orthostatic hypotension

Summary

Summary: A drop in blood pressure upon standing or after standing motionless in a static position.

Top Publications

  1. ncbi EFNS guidelines on the diagnosis and management of orthostatic hypotension
    H Lahrmann
    Neurological Department and L Boltzmann Institute for Neurooncology, Kaiser Franz Josef Hospital, Vienna, Austria
    Eur J Neurol 13:930-6. 2006
  2. doi Clinical practice. Neurogenic orthostatic hypotension
    Roy Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 358:615-24. 2008
  3. pmc Management of neurogenic orthostatic hypotension: an update
    Phillip A Low
    Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
    Lancet Neurol 7:451-8. 2008
  4. ncbi Cardiac denervation occurs independent of orthostatic hypotension and impaired heart rate variability in Parkinson's disease
    C A Haensch
    Department of Neurology and Clinical Neurophysiology, HELIOS Klinikum Wuppertal, University of Witten Herdecke, Heusnerstrasse 40, D 42283 Wuppertal, Germany
    Parkinsonism Relat Disord 15:134-7. 2009
  5. pmc Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease
    L M Allcock
    Parkinson s Disease Research Unit, Department of Neurology, Sunderland Royal Hospital and Institute for Ageing and Health, University of Newcastle, Sunderland, UK
    J Neurol Neurosurg Psychiatry 75:1470-1. 2004
  6. ncbi A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension
    Fang Luo
    Hypertension Division, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, China
    Hypertension 54:796-801. 2009
  7. ncbi Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program
    K H Masaki
    Honolulu Heart Program, Kuakini Medical Center, Honolulu, Hawaii, USA
    Circulation 98:2290-5. 1998
  8. ncbi Norepinephrine precursor therapy in neurogenic orthostatic hypotension
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Circulation 108:724-8. 2003
  9. ncbi Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group
    P A Low
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    JAMA 277:1046-51. 1997
  10. ncbi Association between supine hypertension and orthostatic hypotension in autonomic failure
    David S Goldstein
    the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 42:136-42. 2003

Detail Information

Publications275 found, 100 shown here

  1. ncbi EFNS guidelines on the diagnosis and management of orthostatic hypotension
    H Lahrmann
    Neurological Department and L Boltzmann Institute for Neurooncology, Kaiser Franz Josef Hospital, Vienna, Austria
    Eur J Neurol 13:930-6. 2006
    ..Fludrocortisone is a valuable starter drug. Second line drugs include sympathomimetics, such as midodrine, ephedrine, or dihydroxyphenylserine. Supine hypertension has to be considered...
  2. doi Clinical practice. Neurogenic orthostatic hypotension
    Roy Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 358:615-24. 2008
  3. pmc Management of neurogenic orthostatic hypotension: an update
    Phillip A Low
    Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
    Lancet Neurol 7:451-8. 2008
    b>Orthostatic hypotension (OH) is common in elderly people and in patients with disorders such as diabetes and Parkinson's disease. Grading of the severity of OH and its effect on the patient's quality of life are important...
  4. ncbi Cardiac denervation occurs independent of orthostatic hypotension and impaired heart rate variability in Parkinson's disease
    C A Haensch
    Department of Neurology and Clinical Neurophysiology, HELIOS Klinikum Wuppertal, University of Witten Herdecke, Heusnerstrasse 40, D 42283 Wuppertal, Germany
    Parkinsonism Relat Disord 15:134-7. 2009
    ..Here we analyzed the correlation between cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake, orthostatic hypotension and heart rate variability in treated patients with PD...
  5. pmc Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson's disease
    L M Allcock
    Parkinson s Disease Research Unit, Department of Neurology, Sunderland Royal Hospital and Institute for Ageing and Health, University of Newcastle, Sunderland, UK
    J Neurol Neurosurg Psychiatry 75:1470-1. 2004
    The frequency of orthostatic hypotension (OH) in cohorts of patients recruited through hospital Parkinson's disease (PD) clinics ranges from 16% to 58%. However, hospital based cohorts may be subject to ascertainment bias...
  6. ncbi A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension
    Fang Luo
    Hypertension Division, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, China
    Hypertension 54:796-801. 2009
    ..has an impact on the antihypertensive response to hydrochlorothiazide, and is associated with orthostatic hypotension, we performed a case-control study of hypertension (n=1686), a 4-week clinical trial (n=542), and a case-..
  7. ncbi Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program
    K H Masaki
    Honolulu Heart Program, Kuakini Medical Center, Honolulu, Hawaii, USA
    Circulation 98:2290-5. 1998
    Population-based data are unavailable concerning the predictive value of orthostatic hypotension on mortality in ambulatory elderly patients, particularly minority groups.
  8. ncbi Norepinephrine precursor therapy in neurogenic orthostatic hypotension
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Circulation 108:724-8. 2003
    In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture.
  9. ncbi Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group
    P A Low
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    JAMA 277:1046-51. 1997
    ..a 10-mg dose of midodrine 3 times per day in improving blood pressure (BP) and ameliorating symptoms of orthostatic hypotension in patients with neurogenic orthostatic hypotension...
  10. ncbi Association between supine hypertension and orthostatic hypotension in autonomic failure
    David S Goldstein
    the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 42:136-42. 2003
    ..This study explored whether supine hypertension in this setting is associated with orthostatic hypotension (OH), and if so, what mechanisms might underlie this association...
  11. ncbi Orthostatic hypotension and the incidence of coronary heart disease: the Atherosclerosis Risk in Communities study
    K M Rose
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, USA
    Am J Hypertens 13:571-8. 2000
    We examined the association between orthostatic hypotension (OH) at baseline examination (1987-1989) and the incidence of coronary heart disease (CHD) over an average of 6 years, among 12,433 black and white middle-aged men and women ..
  12. ncbi L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure
    C J Mathias
    Neurovascular Medicine Unit, Division of Neuroscience and Psychological Medicine, Imperial College of Science, Technology, and Medicine at St Mary s, London, UK
    Clin Auton Res 11:235-42. 2001
    ..tolerability of increasing doses of L-threo-dihydroxyphenylserine (L-threo-DOPS) in treating symptomatic orthostatic hypotension associated with multiple system atrophy (MSA) and pure autonomic failure (PAF)...
  13. ncbi Orthostatic hypotension, balance and falls in Parkinson's disease
    Maarit Matinolli
    Department of Neurology, University of Oulu, Oulu, Finland
    Mov Disord 24:745-51. 2009
    b>Orthostatic hypotension (OH) is a common feature in Parkinson's disease (PD). As the control of balance and gait is already affected by PD per se, OH may further predispose patients to falls and accidents...
  14. ncbi Population-based study on the prevalence and correlates of orthostatic hypotension/hypertension and orthostatic dizziness
    Jin Shang Wu
    Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    Hypertens Res 31:897-904. 2008
    There are no epidemiological studies of orthostatic hypotension (OH)/hypertension (OHT) and orthostatic dizziness (OD) in adults across all age groups...
  15. ncbi Prevalence of orthostatic hypotension
    Phillip A Low
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Auton Res 18:8-13. 2008
    b>Orthostatic hypotension (OH) is defined as a fall in blood pressure of at least 20 mmHg systolic or 10 mmHg diastolic when standing or during head-up tilt testing...
  16. ncbi Symptoms associated with orthostatic hypotension in pure autonomic failure and multiple system atrophy
    C J Mathias
    Neurovascular Medicine Unit, Division of Neurosience and Psychological Medicine, Imperial College School of Medicine at St Mary s Hospital, Praed Street, London W2 INY, UK
    J Neurol 246:893-8. 1999
    The symptoms caused by or relating to orthostatic hypotension (over 20 mmHg systolic blood pressure) were evaluated using a questionnaire in 72 patients with primary chronic autonomic failure, 32 of whom had pure autonomic failure (PAF, ..
  17. pmc Orthostatic hypotension: framework of the syndrome
    Jochanan E Naschitz
    Department of Internal Medicine A, Bnai Zion Medical Center, Haifa, Israel
    Postgrad Med J 83:568-74. 2007
    According to the 1996 consensus definition, orthostatic hypotension (OH) is diagnosed when a fall in systolic blood pressure of at least 20 mm Hg and/or diastolic blood pressure of at least 10 mm Hg within 3 min of standing is recorded...
  18. pmc Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 23:1725-32. 2008
    ..About 40% have neurogenic orthostatic hypotension (NOH), and among PD+NOH patients virtually all have evidence of cardiac sympathetic denervation; however, ..
  19. ncbi Hypotension unawareness in profound orthostatic hypotension
    Steven D Arbogast
    Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Med 122:574-80. 2009
    Clinicians depend on history given by the patients when considering the diagnosis of orthostatic hypotension.
  20. ncbi Are current recommendations to diagnose orthostatic hypotension in Parkinson's disease satisfactory?
    Jenny Jamnadas-Khoda
    School of Health and Related Research, Sheffield University, Sheffield, United Kingdom
    Mov Disord 24:1747-51. 2009
    ..using a questionnaire to verify the reliability of orthostatic symptoms in warning the presence of orthostatic hypotension (OH)...
  21. ncbi Measuring orthostatic hypotension with the Finometer device: is a blood pressure drop of one heartbeat clinically relevant?
    Nathalie van der Velde
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood Press Monit 12:167-71. 2007
    The role of orthostatic hypotension in falls in older people is generally accepted...
  22. ncbi Water drinking in the management of orthostatic intolerance due to orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome
    C J Mathias
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
    Eur J Neurol 11:613-9. 2004
    ..has been shown to raise blood pressure in normal subjects and in patients with autonomic failure who have orthostatic hypotension. However, in normal young subjects, ingestion of approximately 500 ml has no pressor effect; but in older ..
  23. ncbi Acute orthostatic hypotension when starting dopamine agonists in Parkinson's disease
    K Kujawa
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Arch Neurol 57:1461-3. 2000
    To study the frequency and severity of acute orthostatic hypotension (OH) in patients with Parkinson's disease who are starting dopamine agonist therapy.
  24. ncbi High prevalence of orthostatic hypotension in mild dementia
    Hogne Sonnesyn
    Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
    Dement Geriatr Cogn Disord 28:307-13. 2009
    b>Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia.
  25. ncbi Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures
    Christine Schrezenmaier
    Autonomic Disorders Center, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:330-4. 2005
    To compare measured autonomic deficits (composite autonomic severity score [CASS]) with a brief self-report scale we developed to measure severity of symptoms of orthostatic hypotension.
  26. ncbi Orthostatic hypotension and long-term incidence of atrial fibrillation: the Malmö Preventive Project
    A Fedorowski
    Center for Emergency Medicine, Skane University Hospital, Malmo, Sweden
    J Intern Med 268:383-9. 2010
    b>Orthostatic hypotension (OH), a common manifestation of autonomic dysfunction, has been identified as an independent risk factor for all-cause mortality and incident cardiovascular disease...
  27. pmc Orthostatic hypotension and cognitive function: the Atherosclerosis Risk in Communities Study
    Kathryn M Rose
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    Neuroepidemiology 34:1-7. 2010
    To examine the association between orthostatic hypotension (OH) and cognitive function in middle-aged adults.
  28. ncbi Cognitive functioning in orthostatic hypotension due to pure autonomic failure
    Hannah C Heims
    Dept of Neuropsychology, Box 37, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Clin Auton Res 16:113-20. 2006
    ..However, a failure in integrated bodily arousal responses during cognitive behaviours may also contribute to some of the observed deficits...
  29. ncbi Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease
    Kerrie L Schoffer
    Department of Neurology, Royal Brisbane and Women s Hospital, Brisbane, and Department of Medicine, University of Queensland, Australia
    Mov Disord 22:1543-9. 2007
    There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease...
  30. ncbi Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management
    J M Senard
    Laboratory of Medical and Clinical Pharmacology, INSERM U317, Faculty of Medicine, Paul Sabatier University, Toulouse, France
    Drugs Aging 18:495-505. 2001
    b>Orthostatic hypotension is common in elderly patients, and is now considered to be an important prognostic factor for cognitive decline and mortality...
  31. ncbi Orthostatic hypotension as an early finding in Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10 Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892, USA
    Clin Auton Res 16:46-54. 2006
    Patients with Parkinson's disease (PD) commonly have clinically significant orthostatic hypotension (OH)...
  32. ncbi The pathophysiology and diagnosis of orthostatic hypotension
    David Robertson
    Autonomic Dysfunction Center, Depts of Medicine and Pharmacology, Vanderbilt University, AA 3228 Medical Center North, 1161 21st Avenue South, Nashville, TN 37323 2195, USA
    Clin Auton Res 18:2-7. 2008
    b>Orthostatic Hypotension (OH) is a common manifestation of blood pressure dysregulation. OH takes a heavy toll on quality of life. It has many potential etiologies, and many effects of aging can increase susceptibility to OH...
  33. ncbi Initial orthostatic hypotension: review of a forgotten condition
    Wouter Wieling
    Department of Internal Medicine, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Clin Sci (Lond) 112:157-65. 2007
    ..An exaggerated transient BP (blood pressure) fall upon standing is the underlying cause. IOH (initial orthostatic hypotension) is defined as a transient BP decrease within 15 s after standing, >40 mmHg SBP (systolic BP) and/or &..
  34. ncbi Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: autonomic symptom and demographic comparison
    Liesl M Allcock
    Institute of Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Mov Disord 21:1851-5. 2006
    The objective of this study was to characterize the phenotypic associations of orthostatic hypotension (OH) in Parkinson's disease (PD)...
  35. ncbi Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam study
    Germaine C Verwoert
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Am Geriatr Soc 56:1816-20. 2008
    To determine the prognostic role of orthostatic hypotension for cardiovascular disease (CVD) and all-cause mortality in elderly people.
  36. ncbi Insular pathology in Parkinson's disease patients with orthostatic hypotension
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Room 4004, 1501 NW 9th Avenue, Miami, FL 33136, USA
    Parkinsonism Relat Disord 13:308-11. 2007
    b>Orthostatic hypotension (OH) in Parkinson's disease (PD) patients may be a significant source of morbidity and discomfort...
  37. ncbi Autoregulatory cerebral vasodilation occurs during orthostatic hypotension in patients with primary autonomic failure
    D R Horowitz
    Department of Neurology, The Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Auton Res 11:363-7. 2001
    ....
  38. ncbi Orthostatic hypotension in de novo Parkinson disease
    Ubaldo Bonuccelli
    Department of Neuroscience, Section of Neurology, Movement Disorders Unit, University of Pisa, Pisa, Italy
    Arch Neurol 60:1400-4. 2003
    It is accepted that orthostatic hypotension is a clinical marker for the diagnosis of multiple system atrophy, but conflicting data indicate that it may also be present in Parkinson disease (PD).
  39. ncbi Erythropoietin, anemia, and orthostatic hypotension: the evidence mounts
    Sunil V Rao
    Clin Auton Res 12:141-3. 2002
  40. ncbi Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure
    Atul Pathak
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Toulouse, France
    Mov Disord 20:1213-9. 2005
    We investigated the effects of high-external-temperature exposure on neurogenic orthostatic hypotension (OH)...
  41. ncbi A clinical, physiology and pharmacology evaluation of orthostatic hypotension in the elderly
    Manish Sahni
    Malcolm Randall VA Medical Center, GRECC, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Int Urol Nephrol 37:669-74. 2005
    b>Orthostatic hypotension is very common in the elderly. It increases morbidity and is an independant predictor of all cause mortality...
  42. ncbi Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance
    Christopher H Gibbons
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 67:28-32. 2006
    To investigate the prevalence, symptoms, and neurophysiologic features of delayed orthostatic hypotension (OH).
  43. ncbi Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromes
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Neuropharmacol 29:97-105. 2006
    Neurogenic orthostatic hypotension (OH) characterizes pure autonomic failure (PAF), multiple system atrophy (MSA), and Parkinson disease (PD) with autonomic failure...
  44. ncbi The treatment of orthostatic hypotension with dihydroxyphenylserine
    R Freeman
    Division of Neurology, New England Deaconess Hospital, Boston, MA 02215
    Clin Neuropharmacol 14:296-304. 1991
    Neurogenic orthostatic hypotension is an incapacitating symptom of central and peripheral autonomic nervous system degeneration...
  45. ncbi A study of orthostatic hypotension in late-life depression
    Jonathan Richardson
    Institute for Ageing and Health, Newcastle University, England, UK
    Am J Geriatr Psychiatry 17:996-9. 2009
    Studies examining vascular risk factors in depression report conflicting evidence but have not assessed orthostatic hypotension, a recently recognized risk factor for white matter hyperintensities.
  46. ncbi Orthostatic hypotension in elderly persons during passive standing: a comparison with young persons
    T Kawaguchi
    College of Nursing Art and Science Hyogo, Akashi, Japan
    J Gerontol A Biol Sci Med Sci 56:M273-80. 2001
    The present study was aimed at clarifying the mechanism of orthostatic hypotension (OH) that occurs in elderly persons and at investigating assisting methods to prevent OH by evaluating changes in autonomic nervous system (ANS) activity ..
  47. pmc Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension
    Richard Imrich
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Parkinsonism Relat Disord 15:122-7. 2009
    Diseases characterized by neurogenic orthostatic hypotension (NOH), such as Parkinson disease (PD) and pure autonomic failure (PAF), are associated with cardiac sympathetic denervation, as reflected by low myocardial concentrations of 6-[..
  48. pmc Urinary dysfunction and orthostatic hypotension in multiple system atrophy: which is the more common and earlier manifestation?
    R Sakakibara
    Uro Neurology Group, Department of Neurology, Chiba University, Japan
    J Neurol Neurosurg Psychiatry 68:65-9. 2000
    Urinary dysfunction and orthostatic hypotension are the prominent autonomic features in multiple system atrophy (MSA)...
  49. ncbi L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension: the European experience
    Christopher J Mathias
    Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, Praed Street, London, W2 1NY, UK
    Clin Auton Res 18:25-9. 2008
    Neurogenic orthostatic hypotension is a cardinal feature of generalised autonomic failure and commonly is the presenting sign in patients with primary autonomic failure...
  50. ncbi Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency
    I Biaggioni
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Lancet 2:1170-2. 1987
    ..was given by mouth in a single-blind, placebo-controlled trial to two patients with orthostatic hypotension due to dopamine-beta-hydroxylase deficiency, in the hope of providing noradrenaline by endogenous ..
  51. ncbi Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation
    D Robertson
    Department of Pharmacology, Vanderbilt University, Nashville, Tenn 37232 2195
    Hypertension 18:1-8. 1991
    ..and hypotension, but survivors sometimes cope relatively well until late childhood when overwhelming orthostatic hypotension profoundly limits their activities. The hypotension may be so severe that clonic seizures supervene...
  52. ncbi Current pharmacologic treatment for orthostatic hypotension
    Roy Freeman
    Dept of Neurology Harvard Medical School, Center for Autonomic and Peripheral Nerve Disorders Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Clin Auton Res 18:14-8. 2008
    b>Orthostatic hypotension is treated effectively with the combined use of non-pharmacological and pharmacological interventions...
  53. ncbi Cognition and hopelessness in association with subsyndromal orthostatic hypotension
    Jadwiga Czajkowska
    Department of Medicine, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    J Gerontol A Biol Sci Med Sci 65:873-9. 2010
    ..The lack of effective orthostatic BP regulation is a symptom for various problems, including fatigue, depression, anxiety, and reduced attention...
  54. ncbi Cerebrospinal fluid levels of catechols in patients with neurogenic orthostatic hypotension
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 6N252, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, U S A
    Clin Sci (Lond) 104:649-54. 2003
    In multiple system atrophy (MSA) and pure autonomic failure (PAF), orthostatic hypotension (OH) results from deficient noradrenaline release from sympathetic nerves during standing...
  55. pmc Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure
    Cyndya Shibao
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Hypertension 56:847-51. 2010
    b>Orthostatic hypotension affects patients with autonomic failure producing considerable disability because of presyncopal symptoms...
  56. pmc Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension
    W Singer
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurol Neurosurg Psychiatry 74:1294-8. 2003
    Pharmacological treatment of orthostatic hypotension is often limited because of troublesome supine hypertension.
  57. ncbi Postural blood pressure changes and orthostatic hypotension in the elderly patient: impact of antihypertensive medications
    Ihab Hajjar
    Division of Geriatrics, Department of Internal Medicine, Palmetto Health Richland and University of South Carolina, Columbia, South Carolina 29203, USA
    Drugs Aging 22:55-68. 2005
    ..This predisposes elderly patients to significant changes in blood pressure upon standing and orthostatic hypotension (OH). The prevalence of OH varies according to the population being studied...
  58. ncbi L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US experience
    Horacio Kaufmann
    Dysautonomia Research Laboratory, New York University School of Medicine, 530 First Avenue, New York, NY 10016, USA
    Clin Auton Res 18:19-24. 2008
    Neurogenic orthostatic hypotension results from failure to release norepinephrine, the neurotransmitter of sympathetic postganglionic neurons, appropriately upon standing...
  59. ncbi Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension: independence from levodopa treatment
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 46:1333-9. 2005
    Patients with Parkinson disease often have orthostatic hypotension. Neurocirculatory abnormalities underlying orthostatic hypotension might reflect levodopa treatment...
  60. ncbi Arterial stiffness as the candidate underlying mechanism for postural blood pressure changes and orthostatic hypotension in older adults: the Rotterdam Study
    Francesco U S Mattace-Raso
    Section of Geriatric Medicine, Department of Internal Medicine bDepartment of Epidemiology and Biostatistics, The Netherlands
    J Hypertens 24:339-44. 2006
    To investigate whether arterial stiffening, one of the characteristics of the aging vascular system, is associated with orthostatic hypotension.
  61. pmc Preventing and treating orthostatic hypotension: As easy as A, B, C
    Juan J Figueroa
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Cleve Clin J Med 77:298-306. 2010
    b>Orthostatic hypotension is a chronic, debilitating illness that is difficult to treat...
  62. ncbi Selegiline in the treatment of Parkinson's disease: its impact on orthostatic hypotension
    K F Bhattacharya
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Parkinsonism Relat Disord 9:221-4. 2003
    ..with levodopa/carbidopa in patients with Parkinson's disease, is associated with more pronounced orthostatic hypotension than treatment with levodopa/carbidopa alone...
  63. ncbi Neurogenic orthostatic hypotension: chasing "the fall"
    D Gupta
    Department of Neurology, Sree Chitra Tirunal Institute for Medical Science and Technology, Trivandrum, Kerala, India
    Postgrad Med J 84:6-14. 2008
    b>Orthostatic hypotension (OH) is a frequently encountered problem affecting nearly 30% of the population aged more than 60 years...
  64. pmc Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson's disease or multiple system atrophy with observations on orthostatic hypotension
    I F Hussain
    Uro-Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 71:371-4. 2001
    ..Two were already known to have orthostatic hypotension and were receiving treatment with ephedrine and midodrine but the third had asymptomatic hypotension...
  65. ncbi Sitting and standing blood pressure measurements are not accurate for the diagnosis of orthostatic hypotension
    J Cooke
    Clinical Age Assessment Unit, Mid Western Regional Hospital, Dooradoyle, Limerick, Ireland
    QJM 102:335-9. 2009
    b>Orthostatic hypotension (OH) is associated with troublesome symptoms and increased mortality. It is treatable and deserving of accurate diagnosis. This can be time consuming...
  66. ncbi Effect of physical countermaneuvers on orthostatic hypotension in familial dysautonomia
    Marcin Tutaj
    Department of Neurology, Jagiellonian University, Botaniczna 3, 31503, Krakow, Poland
    J Neurol 253:65-72. 2006
    Familial dysautonomia (FD) patients frequently experience debilitating orthostatic hypotension. Since physical countermaneuvers can increase blood pressure (BP) in other groups of patients with orthostatic hypotension, we evaluated the ..
  67. ncbi Orthostatic hypotension following spinal cord injury: impact on the use of standing apparatus
    Ramesh Chelvarajah
    Spinal Research Centre, Royal National Orthopaedic Hospital, Stanmore, UK
    NeuroRehabilitation 24:237-42. 2009
    Upright posture confers numerous medical and social benefits to a spinal cord injured (SCI) patient. Doing so is limited by symptoms of orthostatic hypotension. This is a common secondary impairment among tetraplegic sufferers.
  68. ncbi Effects of atrial tachypacing on symptoms and blood pressure in severe orthostatic hypotension
    Ritsuko Kohno
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Pacing Clin Electrophysiol 30:S203-6. 2007
    The treatment of severe orthostatic hypotension (OH) is currently unsatisfactory and usually includes various pharmaceuticals to expand the blood volume and promote peripheral vasoconstriction...
  69. ncbi Pharmacology of orthostatic hypotension in Parkinson's disease: from pathophysiology to management
    Atul Pathak
    Laboratoire de Pharmacologie Medicale et Clinique, INSERM U586, 37 Allees Jules Guesde, 31073 Toulouse Cedex, France
    Expert Rev Cardiovasc Ther 2:393-403. 2004
    b>Orthostatic hypotension is highly prevalent in the elderly, and affects up to 20% of patients with Parkinson's disease...
  70. ncbi The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial
    R Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Neurology 53:2151-7. 1999
    To study the therapeutic effect and mechanism of action of 3,4-DL-threodihydroxyphenylserine (DL-DOPS) in neurogenic orthostatic hypotension.
  71. ncbi Incidence and outcome of orthostatic hypotension in stroke patients undergoing rehabilitation
    Keng He Kong
    Tan Tock Seng Hospital Rehabilitation Centre, Ang Mo Kio Community Hospital, Singapore
    Arch Phys Med Rehabil 84:559-62. 2003
    To document the incidence and outcome of orthostatic hypotension in stroke patients undergoing rehabilitation and to determine clinical variables associated with it.
  72. ncbi Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension
    Yasuharu Tabara
    Department of Geriatric Medicine, Ehime University School of Medicine, Shigenobu cho, Onsen gun, Ehime, Japan
    J Hypertens 20:651-6. 2002
    The genetic background of orthostatic hypotension, an important risk factor for future cardiovascular morbidity and mortality, was investigated.
  73. ncbi Early detection of orthostatic hypotension by quantitative sudomotor axon reflex test (QSART) in type 2 diabetic patients
    Hiroshi Itoh
    Second Department of Medicine, Asahikawa Medical College, Asahikawa
    Intern Med 42:560-4. 2003
    b>Orthostatic hypotension is caused by autonomic nerve dysfunction, mainly by severe sympathetic nerve dysfunction in diabetic patients. Diabetes affects the peripheral nerves in a length-dependent manner...
  74. ncbi The association between orthostatic hypotension and medication use in the British Women's Heart and Health Study
    Shahrul Kamaruzzaman
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Age Ageing 39:51-6. 2010
    to determine the prevalence of orthostatic hypotension (OH) and associations with medication use in community-dwelling older women.
  75. ncbi Drug treatment of orthostatic hypotension and vasovagal syncope
    William H Frishman
    Department of Medicine, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Heart Dis 5:49-64. 2003
    b>Orthostatic hypotension is a common problem, estimated to occur in 5 out of every 1000 individuals and in as many as 7% to 17% of patients in an acute care setting...
  76. ncbi [Prevalence of orthostatic hypotension in elderly hypertensive patients in primary care]
    L Vara González
    Centro de Salud La Marina y Gerencia de Atención Primaria Médico de Familia Centro de Salud La Marina Santander Cantabria
    Aten Primaria 28:151-7. 2001
    To find the prevalence of orthostatic hypotension (OH) and associated factors in elderly hypertensive patients in a primary care setting.
  77. ncbi Orthostatic hypotension predicts vascular death in older diabetic patients
    Heikki Luukinen
    Department of Public Health Science and General Practice, University of Oulu, Unit of General Practice, Oulu University Hospital, PB 5000, FIN 90014, Oulu, Finland
    Diabetes Res Clin Pract 67:163-6. 2005
    Diastolic orthostatic hypotension measured 1 min after standing up (OH-D1), and systolic OH measured 3 min after standing up (OH-S3) increase vascular mortality risk among older adults...
  78. ncbi Orthostatic hypotension in a case with multiple sclerosis
    R Sakakibara
    Department of Neurology, Chiba University School of Medicine, Japan
    Clin Auton Res 7:163-5. 1997
    ..Head-up tilt testing confirmed orthostatic hypotension with relative preservation of the heart rate increase...
  79. ncbi Orthostatic hypotension in the healthy elderly
    T Atli
    Ankara University School of Medicine, Department of Geriatric Medicine, 06110 Cebeci, Ankara, Turkey
    Arch Gerontol Geriatr 43:313-7. 2006
    b>Orthostatic hypotension (OH) is a common problem in elderly people causing several complications such as falls and fractures...
  80. ncbi Orthostatic hypotension-related hospitalizations in the United States
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37212, USA
    Am J Med 120:975-80. 2007
    b>Orthostatic hypotension has been commonly described in elderly persons and is associated with an increased risk of falls, syncope, and cerebrovascular events...
  81. ncbi Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotension
    Satish R Raj
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Hypertension 48:329-34. 2006
    b>Orthostatic hypotension (OH) can cause syncope that is difficult to treat. We have found that 473 mL (16 oz) of water can increase systolic blood pressure (SBP) by > 30 mm Hg in many OH patients (the gastropressor response)...
  82. ncbi What is the minimum duration of head-up tilt necessary to detect orthostatic hypotension?
    Jade A Gehrking
    Dept of Neurology, Mayo Clinic, Rochester MN 55905, USA
    Clin Auton Res 15:71-5. 2005
    There is uncertainty as to the minimum duration of head-up tilt (HUT) needed to detect orthostatic hypotension (OH). The orthostatic duration has variably been recommended to be 1, 2, 3, and 5 minutes...
  83. ncbi Characteristics of 100 consecutive patients presenting with orthostatic hypotension
    A Ahsan Ejaz
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
    Mayo Clin Proc 79:890-4. 2004
    To elucidate the demographic and clinical characteristics of a consecutive series of patients who presented for evaluation of orthostatic hypotension.
  84. ncbi 24-hour blood pressure monitoring in the evaluation of supine hypertension and orthostatic hypotension
    A Ahsan Ejaz
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32608, USA
    J Clin Hypertens (Greenwich) 9:952-5. 2007
    The presence of orthostatic hypotension has been shown to be a significant, independent predictor of all-cause mortality...
  85. ncbi Cerebral blood flow response and its association with symptoms during orthostatic hypotension
    Caroline A Rickards
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Aviat Space Environ Med 78:653-8. 2007
    The preservation of cerebral blood flow with orthostatic hypotension (e.g., following prolonged bed rest or microgravity exposure) is vital for the attenuation of symptoms and the maintenance of consciousness...
  86. ncbi Association between supine cerebral perfusion and symptomatic orthostatic hypotension
    Matthias J P van Osch
    Department of Radiology, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuroimage 27:789-94. 2005
    ..investigate whether the supine resting perfusion of brain tissue in symptomatic patients suffering from orthostatic hypotension (OH) is changed compared to control subjects and whether an association exists between the resting ..
  87. ncbi Initial orthostatic hypotension at high altitude
    Kate N Thomas
    University of Otago, Dunedin, New Zealand
    High Alt Med Biol 11:163-7. 2010
    ..min(-1), p = 0.01). Reduced MCAv at 3 min was comparable at sea level and altitude (both -16%). These data indicate that initial cardiovascular and cerebrovascular responses to standing are unaltered when partially acclimatized to HA...
  88. ncbi Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) Study
    Kathryn M Rose
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Circulation 114:630-6. 2006
    An association between orthostatic hypotension (OH) and mortality has been reported, but studies are limited to older adults or high-risk populations.
  89. pmc DBH gene variants that cause low plasma dopamine beta hydroxylase with or without a severe orthostatic syndrome
    J Deinum
    J Med Genet 41:e38. 2004
  90. ncbi Prognosis of diastolic and systolic orthostatic hypotension in older persons
    H Luukinen
    Department of Public Health Science and General Practice, University of Oulu, Oulu University Hospital, Finland
    Arch Intern Med 159:273-80. 1999
    b>Orthostatic hypotension (OH) predicts mortality in hypertensive persons with diabetes mellitus, but no increase in mortality has been found among random samples of home-dwelling persons with OH...
  91. ncbi Orthostatic hypotension
    John G Bradley
    Department of Family and Community Medicine, Southern Illinois University School of Medicine, Decatur, Illinois 62526, USA
    Am Fam Physician 68:2393-8. 2003
    b>Orthostatic hypotension is a physical finding defined by the American Autonomic Society and the American Academy of Neurology as a systolic blood pressure decrease of at least 20 mm Hg or a diastolic blood pressure decrease of at least ..
  92. ncbi Impairment of cerebral autoregulation in diabetic patients with cardiovascular autonomic neuropathy and orthostatic hypotension
    B N Mankovsky
    Institute of Endocrinology and Metabolism, Kiev, Ukraine
    Diabet Med 20:119-26. 2003
    ..However, the contribution of cardiovascular diabetic autonomic neuropathy and orthostatic hypotension to the pathogenesis of such disturbances is not known...
  93. ncbi Lower limb and abdominal compression bandages prevent progressive orthostatic hypotension in elderly persons: a randomized single-blind controlled study
    Cristian Podoleanu
    Cardiologie Clinica Medicala 4, Spitalul Clinic de Urgenta, University Hospital, Targu Mures, Romania
    J Am Coll Cardiol 48:1425-32. 2006
    ..This study sought to assess the efficacy of compression bandage of legs and abdomen in preventing hypotension and symptoms...
  94. ncbi Orthostatic hypotension due to autonomic disorders in the hypertension clinic
    George A Mansoor
    Section of Hypertension and Vascular Diseases, University of Connecticut Health Center, Farmington, Connecticut, USA
    Am J Hypertens 19:319-26. 2006
    Hypertension specialists are consulted regarding orthostatic hypotension (OH) or the combination of OH with supine hypertension. These clinical presentations are often associated with a variety of underlying autonomic disorders...
  95. ncbi Treatment of post-dialytic orthostatic hypotension with an inflatable abdominal band in hemodialysis patients
    N Yamamoto
    First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Kidney Int 70:1793-800. 2006
    ..abdominal compression with an inflatable abdominal band, a device we developed, improved post-dialytic orthostatic hypotension (OH) in hemodialysis (HD) patients...
  96. ncbi Pathophysiology, diagnosis, and treatment of orthostatic hypotension and vasovagal syncope
    Marvin S Medow
    Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
    Cardiol Rev 16:4-20. 2008
    b>Orthostatic hypotension (OH) occurs in 0.5% of individuals and as many as 7-17% of patients in acute care settings...
  97. ncbi Plasma volume restoration with salt tablets and water after bed rest prevents orthostatic hypotension and changes in supine hemodynamic and endocrine variables
    Wendy W Waters
    Human Adaptation and Countermeasures Office, Wyle Laboratories, Inc, Houston, Texas, USA
    Am J Physiol Heart Circ Physiol 288:H839-47. 2005
    ..bed rest would result in an absence of hemodynamic and endocrine changes and a reduced incidence of orthostatic hypotension. In 10 men, we measured changes from pre-bed-rest to post-bed-rest in venous and arterial pressures; ..
  98. ncbi Orthostatic hypotension as cause of syncope in patients older than 65 years admitted to emergency departments for transient loss of consciousness
    Chiara Mussi
    Department of Geriatrics, University of Modena and Reggio Emilia, Italy
    J Gerontol A Biol Sci Med Sci 64:801-6. 2009
    Syncope due to orthostatic hypotension (OH) refers to loss of consciousness caused by hypotension induced by the upright position; it is an important risk factor for fall-related physical injuries, especially in the elderly adults...
  99. ncbi Postural changes in blood pressure and the prevalence of orthostatic hypotension among home-dwelling elderly aged 75 years or older
    P Hiitola
    Department of Social Pharmacy, University of Kuopio, Kuopio, Finland
    J Hum Hypertens 23:33-9. 2009
    ..investigates the postural changes in blood pressure (BP) and heart rate and assesses the prevalence of orthostatic hypotension (OH) and its associations with the medicines used by an elderly population...
  100. ncbi Orthostatic hypotension in the elderly: diagnosis and treatment
    Vishal Gupta
    Beth Israel Deaconess Medical Center, Hebrew SeniorLife, and Harvard Medical School, Boston, Mass 02131, USA
    Am J Med 120:841-7. 2007
    b>Orthostatic hypotension is a common problem among elderly patients, associated with significant morbidity and mortality...
  101. ncbi Orthostatic hypotension in genetically related hypertensive and normotensive individuals
    Artur Fedorowski
    Department of Medicine, Malmo University Hospital, Malmo, Sweden
    J Hypertens 27:976-82. 2009
    Prevalence and determinants of orthostatic hypotension remain largely unexplored in younger individuals without significant burden of chronic diseases.

Research Grants62

  1. Respiratory motor control and blood pressure regulation after spinal cord injury
    ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013
    ..pooling in the lower body during upright posture leads to a further decrease in blood pressure known as orthostatic hypotension. These conditions severely impact the overall health of SCI individuals, delay their participation in ..
  2. Central Endocannabinoid System Dysfunction and Hypertension
    Jeanne L Seagard; Fiscal Year: 2013
    ..of the baroreflex is underscored by the consequences of impaired baroreflex function - volatile BP, orthostatic hypotension, and occasionally malignant vagotonia...
  3. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..during the blood pressure assessments because several smaller studies report an increased prevalence of orthostatic hypotension among individuals with tetraplegia (2, 5, 11)...
  4. Intrathecal therapy for autonomic dysreflexia
    Paul C Dolber; Fiscal Year: 2013
    ..by visceral distension in rats four weeks after T4 spinal cord transection, as well as their effect on orthostatic hypotension. Specific aim 1 does so for acute intrathecal delivery of both nonselective and selective agonists to the ..
  5. Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging
    Farzaneh A Sorond; Fiscal Year: 2010
    ..linked to hypoxic-ischemic injury, such as cerebral microvascular disease, autonomic failure with orthostatic hypotension, stroke, dementia and congestive heart failure...
  6. Neuropeptide Regulation Vasopressin/Oxytocin Secretion
    CELIA SLADEK; Fiscal Year: 2006
    ..Inadequate or inappropriate VP secretion contributes to pathologies such as orthostatic hypotension and congestive heart failure...
  7. Pathogenesis and Diagnosis of Multiple System Atrophy (P01)
    Phillip A Low; Fiscal Year: 2013
    ..additionally undertake a double-blind placebo controlled study to evaluate a novel approach to improving orthostatic hypotension without worsening supine hypertension...
  8. CIRCULATORY CONTROL IN CHRONIC HYPOTENSIVE STATES
    ROSE ROBERTSON; Fiscal Year: 1990
    ..Both sympathotonic orthostatic hypotension (SOH), which overlaps clinically with "vasoregulatory" or "neurocirculatory" asthenia and a portion of ..
  9. Bionic Baroreflex System for Blood Pressure Control
    Andre Diedrich; Fiscal Year: 2002
    ..with multiple system atrophy (MSA), a sporadic and progressive neurodegenerative disorder, suffer from orthostatic hypotension, postprandial hypotension and supine hypertension...
  10. ORTHOSTATIC HYPOTENSION IN OLDER PERSONS
    JEANNE WEI; Fiscal Year: 1992
    b>Orthostatic hypotension is a major public health problem among the elderly, occurring in 30 percent of persons over the age of 75 years...
  11. Autonomic Disorders Programs Project
    Phillip Low; Fiscal Year: 2009
    ..Disorders PPG will continue its focus on the pathophysiology of orthostatic intolerance and neurogenic orthostatic hypotension and develop novel therapies in the treatment of autonomic failure...
  12. Skin Cooling to Improve Orthostatic Tolerance
    CRAIG CRANDALL; Fiscal Year: 2005
    Post-space flight orthostatic hypotension/intolerance occurs in 25 to 66 percent of crew members upon returning to a 1 G environment. The mechanism(s) causing this response are not completely understood...
  13. RBC MASS, ANS INTEGRITY & SYNCOPE SUSCEPTIBILITY IN CFS
    Barry Hurwitz; Fiscal Year: 2003
    ..infusion at 2 mug/min (and then again at 5 mug/min, if the previous HUT failed to induce orthostatic hypotension) will be performed...
  14. BAROREFLEXES AND ORTHOSTATISM--FITNESS EFFECT
    Peter Raven; Fiscal Year: 1993
    b>Orthostatic hypotension, involving an imbalance between the regulation of vascular volume, cardiac function and vascular responsiveness, has been reported to be more prevalent in endurance (aerobic) exercise trained individuals...
  15. Cerebral Vasoregulation In Elderly with Stroke
    Vera Novak; Fiscal Year: 2007
    ..Therefore, activities of daily living may induce orthostatic hypotension (OH), posing a risk of cerebral hypoperfusion...
  16. New Perspectives in Transporter Biology (FASEB Conference)
    Michael Robinson; Fiscal Year: 2005
    ..lateral sclerosis (ALS), depression, attention deficit hyperactivity disorder (ADHD), diabetes, orthostatic hypotension, cystinuria, cystic fibrosis, HHH syndrome, etc; there is a growing list of 'transporteropathies'...
  17. Influence of Age on Vestibular Sympathetic Reflexes
    KEVIN MONAHAN; Fiscal Year: 2002
    DESCRIPTION (Applicant's abstract): Aging is associated with an increased incidence of orthostatic hypotension in humans. Orthostatic hypotension has been shown to be associated with increased mortality...
  18. VESTIBULAR-CEREBROVASCULAR INTERACTIONS IN HUMANS
    Jorge Serrador; Fiscal Year: 2005
    ..While the cause of many falls remains unexplained, syncope and orthostatic hypotension are important factors...
  19. CENTER FOR MULTIDISCIPLENERY STUDIES OF CFS PATHOGENESIS
    Nancy Klimas; Fiscal Year: 2002
    ..Certainly two areas of research stand out and are intertwined: the biology of orthostatic hypotension and the biology of reactivity...
  20. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ....
  21. Detecting Endothelial Dysfunction in Renal Failure
    Julian Stewart; Fiscal Year: 2007
    ..These data will form the basis of future noninvasive prognostic testing and treatment of patients at risk for ECD and can provide a means to follow treatment modalities. [unreadable] [unreadable] [unreadable]..
  22. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
  23. Concept: Stress, Cytokines and Heart Disease in Police
    WARREN FRANKE; Fiscal Year: 2007
    ..The proposed work is significant because it is expected to increase our understanding of the mechanisms underlying the pathogenesis of cardiovascular disease in this high stress occupation. [unreadable] [unreadable] [unreadable]..
  24. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..abstract_text> ..
  25. Combat Stress and Cardiovascular Risk Among Aging Men
    Kathryn Rose; Fiscal Year: 2007
    ..Furthermore, they may provide data useful in planning public health intervention programs which target active service and veteran populations. [unreadable] [unreadable]..
  26. Recall and Survivor Bias: Impact on SES-CVD Associations
    Kathryn Rose; Fiscal Year: 2009
    ....
  27. Autonomic Nervous System in Chronic Fatigue Syndrome
    Italo Biaggioni; Fiscal Year: 2009
    ....
  28. Effects of Neighborhood SES on Coronary Heart Disease Burden in Communities
    Kathryn Rose; Fiscal Year: 2008
    ..Furthermore, the findings could be used to plan targeted public health interventions aimed at reducing CHD disparities. [unreadable] [unreadable]..
  29. PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPE
    Italo Biaggioni; Fiscal Year: 2003
    ..These studies will be directly applicable to the evaluation and treatment of patients with these incapacitating disorders. ..
  30. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
    ....
  31. Adenosine and Nitric Oxide Deficiency
    Italo Biaggioni; Fiscal Year: 2004
    ....
  32. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
  33. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2001
    ....
  34. VESTIBULOSYMPATHETIC REFLEXES IN HUMANS
    CHESTER RAY; Fiscal Year: 2005
    ..e., vestibular deficient and idiopathic orthostatic hypotension subjects, and endurance trained athletes)...
  35. Pathophysiology of Heart Failure with a Normal Ejection Fraction in the Elderly
    Mathew S Maurer; Fiscal Year: 2010
    ....
  36. Exercise Training and Vagal-Cardiac Function in Elderly
    Xiangrong Shi; Fiscal Year: 2005
    ..Our long-term objectives are to understand the albeit regulatory mechanisms of blood pressure and blood volume due to age and to provide the basis for the use of prophylactic measure to improve the quality of human life. ..
  37. Vestibular Influences on Head Direction Cell Activity
    Bill Yates; Fiscal Year: 2004
    ..This work may also provide insights into potential effects of peripheral and central vestibular lesions on spatial cognition in humans. ..
  38. Peripheral Nerve Ischemia
    Phillip Low; Fiscal Year: 2004
    ..We will then define the therapeutic windows and evaluate the mechanisms of production of hypothermic and antioxidant neuroprotection (Specific aim number 2) from reperfusion injury. ..
  39. Cardiovascular Causes of Falls/Syncope in the Elderly
    Mathew Maurer; Fiscal Year: 2005
    ..The research will focus on orthostatic hypotension and carotid sinus hypersensitivity [CSH], which account for a significant percentage of falls/syncope in ..
  40. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
    ..Their long-term goal is to treat nausea effectively and without side effects, a therapeutic intervention that will markedly improve the quality of life of patients with FD. ..
  41. Experimental Dysautonomia: Pathogenesis and Treatment
    Steven Vernino; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  42. OTOLITH INFLUENCES ON SYMPATHETIC ACTIVITY
    Horacio Kaufmann; Fiscal Year: 2004
    ..abstract_text> ..
  43. DIABETIC AUTONOMIC NEUROPATHY
    Phillip Low; Fiscal Year: 2001
    ..Whether a patient develops symptoms of orthostatic hypotension depends on cerebral autoregulation, a process whereby cerebral perfusion remains unchanged in the face of ..
  44. Heart failure, chronic kidney disease, and renin-angiotensin system inhibition
    Ali Ahmed; Fiscal Year: 2009
    ....
  45. BRAINSTEM SUBSTRATES OF DOPAMINE MODULATED MOVEMENTS
    David Rye; Fiscal Year: 2002
    ..g., OCD, ADD, Tourette's and schizophrenia, the results will also bear relevance to a wider spectrum of disease. ..
  46. SLEEP/DOPAMINE PHENOTYPES IN GENETICALLY DISTINCT MICE
    David Rye; Fiscal Year: 2002
    ..abstract_text> ..
  47. ANTIDEPRESSANT TREATMENT OF MELANCHOLIA IN LATE LIFE
    Steven Roose; Fiscal Year: 2001
    ..Finally, The applicants expect HRQOL to show continued improvement during the continuation phase in euthymic patients and an advantage for the SSRI in HRQOL improvement due to a superior side effect profile. ..
  48. HRCA/HARVARD RESEARCH NURSING HOME
    Lewis Lipsitz; Fiscal Year: 2008
    ..Our institutional commitments, longstanding collaboration among investigators, track record of productivity, administrative structure, and proven leadership all assure that this program will achieve its stated goals. ..
  49. Long-term Ambulatory Gait Monitor for Parkinson's Disease
    Steven Moore; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  50. Circuitry of Midbrain Dopamine in Sleep & Wake
    David Rye; Fiscal Year: 2005
    ..g., schizophrenia) and hypodopaminergic (e.g., PD and restless legs/periodic leg movements of sleep). ..
  51. Wnt Signaling in IBD-Related Colon Cancer
    RANDALL HOLCOMBE; Fiscal Year: 2005
    ..The precise effects of FIPs on Wnt signaling will be defined in vitro, with attention to the potentially disparate responses of different, specific, Fz receptor subtypes. ..
  52. Multiple Factors Affecting Placebo Response in PD
    Christopher Goetz; Fiscal Year: 2004
    ..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
  53. Emergency Linkage to Outpatient Psychiatric Care
    Glenn Currier; Fiscal Year: 2007
    ..abstract_text> ..
  54. Circuit Weight Training and Blood Pressure Regulation in Prehypertension
    William Cooke; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. Neural Circulatory Control: Pregnancy & Ovarian Hormones
    CHERYL HEESCH; Fiscal Year: 2007
    ..abstract_text> ..
  56. Interstitial Cystitis Clinical Research Network (ICCRN)
    J Nickel; Fiscal Year: 2007
    ..site with Dr. Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with IC in clinical strudies and will be a valuable partner in the proposed ICCRN and UCPPSCG. ..
  57. Impulse Control Disorders in Parkinson's Disease Conference
    Mark Stacy; Fiscal Year: 2007
    ..To date, there has not been a workshop or meeting dedicated to the discussion of this evolving field. [unreadable] [unreadable] [unreadable]..
  58. HARVARD OLDER AMERICANS INDEPENDENCE CENTER
    Lewis Lipsitz; Fiscal Year: 2006
    ..abstract_text> ..
  59. CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITIS
    J Nickel; Fiscal Year: 2003
    ..Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially. ..
  60. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..