hypotension

Summary

Summary: Abnormally low blood pressure seen in shock but not necessarily indicative of it. (Dorland, 28th ed)

Top Publications

  1. ncbi Pre-hospital endotracheal intubation and positive pressure ventilation is associated with hypotension and decreased survival in hypovolemic trauma patients: an analysis of the National Trauma Data Bank
    Shahid Shafi
    Division of Burns, Trauma and Surgical Critical Care, Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX 75390 9158, USA
    J Trauma 59:1140-5; discussion 1145-7. 2005
  2. ncbi Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Crit Care Med 34:1589-96. 2006
  3. ncbi Predictors of hypotension after induction of general anesthesia
    David L Reich
    Department of Anesthesiology, Mount Sinai Medical Center, Box 1010, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Anesth Analg 101:622-8, table of contents. 2005
  4. pmc Hemofiltration and hemodiafiltration reduce intradialytic hypotension in ESRD
    Francesco Locatelli
    Department of Nephrology and Dialysis, Ospedale Alessandro Manzoni, Lecco, Italy
    J Am Soc Nephrol 21:1798-807. 2010
  5. doi Blast-induced brain injury and posttraumatic hypotension and hypoxemia
    Douglas S DeWitt
    Moody Center for Traumatic Brain and Spinal Cord Injury Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0830, USA
    J Neurotrauma 26:877-87. 2009
  6. pmc The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers
    Alissa J Wright
    Department of Medicine, University of Toronto, Ont, Canada
    CMAJ 183:303-7. 2011
  7. doi Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy
    Barbara Schreier
    Julius Bernstein Institute of Physiology, Medical Faculty, University of Halle Wittenberg, Halle, Germany
    Hypertension 61:333-40. 2013
  8. ncbi Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia
    T Sugaya
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan
    J Biol Chem 270:18719-22. 1995
  9. ncbi Incidence of intraoperative hypotension as a function of the chosen definition: literature definitions applied to a retrospective cohort using automated data collection
    Jilles B Bijker
    Department of Perioperative Care and Emergency Medicine, University Medical Center Utrecht, The Netherlands
    Anesthesiology 107:213-20. 2007
  10. doi The main determinant of hypotension in nitroglycerine tilt-induced vasovagal syncope
    Gerardo Nigro
    Chair of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy
    Pacing Clin Electrophysiol 35:739-48. 2012

Detail Information

Publications424 found, 100 shown here

  1. ncbi Pre-hospital endotracheal intubation and positive pressure ventilation is associated with hypotension and decreased survival in hypovolemic trauma patients: an analysis of the National Trauma Data Bank
    Shahid Shafi
    Division of Burns, Trauma and Surgical Critical Care, Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX 75390 9158, USA
    J Trauma 59:1140-5; discussion 1145-7. 2005
    ..An alternative hypothesis is that positive pressure ventilation increases mortality because positive pressure ventilation causes hypotension in severely injured hypovolemic patients.
  2. ncbi Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Crit Care Med 34:1589-96. 2006
    To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock.
  3. ncbi Predictors of hypotension after induction of general anesthesia
    David L Reich
    Department of Anesthesiology, Mount Sinai Medical Center, Box 1010, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Anesth Analg 101:622-8, table of contents. 2005
    b>Hypotension after induction of general anesthesia is a common event. In the current investigation, we sought to identify the predictors of clinically significant hypotension after the induction of general anesthesia...
  4. pmc Hemofiltration and hemodiafiltration reduce intradialytic hypotension in ESRD
    Francesco Locatelli
    Department of Nephrology and Dialysis, Ospedale Alessandro Manzoni, Lecco, Italy
    J Am Soc Nephrol 21:1798-807. 2010
    Symptomatic intradialytic hypotension is a common complication of hemodialysis (HD). The application of convective therapies to the outpatient setting may improve outcomes, including intradialytic hypotension...
  5. doi Blast-induced brain injury and posttraumatic hypotension and hypoxemia
    Douglas S DeWitt
    Moody Center for Traumatic Brain and Spinal Cord Injury Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0830, USA
    J Neurotrauma 26:877-87. 2009
    ..Although secondary hypotension and hypoxemia are associated with increased mortality and morbidity after closed head injury, the effects of ..
  6. pmc The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers
    Alissa J Wright
    Department of Medicine, University of Toronto, Ont, Canada
    CMAJ 183:303-7. 2011
    ..We explored the risk of hypotension or shock requiring hospital admission following the simultaneous use of calcium-channel blockers and macrolide ..
  7. doi Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy
    Barbara Schreier
    Julius Bernstein Institute of Physiology, Medical Faculty, University of Halle Wittenberg, Halle, Germany
    Hypertension 61:333-40. 2013
    ....
  8. ncbi Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia
    T Sugaya
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan
    J Biol Chem 270:18719-22. 1995
    ..Previously, we showed chronic hypotension in angiotensinogen (the precursor of AT)-deficient mice and a dramatic increase in renin mRNA levels in its ..
  9. ncbi Incidence of intraoperative hypotension as a function of the chosen definition: literature definitions applied to a retrospective cohort using automated data collection
    Jilles B Bijker
    Department of Perioperative Care and Emergency Medicine, University Medical Center Utrecht, The Netherlands
    Anesthesiology 107:213-20. 2007
    Intraoperative hypotension (IOH) is a common side effect of general anesthesia and has been reported to be associated with adverse perioperative outcomes. These associations were found using different definitions for IOH...
  10. doi The main determinant of hypotension in nitroglycerine tilt-induced vasovagal syncope
    Gerardo Nigro
    Chair of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy
    Pacing Clin Electrophysiol 35:739-48. 2012
    ..The aim of the study was to assess the main determinant of the fall in blood pressure (BP) responsible for the head-up tilt testing-induced syncope...
  11. doi Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension
    Peter Nissen
    Department of Anesthesia, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Neurocrit Care 12:17-23. 2010
    Vasopressor agents are used to correct anesthesia-induced hypotension. We describe the effect of phenylephrine and ephedrine on frontal lobe oxygenation (S(c)O(2)) following anesthesia-induced hypotension.
  12. ncbi Angiotensin type 2 receptor mediates valsartan-induced hypotension in conscious rats
    H M Siragy
    Department of Medicine, University of Virginia Health System, Charlottesville 22908, USA
    Hypertension 35:1074-7. 2000
    ..The results suggest that increased angiotensin II, in response to sodium restriction and valsartan infusion, stimulates AT(2)R, which mediates a BK and NO cascade...
  13. doi The additive blood pressure lowering effects of exercise intensity on post-exercise hypotension
    John D Eicher
    University of Connecticut, Storrs, 06269 1110, USA
    Am Heart J 160:513-20. 2010
    ..We also examined clinical correlates of the BP response...
  14. ncbi Mechanisms and clinical implications of post-exercise hypotension in humans
    J R Halliwill
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Exerc Sport Sci Rev 29:65-70. 2001
    Post-exercise hypotension is common after moderate-intensity dynamic exercise. It results from persistent reductions in vascular resistance mediated by the autonomic nervous system and vasodilator substances...
  15. doi Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada
    Intensive Care Med 35:871-81. 2009
    To describe the incidence and outcomes associated with early acute kidney injury (AKI) in septic shock and explore the association between duration from hypotension onset to effective antimicrobial therapy and AKI.
  16. ncbi Potential causes, mechanisms, and implications of post exercise hypotension
    J R MacDonald
    Department of Medicine and Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Hum Hypertens 16:225-36. 2002
    Post exercise hypotension (PEH) is a phenomenon of a prolonged decrease in resting blood pressure in the minutes and hours following acute exercise...
  17. ncbi Effect of systemic nitric oxide synthase inhibition on postexercise hypotension in humans
    J R Halliwill
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 89:1830-6. 2000
    ..Phentolamine was given first to isolate the contribution of nitric oxide to postexercise hypotension by preventing reflex changes in sympathetic tone that result from systemic nitric oxide synthase inhibition and ..
  18. ncbi Treated hypotension is associated with neonatal morbidity and hearing loss in extremely low birth weight infants
    Jonathan M Fanaroff
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio, USA
    Pediatrics 117:1131-5. 2006
    Neonatal hypotension may be a risk factor for neurologic impairment. Few studies have examined the impact of low blood pressure in extremely low birth weight (ELBW) infants weighing 400 to 999 g on neurodevelopmental outcome.
  19. ncbi A systematic review of the clinical effects of reducing dialysate fluid temperature
    Nicholas M Selby
    Department of Renal Medicine, Derby City Hospital, Uttoxeter Road, Derby, DE22 3NE, UK
    Nephrol Dial Transplant 21:1883-98. 2006
    Intradialytic hypotension (IDH) is a frequent complication of haemodialysis. Reducing the temperature of the dialysis fluid is a simple therapeutic strategy but is relatively underused...
  20. doi Intraoperative hypotension and 1-year mortality after noncardiac surgery
    Jilles B Bijker
    Division of Perioperative Care and Emergency Medicine, Department of Anesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Anesthesiology 111:1217-26. 2009
    Intraoperative hypotension (IOH) is frequently associated with adverse outcome such as 1-yr mortality. However, there is no consensus on the correct definition of IOH...
  21. ncbi Hypotension and cognitive impairment: Selective association in patients with heart failure
    G Zuccala
    Department of Gerontology, Catholic University, Rome, Italy
    Neurology 57:1986-92. 2001
    Arterial hypotension has been associated with increased risk of dementia in some large prospective studies; and cognitive impairment is common among elderly with left ventricular function...
  22. ncbi Blood volume controlled hemodialysis in hypotension-prone patients: a randomized, multicenter controlled trial
    Antonio Santoro
    Divisione de Nefrologia e Dialisi Malpighi, Policlinico S Orsola Malpighi, Via P Palagi 9, 40138 Bologna, Italy
    Kidney Int 62:1034-45. 2002
    ..This multicenter, prospective, randomized, crossover study aimed to clarify whether BVT (treatment B) can improve hypotension-prone patients' treatment tolerance, compared with conventional hemodialysis (treatment A).
  23. ncbi Biofeedback regulation of ultrafiltration and dialysate conductivity for the prevention of hypotension during hemodialysis
    Violaine Begin
    Service de Nephrologie, Hĵpital du Sacré Coeur de Montreal, Universite de Montreal, Quebec, Canada
    ASAIO J 48:312-5. 2002
    Intradialytic hypotension remains a frequent complication of dialysis, occurring in up to 33% of patients...
  24. ncbi Prevention of hypotension after spinal anesthesia for cesarean section: 6% hydroxyethyl starch 130/0.4 (Voluven) versus lactated Ringer's solution
    Samia Madi-Jebara
    Department of Anesthesiology and Intensive Care, CHU Hôtel Dieu de France Hospital, Beirut, Lebanon
    J Med Liban 56:203-7. 2008
    The aim of this study is to compare the efficacy of HES 130/0.4, a new hydroxyethyl starch, to lactated Ringer's solution (LR) in the prevention of hypotension after spinal anesthesia for cesarean section (CS).
  25. doi Recent advances in the prevention and management of intradialytic hypotension
    Biff F Palmer
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Am Soc Nephrol 19:8-11. 2008
    Intradialytic hypotension continues to play a significant role in the morbidity and in some cases the mortality associated with maintenance hemodialysis...
  26. doi Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats
    Mofei Wang
    Department of Physiology II, Kanazawa Medical University, Uchinada, Japan and
    Am J Physiol Regul Integr Comp Physiol 305:R900-7. 2013
    ..and it is accompanied by hepatic venoconstriction in animals, which, in part, accounts for anaphylactic hypotension. Roles of norepinephrine and α-adrenoceptor in anaphylaxis-induced hypotension and portal hypertension were ..
  27. ncbi Pathophysiology of dialysis hypotension: an update
    J T Daugirdas
    University of Illinois at Chicago, VA Chicago Hospital West Side, Chicago, IL 60612, USA
    Am J Kidney Dis 38:S11-7. 2001
    Dialysis hypotension occurs because a large volume of blood water and solutes are removed over a short period of time, overwhelming normal compensatory mechanisms, including plasma refilling and reduction of venous capacity, due to ..
  28. ncbi The age-dependent relation of blood pressure to cognitive function and dementia
    Chengxuan Qiu
    Aging Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and Stockholm Gerontology Research Centre, Stockholm, Sweden
    Lancet Neurol 4:487-99. 2005
    ....
  29. ncbi Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis
    Mohammed A Qadeer
    Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Gastroenterol Hepatol 3:1049-56. 2005
    ..Because an adequately powered trial comparing risk of propofol with traditional agents is lacking, we performed a meta-analysis of the current literature...
  30. doi The anti-inflammatory agent N-acetyl cysteine exacerbates endotoxin-induced hypoxemia and hypotension and induces polycythemia in the ovine fetus
    Megan E Probyn
    School of Biomedical Sciences, Monash University, Clayton, Vic, Australia
    Neonatology 98:118-27. 2010
    ....
  31. pmc Alpha-adrenergic vascular responsiveness during postexercise hypotension in humans
    John R Halliwill
    Department of Exercise and Movement Science, University of Oregon, Eugene, OR 97403 1240, USA
    J Physiol 550:279-86. 2003
    In sedentary individuals, postexercise hypotension following a single bout of aerobic exercise is due to an unexplained peripheral vasodilatation...
  32. doi Early postnatal hypotension and developmental delay at 24 months of age among extremely low gestational age newborns
    J Wells Logan
    New Hanover Regional Medical Center, Wilmington, North Carolina, USA
    Arch Dis Child Fetal Neonatal Ed 96:F321-8. 2011
    To evaluate in extremely low gestational age newborns, relationships between indicators of hypotension during the first 24 postnatal hours and developmental delay at 24 months of age.
  33. ncbi The influence of recovery posture on post-exercise hypotension in normotensive men
    N M Raine
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, L3 2ET, Merseyside, United Kingdom
    Med Sci Sports Exerc 33:404-12. 2001
    PURPOSE: Postexercise hypotension may be the result of an impaired vasoconstrictor response...
  34. ncbi 3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats
    Asok R Karuri
    W Harry Feinstone Center for Genomic Research, University of Memphis, TN 38152, USA
    J Pharmacol Exp Ther 317:61-7. 2006
    ..Systemic production of nitric oxide (NO) by inducible nitric-oxide synthase (iNOS) is a major cause of hypotension and poor organ perfusion seen in septic shock...
  35. pmc Postexercise hypotension: central mechanisms
    Chao Yin Chen
    Department of Pharmacology, University of California, Davis, CA 95616, USA
    Exerc Sport Sci Rev 38:122-7. 2010
    ..exercise can lead to a postexercise decrease in blood pressure in hypertensive individuals, called postexercise hypotension. Compelling evidence suggests that the central baroreflex pathway plays a crucial role in the development of ..
  36. ncbi Hemodynamic and autonomic correlates of postexercise hypotension in patients with mild hypertension
    Jacopo M Legramante
    Dipartimento di Medicina Interna, Centro di Riabilitazione Cardiologica San Raffaele and Università di Roma Tor Vergata, 00173 Rome, Italy
    Am J Physiol Regul Integr Comp Physiol 282:R1037-43. 2002
    We investigated the interplay of neural and hemodynamic mechanisms in postexercise hypotension (PEH) in hypertension...
  37. doi Cerebrovascular regulation during transient hypotension and hypertension in humans
    Yu Chieh Tzeng
    Cardiovascular Systems Laboratory, Physiological Rhythms Unit, Department of Surgery and Anesthesia, University of Otago, Wellington, Wellington South, New Zealand
    Hypertension 56:268-73. 2010
    ..In this study we applied a pharmacological approach to evaluate dCA gain to transient hypotension and hypertension and compared this method with 2 established indices of dCA that do not explicitly ..
  38. doi Predictors of the complication of postintubation hypotension during emergency airway management
    Alan C Heffner
    Division of Critical Care Medicine, Department of Internal Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Crit Care 27:587-93. 2012
    Arterial hypotension is a recognized complication of emergency intubation that is independently associated with increased morbidity and mortality...
  39. ncbi Human serum albumin induced hypotension in the postoperative phase of cardiac surgery
    G Howard
    Department of Intensive Care Medicine, Christchurch Hospital, New Zealand
    Anaesth Intensive Care 29:591-4. 2001
    b>Hypotension associated with the rapid infusion of human serum albumin products was first recognised in Australasia in the early 1970s...
  40. doi Blood pressure, anti-hypotensive therapy, and neurodevelopment in extremely preterm infants
    Beau Batton
    Rainbow Babies and Children s Hospital, Department of Neonatology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    J Pediatr 154:351-7, 357.e1. 2009
    ..To compare neurodevelopment (ND) in 3 cohorts of extremely preterm infants: untreated with normal blood pressure (BP), untreated with low BP, and treated with low BP...
  41. doi Direct hemoperfusion with polymyxin-B-immobilized fiber columns improves septic hypotension and reduces inflammatory mediators in septic patients with colorectal perforation
    Tomoharu Shimizu
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan
    Langenbecks Arch Surg 394:303-11. 2009
    ....
  42. ncbi Fat embolism and acute hypotension during vertebroplasty: an experimental study in sheep
    Nikolaus Aebli
    Departments of Orthopaedic Surgery and Physiology, University of Otago, and the Department of Cardiology, Dunedin Hospital, Dunedin, New Zealand
    Spine (Phila Pa 1976) 27:460-6. 2002
    ..An experimental study of cardiovascular complications that arise during vertebroplasty was conducted...
  43. pmc Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock
    Anje Cauwels
    Department for Molecular Biomedical Research, VIB, Technologiepark 927, 9052 Ghent, Belgium
    J Mol Med (Berl) 88:921-30. 2010
    Septic shock is associated with life-threatening vasodilation and hypotension. To cause vasodilation, vascular endothelium may release nitric oxide (NO), prostacyclin (PGI2), and the elusive endothelium-derived hyperpolarizing factor (..
  44. doi Hypotension unawareness in profound orthostatic hypotension
    Steven D Arbogast
    Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Med 122:574-80. 2009
    Clinicians depend on history given by the patients when considering the diagnosis of orthostatic hypotension.
  45. doi Unexplained hypotension: the spectrum of dynamic left ventricular outflow tract obstruction in critical care settings
    Anand Chockalingam
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO, USA
    Crit Care Med 37:729-34. 2009
    ..To illustrate the clinical and hemodynamic abnormalities caused by dynamic left ventricular outflow tract obstruction (LVOTO) in critical care setting...
  46. doi Derivation and validation of a score based on Hypotension, Oxygen saturation, low Temperature, ECG changes and Loss of independence (HOTEL) that predicts early mortality between 15 min and 24 h after admission to an acute medical unit
    John Kellett
    Nenagh Hospital, Nenagh, County Tipperary, Ireland
    Resuscitation 78:52-8. 2008
    ..Predictive scores such as APACHE II have been used to assess patients in intensive care units, but few scores have been used to assess acutely ill general medical patients...
  47. doi Association between postexercise hypotension and long-term training-induced blood pressure reduction: a pilot study
    Anne Hecksteden
    Institute of Sports and Preventive Medicine, University of Saarland, Saarbruecken, Germany
    Clin J Sport Med 23:58-63. 2013
    ..The main hypothesis of the present study was an association between postexercise hypotension after an exhaustive exercise test and chronic blood pressure reductions in response to an endurance training ..
  48. ncbi The effect of frequent or occasional dialysis-associated hypotension on survival of patients on maintenance haemodialysis
    Andras Tisler
    First Department of Medicine, Faculty of Medicine, Semmelweis University, 2 a Koranyi S, H 1083 Budapest, Hungary
    Nephrol Dial Transplant 18:2601-5. 2003
    While frequent or occasional symptomatic intradialytic hypotension (IDH) may influence patient well-being, its effects on survival-independent of comorbidities-has not previously been investigated...
  49. ncbi Neurally mediated hypotension and autonomic dysfunction measured by heart rate variability during head-up tilt testing in children with chronic fatigue syndrome
    J Stewart
    Department of Pediatrics, New York Medical College, Valhalla 10595, USA
    Clin Auton Res 8:221-30. 1998
    Recent investigations suggest a role for neurally mediated hypotension (NMH) in the symptomatology of chronic fatigue syndrome (CFS) in adults...
  50. ncbi CBF reactivity in hypotensive and normotensive preterm infants
    Dulip Jayasinghe
    Division of Paediatrics and Child Health, Clarendon Wing, The General Infirmary at Leeds, Leeds LS2 9NS, United Kingdom
    Pediatr Res 54:848-53. 2003
    ..A component of this distress is thought to be hypotension. We examined the autoregulatory capacity of hypotensive and normotensive infants using the 133Xe technique to ..
  51. pmc Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome
    Shih Hua Lin
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
    Proc Natl Acad Sci U S A 108:17538-43. 2011
    ..In the kidneys, NKCC2 but not NCC is the main target of OSR1 and the reduced p-NKCC2 in KSP-OSR1(-/-) mice may lead to a Bartter-like syndrome...
  52. ncbi Multiple effects of hyperbaric oxygen on the expression of HIF-1 alpha and apoptotic genes in a global ischemia-hypotension rat model
    Yun Li
    Department of Neurosurgery, Louisiana State University Health Science Center, Shreveport, LA, USA
    Exp Neurol 191:198-210. 2005
    ..Male SD rats (n = 78) were randomly divided into 13 groups: 1 sham group, 6 groups of global ischemia-hypotension (GI), and 6 groups of HBO treatment after global ischemia-hypotension (GI + HBO)...
  53. pmc Duration and magnitude of hypotension and monocyte deactivation in patients with community-acquired pneumonia
    Peter M Simon
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Shock 36:553-9. 2011
    The objective was to examine the relationship of duration and magnitude of arterial hypotension to subsequent cellular immune suppression and cytokinemia in patients hospitalized with community-acquired pneumonia (CAP)...
  54. doi Dopamine therapy promotes cerebral flow-metabolism coupling in preterm infants
    Flora Y Wong
    Ritchie Centre for Baby Health Research, Monash University, Level 5, Monash Medical Centre, 246 Clayton Road, Clayton, Vic, 3168, Australia
    Intensive Care Med 35:1777-82. 2009
    ..We contrasted the relationship between cerebral perfusion and oxygen metabolism in preterm infants treated with dopamine because of hypotension with normotensive controls.
  55. doi Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience
    Massimo Agostoni
    Department of Anesthesiology, Vita Salute University of Milan, IRCCS H San Raffaele, Milan, Italy
    Gastrointest Endosc 74:266-75. 2011
    ..The importance of sedation during endoscopy is well established. There is no consensus about the best techniques for sedation, which specialist should perform it, and in which location...
  56. ncbi Nonlinear relations of blood pressure to cognitive function: the Baltimore Longitudinal Study of Aging
    Shari R Waldstein
    Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Cir, Baltimore, MD 21250, USA
    Hypertension 45:374-9. 2005
    ..Careful monitoring and treatment of both high and low BP levels may be critical to the preservation of cognitive function...
  57. pmc Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Shock 36:104-8. 2011
    ..of this analysis was to compare patterns of biomarkers of endothelial cell activation in patients with hypotension due to sepsis and nonsepsis etiologies...
  58. doi Evaluation of MP4OX for prevention of perioperative hypotension in patients undergoing primary hip arthroplasty with spinal anesthesia: a randomized, double-blind, multicenter study
    Christina I Olofsson
    Department of Anesthesia and Intensive Care, Karolinska Institutet and Karolinska University Hospital, Solna, Stockholm, Sweden
    Anesthesiology 114:1048-63. 2011
    ..The primary goal of this study was to investigate MP4OX for preventing hypotensive episodes. An additional goal was to establish the safety profile of MP4OX in a large surgical population...
  59. ncbi Case records of the Massachusetts General Hospital. Case 24-2006. A 40-year-old woman with hypotension after an overdose of amlodipine
    N Stuart Harris
    Department of Emergency Medicine, Massachusetts General Hospital, and Harvard Medical School, USA
    N Engl J Med 355:602-11. 2006
  60. ncbi Nonlinear analysis of blood cell flux fluctuations in the rat brain cortex during stepwise hypotension challenge
    Peter Herman
    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    J Cereb Blood Flow Metab 26:1189-97. 2006
    ..29+/-0.006 and 0.25+/-0.012, respectively) were independent of BP. Neither D(corr) nor lambda(max) varied with hypotension. Their values were characteristic of a chaotic system, but surrogate data analysis rendered some of them ..
  61. ncbi Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats
    R M Carey
    Department of Medicine, University of Virginia Health System, Charlottesville 22908, USA
    Hypertension 38:1272-7. 2001
    ..The results strongly suggest that the AT(2) receptor induces a systemic vasodilator response mediated by NO that counterbalances the vasoconstrictor action of Ang II at the AT(1) receptor...
  62. doi Focused cardiac ultrasound in the emergent setting: a consensus statement of the American Society of Echocardiography and American College of Emergency Physicians
    Arthur J Labovitz
    St Louis University School of Medicine, St Louis, Missouri, USA
    J Am Soc Echocardiogr 23:1225-30. 2010
    ..In the emergency department, focused cardiac ultrasound has become a fundamental tool to expedite the diagnostic evaluation of the patient at the bedside and to initiate emergent treatment and triage decisions by the emergency physician...
  63. ncbi Prospective, multicenter evaluation of risk factors associated with invasive bacterial infection in children with cancer, neutropenia, and fever
    M E Santolaya
    Department of Pediatrics, Hospital Luis Calvo Mackenna, Chile
    J Clin Oncol 19:3415-21. 2001
    ..To identify clinical and laboratory parameters present at the time of a first evaluation that could help predict which children with cancer, fever, and neutropenia were at high risk or low risk for an invasive bacterial infection...
  64. ncbi Intraoperative hypotension and prolonged operative time as risk factors for slow graft function in kidney transplant recipients
    Mohamad S Sandid
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Transplant 20:762-8. 2006
    ..The objective of this study was to test whether intraoperative hypotension and/or prolonged operative time are risk factors for SGF in patients post-cadaveric kidney transplant.
  65. ncbi Controversies in the diagnosis and management of hypotension in the newborn infant
    I Seri
    The Children s Hospital of Philadelphia, The University of Pennsylvania, Department of Pediatrics, Division of Neonatology, Philadelphia, Pennsylvania, USA
    Curr Opin Pediatr 13:116-23. 2001
    Although close to half of the newborns admitted to neonatal intensive care units receive treatment for "hypotension," the normal physiologic blood pressure range ensuring appropriate organ perfusion in the neonate is unknown...
  66. ncbi Dose requirement and complications of diluted and undiluted propofol for deep sedation in endoscopic retrograde cholangiopancreatography
    Somchai Amornyotin
    Department of Anesthesiology and Siriraj GI Endoscopy Center, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Hepatobiliary Pancreat Dis Int 10:313-8. 2011
    ..The aim of this study was to determine the dose requirement and complications of diluted and undiluted propofol for deep sedation in endoscopic retrograde cholangiopancreatography...
  67. doi Hypotension during fluid-restricted abdominal surgery: effects of norepinephrine treatment on regional and microcirculatory blood flow in the intestinal tract
    Luzius B Hiltebrand
    Department of Anesthesiology and Pain Therapy, Regional Hospital Emmental and University of Bern, Bern, Switzerland
    Anesthesiology 114:557-64. 2011
    Vasopressors, such as norepinephrine, are frequently used to treat perioperative hypotension. Increasing perfusion pressure with norepinephrine may increase blood flow in regions at risk...
  68. doi Early systemic hypotension and vasopressor support in low birth weight infants: impact on neurodevelopment
    Adelina Pellicer
    La Paz University Hospital, Department of Neonatology, Paseo de Castellana 261, E 28046 Madrid, Spain
    Pediatrics 123:1369-76. 2009
    The duration and severity of systemic hypotension have been related with altered neurodevelopment. Cerebral circulation is pressure-passive in low birth weight infants with early systemic hypotension who receive cardiovascular support...
  69. pmc Prenatal dexamethasone 'programmes' hypotension, but stress-induced hypertension in adult offspring
    David O'Regan
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Endocrinol 196:343-52. 2008
    ..We therefore conclude that altered sympathetic responses mediate the stress-induced hypertension associated with prenatal DEX programming...
  70. ncbi Predilution haemofiltration--the Second Sardinian Multicentre Study: comparisons between haemofiltration and haemodialysis during identical Kt/V and session times in a long-term cross-over study
    P Altieri
    Divisione Nefrologia e Dialisi Ospedale San Michele, Cagliari, Italy
    Nephrol Dial Transplant 16:1207-13. 2001
    ..The frequency of intra-treatment episodes of hypotension/patient/month was significantly lower on HF1 (1.24) and HF2 (1.27) than on HD (1.80) (P<0.04)...
  71. pmc Factors associated with treatment for hypotension in extremely low gestational age newborns during the first postnatal week
    Matthew Laughon
    School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Pediatrics 119:273-80. 2007
    ....
  72. ncbi The incidence and risk factors for hypotension after spinal anesthesia induction: an analysis with automated data collection
    Bernd Hartmann
    Department of Anesthesiology and Intensive Care Medicine, Justus Liebig University Giessen, Rudolf Buchheim Strasse 7, D 35392 Giessen, Germany
    Anesth Analg 94:1521-9, table of contents. 2002
    We sought to identify factors that are associated with hypotension after the induction of spinal anesthesia (SpA) by using an anesthesia information management system...
  73. pmc Activation of estrogen receptor beta-dependent nitric oxide signaling mediates the hypotensive effects of estrogen in the rostral ventrolateral medulla of anesthetized rats
    Cheng Dean Shih
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 90741, Taiwan, Republic of China
    J Biomed Sci 16:60. 2009
    ....
  74. pmc Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits
    Atsunori Kamiya
    Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute, Osaka 565 8565, Japan
    J Physiol 566:237-46. 2005
    ..activity (SNA) to a higher SNA, and (2) resetting of the arterial baroreflex contributes to preventing postural hypotension. Renal SNA and AP were recorded in eight anaesthetized, vagotomized and aortic-denervated rabbits...
  75. ncbi Hypotension, bradycardia and syncope caused by honey poisoning
    Ozcan Yilmaz
    Ondokuz Mayis University School of Medicine, Department of Cardiology, Kurupelit, Samsun, Turkey
    Resuscitation 68:405-8. 2006
    ..were hospitalized with a variety of symptoms including nausea, vomiting, salivation, dizziness, weakness, hypotension, bradycardia and syncope several hours after the ingestion of small amounts of honey...
  76. pmc Crisis management during anaesthesia: hypotension
    R W Morris
    Sydney Medical Simulation Centre, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Qual Saf Health Care 14:e11. 2005
    b>Hypotension is commonly encountered in association with anaesthesia and surgery. Uncorrected and sustained it puts the brain, heart, kidneys, and the fetus in pregnancy at risk of permanent or even fatal damage...
  77. ncbi Regional hemodynamics during postexercise hypotension. I. Splanchnic and renal circulations
    Mollie P Pricher
    Department of Human Physiology, University of Oregon, Eugene, OR 97403 1240, USA
    J Appl Physiol 97:2065-70. 2004
    Moderate exercise elicits a relative postexercise hypotension that is caused by an increase in systemic vascular conductance. Previous studies have shown that skeletal muscle vascular conductance is increased postexercise...
  78. doi A double-blind, randomized, multicenter study of MP4OX for treatment of perioperative hypotension in patients undergoing primary hip arthroplasty under spinal anesthesia
    Philippe Van der Linden
    Department of Anesthesiology, CHU Brugmann, Brussels, Belgium
    Anesth Analg 112:759-73. 2011
    ..In this study, we investigated the ability of MP4OX to treat hypotensive episodes. In addition, the tolerability profile of MP4OX in a large surgical population was established...
  79. ncbi Post exercise hypotension is sustained during subsequent bouts of mild exercise and simulated activities of daily living
    J R MacDonald
    Department of Kinesiology, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    J Hum Hypertens 15:567-71. 2001
    ..suppression of blood pressure that occurs during the hours following acute exercise (termed post exercise hypotension) persists throughout an active period of subsequent mild exercise and simulated activities of daily living (ADL)..
  80. ncbi Systemic hypotension and the development of acute sensorineural hearing loss in young healthy subjects
    A Pirodda
    Ear, Nose and Throat Section, Department of Surgical and Anaesthesiological Sciences, S Orsola Hospital, University of Bologna, Bologna, Italy
    Arch Otolaryngol Head Neck Surg 127:1049-52. 2001
    ..Sudden sensorineural hearing loss (SSHL) is an acute disorder whose origin is often unclear. A vascular disorder may be a causative factor...
  81. ncbi Hypotension begins at 110 mm Hg: redefining "hypotension" with data
    Brian J Eastridge
    U S Army Institute for Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 63:291-7; discussion 297-9. 2007
    Clinicians routinely refer to hypotension as a systolic blood pressure (SBP) < or =90 mm Hg. However, few data exist to support the rigid adherence to this arbitrary cutoff...
  82. doi The effects of muscle mass and number of sets during resistance exercise on postexercise hypotension
    Marcos D Polito
    Physical Education Department, Universidade Estadual de Londrina, Londrina, Parana, Brazil
    J Strength Cond Res 23:2351-7. 2009
    The effects of muscle mass and number of sets on postexercise hypotension (PEH) following resistance exercises are barely known...
  83. doi Vasoactive drugs and acute kidney injury
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Hospital, Melbourne, Australia
    Crit Care Med 36:S179-86. 2008
    ..Whether it is superior to noradrenaline in this setting remains uncertain, and more studies are needed before recommendations can be made...
  84. pmc CB(1) cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction
    Jens A Wagner
    Department of Medicine and Cardiology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Br J Pharmacol 138:1251-8. 2003
    ..that during the development of congestive heart failure post-large MI, cannabinoid treatment increases LVEDP and prevents hypotension and ED. Presumed CB(1) antagonism promotes remodeling despite unchanged myocardial CB(1) expression.
  85. doi Prehospital hypotension redefined
    Brandon Bruns
    Department of Surgery, Division of Burns, Trauma, and Critical Care, University of Texas Southwestern Medical School, Parkland Memorial Hospital, Dallas, Texas, USA
    J Trauma 65:1217-21. 2008
    ..However, Advanced Trauma Life Support recognizes this threshold as a late sign of shock. We undertook the current study to determine whether a higher PSBP threshold may identify patients at significant risk of death...
  86. pmc Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice
    Tammie Bishop
    The Henry Wellcome Building for Molecular Physiology, University of Oxford, Headington Campus, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Mol Cell Biol 28:3386-400. 2008
    ..Perturbation of this interface between developmental and adaptive signaling by hypoxic, metabolic, or other stresses could have important effects on key sympathoadrenal functions, such as blood pressure regulation...
  87. doi Human umbilical cord blood cells protect against hypothalamic apoptosis and systemic inflammation response during heatstroke in rats
    Won Shiung Liu
    Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan
    Pediatr neonatol 50:208-16. 2009
    ..of human umbilical cord blood cells (HUCBC) has been shown to improve heatstroke by reducing arterial hypotension as well as cerebral ischemia and damage in a rat model...
  88. ncbi Hypotensive extremely low birth weight infants have reduced cerebral blood flow
    Michael J Munro
    Ritchie Centre for Baby Health Research, Monash Institute of Reproduction and Development, Monash University and Newborn Services, Monash Medical Centre, Victoria, Australia
    Pediatrics 114:1591-6. 2004
    ..We addressed these issues in ELBW infants undergoing intensive care...
  89. doi Chronic angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy combined with diuretic therapy is associated with increased episodes of hypotension in noncardiac surgery
    Sachin Kheterpal
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA
    J Cardiothorac Vasc Anesth 22:180-6. 2008
    ..inhibitor (ACE-I) or angiotensin receptor blocker (ARB) therapy has been reported to result in intraoperative hypotension in patients undergoing general anesthesia...
  90. ncbi Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study
    Andrea Riphaus
    Department of Internal Medicine I Gastroenterology and Interventional Endoscopy, Klinikum Hannover Siloah, Teaching Hospital of the Hannover Medical School, Hannover, Germany
    Am J Gastroenterol 100:1957-63. 2005
    ....
  91. ncbi Prophylactic ephedrine prevents hypotension during spinal anesthesia for Cesarean delivery but does not improve neonatal outcome: a quantitative systematic review
    Anna Lee
    Department of Anaesthesia, Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Can J Anaesth 49:588-99. 2002
    The objective of this systematic review was to assess the effectiveness and safety of ephedrine compared with control when given prophylactically to prevent hypotension during spinal anesthesia for Cesarean delivery.
  92. ncbi Hypotension, hypoxia, and head injury: frequency, duration, and consequences
    G Manley
    Department of Surgery, San Francisco General Hospital, Ward 3A, 1001 Potrero Ave, San Francisco, CA 94110, USA
    Arch Surg 136:1118-23. 2001
    BACKGROUND: Retrospective studies have suggested an association between systemic hypotension and hypoxia and worsened outcome from traumatic brain injury...
  93. ncbi Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release
    T Kishi
    Department of Cardiovascular Medicine, Cardiovascular Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertension 38:896-901. 2001
    ..Furthermore, these responses may be mediated by an increased release of GABA in the RVLM...
  94. ncbi Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006
    Massimo Antonelli
    Istituto di Anestesiologia e Rianimazione, Policlinico Universitario A Gemelli, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8, 00168 Rome, Italy
    Intensive Care Med 33:575-90. 2007
    ..The goal of this consensus statement is to provide recommendations regarding the monitoring and management of the critically ill patient with shock...
  95. ncbi Post-resistance exercise hypotension, hemodynamics, and heart rate variability: influence of exercise intensity
    C C Rezk
    Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Av Prof Mello de Moraes, 65, Butanta, Sao Paulo, SP, Brazil
    Eur J Appl Physiol 98:105-12. 2006
    The occurrence of post-exercise hypotension after resistance exercise is controversial, and its mechanisms are unknown...
  96. ncbi Cardiovascular support for low birth weight infants and cerebral hemodynamics: a randomized, blinded, clinical trial
    Adelina Pellicer
    Department of Neonatology, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain
    Pediatrics 115:1501-12. 2005
    ..Maintaining adequate organ blood flow is the target of vasopressor treatment, but the impact of these measures on cerebral perfusion has not yet been evaluated systematically in a randomized, blinded, clinical trial...
  97. ncbi Sodium ramping reduces hypotension and symptoms during haemodialysis
    H L Tang
    Division of Nephrology, Department of Medicine and Geriatrics, Princess Margaret Hospital, Laichikok, Hong Kong
    Hong Kong Med J 12:10-4. 2006
    ..To evaluate the effectiveness of sodium ramping (profiling) in reducing hypotensive episodes and symptoms during haemodialysis...
  98. ncbi Profound hypotension and associated electrocardiographic changes during prolonged cord occlusion in the near term fetal sheep
    Bert Wibbens
    Department of Physiology and Obstetrics and Gynecology, University of Auckland, Auckland, New Zealand
    Am J Obstet Gynecol 193:803-10. 2005
    To determine whether the onset of fetal hypotension during profound asphyxia is reflected by alterations in the ratio between the T height, measured from the level of the PQ interval, and the QRS amplitude (T/QRS ratio) and ST waveform.
  99. ncbi A brief episode of hypotension increases mortality in critically ill trauma patients
    Mazen S Zenati
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 53:232-6; discussion 236-7. 2002
    b>Hypotension is associated with increased mortality, however previous studies have failed to account for the depth and duration of hypotension. We evaluated the effect of the duration of hypotension on outcome in injured patients.
  100. doi Depressive symptoms in elderly adults with hypotension: different associations with positive and negative affect
    Byung Soo Kim
    Mental Health Clinic, National Cancer Center, Goyang si, Republic of Korea
    J Affect Disord 127:359-64. 2010
    The association of hypotension with depression in the elderly is controversial...
  101. ncbi Effect of acetate, bicarbonate dialysis, and acetate-free biofiltration on nitric oxide synthesis: implications for dialysis hypotension
    M Noris
    Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Am J Kidney Dis 32:115-24. 1998
    ..BD), and acetate-free biofiltration (AFB) on nitric oxide (NO) synthesis and the implications for dialysis hypotension was studied...

Research Grants70

  1. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..percent (82%) of apoptotic cells within the lung were AECs;AEC apoptosis increased with increasing duration of hypotension and required resuscitation...
  2. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..play a major role in the activation of the hypothalamo-pituitary axis during stresses such as infection, hypotension, pain and hypoxia and they also contribute to the regulation of glucose metabolism...
  3. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..K+-ATP channel opener, providing profound cytoprotection without induction of hyperglycemia and diastolic hypotension. The addition of the redox catalytic function provides R-801 with the capacity to neutralize not only reactive ..
  4. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..Loss-of-function mutations in human NCC and NKCC2 result in hypotension due to renal sodium wasting, and these transporters are the targets of thiazide and loop diuretics, ..
  5. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..of the classic side-effects of sarcolemmal K+-ATP channel activation (hyperglycemia, ventricular fibrillation, hypotension)...
  6. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..pressure regulator (ITPR), intended to increase circulation and blood pressure clinically significant states of hypotension, including cardiac arrest and septic shock...
  7. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..However, both hypertension and hypotension are poorly treated because many patients often are unwilling to use standard medical therapy...
  8. Neuropeptide regulation of neurohypophyseal function
    Francis W Flynn; Fiscal Year: 2012
    ..because pretreatment with NK3R antagonists block both VP and OT release to both hyperosmolarity and hypovolemia/hypotension. Furthermore, NK3R play a traditional role in cellular signaling and immediate responses to hyperosmolarity and ..
  9. Citrulline to Prevent or Mitigate Acute Lung Injury in Severe Sepsis
    Todd W Rice; Fiscal Year: 2013
    ..oxidative stress and production of NO in patients;2) be safe and not exacerbate vasomotor instability and/or hypotension;and 3) improve clinical outcomes, including prevention of both the development and progression of ALI...
  10. Epithelial Sodium Channels in the Supraoptic Vasopressin and Oxytocin Neurons
    Ryoichi Teruyama; Fiscal Year: 2009
    ..The secretion of VP increases in response to hyperosmolality, hypovolemia, and hypotension, and produces antidiuretic and pressor effects (Sladek 2000)...
  11. Respiratory motor control and blood pressure regulation after spinal cord injury
    ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013
    ..SCI) face the challenge of managing their unstable blood pressure which frequently results in persistent hypotension due to decreased cardiac output and autonomic nervous system dysfunction...
  12. Characterization of the ER associated Biogenesis and Degradation of ENaC
    Teresa M Buck; Fiscal Year: 2013
    ..are associated with Liddle's Syndrome and pseudohypoaldosteronism type I that result in hyper- and hypotension respectively...
  13. Molecular Regulation of Ischemic Renal Failure
    Zheng Dong; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: VA RELEVANCE: A broad range of clinical conditions including dehydration, hypotension, septic shock, trauma and operative arterial clamping leads to the reduction of blood flow to the kidneys...
  14. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..to estimate the relative contribution of IMPACT variables (age, GCS motor score, pupillary reaction, hypoxia, hypotension, initial head CT classification, traumatic subarachnoid hemorrhage or epidural mass on CT, serum glucose, and ..
  15. Cardiac dysfunction in StrepTSS: interplay of SLO and MMPs
    Dennis L Stevens; Fiscal Year: 2013
    ..Marked hypotension and early multi-organ failure are distinctive features and recently evidence of severely impaired cardiac ..
  16. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..delayed onset of action, or lack of specificity for ischemic tissue causing the dose to be limited by systemic hypotension. A novel mechanism for selective vasodilation is allosterically- modulated delivery of hemoglobin borne nitric ..
  17. Epithelial Sodium Channels in Vasopressin and Oxytocin Synthesizing Magnocellular
    Ryoichi Teruyama; Fiscal Year: 2013
    ..The secretion of VP increases in response to hyperosmolality, hypovolemia, and hypotension, and produces antidiuretic and pressor effects (4)...
  18. Establishing a neuroprotection model in the nonhuman primate to support translati
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2013
    ..microvasculature of the optic disc, often in the setting of an anatomically susceptible disc and/or systemic hypotension, a cascade of events contributes to axonal injury and RCG endangerment, culminating in caspace-associated ..
  19. Development of the orally delivered, non-absorbable ACE inhibitor enalaprilat for
    ELKE LIPKA; Fiscal Year: 2010
    ..treatment shows tremendous potential in treating IBD, a major consequence of the ACE inhibition is systemic hypotension seen with most currently marketed oral ACE inhibitors...
  20. Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage
    JEFFREY RADIN KAISER; Fiscal Year: 2012
    ..Increasing hypercapnia has been associated with progressively impaired cerebral autoregulation. Hypotension may cause cerebral hypoperfusion, leading to IVH in infants with impaired cerebral autoregulation by an ..
  21. The Role of MKP-1 in innate immune responses to LPS
    Yusen Liu; Fiscal Year: 2010
    ..The mortality rate from severe sepsis ranges from 30-50%. Severe sepsis is often associated with profound hypotension, massive vasodilation, shock, and multiple organ failure...
  22. Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest
    Alexis A Topjian; Fiscal Year: 2013
    ..The primary measure of adverse outcome is the intensity and duration of hypotension. Finally, in Aim 3 we will evaluate if larger NCS burden during the first three days post-arrest is associated ..
  23. Detection and Quantification of Neonatal Intraventricular Hemorrhage
    Michael D Weiss; Fiscal Year: 2013
    ..g., loss of cerebral blood flow autoregulation, increased central venous pressure, hypotension) have been associated with IVHs through retrospective studies, but exact cause-effect relationships between ..
  24. Role of Serotonin in Smypathetic Function
    Karie E Scrogin; Fiscal Year: 2012
    ..central nervous system mechanisms that regulate autonomic and respiratory compensation following hypovolemic hypotension and circulatory shock...
  25. Central Endocannabinoid System Dysfunction and Hypertension
    Jeanne L Seagard; Fiscal Year: 2013
    ..of the baroreflex is underscored by the consequences of impaired baroreflex function - volatile BP, orthostatic hypotension, and occasionally malignant vagotonia...
  26. gC1q-R/P33: Structure-function and role in inflammation
    Berhane Ghebrehiwet; Fiscal Year: 2012
    ..of bradykinin, a potent vasoactive peptide involved in various inflammatory processes including angioedema, hypotension, angiogenesis, and blood cell trafficking...
  27. Thiamine as a Metabolic Resuscitator in Septic Shock
    Michael William Donnino; Fiscal Year: 2012
    ..Septic shock may be characterized by hypotension, high metabolic state, lactic acidosis and potentially death...
  28. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..In persons with tetraplegia arterial blood pressure is usually low (11), however the prevalence of hypotension (i.e., d 110/70 mmHg) was reported to be 16% among a large cohort of veterans with SCI (13)...
  29. Nitric oxide protects against microcirculatory complications of malaria
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2010
    ..Vascular leak, petechial hemorrhaging, and hypotension are well recognized complications of experimental cerebral malaria (ECM), and the proposed studies will ..
  30. Cellular and molecular mechanisms of preterm white matter injury
    Art Riddle; Fiscal Year: 2013
    ..establish better clinical care for critically ill preterm infants at risk for multiple episodes of ischemia and hypotension. To achieve these objectives an in utero preparation in the 0...
  31. Physiologic role of the gamma epithelial sodium channel subunit in the kidney
    Donald E Kohan; Fiscal Year: 2010
    ..mutations are associated with hypertension, whereas loss-of-function mutations are associated with hypotension. ENaCs are comprised of three structurally related subunits termed ?, ? and ?...
  32. Intrathecal therapy for autonomic dysreflexia
    Paul C Dolber; Fiscal Year: 2013
    ..visceral distension in rats four weeks after T4 spinal cord transection, as well as their effect on orthostatic hypotension. Specific aim 1 does so for acute intrathecal delivery of both nonselective and selective agonists to the T6 ..
  33. Eicosanoids and carbon monoxide in neonatal cerebral microcirculation
    ALIE JOSEPH KANU; Fiscal Year: 2012
    ..have shown that prostanoids generated in cerebral blood vessels contribute to cerebral vasodilation produced by hypotension. Recently, we reported that arachidonic acid (AA)-induced cerebrovasodilation is mediated by COX products, ..
  34. Leukocyte Trafficking in Acute Renal Failure
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..of a drug (or other drugs) that could potentially have adverse side effects such as platelet dysfunction, hypotension and systemic immunosuppression, serves as a proof of concept model that tolerized DCs (from any treatment ..
  35. Fe porphyrin-based Redox Modulator in Experimental Stroke Outcome
    Ines Batinic-Haberle; Fiscal Year: 2013
    ..Yet, the dose and the therapeutic efficacy of Mn porphyrin were limited due to an adverse effect of arterial hypotension. Its Fe analog, (OH)FeTnHex-2-PyP4+, was recently synthesized and fully characterized...
  36. Development of Novel Agents for CNS-related Diseases
    Seth Y Ablordeppey; Fiscal Year: 2012
    ..been found to produce a new set of adverse events including weight gain, obesity, type II diabetes, seizures, hypotension, hyperlipidemia and cardiovascular disease (CVD)...
  37. Monocyte P311 Expression Level as Predictor of Hypertension in Mice
    Lucia Schuger; Fiscal Year: 2010
    ..studies we recently found that p311-deficient mice (P311 KOs) have pronounced systemic systolic and diastolic hypotension, without overt gross or microscopic vascular abnormalities...
  38. Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging
    Farzaneh A Sorond; Fiscal Year: 2010
    ..linked to hypoxic-ischemic injury, such as cerebral microvascular disease, autonomic failure with orthostatic hypotension, stroke, dementia and congestive heart failure...
  39. Role of hemoglobin b93cys residue in nitric oxide bioactivity
    RAKESH PRAVINCHANDRA PATEL; Fiscal Year: 2013
    ..signaling in vivo, 3) Determine the role of the 293cys residue in affecting RBC effects during Sepsis induced hypotension and pulmonary inflammation...
  40. Etiology of microvascular changes in Gram-positive sepsis: mechanisms and therape
    Perenlei Enkhbaatar; Fiscal Year: 2013
    ..vasopressin V1a receptors (V1aR) will mitigate MRSA sepsis-induced vascular hyper-permeability and reverse the hypotension, whereas the stimulation of the arginine vasopressin V2 receptors (V2R) will augment the vascular hyper- ..
  41. Improving Outcomes in Cardiac Arrest/CPR with Inhaled Nitric Oxide
    Fumito Ichinose; Fiscal Year: 2013
    ..Because inhaled NO does not cause systemic hypotension, in contrast to systemic NO-donors, it is uniquely suited for the treatment of post-CA patients in whom blood ..
  42. Cell-targeted drug delivery for the treatment of pulmonary arterial hypertension
    Masahiko Oka; Fiscal Year: 2012
    ..For example, systemic hypotension is a serious limitation in the treatment of PAH patients with potent vasodilators...
  43. Androgens raise venous and arterial adrenergic tone.
    Douglas S Martin; Fiscal Year: 2010
    ..In addition, in patients hypertension is poorly controlled. Moreover, postural hypotension is common adverse effect of antihypertensive therapy, implying dysregulation of venous function...
  44. Prevention and Risk Identification of SUDEP Mortality - the PRISM Project
    Samden Lhatoo; Fiscal Year: 2013
    ..exaggerated supra-pontine seizure influences produce severe autonomic dysfunction manifested as profound hypotension, fatal arrhythmia or apnea. Genetic predisposition and brainstem serotonergic dysregulation may contribute...
  45. Effect of Thiamine on Pyruvate Dehydrogenase Activity in Septic Shock
    Michael William Donnino; Fiscal Year: 2013
    ..Septic shock is characterized by hypotension, high metabolic state, lactic acidosis and potentially death...
  46. Kidney Injury and Dysfunction Support (KIDS)
    Matthew Paden; Fiscal Year: 2010
    ..devices in children is plagued with safety and quality concerns such as inaccurate fluid balance leading to hypotension, excessive extracorporeal blood volumes leading to increased blood transfusion needs, and lack of compatibility ..
  47. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..upon recent animal studies showing that non-invasive IPR can increase vital organ perfusion in states of severe hypotension, the goal of this research is to demonstrate proof of concept in a porcine model of septic shock that when IPR ..
  48. Discovery of rare genomic variants affecting blood pressure phenotype in humans
    Murim Choi; Fiscal Year: 2012
    ..genetic screen studies discovered a number of genes that are associated with extreme forms of hypertension or hypotension disorders...
  49. Redesigning General Anesthesia
    Matthew A Wilson; Fiscal Year: 2013
    ..effects most likely explains a significant component of anesthesia-related morbidity;drug side effects (nausea, hypotension, respiratory depression, hypothermia) are due to actions at sites other than their intended targets whereas ..
  50. Climate Change and Cardiac Vulnerability in Humans
    Antonella Zanobetti; Fiscal Year: 2012
    ..the health implications for vulnerable populations of projected pollution and climate changes, for an increase (or reduction) in days when they are at high risk for hypertension, hypotension, malignant cardiac arrhythmias and stroke.
  51. Polynitroxylated Pegylated Hemoglobin for Traumatic Brian Injury Resuscitation
    CARLETON HSIA; Fiscal Year: 2013
    ..TBI) is a leading cause of morbidity and mortality especially when complicated by secondary insults such as hypotension. Vulnerability of TBI patients to hypotension is well recognized and identifies a key need for new approaches...
  52. Mechanisms of 5-hydroxytryptamine-induced hypotension
    ROBERT PATRICK DAVIS; Fiscal Year: 2013
    ..The mechanism underlying 5-HT-induced hypotension is not yet mown...
  53. Biochemical Markers of Traumatic Brain Injury
    STEVEN ANDREW ROBICSEK; Fiscal Year: 2010
    ..g. diffuse injury vs. mass lesion), occurrence of secondary insults (e.g. hypotension, elevated intracranial pressure) and outcome (e.g. neurological assessments and MRI)...
  54. Ambulatory BP, kidney function, cognitive &physical function in older adults
    DENA EVETTE RIFKIN; Fiscal Year: 2013
    ..pressure measurements, but data on associations of other abnormal ABPM patterns (pulse pressure variability, hypotension, and arterial stiffness indices) with kidney disease, cognitive, and physical dysfunction in contemporary ..
  55. CATECHOLAMINES AND SEROTONIN IN BLOOD PRESSURE CONTROL
    Curt Freed; Fiscal Year: 1991
    ..follow the time course of catechol and 5-HIAA concentrations continuously during drug- induced hypertension and hypotension. During the first award period of this grant, we found that the serotonin metabolite 5- HIAA was increased in ..
  56. Clinical Significance of protamine/heparin antibodies after CPB
    Gowthami M Arepally; Fiscal Year: 2012
    ..Complications of PRT in CPB range from mild symptoms (hypotension) to rare life-threatening side-effects (acute pulmonary hypertension and/or anaphylaxis)...
  57. Alcohol intoxication &Shock;specific needs &targeted resuscitation strategies
    Jesse Sulzer; Fiscal Year: 2012
    ..response to hemorrhagic shock (HS) during acute alcohol intoxication (AAI), as evidenced by greater hypotension in response to blood loss, impaired blood pressure recovery during fluid resuscitation (FR), and blunted ..
  58. Clinical, Imaging, and Pathological Studies in the Oldest Old: The 90+ Study
    Claudia H Kawas; Fiscal Year: 2013
    ..hypothesize that normal BP is a risk factor for dementia because daytime and nocturnal BP fluctuations lead to hypotension increasing the risk of microinfarcts and vascular cognitive impairment...
  59. Portable pneumatic driver for counterpulsation therapy
    Paul A Spence; Fiscal Year: 2010
    ..commercially-available 40-ml IABP in a large animal model (n=12) over a range of physiologic conditions (hypotension, hypertenstion, and heart failure) demonstrating feasibility...
  60. Development, testing, and refining the failure to rescue sepsis sniffer
    Andrew M Harrison; Fiscal Year: 2013
    ..diagnosis in a timely and appropriate manner can lead to complications, including organ dysfunction, refractory hypotension, multiple organ dysfunction syndrome, and death...
  61. Sensory C Fibers in the Upper Airways
    THOMAS EDWARD TAYLOR-CLARK; Fiscal Year: 2011
    ..include sneezing, itch, congestion, mucus secretion, bronchospasm, altered respiratory pattern, arterial hypotension and bradycardia...
  62. HIF Mediated Oxygen Sensing in Oligodendrocyte Development and Brain Injury
    John Silbereis; Fiscal Year: 2013
    ..Oxygenation in such infants may be severely disrupted due to either hypoxia (e.g., from respiratory distress, hypotension) or relative hyperoxia (e.g., PaO2 ~60-80 in NICU versus PaO2 ~30-40 in utero...
  63. OBSTETRIC ANESTHESIA: TOCOLYSIS AND HEMORRHAGE
    DAVID CHESTNUT; Fiscal Year: 1993
    ..Obstetrician usually avoid ritodrine in patients at risk for hemorrhage, for fear of severe hypotension. Anesthesiologists often avoid regional anesthesia in patients recently subjected to infusion of either ..
  64. Effects of Vasoactive Drugs on Perfusion in Septic Shock
    Patrick Murray; Fiscal Year: 2005
    ..Sepsis. the systemic inflammatory response to infection. may lead to refractorv hypotension (septic shock) and multiple organ system failure (MOSF)...
  65. CIRCULATORY CONTROL IN CHRONIC HYPOTENSIVE STATES
    ROSE ROBERTSON; Fiscal Year: 1990
    ..Both sympathotonic orthostatic hypotension (SOH), which overlaps clinically with "vasoregulatory" or "neurocirculatory" asthenia and a portion of the ..
  66. PLATELET ACTIVATING FACTOR DEPENDENT TRANSACETYLASES
    TEN CHING LEE; Fiscal Year: 1999
    ..g., liver. lung, and intestines, etc.), bronchoconstriction, systemic hypotension, inflammatory and allergic reactions, implantation and parturition...
  67. Novel non-invasive treatment for hypotension during hemodialysis
    Anja Metzger; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Intradialytic hypotension (IDH) is associated with increased morbidity and mortality and causes delays in patient care during and immediately after dialysis...
  68. Ethyl Nitrite and Subarachnoid Hemorrhage
    Huaxin Sheng; Fiscal Year: 2009
    ..However, nonselective vasodilation also results in complications (e.g., systemic hypotension and steal syndrome) that have limited clinical application...
  69. Mechanisms Mediating Hypotension to Anthrax Lethal Toxin
    Michael J Kenney; Fiscal Year: 2010
    ..These investigators reported that LeTx and ETx infusions produced hypotension;however, mechanisms mediating the depression in arterial blood pressure are not known...
  70. Measuring Intra/Extracellular Volume and Hemodynamics
    Leslie Montgomery; Fiscal Year: 2003
    ..the management of increased intracranial pressure following trauma, the treatment of disequilibrium and hypotension during renal dialysis, the monitoring of hydrational state of premature infants, and the investigation and ..