for producing the sclerosing foam (Tessari's method) (SFT) and its use in sclerotherapy of major and minor varicosities...
- Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veinsD Carradice
Academic Vascular Surgical Unit, University of Hull, Hull, UK
Br J Surg 98:1117-23. 2011This report describes the clinical effectiveness and recurrence rates from a randomized trial of endovenous laser ablation (EVLA) and surgery for varicose veins.
- Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veinsP Sansilvestri-Morel
Division of Angiology, Servier Research Institute, Suresnes, France
J Vasc Res 38:560-8. 2001b>Varicose veins have a thickening wall. Their smooth muscle cells are disorganized as regards proliferation and production of extracellular matrix protein...
- Venous hypoxia: a poorly studied etiological factor of varicose veinsC S Lim
Imperial Vascular Unit, Department of Surgery and Cancer, Faculty of Medicine, Charing Cross Hospital, Imperial College London, London, UK
J Vasc Res 48:185-94. 2011..There was no evidence that differences exist between oxygen content of blood from varicose and non-varicose veins, although the former demonstrated larger fluctuations with postural changes...
- Identification of differentially expressed genes in human varicose veins: involvement of matrix gla protein in extracellular matrix remodelingChrystelle Cario-Toumaniantz
INSERM, U533, Universite de Nantes, Faculte des Sciences et Techniques, l institut du thorax, Nantes, France
J Vasc Res 44:444-59. 2007This study was designed to identify the global pattern of differentially expressed genes in human varicose veins. Using suppressive subtractive hybridization, we identified overexpression of genes known to be associated with extracellular ..
- Pain following 980-nm endovenous laser ablation and segmental radiofrequency ablation for varicose veins: a prospective observational studyAmanda C Shepherd
Imperial Vascular Unit, Imperial College, Charing Cross Hospital, London, United Kingdom
Vasc Endovascular Surg 44:212-6. 2010..The aim of this study was to evaluate postoperative pain following endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) and identify risk factors for increased pain...
- [New advances in the treatment of varicose veins: endovenous radiofrequency VNUS Closure®]Cesar Garcia-Madrid
Angiologia, Cirugia Vascular y Endovascular, Institut Vascular Sala Planell Centro Médico Teknon, Barcelona, Espana
Cir Esp 89:420-6. 2011Lower limb varicose veins are often secondary to greater saphenous vein (GSV) insufficiency. Technological development has led to the appearance of new minimally invasive treatments, such as endovenous radiofrequency ablation (ERFA)...
- Standing at work and varicose veinsF Tuchsen
Department of Surveillance and Epidemiology, National Institute of Occupational Health, Copenhagen, Denmark
Scand J Work Environ Health 26:414-20. 2000This study attempts to determine whether or not prolonged standing at work involves an excess risk for the occurrence of varicose veins.
- Overexpression of transforming growth factor-beta1 correlates with increased synthesis of nitric oxide synthase in varicose veinsTheresa Jacob
Division of Vascular Surgery, Maimonides Medical Center, 4802 10th Avenue, Brooklyn, NY 11219, USA
J Vasc Surg 41:523-30. 2005..inducible nitric oxide synthase (iNOS) mediates signal transduction in vascular wall during the development of varicose veins. Currently, we investigated the expression and correlation of TGF-beta 1 , iNOS, monocyte/macrophage ..
- Persistent sciatic vessels, varicose veins, and lower limb hypertrophy: an unusual case or discrete clinical syndrome?Duncan J Parry
Department of Vascular Surgery, Huddersfield Royal Infirmary
J Vasc Surg 36:396-400. 2002..We present the case of a 27-year-old woman with atypical left-sided varicose veins and soft tissue hypertrophy. Imaging showed persistence of both sciatic artery and vein...
- In vitro differences between smooth muscle cells derived from varicose veins and normal veinsYing Xiao
Research Center of Vascular Surgery, Department of Vascular Surgery, First Affiliated Hospital of Sun Yat sen University, Guangzhou, Peoples Republic of China
J Vasc Surg 50:1149-54. 2009..many studies have investigated the role of the main components of the venous wall in the development of varicose veins, the leading cause remains unknown...
- A prospective randomised controlled trial of VNUS closure versus surgery for the treatment of recurrent long saphenous varicose veinsR J Hinchliffe
Department of Vascular and Endovascular Surgery, University Hospital, Nottingham, UK
Eur J Vasc Endovasc Surg 31:212-8. 2006This study aimed to assess the outcome of endoluminal thermal ablation (VNUS) and traditional redo groin surgery (RGS) and long saphenous vein (LSV) stripping in patients with bilateral recurrent long saphenous varicose veins.
- Bloodstain pattern analysis in a case of fatal varicose vein ruptureAnny Sauvageau
Laboratoire de Sciences Judiciaires et de Médecine Légale, Montreal, Quebec, Canada
Am J Forensic Med Pathol 28:35-7. 2007..Until now, the bloodstain patterns in these fatal cases have not been described. An examination of the bloodstain pattern in a case of fatal varicose vein rupture in an 84-year-old man is here reported...
- Role of the endothelium and blood stasis in the development of varicose veinsC Michiels
Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium
Int Angiol 21:18-25. 2002..Additionally, the mechanism of the occurrence of varicose veins is not understood...
- Whole-leg duplex mapping for varicose veins: observations on patterns of reflux in recurrent and primary legs, with clinical correlationJ K F Wong
Department of General Surgery, Raigmore Hospital, Inverness, Scotland
Eur J Vasc Endovasc Surg 25:267-75. 2003..the variability of venous reflux patterns complicate the management of venous disease. Our study investigates specific variations in venous anatomy and patterns of reflux in varying clinical situations...
- Radiofrequency ablation for uncomplicated varicose veinsM S Gohel
Imperial Vascular Unit, Charing Cross Hospital, London W6 8RF, UK
Phlebology 24:42-9. 2009..The scientific principles behind RFA and technical procedural considerations are discussed and standards of care for the delivery of endovenous RFA are proposed...
- The incidence and characteristic features of fatal hemorrhage due to ruptured varicose veins: a 10-year autopsy studyRoger W Byard
Forensic Science SA, Adelaide, Australia
Am J Forensic Med Pathol 28:299-302. 2007Death due to hemorrhage from ruptured peripheral varicose veins is an uncommon event...
- Neovascularization and recurrent varicose veins: more histologic and ultrasound evidenceAndre M Van Rij
Department of Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
J Vasc Surg 40:296-302. 2004The recurrence of varicose veins is a common and costly consequence of varicose vein surgery. Despite the long history and vast experience of varicose vein surgery, the exact cause of recurrence is still unknown...
- Recurrent varicose veins after surgery: a new appraisal of a common and complex problem in vascular surgeryT Kostas
Division of Vascular Surgery, University Hospital of Heraklion, Heraklion, Crete, Greece
Eur J Vasc Endovasc Surg 27:275-82. 2004..To assess the true incidence, the reflux patterns and the mechanisms responsible for recurrent varicose vein disease according to current definitions and guidelines...
- Varicose veins: newer, better treatments availableJohn R Bartholomew
Department of Cardiovascular Medicine, Section of Vascular Medicine, The Cleveland Clinic Foundation, OH, 44195, USA
Cleve Clin J Med 72:312-4, 319-21, 325-8. 2005b>Varicose veins are not only a cosmetic annoyance: they can lead to complications that result in lost time from work and lost wages...
- A prospective double-blind randomized controlled trial of radiofrequency versus laser treatment of the great saphenous vein in patients with varicose veinsIan M Nordon
St George s Vascular Institute, St James Wing, St George s Hospital, London, United Kingdom
Ann Surg 254:876-81. 2011Endovenous ablation of varicose veins using radiofrequency ablation (RFA) and endovenous laser therapy (EVLT) has reported advantages over traditional open surgical treatment...
- Proof-of-principle study of steam ablation as novel thermal therapy for saphenous varicose veinsRenate R van den Bos
Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands
J Vasc Surg 53:181-6. 2011..laser ablation have been challenging the position of traditional surgery for the treatment of saphenous varicose veins. The newest method of thermal ablation is pulsated steam, which works by heating the vein with steam at 120°C...
- Increased activation of the hypoxia-inducible factor pathway in varicose veinsChung S Lim
Academic Section of Vascular Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom
J Vasc Surg 55:1427-39. 2012..demonstrated that the average minimum oxygen tensions were significantly lower in VVs compared with non-varicose veins (NVVs)...
- The role of postoperative neovascularisation in recurrence of varicose veins: from historical background to today's evidenceM G R De Maeseneer
Department of Thoracic and Vascular Surgery, University Hospital Antwerp, Belgium
Acta Chir Belg 104:283-9. 2004Recurrence of varicose veins at the sapheno-femoral or sapheno-popliteal junction can not always be explained by technical inadequacy of the original intervention...
- [Diagnosis and treatment of varicose veins: part 2: therapeutic procedures and results]H Nüllen
Gemeinschaftspraxis für Gefässmedizin in Mönchengladbach GPG MG, Rheydter Str 276, 41065, Mönchengladbach, Deutschland
Chirurg 81:1125-37; quiz 1138. 2010This is the second of two articles on the diagnosis and treatment of varicose veins. Primary varicosis is a congenital degenerative disease of the peripheral venous system of the lower extremities...
- Endovenous ablation of the great saphenous vein may avert phlebectomy for branch varicose veinsHarold J Welch
Department of Vascular Surgery, Lahey Clinic and Tufts University School of Medicine, MA, USA
J Vasc Surg 44:601-5. 2006..ablation of the great saphenous vein (GSV) may be performed simultaneously with stab phlebectomy of branch varicose veins or as a stand-alone procedure...
- Dysregulated apoptosis in primary varicose veinsE Ducasse
Unit of Vascular Surgery, Clinic Umberto I, University La Sapienza, Rome, Italy
Eur J Vasc Endovasc Surg 29:316-23. 2005..To investigate its possible pathogenic role in primary varicose veins we studied histological changes in surgical specimens from human varicose veins...
- Unusual sudden death: two case reports of hemorrhage by rupture of varicose veinsStephanie Racette
Laboratoire de Sciences Judiciaires et de Médecine Légale, Montreal, Quebec, Canada
Am J Forensic Med Pathol 26:294-6. 2005Although varicose veins are frequent, they are rarely considered lethal. Still, rupture of a varicosity can result in significant and even fatal hemorrhage. External hemorrhage is an unusual complication of this common venous pathology...
- Treatment options for primary varicose veins--a reviewR J Beale
Vascular Surgical Unit, The General Infermary at Leeds, Great George Street, Leeds LS1 3EX, UK
Eur J Vasc Endovasc Surg 30:83-95. 2005
- Smooth muscle cell hypertrophy in varicose veins is associated with expression of estrogen receptor-betaMichiel W M Knaapen
HistoGeneX, Edegem, Belgium
J Vasc Res 42:8-12. 2005b>Varicose veins are characterized by dilated and thickened vein walls. This study examined whether the changes that occur in varicose veins are associated with smooth muscle cell (SMC) hypertrophy, cellular proliferation or apoptosis...
- Percutaneus treatment of varicose veins with bipolar radiofrequency ablationR Boon
Department of Surgery, Spaarne Hospital, Hoofddorp, The Netherlands
Eur J Radiol 75:43-7. 2010..Linear endovenous energy density (LEED) describes the amount of energy used for vein closure...
- Foam and liquid sclerotherapy for varicose veinsPhilip Coleridge Smith
London Vein Institute, London WIG 6 LF, UK
Phlebology 24:62-72. 2009..The objective of this study is to review the methods and outcome of ultrasound-guided foam sclerotherapy (UGFS) for the treatment of superficial venous incompetence...
- Varicose veins show enhanced chemokine expressionL del Rio Solá
Vascular Surgery Division, Hospital Clinico Universitario, Valladolid, Spain
Eur J Vasc Endovasc Surg 38:635-41. 2009Leucocyte infiltration in the wall of varicose veins has been reported previously...
- Recurrent varicose veins following surgical treatment: our experience with five years follow-upC Allegra
Department of Angiology, S Giovanni Hospital, Rome, Italy
Eur J Vasc Endovasc Surg 33:751-6. 2007To report the 5 year outcome of varicose veins surgery and to establish the factors determining recurrence.
- Bladder varices--rare cause of painless hematuria in idiopathic retroperitoneal fibrosisC George Koshy
Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India
Urology 73:58-9. 2009..No recurrence of the hematuria was noted on follow-up. We have described a unique presentation of hematuria due to vesical varices in a patient with idiopathic retroperitoneal fibrosis...
- Arterioportal fistula causing jejunal variceal hemorrhageLevent Filik
Turkiye Yuksek Ihtisas Hospital, Gastroenterology Clinics, Ankara, Turkey
Turk J Gastroenterol 14:266-9. 2003..Hemorrhage was controlled with medical treatment. Since he refused any surgical intervention he was discharged and advised to continue follow-up...
- A case of fatal spontaneous varicose vein rupture--an example of incorrect first aidPetr Hejna
Institute of Legal Medicine, Charles University, Prague, Czech Republic
J Forensic Sci 54:1146-8. 2009..Death was caused by a hypovolemic shock because of external hemorrhage from a varicose vein...
- Radiofrequency ablation vs conventional surgery for varicose veins - a comparison of treatment costs in a randomised trialS Subramonia
General Surgery, King s Mill Hospital, Mansfield, UK
Eur J Vasc Endovasc Surg 39:104-11. 2010To compare the costs involved (from procedure to recovery) following radiofrequency ablation and conventional surgery for lower limb varicose veins in a selected population.
- Incidence of varicose veins in FinlandL A Mäkivaara
Tampere School of Public Health, Tampere University, Finland
Vasa 33:159-63. 2004Incidence of varicose veins in the population is unknown. The study aimed at estimating the incidence of varicose veins in complete cohorts of 40-60 year-olds in a general population.
- Systematic review of treatments for varicose veinsDeanne Leopardi
Australian Safety and Efficacy Register of New Interventional Procedures Surgical, Royal Australasian College of Surgeons, Adelaide, South Australia, Australia
Ann Vasc Surg 23:264-76. 2009..Evidence suggests conservative therapy is less effective than sclerotherapy and surgery for the treatment of varicose veins. Ligation with stripping plus phlebectomy is generally regarded as the "gold standard" for treating primary ..
- Elastic fibers in saphenous varicose veinsLuis Cristovao Porto
Department of Histology and Embryology, Instituto de Biologia Roberto Alcantara Gomes, and Angiology service of the State University of Rio de Janeiro, Iguaçu University, Brazil
Angiology 53:131-40. 2002..In the media, the elastic network around smooth muscle cell bundles is disrupted and the Dem diminishes as the media becomes sclerotic...
- HMG-CoA reductase inhibitors reduce matrix metalloproteinase-9 activity in human varicose veinsS Nomura
Department of Medical Bioregulation, Yamaguchi University School of Medicine, Ube, Japan
Eur Surg Res 37:370-8. 2005Matrix metalloproteinases (MMPs) have been implicated in tissue degradation in varicose veins. The aim of this study was to investigate the effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) on the activity of ..
- Incomplete removal of great saphenous vein is the most common cause for recurrent varicose veinsDhiraj Joshi
Department of General and Vascular Surgery, Watford General Hospital, Watford, UK
Angiology 62:198-201. 2011Hie-tie and great saphenous vein (GSV) stripping decreases recurrence of varicose veins (VVs). However, varying lengths of residual-GSV are observed in patients with previous GSV stripping. This may explain high recurrence rates of VVs...
- Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairsM Y M Ng
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH
J Med Genet 42:235-9. 2005The FOXC2 gene on 16q24 is mutated in lymphoedema distichiasis (LD), in which varicose veins (VV) are a common feature...
- Three-Dimensional CT venography of varicose veins of the lower extremity: image quality and comparison with doppler sonographyWhal Lee
Department of Radiology, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul National University Medical Research Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
AJR Am J Roentgenol 191:1186-91. 2008The purpose of this study was to verify the imaging quality of CT venography in the clinical evaluation of the lower extremity superficial venous system and to correlate the CT and duplex sonographic findings about varicose veins.
- Endovascular Laser Treatment of Varicose VeinsDILIP PAITHANKAR; Fiscal Year: 2004..wavelength for photothermal coagulation and destruction of the greater saphenous vein (GSV) for treatment of varicose veins. Varicose veins are a significant medical and cosmetic problem with high incidence, especially among women...
- Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous InsufficiencyRaouf A Khalil; Fiscal Year: 2013..Chronic venous insufficiency (CVI) is a common and costly disease characterized by excessive vein dilation and varicose veins. CVI commonly occurs in the lower extremity, suggesting a role of venous pressure and vein wall stretch...
- The Incidence and Progression of Peripheral Venous DiseaseMichael H Criqui; Fiscal Year: 2010..a multi-ethnic population the presence or absence, and degree of concordance, of visible disease -normal (NL), varicose veins (W), trophic changes (TCS), and functional disease (reflux or obstruction) by Duplex ultrasound -normal, ..
- PROTEASE MODULATING WOUND DRESSINGS FOR THE TREATMENT OF VENOUS ULCERSDAVID VACHON; Fiscal Year: 2006..The major causes of venous insufficiency, potentially leading to non-healing stasis ulcers, include varicose veins, deep venous thrombosis, neoplastic obstructions, and congenital or acquired arterio-venous fistulae...
- Pycnogenol for Treatment of Arm LymphedemaPaul Hutson; Fiscal Year: 2004..Pycnogenol(r) is widely used in Europe for lymphedema of the leg and varicose veins, and is thought to act by several mechanisms including vascular permeability and vascular constriction...
- Mechanisms of Varicose Vein FormationMark D Iafrati; Fiscal Year: 2010DESCRIPTION (provided by applicant): Varicose veins are focal vessel dilitations present in up to 30% of the adult population and clearly associated with significant morbidity...
- GENES FOR VASCULAR MORPHOGENESIS: A GENETIC APPROACHQing Wang; Fiscal Year: 2003..us to understand the molecular mechanisms underlying KTS as well as other common vascular disorders such as varicose veins and venous malformations...
- SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTIONVictor Gordeuk; Fiscal Year: 2004..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..
- Howard-CNMC Sickle Cell Disease Clinical CenterVictor Gordeuk; Fiscal Year: 2008..A major feature of both sickle cell programs has always been continuity of care and participation in collaborative research. ..
- Pulmonary Hypertension and the Hypoxic Response in SCDVictor Gordeuk; Fiscal Year: 2008..Aim 3. Using micro array analysis and high throughput genotyping, examine patterns of gene expression and candidate gene polymorphisms of the HIF-mediated hypoxic response in SCD and CP patients with and without PHTN. ..
- MANAGEMENT OF PATIENTS WITH SUSPECTED PULMONARY EMBOLISHSuman Rathbun; Fiscal Year: 2005..abstract_text> ..
- ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIESVIRGINIA MILLER; Fiscal Year: 2002..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
- Individual Propensity to Venous ThrombosisJohn Heit; Fiscal Year: 2009..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..
- Integrated Photothermal NanoprobesVladimir Zharov; Fiscal Year: 2007..The results of these studies will also make it possible to formulate recommendations on the desired properties of new, clustered nanomaterials for medical applications. [unreadable] [unreadable] [unreadable]..
- MECHANISMS OF ENDOTHELIAL DYSFUNCTION IN DIABETICSJoshua Beckman; Fiscal Year: 2003..abstract_text> ..
- Photothermal Evaluation of Drug Toxicity at Cell LevelVladimir Zharov; Fiscal Year: 2004..abstract_text> ..
- BREATH HOLD 3D MRA OF THE CORONARY ARTERIESRobert Edelman; Fiscal Year: 2002..The goal is to optimize the MRA method and to determine if the use of contrast agents provides any clinical benefit. ..
- Smash Contrast-Enhanced 3D MR AngiographyRobert Edelman; Fiscal Year: 2002....
- Smash Contrast-Enhanced 3D MR AngiographyRobert Edelman; Fiscal Year: 2003....
- Gene Delivery to the Trabecular MeshworkDouglas Rhee; Fiscal Year: 2004..These studies would set the foundation for future evaluations of the function of MIF in the TM and MIF?s potential as a candidate for gene therapy for the treatment of glaucoma. ..
- Photothermal Imaging of Live CellsVladimir Zharov; Fiscal Year: 2008..The technical realization of PTI is relatively simple, requiring the combination of conventional optical phase-contrast microscopy and the already routinely used nanosecond laser. ..
- MULTICENTER RANDOMIZED TRIAL OF DSRS VERSUS TIPSJohn Henderson; Fiscal Year: 2004..The extension of this trial, will provide the most comprehensive and longest follow-up for these two shunt procedures for control of variceal bleeding. ..
- Integrated optical imaging rat of mesenteryVladimir Zharov; Fiscal Year: 2004..The technical realization of this new imaging system is relatively simple, combining transmission microscopy and laser technique already routinely in use. ..
- Neurite density in skin as a marker for neuropathic painAnne Louise Oaklander; Fiscal Year: 2005..abstract_text> ..
- Activation of clotting & cell adhesion: gas embolismDavid M Eckmann; Fiscal Year: 2010..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..
- H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESISFritz Francois; Fiscal Year: 2008..From these studies, both the microbial contribution and the host genotype contribution to adenocarcinoma risk should be able to be assessed, as well as to begin to define relevant cellular pathways. ..