hypertension

Summary

Summary: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Top Publications

  1. ncbi The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
  2. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
  3. ncbi Prevalence of chronic kidney disease in the United States
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21287, USA
    JAMA 298:2038-47. 2007
  4. ncbi Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    Aram V Chobanian
    Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:1206-52. 2003
  5. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
  6. ncbi 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    Eur Heart J 28:1462-536. 2007
  7. doi US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, 1230 RT, Charleston, SC 29425, USA
    JAMA 303:2043-50. 2010
  8. ncbi Global burden of hypertension: analysis of worldwide data
    Patricia M Kearney
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Lancet 365:217-23. 2005
  9. ncbi 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    J Hypertens 25:1105-87. 2007
  10. ncbi Prospective study of the association between sleep-disordered breathing and hypertension
    P E Peppard
    Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705, USA
    N Engl J Med 342:1378-84. 2000

Detail Information

Publications345 found, 100 shown here

  1. ncbi The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
    ..on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure" provides a new guideline for hypertension prevention and management...
  2. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
    ..To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization..
  3. ncbi Prevalence of chronic kidney disease in the United States
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21287, USA
    JAMA 298:2038-47. 2007
    ..Whether there have been changes in the prevalence of earlier stages of chronic kidney disease (CKD) during this period is uncertain...
  4. ncbi Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    Aram V Chobanian
    Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:1206-52. 2003
    ..Like its predecessors, the purpose is to provide an evidence-based approach to the prevention and management of hypertension. The key messages of this report are these: in those older than age 50, systolic blood pressure (BP) of greater ..
  5. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P <..
  6. ncbi 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    Eur Heart J 28:1462-536. 2007
  7. doi US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, 1230 RT, Charleston, SC 29425, USA
    JAMA 303:2043-50. 2010
    b>Hypertension is a major risk factor for cardiovascular disease and treatment and control of hypertension reduces risk. The Healthy People 2010 goal was to achieve blood pressure (BP) control in 50% of the US population.
  8. ncbi Global burden of hypertension: analysis of worldwide data
    Patricia M Kearney
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Lancet 365:217-23. 2005
    Reliable information about the prevalence of hypertension in different world regions is essential to the development of national and international health policies for prevention and control of this condition...
  9. ncbi 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    J Hypertens 25:1105-87. 2007
  10. ncbi Prospective study of the association between sleep-disordered breathing and hypertension
    P E Peppard
    Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705, USA
    N Engl J Med 342:1378-84. 2000
    ..population-based study of the association between objectively measured sleep-disordered breathing and hypertension (defined as a laboratory-measured blood pressure of at least 140/90 mm Hg or the use of antihypertensive ..
  11. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  12. ncbi Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    Earl S Ford
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
    JAMA 287:356-9. 2002
    ..Limited information is available about the prevalence of the metabolic syndrome in the United States, however...
  13. ncbi Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions
    Manu L N G Malbrain
    Department of Intensive Care, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, 2060, Antwerpen 6, Belgium
    Intensive Care Med 32:1722-32. 2006
    Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) have been increasingly recognized in the critically ill over the past decade...
  14. doi Current and projected prevalence of arterial hypertension in sub-Saharan Africa by sex, age and habitat: an estimate from population studies
    Marc Twagirumukiza
    Faculty of Medicine, National University of Rwanda, Butare, Republic of Rwanda, Belgium
    J Hypertens 29:1243-52. 2011
    In sub-Saharan Africa (SSA), data on hypertension prevalence in terms of urban or rural and sex difference are lacking, heterogeneous or contradictory. In addition, there are no accurate estimates of hypertension burden.
  15. ncbi Waist circumference and not body mass index explains obesity-related health risk
    Ian Janssen
    Department of Community Health and Epidemiology, Queen s University, Kingston, Canada
    Am J Clin Nutr 79:379-84. 2004
    ..The addition of waist circumference (WC) to body mass index (BMI; in kg/m(2)) predicts a greater variance in health risk than does BMI alone; however, whether the reverse is true is not known...
  16. ncbi Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation
    K G M M Alberti
    Department of Endocrinology and Metabolic Medicine, St Mary s Hospital, London, UK and International Diabetes Institute, Caulfield, Australia
    Diabet Med 23:469-80. 2006
    ..An additional aim was to highlight areas where more research into the MetS is needed...
  17. ncbi 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension
    Judith A Whitworth
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Hypertens 21:1983-92. 2003
    b>Hypertension is estimated to cause 4.5% of current global disease burden and is as prevalent in many developing countries, as in the developed world...
  18. doi Prevalence, awareness, treatment, and control of hypertension in China: data from the China National Nutrition and Health Survey 2002
    Yangfeng Wu
    National Institute of Nutrition and Food Safety, Chinese Centre for Disease Control and Prevention, No 29 Nanweilu, Xuanwu District, Beijing 100050, China
    Circulation 118:2679-86. 2008
    The present article aims to provide accurate estimates of the prevalence, awareness, treatment, and control of hypertension in adults in China.
  19. pmc Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities
    Lynn M Boyden
    Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 482:98-102. 2012
    b>Hypertension affects one billion people and is a principal reversible risk factor for cardiovascular disease...
  20. pmc Air pollution and incidence of hypertension and diabetes mellitus in black women living in Los Angeles
    Patricia F Coogan
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave, Boston, MA 02215, USA
    Circulation 125:767-72. 2012
    ..Preliminary epidemiological and clinical evidence suggests that air pollution may contribute to the development of hypertension and type 2 diabetes mellitus.
  21. doi Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study
    MARTIN J O'DONNELL
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    Lancet 376:112-23. 2010
    ....
  22. pmc Association of trypanolytic ApoL1 variants with kidney disease in African Americans
    Giulio Genovese
    Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 329:841-5. 2010
    ..Here, we show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 ..
  23. ncbi Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations
    Michael L Cheatham
    Department of Surgical Education, Orlando Regional Medical Center, 86 West Underwood, Orlando 32806, FL, USA
    Intensive Care Med 33:951-62. 2007
    Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) have been increasingly recognized in the critically ill over the past decade...
  24. pmc Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    M R Law
    Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
    BMJ 338:b1665. 2009
    ..To determine the quantitative efficacy of different classes of blood pressure lowering drugs in preventing coronary heart disease (CHD) and stroke, and who should receive treatment...
  25. ncbi Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circulation 113:1213-25. 2006
    ....
  26. ncbi Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    M Uehata
    Discovery Research Tokyo, Yoshitomi Pharmaceutical Industries Ltd, Saitama, Japan
    Nature 389:990-4. 1997
    Abnormal smooth-muscle contractility may be a major cause of disease states such as hypertension, and a smooth-muscle relaxant that modulates this process would be useful therapeutically...
  27. doi Hypertension in developing countries
    M Mohsen Ibrahim
    Department of Cardiology, Cairo University, Cairo, Egypt
    Lancet 380:611-9. 2012
    Data from different national and regional surveys show that hypertension is common in developing countries, particularly in urban areas, and that rates of awareness, treatment, and control are low...
  28. pmc Relative effectiveness of clinic and home blood pressure monitoring compared with ambulatory blood pressure monitoring in diagnosis of hypertension: systematic review
    J Hodgkinson
    Primary Care Clinical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2PP
    BMJ 342:d3621. 2011
    To determine the relative accuracy of clinic measurements and home blood pressure monitoring compared with ambulatory blood pressure monitoring as a reference standard for the diagnosis of hypertension.
  29. doi Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial
    Ferran Barbe
    Coordinator Centre, IRB Lleida, Lleida, Spain
    JAMA 307:2161-8. 2012
    ..However, its indication for all patients with sleep-disordered breathing, regardless of daytime symptoms, is unclear...
  30. doi The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors
    Julian F Thayer
    The Ohio State University, Department of Psychology, 1835 Neil Avenue, Columbus, Ohio 43210, USA
    Int J Cardiol 141:122-31. 2010
    ..the evidence linking HRV to established and emerging modifiable and non-modifiable CVD risk factors such as hypertension, obesity, family history and work stress...
  31. doi Treatment of hypertension in patients 80 years of age or older
    Nigel S Beckett
    Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
    N Engl J Med 358:1887-98. 2008
    Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
  32. ncbi Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Cou
    Thomas G Pickering
    Hypertension 45:142-61. 2005
    ..monitoring gives a better prediction of risk than office measurements and is useful for diagnosing white-coat hypertension. There is increasing evidence that a failure of blood pressure to fall during the night may be associated with ..
  33. ncbi Hypertension in sub-saharan Africa: a systematic review
    Juliet Addo
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Hypertension 50:1012-8. 2007
    b>Hypertension is an important public health challenge worldwide. Information on the burden of disease from hypertension is essential in developing effective prevention and control strategies...
  34. doi Emergence of chronic non-communicable diseases in China
    Gonghuan Yang
    Chinese Centre for Disease Control and Prevention, Beijing, China Institute of Basic Medical Sciences of Chinese Academy of Medical Sciences and School of Basic Medicine of Peking Union Medical College, Beijing, China
    Lancet 372:1697-705. 2008
    ..China already has 177 million adults with hypertension; furthermore, 303 million adults smoke, which is a third of the world's total number of smokers, and 530 ..
  35. ncbi Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial
    Lawrence J Appel
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md 21205 2233, USA
    JAMA 289:2083-93. 2003
    ..The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP...
  36. pmc Hypertension in sub-Saharan Africa: cross-sectional surveys in four rural and urban communities
    Marleen E Hendriks
    Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands
    PLoS ONE 7:e32638. 2012
    ..of adult mortality in low-income countries but data on the prevalence of cardiovascular risk factors such as hypertension are scarce, especially in sub-Saharan Africa (SSA)...
  37. ncbi Uric acid and the development of hypertension: the normative aging study
    Todd S Perlstein
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hypertension 48:1031-6. 2006
    Experimental evidence supports a causative role for uric acid in the pathogenesis of hypertension. Prospective studies have variably adjusted for relevant confounders and have been of relatively limited duration...
  38. ncbi 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension
    Giuseppe Mancia
    University of Milano Bicocca, Ospedale San Gerardo, Milan, Italy
    J Hypertens 25:1751-62. 2007
  39. pmc H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase
    Guangdong Yang
    Department of Physiology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
    Science 322:587-90. 2008
    ..Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation...
  40. doi Global burden of blood-pressure-related disease, 2001
    Carlene M M Lawes
    Clinical Trials Research Unit, University of Auckland, Auckland, New Zealand
    Lancet 371:1513-8. 2008
    ..Few studies have assessed the extent and distribution of the blood-pressure burden worldwide. The aim of this study was to quantify the global burden of disease related to high blood pressure...
  41. ncbi Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Cou
    Thomas G Pickering
    Circulation 111:697-716. 2005
    ..monitoring gives a better prediction of risk than office measurements and is useful for diagnosing white-coat hypertension. There is increasing evidence that a failure of blood pressure to fall during the night may be associated with ..
  42. ncbi Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States
    Katharina Wolf-Maier
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Ill 60153, USA
    JAMA 289:2363-9. 2003
    Geographic variations in cardiovascular disease (CVD) and associated risk factors have been recognized worldwide. However, little attention has been directed to potential differences in hypertension between Europe and North America.
  43. ncbi European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  44. doi European Society of Hypertension position paper on ambulatory blood pressure monitoring
    Eoin O'Brien
    Eoin O Brien, Gianfranco Parati, and George Stergiou contributed equally to the writing of this article The affiliations of the co authors are listed at the end of the paper, preceding the reference list
    J Hypertens 31:1731-68. 2013
    Ambulatory blood pressure monitoring (ABPM) is being used increasingly in both clinical practice and hypertension research...
  45. doi Trends in prevalence, awareness, management, and control of hypertension among United States adults, 1999 to 2010
    Fangjian Guo
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
    J Am Coll Cardiol 60:599-606. 2012
    ..was to quantify the trends in blood pressure (BP), and the prevalence, awareness, management, and control of hypertension in U.S...
  46. ncbi Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension
    John Deanfield
    Vascular Physiology Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    J Hypertens 23:7-17. 2005
    ..Thus, the most relevant methodological issues in the research on endothelial function and dysfunction are summarized in this paper...
  47. doi A comprehensive review on salt and health and current experience of worldwide salt reduction programmes
    F J He
    Blood Pressure Unit, Cardiac and Vascular Sciences, St George s, University of London, London, UK
    J Hum Hypertens 23:363-84. 2009
    ..The challenge is to spread this out to all other countries. A modest reduction in population salt intake worldwide will result in a major improvement in public health...
  48. doi Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States
    Orfeu M Buxton
    Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Division of Sleep Medicine, BLI 438, 221 Longwood Avenue, Boston, MA 02115, United States
    Soc Sci Med 71:1027-36. 2010
    ..short sleep (<7 h) and long sleep (>8 h) are positively associated with the risk of obesity, diabetes, hypertension, and cardiovascular disease; and analyze 2004-2005 US National Health Interview Survey data (n=56,507 ..
  49. ncbi Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 28:2745-9. 2005
    ..S. adults and to compare it with the prevalence estimated using the definition of the National Cholesterol Education Program (NCEP)...
  50. ncbi Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 37:1236-41. 2001
    ..stiffness and all-cause and cardiovascular mortality remained to be established in patients with essential hypertension. A cohort of 1980 essential hypertensive patients who attended the outpatient hypertension clinic of Broussais ..
  51. doi The quantitative relationship between road traffic noise and hypertension: a meta-analysis
    Elise van Kempen
    National Institute for Public Health and the Environment, Centre for Environmental Health Research, Bilthoven, The Netherlands
    J Hypertens 30:1075-86. 2012
    Reviews have suggested that road noise exposure is associated with high blood pressure (hypertension). No reliable exposure-response relationship is as yet available...
  52. pmc Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
    ..In aortas of mice with deoxycorticosterone acetate-salt (DOCA-salt) hypertension, ROS production from NO synthase is markedly increased, and tetrahydrobiopterin oxidation is evident...
  53. pmc Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)
    Nancy R Cook
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMJ 334:885-8. 2007
    ..To examine the effects of reduction in dietary sodium intake on cardiovascular events using data from two completed randomised trials, TOHP I and TOHP II...
  54. ncbi Major causes of death among men and women in China
    Jiang He
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    N Engl J Med 353:1124-34. 2005
    ..We studied the major causes of death and modifiable risk factors in a nationally representative cohort of 169,871 men and women 40 years of age and older in China...
  55. pmc The Dietary Approaches to Stop Hypertension eating plan affects C-reactive protein, coagulation abnormalities, and hepatic function tests among type 2 diabetic patients
    Leila Azadbakht
    Food Security Research Center and School of Public Health, Isfahan University of Medical Sciences, Isfahan 81745, Iran
    J Nutr 141:1083-8. 2011
    Few studies exist regarding the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on novel cardiovascular risk factors among type 2 diabetic patients...
  56. doi Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD
    D M Mannino
    Dept of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY 40536, USA
    Eur Respir J 32:962-9. 2008
    ..COPD) is associated with important chronic comorbid diseases, including cardiovascular disease, diabetes and hypertension. The present study analysed data from 20,296 subjects aged > or =45 yrs at baseline in the Atherosclerosis ..
  57. pmc ECM remodeling in hypertensive heart disease
    Bradford C Berk
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Clin Invest 117:568-75. 2007
    ..Recent research suggests that therapies targeting the expression, synthesis, or activation of the enzymes responsible for ECM homeostasis might represent novel opportunities to modify the natural progression of HHD...
  58. pmc Vitamin D deficiency and risk of cardiovascular disease
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Circulation 117:503-11. 2008
    ..A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking...
  59. ncbi Is the evolving management of intra-abdominal hypertension and abdominal compartment syndrome improving survival?
    Michael L Cheatham
    Surgical Trauma Intensive Care Unit, Orlando Regional Medical Center, Orlando, FL, USA
    Crit Care Med 38:402-7. 2010
    The diagnosis and management of intra-abdominal hypertension and abdominal compartment syndrome have changed significantly over the past decade with improved understanding of the pathophysiology and appropriate treatment of these disease ..
  60. ncbi Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program
    Paul K Whelton
    Department of Epidemiology and Medicine, Tulane University Health Sciences Center, Tulane University, New Orleans, LA, USA
    JAMA 288:1882-8. 2002
    ..Pressure Education Program Coordinating Committee published its first statement on the primary prevention of hypertension in 1993. This article updates the 1993 report, using new and further evidence from the scientific literature...
  61. ncbi Dietary patterns of adolescents and risk of obesity and hypertension
    Sarah A McNaughton
    Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, 3125 Melbourne, Australia
    J Nutr 138:364-70. 2008
    ..This study suggests that specific dietary patterns are already evident in adolescence and a dietary pattern rich in fruit, salad, cereals, and fish pattern may be associated with diastolic blood pressure in older adolescents...
  62. ncbi Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    Scott M Grundy
    Circulation 110:227-39. 2004
    ..Finally, for people in lower-risk categories, recent clinical trials do not modify the goals and cutpoints of therapy...
  63. doi Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
    Henry Krum
    Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic, Australia
    Lancet 373:1275-81. 2009
    Renal sympathetic hyperactivity is associated with hypertension and its progression, chronic kidney disease, and heart failure...
  64. pmc Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies
    Pasquale Strazzullo
    Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy
    BMJ 339:b4567. 2009
    ..To assess the relation between the level of habitual salt intake and stroke or total cardiovascular disease outcome...
  65. ncbi Trends in hypertension epidemiology in India
    R Gupta
    Department of Medicine, Monilek Hospital and Research Centre, Jawahar Nagar, Jaipur, India
    J Hum Hypertens 18:73-8. 2004
    ..3 million deaths in India in the year 1990; this is projected to double by the year 2020. Hypertension is directly responsible for 57% of all stroke deaths and 24% of all coronary heart disease deaths in India...
  66. ncbi Adherence to medication
    Lars Osterberg
    General Medicine Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    N Engl J Med 353:487-97. 2005
  67. ncbi Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    Yui Pong Siu
    Division of Nephrology, Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Am J Kidney Dis 47:51-9. 2006
    Hyperuricemia is associated strongly with the development of hypertension, renal disease, and progression. Allopurinol decreases serum uric acid levels by inhibiting the enzyme xanthine oxidase...
  68. pmc Comparative effect of olmesartan and candesartan on lipid metabolism and renal function in patients with hypertension: a retrospective observational study
    Yayoi Nishida
    Division of Genomic Epidemiology and Clinical Trials, Advanced Medical Research Center, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Cardiovasc Diabetol 10:74. 2011
    ..However, the effect of prolonged olmesartan monotherapy on lipid metabolism in patients with hypertension is less well studied...
  69. ncbi Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study
    Manu L N G Malbrain
    Medical Intensive Care Unit, ACZA Campus Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerp, Belgium manu malbrain skynet be
    Intensive Care Med 30:822-9. 2004
    Although intra-abdominal hypertension (IAH) can cause dysfunction of several organs and raise mortality, little information is available on the incidence and risk factors for IAH in critically ill patients...
  70. pmc Sex differences in the developmental origins of hypertension and cardiorenal disease
    Jeffrey S Gilbert
    Department of Physiology and Pharmacology, University of Minnesota Medical School Duluth, Duluth, MN 55812, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1941-52. 2008
    ..of the placenta, the presence of critical periods of vulnerability, the involvement of the kidney in programmed hypertension, the presence of sex differences in the progression and development of adult diseases...
  71. ncbi Low-fat dairy consumption and reduced risk of hypertension: the Seguimiento Universidad de Navarra (SUN) cohort
    Alvaro Alonso
    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
    Am J Clin Nutr 82:972-9. 2005
    ..However, no results from prospective studies conducted in a free-living population exist that show this association in middle-aged adults...
  72. doi EUROASPIRE III. Management of cardiovascular risk factors in asymptomatic high-risk patients in general practice: cross-sectional survey in 12 European countries
    Kornelia Kotseva
    Department of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Eur J Cardiovasc Prev Rehabil 17:530-40. 2010
    ..To determine whether the 2003 Joint European Societies' guidelines on cardiovascular disease prevention in people at high cardiovascular risk have been followed in general practice...
  73. pmc Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
    M Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    BMJ 322:1447-51. 2001
    ..To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life...
  74. ncbi [2010 Chinese guidelines for the management of hypertension]
    Li Sheng Liu
    Zhonghua Xin Xue Guan Bing Za Zhi 39:579-615. 2011
    The 2010 Chinese guidelines for the management of hypertension is an update of the previous versions in 2005 and 1999...
  75. doi Salt intakes around the world: implications for public health
    Ian J Brown
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, UK
    Int J Epidemiol 38:791-813. 2009
    ..Comprehensive, contemporaneous sodium intake data from around the world are needed to inform national/international public health initiatives to reduce sodium consumption...
  76. ncbi Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
    Richard J Johnson
    Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 86:899-906. 2007
    Currently, we are experiencing an epidemic of cardiorenal disease characterized by increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney disease...
  77. pmc Incidence and prognosis of resistant hypertension in hypertensive patients
    Stacie L Daugherty
    Division of Cardiology, University of Colorado Denver, 12605 E 16th Ave, Aurora, CO 80045, USA
    Circulation 125:1635-42. 2012
    Despite a recent American Heart Association (AHA) consensus statement emphasizing the importance of resistant hypertension, the incidence and prognosis of this condition are largely unknown.
  78. pmc From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene
    Ying Wang
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 106:226-31. 2009
    b>Hypertension places a major burden on individual and public health, but the genetic basis of this complex disorder is poorly understood...
  79. ncbi Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
    Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for this association...
  80. pmc A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
    The evidence for the existence of genetic susceptibility variants for the common form of hypertension ("essential hypertension") remains weak and inconsistent...
  81. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
    ..a soluble factor or factors that cause maternal endothelial dysfunction, resulting in the clinical findings of hypertension, proteinuria, and edema...
  82. doi Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure
    Brent A Dickinson
    miRagen Therapeutics, 6200 Lookout Rd, Boulder, CO 80301, USA
    Eur J Heart Fail 15:650-9. 2013
    ..The aim of this study is to determine if plasma miRNAs can be used as indicators of disease progression or therapeutic efficacy in hypertension-induced heart disease.
  83. ncbi Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
    ..Developmentally programmed hyperphagia, physical inactivity, and altered adipocyte metabolism may play a mechanistic role...
  84. doi G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms
    Gaetano Santulli
    Department of Advanced Biomedical Sciences, Federico II University of Naples, 80131, Naples, Italy
    High Blood Press Cardiovasc Prev 20:5-12. 2013
    ..This review attempts to assemble the currently available information concerning GRK2 and hypertension, opening new potential fields of translational investigation to treat this vexing disease.
  85. doi A controlled trial of renal denervation for resistant hypertension
    Deepak L Bhatt
    From Brigham and Women s Hospital Heart and Vascular Center and Harvard Medical School D L B, L M, Boston University School of Public Health R D, and Harvard Clinical Research Institute R D, L M all in Boston Piedmont Heart Institute, Atlanta D E K the Division of Cardiology, Henry Ford Hospital W W O, and Wayne State University and the Detroit Medical Center J M F all in Detroit Baptist Cardiac and Vascular Institute, Miami B T K New York Presbyterian Hospital, Columbia University Medical Center, and Cardiovascular Research Foundation, New York M B L Medtronic CardioVascular, Santa Rosa, CA M L, M N, S A C University of Alabama at Birmingham, Birmingham S O Prairie Heart Institute, Springfield, IL K R S Perelman School of Medicine, University of Pennsylvania, Philadelphia S A C, R R T and University of Chicago Medicine, Chicago G L B
    N Engl J Med 370:1393-401. 2014
    Prior unblinded studies have suggested that catheter-based renal-artery denervation reduces blood pressure in patients with resistant hypertension.
  86. pmc The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease
    Hiroyuki Kobori
    Department of Medicine, Director of the Molecular Core in Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Pharmacol Rev 59:251-87. 2007
    ..recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the pathophysiology of hypertension and organ injury has changed to a major emphasis on the role of the local RAS in specific tissues...
  87. doi Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries
    Clara K Chow
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    JAMA 310:959-68. 2013
    b>Hypertension is the most important preventable cause of morbidity and mortality globally, yet there are relatively few data collected using standardized methods.
  88. ncbi Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure
    Yuji Okura
    Division of Cardiovascular Diseases and Internal Medicine, Department of Health Science Research, Mayo Clinic and Foundation, 200 First St SW, Rochester, Minnesota 55905, USA
    J Clin Epidemiol 57:1096-103. 2004
    ..Agreement between questionnaire responses and a criterion standard is important for optimal disease prevalence estimates. We measured the agreement between self-reported disease and medical record diagnosis of disease...
  89. ncbi Hypertension in sub-Saharan African populations
    Lionel H Opie
    Hatter Institute for Cardiology Research, University of Cape Town, Cape Town, South Africa
    Circulation 112:3562-8. 2005
    b>Hypertension in sub-Saharan Africa is a widespread problem of immense economic importance because of its high prevalence in urban areas, its frequent underdiagnosis, and the severity of its complications.
  90. ncbi Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice
    Anna Dikalova
    Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Circulation 112:2668-76. 2005
    ..Nox1 upregulation has been implicated in cardiovascular pathologies such as hypertension and restenosis.
  91. ncbi Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis
    Tazeen H Jafar
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 139:244-52. 2003
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease...
  92. ncbi Human hypertension caused by mutations in WNK kinases
    F H Wilson
    Howard Hughes Medical Institute Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510 USA
    Science 293:1107-12. 2001
    b>Hypertension is a major public health problem of largely unknown cause...
  93. ncbi Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV
    B Williams
    Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, University of Leicester, UK
    J Hum Hypertens 18:139-85. 2004
  94. doi Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Lancet 375:895-905. 2010
    The mechanisms by which hypertension causes vascular events are unclear. Guidelines for diagnosis and treatment focus only on underlying mean blood pressure...
  95. pmc Inflammatory cytokines in vascular dysfunction and vascular disease
    Alexander H Sprague
    Division of Vascular Surgery and Endovascular Therapy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biochem Pharmacol 78:539-52. 2009
    ..dysfunction and vascular disease such as atherosclerosis, abdominal aortic aneurysm, varicose veins and hypertension. Genetic and pharmacological tools to decrease the production of cytokines or to diminish their effects using ..
  96. pmc Predictive validity of a medication adherence measure in an outpatient setting
    Donald E Morisky
    Department of Community Health Sciences, UCLA School of Public Health, Los Angeles, CA 90095 1772, USA
    J Clin Hypertens (Greenwich) 10:348-54. 2008
    ..concurrent and predictive validity of a structured, self-reported medication adherence measure in patients with hypertension. The authors also assessed various psychosocial determinants of adherence, such as knowledge, social support, ..
  97. ncbi Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults
    Bei fan Zhou
    Institute of Cardiovascular Disease, Chinese Academy of Medical Sciences
    Biomed Environ Sci 15:83-96. 2002
    ..g., high diabetes, diabetes mellitus, and lipoprotein disorders)...
  98. ncbi Overweight and obesity as determinants of cardiovascular risk: the Framingham experience
    Peter W F Wilson
    Boston University School of Medicine, 715 Albany St, Evans 204, Boston, MA 02118, USA
    Arch Intern Med 162:1867-72. 2002
    To our knowledge, no single investigation concerning the long-term effects of overweight status on the risk for hypertension, hypercholesterolemia, diabetes mellitus, and cardiovascular sequelae has been reported.
  99. doi Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004
    Jeffrey A Cutler
    US Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hypertension 52:818-27. 2008
    This study assesses trends in hypertension prevalence, blood pressure distributions and mean levels, and hypertension awareness, treatment, and control among US adults, age >or=18 years, between the third National Health and Nutrition ..
  100. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  101. pmc Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence
    Amanda E Boe
    Department of Medicine A E B, M E, S B M, C E K, D E V and Feinberg Cardiovascular Research Institute A E B, S B M, C E K, D E V, Northwestern University Feinberg School of Medicine, Chicago, IL United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, Miyagi, Japan A I, T M and Conrad Prebys Center for Chemical Genomics D T, D M, L H S and Cardiopathobiology Program, Diabetes and Obesity Research Center D M, L H S, Sanford Burnham Medical Research Institute at Lake Nona, Orlando FL
    Circulation 128:2318-24. 2013
    ..such as N(ω)-nitro-l-arginine methyl ester (L-NAME) has been shown to induce senescence in vitro and systemic hypertension and arteriosclerosis in vivo...

Research Grants82

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..goals include expanded screening for cardiac iron deposition using newly available MRI technology and pulmonary hypertension. Indications of research hypotheses and research questions to be addressed and answered throughout the life of ..
  3. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..a serious condition in which inflammation kills liver cells, ultimately culminating in liver cirrhosis, portal hypertension, and liver failure...
  4. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..Recent evidence indicates that untreated OSA carries increased risk for the development of hypertension, myocardial infarction, and stroke...
  5. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..SCD patients suffer from chronic, progressive vasculopathy leading to pulmonary hypertension, renal failure and stroke...
  6. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary: Obesity, lipodystrophy, diabetes and hypertension collectively constitute "Metabolic Syndrome" (MS)...
  7. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hypertension is a major public health concern in the U.S. with ~70 million adults affected including Veterans...
  8. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    Short sleep duration (<6 hours/night) is associated with a higher prevalence and incidence of hypertension, diabetes, and overweight/obesity, all of which can contribute to coronary heart disease...
  9. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..insulin sensitivity is a cardinal feature of various pathological conditions such as type 2 diabetes and hypertension. Recent research has implicated a heightened renin-angiotensin-aldosterone system (RAAS) and associated ..
  10. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..to understanding the effects of hypoxia on the cardiovascular system and the pathology of OSA, particularly the hypertension associated with this disease...
  11. Right ventricular contractile dysfunction after pressure overload
    CLIFFORD RUSSELL GREYSON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Right ventricular (RV) contractile failure from acute pulmonary hypertension is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary ..
  12. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..However, current demographics show a high incidence of obesity, hypertension, and diabetes in young adults that herald a large increase in heart disease and cardiovascular mortality...
  13. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..by applicant): Diminished insulin (INS) sensitivity is a common feature of disease states such as obesity, hypertension and diabetes...
  14. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..Therefore, urea transporter is a potential drug target for treating a variety of conditions ranging from hypertension, congestive heart failure, to syndrome of inappropriate secretion of antidiuretic hormone compounds (SIADH)...
  15. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..microvasculature is also an important therapeutic goal for interstitial fibrosis and other causes of pulmonary hypertension. A critical step towards achieving this goal is to identify factors which regulate capillary expansion and ..
  16. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    ..G4+/-) represents an example of an `At Risk'individual as male G4+/- mice develop insulin resistance, hypertension and T2DM with age...
  17. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..are powerful modulators of baroreflex sensitivity and autonomic activity capable of preventing or reversing hypertension. The specific aims of the proposed research are to: (1) Determine whether selective overexpression of RAMP1 in ..
  18. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..a large family with autosomal dominant early onset coronary artery disease (CAD), diabetes, hyperlipidemia, and hypertension. The mutation, substitutes cysteine for arginine (R611C) at a highly conserved residue of the second epidermal ..
  19. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disease of the pulmonary circulation affecting children and adults...
  20. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..Inhibition of the PGE2 synthetic pathway is associated with avid renal Na reabsorption and the development of hypertension, suggesting a critical role for PGE2 in the maintenance of Na balance and blood pressure...
  21. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..organ damage in full-blown disease, a model that is seen in other vascular insults such as hyperglycemia, hypertension and hyperlipidemia...
  22. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..Specifically, dysregulation of the Na,K-ATPase has been attributed to hypertension, congestive heart failure, familial hemiplegic migraine, epileptogenesis, and polycystic kidney disease...
  23. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..Human WNK gain-of-function mutations lead to hypertension and hyperkalemia, and loss-of-function mutations in WNK and SPAK lead to renal salt wasting and hypotension in ..
  24. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..Some metabolic disorders associated with aberrant ovarian steroid secretion are hypertension, diabetes, obesity, osteoporosis, polycystic ovary syndrome and neoplasms of the colon, breast, ovary, and ..
  25. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..the phagocyte NADPH-oxidase) are implicated in animal models of Angiotensin II-induced of atherosclerosis and hypertension. VPO, when co- expressed in cells with novel vascular Noxes, utilizes hydrogen peroxide produced by these Noxes ..
  26. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    Project Summary Persistent pulmonary hypertension of the newborn (PPHN) is a condition that results from failure of pulmonary vasodilation to occur at birth...
  27. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..work has been driven by a lack of understanding of the mechanisms responsible for the development of essential hypertension. There is little doubt that augmented sympathetic nerve activity contributes to the pathogenesis of a variety ..
  28. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..factor clustering: a combination of risk factors including central obesity, hyperglycemia, dyslipidemia, and hypertension)...
  29. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hypertension (HTN) is a leading cause of morbidity and mortality worldwide, contributing to cardiovascular disease, stroke, and end stage kidney disease...
  30. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..epidemic of obesity that now affects 30% of the adult population, and the resultant increase in heart disease, hypertension, diabetes, joint dysfunction, stroke, cancer, and early death that is estimated to cost upwards of 75 billion ..
  31. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    Diabetes mellitus is associated with a cardiomyopathy that occurs in the absence of hypertension or coronary artery disease and that is characterized by ventricular hypertrophy, decreased ventricular diastolic relaxation, and a reduced ..
  32. Expression of sFlt1 and its function in the glomerular endothelium
    Christie P Thomas; Fiscal Year: 2013
    ..a soluble VEGF receptor antagonist, sFlt1, in rats and mice lead to the development of severe proteinuria and hypertension accompanied by glomerular endotheliosis...
  33. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..HF induced by genetic or specific conditions, such as coronary artery disease, hypertension, diabetes, infection, or inflammation results in a heterogeneous myocardium consisting of a mixture of ..
  34. INTERNET ENHANCED HEALTH PROMOTION FOR OBESE ETHNIC MINORITY ADOLESCENTS
    Jessica A Whiteley; Fiscal Year: 2011
    ..Co-morbid conditions are increasingly seen in obese youth, including insulin resistance, type 2 diabetes, hypertension, obstructive sleep apnea, poor self-esteem, lower health-related quality of life (Rashid &Roberts, 2000;..
  35. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..Both hormones play a role in the pathogenesis of hypertension, cardiovascular fibrosis, and nephrosclerosis...
  36. The genetics and pathophysiology of impaired Wnt signaling in metabolic syndrome
    Arya Mani; Fiscal Year: 2012
    ..in large kindreds with autosomal dominant premature coronary artery disease (CAD), diabetes hyperlipidemia, hypertension, and osteoporosis we have identified the disease causing mutations that substitute evolutionarily highly ..
  37. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    Activation of the mineralocorticoid receptor (MR) is implicated in clinical hypertension and target organ damage even in patients who have normal or low plasma aldosterone levels...
  38. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..route for 3 weeks, a period characterized in this model system by progressive lung fibrosis, pulmonary arterial hypertension (PAH), and hypoalveolarization...
  39. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..mice resulted in hyperglycemia, hyperlipidemia, hyperphagia, insulin resistance, obesity, hepatic steatosis and hypertension, collectively referred to as metabolic syndrome...
  40. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..However, both hypertension and hypotension are poorly treated because many patients often are unwilling to use standard medical therapy...
  41. Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary Hypertension
    C Michael Hart; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pulmonary hypertension (PH) is a devastating cardiopulmonary disorder with significant morbidity and mortality that frequently complicates disorders that affect the veteran patient population...
  42. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..Nearly one third of the Veterans have ischemic heart disease and another third have hypertension and/or aortic valve stenosis, which cause heart failure...
  43. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..Pulmonary arterial hypertension (PAH) is a syndrome characterized by obstructive vascular remodeling, inflammation and vasoconstriction of ..
  44. A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia
    Prakash Jagtap; Fiscal Year: 2013
    ..range for 3 weeks, a period characterized in this model system by progressive lung fibrosis, pulmonary arterial hypertension (PAH), and hypoalveolarization...
  45. JACKSON HEART STUDY
    Herman Taylor; Fiscal Year: 2010
    ..have high rates of modifiable CVD risk factors and their cardiovascular consequences, particularly for hypertension, are often more severe...
  46. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..have high rates of modifiable CVD risk factors and their cardiovascular consequences, particularly for hypertension, are often more severe...
  47. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..have high rates of modifiable CVD risk factors and their cardiovascular consequences, particularly for hypertension, are often more severe...
  48. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..have been linked to increasingly prevalent diseases, including atherosclerosis, obesity, type II diabetes, and hypertension (all associated with metabolic syndrome), as well as lipodystrophy, Alzheimers Disease, and certain cancers, ..
  49. A Rodent Model to Study Links Among Diet, Visceral Adipose and Cardiomyopathy
    MELINDA ANN FRYE; Fiscal Year: 2013
    ..Obese individuals are at higher risk for cardiomyopathy and heart failure, even in the absence of hypertension or ischemic disease. Two principle gaps in our understanding of obesity-mediated cardiomyopathy (OC) exist...
  50. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2013
    ..have high rates of modifiable CVD risk factors and their cardiovascular consequences, particularly for hypertension, are often more severe...
  51. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..Common clinical conditions, including aging, insulin resistance, diabetes and hypertension per se are associated with loss of this elastance function, predisposing to systolic hypertension...
  52. Modifiers of Cyst Progression in Polycystic Kidney Disease
    Phillip Darwin Bell; Fiscal Year: 2013
    ..There are also cardiovascular effects including hypertension and stroke...
  53. Interactions of the RAAS and a Western Diet on Insulin Metabolic Actions
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..Summary/Abstract Impaired insulin (INS) sensitivity is a common feature of disease states such as obesity, hypertension and diabetes...
  54. Comparative effectiveness of diabetes prevention strategies in women with GDM
    Assiamira Ferrara; Fiscal Year: 2010
    ..strategies in women with gestational diabetes (GDM) for improving the following: obesity, hyperglycemia, hypertension and depression in a real-world clinical setting...
  55. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..supports the hypothesis that increased levels of EDLF may be a causative factor in the pathogenesis of hypertension. Recently, marinobufagenin (MBG), an endogenous cardiotonic steroid (CTS), has been identified as the EDLF...
  56. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..Consequences of untreated sleep apnea include increased daytime fatigue, hypertension and stroke. Thus, sleep apnea is a major health concern...
  57. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..unprepared for ex utero function and rapidly develops edema, poor compliance, pulmonary arterial hypertension (PAH), and impaired gas exchange...
  58. JACKSON HEART STUDY
    Asoka Srinivasan; Fiscal Year: 2010
    ..have high rates of modifiable CVD risk factors and their cardiovascular consequences, particularly for hypertension, are often more severe...
  59. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2011
    ..have high rates of modifiable CVD risk factors and their cardiovascular consequences, particularly for hypertension, are often more severe...
  60. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..Individuals with tetraplegia also have increased prevalence of extreme hypertension, commonly diagnosed as autonomic dysreflexia (AD) (1, 6, 9)...
  61. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Essential hypertension is common, affecting 50 million adults in the United States and is a leading cause of cardiovascular death...
  62. Integrative Cardiovascular Control During Exercise in Hypertension
    DONAL S O apos LEARY; Fiscal Year: 2010
    b>Hypertension affects nearly 1 in 3 of all adults in the U.S. and is well recognized as a major risk factor for a broad range of cardiovascular diseases such as stroke, congestive heart failure, renal disease, and congestive heart failure...
  63. EPIDEMIC HYPERTENSION IN NIGERIAN WORKERS
    Clareann Bunker; Fiscal Year: 1999
    Our study of Epidemic Hypertension in Nigerian Workers has successfully recruited 501 male and 303 female civil servants, ages 20-64, in Benin City, a population of genetic relevance to U.S. blacks...
  64. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..safer and more effective administration of life-prolonging drugs such as prostacyclines for pulmonary arterial hypertension"...
  65. Using a Telemedicine System to Promote Patient Care Among Underserved Individuals
    Alfred Bove; Fiscal Year: 2009
    b>Hypertension affects more than 65 million people in the US with African Americans disproportionably affected. Untreated hypertension is associated with an increased risk for myocardial infractions, sudden death, stroke, and renal failure...
  66. Arterial Baroreflex Function in African Americans at Rest and During Exercise
    David Keller; Fiscal Year: 2009
    ..African Americans are at higher risk than their Caucasian American counterparts for the development of hypertension with hypertension affecting over 40% of the African American adult population...
  67. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
    Intrauterine growth restricted newborns have an increased risk of adult obesity, hypertension and coronary heart disease. Obesity alone accounts for 65-78% of essential hypertension...
  68. Nurses' Health Study: Short Sleep Duration and Risk of Hypertension
    JAMES GANGWISCH; Fiscal Year: 2009
    Short sleep duration has been shown to be associated with an increased risk for hypertension incidence, but previous prospective studies on this association did not examine the potential effect modifiers of menopausal status, hormone ..
  69. Childhood Origins for Cardiac Structure and Function
    Shumei S Sun; Fiscal Year: 2012
    ..obesity that has affected children and adolescents in this country has led to an increased prevalence of hypertension in these age groups...
  70. Primary Prevention of Hypertension in Obese Adolescents
    Daniel Feig; Fiscal Year: 2006
    b>Hypertension affects 25% of the world population. It is the number one cause of stroke and heart failure and the second most common cause of end stage renal disease. In the USA the prevalence of hypertension exceeds 50 million...
  71. SPLANCHNIC HEMODYNAMICS IN PORTAL HYPERTENSION
    JAMES SITZMANN; Fiscal Year: 1992
    Portal hypertension is one of the more serious clinical complications of advanced liver disease...
  72. Genotypes, Haplotypes, and Blood Pressure Change from Childhood to Adulthood
    DAVID MICHAEL HALLMAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hypertension affects nearly one-third of adults over age 20 in the United States...
  73. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2005
    b>Hypertension remains as a major risk factor for a multitude of cardiovascular diseases, and as such it is responsible for significant morbidity and mortality...
  74. Genetic Risk Factors for Portopulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    Patients with portal hypertension are at increased risk of pulmonary hypertension (termed portopulmonary hypertension). Patients with portopulmonary hypertension suffer from increased morbidity and mortality...
  75. Functional characterization of ATP1A1 and DEspR variants associated with essentia
    Nelson Ruiz Opazo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Project Summary Essential hypertension is a major public health concern due to its high prevalence and its role as a leading risk factor for leading causes of death and morbidity in the developed ..
  76. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    Erik Schwiebert; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis Scientific Summary Description Hypertension is a confounding multifactorial disorder that affects millions of patients worldwide...
  77. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hypertension is a major risk factor for .cardiovascular and renal diseases...