peripheral vascular diseases

Summary

Summary: General or unspecified diseases of the blood vessels outside the heart. It is for diseases of the peripheral as opposed to the cardiac circulation.

Top Publications

  1. ncbi ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Sur
    Alan T Hirsch
    Circulation 113:e463-654. 2006
  2. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    J Vasc Surg 45:S5-67. 2007
  3. ncbi Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Circulation 110:738-43. 2004
  4. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  5. ncbi ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary a collaborative report from the American Association for Vascular Surgery/Society for Vas
    Alan T Hirsch
    J Am Coll Cardiol 47:1239-312. 2006
  6. ncbi Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality
    Srjdan Prodanovich
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Arch Dermatol 145:700-3. 2009
  7. ncbi Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics
    Kenichiro Sho
    Department of Ophthalmology, Kansai Medical University, Fumizono cho, Moriguchi, Osaka, Japan
    Arch Ophthalmol 121:1392-6. 2003
  8. ncbi Medical treatment of peripheral arterial disease
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth
    JAMA 295:547-53. 2006
  9. ncbi Functional decline in peripheral arterial disease: associations with the ankle brachial index and leg symptoms
    Mary Mcgrae McDermott
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    JAMA 292:453-61. 2004
  10. ncbi Atherosclerotic disease: whole-body cardiovascular imaging with MR system with 32 receiver channels and total-body surface coil technology--initial clinical results
    Michael Fenchel
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Radiology 238:280-91. 2006

Research Grants

  1. GPCR Signaling &Vascular Wall Remodeling
    Gadiparthi N Rao; Fiscal Year: 2013
  2. NFATs and Vascular Injury
    Gadiparthi N Rao; Fiscal Year: 2013
  3. Novel Regulators of Vascular Disease
    Paul W Sanders; Fiscal Year: 2013
  4. Novel Manufacturing Processes for Tissue Engineered Vascular Grafts
    Shannon L M Dahl; Fiscal Year: 2013
  5. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
  6. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
  7. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
  8. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
  9. Reducing Risk Factors in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
  10. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004

Detail Information

Publications271 found, 100 shown here

  1. ncbi ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Sur
    Alan T Hirsch
    Circulation 113:e463-654. 2006
  2. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    J Vasc Surg 45:S5-67. 2007
  3. ncbi Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Circulation 110:738-43. 2004
    ..Peripheral arterial disease (PAD) is associated with significant morbidity and mortality and is an important marker of subclinical coronary heart disease. However, estimates of PAD prevalence in the general US population have varied widely...
  4. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  5. ncbi ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary a collaborative report from the American Association for Vascular Surgery/Society for Vas
    Alan T Hirsch
    J Am Coll Cardiol 47:1239-312. 2006
  6. ncbi Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality
    Srjdan Prodanovich
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Arch Dermatol 145:700-3. 2009
    To examine the cardiovascular risk factors in patients with psoriasis and the association between psoriasis and coronary artery, cerebrovascular, and peripheral vascular diseases.
  7. ncbi Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics
    Kenichiro Sho
    Department of Ophthalmology, Kansai Medical University, Fumizono cho, Moriguchi, Osaka, Japan
    Arch Ophthalmol 121:1392-6. 2003
    ..To clarify the incidence, demographic features, and clinical characteristics of polypoidal choroidal vasculopathy (PCV) in Japanese patients...
  8. ncbi Medical treatment of peripheral arterial disease
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth
    JAMA 295:547-53. 2006
    ..The goals of treatment are to prevent future major coronary and cerebrovascular events and improve leg symptoms...
  9. ncbi Functional decline in peripheral arterial disease: associations with the ankle brachial index and leg symptoms
    Mary Mcgrae McDermott
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    JAMA 292:453-61. 2004
    ..However, relations between these clinical characteristics and objectively measured functional decline are unknown...
  10. ncbi Atherosclerotic disease: whole-body cardiovascular imaging with MR system with 32 receiver channels and total-body surface coil technology--initial clinical results
    Michael Fenchel
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Radiology 238:280-91. 2006
    ..For patients suspected of having systemic atherosclerotic disease, comprehensive risk assessment is feasible within 30 minutes...
  11. ncbi Refractory neovascular age-related macular degeneration secondary to polypoidal choroidal vasculopathy
    Minhee Cho
    New York University School of Medicine Manhattan Eye, Ear and Throat Hospital, Department of Ophthalmology, New York, New York, USA
    Am J Ophthalmol 148:70-8.e1. 2009
    ..To describe a neovascular pattern associated with treatment-refractory neovascular age-related macular degeneration (AMD)...
  12. ncbi The influence of peripheral arterial disease on outcomes: a pooled analysis of mortality in eight large randomized percutaneous coronary intervention trials
    Jacqueline Saw
    Department of Medicine, Division of Cardiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 48:1567-72. 2006
    ..We aimed to evaluate clinical outcomes among peripheral arterial disease (PAD) patients following percutaneous coronary intervention (PCI)...
  13. ncbi One-year outcomes of photodynamic therapy in age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 115:141-6. 2008
    ....
  14. ncbi Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry
    Patrice P Cacoub
    Pierre and Marie Curie University Paris 6, and AP HP, Hospital La Pitié Salpêtrière, Paris, France
    Atherosclerosis 204:e86-92. 2009
    ..To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates...
  15. ncbi Risk factors for progression of peripheral arterial disease in large and small vessels
    Victor Aboyans
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0607, USA
    Circulation 113:2623-9. 2006
    ..Using noninvasive tests, we assessed the role of traditional and novel risk factors on PAD progression. We hypothesized that the risk factors for large-vessel PAD (LV-PAD) progression might differ from small-vessel PAD (SV-PAD)...
  16. ncbi Balloon angioplasty versus implantation of nitinol stents in the superficial femoral artery
    Martin Schillinger
    Department of Angiology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria
    N Engl J Med 354:1879-88. 2006
    ..We evaluated whether primary implantation of a self-expanding nitinol (nickel-titanium) stent yielded anatomical and clinical benefits superior to those afforded by percutaneous transluminal angioplasty with optional secondary stenting...
  17. ncbi Association of ARMS2/HTRA1 variants with polypoidal choroidal vasculopathy phenotype in a Korean population
    Dong Ho Park
    Department of Ophthalmology, School of Medicine, Kyungpook National University, 50 Samduk dong 2 ga, Jung Gu, Daegu 700 721, South Korea
    Jpn J Ophthalmol 56:60-7. 2012
    ..To investigate whether ARMS2 (rs10490924)/HTRA1 (rs11200638) variants are associated with polypoidal choroidal vasculopathy (PCV) in a Korean population and with various PCV phenotypes...
  18. ncbi Background comparison of typical age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Takashi Ueta
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    Ophthalmology 116:2400-6. 2009
    ..To compare background factors of the 2 most dominant subtypes of exudative age-related macular degeneration (AMD) in the Japanese population: typical AMD and polypoidal choroidal vasculopathy (PCV)...
  19. ncbi Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy
    Norimoto Gotoh
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Jpn J Ophthalmol 54:609-14. 2010
    ..2 kb, were genotyped. Associations were tested using single-SNP and haplotype analyses...
  20. ncbi Role of photodynamic therapy in polypoidal choroidal vasculopathy
    Eriko Akaza
    Department of Ophthalmology, Surugadai Hospital of Nihon University, Kanda, Tokyo, Japan
    Jpn J Ophthalmol 51:270-7. 2007
    ..To determine the efficacy of photodynamic therapy (PDT) with verteporfin for polypoidal choroidal vasculopathy (PCV)...
  21. ncbi The ankle-brachial index in the elderly and risk of stroke, coronary disease, and death: the Framingham Study
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702 5827, USA
    Arch Intern Med 163:1939-42. 2003
    ..Limited data exist regarding the relation between a low ABI and stroke. We sought to examine the relation between a low ABI and stroke, coronary heart disease, and death in the elderly...
  22. ncbi Utility and barriers to performance of the ankle-brachial index in primary care practice
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Vasc Med 9:253-60. 2004
    ..The ABI is a simple peripheral arterial disease detection tool that can be successfully applied in primary care office practices...
  23. ncbi Prevalence and prediction of previously unrecognized peripheral arterial disease in patients with coronary artery disease: the Peripheral Arterial Disease in Interventional Patients Study
    Issam D Moussa
    Division of Cardiology, New York Presbyterian Hospital Weill Cornell Medical Center, Weill Medical College of Cornell University, New York, New York, USA
    Catheter Cardiovasc Interv 73:719-24. 2009
    ..Peripheral arterial disease (PAD) is under diagnosed in primary care practices, yet the extent of unrecognized PAD in patients with coronary artery disease (CAD) is unknown...
  24. pmc Atherosclerotic risk factors are less intensively treated in patients with peripheral arterial disease than in patients with coronary artery disease
    M M McDermott
    Department of Medicine, Northwestern University Medical School Chicago, IL 60611, USA
    J Gen Intern Med 12:209-15. 1997
    ..8, p = .01). CONCLUSIONS: Atherosclerotic risk factors are less intensively treated among PAD patients than CAD patients. A number of possible explanations could account for these disparities in therapeutic intensity...
  25. ncbi Prevalence of the metabolic syndrome in patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm
    Petra M Gorter
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Atherosclerosis 173:363-9. 2004
    ....
  26. ncbi Stem cell and progenitor cell therapy in peripheral artery disease. A critical appraisal
    Holger Lawall
    Angiology Diabetology, SRH Klinikum Karlsbad Langensteinbach, Karlsbad, Germany
    Thromb Haemost 103:696-709. 2010
    ..Preliminary evidence has established its safety, feasibility and effectiveness on several important endpoints. Several large endpoints studies are underway to further consolidate this evidence...
  27. ncbi Pathological features of surgically excised polypoidal choroidal vasculopathy membranes
    Sachiko Kuroiwa
    Shinshu University School of Medicine, Matsumoto, Japan
    Clin Experiment Ophthalmol 32:297-302. 2004
    ..This study indicates that large choroidal arterioles and venules can be found in excised specimens from patients with polypoidal choroidal vasculopathy and arteriosclerosis is an important pathological feature...
  28. ncbi Peripheral arterial stiffness and endothelial dysfunction in idiopathic and scleroderma associated pulmonary arterial hypertension
    Nir Peled
    Pulmonary Institute, Rabin Medical Center, Petah Tiqwa, Israel
    J Rheumatol 36:970-5. 2009
    ..However, the systemic vascular involvement is not fully understood. Our study focused on the systemic arterial stiffness and endothelial involvement in idiopathic and scleroderma associated PAH...
  29. ncbi Ethnic differences in peripheral arterial disease in the NHLBI Genetic Epidemiology Network of Arteriopathy (GENOA) study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA
    Vasc Med 8:237-42. 2003
    ..Identifying additional 'novel' risk factors that account for the ethnic differences in PAD is an important next step towards understanding why such differences exist and developing more effective strategies to reduce the burden of PAD...
  30. ncbi Ankle-brachial index and extent of atherothrombosis in 8891 patients with or at risk of vascular disease: results of the international AGATHA study
    F Gerald R Fowkes
    Department of Public Health Sciences, Wolfson Unit for the Prevention of Peripheral Vascular Diseases, University of Edinburgh, Edinburgh EH8 9AG, UK
    Eur Heart J 27:1861-7. 2006
    ..The principal hypotheses were that (1) in diseased patients, a low ABI was related to the number and site of vascular beds affected and (2) in at-risk patients without disease, a low ABI was related to the number of risk factors present...
  31. ncbi High prevalence of peripheral arterial disease in persons with renal insufficiency: results from the National Health and Nutrition Examination Survey 1999-2000
    ANN M O'HARE
    Staff Physician, VA Medical Center San Francisco, Box 111J Nephrology, 4150 Clement St, San Francisco, CA 94121, USA
    Circulation 109:320-3. 2004
    ..Although renal insufficiency is a recognized risk factor for coronary artery disease, little is known about the epidemiology of lower-extremity peripheral arterial disease (PAD) in persons with renal insufficiency...
  32. ncbi Gaps in public knowledge of peripheral arterial disease: the first national PAD public awareness survey
    Alan T Hirsch
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Ste 300, 1300 S 2nd St, Minneapolis, MN 55454, USA
    Circulation 116:2086-94. 2007
    ..Nevertheless, public knowledge of PAD as a morbid and mortal disease has not been previously assessed...
  33. ncbi Leg symptoms in peripheral arterial disease: associated clinical characteristics and functional impairment
    M M McDermott
    Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    JAMA 286:1599-606. 2001
    ..Persons with lower-extremity peripheral arterial disease (PAD) are often asymptomatic or have leg symptoms other than intermittent claudication (IC)...
  34. ncbi Risk factors for asymptomatic abdominal aortic aneurysm: systematic review and meta-analysis of population-based screening studies
    Jacques Cornuz
    Department of Medicine and Institute of Social and Preventive Medicine, University Hospital, Lausanne, Switzerland
    Eur J Public Health 14:343-9. 2004
    ..There is uncertainty regarding the indicators which could be used to identify groups at high risk. This issue has been addressed in a systematic review of population-based screening studies...
  35. ncbi Prior polyvascular disease: risk factor for adverse ischaemic outcomes in acute coronary syndromes
    Deepak L Bhatt
    VA Boston Healthcare System and Brigham and Women s Hospital, Boston, MA, USA
    Eur Heart J 30:1195-202. 2009
    ....
  36. ncbi Inter-society consensus for the management of peripheral arterial disease
    L Norgren
    Int Angiol 26:81-157. 2007
  37. ncbi Peripheral arterial disease: morbidity and mortality implications
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0995, USA
    Circulation 114:688-99. 2006
  38. ncbi Diabetes and atherosclerosis: epidemiology, pathophysiology, and management
    Joshua A Beckman
    Leducq Center for Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    JAMA 287:2570-81. 2002
    ..Complications of atherosclerosis cause most morbidity and mortality in patients with diabetes mellitus. Despite the frequency and severity of disease, proven medical therapy remains incompletely understood and underused...
  39. ncbi Mitochondrial defects and oxidative damage in patients with peripheral arterial disease
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 41:262-9. 2006
    ..Peripheral arterial disease is associated with abnormal mitochondrial function and evidence of significant oxidative stress...
  40. ncbi Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, VA Medical Center San Francisco, University of California, San Francisco, CA, USA
    Circulation 113:388-93. 2006
    ..A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population...
  41. ncbi Nitinol stent implantation in long superficial femoral artery lesions: 12-month results of the DURABILITY I study
    Marc Bosiers
    Department of Vascular Surgery, AZ St Blasius, Dendermonde, Belgium
    J Endovasc Ther 16:261-9. 2009
    ..To evaluate the long-term efficacy and integrity of the PROTEGE EverFlex stent in superficial femoral artery (SFA) lesions in symptomatic patients with peripheral artery disease (PAD)...
  42. ncbi Critical issues in peripheral arterial disease detection and management: a call to action
    Jill J F Belch
    Department of Medicine, Ninewells Hospitals and Medical School, Scotland
    Arch Intern Med 163:884-92. 2003
  43. ncbi Polypoidal choroidal vasculopathy and treatments
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Curr Opin Ophthalmol 19:208-12. 2008
    ..This review assesses the current knowledge of the clinical characteristics of polypoidal choroidal vasculopathy and treatments...
  44. ncbi Osteoprotegerin plasma concentrations correlate with severity of peripheral artery disease
    Sophie Ziegler
    Division of Angiology, Department of Internal Medicine II, Medical University Vienna, Vienna, Austria
    Atherosclerosis 182:175-80. 2005
    ..In the present study on patients with peripheral artery disease (PAD), we correlated plasma OPG concentrations with severity of disease and the presence of cardiovascular risk factors...
  45. ncbi Frequency of new coronary events in older persons with peripheral arterial disease and serum low-density lipoprotein cholesterol > or = 125 mg/dl treated with statins versus no lipid-lowering drug
    Wilbert S Aronow
    Cardiology Division, Department of Medicine, Westchester Medical Center New York Medical College, Valhalla, New York, USA
    Am J Cardiol 90:789-91. 2002
  46. ncbi Augmentation index as a measure of peripheral vascular disease state
    Wilmer W Nichols
    Department of Medicine Cardiology, University of Florida College of Medicine, Gainesville, 32610, USA
    Curr Opin Cardiol 17:543-51. 2002
    ..This change in amplitude and timing of the reflected wave causes a generalized change in central arterial systolic and pulse pressure that is not detected by cuff pressure measurements in the brachial artery...
  47. ncbi Prognosis and management of patients with acute coronary syndrome and polyvascular disease
    Ignacio Ferreira-Gonzalez
    Area del Cor, Servicio de Cardiologia, Hospital Vall d Hebron, Barcelona, Espana
    Rev Esp Cardiol 62:1012-21. 2009
    ..To assess prognosis and patterns of care in patients with acute coronary syndrome and peripheral arterial disease (PAD), cerebrovascular disease or both (i.e., polyvascular disease) in everyday clinical practice...
  48. ncbi Impact of polyvascular disease on baseline characteristics, management and mortality in acute myocardial infarction. The Alliance project
    Anouk Meizels
    INSERM U 698 Recherche Clinique en Athérothrombose, Service de cardiologie, Centre Hospitalier Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, université Paris VII Denis Diderot, 75877 Paris Cedex 18, France
    Arch Cardiovasc Dis 103:207-14. 2010
    ..A substantial number of patients with acute myocardial infarction (AMI) have polyvascular disease (PolyVD), defined as cerebrovascular disease (CVD), peripheral arterial disease (PAD) or both...
  49. ncbi Peripheral magnetic resonance angiography with continuous table movement in combination with high spatial and temporal resolution time-resolved MRA With a total single dose (0.1 mmol/kg) of gadobutrol at 3.0 T
    Matthias Voth
    University Medical Center Mannheim, Institute of Clinical Radiology and Nuclear Medicine, University of Heidelberg, Mannheim, Germany
    Invest Radiol 44:627-33. 2009
    ..0 T with a single dose (0.1 mmol/kg) of gadobutrol in total...
  50. ncbi Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease
    C Iribarren
    Division of Research, Kaiser Permanente Medical Care Program, 3505 Broadway, Oakland, CA 94611
    JAMA 283:2810-5. 2000
    ..However, the incremental predictive value of vascular calcification, beyond traditional coronary risk factors, is not clearly established...
  51. ncbi Sustained benefit at 2 years of primary femoropopliteal stenting compared with balloon angioplasty with optional stenting
    Martin Schillinger
    Department of Angiology, Medical University, Vienna, Austria
    Circulation 115:2745-9. 2007
    ..We now report 2-year data on restenosis and clinical outcomes of these patients...
  52. ncbi Aggregation of features of the metabolic syndrome is associated with increased prevalence of chronic complications in Type 2 diabetes
    L A Costa
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Diabet Med 21:252-5. 2004
    ..To investigate the association of features of the metabolic syndrome with the prevalence of chronic complications...
  53. ncbi Peripheral arterial disease: identification and implications
    Emile R Mohler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Intern Med 163:2306-14. 2003
    ..Once diagnosed, risk factor modification, symptomatic relief, and secondary prevention strategies with antiplatelet agents form the core of medical management of PAD...
  54. ncbi The United States preventive services task force recommendation statement on screening for peripheral arterial disease: more harm than benefit?
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 114:861-6. 2006
    ..We encourage the USPSTF to reevaluate the extant data, add vascular specialty expertise to its review group, and reconsider its recommendation...
  55. ncbi The impact of peripheral arterial disease on health-related quality of life in the Peripheral Arterial Disease Awareness, Risk, and Treatment: New Resources for Survival (PARTNERS) Program
    Judith G Regensteiner
    Department of Medicine, University of Colorado School of Medicine, Denver, CO 80262, USA
    Vasc Med 13:15-24. 2008
    ....
  56. ncbi Reproducibility and reliability of the ankle-brachial index as assessed by vascular experts, family physicians and nurses
    Tim Holland-Letz
    Department of Medical Informatics, Biometry and Epidemiology, Ruhr University Bochum, Germany
    Vasc Med 12:105-12. 2007
    ..Additional studies will be required to confirm our observations in patients with PAD of various severities...
  57. ncbi Automated oscillometric determination of the ankle-brachial index provides accuracy necessary for office practice
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 47:35-8. 2006
    ..Our findings show automated oscillometry to be a reliable and easier method of ABI measurement, lowering the barrier to incorporation of this diagnostic test into clinical practice...
  58. ncbi Exercise training for claudication
    Kerry J Stewart
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 347:1941-51. 2002
  59. ncbi Impact of cardioselective beta-blockers on mortality in patients with chronic obstructive pulmonary disease and atherosclerosis
    Yvette R B M van Gestel
    Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 178:695-700. 2008
    ..There is a general reluctance to prescribe beta-blockers in patients with chronic obstructive pulmonary disease (COPD) because they may worsen symptoms...
  60. ncbi Peripheral arterial disease - high prevalence in rural black South Africans
    Ashis Kumar
    Department of Family Medicine, Mthatha General Hospital, Eastern Cape, South Africa
    S Afr Med J 97:285-8. 2007
    ..The Eastern Cape is a rural area and patients attending the hospital are mostly Xhosa-speakers...
  61. ncbi Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy
    Kelvin Y Lee
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 49:2613-9. 2008
    ..Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these associations occur in Chinese patients with PCV...
  62. ncbi Neovascularization induced by autologous bone marrow cell implantation in peripheral arterial disease
    Kensuke Esato
    Division of Cardiovascular Surgery, Department of Bioregulation, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, Japan 755 8505
    Cell Transplant 11:747-52. 2002
    ..No relative toxicity was observed in any of the patients. BMCI might be a feasible treatment for selected patients with chronic PAD...
  63. ncbi Sex differences in peripheral arterial disease: leg symptoms and physical functioning
    Mary Mcgrae McDermott
    Department of Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
    J Am Geriatr Soc 51:222-8. 2003
    ..To compare lower extremity functioning and leg symptoms between women and men with peripheral arterial disease (PAD)...
  64. ncbi LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-related macular degeneration in a Japanese population
    Naoshi Kondo
    Department of Organs Therapeutics, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Ophthalmol 144:608-12. 2007
    ....
  65. ncbi Relationship between temporal-spatial gait parameters, gait kinematics, walking performance, exercise capacity, and physical activity level in peripheral arterial disease
    Robert G Crowther
    Institute of Sport and Exercise Science, James Cook University, Townsville Hospital, Queensland, Australia
    J Vasc Surg 45:1172-8. 2007
    ....
  66. ncbi The ankle brachial index is associated with leg function and physical activity: the Walking and Leg Circulation Study
    Mary Mcgrae McDermott
    Feinberg School of Medicine at Northwestern University and Catholic Health Partners, Chicago, Illinois, USA
    Ann Intern Med 136:873-83. 2002
    ..The ankle brachial index (ABI) is a noninvasive, reliable measure of lower-extremity ischemia. However, the relationship between ABI and lower-extremity function has not been well studied...
  67. ncbi Limitation of the resting ankle-brachial index in symptomatic patients with peripheral arterial disease
    Russell Stein
    Zena and Michael A Wiener Cardiovascular Institute, Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai Medical Center, New York, NY 10029, USA
    Vasc Med 11:29-33. 2006
    ..Furthermore, when the ABI is normal at rest in patients with symptoms of intermittent claudication, exercise testing is recommended to enhance the sensitivity for detection of PAD...
  68. ncbi Validation of a new method of detecting peripheral artery disease by determination of ankle-brachial index using an automatic blood pressure device
    Alain Benchimol
    Service Medical Inter Entreprise, Saintes, France
    Angiology 55:127-34. 2004
    ..The use of a simple, automatic blood pressure device to determine ABI appears feasible, easy, and precise. It would provide a practical tool for physicians not trained in Doppler to detect PAD...
  69. ncbi Impact of prior peripheral arterial disease and stroke on outcomes of acute coronary syndromes and effect of evidence-based therapies (from the Global Registry of Acute Coronary Events)
    Debabrata Mukherjee
    Gill Heart Institute and the University of Kentucky, Lexington, Kentucky, USA
    Am J Cardiol 100:1-6. 2007
    ..In conclusion, outcomes after ACS are worse in patients with PAD or stroke, with the highest risk in patients with the 2 conditions and the use of evidence-based therapies are associated with improved outcomes in all ACS subgroups...
  70. ncbi Peripheral arterial disease versus other localizations of vascular disease: the ATTEST study
    Jacques Blacher
    Hotel Dieu Hospital, Universite Paris Descartes, Faculte de Medecine, AP HP, Paris, France
    J Vasc Surg 44:314-8. 2006
    ..Despite the increased cardiovascular morbidity and mortality risk of patients with peripheral arterial disease, previous worldwide studies have documented undertreatment of cardiovascular risk factors in such patients...
  71. ncbi Impaired elastic properties of the ascending aorta in newborns before and early after successful coarctation repair: proof of a systemic vascular disease of the prestenotic arteries?
    Manfred Vogt
    Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Munchen, Technische Universitat, Munich, Germany
    Circulation 111:3269-73. 2005
    ..To find out whether these abnormalities are primarily present or develop later, we studied 17 newborns before and early after surgical repair...
  72. ncbi Prevalence of peripheral arterial disease and risk factors in persons aged 60 and older: data from the National Health and Nutrition Examination Survey 1999-2004
    Yechiam Ostchega
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA
    J Am Geriatr Soc 55:583-9. 2007
    ..Peripheral arterial disease (PAD) is associated with significant cardiovascular morbidity and mortality. The study objectives were to examine the prevalence of PAD and associated risk factors...
  73. ncbi Diabetes guidelines: easier to preach than to practise?
    Wendy Bryant
    Diabetes Centre, St Vincent s Hospital, Sydney, NSW, Australia
    Med J Aust 185:305-9. 2006
    ..To review the management of glycaemia, blood pressure and serum lipids in a hospital outpatient diabetes clinic, the director of which co-authored the current national diabetes management guidelines...
  74. ncbi Heparin-bonded Dacron or polytetrafluorethylene for femoropopliteal bypass: five-year results of a prospective randomized multicenter clinical trial
    Carol Devine
    Department of Surgery, Wythenshawe Hospital, Manchester M23 9LT, England
    J Vasc Surg 40:924-31. 2004
    ..Despite the range of potential prosthetics, polytetrafluoroethylne (PTFE) clearly predominates in current femoropopliteal practice. We compared heparin-bonded Dacron (HBD) with PTFE in a randomized multicenter clinical trial...
  75. ncbi Natural history of limbs with arterial insufficiency and chronic ulceration treated without revascularization
    William A Marston
    Division of Vascular Surgery, Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7212, USA
    J Vasc Surg 44:108-114. 2006
    ..In this report, we describe the outcome of limbs with stable chronic leg ulcers and arterial insufficiency that were treated with wound-healing techniques in patients who were not candidates for revascularization...
  76. ncbi The role of exercise training in peripheral arterial disease
    Richard V Milani
    Department of Cardiovascular Disease, Ochsner Clinic Foundation, New Orleans, LA, USA
    Vasc Med 12:351-8. 2007
    ..This paper will review the benefits of supervised exercise training in patients with PAD...
  77. ncbi Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part II
    Thomas F Luscher
    Cardiology, Cardiovascular Center, University Hospital and Cardiovascular Research, Institute of Physiology, University Zurich, Switzerland
    Circulation 108:1655-61. 2003
  78. ncbi Cardioprotective medication is associated with improved survival in patients with peripheral arterial disease
    Harm H H Feringa
    Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 47:1182-7. 2006
    ..We sought to investigate the effect of cardiac medication on long-term mortality in patients with peripheral arterial disease (PAD)...
  79. ncbi Ankle-brachial index, a screening for peripheral obstructive arterial disease, and migraine - a controlled study
    Mauro Eduardo Jurno
    Hospital Regional FHEMIG Neurology, Barbacena, Brazil
    Headache 50:626-30. 2010
    ..The ankle-brachial index (ABI) is largely used as a surrogate of peripheral obstructive arterial disorders (POAD). Accordingly, in this study we contrasted the ABI in individuals with migraine and in controls...
  80. ncbi Hemorrhagic complications after photodynamic therapy for polypoidal choroidal vasculopathy
    Yasuhiko Hirami
    Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Retina 27:335-41. 2007
    ..To evaluate the clinical features and risk factors of hemorrhagic complications in eyes with polypoidal choroidal vasculopathy (PCV) after photodynamic therapy (PDT)...
  81. ncbi The rationale for using HMG-CoA reductase inhibitors ('statins') in peripheral arterial disease
    G Erez
    Center for Research, Prevention and Treatment of Atherosclerosis, Department of Medicine B, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Eur J Vasc Endovasc Surg 33:192-201. 2007
    ..Further, larger randomized controlled studies with statins are needed to evaluate the efficacy of statin therapy in patients with stable peripheral arterial disease and in those undergoing vascular or endovascular surgery...
  82. ncbi Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115 1204, USA
    Circulation 97:425-8. 1998
    ..Whether increased levels of CRP are also associated with the development of symptomatic peripheral arterial disease (PAD) is unknown...
  83. ncbi Excess 1-year cardiovascular risk in elderly primary care patients with a low ankle-brachial index (ABI) and high homocysteine level
    Stefan Lange
    Department of Medical Informatics, Biometry and Epidemiology, University of Bochum, Universitatsstr 150, D 44801 Bochum, Germany
    Atherosclerosis 178:351-7. 2005
    ..6 [2.1, 20.9]. Patients with a low ABI have a substantially increased risk of (short-term) all-cause mortality. The combination of a low ABI and high HC level is particularly useful for identifying patients at excess risk...
  84. ncbi Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience
    Sanjay Rajagopalan
    Section of Vascular Medicine, 473 W 12th Ave, Division of Cardiovascular Medicine, Ohio State University, Columbus, OH 43210 1252, USA
    Circulation 115:1234-43. 2007
    ....
  85. ncbi Peripheral arterial disease--epidemiological aspects
    M H Criqui
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla 92093, USA
    Vasc Med 6:3-7. 2001
    ..Thus, accurate diagnosis of PAD could provide an early indication of the need for intervention and help prevent future morbidity and mortality...
  86. ncbi Polypoidal choroidal vasculopathy in Caucasians
    B A Lafaut
    Department of Ophthalmology, Ghent University Hospital, Belgium
    Graefes Arch Clin Exp Ophthalmol 238:752-9. 2000
    ....
  87. ncbi Statin use and leg functioning in patients with and without lower-extremity peripheral arterial disease
    Mary Mcgrae McDermott
    Feinberg School of Medicine at Northwestern University, Chicago, Ill, USA
    Circulation 107:757-61. 2003
    ..We determined whether statin use (versus nonuse) is associated with superior lower-extremity functioning independently of cholesterol levels and other confounders in patients with and without peripheral arterial disease...
  88. ncbi Risk factors for premature peripheral vascular disease: results for the National Health and Nutritional Survey, 1999-2002
    John S Lane
    Department of Surgery, University of California, San Francisco, CA, USA
    J Vasc Surg 44:319-24; discussion 324-5. 2006
    ..We hypothesized that different risk factors predict the development of PVD in patients <60 years than in patients > or =60 years...
  89. ncbi Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization
    Jian Ping Tong
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, PRC
    Am J Ophthalmol 141:456-62. 2006
    ....
  90. ncbi Polypoidal choroidal vasculopathy in tilted disk syndrome and high myopia with staphyloma
    Martine Mauget-Faysse
    Rabelais Ophthalmologic Center, Lyon, France
    Am J Ophthalmol 142:970-5. 2006
    ..To describe polypoidal choroidal vasculopathy as a complication of tilted disk syndrome and high myopia with staphyloma...
  91. ncbi The intra- and interobserver variability of ankle-arm blood pressure index according to its mode of calculation
    Victor Aboyans
    Department of Cardiovascular Surgery and Vascular Medicine, Dupuytren University Hospital 2, Martin Luther King Avenue, Limoges F 87042, France
    J Clin Epidemiol 56:215-20. 2003
    ....
  92. ncbi Prior peripheral arterial disease and cerebrovascular disease are independent predictors of adverse outcome in patients with acute coronary syndromes: are we doing enough? Results from the Orbofiban in Patients with Unstable Coronary Syndromes-Thrombolysi
    Gad Cotter
    Cardiology Institutes of Assaf Harofeh Medical Center, Zerifin, Israel
    Am Heart J 145:622-7. 2003
    ....
  93. ncbi Does arsenic exposure increase the risk of development of peripheral vascular diseases in humans?
    Chun Yuh Yang
    Institute of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung City, Taiwan
    J Toxicol Environ Health A 69:1797-804. 2006
    ..Based on the reversibility criterion, the association between arsenic exposure and PVD-attributed mortality is likely to be causal...
  94. ncbi Statin therapy improves cardiovascular outcome of patients with peripheral artery disease
    Martin Schillinger
    Division of Angiology, Department of Internal Medicine II, Vienna General Hospital, Medical School, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur Heart J 25:742-8. 2004
    ..We sought to examine the interrelationship between statin use, inflammation, and outcome of high-risk patients with advanced atherosclerosis...
  95. ncbi Management of peripheral arterial disease
    Daniela C Gey
    U S Army Medical Department Activity, Heidelberg, Germany
    Am Fam Physician 69:525-32. 2004
    ..Effective drug therapies for peripheral arterial disease include aspirin (with or without dipyridamole), clopidogrel, cilostazol, and pentoxifylline...
  96. ncbi Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease
    Curt Diehm
    Department of Internal Medicine Vascular Medicine, SRH Klinikum Karlsbad Langensteinbach, Affiliated Teaching Hospital, University of Heidelberg, Guttmannstr 1, D 76307 Karlsbad, Germany
    Circulation 120:2053-61. 2009
    ..Our aim was to assess the mortality and vascular morbidity risk of elderly individuals with asymptomatic versus symptomatic peripheral artery disease (PAD) in the primary care setting...
  97. ncbi Comparison of outcomes of patients with symptomatic peripheral artery disease with and without atrial fibrillation (the West Birmingham Atrial Fibrillation Project)
    Dwayne S G Conway
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, United Kingdom
    Am J Cardiol 93:1422-5, A10. 2004
    ..Patients with symptomatic peripheral artery disease and atrial fibrillation should be regarded as "high risk" and managed with optimal medical therapy, including appropriate thromboprophylaxis and close follow-up...
  98. pmc Inorganic nitrite and chronic tissue ischaemia: a novel therapeutic modality for peripheral vascular diseases
    Christopher B Pattillo
    Department of Pathology and Cardiology, LSU Health Sciences Center Shreveport, 1501 Kings Hwy, Shreveport, LA 71130, USA
    Cardiovasc Res 89:533-41. 2011
    ..This review highlights the emergence of nitrite anion as a selective NO prodrug for ischaemic tissue disorders and discusses the potential therapeutic utility of this agent for peripheral vascular disease...
  99. ncbi Long-term results of peripheral arterial disease rehabilitation
    Julie R Menard
    Department of Physical Education and Exercise Science, University of Rhode Island, Kingston, RI, USA
    J Vasc Surg 39:1186-92. 2004
    ..This study examined functional status, walking ability, and quality of life in patients several months after completion of a 12-week PADRx...
  100. ncbi Cost per day of patency: understanding the impact of patency and reintervention in a sustainable model of healthcare
    Michael C Stoner
    Department of Cardiovascular Sciences, East Carolina University, Greenville, NC 27858 4354, USA
    J Vasc Surg 48:1489-96. 2008
    ..Herein we describe an amortized cost model that accounts for procedural costs, durability, and re-intervention costs...
  101. ncbi Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Neurol Sci 287:45-51. 2009
    ..9 were significant predisposing factors for stroke. Patients with CVD and co-existing atherothrombotic diseases had a high risk of recurrent events, including events arising in other vascular beds than originally diagnosed...

Research Grants63

  1. GPCR Signaling &Vascular Wall Remodeling
    Gadiparthi N Rao; Fiscal Year: 2013
    ..RELEVANCE: Vascular smooth muscle cell (VSMC) migration and proliferation play an important role in peripheral vascular diseases such as atherosclerosis and restenosis following angioplasty or vein grafting...
  2. NFATs and Vascular Injury
    Gadiparthi N Rao; Fiscal Year: 2013
    ..RELEVANCE: Vascular smooth muscle cell (VSMC) migration and proliferation play an important role in peripheral vascular diseases such as atherosclerosis and restenosis following angioplasty or vein grafting...
  3. Novel Regulators of Vascular Disease
    Paul W Sanders; Fiscal Year: 2013
    ..diseases such as systolic hypertension, cerebrovascular, cardiovascular, renovascular, and peripheral vascular diseases - all represent a significant burden affecting the Veteran population...
  4. Novel Manufacturing Processes for Tissue Engineered Vascular Grafts
    Shannon L M Dahl; Fiscal Year: 2013
    ..including cardiovascular complications of diabetes and obesity, ... and peripheral vascular diseases." Humaycte has developed a novel vascular graft that has shown excellent function in large animal ..
  5. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
  6. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
    ..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
  7. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  8. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
  9. Reducing Risk Factors in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ....
  10. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  11. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
  12. Coupled Gene Delivery and Protein Transduction for the Reduction of Atheroscleros
    JOHN DAISS; Fiscal Year: 2009
    ..Approximately 10% of the population at risk for developing cardiovascular and peripheral vascular diseases is unable to take therapeutic doses of current lipid lowering therapies due to undesirable side effects ..
  13. Atypical regulation of vascular tone by protein kinase C
    Thomas Robertson; Fiscal Year: 2005
    The functional heterogeneity of the vasculature contributes to the etiology of pulmonary and peripheral vascular diseases. Protein kinase C (PKC) is a pivotal regulator of vascular tone and is divided into classical PKCs (cPKC), novel ..
  14. EXERCISE FOR ELDERLY PERIPHERAL REVASCULARIZED PATIENTS
    Andrew Gardner; Fiscal Year: 2004
    ....
  15. Home-based vs. Supervised Exercise for Claudicants
    Andrew W Gardner; Fiscal Year: 2010
    ....
  16. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
    ..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
  17. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  18. Biomarkers of Peripheral Arterial Disease
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  19. Thrombus resolution is CXC chemokine dependent
    Peter Henke; Fiscal Year: 2006
    ..abstract_text> ..
  20. Vein wall remodeling after DVT is matrix metalloproteinase dependent
    Peter Henke; Fiscal Year: 2009
    ..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
  21. Proteomic Markers of Arteriosclerosis
    Iftikhar Kullo; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  22. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
    ..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
  23. Multifactor Risk Reduction for Optimal Management in Peripheral Arterial Disease
    Roberta K Oka; Fiscal Year: 2010
    ..This study will examine the effect of a system that assists providers to reduce a patient's CVD risk factors and explores the biological reasons that this system may be effective in improving health. ..
  24. MECHANISMS OF ENDOTHELIAL DYSFUNCTION IN DIABETICS
    Joshua Beckman; Fiscal Year: 2003
    ..abstract_text> ..
  25. Defining the Clinical Significance of HbA1c Prior to the Onset of Diabetes
    Elizabeth Selvin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  26. Determinants of Shear Stress-Mediated Arterial Remodeling
    Joseph Vita; Fiscal Year: 2009
    ....
  27. The Incidence and Progression of Peripheral Venous Disease
    Michael H Criqui; Fiscal Year: 2010
    ..This application builds on the seminal findings in our prevalence study, and since no such incidence data exist, is original and innovative. ..
  28. Osteoprotegerin and osteopontin in aortic aneurysm
    Jonathan Golledge; Fiscal Year: 2009
    ..Understanding the role of these calcium-controlling proteins in artery weakness and how drug therapy can interfere in these effects is an important step in the development of new treatment for aortic aneurysm. ..
  29. Effect of Antioxidants on Inflammatory Markers and FMVD
    Christopher Gardner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. Mercury, Arsenic, and Carotid Atherosclerosis
    Eliseo Guallar; Fiscal Year: 2007
    ..Relevance: Confirmation of the role of mercury or arsenic on atherogenesis could impact current environmental and dietary public health recommendations. [unreadable] [unreadable]..
  31. Clinical Utility of Endothelial Function in PAD
    Joseph Vita; Fiscal Year: 2007
    ..This work will provide novel information about the pathogenesis and management of PAD. ..
  32. Benefits & Risks of Popular Weight Loss Diets
    Christopher Gardner; Fiscal Year: 2003
    ..The data generated from this preliminary/feasibility study will be used to strengthen the proposal and design of a future full-scale study. ..
  33. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..The information obtained in this study will be relevant to millions of children in the US and abroad who are chronically exposed to lead, cadmium, and arsenic in the environment. ..
  34. Peripheral Arterial Disease and Leg Muscle Metabolism
    LOIS KILLEWICH; Fiscal Year: 2005
    ..It is my ultimate hope that the combined interventions of bypass surgery and nutritional supplementation with amino acids can be used to improve overall functional status of these elderly Americans. ..
  35. CT EVALUATION OF DIABETIC TIBIAL ARTERY CALCIFICATION
    RAUL GUZMAN; Fiscal Year: 2006
    ..Our ultimate goal is to prevent the marco-vascular complications of diabetes, and to decrease the incidence of lower extremity amputation that causes disability in our patients. ..
  36. Ethnic differences in peripheral arterial disease
    Michael Criqui; Fiscal Year: 2004
    ..This is the first attempt to see if these newer risk markers can explain ethnic differences in PAD. Thus, this application is highly innovative and addresses original hypotheses. ..
  37. Mechanisms By Which Endothelium Cells Sense Changes in Hemodynamics
    Bauer Sumpio; Fiscal Year: 2007
    ..4. Assess egr-1 and sp1 binding in MT1-MMP and PDGF-B promoters under mechanical stress 5.Assess the functional relevance of egr-1 in a low flow carotid model using an egr-1 knock-out mouse. ..
  38. Bone Morphogenetic Proteins in Arterial Remodeling
    RAUL GUZMAN; Fiscal Year: 2006
    ..It is expected that during this award period, Dr. Guzman will progress toward his goal of becoming an independent scientific investigator...
  39. Comparing Effects of 3 Sources of Garlic on Serum Lipids
    Christopher Gardner; Fiscal Year: 2005
    ..The comprehensive approach taken in this study will provide important evidence for both the public and for health professionals as to whether fresh garlic or garlic supplements have beneficial effects on serum lipids. ..
  40. GENETIC ENGINEERING OF A FAILURE RESISTANT VEIN GRAFT
    Michael Conte; Fiscal Year: 2003
    ..The long term objective is to develop a safe, efficient, and effective protocol for intraoperative gene therapy that will engineer vein bypass grafts that are resistant to occlusion. ..
  41. Heavy Metals, Obesity and Cardiovascular Risk
    Eliseo Guallar; Fiscal Year: 2005
    ....
  42. A central aortic pulse wave velocity measurement device
    Gary Mitchell; Fiscal Year: 2005
    ..This innovative technology will enable accurate diagnosis and risk stratification in a primary care setting and will facilitate further research aimed at evaluating interventions that may reduce conduit vessel stiffness. ..
  43. ALA & EPA/DHA (w-3) Effects On Inflammatory Markers in Insulin Resistant Adults
    Christopher Gardner; Fiscal Year: 2007
    ..The adults with the metabolic syndrome selected for this study are those that are at increased risk of heart disease, and those most likely to be benefit from the different therapies tested. [unreadable] [unreadable] [unreadable]..
  44. Aortic Calcium: epidemiology and progression
    Michael Criqui; Fiscal Year: 2006
    ..abstract_text> ..
  45. Lipoproteins, HIV, and Antiretroviral Therapy in SMART
    Daniel Duprez; Fiscal Year: 2008
    ..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  46. Atheroclerosis in rheumatoid arthritis cohort
    INMACULADA DEL RINCON; Fiscal Year: 2005
    ..This would ultimately lengthen life expectancy and improve the quality of life of people with inflammatory diseases. ..
  47. Association of Thrombophilia and Inflammation with Post-Thrombotic Syndrome
    Mary Cushman; Fiscal Year: 2008
    ..Resultant disability is estimated at 2 million lost workdays/year and medical costs as $300 million yearly. Findings here can form the basis for development of new therapies to treat, and moreover prevent,PTS. ..
  48. Role of Cell Cycle Proteins in Apoptosis
    CHRISTINE LOGAR; Fiscal Year: 2006
    ..Our ultimate goal is to show novel roles for specific cell cycle proteins in glomerular disease so that specific therapeutic strategies can be developed. [unreadable] [unreadable]..
  49. ADMA: An endogenous inhibitor of ESC differentiation and EC regeneration
    John Cooke; Fiscal Year: 2007
    ..This proposal will provide fundamental insights regarding the use of ESC- derived EC for endothelial regeneration, with specific attention to therapeutic angiogenesis, and its regulation by NOS. [unreadable] [unreadable] [unreadable]..
  50. STATINS AND NON-CARDIAC ENDPOINTS
    Beatrice Golomb; Fiscal Year: 2003
    ....
  51. REGIONAL BETA ADRENERGIC DURING LV REMODELING
    Christopher Kramer; Fiscal Year: 2002
    ..Effects of beta-blockade on regional cell morphometry, collagen content, and blood flow will be assessed using isolated myocytes, quantitative histopathology, and fluorescent microspheres, respectively. ..
  52. RISK FACTORS FOR DIABETIC RETINOPATHY IN BLACK AMERICANS
    Monique Roy; Fiscal Year: 2003
    ..abstract_text> ..
  53. Lifecourse Socioeconomic Status and Kidney Disease
    Suma Vupputuri; Fiscal Year: 2005
    ..Valuable new, information on the effects of SES across life course on chronic kidney disease and on putative intervening mechanisms that are amenable to preventive and therapeutic approaches will be ascertained. ..
  54. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2007
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..
  55. Air Pollution Exposure/Atherosclerosis:Vascular Mechanism
    Sanjay Rajagopalan; Fiscal Year: 2007
    ..This study is expected to provide a firm linkage between CAPS exposure and atherosclerosis progression and will provide a pathophysiologic basis for the adverse cardiovascular effects of CAPS. ..
  56. Clinical Research Using Non-Fourier 3D Cardiac MRI
    Frank Rybicki; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  57. HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTS
    SHARI WALDSTEIN; Fiscal Year: 2008
    ..abstract_text> ..
  58. Self-Management in African Americans with Diabetes and Hypertension
    Elizabeth Lynch; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  59. Genetic Determinants of PAD
    John Cooke; Fiscal Year: 2007
    ..Sinai and Stanford University which has extensive expertise in cell and vascular biological studies, integrative physiology, human genomic and genetic studies, epidemiology and clinical trials in PAD. ..
  60. Comprehensive Magnetic Resonance in PAD
    Christopher Kramer; Fiscal Year: 2008
    ..Improving the health outcomes and quality of life in patients with PAD is a major goal of this proposal. ..
  61. Cooperative Lifestyle Intervention Program
    WALTER REJESKI; Fiscal Year: 2009
    ..Analyses will also be conducted to determine whether changes in the primary outcome are mediated by changes in constructs from social cognitive theory. ..
  62. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2002
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..