Genomes and Genes
Summary: A drop in blood pressure upon standing or after standing motionless in a static position.
Publications275 found, 100 shown here
- EFNS guidelines on the diagnosis and management of orthostatic hypotensionH Lahrmann
Neurological Department and L Boltzmann Institute for Neurooncology, Kaiser Franz Josef Hospital, Vienna, Austria
Eur J Neurol 13:930-6. 2006..Fludrocortisone is a valuable starter drug. Second line drugs include sympathomimetics, such as midodrine, ephedrine, or dihydroxyphenylserine. Supine hypertension has to be considered...
- Clinical practice. Neurogenic orthostatic hypotensionRoy Freeman
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
N Engl J Med 358:615-24. 2008
- Management of neurogenic orthostatic hypotension: an updatePhillip A Low
Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
Lancet Neurol 7:451-8. 2008b>Orthostatic hypotension (OH) is common in elderly people and in patients with disorders such as diabetes and Parkinson's disease. Grading of the severity of OH and its effect on the patient's quality of life are important...
- Cardiac denervation occurs independent of orthostatic hypotension and impaired heart rate variability in Parkinson's diseaseC A Haensch
Department of Neurology and Clinical Neurophysiology, HELIOS Klinikum Wuppertal, University of Witten Herdecke, Heusnerstrasse 40, D 42283 Wuppertal, Germany
Parkinsonism Relat Disord 15:134-7. 2009..Here we analyzed the correlation between cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake, orthostatic hypotension and heart rate variability in treated patients with PD...
- Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's diseaseL M Allcock
Parkinson s Disease Research Unit, Department of Neurology, Sunderland Royal Hospital and Institute for Ageing and Health, University of Newcastle, Sunderland, UK
J Neurol Neurosurg Psychiatry 75:1470-1. 2004The frequency of orthostatic hypotension (OH) in cohorts of patients recruited through hospital Parkinson's disease (PD) clinics ranges from 16% to 58%. However, hospital based cohorts may be subject to ascertainment bias...
- A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotensionFang Luo
Hypertension Division, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, China
Hypertension 54:796-801. 2009..has an impact on the antihypertensive response to hydrochlorothiazide, and is associated with orthostatic hypotension, we performed a case-control study of hypertension (n=1686), a 4-week clinical trial (n=542), and a case-..
- Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart ProgramK H Masaki
Honolulu Heart Program, Kuakini Medical Center, Honolulu, Hawaii, USA
Circulation 98:2290-5. 1998Population-based data are unavailable concerning the predictive value of orthostatic hypotension on mortality in ambulatory elderly patients, particularly minority groups.
- Norepinephrine precursor therapy in neurogenic orthostatic hypotensionHoracio Kaufmann
Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
Circulation 108:724-8. 2003In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture.
- Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study GroupP A Low
Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
JAMA 277:1046-51. 1997..a 10-mg dose of midodrine 3 times per day in improving blood pressure (BP) and ameliorating symptoms of orthostatic hypotension in patients with neurogenic orthostatic hypotension...
- Association between supine hypertension and orthostatic hypotension in autonomic failureDavid S Goldstein
the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Hypertension 42:136-42. 2003..This study explored whether supine hypertension in this setting is associated with orthostatic hypotension (OH), and if so, what mechanisms might underlie this association...
- Orthostatic hypotension and the incidence of coronary heart disease: the Atherosclerosis Risk in Communities studyK M Rose
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, USA
Am J Hypertens 13:571-8. 2000We examined the association between orthostatic hypotension (OH) at baseline examination (1987-1989) and the incidence of coronary heart disease (CHD) over an average of 6 years, among 12,433 black and white middle-aged men and women ..
- L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failureC J Mathias
Neurovascular Medicine Unit, Division of Neuroscience and Psychological Medicine, Imperial College of Science, Technology, and Medicine at St Mary s, London, UK
Clin Auton Res 11:235-42. 2001..tolerability of increasing doses of L-threo-dihydroxyphenylserine (L-threo-DOPS) in treating symptomatic orthostatic hypotension associated with multiple system atrophy (MSA) and pure autonomic failure (PAF)...
- Orthostatic hypotension, balance and falls in Parkinson's diseaseMaarit Matinolli
Department of Neurology, University of Oulu, Oulu, Finland
Mov Disord 24:745-51. 2009b>Orthostatic hypotension (OH) is a common feature in Parkinson's disease (PD). As the control of balance and gait is already affected by PD per se, OH may further predispose patients to falls and accidents...
- Population-based study on the prevalence and correlates of orthostatic hypotension/hypertension and orthostatic dizzinessJin Shang Wu
Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
Hypertens Res 31:897-904. 2008There are no epidemiological studies of orthostatic hypotension (OH)/hypertension (OHT) and orthostatic dizziness (OD) in adults across all age groups...
- Prevalence of orthostatic hypotensionPhillip A Low
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Clin Auton Res 18:8-13. 2008b>Orthostatic hypotension (OH) is defined as a fall in blood pressure of at least 20 mmHg systolic or 10 mmHg diastolic when standing or during head-up tilt testing...
- Symptoms associated with orthostatic hypotension in pure autonomic failure and multiple system atrophyC J Mathias
Neurovascular Medicine Unit, Division of Neurosience and Psychological Medicine, Imperial College School of Medicine at St Mary s Hospital, Praed Street, London W2 INY, UK
J Neurol 246:893-8. 1999The symptoms caused by or relating to orthostatic hypotension (over 20 mmHg systolic blood pressure) were evaluated using a questionnaire in 72 patients with primary chronic autonomic failure, 32 of whom had pure autonomic failure (PAF, ..
- Orthostatic hypotension: framework of the syndromeJochanan E Naschitz
Department of Internal Medicine A, Bnai Zion Medical Center, Haifa, Israel
Postgrad Med J 83:568-74. 2007According to the 1996 consensus definition, orthostatic hypotension (OH) is diagnosed when a fall in systolic blood pressure of at least 20 mm Hg and/or diastolic blood pressure of at least 10 mm Hg within 3 min of standing is recorded...
- Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotensionYehonatan Sharabi
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Mov Disord 23:1725-32. 2008..About 40% have neurogenic orthostatic hypotension (NOH), and among PD+NOH patients virtually all have evidence of cardiac sympathetic denervation; however, ..
- Hypotension unawareness in profound orthostatic hypotensionSteven D Arbogast
Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
Am J Med 122:574-80. 2009Clinicians depend on history given by the patients when considering the diagnosis of orthostatic hypotension.
- Are current recommendations to diagnose orthostatic hypotension in Parkinson's disease satisfactory?Jenny Jamnadas-Khoda
School of Health and Related Research, Sheffield University, Sheffield, United Kingdom
Mov Disord 24:1747-51. 2009..using a questionnaire to verify the reliability of orthostatic symptoms in warning the presence of orthostatic hypotension (OH)...
- Measuring orthostatic hypotension with the Finometer device: is a blood pressure drop of one heartbeat clinically relevant?Nathalie van der Velde
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood Press Monit 12:167-71. 2007The role of orthostatic hypotension in falls in older people is generally accepted...
- Water drinking in the management of orthostatic intolerance due to orthostatic hypotension, vasovagal syncope and the postural tachycardia syndromeC J Mathias
Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
Eur J Neurol 11:613-9. 2004..has been shown to raise blood pressure in normal subjects and in patients with autonomic failure who have orthostatic hypotension. However, in normal young subjects, ingestion of approximately 500 ml has no pressor effect; but in older ..
- Acute orthostatic hypotension when starting dopamine agonists in Parkinson's diseaseK Kujawa
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
Arch Neurol 57:1461-3. 2000To study the frequency and severity of acute orthostatic hypotension (OH) in patients with Parkinson's disease who are starting dopamine agonist therapy.
- High prevalence of orthostatic hypotension in mild dementiaHogne Sonnesyn
Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
Dement Geriatr Cogn Disord 28:307-13. 2009b>Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia.
- Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measuresChristine Schrezenmaier
Autonomic Disorders Center, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Mayo Clin Proc 80:330-4. 2005To compare measured autonomic deficits (composite autonomic severity score [CASS]) with a brief self-report scale we developed to measure severity of symptoms of orthostatic hypotension.
- Orthostatic hypotension and long-term incidence of atrial fibrillation: the Malmö Preventive ProjectA Fedorowski
Center for Emergency Medicine, Skane University Hospital, Malmo, Sweden
J Intern Med 268:383-9. 2010b>Orthostatic hypotension (OH), a common manifestation of autonomic dysfunction, has been identified as an independent risk factor for all-cause mortality and incident cardiovascular disease...
- Orthostatic hypotension and cognitive function: the Atherosclerosis Risk in Communities StudyKathryn M Rose
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
Neuroepidemiology 34:1-7. 2010To examine the association between orthostatic hypotension (OH) and cognitive function in middle-aged adults.
- Cognitive functioning in orthostatic hypotension due to pure autonomic failureHannah C Heims
Dept of Neuropsychology, Box 37, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
Clin Auton Res 16:113-20. 2006..However, a failure in integrated bodily arousal responses during cognitive behaviours may also contribute to some of the observed deficits...
- Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's diseaseKerrie L Schoffer
Department of Neurology, Royal Brisbane and Women s Hospital, Brisbane, and Department of Medicine, University of Queensland, Australia
Mov Disord 22:1543-9. 2007There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease...
- Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and managementJ M Senard
Laboratory of Medical and Clinical Pharmacology, INSERM U317, Faculty of Medicine, Paul Sabatier University, Toulouse, France
Drugs Aging 18:495-505. 2001b>Orthostatic hypotension is common in elderly patients, and is now considered to be an important prognostic factor for cognitive decline and mortality...
- Orthostatic hypotension as an early finding in Parkinson's diseaseDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10 Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892, USA
Clin Auton Res 16:46-54. 2006Patients with Parkinson's disease (PD) commonly have clinically significant orthostatic hypotension (OH)...
- The pathophysiology and diagnosis of orthostatic hypotensionDavid Robertson
Autonomic Dysfunction Center, Depts of Medicine and Pharmacology, Vanderbilt University, AA 3228 Medical Center North, 1161 21st Avenue South, Nashville, TN 37323 2195, USA
Clin Auton Res 18:2-7. 2008b>Orthostatic Hypotension (OH) is a common manifestation of blood pressure dysregulation. OH takes a heavy toll on quality of life. It has many potential etiologies, and many effects of aging can increase susceptibility to OH...
- Initial orthostatic hypotension: review of a forgotten conditionWouter Wieling
Department of Internal Medicine, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
Clin Sci (Lond) 112:157-65. 2007..An exaggerated transient BP (blood pressure) fall upon standing is the underlying cause. IOH (initial orthostatic hypotension) is defined as a transient BP decrease within 15 s after standing, >40 mmHg SBP (systolic BP) and/or &..
- Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: autonomic symptom and demographic comparisonLiesl M Allcock
Institute of Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
Mov Disord 21:1851-5. 2006The objective of this study was to characterize the phenotypic associations of orthostatic hypotension (OH) in Parkinson's disease (PD)...
- Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam studyGermaine C Verwoert
Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
J Am Geriatr Soc 56:1816-20. 2008To determine the prognostic role of orthostatic hypotension for cardiovascular disease (CVD) and all-cause mortality in elderly people.
- Insular pathology in Parkinson's disease patients with orthostatic hypotensionSpiridon Papapetropoulos
Department of Neurology, University of Miami, Miller School of Medicine, Room 4004, 1501 NW 9th Avenue, Miami, FL 33136, USA
Parkinsonism Relat Disord 13:308-11. 2007b>Orthostatic hypotension (OH) in Parkinson's disease (PD) patients may be a significant source of morbidity and discomfort...
- Autoregulatory cerebral vasodilation occurs during orthostatic hypotension in patients with primary autonomic failureD R Horowitz
Department of Neurology, The Mount Sinai School of Medicine, New York, New York 10029, USA
Clin Auton Res 11:363-7. 2001....
- Orthostatic hypotension in de novo Parkinson diseaseUbaldo Bonuccelli
Department of Neuroscience, Section of Neurology, Movement Disorders Unit, University of Pisa, Pisa, Italy
Arch Neurol 60:1400-4. 2003It is accepted that orthostatic hypotension is a clinical marker for the diagnosis of multiple system atrophy, but conflicting data indicate that it may also be present in Parkinson disease (PD).
- Erythropoietin, anemia, and orthostatic hypotension: the evidence mountsSunil V Rao
Clin Auton Res 12:141-3. 2002
- Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failureAtul Pathak
Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Toulouse, France
Mov Disord 20:1213-9. 2005We investigated the effects of high-external-temperature exposure on neurogenic orthostatic hypotension (OH)...
- A clinical, physiology and pharmacology evaluation of orthostatic hypotension in the elderlyManish Sahni
Malcolm Randall VA Medical Center, GRECC, 1601 SW Archer Road, Gainesville, Florida 32608, USA
Int Urol Nephrol 37:669-74. 2005b>Orthostatic hypotension is very common in the elderly. It increases morbidity and is an independant predictor of all cause mortality...
- Delayed orthostatic hypotension: a frequent cause of orthostatic intoleranceChristopher H Gibbons
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Neurology 67:28-32. 2006To investigate the prevalence, symptoms, and neurophysiologic features of delayed orthostatic hypotension (OH).
- Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromesYehonatan Sharabi
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Clin Neuropharmacol 29:97-105. 2006Neurogenic orthostatic hypotension (OH) characterizes pure autonomic failure (PAF), multiple system atrophy (MSA), and Parkinson disease (PD) with autonomic failure...
- The treatment of orthostatic hypotension with dihydroxyphenylserineR Freeman
Division of Neurology, New England Deaconess Hospital, Boston, MA 02215
Clin Neuropharmacol 14:296-304. 1991Neurogenic orthostatic hypotension is an incapacitating symptom of central and peripheral autonomic nervous system degeneration...
- A study of orthostatic hypotension in late-life depressionJonathan Richardson
Institute for Ageing and Health, Newcastle University, England, UK
Am J Geriatr Psychiatry 17:996-9. 2009Studies examining vascular risk factors in depression report conflicting evidence but have not assessed orthostatic hypotension, a recently recognized risk factor for white matter hyperintensities.
- Orthostatic hypotension in elderly persons during passive standing: a comparison with young personsT Kawaguchi
College of Nursing Art and Science Hyogo, Akashi, Japan
J Gerontol A Biol Sci Med Sci 56:M273-80. 2001The present study was aimed at clarifying the mechanism of orthostatic hypotension (OH) that occurs in elderly persons and at investigating assisting methods to prevent OH by evaluating changes in autonomic nervous system (ANS) activity ..
- Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotensionRichard Imrich
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Parkinsonism Relat Disord 15:122-7. 2009Diseases characterized by neurogenic orthostatic hypotension (NOH), such as Parkinson disease (PD) and pure autonomic failure (PAF), are associated with cardiac sympathetic denervation, as reflected by low myocardial concentrations of 6-[..
- Urinary dysfunction and orthostatic hypotension in multiple system atrophy: which is the more common and earlier manifestation?R Sakakibara
Uro Neurology Group, Department of Neurology, Chiba University, Japan
J Neurol Neurosurg Psychiatry 68:65-9. 2000Urinary dysfunction and orthostatic hypotension are the prominent autonomic features in multiple system atrophy (MSA)...
- L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension: the European experienceChristopher J Mathias
Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, Praed Street, London, W2 1NY, UK
Clin Auton Res 18:25-9. 2008Neurogenic orthostatic hypotension is a cardinal feature of generalised autonomic failure and commonly is the presenting sign in patients with primary autonomic failure...
- Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiencyI Biaggioni
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
Lancet 2:1170-2. 1987..was given by mouth in a single-blind, placebo-controlled trial to two patients with orthostatic hypotension due to dopamine-beta-hydroxylase deficiency, in the hope of providing noradrenaline by endogenous ..
- Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulationD Robertson
Department of Pharmacology, Vanderbilt University, Nashville, Tenn 37232 2195
Hypertension 18:1-8. 1991..and hypotension, but survivors sometimes cope relatively well until late childhood when overwhelming orthostatic hypotension profoundly limits their activities. The hypotension may be so severe that clonic seizures supervene...
- Current pharmacologic treatment for orthostatic hypotensionRoy Freeman
Dept of Neurology Harvard Medical School, Center for Autonomic and Peripheral Nerve Disorders Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
Clin Auton Res 18:14-8. 2008b>Orthostatic hypotension is treated effectively with the combined use of non-pharmacological and pharmacological interventions...
- Cognition and hopelessness in association with subsyndromal orthostatic hypotensionJadwiga Czajkowska
Department of Medicine, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
J Gerontol A Biol Sci Med Sci 65:873-9. 2010..The lack of effective orthostatic BP regulation is a symptom for various problems, including fatigue, depression, anxiety, and reduced attention...
- Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotensionDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, U S A
Clin Sci (Lond) 104:649-54. 2003In multiple system atrophy (MSA) and pure autonomic failure (PAF), orthostatic hypotension (OH) results from deficient noradrenaline release from sympathetic nerves during standing...
- Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failureCyndya Shibao
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA
Hypertension 56:847-51. 2010b>Orthostatic hypotension affects patients with autonomic failure producing considerable disability because of presyncopal symptoms...
- Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotensionW Singer
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Neurol Neurosurg Psychiatry 74:1294-8. 2003Pharmacological treatment of orthostatic hypotension is often limited because of troublesome supine hypertension.
- Postural blood pressure changes and orthostatic hypotension in the elderly patient: impact of antihypertensive medicationsIhab Hajjar
Division of Geriatrics, Department of Internal Medicine, Palmetto Health Richland and University of South Carolina, Columbia, South Carolina 29203, USA
Drugs Aging 22:55-68. 2005..This predisposes elderly patients to significant changes in blood pressure upon standing and orthostatic hypotension (OH). The prevalence of OH varies according to the population being studied...
- L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US experienceHoracio Kaufmann
Dysautonomia Research Laboratory, New York University School of Medicine, 530 First Avenue, New York, NY 10016, USA
Clin Auton Res 18:19-24. 2008Neurogenic orthostatic hypotension results from failure to release norepinephrine, the neurotransmitter of sympathetic postganglionic neurons, appropriately upon standing...
- Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension: independence from levodopa treatmentDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Hypertension 46:1333-9. 2005Patients with Parkinson disease often have orthostatic hypotension. Neurocirculatory abnormalities underlying orthostatic hypotension might reflect levodopa treatment...
- Arterial stiffness as the candidate underlying mechanism for postural blood pressure changes and orthostatic hypotension in older adults: the Rotterdam StudyFrancesco U S Mattace-Raso
Section of Geriatric Medicine, Department of Internal Medicine bDepartment of Epidemiology and Biostatistics, The Netherlands
J Hypertens 24:339-44. 2006To investigate whether arterial stiffening, one of the characteristics of the aging vascular system, is associated with orthostatic hypotension.
- Preventing and treating orthostatic hypotension: As easy as A, B, CJuan J Figueroa
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Cleve Clin J Med 77:298-306. 2010b>Orthostatic hypotension is a chronic, debilitating illness that is difficult to treat...
- Selegiline in the treatment of Parkinson's disease: its impact on orthostatic hypotensionK F Bhattacharya
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
Parkinsonism Relat Disord 9:221-4. 2003..with levodopa/carbidopa in patients with Parkinson's disease, is associated with more pronounced orthostatic hypotension than treatment with levodopa/carbidopa alone...
- Neurogenic orthostatic hypotension: chasing "the fall"D Gupta
Department of Neurology, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum, Kerala, India
Postgrad Med J 84:6-14. 2008b>Orthostatic hypotension (OH) is a frequently encountered problem affecting nearly 30% of the population aged more than 60 years...
- Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotensionI F Hussain
Uro-Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 71:371-4. 2001..Two were already known to have orthostatic hypotension and were receiving treatment with ephedrine and midodrine but the third had asymptomatic hypotension...
- Sitting and standing blood pressure measurements are not accurate for the diagnosis of orthostatic hypotensionJ Cooke
Clinical Age Assessment Unit, Mid Western Regional Hospital, Dooradoyle, Limerick, Ireland
QJM 102:335-9. 2009b>Orthostatic hypotension (OH) is associated with troublesome symptoms and increased mortality. It is treatable and deserving of accurate diagnosis. This can be time consuming...
- Effect of physical countermaneuvers on orthostatic hypotension in familial dysautonomiaMarcin Tutaj
Department of Neurology, Jagiellonian University, Botaniczna 3, 31503, Krakow, Poland
J Neurol 253:65-72. 2006Familial dysautonomia (FD) patients frequently experience debilitating orthostatic hypotension. Since physical countermaneuvers can increase blood pressure (BP) in other groups of patients with orthostatic hypotension, we evaluated the ..
- Orthostatic hypotension following spinal cord injury: impact on the use of standing apparatusRamesh Chelvarajah
Spinal Research Centre, Royal National Orthopaedic Hospital, Stanmore, UK
NeuroRehabilitation 24:237-42. 2009Upright posture confers numerous medical and social benefits to a spinal cord injured (SCI) patient. Doing so is limited by symptoms of orthostatic hypotension. This is a common secondary impairment among tetraplegic sufferers.
- Effects of atrial tachypacing on symptoms and blood pressure in severe orthostatic hypotensionRitsuko Kohno
Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Pacing Clin Electrophysiol 30:S203-6. 2007The treatment of severe orthostatic hypotension (OH) is currently unsatisfactory and usually includes various pharmaceuticals to expand the blood volume and promote peripheral vasoconstriction...
- Pharmacology of orthostatic hypotension in Parkinson's disease: from pathophysiology to managementAtul Pathak
Laboratoire de Pharmacologie Medicale et Clinique, INSERM U586, 37 Allees Jules Guesde, 31073 Toulouse Cedex, France
Expert Rev Cardiovasc Ther 2:393-403. 2004b>Orthostatic hypotension is highly prevalent in the elderly, and affects up to 20% of patients with Parkinson's disease...
- The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trialR Freeman
Department of Neurology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
Neurology 53:2151-7. 1999To study the therapeutic effect and mechanism of action of 3,4-DL-threodihydroxyphenylserine (DL-DOPS) in neurogenic orthostatic hypotension.
- Incidence and outcome of orthostatic hypotension in stroke patients undergoing rehabilitationKeng He Kong
Tan Tock Seng Hospital Rehabilitation Centre, Ang Mo Kio Community Hospital, Singapore
Arch Phys Med Rehabil 84:559-62. 2003To document the incidence and outcome of orthostatic hypotension in stroke patients undergoing rehabilitation and to determine clinical variables associated with it.
- Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotensionYasuharu Tabara
Department of Geriatric Medicine, Ehime University School of Medicine, Shigenobu cho, Onsen gun, Ehime, Japan
J Hypertens 20:651-6. 2002The genetic background of orthostatic hypotension, an important risk factor for future cardiovascular morbidity and mortality, was investigated.
- Early detection of orthostatic hypotension by quantitative sudomotor axon reflex test (QSART) in type 2 diabetic patientsHiroshi Itoh
Second Department of Medicine, Asahikawa Medical College, Asahikawa
Intern Med 42:560-4. 2003b>Orthostatic hypotension is caused by autonomic nerve dysfunction, mainly by severe sympathetic nerve dysfunction in diabetic patients. Diabetes affects the peripheral nerves in a length-dependent manner...
- The association between orthostatic hypotension and medication use in the British Women's Heart and Health StudyShahrul Kamaruzzaman
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
Age Ageing 39:51-6. 2010to determine the prevalence of orthostatic hypotension (OH) and associations with medication use in community-dwelling older women.
- Drug treatment of orthostatic hypotension and vasovagal syncopeWilliam H Frishman
Department of Medicine, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
Heart Dis 5:49-64. 2003b>Orthostatic hypotension is a common problem, estimated to occur in 5 out of every 1000 individuals and in as many as 7% to 17% of patients in an acute care setting...
- [Prevalence of orthostatic hypotension in elderly hypertensive patients in primary care]L Vara González
Centro de Salud La Marina y Gerencia de Atención Primaria Médico de Familia Centro de Salud La Marina Santander Cantabria
Aten Primaria 28:151-7. 2001To find the prevalence of orthostatic hypotension (OH) and associated factors in elderly hypertensive patients in a primary care setting.
- Orthostatic hypotension predicts vascular death in older diabetic patientsHeikki Luukinen
Department of Public Health Science and General Practice, University of Oulu, Unit of General Practice, Oulu University Hospital, PB 5000, FIN 90014, Oulu, Finland
Diabetes Res Clin Pract 67:163-6. 2005Diastolic orthostatic hypotension measured 1 min after standing up (OH-D1), and systolic OH measured 3 min after standing up (OH-S3) increase vascular mortality risk among older adults...
- Orthostatic hypotension in a case with multiple sclerosisR Sakakibara
Department of Neurology, Chiba University School of Medicine, Japan
Clin Auton Res 7:163-5. 1997..Head-up tilt testing confirmed orthostatic hypotension with relative preservation of the heart rate increase...
- Orthostatic hypotension in the healthy elderlyT Atli
Ankara University School of Medicine, Department of Geriatric Medicine, 06110 Cebeci, Ankara, Turkey
Arch Gerontol Geriatr 43:313-7. 2006b>Orthostatic hypotension (OH) is a common problem in elderly people causing several complications such as falls and fractures...
- Orthostatic hypotension-related hospitalizations in the United StatesCyndya Shibao
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37212, USA
Am J Med 120:975-80. 2007b>Orthostatic hypotension has been commonly described in elderly persons and is associated with an increased risk of falls, syncope, and cerebrovascular events...
- Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotensionSatish R Raj
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
Hypertension 48:329-34. 2006b>Orthostatic hypotension (OH) can cause syncope that is difficult to treat. We have found that 473 mL (16 oz) of water can increase systolic blood pressure (SBP) by > 30 mm Hg in many OH patients (the gastropressor response)...
- What is the minimum duration of head-up tilt necessary to detect orthostatic hypotension?Jade A Gehrking
Dept of Neurology, Mayo Clinic, Rochester MN 55905, USA
Clin Auton Res 15:71-5. 2005There is uncertainty as to the minimum duration of head-up tilt (HUT) needed to detect orthostatic hypotension (OH). The orthostatic duration has variably been recommended to be 1, 2, 3, and 5 minutes...
- Characteristics of 100 consecutive patients presenting with orthostatic hypotensionA Ahsan Ejaz
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
Mayo Clin Proc 79:890-4. 2004To elucidate the demographic and clinical characteristics of a consecutive series of patients who presented for evaluation of orthostatic hypotension.
- 24-hour blood pressure monitoring in the evaluation of supine hypertension and orthostatic hypotensionA Ahsan Ejaz
Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32608, USA
J Clin Hypertens (Greenwich) 9:952-5. 2007The presence of orthostatic hypotension has been shown to be a significant, independent predictor of all-cause mortality...
- Cerebral blood flow response and its association with symptoms during orthostatic hypotensionCaroline A Rickards
U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
Aviat Space Environ Med 78:653-8. 2007The preservation of cerebral blood flow with orthostatic hypotension (e.g., following prolonged bed rest or microgravity exposure) is vital for the attenuation of symptoms and the maintenance of consciousness...
- Association between supine cerebral perfusion and symptomatic orthostatic hypotensionMatthias J P van Osch
Department of Radiology, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Neuroimage 27:789-94. 2005..investigate whether the supine resting perfusion of brain tissue in symptomatic patients suffering from orthostatic hypotension (OH) is changed compared to control subjects and whether an association exists between the resting ..
- Initial orthostatic hypotension at high altitudeKate N Thomas
University of Otago, Dunedin, New Zealand
High Alt Med Biol 11:163-7. 2010..min(-1), p = 0.01). Reduced MCAv at 3 min was comparable at sea level and altitude (both -16%). These data indicate that initial cardiovascular and cerebrovascular responses to standing are unaltered when partially acclimatized to HA...
- Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) StudyKathryn M Rose
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Circulation 114:630-6. 2006An association between orthostatic hypotension (OH) and mortality has been reported, but studies are limited to older adults or high-risk populations.
- DBH gene variants that cause low plasma dopamine beta hydroxylase with or without a severe orthostatic syndromeJ Deinum
J Med Genet 41:e38. 2004
- Prognosis of diastolic and systolic orthostatic hypotension in older personsH Luukinen
Department of Public Health Science and General Practice, University of Oulu, Oulu University Hospital, Finland
Arch Intern Med 159:273-80. 1999b>Orthostatic hypotension (OH) predicts mortality in hypertensive persons with diabetes mellitus, but no increase in mortality has been found among random samples of home-dwelling persons with OH...
- Orthostatic hypotensionJohn G Bradley
Department of Family and Community Medicine, Southern Illinois University School of Medicine, Decatur, Illinois 62526, USA
Am Fam Physician 68:2393-8. 2003b>Orthostatic hypotension is a physical finding defined by the American Autonomic Society and the American Academy of Neurology as a systolic blood pressure decrease of at least 20 mm Hg or a diastolic blood pressure decrease of at least ..
- Impairment of cerebral autoregulation in diabetic patients with cardiovascular autonomic neuropathy and orthostatic hypotensionB N Mankovsky
Institute of Endocrinology and Metabolism, Kiev, Ukraine
Diabet Med 20:119-26. 2003..However, the contribution of cardiovascular diabetic autonomic neuropathy and orthostatic hypotension to the pathogenesis of such disturbances is not known...
- Lower limb and abdominal compression bandages prevent progressive orthostatic hypotension in elderly persons: a randomized single-blind controlled studyCristian Podoleanu
Cardiologie Clinica Medicala 4, Spitalul Clinic de Urgenta, University Hospital, Targu Mures, Romania
J Am Coll Cardiol 48:1425-32. 2006..This study sought to assess the efficacy of compression bandage of legs and abdomen in preventing hypotension and symptoms...
- Orthostatic hypotension due to autonomic disorders in the hypertension clinicGeorge A Mansoor
Section of Hypertension and Vascular Diseases, University of Connecticut Health Center, Farmington, Connecticut, USA
Am J Hypertens 19:319-26. 2006Hypertension specialists are consulted regarding orthostatic hypotension (OH) or the combination of OH with supine hypertension. These clinical presentations are often associated with a variety of underlying autonomic disorders...
- Treatment of post-dialytic orthostatic hypotension with an inflatable abdominal band in hemodialysis patientsN Yamamoto
First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
Kidney Int 70:1793-800. 2006..abdominal compression with an inflatable abdominal band, a device we developed, improved post-dialytic orthostatic hypotension (OH) in hemodialysis (HD) patients...
- Pathophysiology, diagnosis, and treatment of orthostatic hypotension and vasovagal syncopeMarvin S Medow
Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
Cardiol Rev 16:4-20. 2008b>Orthostatic hypotension (OH) occurs in 0.5% of individuals and as many as 7-17% of patients in acute care settings...
- Plasma volume restoration with salt tablets and water after bed rest prevents orthostatic hypotension and changes in supine hemodynamic and endocrine variablesWendy W Waters
Human Adaptation and Countermeasures Office, Wyle Laboratories, Inc, Houston, Texas, USA
Am J Physiol Heart Circ Physiol 288:H839-47. 2005..bed rest would result in an absence of hemodynamic and endocrine changes and a reduced incidence of orthostatic hypotension. In 10 men, we measured changes from pre-bed-rest to post-bed-rest in venous and arterial pressures; ..
- Orthostatic hypotension as cause of syncope in patients older than 65 years admitted to emergency departments for transient loss of consciousnessChiara Mussi
Department of Geriatrics, University of Modena and Reggio Emilia, Italy
J Gerontol A Biol Sci Med Sci 64:801-6. 2009Syncope due to orthostatic hypotension (OH) refers to loss of consciousness caused by hypotension induced by the upright position; it is an important risk factor for fall-related physical injuries, especially in the elderly adults...
- Postural changes in blood pressure and the prevalence of orthostatic hypotension among home-dwelling elderly aged 75 years or olderP Hiitola
Department of Social Pharmacy, University of Kuopio, Kuopio, Finland
J Hum Hypertens 23:33-9. 2009..investigates the postural changes in blood pressure (BP) and heart rate and assesses the prevalence of orthostatic hypotension (OH) and its associations with the medicines used by an elderly population...
- Orthostatic hypotension in the elderly: diagnosis and treatmentVishal Gupta
Beth Israel Deaconess Medical Center, Hebrew SeniorLife, and Harvard Medical School, Boston, Mass 02131, USA
Am J Med 120:841-7. 2007b>Orthostatic hypotension is a common problem among elderly patients, associated with significant morbidity and mortality...
- Orthostatic hypotension in genetically related hypertensive and normotensive individualsArtur Fedorowski
Department of Medicine, Malmo University Hospital, Malmo, Sweden
J Hypertens 27:976-82. 2009Prevalence and determinants of orthostatic hypotension remain largely unexplored in younger individuals without significant burden of chronic diseases.
- Respiratory motor control and blood pressure regulation after spinal cord injuryALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013..pooling in the lower body during upright posture leads to a further decrease in blood pressure known as orthostatic hypotension. These conditions severely impact the overall health of SCI individuals, delay their participation in ..
- Central Endocannabinoid System Dysfunction and HypertensionJeanne L Seagard; Fiscal Year: 2013..of the baroreflex is underscored by the consequences of impaired baroreflex function - volatile BP, orthostatic hypotension, and occasionally malignant vagotonia...
- The Prevalence of Blood Pressure Abnormalities among Veterans with SCIJill Wecht; Fiscal Year: 2009..during the blood pressure assessments because several smaller studies report an increased prevalence of orthostatic hypotension among individuals with tetraplegia (2, 5, 11)...
- Intrathecal therapy for autonomic dysreflexiaPaul C Dolber; Fiscal Year: 2013..by visceral distension in rats four weeks after T4 spinal cord transection, as well as their effect on orthostatic hypotension. Specific aim 1 does so for acute intrathecal delivery of both nonselective and selective agonists to the ..
- Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular AgingFarzaneh A Sorond; Fiscal Year: 2010..linked to hypoxic-ischemic injury, such as cerebral microvascular disease, autonomic failure with orthostatic hypotension, stroke, dementia and congestive heart failure...
- Neuropeptide Regulation Vasopressin/Oxytocin SecretionCELIA SLADEK; Fiscal Year: 2006..Inadequate or inappropriate VP secretion contributes to pathologies such as orthostatic hypotension and congestive heart failure...
- Pathogenesis and Diagnosis of Multiple System Atrophy (P01)Phillip A Low; Fiscal Year: 2013..additionally undertake a double-blind placebo controlled study to evaluate a novel approach to improving orthostatic hypotension without worsening supine hypertension...
- CIRCULATORY CONTROL IN CHRONIC HYPOTENSIVE STATESROSE ROBERTSON; Fiscal Year: 1990..Both sympathotonic orthostatic hypotension (SOH), which overlaps clinically with "vasoregulatory" or "neurocirculatory" asthenia and a portion of ..
- Bionic Baroreflex System for Blood Pressure ControlAndre Diedrich; Fiscal Year: 2002..with multiple system atrophy (MSA), a sporadic and progressive neurodegenerative disorder, suffer from orthostatic hypotension, postprandial hypotension and supine hypertension...
- ORTHOSTATIC HYPOTENSION IN OLDER PERSONSJEANNE WEI; Fiscal Year: 1992b>Orthostatic hypotension is a major public health problem among the elderly, occurring in 30 percent of persons over the age of 75 years...
- Autonomic Disorders Programs ProjectPhillip Low; Fiscal Year: 2009..Disorders PPG will continue its focus on the pathophysiology of orthostatic intolerance and neurogenic orthostatic hypotension and develop novel therapies in the treatment of autonomic failure...
- Skin Cooling to Improve Orthostatic ToleranceCRAIG CRANDALL; Fiscal Year: 2005Post-space flight orthostatic hypotension/intolerance occurs in 25 to 66 percent of crew members upon returning to a 1 G environment. The mechanism(s) causing this response are not completely understood...
- RBC MASS, ANS INTEGRITY & SYNCOPE SUSCEPTIBILITY IN CFSBarry Hurwitz; Fiscal Year: 2003..infusion at 2 mug/min (and then again at 5 mug/min, if the previous HUT failed to induce orthostatic hypotension) will be performed...
- BAROREFLEXES AND ORTHOSTATISM--FITNESS EFFECTPeter Raven; Fiscal Year: 1993b>Orthostatic hypotension, involving an imbalance between the regulation of vascular volume, cardiac function and vascular responsiveness, has been reported to be more prevalent in endurance (aerobic) exercise trained individuals...
- Cerebral Vasoregulation In Elderly with StrokeVera Novak; Fiscal Year: 2007..Therefore, activities of daily living may induce orthostatic hypotension (OH), posing a risk of cerebral hypoperfusion...
- New Perspectives in Transporter Biology (FASEB Conference)Michael Robinson; Fiscal Year: 2005..lateral sclerosis (ALS), depression, attention deficit hyperactivity disorder (ADHD), diabetes, orthostatic hypotension, cystinuria, cystic fibrosis, HHH syndrome, etc; there is a growing list of 'transporteropathies'...
- Influence of Age on Vestibular Sympathetic ReflexesKEVIN MONAHAN; Fiscal Year: 2002DESCRIPTION (Applicant's abstract): Aging is associated with an increased incidence of orthostatic hypotension in humans. Orthostatic hypotension has been shown to be associated with increased mortality...
- VESTIBULAR-CEREBROVASCULAR INTERACTIONS IN HUMANSJorge Serrador; Fiscal Year: 2005..While the cause of many falls remains unexplained, syncope and orthostatic hypotension are important factors...
- CENTER FOR MULTIDISCIPLENERY STUDIES OF CFS PATHOGENESISNancy Klimas; Fiscal Year: 2002..Certainly two areas of research stand out and are intertwined: the biology of orthostatic hypotension and the biology of reactivity...
- Circulatory Dysfunction in Chronic Fatigue SyndromeJulian Stewart; Fiscal Year: 2004....
- Detecting Endothelial Dysfunction in Renal FailureJulian Stewart; Fiscal Year: 2007..These data will form the basis of future noninvasive prognostic testing and treatment of patients at risk for ECD and can provide a means to follow treatment modalities. [unreadable] [unreadable] [unreadable]..
- HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTIONRoy Freeman; Fiscal Year: 2007..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
- Concept: Stress, Cytokines and Heart Disease in PoliceWARREN FRANKE; Fiscal Year: 2007..The proposed work is significant because it is expected to increase our understanding of the mechanisms underlying the pathogenesis of cardiovascular disease in this high stress occupation. [unreadable] [unreadable] [unreadable]..
- Mesenchymal Stem Cells for Myocardial InfarctionRobert Kloner; Fiscal Year: 2006..abstract_text> ..
- Combat Stress and Cardiovascular Risk Among Aging MenKathryn Rose; Fiscal Year: 2007..Furthermore, they may provide data useful in planning public health intervention programs which target active service and veteran populations. [unreadable] [unreadable]..
- Recall and Survivor Bias: Impact on SES-CVD AssociationsKathryn Rose; Fiscal Year: 2009....
- Autonomic Nervous System in Chronic Fatigue SyndromeItalo Biaggioni; Fiscal Year: 2009....
- Effects of Neighborhood SES on Coronary Heart Disease Burden in CommunitiesKathryn Rose; Fiscal Year: 2008..Furthermore, the findings could be used to plan targeted public health interventions aimed at reducing CHD disparities. [unreadable] [unreadable]..
- PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPEItalo Biaggioni; Fiscal Year: 2003..These studies will be directly applicable to the evaluation and treatment of patients with these incapacitating disorders. ..
- COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSESRobert Kloner; Fiscal Year: 2003....
- Adenosine and Nitric Oxide DeficiencyItalo Biaggioni; Fiscal Year: 2004....
- Biologic Ventricular Assist DeviceRobert Kloner; Fiscal Year: 2004..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
- VESTIBULOSYMPATHETIC REFLEXES IN HUMANSCHESTER RAY; Fiscal Year: 2001....
- VESTIBULOSYMPATHETIC REFLEXES IN HUMANSCHESTER RAY; Fiscal Year: 2005..e., vestibular deficient and idiopathic orthostatic hypotension subjects, and endurance trained athletes)...
- Pathophysiology of Heart Failure with a Normal Ejection Fraction in the ElderlyMathew S Maurer; Fiscal Year: 2010....
- Exercise Training and Vagal-Cardiac Function in ElderlyXiangrong Shi; Fiscal Year: 2005..Our long-term objectives are to understand the albeit regulatory mechanisms of blood pressure and blood volume due to age and to provide the basis for the use of prophylactic measure to improve the quality of human life. ..
- Vestibular Influences on Head Direction Cell ActivityBill Yates; Fiscal Year: 2004..This work may also provide insights into potential effects of peripheral and central vestibular lesions on spatial cognition in humans. ..
- Peripheral Nerve IschemiaPhillip Low; Fiscal Year: 2004..We will then define the therapeutic windows and evaluate the mechanisms of production of hypothermic and antioxidant neuroprotection (Specific aim number 2) from reperfusion injury. ..
- Cardiovascular Causes of Falls/Syncope in the ElderlyMathew Maurer; Fiscal Year: 2005..The research will focus on orthostatic hypotension and carotid sinus hypersensitivity [CSH], which account for a significant percentage of falls/syncope in ..
- Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #Horacio Kaufmann; Fiscal Year: 2010..Their long-term goal is to treat nausea effectively and without side effects, a therapeutic intervention that will markedly improve the quality of life of patients with FD. ..
- Experimental Dysautonomia: Pathogenesis and TreatmentSteven Vernino; Fiscal Year: 2006..unreadable] [unreadable]..
- OTOLITH INFLUENCES ON SYMPATHETIC ACTIVITYHoracio Kaufmann; Fiscal Year: 2004..abstract_text> ..
- DIABETIC AUTONOMIC NEUROPATHYPhillip Low; Fiscal Year: 2001..Whether a patient develops symptoms of orthostatic hypotension depends on cerebral autoregulation, a process whereby cerebral perfusion remains unchanged in the face of ..
- Heart failure, chronic kidney disease, and renin-angiotensin system inhibitionAli Ahmed; Fiscal Year: 2009....
- BRAINSTEM SUBSTRATES OF DOPAMINE MODULATED MOVEMENTSDavid Rye; Fiscal Year: 2002..g., OCD, ADD, Tourette's and schizophrenia, the results will also bear relevance to a wider spectrum of disease. ..
- SLEEP/DOPAMINE PHENOTYPES IN GENETICALLY DISTINCT MICEDavid Rye; Fiscal Year: 2002..abstract_text> ..
- ANTIDEPRESSANT TREATMENT OF MELANCHOLIA IN LATE LIFESteven Roose; Fiscal Year: 2001..Finally, The applicants expect HRQOL to show continued improvement during the continuation phase in euthymic patients and an advantage for the SSRI in HRQOL improvement due to a superior side effect profile. ..
- HRCA/HARVARD RESEARCH NURSING HOMELewis Lipsitz; Fiscal Year: 2008..Our institutional commitments, longstanding collaboration among investigators, track record of productivity, administrative structure, and proven leadership all assure that this program will achieve its stated goals. ..
- Long-term Ambulatory Gait Monitor for Parkinson's DiseaseSteven Moore; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Circuitry of Midbrain Dopamine in Sleep & WakeDavid Rye; Fiscal Year: 2005..g., schizophrenia) and hypodopaminergic (e.g., PD and restless legs/periodic leg movements of sleep). ..
- Wnt Signaling in IBD-Related Colon CancerRANDALL HOLCOMBE; Fiscal Year: 2005..The precise effects of FIPs on Wnt signaling will be defined in vitro, with attention to the potentially disparate responses of different, specific, Fz receptor subtypes. ..
- Multiple Factors Affecting Placebo Response in PDChristopher Goetz; Fiscal Year: 2004..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
- Emergency Linkage to Outpatient Psychiatric CareGlenn Currier; Fiscal Year: 2007..abstract_text> ..
- Circuit Weight Training and Blood Pressure Regulation in PrehypertensionWilliam Cooke; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Neural Circulatory Control: Pregnancy & Ovarian HormonesCHERYL HEESCH; Fiscal Year: 2007..abstract_text> ..
- Interstitial Cystitis Clinical Research Network (ICCRN)J Nickel; Fiscal Year: 2007..site with Dr. Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with IC in clinical strudies and will be a valuable partner in the proposed ICCRN and UCPPSCG. ..
- Impulse Control Disorders in Parkinson's Disease ConferenceMark Stacy; Fiscal Year: 2007..To date, there has not been a workshop or meeting dedicated to the discussion of this evolving field. [unreadable] [unreadable] [unreadable]..
- HARVARD OLDER AMERICANS INDEPENDENCE CENTERLewis Lipsitz; Fiscal Year: 2006..abstract_text> ..
- CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITISJ Nickel; Fiscal Year: 2003..Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially. ..
- COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECTKeith Rasmussen; Fiscal Year: 2005..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..