venous thrombosis

Summary

Summary: The formation or presence of a thrombus within a vein.

Top Publications

  1. ncbi Incidence and mortality of venous thrombosis: a population-based study
    I A Naess
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    J Thromb Haemost 5:692-9. 2007
  2. ncbi The epidemiology of venous thromboembolism
    Richard H White
    University of California, Davis, Sacramento, California, USA
    Circulation 107:I4-8. 2003
  3. ncbi Pulmonary embolism and deep vein thrombosis
    Samuel Z Goldhaber
    Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Cardiovascular Division, Boston, MA 02115, USA
    Lancet 379:1835-46. 2012
  4. ncbi Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    Bengt I Eriksson
    Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    N Engl J Med 358:2765-75. 2008
  5. ncbi Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study
    J A Heit
    Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Arch Intern Med 160:809-15. 2000
  6. ncbi Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    Michael R Lassen
    Nordsjaellands Hospital, Hørsholm, Denmark
    N Engl J Med 358:2776-86. 2008
  7. ncbi Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial
    Alexander G G Turpie
    McMaster University, Hamilton, Ontario L8L 2X2, Canada
    Lancet 373:1673-80. 2009
  8. pmc Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
    Marie Luise von Brühl
    Deutsches Herzzentrum and I Medizinische Klinik, Technische Universität München TUM, 80333 Munich, Germany
    J Exp Med 209:819-35. 2012
  9. ncbi Prognosis of cancers associated with venous thromboembolism
    H T Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    N Engl J Med 343:1846-50. 2000
  10. ncbi Ruling out deep venous thrombosis in primary care. A simple diagnostic algorithm including D-dimer testing
    Ruud Oudega
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 94:200-5. 2005

Research Grants

  1. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
  2. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2012
  3. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
  4. STRUCTURE AND FUNCTION OF HEPARIN COFACTOR II
    Douglas M Tollefsen; Fiscal Year: 2010
  5. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
  6. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
  7. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
  8. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
  9. Chemopreventative properties of Medicinal and Food plants of the Lumbee Tribe
    TRACIE LOCKLEAR; Fiscal Year: 2010
  10. Structural and Biochemical Basis of the Vitamin K cycle
    Weikai Li; Fiscal Year: 2013

Detail Information

Publications387 found, 100 shown here

  1. ncbi Incidence and mortality of venous thrombosis: a population-based study
    I A Naess
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    J Thromb Haemost 5:692-9. 2007
    Estimates of the incidence of venous thrombosis (VT) vary, and data on mortality are limited.
  2. ncbi The epidemiology of venous thromboembolism
    Richard H White
    University of California, Davis, Sacramento, California, USA
    Circulation 107:I4-8. 2003
    ..Early mortality after VTE is strongly associated with presentation as PE, advanced age, cancer, and underlying cardiovascular disease...
  3. ncbi Pulmonary embolism and deep vein thrombosis
    Samuel Z Goldhaber
    Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Cardiovascular Division, Boston, MA 02115, USA
    Lancet 379:1835-46. 2012
    ..In this Seminar, we discuss pulmonary embolism and deep vein thrombosis of the legs...
  4. ncbi Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    Bengt I Eriksson
    Sahlgrenska University Hospital Ostra, Gothenburg, Sweden
    N Engl J Med 358:2765-75. 2008
    ..This phase 3 trial compared the efficacy and safety of rivaroxaban, an oral direct inhibitor of factor Xa, with those of enoxaparin for extended thromboprophylaxis in patients undergoing total hip arthroplasty...
  5. ncbi Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study
    J A Heit
    Division of Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Arch Intern Med 160:809-15. 2000
    ..Reported risk factors for venous thromboembolism (VTE) vary widely, and the magnitude and independence of each are uncertain...
  6. ncbi Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    Michael R Lassen
    Nordsjaellands Hospital, Hørsholm, Denmark
    N Engl J Med 358:2776-86. 2008
    We investigated the efficacy of rivaroxaban, an orally active direct factor Xa inhibitor, in preventing venous thrombosis after total knee arthroplasty.
  7. ncbi Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial
    Alexander G G Turpie
    McMaster University, Hamilton, Ontario L8L 2X2, Canada
    Lancet 373:1673-80. 2009
    ..We aimed to test the efficacy and safety of oral rivaroxaban for the prevention of venous thromboembolism after total knee arthroplasty...
  8. pmc Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
    Marie Luise von Brühl
    Deutsches Herzzentrum and I Medizinische Klinik, Technische Universität München TUM, 80333 Munich, Germany
    J Exp Med 209:819-35. 2012
    ..Hence, we identified a cross talk between monocytes, neutrophils, and platelets responsible for the initiation and amplification of DVT and for inducing its unique clinical features...
  9. ncbi Prognosis of cancers associated with venous thromboembolism
    H T Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    N Engl J Med 343:1846-50. 2000
    ..Little is known about the prognosis of cancer discovered during or after an episode of venous thromboembolism...
  10. ncbi Ruling out deep venous thrombosis in primary care. A simple diagnostic algorithm including D-dimer testing
    Ruud Oudega
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 94:200-5. 2005
    ....
  11. pmc Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Shannon M Bates
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
    Chest 141:e351S-418S. 2012
    ..This guideline focuses on the identification of optimal strategies for the diagnosis of DVT in ambulatory adults...
  12. pmc Genetics of venous thrombosis: insights from a new genome wide association study
    Marine Germain
    INSERM UMR_S 937 ICAN Institute, Universite Pierre et Marie Curie, Paris 6, Paris, France
    PLoS ONE 6:e25581. 2011
    b>Venous Thrombosis (VT) is a common multifactorial disease associated with a major public health burden...
  13. ncbi Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis
    Philip S Wells
    Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, Ont, Canada
    N Engl J Med 349:1227-35. 2003
    ....
  14. ncbi Malignancies, prothrombotic mutations, and the risk of venous thrombosis
    Jeanet W Blom
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:715-22. 2005
    b>Venous thrombosis is a common complication in patients with cancer, leading to additional morbidity and compromising quality of life.
  15. ncbi Multidetector computed tomography for acute pulmonary embolism
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
    N Engl J Med 354:2317-27. 2006
    ..The accuracy of multidetector computed tomographic angiography (CTA) for the diagnosis of acute pulmonary embolism has not been determined conclusively...
  16. ncbi The risk of recurrent venous thromboembolism in men and women
    Paul A Kyrle
    Department of Internal Medicine I, Division of Hematology and Hemostasis, Ludwig Boltzmann Institut fur Thromboseforschung, Vienna, Austria
    N Engl J Med 350:2558-63. 2004
    ..Whether a patient's sex is associated with the risk of recurrent venous thromboembolism is unknown...
  17. ncbi Electronic alerts to prevent venous thromboembolism among hospitalized patients
    Nils Kucher
    Department of Medicine, Cardiovascular Division, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 352:969-77. 2005
    ..We hypothesized that the use of a computer-alert program to encourage prophylaxis might reduce the frequency of deep-vein thrombosis among high-risk hospitalized patients...
  18. pmc Inflammation, TNFα and endothelial dysfunction link lenalidomide to venous thrombosis in chronic lymphocytic leukemia
    Georg Aue
    Hematology Branch, NHLBI, NIH, Bethesda, Maryland 20892 1202, USA
    Am J Hematol 86:835-40. 2011
    Patients receiving lenalidomide are at an increased risk for deep venous thrombosis (DVT). Here, we prospectively investigated the DVT risk in patients with relapsed chronic lymphocytic leukemia (CLL) treated with lenalidomide (n = 32)...
  19. ncbi Integrated strategies for the diagnosis of venous thromboembolism
    P S Wells
    Department of Medicine, Ottawa Hospital, Ottawa Health Research Institute, and the University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 5:41-50. 2007
    ..These integration strategies result in safer, more convenient and cost-effective care for patients...
  20. ncbi An association between atherosclerosis and venous thrombosis
    Paolo Prandoni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy
    N Engl J Med 348:1435-41. 2003
    ..Whether atherosclerosis is associated with an increased risk of venous thrombosis is unknown.
  21. ncbi Cerebral venous thrombosis: an update
    Marie Germaine Bousser
    AP HP Hôpital Lariboisière Service de Neurologie, Paris, France
    Lancet Neurol 6:162-70. 2007
    Cerebral venous thrombosis (CVT) is a rare type of cerebrovascular disease that can occur at any age, including in neonates, and it accounts for 0.5% of all stroke...
  22. pmc Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial
    M Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Bramwell Dott Building, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 373:1958-65. 2009
    ..National stroke guidelines extrapolating from these trials recommend their use in patients with stroke despite insufficient evidence. We assessed the effectiveness of thigh-length GCS to reduce DVT after stroke...
  23. pmc Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial
    Alexander T Cohen
    Department of Surgery, Guy s, King s, and St Thomas s School of Medicine, London SE5 9PJ
    BMJ 332:325-9. 2006
    ..To determine the efficacy and safety of the anticoagulant fondaparinux in older acute medical inpatients at moderate to high risk of venous thromboembolism...
  24. ncbi The role of ethnicity, age and gender in venous thromboembolism
    Martina Montagnana
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita di Verona, Ospedale Policlinico G B Rossi, Piazzale Scuro, Verona, Italy
    J Thromb Thrombolysis 29:489-96. 2010
    Venous thromboembolism, including both deep venous thrombosis and pulmonary embolism, is the leading cause of preventable in-hospital mortality...
  25. ncbi Endovascular treatment options in the management of lower limb deep venous thrombosis
    Sarfraz Ahmed Nazir
    Department of Radiology, John Radcliffe Hospital, Headley Way, Oxford, UK
    Cardiovasc Intervent Radiol 32:861-76. 2009
    ..This article reviews these technologies and discusses their current role as percutaneous treatment strategies for venous thrombotic conditions...
  26. ncbi Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis
    Paolo Prandoni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 100:3484-8. 2002
    ..Cancer patients with venous thrombosis are more likely to develop recurrent thromboembolic complications and major bleeding during anticoagulant ..
  27. ncbi Prospective study of color duplex ultrasonography compared with contrast venography in patients suspected of having deep venous thrombosis of the upper extremities
    Henk Jan Baarslag
    Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Ann Intern Med 136:865-72. 2002
    The optimal strategy for diagnosis of deep venous thrombosis (DVT) is less well established for the upper extremities than for the lower extremities...
  28. ncbi Catheter-related upper extremity deep venous thrombosis in cancer patients: a prospective study based on Doppler US
    A Luciani
    Department of Radiology, , 20 rue Leblanc, 75908 Paris Cedex 15, France
    Radiology 220:655-60. 2001
    ..Doppler ultrasonography (US) to estimate the incidence of asymptomatic catheter-related upper extremity deep venous thrombosis (DVT) in a large population and (b) to study the effect of the catheter position as an individual risk ..
  29. ncbi Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery: a meta-analysis of 4 randomized double-blind studies
    Alexander G G Turpie
    Department of Medicine, Hamilton Health Sciences General Hospital, 237 Barton, Hamilton, Ontario, Canada L8L 2X2
    Arch Intern Med 162:1833-40. 2002
    ..Fondaparinux, the first of a new class of synthetic selective factor Xa inhibitors, may further reduce this risk compared with currently available thromboprophylactic treatments...
  30. ncbi Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study
    John A Heit
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 143:697-706. 2005
    ..The risk for venous thromboembolism during pregnancy or postpartum is uncertain...
  31. ncbi Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study
    John A Heit
    Hematology Research, Stabile 660, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Intern Med 162:1245-8. 2002
    ....
  32. ncbi Deep-vein thrombosis: a United States cost model for a preventable and costly adverse event
    Charles E Mahan
    University of New Mexico College of Pharmacy, Albuquerque, New Mexico, USA
    Thromb Haemost 106:405-15. 2011
    ..8 to $52 billion, $6.8 to $36 billion, and $3.4 to $27 billion, respectively...
  33. ncbi The metabolic syndrome and the risk of venous thrombosis: a case-control study
    W Ageno
    Department of Clinical Medicine, University of Insubria, Varese, Italy
    J Thromb Haemost 4:1914-8. 2006
    ..The metabolic syndrome is a cluster of risk factors for atherosclerosis. Its impact on VTE is unknown...
  34. ncbi Idiopathic venous thrombosis is related to systemic inflammatory response and to increased levels of circulating markers of endothelial dysfunction
    M K Jezovnik
    Department of Vascular Disease, University Medical Centre Ljubljana, Slovenia
    Int Angiol 29:226-31. 2010
    ..However, little is known about the relationship between inflammation and venous thrombosis. Recently, inflammation has been accepted as a possible mechanism through which different risk factors ..
  35. ncbi Effect of postthrombotic syndrome on health-related quality of life after deep venous thrombosis
    Susan R Kahn
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste, Catherine Room A 114, Montreal, Quebec, Canada H3T 1E2
    Arch Intern Med 162:1144-8. 2002
    Postthrombotic syndrome (PTS) is a frequent chronic complication of deep venous thrombosis, yet its impact on health-related quality of life has not been well characterized...
  36. ncbi Combined use of clinical assessment and d-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study)
    D R Anderson
    Department of Medicine, QEII Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
    J Thromb Haemost 1:645-51. 2003
    ..5%) developed pulmonary embolism in the follow-up period. A diagnostic strategy for the evaluation of patients with suspected DVT based on pretest probability and d-dimer is safe and feasible in the emergency department setting...
  37. ncbi Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited. Results of a prospective study
    Erwin Stolz
    Dept of Neurology, Justus Liebig University, Am Steg 14, 35385 Giessen, Germany
    J Neurol 254:729-34. 2007
    Several case reports have linked iron deficiency anemia with the occurrence of cerebral venous thrombosis (CVT) or stroke, yet, it is unclear whether this is a chance association.
  38. ncbi Transcatheter arterial chemoembolization vs. chemoinfusion for unresectable hepatocellular carcinoma in patients with major portal vein thrombosis
    J H Kim
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Aliment Pharmacol Ther 29:1291-8. 2009
    ..Transcatheter arterial chemoinfusion (TACI) has been an option in such cases...
  39. pmc Individual participant data meta-analyses should not ignore clustering
    Ghada Abo-Zaid
    European Centre for Environment and Human Health, Peninsula College of Medicine and Dentistry, University of Exeter, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall TR1 3HD, UK
    J Clin Epidemiol 66:865-873.e4. 2013
    ..Individual participant data (IPD) meta-analyses often analyze their IPD as if coming from a single study. We compare this approach with analyses that rather account for clustering of patients within studies...
  40. ncbi Warfarin is safe as secondary prophylaxis in patients with cancer and a previous episode of venous thrombosis
    R D Bona
    St Francis Hospital and Medical Center, Hartford, Connecticut, USA
    Am J Clin Oncol 23:71-3. 2000
    ..of this study was to establish the safety and efficacy of sodium warfarin in the secondary prophylaxis of venous thrombosis in patients with cancer...
  41. ncbi Epidemiology of cancer-associated venous thrombosis
    Jasmijn F Timp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 122:1712-23. 2013
    Cancer-associated venous thrombosis is a common condition, although the reported incidence varies widely between studies depending on patient population, start and duration of follow-up, and the method of detecting and reporting ..
  42. ncbi Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study
    Michael D Kappelman
    Department of Pediatrics, Division of Paediatric Gastroenterology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Gut 60:937-43. 2011
    ..Recommendations for venous thromboembolism (VTE) prophylaxis in patients with inflammatory bowel disease (IBD) can be refined by incorporating patient-specific risk factors...
  43. ncbi Portal vein thrombosis and survival in patients with cirrhosis
    Michael J Englesbe
    Division of Transplantation, Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Liver Transpl 16:83-90. 2010
    ..39; 95% CI, 2.39-22.83). In conclusion, patients with cirrhosis complicated by PVT have an increased risk of death...
  44. ncbi Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, USA
    Am J Med 117:19-25. 2004
    ..To determine the incidence of deep vein thrombosis and pulmonary embolism in two cohorts representing regions of the United States...
  45. ncbi Comparison of outcomes after hospitalization for deep venous thrombosis or pulmonary embolism
    Susan Murin
    Thromb Haemost 88:407-14. 2002
    b>Venous thrombosis and pulmonary embolism are commonly viewed as different manifestations of a single disease process, venous thromboembolism...
  46. pmc Cell adhesion molecule 1: a novel risk factor for venous thrombosis
    Sandra J Hasstedt
    Department of Human Genetics, University of Utah, Salt Lake City, USA
    Blood 114:3084-91. 2009
    Protein C (PC) deficiency increases the risk of venous thrombosis (VT) among members of Kindred Vermont II but fails to fully account for the inheritance pattern...
  47. ncbi Risk factors for post-thrombotic syndrome in patients with a first deep venous thrombosis
    L W Tick
    Department of Internal Medicine, Meander Medical Center, Amersfoort, The Netherlands
    J Thromb Haemost 6:2075-81. 2008
    Post-thrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT).
  48. ncbi Inflammation in deep vein thrombosis and the development of post-thrombotic syndrome: a prospective study
    E M Roumen-Klappe
    Department of General Internal Medicine, Radbound University Nijmegen Medical Centre, and Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    J Thromb Haemost 7:582-7. 2009
    ....
  49. ncbi Portomesenteric venous thrombosis after laparoscopic surgery: a systematic literature review
    Aaron W James
    Department of Surgery, University of California, San Francisco, San Francisco, CA 94143 0790, USA
    Arch Surg 144:520-6. 2009
    Portomesenteric venous thrombosis (PVT) is an uncommon but potentially lethal condition reported after several laparoscopic procedures...
  50. ncbi Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model
    Sabine Eichinger
    Department of Internal Medicine I, the Karl Landsteiner Institut für Klinische Thromboseforschung, Wien, Austria
    Circulation 121:1630-6. 2010
    ..Predicting the risk of recurrent venous thromboembolism (VTE) in an individual patient is often not feasible. We aimed to develop a simple risk assessment model that improves prediction of the recurrence risk...
  51. ncbi Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study
    Trevor Baglin
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Lancet 362:523-6. 2003
    ..We aimed to determine the incidence of recurrence of VTE in relation to clinical risk factors and standard laboratory testing for heritable thrombophilic defects...
  52. ncbi Genetics of venous thrombosis
    F R Rosendaal
    Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 7:301-4. 2009
    b>Venous thrombosis (deep vein thrombosis, pulmonary embolism) is a common and serious disorder, with genetic and acquired risk factors. The genetic risk factors can be subdivided in to those that are strong, moderate and weak...
  53. ncbi Risk factors for venous thromboembolism in hospitalized patients with acute medical illness: analysis of the MEDENOX Study
    Raza Alikhan
    Academic Department of Surgery, Guy s, King s, and St Thomas School of Medicine, London, England
    Arch Intern Med 164:963-8. 2004
    ..There is limited information about risk factors for venous thromboembolism (VTE) in acutely ill hospitalized general medical patients...
  54. pmc A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1
    Pierre Emmanuel Morange
    INSERM, UMR_S 626, Universite de la Mediterranee, Marseille, F 13385 France
    Am J Hum Genet 86:592-5. 2010
    To identify genetic susceptibility factors conferring increased risk of venous thrombosis (VT), we conducted a multistage study, following results of a previously published GWAS that failed to detect loci for developing VT...
  55. ncbi Incidence of deep venous thrombosis after temporary joint spanning external fixation for complex lower extremity injuries
    Stephen Andrew Sems
    Department of Orthopaedic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Trauma 66:1164-6. 2009
    The purpose of this study was to determine the incidence of deep venous thrombosis (DVT) in a prospective protocol of early spanning external fixation with the concurrent use of low-molecular weight heparin (LMWH) in patients with high-..
  56. ncbi Prevention and treatment of postphlebitic syndrome: results of a 3-part study
    J S Ginsberg
    Department of Medicine, McMaster University Medical Center, 1200 Main St W, HSC-3W11, Hamilton, Ontario, Canada L8N 3Z5
    Arch Intern Med 161:2105-9. 2001
    BACKGROUND: The true incidence of postphlebitic syndrome (PPS) following proximal deep venous thrombosis (DVT) and the efficacy of graduated compression stockings in preventing and treating PPS are unknown...
  57. ncbi von Willebrand factor and its propeptide: the influence of secretion and clearance on protein levels and the risk of venous thrombosis
    A Y Nossent
    Hematology, Hemostasis and Thrombosis Research Center, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 4:2556-62. 2006
    ..VWF is secreted in equimolar amounts with its propeptide, which has a shorter half-life. VWF propeptide can be used as a measure of VWF secretion and allows estimation of the VWF half-life...
  58. ncbi Secondary prevention of venous thromboembolism with the oral direct thrombin inhibitor ximelagatran
    Sam Schulman
    Coagulation Unit, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    N Engl J Med 349:1713-21. 2003
    ..For many patients with venous thromboembolism, secondary prevention with vitamin K antagonists is not extended beyond six months, since the risk of recurrence may be outweighed by the risk of major bleeding...
  59. ncbi Cancer and venous thromboembolism
    Paolo Prandoni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua, Padua, Italy
    Lancet Oncol 6:401-10. 2005
    ..However, the issue of whether screening for occult malignant disease ultimately improves prognosis and survival remains to be resolved...
  60. ncbi Deep-vein thrombosis rates after major orthopedic surgery in Asia. An epidemiological study based on postoperative screening with centrally adjudicated bilateral venography
    F Piovella
    UO Malattie Tromboemboliche, Sevizio Malattie Tromboemboliche, IRCCS Policlinico San Matteo, Pavia, Italy
    J Thromb Haemost 3:2664-70. 2005
    ..The incidence of postsurgical venous thromboembolism is thought to be low in Asian ethnic populations...
  61. ncbi Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Ann Intern Med 149:698-707. 2008
    The reason some patients with deep venous thrombosis (DVT) develop the postthrombotic syndrome is not well understood.
  62. ncbi Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review
    M Di Nisio
    Department of Medicine and Aging, School of Medicine, and Aging Research Centre, Ce S I, Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
    J Thromb Haemost 5:296-304. 2007
    ..It is unknown to what extent this is due to differences in study design or patient groups, or to genuine differences between D-dimer assays...
  63. ncbi The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients
    Paolo Prandoni
    Department of Medical and Surgical Sciences, University of Padua, Via Ospedale Civile 105, 35128, Padua, Italy
    Haematologica 92:199-205. 2007
    ..The aim of this investigation was to assess the rate of recurrent VTE after withdrawal of vitamin K antagonists, and to identify clinical parameters associated with a higher likelihood of recurrence...
  64. ncbi Clinical predictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism: findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry
    Silvy Laporte
    Clinical Pharmacology Department, Thrombosis Research Group, EA 3065, University Hospital of Saint Etienne Bellevue, 42055 Saint Etienne Cedex 02, France
    Circulation 117:1711-6. 2008
    ..Clinical predictors for fatal pulmonary embolism (PE) in patients with venous thromboembolism have never been studied...
  65. ncbi Incidence of thrombotic complications in patients with haematological malignancies with central venous catheters: a prospective multicentre study
    Agostino Cortelezzi
    Department of Haematology and Bone Marrow Transplantation Unit, IRCCS Fondazione Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
    Br J Haematol 129:811-7. 2005
    ..This study shows that the impact on clinical practice of symptomatic CVC-related thrombotic complications is not negligible in patients with haematological malignancies...
  66. ncbi The challenge of diagnosing pulmonary embolism in elderly patients: influence of age on commonly used diagnostic tests and strategies
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Am Geriatr Soc 53:1039-45. 2005
    ..Therefore, a rational diagnostic approach to PE in older people should rest mainly on the sequential use of those tests that have demonstrated strong diagnostic yield, accuracy, and safety in this population...
  67. pmc Epidemiology and risk factors for venous thrombosis
    Mary Cushman
    Department of Medicine, Thrombosis and Hemostasis Program, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, VT, USA
    Semin Hematol 44:62-9. 2007
    b>Venous thrombosis, including deep vein thrombosis (DVT) and pulmonary embolism (PE), occurs at an annual incidence of about 1 per 1,000 adults...
  68. pmc The impact of venous thromboembolism on risk of death or hemorrhage in older cancer patients
    Cary P Gross
    Section of General Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Gen Intern Med 22:321-6. 2007
    ..Among older cancer patients, there is uncertainty about the degree to which venous thromboembolism (VTE) and its treatment increase the risk of death or major hemorrhage...
  69. ncbi Pilot clinical trial of localized concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma with portal vein thrombosis
    Kwang Hyub Han
    Department of Internal Medicine, Yonsei Liver Cancer Special Clinic, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Cancer 113:995-1003. 2008
    ..The objective of the current study was to evaluate the therapeutic effect of localized CCRT followed by HAIC as a new treatment modality for these patients...
  70. ncbi The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis: a report on 241 cases
    Jean Jacques Kiladjian
    Assistance Publique Hopitaux de Paris, Hopital Avicenne, Service d Hematologie Clinique, and Université Paris 13, Bobigny, France
    Blood 111:4922-9. 2008
    ..Underlying MPD is associated with severe forms of BCS, but current therapy appears to offset deleterious effects of MPD on the medium-term outcome...
  71. ncbi Serial 2-point ultrasonography plus D-dimer vs whole-leg color-coded Doppler ultrasonography for diagnosing suspected symptomatic deep vein thrombosis: a randomized controlled trial
    Enrico Bernardi
    Department of Emergency and Accident Medicine, Civic Hospital, Conegliano, Italy
    JAMA 300:1653-9. 2008
    ..No randomized comparisons are yet available evaluating the relative values of these 2 strategies...
  72. ncbi The role of timing of tourniquet release and cementing on perioperative blood loss in total knee replacement
    Anastasios G Christodoulou
    Department of Orthopaedics, Hippokration General Hospital, Thessaloniki, 58, J Kennedy St, Pilea 55535, Greece
    Knee 11:313-7. 2004
    ..Postoperative tourniquet release seems to offer better conditions of haemostasis probably due to the better controlled fibrolytic activity...
  73. ncbi Predictors of the post-thrombotic syndrome during long-term treatment of proximal deep vein thrombosis
    S R Kahn
    McGill University, Montreal, Quebec, Canada
    J Thromb Haemost 3:718-23. 2005
    The post-thrombotic syndrome is a chronic, poorly understood complication of deep venous thrombosis (DVT).
  74. ncbi Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement
    B I Eriksson
    Sahlgrenska University HospitalOstra, Gothenburg, Sweden
    J Thromb Haemost 4:121-8. 2006
    ..Joint replacement surgery is an appropriate model for dose-ranging studies investigating new anticoagulants...
  75. ncbi Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence
    A N Nicolaides
    Int Angiol 24:1-26. 2005
    ..The aim of this document is to provide guidelines for investigation and management of patients with thrombophilia in the presence or absence of venous thromboembolism (VTE)...
  76. ncbi Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. Warfarin Optimal Duration Italian Trial Investigators
    G Agnelli
    Dipartimento di Medicina Interna, Universita di Perugia, Italy
    N Engl J Med 345:165-9. 2001
    In patients with idiopathic deep venous thrombosis, continuing anticoagulant therapy beyond three months is associated with a reduced incidence of recurrent thrombosis during the period of therapy...
  77. ncbi Epidemiology, risk and prognostic factors in mesenteric venous thrombosis
    S Acosta
    Vascular Centre, Malmo University Hospital, Malmo, Sweden
    Br J Surg 95:1245-51. 2008
    Epidemiological reports on risk and prognostic factors in patients with mesenteric venous thrombosis (MVT) are scarce.
  78. ncbi Single center experience of 39 patients with preoperative portal vein thrombosis among 404 adult living donor liver transplantations
    Hiroto Egawa
    Organ Transplant Unit, Department of Transplant Surgery, Kyoto University Hospital, Kyoto, Japan
    Liver Transpl 12:1512-8. 2006
    ..Three out of 10 patients with residual PVT required radiological and/or surgical intervention after transplantation. In conclusion, thorough planning is essential for a successful LDLT outcome for patients with preexisting PVT...
  79. pmc Selection criteria for hepatectomy in patients with hepatocellular carcinoma and portal vein tumor thrombus
    M Minagawa
    Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Ann Surg 233:379-84. 2001
    ....
  80. ncbi Venous thromboembolism after acute stroke
    J Kelly
    Elderly Care Department, St. Thomas' Hospital, London, England
    Stroke 32:262-7. 2001
    ....
  81. ncbi Venous thromboembolism prophylaxis in acutely ill hospitalized medical patients: findings from the International Medical Prevention Registry on Venous Thromboembolism
    Victor F Tapson
    Division of Pulmonary and Critical Care, Box 31175, Room 351 Bell Building, Duke University Medical Center, Durham, NC 27710, USA
    Chest 132:936-45. 2007
    ..Our aim was to characterize the clinical practices for VTE prophylaxis in acutely ill hospitalized medical patients enrolled in the International Medical Prevention Registry on Venous Thromboembolism (IMPROVE)...
  82. ncbi Thrombophilia, clinical factors, and recurrent venous thrombotic events
    Sverre C Christiansen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:2352-61. 2005
    ..The potential benefit of screening for thrombophilia with respect to prophylactic strategies and duration of anticoagulant treatment is not yet known...
  83. ncbi Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis
    I Pabinger
    Department of Internal Medicine I, Division of Haematology and Blood Coagulation, Medical University, Vienna, Austria
    J Thromb Haemost 3:949-54. 2005
    ..Limited data exist on the risk of pregnancy-associated venous thromboembolism (VTE) in women with a history of VTE...
  84. ncbi Deep venous thrombosis prophylaxis: are guidelines being followed?
    Hairul A Ahmad
    Alfred Hospital, Melbourne, Victoria, Australia
    ANZ J Surg 72:331-4. 2002
    The purposes of the present study were to determine whether patients in The Canberra Hospital are receiving appropriate Deep Venous Thrombosis (DVT) prophylaxis, and to ascertain the awareness of appropriate treatment by clinicians.
  85. ncbi D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis. A pilot study
    John E Rectenwald
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Thromb Haemost 94:1312-7. 2005
    Current plasma markers for diagnosis of deep venous thrombosis (DVT) allow for exclusion of the diagnosis, but lack adequate specificity to establish the diagnosis...
  86. ncbi High levels of coagulation factor XI as a risk factor for venous thrombosis
    J C Meijers
    Department of Hematology, University Medical Center, and Institute of Biomembranes, Utrecht University, The Netherlands
    N Engl J Med 342:696-701. 2000
    ..A deficiency of factor XI is associated with bleeding, but a role of high factor XI levels in thrombosis has not been investigated...
  87. ncbi Survival analysis of 904 patients with hepatocellular carcinoma in a hepatitis B virus-endemic area
    Kyung Woo Park
    Center for Liver Cancer, National Cancer Center, Goyang, Republic of Korea
    J Gastroenterol Hepatol 23:467-73. 2008
    ..To investigate the clinical characteristics and survival outcomes of a large cohort of hepatocellular carcinoma (HCC) patients treated at a single institute in a hepatitis B virus (HBV)-endemic area...
  88. ncbi Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study
    E R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:632-7. 2008
    b>Venous thrombosis is one of the leading causes of maternal morbidity and mortality.
  89. ncbi Missed opportunities for prevention of venous thromboembolism: an evaluation of the use of thromboprophylaxis guidelines
    D M Arnold
    Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Canada
    Chest 120:1964-71. 2001
    ..Inadequacy of prophylaxis was most often caused by omission of prophylaxis. Missed opportunities for prevention occurred most commonly in the settings of nonorthopedic surgery, pneumonia, and stroke...
  90. ncbi Measurement properties of the Villalta scale to define and classify the severity of the post-thrombotic syndrome
    S R Kahn
    Division of Internal Medicine and Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, McGill University, Montreal, Canada
    J Thromb Haemost 7:884-8. 2009
    The post-thrombotic syndrome (PTS) is a frequent and important complication of deep venous thrombosis (DVT). The diagnosis of PTS is based primarily on the presence of typical symptoms and clinical signs...
  91. pmc The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study
    A Van Hylckama Vlieg
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 P, PO Box 9600, NL 2300 RC Leiden, Netherlands
    BMJ 339:b2921. 2009
    ..To assess the thrombotic risk associated with oral contraceptive use with a focus on dose of oestrogen and type of progestogen of oral contraceptives available in the Netherlands...
  92. ncbi Short-term natural history of isolated gastrocnemius and soleal vein thrombosis
    P S Macdonald
    Department of Surgery, McGill University, Montreal, Quebec, Canada
    J Vasc Surg 37:523-7. 2003
    ..The purpose of this study was to establish the incidence rate of propagation of isolated gastrocnemius and soleal vein thrombosis (IGSVT) into the deep veins of the calf and thigh...
  93. pmc Third generation oral contraceptives and risk of venous thrombosis: meta-analysis
    J M Kemmeren
    Julius Centre for General Practice and Patient Oriented Research, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, Netherlands
    BMJ 323:131-4. 2001
    ..quantitatively articles that compared effects of second and third generation oral contraceptives on risk of venous thrombosis. DESIGN: Meta-analysis...
  94. ncbi Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7)
    Iwona Kucharewicz
    Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland
    Hypertension 40:774-9. 2002
    ..Intravenous infusion of Ang-(1-7) (1, 10, or 100 pmol/kg per minute for 2 hours) into rats developing venous thrombosis caused 50% to 70% reduction of the thrombus weight...
  95. ncbi Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, University of Milano, Italy
    Circulation 110:566-70. 2004
    ..Risk factors for primary upper-extremity DVT are not well established, and the recurrence rate is unknown...
  96. ncbi Cost-effectiveness of ruling out deep venous thrombosis in primary care versus care as usual
    A J Ten Cate-Hoek
    Department of Clinical Epidemiology, Maastricht University Medical Center, Maastricht, The Netherlands
    J Thromb Haemost 7:2042-9. 2009
    ..Referral for ultrasound testing in all patients suspected of DVT is inefficient, because 80-90% have no DVT...
  97. ncbi Gene variants associated with deep vein thrombosis
    Irene D Bezemer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 299:1306-14. 2008
    ..The genetic causes of deep vein thrombosis (DVT) are not fully understood...
  98. ncbi Withholding anticoagulation after a negative result on duplex ultrasonography for suspected symptomatic deep venous thrombosis
    Scott M Stevens
    LDS Hospital and University of Utah, Salt Lake City, Utah 84143, USA
    Ann Intern Med 140:985-91. 2004
    Negative results on simplified compression ultrasonography cannot rule out symptomatic deep venous thrombosis (DVT) without further testing, such as repeated ultrasonography several days later...
  99. ncbi Portal vein thrombosis
    Sameer Parikh
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Med 123:111-9. 2010
    ..This review conflates dissenting views into a rational approach of managing patients with portal vein thrombosis for the general internist...
  100. ncbi APC resistance: biological basis and acquired influences
    E Castoldi
    Department of Biochemistry, Maastricht University, Maastricht, The Netherlands
    J Thromb Haemost 8:445-53. 2010
    ..APC (APC resistance), are prevalent in the general population and are associated with an increased risk of venous thrombosis. APC resistance was originally discovered in thrombophilic families and later shown to be associated with ..

Research Grants78

  1. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  2. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2012
    ..The proposed research on novel dual direct inhibitors of thrombin and factor Xa aims to improve current anticoagulation therapy, which is beset with significant number of adverse reactions and limitations. ..
  3. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
    ..is important for health, whereas low B6 status is associated with increased risk of cardiovascular disease, venous thrombosis and stroke...
  4. STRUCTURE AND FUNCTION OF HEPARIN COFACTOR II
    Douglas M Tollefsen; Fiscal Year: 2010
    ..heparin or DS to determine the importance of HCII-glycosaminoglycan interactions in models of arterial and venous thrombosis. Immunohistochemical methods will be used to localize HCII and glycosaminoglycans in the vessel wall after ..
  5. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    ..Dosimetry estimates will be performed on optimized probes and the most promising will be evaluated for acute toxicity. The output of this research will be a novel thrombus imaging probe that may be subsequently developed for human use. ..
  6. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
    ..S. patients each year. Primary APS in some severe cases leads to death via emergency venous thrombosis/embolism;and secondary APS compounds other autoimmune diseases such as lupus and venous thromboembolism...
  7. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
    ..The objectives of this basic research proposal are therefore of direct relevance to a serious condition that impacts the health of the warfighter, the military family, and the American public. ..
  8. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..According to the Surgeon General's 2008 Call to Action to Prevent Deep Venous Thrombosis and Pulmonary Embolism, over 300,000 Americans each year suffer from venous thromboembolism (VTE), with ..
  9. Chemopreventative properties of Medicinal and Food plants of the Lumbee Tribe
    TRACIE LOCKLEAR; Fiscal Year: 2010
    ..The long-term goals of the project are the development of new and novel natural agents for the chemoprevention of breast cancer. Data generated from the proposed work will be used to further investigations in animal and human studies. ..
  10. Structural and Biochemical Basis of the Vitamin K cycle
    Weikai Li; Fiscal Year: 2013
    ..Future research in my group will use a combination of X-ray crystallography, protein biochemistry, and cell biology. My long-term goal is to understand the entire vitamin K pathway that sustains blood coagulation. ..
  11. Physiology and Molecular Biology of Factor XI
    David Gailani; Fiscal Year: 2013
    ..role in hemostasis, a variety of data now make a compelling case that fXI contributes to arterial and venous thrombosis and is, therefore, an attractive candidate for targeted therapy to treat or prevent thromboembolic disease...
  12. Novel Molecules in Calcium Signaling in Platelets
    Wolfgang Bergmeier; Fiscal Year: 2013
    ..is relevant in vivo when thrombus formation is driven by thrombin under low shear conditions, such as in venous thrombosis models. We have strong preliminary data supporting each of the above specific aims...
  13. High throughput assay for fibrin-binding probes
    PETER D CARAVAN; Fiscal Year: 2013
    ....
  14. Fibrotic effects and regulation of MMP proteins in thrombus resolution
    Rajabrata Sarkar; Fiscal Year: 2009
    Deep venous thrombosis (DVT) affects more than 2 million Americans per year. Post-phlebitic syndrome can affect 25-75% of patients following DVT and includes leg swelling, pain, skin changes and ulceration of the skin...
  15. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy
    Everette C Burdette; Fiscal Year: 2012
    ..e., atelectasis and pneumonia, deep venous thrombosis and pulmonary embolism...
  16. Genetic and Environmental Risk Factors for Venous Thromboembolism
    Christopher Kabrhel; Fiscal Year: 2013
    ..Our analyses will result in identification of novel common genetic loci for VTE. Given the high population prevalence of risk factors and the high mortality of VTE, the potential public health impact of this work is large. ..
  17. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul E Bock; Fiscal Year: 2010
    Factor V plays a pivotal role in hemostasis, and in the pathology of venous thrombosis. Fluorescence-based equilibrium binding, steady-state and rapid reaction kinetics are proposed to define the molecular mechanisms of the procoagulant ..
  18. Association of TFPI with antemortem dementia and postmortem micro brain infarcts
    SUSAN ANTONE MARONEY; Fiscal Year: 2013
    ..Finally, other risk factors of cardiovascular disease found within the BioLINCC database will be used in a linear regression model to determine the significance of TFPI and PS on the pathogenesis of dementia. ..
  19. Factor XI inhibitor for thrombosis
    ERIK IAN TUCKER; Fiscal Year: 2013
    ..antibody against coagulation factor XI (AXIMAB 1A6) for the safe prevention and treatment of acute venous thrombosis. We have reached our Phase I milestones: 1) Establishing a minimum saturating dose of 1A6 (0...
  20. Serpin Regulation of Coagulation Proteases
    Alireza R Rezaie; Fiscal Year: 2013
    ..lining the microvasculature or therapeutically administered for prophylaxis and treatment of venous thrombosis. In addition to its anticoagulant function through the direct inhibition of procoagulant coagulation ..
  21. Novel Methods for Dissolving Blood Clots
    GUY LELAND REED; Fiscal Year: 2013
    ..VTEs are blood clots in the legs (venous thrombosis) that may travel to the lungs (pulmonary embolism)...
  22. Identifying novel genetic risk factors for venous thromboembolism (VTE)
    Jun Li; Fiscal Year: 2013
    ..The results should significantly advance our understanding of the genetic basis of VTE pathogenesis and enhance our capacity to identify patients at high risk for VTE. ..
  23. Mechanisms of Venous Thromboembolism in Cancer
    Nigel Mackman; Fiscal Year: 2012
    ..whether an association exists between tissue factor (TF) activity in circulating microparticles (MPs) and venous thrombosis in patients with pancreatic or colon cancer, and in tumor-bearing mice...
  24. Clinical Trial Planning Grant in Catheter-Directed Thrombolysis of Occlusive DVT
    Marilyn J Manco-Johnson; Fiscal Year: 2013
    ..by applicant): In 2008, the United States (US) Surgeon General's Call-to-Action on Prevention of Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE) emphasized chronic venous insufficiency following DVT as an important ..
  25. Cardiovascular Inflammation Reduction Trial (CIRT): DCC
    Robert J Glynn; Fiscal Year: 2013
    ..Secondary endpoints include diabetes, venous thrombosis, and atrial fibrillation, all of which have an inflammatory basis...
  26. Cardiovascular Inflammation Reduction Trial (CIRT)
    Paul M Ridker; Fiscal Year: 2013
    ..Secondary endpoints include diabetes, venous thrombosis, and atrial fibrillation, all of which have an inflammatory basis...
  27. BIOSYNTHESIS OF MEMBRANE PROTEIN GLYCOLIPID ANCHORS
    Anant K Menon; Fiscal Year: 2010
    ..The latter include an inherited GPI deficiency characterized by venous thrombosis and seizures, and paroxysmal nocturnal hemoglobinuria (PNH), an acquired hemolytic disease that is caused by ..
  28. NETs in the development of lupus and its cardiovascular complications
    Daniel T Eitzman; Fiscal Year: 2013
    ..Our data are supported by recent studies also linking NETosis to idiopathic atherosclerosis and to venous thrombosis. This competing renewal application will determine the in vivo importance of aberrant NETosis in CV damage ..
  29. Antithrombotic Aptamers and Antidotes
    BRUCE ALAN SULLENGER; Fiscal Year: 2013
    ..We believe the generation of such antidote controllable therapeutic agents will lead to safer treatment of a number of cardiovascular disorders and improve the overall health and welfare of the public. ..
  30. Anatomic Risk Factors for Venous Thromboembolism
    ANAND KUMAR NARAYAN; Fiscal Year: 2010
    Deep venous thrombosis (DVT) of the lower extremity is one of the major causes of morbidity and mortality in hospital based patients...
  31. Novel Micro-Implant to Measure Intracardiac Pressure in Congenital Heart Patients
    Nader Najafi; Fiscal Year: 2013
    ..of the hemi- Fontan pathway during the immediate post-operative period without the risk of systemic venous thrombosis. Interval testing of the hemi-Fontan pathway pressure in the ambulatory setting will allow clinicians to ..
  32. Microvesicle production after trauma &its Clinical Impact on Venothromboembolism
    Myung S Park; Fiscal Year: 2013
    ..Almost a third of the patients with this clotting abnormality die as a result of this. More research needs to be done to better diagnose and prevent this complication. ..
  33. Sensitive Measurement of Cardiac Troponin I at Point of Care: The Silicon BioDevi
    OCTAVIAN FLORESCU; Fiscal Year: 2012
    ..In this project we demonstrate a microchip-based assay platform that performs assays with laboratory precision and a one-step protocol and which can be mass- produced using existing foundry capacity. ..
  34. Deep Vein Thrombosis and Chronic Thrombotic Venous Disease
    Timothy A Morris; Fiscal Year: 2012
    ..If left untreated, this condition can cause chronic leg pain and disfigurement. Our goal is to understand the mechanisms responsible for the development of CTVD in some patients after acute deep vein thrombosis. ..
  35. Stroke and aPL: Community-Based Clinicopathological Study
    STEVEN RICHARD LEVINE; Fiscal Year: 2012
    ..that found a single positive baseline aPL to be an independent risk factor for: (a) venous blood clots (deep venous thrombosis and pulmonary embolism) in men (Physicians Health Study) (Ginsburg et al 1992), (b) MI and stroke in men (..
  36. Platelet adhesion to neutrophil extracellular DNA traps: role in thrombosis
    Denisa D Wagner; Fiscal Year: 2013
    ..We hope that our studies will broaden understanding of the thrombotic process in general and that we may uncover new molecular targets to treat pathological thrombosis. ..
  37. The Incidence and Progression of Peripheral Venous Disease
    Michael H Criqui; Fiscal Year: 2010
    ..We will separately determine the incidence of venous thrombosis and pulmonary embolism...
  38. Ultrasound assisted thrombolysis for acute pulmonary embolism
    CURTIS GENSTLER; Fiscal Year: 2012
    ..At the end of therapy, time to lysis determined angiographically will be used to determine bioefficacy. ..
  39. Griffin: Venous Thromboembolism and mass spectrometry-based untargeted metabolomi
    JOHN H contact GRIFFIN; Fiscal Year: 2010
    ..To discover new biomarkers for risk of VTE, we will screen >3,500 metabolites normally found in blood plasma from approximately 1,000 VTE subjects using pioneering state-of-the-art mass spectrometry based technologies. ..
  40. Characterization of coagulation factor-platelet interactions: role of FXI
    Owen J McCarty; Fiscal Year: 2013
    ..We propose that elucidation of the role that FXI plays in clot formation may provide the basis for the pharmaceutical development of such a novel class of FXI-targeted anti-thrombotics. ..
  41. Blood Transfusions: Gender Differences in Utilization, Predictors, and Outcomes
    Mary A M Rogers; Fiscal Year: 2010
    ....
  42. EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISM
    Aaron R Folsom; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Venous thromboembolism (VTE), comprising deep venous thrombosis and pulmonary embolism, is a major contributor to morbidity and mortality in the U.S...
  43. Predictive optimal anticlotting treatment for segmented patient populations
    Peter J Tonellato; Fiscal Year: 2013
    ..Such predictive evidence can then be used to guide clinical trial designs, and suggest improvements to hospital-wide anticlotting treatment plans. ..
  44. Hemostatic factors and sickle cell disease
    Punam Malik; Fiscal Year: 2013
    ..to both physiological hemostasis and pathological vaso-occlusive events, including myocardial infarction, venous thrombosis and stroke...
  45. Microparticle Docking in Pancreatic Cancer Induced VTE
    Julia E Geddings; Fiscal Year: 2013
    ..I hypothesize that tumor-derived MPs (TMPs) trigger venous thrombosis by delivering tissue factor to the vessel wall via specific ligand-receptor interactions...
  46. p16INK4a, Senescence and Aging in Venous Thromboembolism
    FRANK CHURCH; Fiscal Year: 2009
    ..Independent of other risk factors, increasing age is linked to an increase in venous thrombosis and venous thromboembolism...
  47. ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MAN
    Ronald J Falk; Fiscal Year: 2013
    ..discovery of anti-plamsinogen antibodies while studying autoantigen complementarity, we will determine If venous thrombosis in ANCA disease patients is attributable to these antibodies...
  48. Infection and Inflammation in Pediatric Catheter Related Venous Thrombosis
    Leslie J Raffini; Fiscal Year: 2012
    ..End of Abstract) ..
  49. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
    ....
  50. Circulating Age-related Lipid Mediators in Thrombosis
    Thomas M McIntyre; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Aging is associated with an increased risk of venous thrombosis, but we do not understand the factors that connect aging to an increasing propensity for pathologic thrombotic events...
  51. Novel Therapeutic Targets for Venous Thromboembolism
    THOMAS WILLIAM WAKEFIELD; Fiscal Year: 2012
    ..The current proposal addresses the role of VWF and P-selectin in basic studies in rodent models of venous thrombosis, evaluates new aptamer inhibitors to VWF and P-selectin in a well established primate model of iliac vein ..
  52. DEVELOPMENT OF A FIRST-IN-CLASS TARGETED FIBRINOLYTIC FOR POST-SURGICAL THROMBOPR
    Ronald Carnemolla; Fiscal Year: 2013
    ..Funding for further development will be pursued through grants, such as SBIR/STTR &advocacy groups (National Blood Clot Alliance, AHA), and solicitation of equity investments. ..
  53. The Thrombin-Thrombomodulin Interaction
    Elizabeth A Komives; Fiscal Year: 2012
    ..occlude the flow of blood through blood vessels resulting in heart attacks, strokes, pulmonary emboli, and venous thrombosis. These diseases are the most common causes of mortality in the US...
  54. Mechanism of Thrombosis in Heparin Induced Thrombocytopenia
    RAJ SUNDAR KASTHURI; Fiscal Year: 2013
    ..despite a decrease in platelet count, the most feared complication of HIT is the development of arterial and venous thrombosis, the pathophysiological mechanism of which is poorly understood...
  55. Tissue factor expression in HIV disease - Implications for cardiovascular risk
    Nicholas Funderburg; Fiscal Year: 2013
    ..Human immunodeficiency virus (HIV) infection is associated with an increased risk of both arterial and venous thrombosis, and as highly active antiretroviral therapy (HAART) is increasing the expected lifespan of HIV/AIDS ..
  56. 2010 Gordon Research Conference on Plasminogen Activation and Ertracellular Prote
    Bradford S Schwartz; Fiscal Year: 2010
    ..The conference will bring together the leading researchers in the world to discuss their latest research in this area, with the goal of translating these discoveries into new and better treatment of human disease. ..
  57. Platelet Microvesicles
    Perumal Thiagarajan; Fiscal Year: 2013
    ..Increased microvesicles have been detected in conditions associated with either arterial or venous thrombosis. These associations suggest that, while they may be necessary for normal hemostasis, elevated microvesicles ..
  58. Adverse Events Associated with Testosterone Treatment in Hypogonadal Men
    THOMAS JAMES WALSH; Fiscal Year: 2013
    ..be combined cardiovascular (CV) events (recurrent and incident myocardial infarction, ischemic stroke, and venous thrombosis) and incident aggressive prostate cancer (Gleason grade >8 or PSA >20 ng/dl or T3 stage or greater or ..
  59. Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism
    Kyongtae T Bae; Fiscal Year: 2012
    ..We believe the proposed study is timely and will provide a new insight to prognosis and clinical management and treatment of PE. ..
  60. Mechanisms for Blood Cell Adhesion Under Flow
    RODGER PAUL MCEVER; Fiscal Year: 2012
    ..This information obtained may offer new methods to treat excessive blood cell adhesion in heart attacks, strokes, deep venous thrombosis, and other disorders.
  61. REGULATION OF PLATELET AND ENDOTHELIAL CELL FUNCTION
    Joel S Bennett; Fiscal Year: 2012
    ..hemostasis plays an important role in the pathogenesis of atherosclerotic vascular disease and arterial and venous thrombosis. Essential features of hemostatic regulation are control of the interplay between circulating platelets and ..
  62. Does screening variability make DVT an unreliable quality measure of trauma care?
    Elliott R Haut; Fiscal Year: 2012
    ..Therefore, reported DVT rates are unreliable quality of care measures and should not be used to compare hospitals or for pay-for-performance initiatives. ..
  63. Long Circulating Low Molecular Weight Heparins Pulmonary
    Fakhrul Ahsan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  64. ENDOTHELIAL INJURY AND CYTOPROTECTION
    JACK HAWIGER; Fiscal Year: 1993
    ..seeding of fibrin thrombi on the vessel wall a process contributing to an estimated 5 million episodes of venous thrombosis and 1.5 million cases of acute coronary thrombosis per year in the United States...
  65. Venous thromboembolism among California cancer patients
    Helen Chew; Fiscal Year: 2003
    Venous thromboembolism (VTE, includes both venous thrombosis and pulmonary embolism) is a frequent complication among patients with cancer...
  66. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX II
    CHARLES HALES; Fiscal Year: 2003
    ..permit a strategy of management by treatment on the basis of venous thromboembolic disease (PE or deep venous thrombosis), ventilation/perfusion lung scan, or compression ultrasound of the lower extremities...
  67. Hip Fracture Evaluation Alternatives of Total Hip vs Hemi-arthroplasty (HEALTH)
    Thomas Einhorn; Fiscal Year: 2009
    ..Potential Impact: This trial will not only change current orthopaedic practice, but will set a benchmark for the conduct of future orthopaedic trials. ..
  68. HEMOSTATIC EFFECTS OF FIBRINOLYTIC THERAPY
    BARBARA ALEVRIADOU; Fiscal Year: 2000
    Fibrinolytic (thrombolytic) therapy has been used in treating arterial and venous thrombosis. Administration of thrombolytic agents, such as streptokinase, urokinase or tissue-type plasminogen activator (t-PA), is standard treatment for ..
  69. Integrated Multifunctional Imaging of Deep Vein Thrombosis
    Walter Scott; Fiscal Year: 2009
    Deep venous thrombosis (DVT), and its sequelae, pulmonary embolism (PE), is a significant clinical problem, representing the leading cause of preventable in-hospital mortality in the USA and other developed countries...
  70. Cost Effectiveness of Anticoagulation Versus Genetic Testing of CYP2C9 & VKORC1 G
    Anna Teschemaker; Fiscal Year: 2009
    ..be extrapolated with the criteria including patient age >18 years, confirmed clinical diagnosis of deep venous thrombosis or pulmonary embolism, warfarin therapy prescribed for at least 6 months, and an indication for target INR ..
  71. PROTEASE MODULATING WOUND DRESSINGS FOR THE TREATMENT OF VENOUS ULCERS
    DAVID VACHON; Fiscal Year: 2006
    ..of venous insufficiency, potentially leading to non-healing stasis ulcers, include varicose veins, deep venous thrombosis, neoplastic obstructions, and congenital or acquired arterio-venous fistulae...
  72. INFERIOR VENA CAVA FILTRATION WITH A REMOVABLE DEVICE
    Elvira Lang; Fiscal Year: 1999
    ..These are all patients who are at risk of developing deep venous thrombosis and subsequent pulmonary embolism...
  73. PROSPECTIVE INVESTIGATION OF PE DX-II
    Kenneth Leeper; Fiscal Year: 2003
    ..leg tests, particularly venous ultrasonography, permit a strategy of management by identifying deep venous venous thrombosis (DVT) and potentially obviating the need for pulmonary angiography...
  74. Antithrombotic Activity of Ascidian Glycosaminoglycans
    DOUGLAS TOLLEFSEN; Fiscal Year: 2004
    DESCRIPTION (provided by applicant) Heparin from porcine or bovine tissues is used to treat diseases such as venous thrombosis, pulmonary embolism, and coronary artery thrombosis...
  75. ORAL CONTRACEPTIVES AND THROMBOEMBOLIC DISEASE
    Stephen Sidney; Fiscal Year: 2000
    ..are to determine the following: a) the relative and attributable risk of venous thromboembolic disease (deep venous thrombosis and pulmonary embolism) in current users of low-dose (<50 micrograms estrogen) oral contraceptive (OC) ..
  76. Thrombin Formation Inhibitors
    James Phillips; Fiscal Year: 2004
    Deep venous thrombosis (DVT) is a blood clot that has formed in one of the large veins far below the skin and blocks normal blood flow back to the heart...
  77. Pharmacologic treatment of thromboembolism
    TZE CHEIN WUN; Fiscal Year: 2009
    ..Anticoagulants are pivotal agents in the prevention and treatment of arterial and venous thrombosis. The limitations of currently approved anticoagulant drugs have prompted the search for new anticoagulants ..
  78. Novel Recombinant Anticoagulant Proteins
    TZE CHEIN WUN; Fiscal Year: 2005
    ..This process will also lay a foundation for Phase II GLP production of the recombinant proteins. ..