thrombosis

Summary

Summary: Formation and development of a THROMBUS or blood clot in the blood vessel.

Top Publications

  1. doi Endothelial-derived microparticles: Biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis
    Aurelie S Leroyer
    Laboratoire de Physiopathologie de l Endothélium UMR_S 608 INSERM, Universite de la Mediterranee, Marseille, France
    Thromb Haemost 104:456-63. 2010
  2. ncbi Clinical end points in coronary stent trials: a case for standardized definitions
    Donald E Cutlip
    Harvard Clinical Research Institute, Harvard Medical School, 930 Commonwealth Avenue, Boston, MA 02215, USA
    Circulation 115:2344-51. 2007
  3. pmc Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Walter Ageno
    University of Insubria, Varese, Italy
    Chest 141:e44S-88S. 2012
  4. doi Thrombosis as an intravascular effector of innate immunity
    Bernd Engelmann
    Institut für Laboratoriumsmedizin, Klinikum der Universitat, Ludwig Maximilians Universitat, Marchioninistrasse 15, 81377 Munich, Germany
    Nat Rev Immunol 13:34-45. 2013
  5. pmc Microparticles in hemostasis and thrombosis
    A Phillip Owens
    Division of Hematology Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, North Carolina, USA
    Circ Res 108:1284-97. 2011
  6. pmc Platelets in inflammation and atherogenesis
    Meinrad Gawaz
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Clin Invest 115:3378-84. 2005
  7. ncbi The interactions between inflammation and coagulation
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Br J Haematol 131:417-30. 2005
  8. doi Cytochrome p-450 polymorphisms and response to clopidogrel
    Jessica L Mega
    Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 360:354-62. 2009
  9. doi A shear gradient-dependent platelet aggregation mechanism drives thrombus formation
    Warwick S Nesbitt
    The Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Educational Precinct, Melbourne, Victoria, Australia
    Nat Med 15:665-73. 2009
  10. pmc Extracellular DNA traps promote thrombosis
    Tobias A Fuchs
    Immune Disease Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:15880-5. 2010

Research Grants

Detail Information

Publications328 found, 100 shown here

  1. doi Endothelial-derived microparticles: Biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis
    Aurelie S Leroyer
    Laboratoire de Physiopathologie de l Endothélium UMR_S 608 INSERM, Universite de la Mediterranee, Marseille, France
    Thromb Haemost 104:456-63. 2010
    ..Moreover, in the future, it can open novel therapeutic perspectives based on the inhibition of EMP release...
  2. ncbi Clinical end points in coronary stent trials: a case for standardized definitions
    Donald E Cutlip
    Harvard Clinical Research Institute, Harvard Medical School, 930 Commonwealth Avenue, Boston, MA 02215, USA
    Circulation 115:2344-51. 2007
    ..Although most clinical trials of coronary stents have measured nominally identical safety and effectiveness end points, differences in definitions and timing of assessment have created confusion in interpretation...
  3. pmc Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Walter Ageno
    University of Insubria, Varese, Italy
    Chest 141:e44S-88S. 2012
    ....
  4. doi Thrombosis as an intravascular effector of innate immunity
    Bernd Engelmann
    Institut für Laboratoriumsmedizin, Klinikum der Universitat, Ludwig Maximilians Universitat, Marchioninistrasse 15, 81377 Munich, Germany
    Nat Rev Immunol 13:34-45. 2013
    b>Thrombosis is the most frequent cause of mortality worldwide and is closely linked to haemostasis, which is the biological mechanism that stops bleeding after the injury of blood vessels...
  5. pmc Microparticles in hemostasis and thrombosis
    A Phillip Owens
    Division of Hematology Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, North Carolina, USA
    Circ Res 108:1284-97. 2011
    ..TF(+) MPs are derived from tumors and may serve as a useful biomarker to identify patients at risk for venous thrombosis. This review will summarize our current knowledge of the role of procoagulant MPs in hemostasis and thrombosis.
  6. pmc Platelets in inflammation and atherogenesis
    Meinrad Gawaz
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Clin Invest 115:3378-84. 2005
    Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs...
  7. ncbi The interactions between inflammation and coagulation
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Br J Haematol 131:417-30. 2005
    ..Hence, downregulation of anticoagulant pathways not only promotes thrombosis but also amplifies the inflammatory process...
  8. doi Cytochrome p-450 polymorphisms and response to clopidogrel
    Jessica L Mega
    Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 360:354-62. 2009
    ..Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles conferring reduced function...
  9. doi A shear gradient-dependent platelet aggregation mechanism drives thrombus formation
    Warwick S Nesbitt
    The Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Educational Precinct, Melbourne, Victoria, Australia
    Nat Med 15:665-73. 2009
    Platelet aggregation at sites of vascular injury is essential for hemostasis and arterial thrombosis. It has long been assumed that platelet aggregation and thrombus growth are initiated by soluble agonists generated at sites of vascular ..
  10. pmc Extracellular DNA traps promote thrombosis
    Tobias A Fuchs
    Immune Disease Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:15880-5. 2010
    ..Markers of extracellular DNA traps were detected in a thrombus and plasma of baboons subjected to deep vein thrombosis, an example of inflammation-enhanced thrombosis...
  11. ncbi Platelet activation and atherothrombosis
    Giovanni Davi
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    N Engl J Med 357:2482-94. 2007
  12. doi Mechanisms of thrombus formation
    Bruce Furie
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, USA
    N Engl J Med 359:938-49. 2008
  13. pmc In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology
    Michelle Tsai
    Department of Bioengineering, University of California, Berkeley, California, USA
    J Clin Invest 122:408-18. 2012
    ..interactions among blood cells, endothelial cells, and soluble factors lead to microvascular occlusion and thrombosis. Here, we report an in vitro "endothelialized" microfluidic microvasculature model that recapitulates and ..
  14. pmc Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Lori Ann Linkins
    Department of Medicine, McMaster University, Juravinski Hospital, Rm M0118, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada
    Chest 141:e495S-530S. 2012
    ....
  15. pmc Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Shannon M Bates
    Department of Medicine, McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
    Chest 141:e351S-418S. 2012
    ..This guideline focuses on the identification of optimal strategies for the diagnosis of DVT in ambulatory adults...
  16. pmc Patient values and preferences in decision making for antithrombotic therapy: a systematic review: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Samantha MacLean
    Department of Biostatistics and Clinical Epidemiology, McMaster University, Hamilton, ON, Canada
    Chest 141:e1S-23S. 2012
    ..We conducted a systematic review relating to values and preferences of patients considering antithrombotic therapy...
  17. doi Bleeding risk assessment and management in atrial fibrillation patients. Executive Summary of a Position Document from the European Heart Rhythm Association [EHRA], endorsed by the European Society of Cardiology [ESC] Working Group on Thrombosis
    Gregory Y H Lip
    Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, City Hospital Birmingham, Birmingham B18 7QH, UK
    Thromb Haemost 106:997-1011. 2011
    ..from the European Heart Rhythm Association, endorsed by the European Society of Cardiology Working Group on Thrombosis, we comprehensively review the published evidence and propose a consensus on bleeding risk assessments in atrial ..
  18. doi Sepsis, thrombosis and organ dysfunction
    Nicola Semeraro
    Department of Biomedical Sciences and Human Oncology, Section of General, Experimental and Clinical Pathology, University of Bari, Bari, Italy
    Thromb Res 129:290-5. 2012
    ..to acute disseminated intravascular coagulation (DIC), characterized by widespread microvascular thrombosis and subsequent consumption of platelets and coagulation proteins, eventually causing bleeding manifestations...
  19. doi New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper
    Raffaele De Caterina
    G D Annunzio University, Chieti, Italy
    J Am Coll Cardiol 59:1413-25. 2012
    ..Although convenient to administer and manage, they present challenges that need to be addressed...
  20. doi Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention: a time-dependent analysis of the Gauging Responsiveness with a VerifyNow P2Y12 assay: Impact on Thrombosis and Safety (GRAVITAS) trial
    Matthew J Price
    Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA, USA
    Circulation 124:1132-7. 2011
    In the Gauging Responsiveness With A VerifyNow P2Y12 Assay: Impact on Thrombosis and Safety (GRAVITAS) trial, 6 months of high-dose clopidogrel did not reduce cardiovascular events compared with standard-dose clopidogrel in patients with ..
  21. pmc An important role for Akt3 in platelet activation and thrombosis
    Kelly A O'Brien
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA
    Blood 118:4215-23. 2011
    ..Importantly, Akt3(-/-) mice showed retardation in FeCl₃-induced carotid artery thrombosis in vivo. Thus, Akt3 plays an important and distinct role in platelet activation and in thrombosis.
  22. pmc Association between changes in air pollution levels during the Beijing Olympics and biomarkers of inflammation and thrombosis in healthy young adults
    David Q Rich
    Department of Community and Preventive Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA
    JAMA 307:2068-78. 2012
    ..Air pollution is a risk factor for cardiovascular diseases (CVD), but the underlying biological mechanisms are not well understood...
  23. pmc Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo
    Nicolas Collin
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA
    Arterioscler Thromb Vasc Biol 32:2185-98. 2012
    ..The aim of the present study was to identify the unique salivary anticoagulant of the sand fly Lutzomyia longipalpis, which remained elusive for decades...
  24. pmc Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 141:e326S-50S. 2012
    ..This guideline addresses the management of patients who are receiving anticoagulant or antiplatelet therapy and require an elective surgery or procedure...
  25. ncbi Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis
    Patrick Andre
    Millennium Pharmaceuticals, Inc, 256 E Grand Ave, South San Francisco, Calif 9408, USA
    Circulation 108:2697-703. 2003
    ..This study was designed to determine whether (1) P2Y12 antagonism synergizes with other antithrombotics and (2) anticoagulants (thrombin inhibitors) affect the antithrombotic activity elicited by P2Y12 antagonism...
  26. ncbi Platelet-collagen interaction: is GPVI the central receptor?
    Bernhard Nieswandt
    Department of Vascular Biology, Rudolf Virchow Center for Experimental Biomedicine Versbacher, Wurzburg, Germany
    Blood 102:449-61. 2003
    ..This review discusses these recent developments and proposes possible mechanisms for how GPVI acts in concert with other receptors and signaling pathways to initiate hemostasis and arterial thrombosis.
  27. ncbi Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke
    Hua Cai
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA
    Circulation 106:2854-8. 2002
    ..We hypothesized that atrial fibrillation (AF) causes a downregulation of atrial endocardial NOS expression and NO* production. Because NO* has antithrombotic properties, this may contribute to thromboembolism in AF...
  28. doi Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am Heart J 162:597-605. 2011
    ..Yet, it remains unknown whether direct inhibition of inflammation will reduce cardiovascular event rates...
  29. ncbi Protease-activated receptors in hemostasis, thrombosis and vascular biology
    S R Coughlin
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 0130, USA
    J Thromb Haemost 3:1800-14. 2005
    ..An important role for PARs in hemostasis and thrombosis is established in animal models, and studies in knockout mice and nonhuman primates raise the question of ..
  30. doi Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis
    Dirk Sibbing
    Deutsches Herzzentrum and Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Am Coll Cardiol 53:849-56. 2009
    The aim of this prospective trial was to assess whether platelet reactivity to clopidogrel assessed with multiple electrode platelet aggregometry (MEA) correlates with the risk of early drug-eluting stent thrombosis (ST).
  31. pmc Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-κB/tissue factor/Factor Xa pathway in melanoma B16F10 cells
    Yang Zhao
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People s Republic of China
    PLoS ONE 8:e56557. 2013
    ..Our previous studies demonstrated that hGAG efficiently inhibited tumor cell metastasis. The interplays between thrombosis and tumor progression may have a major impact on hematogenous metastasis...
  32. ncbi Platelet adhesion signalling and the regulation of thrombus formation
    Jonathan M Gibbins
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, PO Box 228, Reading, Berkshire RG6 6AJ, UK
    J Cell Sci 117:3415-25. 2004
    Platelets perform a central role in haemostasis and thrombosis. They adhere to subendothelial collagens exposed at sites of blood vessel injury via the glycoprotein (GP) Ib-V-IX receptor complex, GPVI and integrin alpha(2)beta(1)...
  33. doi Mechanisms underlying FeCl3-induced arterial thrombosis
    A Eckly
    UMR S949 Inserm Université de Strasbourg, Strasbourg, France
    J Thromb Haemost 9:779-89. 2011
    The FeCl(3)-induced vascular injury model is widely used to study thrombogenesis in vivo, but the processes leading to vascular injury and thrombosis are poorly defined.
  34. doi Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
    Irina Pleines
    Chair of Vascular Medicine, University Hospital Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Josef Schneider Strasse 2, Wurzburg, Germany
    Blood 119:1054-63. 2012
    ..in markedly prolonged tail bleeding times but also significant protection in different models of arterial thrombosis and in a model of ischemic stroke...
  35. doi Platelet-leukocyte interactions in thrombosis
    Chiara Cerletti
    Research Laboratories, Fondazione di Ricerca e Cura Giovanni Paolo II, Universita Cattolica, 86100 Campobasso, Italy
    Thromb Res 129:263-6. 2012
    ..Platelet-leukocyte aggregates provide a novel link between inflammation and thrombosis, two central processes in atherogenesis...
  36. pmc Mononuclear cell therapy reverts cuff-induced thrombosis in apolipoprotein E-deficient mice
    Leandro C F Lima
    Laboratory of Transgenes and Cardiovascular Control, Department Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
    Lipids Health Dis 11:96. 2012
    ..The aim of this study was to investigate the effects of mononuclear cell (MNC) therapy in situ on carotid cuff-induced occlusive thrombus in the apolipoprotein E knockout (apoE-/-) mouse...
  37. pmc Neutrophil granulocyte-dependent proteolysis enhances platelet adhesion to the arterial wall under high-shear flow
    N Wohner
    Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary
    J Thromb Haemost 8:1624-31. 2010
    ..Under high shear stress platelets adhere preferentially to the adventitia layer of the arterial vessel wall in a von Willebrand factor (VWF)-dependent manner...
  38. ncbi Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents
    Ioannis Iakovou
    Centro Cuore Columbus and San Raffaele Hospital, Milan, Italy
    JAMA 293:2126-30. 2005
    Traditionally, stent thrombosis has been regarded as a complication of percutaneous coronary interventions during the first 30 postprocedural days...
  39. doi Impact of the everolimus-eluting stent on stent thrombosis: a meta-analysis of 13 randomized trials
    Usman Baber
    Mount Sinai School of Medicine, Zena and Michael A Weiner Cardiovascular Institute, 1190 Fifth Avenue 1 South, New York, NY 10029, USA
    J Am Coll Cardiol 58:1569-77. 2011
    We evaluated the impact of the everolimus-eluting stent (EES) on the frequency of stent thrombosis (ST), target vessel revascularization (TVR), myocardial infarction (MI), and cardiac death in randomized controlled trials comparing the ..
  40. ncbi Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis
    Abderrahim Nemmar
    Laboratory of Pneumology Lung Toxicology, KULeuven, B 3000 Leuven, Belgium
    Toxicol Appl Pharmacol 186:38-45. 2003
    ..amine-modified (60 or 400 nm) polystyrene particles on bronchoalveolar lavage (BAL) indices and on peripheral thrombosis in hamster...
  41. pmc Pro-coagulant state resulting from high levels of soluble P-selectin in blood
    P Andre
    The Center for Blood Research, and Department of Pathology, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:13835-40. 2000
    ..We propose that sP-sel should no longer be considered only as a marker of inflammation or platelet activation, but also as a direct inducer of pro-coagulant activity associated with vascular and thrombotic diseases...
  42. pmc Serpins in thrombosis, hemostasis and fibrinolysis
    J C Rau
    Department of Pathology and Laboratory Medicine, Carolina Cardiovascular Biology Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7035, USA
    J Thromb Haemost 5:102-15. 2007
    ..coagulation, protein C and fibrinolytic pathways, can be disrupted, resulting in the pathological conditions of thrombosis or abnormal bleeding...
  43. ncbi Signaling events underlying thrombus formation
    S P Jackson
    Australian Center for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill, Victoria, Australia
    J Thromb Haemost 1:1602-12. 2003
    ..The role of soluble agonists in promoting thrombus growth will be highlighted and a model to explain the synergistic requirement for adhesive and soluble stimuli for efficient platelet aggregation will be discussed...
  44. ncbi Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease
    Elizabeth A Varga
    Department of Internal Medicine, of Human Genetics, The Ohio State University, Columbus, Ohio, USA
    Circulation 111:e289-93. 2005
  45. ncbi The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis
    Guy A Zimmerman
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Crit Care Med 30:S294-301. 2002
    To review the platelet-activating factor (PAF) signaling system, its regulation, and its dysregulation in acute inflammation and thrombosis and in syndromes that involve these cascades, including sepsis.
  46. pmc Triggers, targets and treatments for thrombosis
    Nigel Mackman
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nature 451:914-8. 2008
    b>Thrombosis--localized clotting of the blood--can occur in the arterial or the venous circulation and has a major medical impact...
  47. ncbi Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis
    Nigel Mackman
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Code SP30 3040, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 27:1687-93. 2007
    ..TF expression within the vasculature likely contributes to thrombosis in a variety of diseases...
  48. doi Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis
    Tullio Palmerini
    Istituto di Cardiologia, Policlinico S Orsola, Bologna, Italy
    Lancet 379:1393-402. 2012
    The relative safety of drug-eluting stents and bare-metal stents, especially with respect to stent thrombosis, continues to be debated...
  49. doi Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis
    Olivier Morel
    Faculte de Medecine, Institut d Hématologie et d Immunologie, Universite de Strasbourg, Strasbourg, 67085, France
    Semin Immunopathol 33:469-86. 2011
    ..A better understanding of the molecular mechanisms involved in MP shedding would pave the way of a new pharmacological approach aiming at the control of MP-driven cellular responses...
  50. ncbi Mean platelet volume: a link between thrombosis and inflammation?
    Armen Yuri Gasparyan
    Clinical Research Unit, Russell s Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, West Midlands, UK
    Curr Pharm Des 17:47-58. 2011
    Platelet activation is a link in the pathophysiology of diseases prone to thrombosis and inflammation...
  51. pmc Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Anne Holbrook
    Division of Clinical Pharmacology and Therapeutics, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 141:e152S-84S. 2012
    ..This article focuses on the common important management questions for which, at a minimum, low-quality published evidence is available to guide best practices...
  52. pmc Primary and secondary prevention of cardiovascular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Per Olav Vandvik
    Norwegian Knowledge Centre for Health Services and Department of Medicine, Innlandet Hospital Trust Gjøvik, Gjøvik, Norway
    Chest 141:e637S-68S. 2012
    ..This guideline focuses on long-term administration of antithrombotic drugs designed for primary and secondary prevention of cardiovascular disease, including two new antiplatelet therapies...
  53. doi The role of platelets in atherothrombosis
    Zane S Kaplan
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct, Monash University, Melbourne, Australia
    Hematology Am Soc Hematol Educ Program 2011:51-61. 2011
    ..of high shear stress, as occurs in stenotic atherosclerotic arteries, is central to the development of arterial thrombosis; therefore, precise control of platelet adhesion must occur to maintain blood fluidity and to prevent thrombotic ..
  54. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
    ..Our results indicate that platelets are not only involved in haemostasis but that they also directly initiate an inflammatory response of the vessel wall...
  55. ncbi Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes
    Maud B Gorbet
    Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, Room 407D, Toronto, Ont, Canada M5S 3G9
    Biomaterials 25:5681-703. 2004
    ..non-thrombogenic materials may reflect a failure to fully understand the mechanisms of biomaterial-associated thrombosis. The community has focused on minimizing coagulation or minimizing platelet adhesion and activation...
  56. pmc PKCalpha regulates platelet granule secretion and thrombus formation in mice
    Olga Konopatskaya
    Department of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Clin Invest 119:399-407. 2009
    ..In summary, the effects of PKCalpha ablation on thrombus formation and granule secretion may implicate PKCalpha as a drug target for antithrombotic therapy...
  57. pmc Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis
    Mélanie Demers
    Immune Disease Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:13076-81. 2012
    Cancer-associated thrombosis often lacks a clear etiology. However, it is linked to a poor prognosis and represents the second-leading cause of death in cancer patients...
  58. pmc Iron and thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Ann Hematol 87:167-73. 2008
    ..The results of the literature on the effect of iron deficiency and overload on vascular health are critically reviewed in this study from a pathogenic and clinical point of view...
  59. doi Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial
    Shamir R Mehta
    McMaster University and Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    Lancet 376:1233-43. 2010
    ..We assessed the effect of various clopidogrel and aspirin regimens in prevention of major cardiovascular events and stent thrombosis in patients undergoing PCI.
  60. ncbi Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh, Scotland
    Circulation 99:1411-5. 1999
    ..Smoking is a known risk factor for arterial thrombosis and myocardial infarction, and it causes endothelial dysfunction...
  61. doi P2 receptors, platelet function and pharmacological implications
    Christian Gachet
    Institut National de la Sante et de la Recherche Medicale, U311, Strasbourg, France
    Thromb Haemost 99:466-72. 2008
    ..Finally, the regulation by the P2 receptors of the platelet involvement in inflammatory processes is also briefly discussed...
  62. doi Platelet receptor signaling in thrombus formation
    David Stegner
    Chair of Vascular Medicine, University Hospital and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    J Mol Med (Berl) 89:109-21. 2011
    ..This review summarizes the most important receptor systems and signaling mechanisms involved in platelet activation and thrombus formation with special focus on recent discoveries...
  63. pmc Risk factors for catheter-related thrombosis (CRT) in cancer patients: a patient-level data (IPD) meta-analysis of clinical trials and prospective studies
    W Saber
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Thromb Haemost 9:312-9. 2011
    Knowledge of independent, baseline risk factors for catheter-related thrombosis (CRT) may help select adult cancer patients who are at high risk to receive thromboprophylaxis.
  64. pmc Human umbilical cord blood-derived endothelial cells reendothelialize vein grafts and prevent thrombosis
    Melissa A Brown
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Arterioscler Thromb Vasc Biol 30:2150-5. 2010
    To accelerate vein graft reendothelialization and reduce vein graft thrombosis by infusing human umbilical cord blood-derived endothelial cells (hCB-ECs) because loss of endothelium contributes to vein graft thrombosis and neointimal ..
  65. ncbi Adaptation of a photochemical method to initiate recurrent platelet-mediated thrombosis in small animals
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Lasers Med Sci 22:42-5. 2007
    Platelet-mediated thrombosis represents the initial precipitating event in the genesis of unstable angina, acute myocardial infarction, and stroke...
  66. ncbi Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF
    Markus Guba
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Blood 105:4463-9. 2005
    ..The circumstance that VEGF is up-regulated in most tumors may explain the remarkable selectivity of tumor vessel thrombosis under rapamycin therapy...
  67. pmc The role of von Willebrand factor in thrombus formation
    Zaverio M Ruggeri
    The Scripps Research Institute, La Jolla, California, USA
    Thromb Res 120:S5-9. 2007
    ..and aggregation of platelets at sites of vascular injury, processes that are critical for both haemostasis and thrombosis. Thrombus formation involves complex events that are influenced by different environmental conditions...
  68. doi Dynamics of platelet thrombus formation
    S P Jackson
    The Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    J Thromb Haemost 7:17-20. 2009
    ..Unraveling the dynamics of platelet aggregation and thrombus formation in vivo requires consideration of the cooperative interplay between rheological- and soluble agonist-dependent platelet aggregation mechanisms...
  69. ncbi Prasugrel versus clopidogrel in patients with acute coronary syndromes
    Stephen D Wiviott
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 357:2001-15. 2007
    ..Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention...
  70. doi Everolimus-eluting versus paclitaxel-eluting stents in coronary artery disease
    Gregg W Stone
    Columbia University Medical Center New York Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY 10022, USA
    N Engl J Med 362:1663-74. 2010
    ..Previous studies have established the superiority of coronary everolimus-eluting stents over paclitaxel-eluting stents with respect to angiographic findings. However, these trials were not powered for superiority in clinical end points...
  71. pmc The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation
    Brian G Petrich
    Department of Medicine, UCSD School of Medicine, La Jolla, California 92093 0726, USA
    J Clin Invest 117:2250-9. 2007
    ..beta(3)(L746A) mice were resistant to both pulmonary thromboembolism and to ferric chloride-induced thrombosis of the carotid artery...
  72. ncbi Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice
    Haim D Danenberg
    Harvard MIT Division of Health Sciences and Technology, Cambridge, Mass 02139, USA
    Circulation 108:512-5. 2003
    ..To determine whether CRP directly modulates vascular cell function in vivo, we subjected wild-type mice, which do not express CRP, and human CRP-transgenic (CRPtg) mice to 2 models of arterial injury...
  73. pmc Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals
    Koji Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    Proc Natl Acad Sci U S A 99:890-5. 2002
    ..induction of PAI-1 mRNA by stress increased markedly with age, and this increase in PAI-1 correlated with tissue thrombosis in the older stressed mice...
  74. doi Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity
    Silvia Deaglio
    Department of Genetics, Biology, and Biochemistry, University of Turin and Human Genetics Foundation, Italy
    Adv Pharmacol 61:301-32. 2011
    ..Ongoing development of therapeutic strategies targeting these and other ectonucleotidases offers promise for the management of vascular thrombosis, disordered inflammation, and aberrant immune reactivity.
  75. pmc P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice
    Christian Furlan-Freguia
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 121:2932-44. 2011
    b>Thrombosis is initiated by tissue factor (TF), a coagulation cofactor/receptor expressed in the vessel wall, on myeloid cells, and on microparticles (MPs) with variable procoagulant activity...
  76. pmc Development of a novel echocardiography ramp test for speed optimization and diagnosis of device thrombosis in continuous-flow left ventricular assist devices: the Columbia ramp study
    Nir Uriel
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Am Coll Cardiol 60:1764-75. 2012
    ..This study sought to develop a novel approach to optimizing continuous-flow left ventricular assist device (CF-LVAD) function and diagnosing device malfunctions...
  77. doi Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis
    Erica Villa
    Department of Gastroenterology, Azienda Ospedaliero Universitaria and University of Modena and Reggio Emilia, Modena, Italy
    Gastroenterology 143:1253-60.e1-4. 2012
    We performed a randomized controlled trial to evaluate the safety and efficacy of enoxaparin, a low-molecular-weight heparin, in preventing portal vein thrombosis (PVT) in patients with advanced cirrhosis.
  78. doi Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin
    E O Kozlowski
    Institute of Physiology, University of Zürich and Zürich Center for Integrative Human Physiology, Zurich, Switzerland
    J Thromb Haemost 9:1807-15. 2011
    Cancer-associated thrombosis and enduring inflammation are strongly associated with cancer progression and metastasis...
  79. pmc In vitro microvessels for the study of angiogenesis and thrombosis
    Ying Zheng
    Department of Bioengineering, Center for Cardiovascular Biology, Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 109:9342-7. 2012
    ..in vitro could provide a platform for the study of complex vascular phenomena, including angiogenesis and thrombosis. We have engineered living microvascular networks in three-dimensional tissue scaffolds and demonstrated their ..
  80. pmc Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University Faculty of Health Sciences, Hamilton, ON, Canada
    Chest 141:53S-70S. 2012
    To develop the Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: ACCP Evidence-Based Clinical Practice Guidelines (AT9), the American College of Chest Physicians (ACCP) assembled a panel of clinical experts, information ..
  81. doi Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke
    B Nieswandt
    Vascular Medicine, University Hospital Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    J Thromb Haemost 9:92-104. 2011
    ..This review summarises recent developments in understanding the principal platelet adhesion receptor systems with a focus on their involvement in arterial thrombosis and ischaemic stroke models.
  82. doi Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease
    Sergey Zharikov
    Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Biochem Soc Trans 41:118-23. 2013
    ..In the present article, we provide a brief overview of what is currently known about the function of mitochondria in platelets and review how platelet mitochondria have been used to study mitochondrial function in human disease...
  83. doi Unexpected abrupt increase in left ventricular assist device thrombosis
    Randall C Starling
    From the Departments of Cardiovascular Medicine R C S, M M M, Thoracic and Cardiovascular Surgery N M, E H B, E G S, B W L, N G S, and Quantitative Health Sciences E H B, J E, L T and Kaufman Center for Heart Failure R C S, N M, E H B, M M M, E G S, N G S, Cleveland Clinic, Cleveland the Division of Cardiovascular Surgery S C S and the Cardiovascular Division G E, Barnes Jewish Hospital, Washington University School of Medicine, St Louis the Cardiology Division J G R and the Cardiovascular Surgery Division C A M, Duke University School of Medicine, Durham, NC and the Divisions of Cardiology J E R and Cardiovascular Surgery M A A, University of Pennsylvania, Philadelphia
    N Engl J Med 370:33-40. 2014
    We observed an apparent increase in the rate of device thrombosis among patients who received the HeartMate II left ventricular assist device, as compared with preapproval clinical-trial results and initial experience...
  84. pmc Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Dr, 3160 ML, Iowa City, IA 52242, USA
    Circulation 127:1308-16. 2013
    ..To investigate the prothrombotic role of oxidative stress during aging, we tested the hypothesis that aged mice overexpressing the antioxidant enzyme glutathione peroxidase-1 (Gpx1) are protected from experimental thrombosis.
  85. ncbi Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo
    Steffen Massberg
    Klinikum rechts der Isar, 1 Medizinische Klinik, Technische Universitat Munchen, D 81675 Munchen, Germany
    FASEB J 18:397-9. 2004
    Platelet-collagen interactions play a fundamental role in the process of arterial thrombosis. The major platelet collagen receptor is the glycoprotein VI (GPVI)...
  86. ncbi The role of microparticles in inflammation and thrombosis
    S P Ardoin
    Division of Rheumatology and Immunology, Duke University Medical Center, Medical Research Service, Durham VA Hospital, Durham, NC, USA
    Scand J Immunol 66:159-65. 2007
    ..MP) are small membrane-bound vesicles that circulate in the peripheral blood and play active roles in thrombosis, inflammation and vascular reactivity...
  87. pmc Differential contributions of monocyte- and platelet-derived microparticles towards thrombin generation and fibrin formation and stability
    M M Aleman
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    J Thromb Haemost 9:2251-61. 2011
    Microparticles (MPs) are sub-micron vesicles shed by activated or apoptotic cells, including platelets and monocytes. Increased circulating MPs are associated with thrombosis; however, their role in thrombogenesis is poorly understood.
  88. pmc Regulating thrombus growth and stability to achieve an optimal response to injury
    L F Brass
    Department of Medicine and Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thromb Haemost 9:66-75. 2011
    ....
  89. ncbi Wingspan in-stent restenosis and thrombosis: incidence, clinical presentation, and management
    Elad I Levy
    Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Millard Fillmore Gates Hospital, Kaleida Health, Buffalo, New York, USA
    Neurosurgery 61:644-50; discussion 650-1. 2007
    ..The current series reports the observed incidence of in-stent restenosis (ISR) and thrombosis on angiographic follow-up.
  90. doi Thrombosis in cancer: an update on prevention, treatment, and survival benefits of anticoagulants
    Agnes Y Y Lee
    Thrombosis Program, Vancouver Coastal Health Vancouver General Hospital, and Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Hematology Am Soc Hematol Educ Program 2010:144-9. 2010
    ..who might benefit from primary thromboprophylaxis, treatment options for those with established or recurrent thrombosis, and the potential antineoplastic effects of anticoagulants...
  91. doi Arterial thrombosis--insidious, unpredictable and deadly
    Shaun P Jackson
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct, Monash University, Melbourne, Australia
    Nat Med 17:1423-36. 2011
    The formation of blood clots--thrombosis--at sites of atherosclerotic plaque rupture is a major clinical problem despite ongoing improvements in antithrombotic therapy...
  92. ncbi Platelet physiology and thrombosis
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    Thromb Res 114:447-53. 2004
    ..This review will focus on the structure-function of primary platelet adhesion receptors, GPIb-IX-V and GPVI, and how they act together to regulate platelet thrombus formation in pathophysiology...
  93. doi Laser-induced thrombosis in zebrafish
    Pudur Jagadeeswaran
    Department of Biological Sciences, University of North Texas, Denton, Texas, USA
    Methods Cell Biol 101:197-203. 2011
    ..Therefore, we developed a global laser induced thrombosis method which can assay all these components...
  94. doi The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation
    Sonia Philipose
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, A 8010 Graz, Austria
    Arterioscler Thromb Vasc Biol 30:2416-23. 2010
    ..The platelet-stimulating effect of PGE(2) has been suggested to involve EP3 receptors. Here we analyzed the receptor usage relating to the inhibitory effect of PGE(2)...
  95. ncbi Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysis
    Carl van Walraven
    Clinical Epidemiology Unit, Ottawa Health Research Institute, F 6, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
    JAMA 288:2441-8. 2002
    ..Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and other vascular events...
  96. ncbi Clinical, imaging, and pathological characteristics of left ventricular thrombus: a comparison of contrast-enhanced magnetic resonance imaging, transthoracic echocardiography, and transesophageal echocardiography with surgical or pathological validation
    Monvadi B Srichai
    Center for Integrated Non Invasive Cardiovascular Imaging of Department of Radiology Section of Cardiovascular Imaging, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 152:75-84. 2006
    ....
  97. pmc Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice
    Giuseppina Caligiuri
    INSERM U460, Paris, France
    Mol Med 9:10-7. 2003
    ..Furthermore, markers of systemic coagulation were increased, and vascular thrombosis in response to i.v. thrombin occurred more frequently in E-/- x IL-10-/- than in E-/- mice...
  98. doi Thrombosis in multiple myeloma
    Sigurdur Yngvi Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden
    Hematology Am Soc Hematol Educ Program 2010:437-44. 2010
    Patients with multiple myeloma (MM) are at an increased risk of venous and arterial thrombosis. The pathogenesis remains unclear, but probably involves several factors such as activation of procoagulant factors, acquired activated protein ..
  99. ncbi Predictors of survival after deep vein thrombosis and pulmonary embolism: a population-based, cohort study
    J A Heit
    Department of Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    Arch Intern Med 159:445-53. 1999
    ....
  100. doi Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working
    Wiktor Kuliczkowski
    3rd Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland
    Eur Heart J 30:426-35. 2009
    ..The present position paper, conveyed within a group of clinical cardiologists with expertise in thrombosis appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, has been further ..
  101. doi Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus
    Xavier Houard
    INSERM U698, Paris 7 Denis Diderot University, Cardiovascular Hematology, Bio Engineering and Remodeling, Bichat Claude Bernard Hospital, 75877 Paris Cedex 18, France
    FASEB J 23:1376-83. 2009
    ....

Research Grants78

  1. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  2. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..and CPB, thus establishing a new substrate for CPB and providing a novel molecular link between hemostasis/thrombosis and tissue inflammation and immunity. Aim 1...
  3. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..dimension to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis. To facilitate comparisons with our South Asian sample, we will assay analytes previously studied in GWAS of ..
  4. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Antiphospholipid (aPL) antibodies (Abs) are associated with thrombosis and pregnancy loss in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS)...
  5. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..has been implicated in the pathogenesis of many cardiovascular and neurovascular diseases such atherosclerosis, thrombosis, stroke and many more...
  6. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..including atherosclerosis, autoimmunity, allograft rejection, the diabetes-metabolic syndrome, hemostasis and thrombosis, and wound healing...
  7. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
    ..significantly to the pathogenesis of common clinical disorders such as myocardial infarction, deep vein thrombosis, pulmonary embolism, and stroke...
  8. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2012
    ..Nearly 576,000 new cases of deep vein thrombosis and pulmonary embolism, two of the most common thrombotic conditions, are diagnosed every year in the US alone...
  9. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..Almost all MIs are caused by rupture of coronary atherosclerotic plaques with superimposed coronary thrombosis resulting in ischemia...
  10. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    Endothelial dysfunction and platelet aggregation cause pulmonary artery vasoconstriction, mitogenesis, thrombosis, and vascular obliteration in pulmonary arterial hypertension (PAH) The recognition of abnormal eicosanoid metabolism and ..
  11. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
    ..provided by applicant): Blood platelets are required for hemostasis and abnormal platelet activation leads to thrombosis. Cellular and molecular mechanisms of platelet assembly within, and their release from, megakaryocytes (MKs) ..
  12. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
    ..important for health, whereas low B6 status is associated with increased risk of cardiovascular disease, venous thrombosis and stroke...
  13. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    Dudley K Strickland; Fiscal Year: 2013
    ..e. LRP, LDLR and VLDLR) modulate localized thrombosis by promoting the rapid cellular internalization of the macromolecular Xase complex...
  14. Surgical Revascularization's Impact on Mitochondria in Hibernating Myocardium
    ROSEMARY FRANCES KELLY; Fiscal Year: 2013
    ..angina, indicate that the heart is transiently stressed by increased work load demands, by spasm or fluctuating thrombosis in one of the arteries prior to its complete closure...
  15. Examination of the Final Stages of Platelet Production
    JONATHAN NOAH THON; Fiscal Year: 2013
    ..Research. Blood PLTs play an essential role in hemostasis and the pathophysiology of thrombosis. My interests lay in investigating the mechanisms of PLT formation for the purpose of developing targeted ..
  16. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2013
    ..to further our understanding of diverse forms of pathophysiology in which inflammation plays a role, including thrombosis and atherogenesis...
  17. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
    ..e., anti-platelet agents) for both thrombosis and inflammation", as stipulated in 04-HL-103...
  18. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
    ..growth restriction, racial disparities, maternal immunization, and maternal medical conditions - particularly thrombosis and hemostasis...
  19. STRUCTURE AND FUNCTION OF HEPARIN COFACTOR II
    Douglas M Tollefsen; Fiscal Year: 2010
    ..in combination with factor V Leiden or protein Z deficiency will be observed for evidence of spontaneous thrombosis or other abnormalities...
  20. Treatment of stroke with a clinically approved proteasome inhibitor
    Li Zhang; Fiscal Year: 2012
    ..use for the treatment of cancer, effectively reduces cerebral infarction, and concomitantly reduces secondary thrombosis and microvascular permeability in young rats...
  21. Thiol Isomerases During Thrombus Formation
    Barbara C Furie; Fiscal Year: 2013
    ..released from platelets and endothelial cells, and their contribution to the modulation of function of proteins involved in thrombosis and hemostasis, including but not limited to GPIb, GPIIbIIIa and tissue factor.
  22. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    JAMES ANTHONY SHEERIN MULDOWNEY; Fiscal Year: 2013
    The fibrinolytic system is the physiologic counterbalance to the thrombosis cascade. The generation, extent, and location of the fibrin clot are critical when hemostasis is compromised...
  23. Gene expression responses to air pollution and modification by genetic variation
    Sharine Wittkopp; Fiscal Year: 2013
    ..elevated PM levels have been associated with increased levels of circulating biomarkers of inflammation and thrombosis. There is little data regarding gene expression in relevant biological pathways in relation to PM exposure in ..
  24. Novel Antithrombotic Diadenosine Tetraphosphate Analogs
    IVAN B YANACHKOV; Fiscal Year: 2013
    DESCRIPTION: Undesired platelet activation can be result of many common pathologies or interventions. Arterial thrombosis and the acute ischemic events that follow, such as myocardial infarction and stroke, are among the leading causes ..
  25. Tissue Factor &Clot Formation In Abdominal Aortic Aneurysm
    ALBERT PHILLIP OWENS; Fiscal Year: 2013
    ..Nigel Mackman, an expert in the field of coagulation and thrombosis. I still have much to learn from Dr. Mackman regarding the function of tissue factor in vascular disease...
  26. Prolylcarboxypeptidase is a Risk Factor for Cardiovascular Disease
    Alvin H Schmaier; Fiscal Year: 2013
    ..Moreover, they are prothrombotic with shorter arterial thrombosis occlusion times after carotid artery photochemical- or ferric chloride-induced injury...
  27. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2012
    How platelets support homeostasis in the vascular system is a paradigm-central question in hemostasis and thrombosis. The importance of the platelet glycoprotein (GP) Ib-IX/von Willebrand factor axis in this process is well-established ..
  28. Identification of novel target genes for polycythemia vera (PV)
    Shaoguang Li; Fiscal Year: 2013
    ..Ph-) MPNs are also derived from hematopoietic stem cells (HSCs) and have a risk of developing thrombosis and acute leukemia. There are still no curative therapies for these Ph- MPNs...
  29. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    ..g. ischemic stroke, myocardial infarction, pulmonary embolism, and deep vein thrombosis. The presence of thrombus changes treatment decisions and imaging is widely used rule in, or out, the presence ..
  30. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
    ..S. patients each year. Primary APS in some severe cases leads to death via emergency venous thrombosis/embolism;and secondary APS compounds other autoimmune diseases such as lupus and venous thromboembolism...
  31. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ..1) neutrophilia promotes platelet activation and vascular occlusion in mouse models of bleeding time, arteriolar thrombosis, and stroke;2) neutrophil cathepsin G is a critical molecular mediator of platelet accumulation and luminal ..
  32. Identification of small molecule inhibitors of protein disulfide isomerase
    ROBERT C FLAUMENHAFT; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Arterial thrombosis mediates tissue infarction in coronary artery disease, cerebrovascular disease, and peripheral vascular disease, and thus is the single most common cause of morbidity and mortality ..
  33. Autologous EPC lining to improve biocompatibility of circulatory assist devices
    Jeffrey H Lawson; Fiscal Year: 2010
    ..of blood with their inner surface (usually titanium) often causes a coagulopathy resulting in bleeding and thrombosis. Local areas of low flow and blood stasis in most MCADs also contribute to the risk for thrombosis, especially ..
  34. Regulation of Leukocyte Migration by Plasminogen
    JANE LEE HOOVER-PLOW; Fiscal Year: 2013
    ..role of the Plg system in recruitment of inflammatory cells, thereby providing a clear and direct link between thrombosis and inflammation...
  35. Mechanisms of vascular-specific gene regulation by estrogen
    Gavin R Schnitzler; Fiscal Year: 2013
    ..cancer, and in a combination of beneficial and harmful gene expression changes related to lipid metabolism and thrombosis. Bioinformatic analysis of these data will identify transcription factors in each tissue that are likely to ..
  36. Mechanisms of airborne particulate matter induced thrombosis
    Gokhan M Mutlu; Fiscal Year: 2013
    ..that acute exposure to PM causes lung macrophages to release interleukin-6 (IL-6), which accelerates arterial thrombosis in mice, a finding supported by human studies...
  37. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Background / Rationale: Deep vein thrombosis (DVT) and its complications are a significant source of morbidity and mortality among Americans, and have increased in the Veteran population over the last ..
  38. Manipulation of Host Angiogenesis as a Therapeutic Strategy against Invasive Pulm
    Dimitrios P Kontoyiannis; Fiscal Year: 2010
    ..may be linked to the propensity of Aspergillus species to invade pulmonary blood vessels, causing intravascular thrombosis, tissue ischemia and infarction...
  39. Vascular Structure and Function in Arteriovenous Fistula Maturation
    Jonathan Himmelfarb; Fiscal Year: 2012
    ..The arteriovenous fistula (AVF) is the preferred type of vascular access due to substantially lower thrombosis rates, infection rates, and total health care expenditures...
  40. Translational studies of the Platelet Specific Receptor Trem Like Transcript (TLT
    A Valance Washington; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Thrombosis remains one of largest causes of mortality and morbidity in the western world...
  41. The Role of Complement in the Pathogenesis of Preeclampsia
    MICHAEL PAUL TRIEBWASSER; Fiscal Year: 2013
    ..studies of families with preeclampsia and in the following pathways implicated by the literature: complement, thrombosis, cell cycle, apoptosis, angiogenesis, and endothelial cell activation...
  42. New Pathways in Thrombosis and Inflammation Mediated by Semaphorin-Plexin Signali
    Guy A Zimmerman; Fiscal Year: 2010
    ..These features make it ideal for the Challenge Grant initiative. Thrombosis and inflammation are intricately linked in the pathogenesis of acute coronary syndromes, stroke, sepsis, acute ..
  43. Screening for allosteric modulators of the protease activated receptor 4
    Heidi E Hamm; Fiscal Year: 2013
    ..Platelets play a critical role in thrombosis, the major cause of mortality and morbidity...
  44. MECHANISMS OF ARTERIAL GRAFT HEALING
    Alexander W Clowes; Fiscal Year: 2013
    ..25-30% of all grafts because of pathological remodeling and intimal hyperplasia, is a primary cause of graft thrombosis. Despite decades of research, almost nothing is known about the factors that account for the variability in ..
  45. CVD protection mechanisms involving ACE2/Ang-(1-7) axis
    Mohan K Raizada; Fiscal Year: 2013
    ..and establishment of cardiovascular diseases leading to devastating outcomes such as coronary artery disease, thrombosis, myocardial infarction, hypertrophy, and heart failure...
  46. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..According to the Surgeon General's 2008 Call to Action to Prevent Deep Venous Thrombosis and Pulmonary Embolism, over 300,000 Americans each year suffer from venous thromboembolism (VTE), with ..
  47. Role of Maternal Platelets in the Placenta and Pregnancy Complications
    Rashmi Sood; Fiscal Year: 2013
    ..It is unclear how blood flow is maintained in these vascular spaces and what leads to pathological thrombosis. The dynamics of interplay between coagulation and inflammation remain undefined;these are likely to of ..
  48. Vascular Mechanisms in Homocysteinemia and Atherosclerosis
    Steven R Lentz; Fiscal Year: 2012
    ..hyperhomocysteinemia and hypercholesterolemia that lead to vascular dysfunction, neointima formation, and thrombosis. Our preliminary data suggest that hyperhomocysteinemia and hypercholesterolemia induce cellular stress ..
  49. Novel Biomarkers Predictive of Heparin-Induced Thrombocytopenia
    Barbara A Konkle; Fiscal Year: 2010
    ..b>Thrombosis is the major cause of death in the United States and heparin, in unfractionated (UFH) or low molecular weight ..
  50. The Regulation of Inflammatory Responses by CD73
    Linda F Thompson; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The overall goal of this proposal is to better understand how inflammation and thrombosis are regulated by adenosine...
  51. MiR-181b, endothelial cells, and vascular inflammation
    Mark W Feinberg; Fiscal Year: 2013
    ..g. COX-2, PAI-1) that are critical to lesion formation, composition, or pre-disposition to thrombosis. Gain and loss-of function studies reveal that miR-181b potently inhibited leukocyte adhesion to endothelial ..
  52. Smooth Muscle Cell Tissue Factor and Cardiovascular Disease
    Mark B Taubman; Fiscal Year: 2013
    ..Tissue Factor (TF), the initiator of the coagulation cascade, plays a critical role in hemostasis and thrombosis. There are numerous sources of TF in the vasculature, including macrophages, endothelial cells, and smooth ..
  53. Role of influenza-induced prothrombosis in Streptococcus pyogenes superinfections
    Michael S Chaussee; Fiscal Year: 2012
    ..pyogenes superinfections. Influenza infection induces thrombosis, which results in fibrinogen/fibrin (Fb) and fibronectin (Fn) deposition in the respiratory tract...
  54. Chemopreventative properties of Medicinal and Food plants of the Lumbee Tribe
    TRACIE LOCKLEAR; Fiscal Year: 2010
    ..as the association of tamoxifen with increased risk of cervical and endometrial cancers, deep vein thrombosis and pulmonary emboli has been well established (Fisher B. et al., 1998;Rovere et al., 2006)...
  55. Structural and Biochemical Basis of the Vitamin K cycle
    Weikai Li; Fiscal Year: 2013
    ..VKOR is the target of warfarin, the most commonly used oral anticoagulant for treating and preventing thrombosis diseases including deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction...
  56. 12-HETrE regulation of platelets
    MICHAEL ALLAN HOLINSTAT; Fiscal Year: 2013
    ..how 12-LOX oxidation of DGLA can potentially lead to regulation of a number of physiological processes including thrombosis, inflammation, immunity and regulation of tumor growth...
  57. Tobacco Products and Atherosclerotic Disease
    Sanjay Srivastava; Fiscal Year: 2013
    ..In these experiments, we will identify specific indices of atherosclerosis and thrombosis and how these biomarkers of injury are related to the biomarkers of exposure...
  58. Novel Molecules in Calcium Signaling in Platelets
    Wolfgang Bergmeier; Fiscal Year: 2013
    ..provided by applicant): Platelets are of great importance for many pathophysiological processes, including thrombosis, hemorrhage, inflammation, and cancer...
  59. Physiology and Molecular Biology of Factor XI
    David Gailani; Fiscal Year: 2013
    ..role in hemostasis, a variety of data now make a compelling case that fXI contributes to arterial and venous thrombosis and is, therefore, an attractive candidate for targeted therapy to treat or prevent thromboembolic disease...
  60. Recombinant and Chemo-/Bio-Orthogonal Synthesis of Liposomal Thrombomodulin
    Xue Long Sun; Fiscal Year: 2013
    ..Antithrombotic agents can be used for both prevention and treatment of active vascular thrombosis. However, current antithrombotic therapy is limited by the risk of bleeding, hemorrhagic complication...
  61. Thromboresistant Polymers via Catalytic Generation of NO
    Mark E Meyerhoff; Fiscal Year: 2012
    ..will have immediate applications for preparing/coating a host of medical implants to reduce the risk of in vivo thrombosis. PUBLIC HEALTH RELEVANCE: There is a great need in the biomedical community for novel polymeric coatings that ..
  62. Transcriptomic, Oxidative Stress, and Inflammatory Responses to Air Pollutants
    Ralph J Delfino; Fiscal Year: 2013
    ..PM chemical species from fossil fuel combustion are causative factors in oxidative stress, inflammation, thrombosis, and vascular dysfunction, which have the potential to precipitate adverse events such as myocardial infarction...
  63. Factor XI in Thrombosis
    David Gailani; Fiscal Year: 2013
    ..However, mice lacking fXII, similar to those lacking fXI, are resistant to thrombosis, suggesting contact activation (or a process similar to it) contributes to pathologic coagulation...
  64. Vascular Function, Cognition, and Brain MRI in Atherosclerotic Vascular Disease
    David J Moser; Fiscal Year: 2012
    ..We have published cross-sectional findings in Stroke and in Arteriosclerosis, Thrombosis, and Vascular Biology showing that this measure of vascular function is significantly related to cognition in ..
  65. 3D Structure and Function of CRAC Channels
    STEPHEN BARSTOW LONG; Fiscal Year: 2013
    ..is also required for platelet activation and breast tumor cell migration, suggesting that channel inhibitors may have therapeutic applications for preventing arterial thrombosis, ischemic brain infarction, and breast cancer metastasis.
  66. ENDOTHELIAL INJURY AND CYTOPROTECTION
    JACK HAWIGER; Fiscal Year: 1993
    ..seeding of fibrin thrombi on the vessel wall a process contributing to an estimated 5 million episodes of venous thrombosis and 1.5 million cases of acute coronary thrombosis per year in the United States...
  67. ANTIBODIES WITH PROTHROMBINASE ACTIVITY IN LUPUS
    Perumal Thiagarajan; Fiscal Year: 2003
    ..Prothrombin binding autoantibodies from lupus patients are clinically associated with thrombosis, but the association is paradoxical, because conventional mechanisms of antibody action predict decreased ..
  68. Antithrombotic Therapy and Prevention of Thrombosis: ACCP Evidence-Based Clinical
    Sandra Zelman Lewis; Fiscal Year: 2010
    ..IL on February 9-10, 2011 as part of the process of developing the Antithrombotic Therapy and Prevention of Thrombosis: ACCP Evidence-based Clinical Practice Guidelines, 9th Edition (AT9) that will be published as a CHEST ..
  69. Integrated Multifunctional Imaging of Deep Vein Thrombosis
    Walter Scott; Fiscal Year: 2009
    Deep venous thrombosis (DVT), and its sequelae, pulmonary embolism (PE), is a significant clinical problem, representing the leading cause of preventable in-hospital mortality in the USA and other developed countries...
  70. HEPARIN INDUCED THROMBOCYTOPENIA/THROMBOSIS
    GIAN VISENTIN; Fiscal Year: 2000
    Heparin-induced thrombocytopenia/thrombosis (HITP) is an important cause of morbidity and mortality in patients receiving heparin therapy...
  71. A Novel Thin Film Nitinol Covered Stent to Treat Peripheral Arterial Disease
    David A Rigberg; Fiscal Year: 2010
    ..by the lack of a suitable, biocompatible surface for the covering of these blood-contacting devices that lead to thrombosis. The availability of an appropriate, thrombus resistant material for endovascular devices could lead to ..
  72. N3 FATTY ACIDS EFFECT ON SICKLE CELL PAIN EPISODES
    James Eckman; Fiscal Year: 2001
    ..have platelet activation, increased thrombin formation and fibrinolysis, in vivo, and that activation of thrombosis increases significantly during pain episodes...
  73. Antithrombotic Gene Therapy
    Pierre Zoldhelyi; Fiscal Year: 2006
    b>Thrombosis, complicating a ruptured plaque, is ultimately responsible for the majority of cardiac mortality and morbidity in the Western World, including most instances of heart failure...
  74. Controlled Release Vascular Grafts
    ANTONIO WEBB; Fiscal Year: 2009
    ..ePTFE) grafts are the most commonly used alternative despite dismal patency rates due to the formation of thrombosis and neointimal hyperplasia...
  75. INTEGRATIVE APPROACH TO CORONARY THROMBOSIS
    Robert Montgomery; Fiscal Year: 2001
    ..The current understanding of thrombosis occurring in the coronary circulation is that: following a plaque rupture or damage to the endothelium, the ..
  76. Role of Vascular Heterogeneity in Thrombosis
    Barbara Furie; Fiscal Year: 2006
    ..In vivo studies in mouse models of thrombosis are beginning to challenge paradigms of initiation and extension of thrombi largely based on in vitro and ex ..
  77. THROMBIN AND VWF IN SHIGA-TOXIN-ASSOCIATED HUS
    Thomas Raife; Fiscal Year: 2001
    ..hemolytic uremic syndrome (HUS) is a thrombotic microangiopathic disorder in which microvascular thrombosis is a leading cause of acute and chronic organ injury...
  78. THERAPY WITH ANNEXINS FOR ANTIPHOSPHOLIPID SYNDROME
    MARIA BEGONA CAMPOS NACIFF; Fiscal Year: 2004
    DESCRIPTION: (Scanned from the applicant's description): APS is a disorder characterized by venous and arterial thrombosis, recurrent fetal loss, thrombocytopenia and by the presence of antiphospholipid antibodies...