embolism

Summary

Summary: Blocking of a blood vessel by a blood clot or foreign matter that has been transported from a distant site by the blood stream.

Top Publications

  1. pmc Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation
    Anuraag R Kansal
    United BioSource Corporation, Bethesda, Maryland, USA
    Heart 98:573-8. 2012
  2. ncbi Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Eur Heart J 32:2387-94. 2011
  3. pmc Embolic protection device use in renal artery stent placement
    Mallik R Thatipelli
    St Elizabeth s Medical Center, Boston, Massachusetts, USA
    J Vasc Interv Radiol 20:580-6. 2009
  4. ncbi Dabigatran versus rivaroxaban for the prevention of stroke and systemic embolism in atrial fibrillation in Canada. Comparative efficacy and cost-effectiveness
    Anuraag R Kansal
    United BioSource Corporation, Bethesda, MD 20814, USA
    Thromb Haemost 108:672-82. 2012
  5. ncbi Emboli capture using the Embol-X intraaortic filter in cardiac surgery: a multicentered randomized trial of 1,289 patients
    Michael K Banbury
    The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 76:508-15; discussion 515. 2003
  6. ncbi Risk of embolism and death in infective endocarditis: prognostic value of echocardiography: a prospective multicenter study
    Franck Thuny
    Department of Cardiology, La Timone Hospital, Marseille, France
    Circulation 112:69-75. 2005
  7. ncbi Randomized trial of a distal embolic protection device during percutaneous intervention of saphenous vein aorto-coronary bypass grafts
    Donald S Baim
    Division of Cardiovascular Diseases, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 105:1285-90. 2002
  8. ncbi Recommendations for echocardiography use in the diagnosis and management of cardiac sources of embolism: European Association of Echocardiography (EAE) (a registered branch of the ESC)
    Mauro Pepi
    Centro Cardiologico Monzino, IRCCS, Department Cardiovascular Sciences, University of Milan, Via Parea 4, 20138 Milan, Italy
    Eur J Echocardiogr 11:461-76. 2010
  9. ncbi Fibrocartilaginous embolism of the spinal cord diagnosed by characteristic clinical findings and magnetic resonance imaging in 26 dogs
    Yuya Nakamoto
    Kyoto Animal Medical Center, Kuzegun, Kyoto, Japan
    J Vet Med Sci 71:171-6. 2009
  10. ncbi Percutaneous closure of patent foramen ovale in cryptogenic embolism
    Bernhard Meier
    Department of Cardiology, Bern University Hospital, Bern, Switzerland
    N Engl J Med 368:1083-91. 2013

Detail Information

Publications303 found, 100 shown here

  1. pmc Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation
    Anuraag R Kansal
    United BioSource Corporation, Bethesda, Maryland, USA
    Heart 98:573-8. 2012
    To assess the cost-effectiveness of dabigatran etexilate, a new oral anticoagulant, versus warfarin and other alternatives for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation (AF).
  2. ncbi Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment
    Keith A A Fox
    Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Eur Heart J 32:2387-94. 2011
    ..Rivaroxaban, an oral, direct factor Xa inhibitor metabolized predominantly by the liver, preserves the benefit of warfarin for stroke prevention while causing fewer intracranial and fatal haemorrhages...
  3. pmc Embolic protection device use in renal artery stent placement
    Mallik R Thatipelli
    St Elizabeth s Medical Center, Boston, Massachusetts, USA
    J Vasc Interv Radiol 20:580-6. 2009
    ....
  4. ncbi Dabigatran versus rivaroxaban for the prevention of stroke and systemic embolism in atrial fibrillation in Canada. Comparative efficacy and cost-effectiveness
    Anuraag R Kansal
    United BioSource Corporation, Bethesda, MD 20814, USA
    Thromb Haemost 108:672-82. 2012
    ..anticoagulation is appropriate have two new choices for anticoagulation for prevention of stroke and systemic embolism--dabigatran etexilate (dabigatran) and rivaroxaban...
  5. ncbi Emboli capture using the Embol-X intraaortic filter in cardiac surgery: a multicentered randomized trial of 1,289 patients
    Michael K Banbury
    The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 76:508-15; discussion 515. 2003
    ..Particulate emboli are thought to play a significant role in the development of cardiac surgical complications. Intraaortic filtration of particulate emboli may reduce the burden of this morbidity in cardiac patients...
  6. ncbi Risk of embolism and death in infective endocarditis: prognostic value of echocardiography: a prospective multicenter study
    Franck Thuny
    Department of Cardiology, La Timone Hospital, Marseille, France
    Circulation 112:69-75. 2005
    ..Moreover, the exact role of echocardiography in risk stratification is not well defined...
  7. ncbi Randomized trial of a distal embolic protection device during percutaneous intervention of saphenous vein aorto-coronary bypass grafts
    Donald S Baim
    Division of Cardiovascular Diseases, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 105:1285-90. 2002
    ..We report the first multicenter randomized trial to evaluate use of a distal embolic protection device during stenting of such lesions...
  8. ncbi Recommendations for echocardiography use in the diagnosis and management of cardiac sources of embolism: European Association of Echocardiography (EAE) (a registered branch of the ESC)
    Mauro Pepi
    Centro Cardiologico Monzino, IRCCS, Department Cardiovascular Sciences, University of Milan, Via Parea 4, 20138 Milan, Italy
    Eur J Echocardiogr 11:461-76. 2010
    b>Embolism of cardiac origin accounts for around 15-30% of ischaemic strokes. Strokes due to cardioembolism are generally severe and early and long-term recurrence and mortality are high...
  9. ncbi Fibrocartilaginous embolism of the spinal cord diagnosed by characteristic clinical findings and magnetic resonance imaging in 26 dogs
    Yuya Nakamoto
    Kyoto Animal Medical Center, Kuzegun, Kyoto, Japan
    J Vet Med Sci 71:171-6. 2009
    Fibrocartilaginous embolism (FCE) is a disorder of acute onset that presents with nonprogressive ataxia...
  10. ncbi Percutaneous closure of patent foramen ovale in cryptogenic embolism
    Bernhard Meier
    Department of Cardiology, Bern University Hospital, Bern, Switzerland
    N Engl J Med 368:1083-91. 2013
    The options for secondary prevention of cryptogenic embolism in patients with patent foramen ovale are administration of antithrombotic medications or percutaneous closure of the patent foramen ovale...
  11. ncbi Early predictors of in-hospital death in infective endocarditis
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 109:1745-9. 2004
    ..Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE...
  12. ncbi Dabigatran for the prevention of stroke and systemic embolism in atrial fibrillation: A NICE single technology appraisal
    Rita Faria
    Centre for Health Economics, Alcuin A Block, University of York, Heslington, York, YO10 5DD, UK
    Pharmacoeconomics 31:551-62. 2013
    ..to submit evidence for the clinical and cost-effectiveness of this drug for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (AF) as part of the NICE single technology appraisal process...
  13. pmc Renal cement embolism during percutaneous vertebroplasty
    Seung Eun Chung
    Department of Diagnostic Radiology, Wooridul Spine Hospital, Seoul, Republic of Korea
    Eur Spine J 15:590-4. 2006
    ..We encountered a renal embolism of PMMA in a 57-year-old man that occurred during PVP...
  14. ncbi Renal artery stent revascularization with embolic protection in patients with ischemic nephropathy
    A Holden
    Department of Radiology, Auckland City Hospital, Park Road, Grafton, Auckland, New Zealand
    Kidney Int 70:948-55. 2006
    ..Patients most likely to receive the greatest benefit are those with mild baseline chronic renal insufficiency and a recent decline in renal function...
  15. ncbi Rare forms of peripheral arterial embolism: review of 11 cases
    Marković Miroslav
    Institute for Cardiovascular Diseases, Clinical Center of Serbia, Belgrade, Serbia and Montenegro
    Vascular 13:222-9. 2005
    The purpose of this study was to present 11 patients operated on owing to rare forms of peripheral arterial embolism at the Institute for Cardiovascular Diseases of the Serbian Clinical Center over a period of 20 years...
  16. ncbi Risk of embolization after institution of antibiotic therapy for infective endocarditis
    Isidre Vilacosta
    Instituto de Cardiologia, Hospital Universitario San Carlos, Madrid, Spain
    J Am Coll Cardiol 39:1489-95. 2002
    ..This study was designed to assess the risk of systemic embolization in patients with left-sided infective endocarditis, once adequate antibiotic treatment had been initiated, on the basis of prospective clinical follow-up...
  17. pmc Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Eur Heart J 30:2897-907. 2009
    ..We report from a Phase II randomized, dose-guiding study (NCT00684307) to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of extended-release AZD0837 in patients with AF...
  18. ncbi (18)F-FDG PET/CT for early detection of embolism and metastatic infection in patients with infective endocarditis
    Jelle Van Riet
    Department of Nuclear Medicine, University Hospital KU Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 37:1189-97. 2010
    ..A single whole-body scan investigating inflammatory changes could be very helpful to achieve a swift and efficient assessment...
  19. ncbi Randomized comparison of distal protection with a filter-based catheter and a balloon occlusion and aspiration system during percutaneous intervention of diseased saphenous vein aorto-coronary bypass grafts
    Gregg W Stone
    Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, 55 E 59th St, 6th Floor, New York, NY 10022, USA
    Circulation 108:548-53. 2003
    ..Whether filter-based catheters, which offer the inherent advantages of maintained perfusion and ease of use, are as effective for this purpose has not been established...
  20. ncbi Microsphere embolism-induced endothelial nitric oxide synthase expression mediates disruption of the blood-brain barrier in rat brain
    Feng Han
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Neurochem 99:97-106. 2006
    Microsphere embolism (ME)-induced up-regulation of endothelial nitric oxide synthase (eNOS) in endothelial cells of brain microvessels was observed 2-48 h after ischemia...
  21. ncbi Distal embolism during percutaneous revascularization of infra-aortic arterial occlusive disease: an underestimated phenomenon
    Dimitris Karnabatidis
    Department of Radiology, Angiography Suite, University Hospital of Patras, Rion, Greece
    J Endovasc Ther 13:269-80. 2006
    To investigate distal embolism during endovascular procedures of the infra-aortic arteries by utilizing a commercial filter basket and unveil any correlation between the baseline clinical and procedural variables and the histopathological ..
  22. ncbi Structural remodeling of the left atrial appendage in patients with chronic non-valvular atrial fibrillation: Implications for thrombus formation, systemic embolism, and assessment by transesophageal echocardiography
    J Shirani
    Departments of Medicine Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cardiovasc Pathol 9:95-101. 2000
    ..occurs frequently in chronic AF and may contribute to the increased risk of thrombus formation and systemic embolism. Additionally, the information may have relevance in interpreting transesophageal echocardiographic images of the ..
  23. ncbi Floating intra-aortic thrombus presenting as distal arterial embolism
    Dimitrios Pousios
    Department of Cardiothoracic Surgery, Wessex Cardiac Unit, Southampton General Hospital, Southampton, UK
    Interact Cardiovasc Thorac Surg 9:532-4. 2009
    ..This was a result of peripheral embolism originating in a floating thrombus in the ascending aorta...
  24. pmc Calcific retinal embolism as an indicator of severe unrecognised cardiovascular disease
    G Ramakrishna
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Heart 91:1154-7. 2005
    To describe the association between calcific retinal embolism (CRE) and cardiac valve stenosis.
  25. ncbi Usefulness of an early diagnosis for the favorable prognosis of fibrocartilaginous embolism diagnosed by magnetic resonance imaging in 10 small- to middle-sized dogs
    Yuya Nakamoto
    Ozawa Animal Hospital, 4, Niban Uji, Uji, Kyoto, 611 0021, Japan
    Vet Res Commun 32:609-17. 2008
    Fibrocartilaginous embolism (FCE), a disorder of rapid onset featured by nonprogressive paralysis and paresis of four legs, shows clinical symptoms very similar to those of other disorders, e.g., disk herniation...
  26. pmc Thrombus growth and embolism on tissue factor-bearing collagen surfaces under flow: role of thrombin with and without fibrin
    Thomas V Colace
    Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, 1024 Vagelos Research Laboratories, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 32:1466-76. 2012
    ..Using microfluidic flow devices as well as patterned surfaces of collagen and tissue factor (TF), we sought to determine the role that fibrin plays in clot stability without interfering with the production of thrombin...
  27. ncbi Prevention of cardiopulmonary embolization of polymethylmethacrylate cement fragment after kyphoplasty with insertion of inferior vena cava filter
    Mouchammed Agko
    Department of Surgery, The University of Toledo Medical Center, Toledo, Ohio 43614, USA
    J Vasc Surg 51:210-3. 2010
    ..Endovascular technique was used to retrieve it to the common femoral vein with subsequent successful removal of the crescent-like fragment with operative exploration. Patient was asymptomatic at four-week follow-up visit...
  28. pmc Mortality from infective endocarditis: clinical predictors of outcome
    S M Wallace
    Department of Cardiology, The Middlesex Hospital, University College London Hospitals NHS Trust, London, UK
    Heart 88:53-60. 2002
    ..To identify clinical markers available within the first 48 hours of admission that are associated with poor outcome in infective endocarditis...
  29. ncbi Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation
    Karsten M H Bruins Slot
    Department of Internal Medicine, Oslo University Hospital, Oslo, Norway, NO 0407
    Cochrane Database Syst Rev 8:CD008980. 2013
    ..A new class of anticoagulants, the factor Xa inhibitors, appear to have several pharmacological and practical advantages over VKAs...
  30. ncbi Prediction of symptomatic embolism in infective endocarditis: construction and validation of a risk calculator in a multicenter cohort
    Sandrine Hubert
    Département de Cardiologie Hôpital Universitaire de la Timone, Assistance Publique Hopitaux de Marseille, Aix Marseille Universite, Marseille, France Service de Chirurgie Cardiaque, Hôpital Universitaire de La Timone, Assistance Publique Hopitaux de Marseille, Aix Marseille Universite, Marseille, France
    J Am Coll Cardiol 62:1384-92. 2013
    ..The aim of this study was to develop and validate a simple calculator to quantify the embolic risk (ER) at admission of patients with infective endocarditis...
  31. ncbi Fibrocartilaginous embolism in 75 dogs: clinical findings and factors influencing the recovery rate
    G Gandini
    Department of Veterinary Clinical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Bologna, Italy
    J Small Anim Pract 44:76-80. 2003
    The records of 75 dogs with fibrocartilaginous embolism of the spinal cord were evaluated retrospectively. The diagnosis was confirmed histopathologically in 21 dogs (group A) and remained suspected in 54 patients (group B)...
  32. ncbi Apixaban: a review of its use for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
    Gillian M Keating
    Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore 0754, Auckland, New Zealand
    Drugs 73:825-43. 2013
    ..This article reviews the efficacy and tolerability of oral apixaban to reduce the risk of stroke or systemic embolism in patients with nonvalvular atrial fibrillation (AF)...
  33. ncbi Microvascular tumor embolism: independent prognostic factor after liver transplantation in hepatocellular carcinoma
    H H Lee
    Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Transplant Proc 37:1251-3. 2005
    ..The presence of microvascular tumor embolism was undetermined as a factor for HCC recurrence after orthotopic liver transplantation (OLT)...
  34. ncbi Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K ant
    Jonathan P Piccini
    Division of Cardiology, Duke University Medical Center, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27710, USA
    Circulation 127:224-32. 2013
    We sought to define the factors associated with the occurrence of stroke and systemic embolism in a large, international atrial fibrillation (AF) trial.
  35. ncbi Peripheral arterial embolism: prevalence, outcome, and the role of echocardiography in management
    J A Gossage
    St Thomas Hospital, London, UK
    Vasc Endovascular Surg 40:280-6. 2006
    ..Transthoracic echocardiography is a good screening tool for detecting a potential cardiac source for peripheral embolism, with transesophageal echocardiography being reserved for specific indications.
  36. ncbi Popliteal artery bullet embolism in a case of homicide: a case report and review of the tangible literature
    Savic Slobodan
    Institute of Forensic Medicine, School of Medicine, University of Belgrade, Deligradska 31a, 11000, Belgrade, Serbia and Montenegro
    Forensic Sci Int 139:27-33. 2004
    Bullet embolism is a well known but a relatively rare phenomenon in common medicolegal autopsy practice...
  37. ncbi Current incidence of peripheral arterial embolism and role of echocardiography
    Arash Mohammadi Tofigh
    Imam Hussein Hospital, Shahid Beheshti University MC, Tehran, Iran
    Asian Cardiovasc Thorac Ann 16:439-43. 2008
    We reviewed the incidence and outcome of all cases of upper and lower limb embolism surgically treated in our vascular unit, from January 2001 to June 2006, to assess the role of transthoracic and transesophageal echocardiography in ..
  38. ncbi Left ventricular hypertrabeculation/noncompaction and stroke or embolism
    Claudia Stollberger
    Medizinische Abteilung, Krankenanstalt Rudolfstiftung, Wien, Osterreich
    Cardiology 103:68-72. 2005
    Left ventricular hypertrabeculation/noncompaction (LVHT) is reported to be associated with embolism. This retrospective study assessed the number of strokes/embolisms in 62 patients with LVHT and in 62 control patients matched with regard ..
  39. ncbi Clinical differentiation between acute arterial embolism and acute arterial thrombosis of the lower extremities
    Pramook Mutirangura
    Vascular Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 92:891-7. 2009
    The primary treatments of acute arterial embolism and acute arterial thrombosis are different. The clinical differentiation of the two diseases at initial stage can provide the efficient treatment of acute limb ischemia.
  40. ncbi Peripheral arterial embolism arising from pulmonary adenocarcinoma
    Jesus Loscertales
    Department of General and Thoracic Surgery, Virgen Macarena University Hospital, Seville, Spain
    Ann Thorac Surg 77:1426-8. 2004
    Bronchogenic carcinoma is a rare source of peripheral arterial embolism. We present the case of a 28-year-old female nonsmoker with an adenocarcinoma of the left main bronchus involving the pulmonary veins...
  41. ncbi Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation
    S Bertil Olsson
    Department of Cardiology, Lund University Hospital, Lund, Sweden
    Thromb Haemost 103:604-12. 2010
    ..In conclusion, the safety and tolerability of 150mg bid immediate-release AZD0837 appeared to be as good as that of dose-adjusted warfarin. However, larger studies will be needed to define the safety profile of AZD0837...
  42. ncbi Extracorporeal membrane oxygenation for diffuse alveolar hemorrhage and severe hypoxemic respiratory failure from silicone embolism
    L B Mongero
    Department of Clinical Perfusion, Columbia University Medical Center, New York, NY, USA
    Perfusion 25:249-52; discussion 253-4. 2010
    ..respiratory failure has been widely reported, to our knowledge, this is the first reported successful use of ECMO for silicone embolism syndrome associated with diffuse alveolar hemorrhage and severe hypoxemic respiratory failure.
  43. ncbi Images in cardiovascular medicine. Right ventricular acupuncture needle embolism detected on coronary computed tomography angiography
    Young Jin Kim
    Department of Radiology, Yonsei University College of Medicine, Severance Hospital, 134 Sinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Circulation 114:e623-6. 2006
  44. ncbi Late embolization of Amplatzer patent ductus arteriosus occlusion device with thoracic aorta embedment
    David Michael McMullan
    Cardiovascular Surgery, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Ann Thorac Surg 83:1177-9. 2007
    ..Angiography confirmed that the occlusion device had migrated to the descending thoracic aorta. The child underwent surgical removal of the device, which was firmly embedded in the aorta and could not be removed percutaneously...
  45. ncbi Aortic embolism of cement: a rare complication of lumbar percutaneous vertebroplasty
    Nicolas Amoretti
    Department of Radiology, Hopital L Archet, 06200 Nice Cedex 1, France
    Skeletal Radiol 36:685-7. 2007
    ..Proper techniques can minimize the risk of arterial embolism caused by cement during the procedure.
  46. ncbi Transesophageal echocardiography and cardiovascular sources of embolism: implications for perioperative management
    Christine Ngukhoon Tan
    Department of Anaesthesia and Intensive Care Medicine, University Hospital of Wales, Cardiff, United Kingdom
    Anesthesiology 107:333-46. 2007
    ..Patients who receive anesthesia and critical care may be at risk of systemic embolism from various cardiovascular sources...
  47. ncbi Hyperbaric treatment of arterial CO2 embolism occuring after laparoscopic surgery: a case report
    R S Reust
    Oklahoma State University Center for Health Sciences, Tulsa, OK, USA
    Undersea Hyperb Med 33:317-20. 2006
    Arterial carbon dioxide (CO2) embolism is a serious and sometimes fatal iatrogenic medical condition encountered in surgery. A thirty-five year old Caucasian female developed a CO2 embolism during a laparoscopic appendectomy...
  48. ncbi [A case of advanced gastric cancer with tumor embolus in the portal vein successfully treated with S-1 and CDDP therapy]
    Yoshihide Asaumi
    Dept of Surgery, Fukui Prefectural Hospital, Japan
    Gan To Kagaku Ryoho 38:1175-8. 2011
    ....
  49. ncbi [Mesenteric ischemia caused by embolism in atrial fibrillation]
    Camila Paiva de Vasconcelos
    Hospital Israelita Albert Einstein, Sao Paulo, SP
    Rev Assoc Med Bras 51:309. 2005
  50. ncbi Frequency of stroke and embolism in left ventricular hypertrabeculation/noncompaction
    Claudia Stollberger
    Krankenanstalt Rudolfstiftung, Vienna, Austria
    Am J Cardiol 108:1021-3. 2011
    Left ventricular hypertrabeculation/noncompaction (LVHT/NC) is associated with stroke or embolism (S/E). The aim of this retrospective study was to assess the rate, risk factors, and cause of S/E in patients with LVHT/NC...
  51. ncbi [Basilar artery occlusion due to embolism from the vertebral artery: three case reports]
    Osamu Kikuchi
    Department of Neurosurgery, Teine Keijinkai Medical Center, Japan
    No Shinkei Geka 38:669-73. 2010
    ..We report three cases of basilar artery occlusion due to vertebral artery thrombo-embolism. In all cases, the cause of the strokes was artery to artery embolism from the vertebral artery origin...
  52. ncbi Pitfalls of embolic protection
    Mark C Bates
    Department of Surgery, West Virginia University School of Medicine, Charleston, WV 25304, USA
    Tech Vasc Interv Radiol 14:101-7. 2011
    ....
  53. ncbi Warfarin for the prevention of systemic embolism in patients with non-valvular atrial fibrillation: a meta-analysis
    L V Andersen
    Department of Pharmacology, Wilhelm Meyers Alle 240, Aarhus University, Aarhus University Hospital, Aarhus C, Denmark
    Heart 94:1607-13. 2008
    Warfarin for stroke prevention in patients with atrial fibrillation (AF) is well documented. However, it has not been examined in the prevention of systemic embolism.
  54. ncbi Positional compression of the axillary artery causing upper extremity thrombosis and embolism in the elite overhead throwing athlete
    Yazan M Duwayri
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Vasc Surg 53:1329-40. 2011
    ..To describe the spectrum of axillary artery pathology seen in high-performance overhead athletes and the outcomes of current treatment...
  55. ncbi Long-term propensity score-matched comparison of percutaneous closure of patent foramen ovale with medical treatment after paradoxical embolism
    Andreas Wahl
    Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland
    Circulation 125:803-12. 2012
    ..Differences in long-term clinical outcome were investigated among patients with percutaneous PFO closure and those who received medical treatment...
  56. ncbi Dabigatran etexilate: a pharmacoeconomic review of its use in the prevention of stroke and systemic embolism in patients with atrial fibrillation
    Kate McKeage
    Pharmacoeconomics 30:841-55. 2012
    ..Pradaxa®, Pradax™) [hereafter referred to as dabigatran] when used for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF), followed by a review of cost-utility analyses of ..
  57. pmc Renal artery embolism: a case report and review
    Sheru Kansal
    Department of Medicine, The Western Pennsylvania Hospital, Pittsburgh, PA, USA
    J Gen Intern Med 23:644-7. 2008
    Renal artery embolism was first described in 1940, but it is only recently becoming recognized as a clinically significant entity...
  58. ncbi [Risk of embolism in diagnostic and therapeutic intravascular procedures--in vitro model]
    K Zana
    , , Semmelweis Egyetem, Budapest
    Orv Hetil 142:1837-41. 2001
    ..Use of thrombectomy device resulted in significant particle migration (ranging from 400 microns to 1500 microns in length)...
  59. ncbi Acute myocardial infarction caused by coronary embolism from infective endocarditis
    Czarina J Roxas
    University of Massachusetts Memorial Medical Center, Department of Emergency Medicine, Worcester, Massachusetts 01605, USA
    J Emerg Med 40:509-14. 2011
    ..Identifying an acute myocardial infarction caused by a non-atherosclerotic process can have consequences on the short- and long-term management of the disease...
  60. ncbi [Diagnosis and management of acute mesenteric ischemia]
    A Dewitte
    Service d anesthésie réanimation II, CHU de Bordeaux, Maison du Haut Lêveque, Groupe Hospitalier Sud, Université Bordeaux Segalen, Avenue de Magellan, Pessac Cedex, France
    Ann Fr Anesth Reanim 30:410-20. 2011
    ..Surgery should not be delayed in patients suspected of having intestinal necrosis...
  61. ncbi Embolization and transcatheter retrieval of coils and devices
    C A Tan
    Division of Pediatric Cardiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Pediatr Cardiol 26:267-74. 2005
    ..To minimize potential morbidities associated with these retrievals and to maximize efficacy of retrieval, operators performing transcatheter coil or device occlusions must be familiar with retrieval techniques...
  62. pmc "My heart is popping out of my chest": left ventricular pseudoaneurysm with systemic arterial embolism
    H Dokainish
    Heart 93:1169. 2007
  63. ncbi Lacunar infarction: embolism is the key
    Nancy Futrell
    Intermountain Stroke Center, 5292 College Drive, Suite 204, Salt Lake City, UT 84123, USA
    Stroke 35:1778-9. 2004
  64. ncbi A rare cause of peripheral arterial embolism: ruptured cardiac hydatid cyst
    H Ceyran
    Department of Thoracic and Cardiovascular Surgery, Erciyes University, Kayseri, Turkey
    Vasa 31:129-31. 2002
    ..important unfavorable events that occur during the course of the cardiac hydatid cyst is rupture of the cyst and embolism of the germinative membrane...
  65. ncbi Effect of infective endocarditis on blood coagulation and platelet activation and comparison of patients with to those without embolic events
    Mehmet Ileri
    Department of Cardiology, Turkiye Yuksek Ihtisas Hastanesi, Ankara, Turkey
    Am J Cardiol 91:689-92. 2003
    ..The resulting imbalance produces a sustained hypercoagulable state that may contribute to the increased risk of thromboembolic events in this particular group...
  66. ncbi Acute retinal arteriolar emboli after cardiac catheterization
    Andreas J Kreis
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Stroke 39:3086-7. 2008
    There are concerns that cardiac catheterization may cause retinal embolization, a risk marker for cerebrovascular emboli and stroke. We describe the incidence of acute retinal embolism after cardiac catheterization.
  67. ncbi Interventional treatment of septic coronary embolism: sailing into uncharted and dangerous waters
    James J Glazier
    Cardiac Catheterization Laboratory, Harper University Hospital, 3990 John R, Detroit, MI 48201, USA
    J Interv Cardiol 15:305-7. 2002
  68. ncbi Guidelines for percutaneous coronary interventions. The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology
    Sigmund Silber
    Kardiologische Praxis und Praxisklinik, Munchen, Germany
    Eur Heart J 26:804-47. 2005
    ....
  69. ncbi Systematic primary aspiration in acute myocardial percutaneous intervention: a multicentre randomised controlled trial of the export aspiration catheter
    Bernard Chevalier
    Department of Cardiology, Centre Cardiologique du Nord, Saint Denis, France
    EuroIntervention 4:222-8. 2008
    ..It is unclear whether primary aspiration can prevent distal embolisation and thereby improve myocardial perfusion in patients presenting with acute myocardial infarction (AMI) within 12 hours after onset...
  70. ncbi Bullet embolism after gunshot injury: a case report
    Adlan Olsun
    Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey
    Heart Surg Forum 11:E193-4. 2008
    ..injuries, if all entrance points are not paired with exit points, the possibility of an organ or extremity embolism caused by the presence of a bullet or shrapnel fragments in circulation should be borne in mind, although such ..
  71. ncbi Prophylaxis against fat and bone-marrow embolism during total hip arthroplasty reduces the incidence of postoperative deep-vein thrombosis: a controlled, randomized clinical trial
    Rocco Paolo Pitto
    Department of Orthopaedic Surgery, University of Auckland, Middlemore Hospital, Otahuhu, Auckland, New Zealand
    J Bone Joint Surg Am 84:39-48. 2002
    ..We hypothesized that an operative technique designed for the prevention of fat and bone-marrow embolism can also reduce the incidence of postoperative deep-vein thrombosis and pulmonary embolism.
  72. ncbi Impact of single or multicentre study design on the results of trials examining the efficacy of adjunctive devices to prevent distal embolisation during acute myocardial infarction
    Yoichi Inaba
    Division of Cardiovascular Medicine, Oregon Health and Science University, Portland, OR, USA
    EuroIntervention 5:375-83. 2009
    ....
  73. ncbi Randomized comparison of primary percutaneous coronary intervention with combined proximal embolic protection and thrombus aspiration versus primary percutaneous coronary intervention alone in ST-segment elevation myocardial infarction: the PREPARE (PRoxi
    Joost D E Haeck
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    JACC Cardiovasc Interv 2:934-43. 2009
    ..Jude Medical, St. Paul, Minnesota]) in ST-segment elevation myocardial infarction patients...
  74. ncbi Detection of embolic particles with the Doppler guide wire during coronary intervention in patients with acute myocardial infarction: efficacy of distal protection device
    Atsunori Okamura
    Division of Cardiology, Sakurabashi Watanabe Hospital, 2 4 32 Umeda, Kita ku, Osaka 530 0001, Japan
    J Am Coll Cardiol 45:212-5. 2005
    ....
  75. ncbi Limitations of using a GuardWire temporary occlusion and aspiration system in patients with acute myocardial infarction: multicenter investigation of coronary artery protection with a distal occlusion device in acute myocardial infarction (MICADO)
    Akiko Matsuo
    Department of Cardiology, Sendai Kousei Hospital, Japan
    J Invasive Cardiol 19:132-8. 2007
    ..The prevention of no-reflow in PCI is considered a challenge and could be a contributing factor for long-term prognosis...
  76. ncbi Distal protection device protects microvascular integrity during primary percutaneous intervention in acute myocardial infarction: a prospective, randomized, multicenter trial
    Seung Jea Tahk
    Department of Cardiology, Ajou University School of Medicine, San 5 Wonchun Dong, Yeongtong Gu, Suwon, 443 721, Republic of Korea
    Int J Cardiol 123:162-8. 2008
    ..The present study was designed to determine whether the distal embolic protection preserves myocardial microvascular integrity and improves clinical outcomes in patients with AMI...
  77. ncbi Arterial embolism caused by a ruptured hydatid cyst in the heart: report of a case
    Yahya Unlu
    Department of Cardiovascular Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    Surg Today 32:989-91. 2002
    ..We report the case of a 32-year-old woman with an acute arterial embolism caused by a ruptured hydatid cyst in the heart...
  78. ncbi Comparison of myocardial perfusion by distal protection before and after primary stenting for acute myocardial infarction: angiographic and clinical results of a randomized controlled trial
    Toshiya Muramatsu
    Saiseikai Yokohama City Eastern Hospital, Kanagawa, Japan
    Catheter Cardiovasc Interv 70:677-82. 2007
    ..To assess the myocardium-reperfusing effect of a distal protection device, GuardWire Plus (GuardWire Plus), in patients with acute myocardial infarction (AMI)...
  79. ncbi Dabigatran etexilate: a review of its use in the prevention of stroke and systemic embolism in patients with atrial fibrillation
    Karly P Garnock-Jones
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Am J Cardiovasc Drugs 11:57-72. 2011
    ..150 mg twice daily, was shown to be noninferior to warfarin with regard to the incidence of stroke or systemic embolism in a large, randomized, partially blinded, multicenter study in a wide spectrum of patients with atrial ..
  80. ncbi Retinal and cerebral microembolization during coronary artery bypass surgery: a randomized, controlled trial
    Raimondo Ascione
    Bristol Heart Institute, University of Bristol, Bristol, England
    Circulation 112:3833-8. 2005
    ....
  81. ncbi Transoesophageal echocardiography in patients without arterial and major cardiac sources of embolism: difference between stroke subtypes
    P Cerrato
    First Division of Neurology, Istituto Auxologico Italiano, Piancavallo VB, University of Turin, Italy
    Cerebrovasc Dis 13:174-83. 2002
    ..evidence that TEE is a helpful diagnostic tool in stroke patients without arterial and major cardiac sources of embolism. However, its utility differs according to type and localization of the ischaemic lesion being more relevant in ..
  82. ncbi Cerebral embolism from atrial myxoma in pediatric patients
    Majeed Al-Mateen
    Pediatric Neurology Clinic, Mary Bridge Children s Hospital and Health Center, Tacoma, Washington 98415, USA
    Pediatrics 112:e162-7. 2003
    ..Atrial myxoma should be considered in the differential diagnosis when children present with neurologic symptoms or with signs of embolization, because surgical removal of the tumor is critical and may be curative...
  83. ncbi Mitral valve surgery with surgical embolectomy for mitral valve endocarditis complicated by septic coronary embolism
    Man Jong Baek
    Department of Thoracic and Cardiovascular Surgery, Guro Hospital, College of Medicine, Korea University, 80 Guro dong, Guro Ku, Seoul 152 703, Republic of Korea
    Eur J Cardiothorac Surg 33:116-8. 2008
    Acute myocardial infarction (AMI) complicated by septic coronary embolism due to active infective endocarditis is rare but usually fatal...
  84. ncbi Coronary embolism complicating aortic valve endocarditis: treatment with successful coronary angioplasty
    Ertan Ural
    Int J Cardiol 119:377-9. 2007
    ..TIMI-3 flow was obtained after intervention. Antibiotic treatment was continued for 6 weeks. She was uneventful at the end of the 3-month follow-up...
  85. ncbi Clinical and echocardiographic risk factors for embolism and mortality in infective endocarditis
    Evelyn E Hill
    Department of Internal Medicine Infectious Diseases, University Hospital Gasthuisberg K U Leuven, 3000, Leuven, Belgium
    Eur J Clin Microbiol Infect Dis 27:1159-64. 2008
    Data about predictors of embolism in patients with infective endocarditis (IE) are conflicting...
  86. ncbi Time-related distribution, risk factors and prognostic influence of embolism in patients with left-sided infective endocarditis
    José Fabri
    Heart Institute InCor, University of Sao Paulo Medical School, and General Outpatient Clinics Unit, Avenida Dr Enéas de Carvalho Aguiar 44, 05403 000 Sao Paulo, Brazil
    Int J Cardiol 110:334-9. 2006
    Few studies evaluated systemic arterial embolism after beginning of symptoms of infective endocarditis in a large series of patients.
  87. ncbi Lacunar infarction: embolism is the key: against
    Bo Norrving
    Department of Neurology, Lund University Hospital, S 221 85 Lund, Sweden
    Stroke 35:1779-80. 2004
  88. ncbi Anatomical and pathological considerations in percutaneous vertebroplasty and kyphoplasty: a reappraisal of the vertebral venous system
    Rob J M Groen
    Department of Neurosurgery, University Hospital Groningen, Grongingen, The Netherlands
    Spine (Phila Pa 1976) 29:1465-71. 2004
    ....
  89. ncbi Retinal embolization during carotid angioplasty and stenting: mechanisms and role of cerebral protection systems
    James R Wilentz
    Cardiac Catheterization Laboratories and Interventional Cardiology, St Luke s Roosevelt Medical Center, New York, New York 10025, USA
    Catheter Cardiovasc Interv 56:320-7. 2002
    ..Cerebral protection system designs should take into consideration the existence of collaterals and the need to protect against smaller sized emboli, which may cause blindness in the retinal circulation...
  90. ncbi Retinal ischemia and embolism. Etiologies and outcomes based on a prospective study
    V Babikian
    Department of Neurology, Boston University School of Medicine, Boston, Mass, 02130, USA
    Cerebrovasc Dis 12:108-13. 2001
    To identify the most likely mechanisms of retinal ischemia and embolism in a hospital-referred population, and to determine the frequency of recurrent vascular events during the 3-month period following initial presentation.
  91. ncbi Retrograde venous bullet embolism: a rare occurrence-case report and literature review
    Ugo Bertoldo
    Department of Surgery, U O A General and Emergency Surgery, Centro Traumatologico Ortopedico Hospital F E, Turin, Italy
    J Trauma 57:187-92. 2004
  92. ncbi Intraoperative transesophageal echocardiography to assess septic coronary embolism
    Holger K Eltzschig
    Department of Anesthesiology, Perioperative and Pain Medicine, Division of Cardiac Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Anesthesiology 97:1627-9. 2002
  93. ncbi Thrombus-in-transit causing paradoxical embolism in cerebral and coronary arterial circulation
    Muriel Delvigne
    Department of Cardiology, General Hospital AZ Middelheim, Antwerp, Belgium
    Acta Cardiol 59:669-72. 2004
    ..The definite diagnosis of paradoxical embolism was made by means of a transoesophageal echocardiography which demonstrated a large snake-like floating thrombus ..
  94. ncbi Echocardiography predicts embolic events in infective endocarditis
    G Di Salvo
    Department of Cardiology, La Timone Hospital, Marseille, France
    J Am Coll Cardiol 37:1069-76. 2001
    ..EEs) in a large group of patients with definite endocarditis according to the Duke criteria, including silent embolism. BACKGROUND: The value of echocardiography in predicting embolism in patients with endocarditis remains ..
  95. ncbi Randomized trial of low molecular weight heparin (dalteparin) in prevention of left ventricular thrombus formation and arterial embolism after acute anterior myocardial infarction: the Fragmin in Acute Myocardial Infarction (FRAMI) Study
    F Kontny
    Department of Cardiology, Aker University Hospital, Oslo, Norway
    J Am Coll Cardiol 30:962-9. 1997
    ..The present trial investigated the efficacy and safety of dalteparin in the prevention of arterial thromboembolism after an acute anterior myocardial infarction (MI)...
  96. ncbi Echocardiographic and morphologic characteristics of left atrial myxoma and their relation to systemic embolism
    J W Ha
    Yonsei Cardiovascular Center, and Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    Am J Cardiol 83:1579-82, A8. 1999
    We examined the relation between the echocardiographic morphology of cardiac myxoma and systemic embolism in 25 patients...
  97. ncbi Prothrombotic activity is increased in patients with nonvalvular atrial fibrillation and risk factors for embolism
    Hiroshi Inoue
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Chest 126:687-92. 2004
    The aim of this study was to investigate whether risk factors for embolism would promote thrombus formation in patients with nonvalvular atrial fibrillation (NVAF).
  98. ncbi Paradoxical bullet embolism: case report and literature review
    M Schurr
    Department of Surgery, Presley Regional Trauma Center, University of Tennessee Health Science Center, Memphis, USA
    J Trauma 40:1034-6. 1996
    ..Paradoxical emboli are even more unusual. We present a case of a paradoxical bullet embolism from the left external iliac vein to the left common iliac artery via a patent foramen ovale.
  99. pmc Transradial intracoronary catheter-aspiration embolectomy for acute coronary embolism after mitral valve replacement
    Wei Chin Hung
    Section of Cardiology, Division of Internal Medicine, Chang Gung Memorial Hospital at Kaohsiung, Taiwan, Republic of China
    Tex Heart Inst J 30:316-8. 2003
    ..After treatment with tissue-plasminogen activator failed to lyse the obstruction, we performed intracoronary catheter-aspiration embolectomy via a transradial approach, which yielded a favorable result...
  100. ncbi Systemic embolism: a serious complication after cardiac transplantation avoidable by bicaval technique
    A Riberi
    Department of Cardiovascular Surgery, Children s Hospital La Timone, Rue de l Armée d Afrique, 13385, Cedex 5, Marseille, France
    Eur J Cardiothorac Surg 19:307-11; discussion 311-2. 2001
    Systemic embolism is a serious complication after classical orthotopic transplantation, presumably originating from enlarged left atrium. We specifically studied this problem after classical and modified bicaval transplantation.

Research Grants75

  1. Right ventricular contractile dysfunction after pressure overload
    CLIFFORD RUSSELL GREYSON; Fiscal Year: 2013
    ..pulmonary hypertension is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation, but ..
  2. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
    ..to the pathogenesis of common clinical disorders such as myocardial infarction, deep vein thrombosis, pulmonary embolism, and stroke...
  3. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2012
    ..Nearly 576,000 new cases of deep vein thrombosis and pulmonary embolism, two of the most common thrombotic conditions, are diagnosed every year in the US alone...
  4. PlGF-HIF1a-miRNA Axis in Sickle Pulmonary Hypertension
    Punam Malik; Fiscal Year: 2013
    ..likely multi-factorial, potentiated by hemolysis-induced impaired nitric oxide bioavailability, chronic thrombo-embolism from a procoagulant state, and increased endothelin-1 (ET-1)...
  5. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    ..of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  6. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    ..Thrombus is implicated in a range of pathologies, e.g. ischemic stroke, myocardial infarction, pulmonary embolism, and deep vein thrombosis...
  7. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    ..inciting event leading to acute lung injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema, all of which lead to clinically significant respiratory failure but for which ..
  8. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2013
    ..of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke')...
  9. Anti-Phospholipid Multiplex For Pathologic Epitopes
    Paul O Neilsen; Fiscal Year: 2010
    ..S. patients each year. Primary APS in some severe cases leads to death via emergency venous thrombosis/embolism;and secondary APS compounds other autoimmune diseases such as lupus and venous thromboembolism...
  10. Systemic Application for Injury Site Specific Delivery via Neutrophils to Treat B
    XUDONG J LI; Fiscal Year: 2013
    ..include, but are not limited to, epidural hematoma, epidural infection, nerve root injury, dural puncture, air embolism and vasovagal syncope. Moreover, the epidural injection is technically demanding...
  11. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
    ..Along with the potentially fatal complication of pulmonary embolism, DVT frequently leads to a significant long- term complication for which we have no specific therapy, post-..
  12. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..According to the Surgeon General's 2008 Call to Action to Prevent Deep Venous Thrombosis and Pulmonary Embolism, over 300,000 Americans each year suffer from venous thromboembolism (VTE), with potentially over 100,000 ..
  13. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism
    Jeffrey A Kline; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Current standard treatment for acute pulmonary embolism (PE) focuses on anticoagulation to reduce clot extension...
  14. Structural and Biochemical Basis of the Vitamin K cycle
    Weikai Li; Fiscal Year: 2013
    ..used oral anticoagulant for treating and preventing thrombosis diseases including deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction. Warfarin has a narrow therapeutic window due to the high risk of hemorrhage...
  15. High throughput assay for fibrin-binding probes
    PETER D CARAVAN; Fiscal Year: 2013
    ..g. ischemic stroke, myocardial infarction, pulmonary embolism, and deep vein thrombosis...
  16. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy
    Everette C Burdette; Fiscal Year: 2012
    ..e., atelectasis and pneumonia, deep venous thrombosis and pulmonary embolism. Surgical options are not possible for all patients, but when indicated, they consist of heavy interventions such ..
  17. Genetic and Environmental Risk Factors for Venous Thromboembolism
    Christopher Kabrhel; Fiscal Year: 2013
    ..of the United States who in 2008 issued a 'Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism'urging "more research on the causes, prevention, and treatment of deep vein thrombosis...
  18. Computer-Aided Detection of Pulmonary Embolism on CT Pulmonary Angiography
    Chuan Zhou; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pulmonary embolism (PE) is one of leading cause of death in the United States if untreated. Prompt diagnosis and treatment can dramatically reduce the mortality rate and morbidity of the disease...
  19. Novel Methods for Dissolving Blood Clots
    GUY LELAND REED; Fiscal Year: 2013
    ..VTEs are blood clots in the legs (venous thrombosis) that may travel to the lungs (pulmonary embolism). It is estimated that 10-20% of VTE patients die, and the annual direct costs are up to $10 billion...
  20. Identifying novel genetic risk factors for venous thromboembolism (VTE)
    Jun Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep vein thrombosis (DVT) and pulmonary embolism (PE), collectively referred to as venous thromboembolism (VTE), is the third most common cause of vascular death in the US, after only heart attacks ..
  21. Clinical Trial Planning Grant in Catheter-Directed Thrombolysis of Occlusive DVT
    Marilyn J Manco-Johnson; Fiscal Year: 2013
    ..States (US) Surgeon General's Call-to-Action on Prevention of Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE) emphasized chronic venous insufficiency following DVT as an important priority for future investigation...
  22. Antithrombotic Aptamers and Antidotes
    BRUCE ALAN SULLENGER; Fiscal Year: 2013
    ..including acute coronary syndromes (myocardial infarction and unstable angina), deep vein thrombosis, pulmonary embolism, and peripheral vascular disease...
  23. Anatomic Risk Factors for Venous Thromboembolism
    ANAND KUMAR NARAYAN; Fiscal Year: 2010
    ..When thrombi form and then break off, they can travel to the lungs, a condition known as pulmonary embolism, which represents leading cause of preventable death in the United States...
  24. Microvesicle production after trauma &its Clinical Impact on Venothromboembolism
    Myung S Park; Fiscal Year: 2013
    ..such as deep leg clots (also known as deep vein thrombosis) or clots lodged in the lung (also known as pulmonary embolism), collectively known as venous thromboembolism...
  25. Sensitive Measurement of Cardiac Troponin I at Point of Care: The Silicon BioDevi
    OCTAVIAN FLORESCU; Fiscal Year: 2012
    ..important, the system will be able to measure a myriad of other biomarkers for heart failure, pulmonary embolism and deep vein thrombosis, sepsis and other conditions where speed, convenience and in the field measurement of ..
  26. Stroke and aPL: Community-Based Clinicopathological Study
    STEVEN RICHARD LEVINE; Fiscal Year: 2012
    ..baseline aPL to be an independent risk factor for: (a) venous blood clots (deep venous thrombosis and pulmonary embolism) in men (Physicians Health Study) (Ginsburg et al 1992), (b) MI and stroke in men (Honolulu Heart Study) (Brey et ..
  27. Ultrasound assisted thrombolysis for acute pulmonary embolism
    CURTIS GENSTLER; Fiscal Year: 2012
    ..including rt-PA, for catheter-directed thrombolysis of Deep Vein Thrombosis (DVT) and Massive Acute Pulmonary Embolism (PE). Chamsuddin et al...
  28. The Incidence and Progression of Peripheral Venous Disease
    Michael H Criqui; Fiscal Year: 2010
    ..We will separately determine the incidence of venous thrombosis and pulmonary embolism. Second, to evaluate risk factors for incident/progressive venous disease, focusing on risk factors potentially ..
  29. Platelet adhesion to neutrophil extracellular DNA traps: role in thrombosis
    Denisa D Wagner; Fiscal Year: 2013
    ..We will study NETs as biomarkers in thrombosis. Thrombosis, including deep vein thrombosis/pulmonary embolism is now the biggest killer in the United States...
  30. Griffin: Venous Thromboembolism and mass spectrometry-based untargeted metabolomi
    JOHN H contact GRIFFIN; Fiscal Year: 2010
    ..7. Public Health Relevance: Deep vein thrombosis and pulmonary embolism (VTE) in the USA annually result in 500,000 hospitalizations and >50,000 deaths...
  31. Blood Transfusions: Gender Differences in Utilization, Predictors, and Outcomes
    Mary A M Rogers; Fiscal Year: 2010
    ..Information regarding blood transfusion, infection, and thrombotic events (deep-vein thrombosis, pulmonary embolism, transient ischemic attack, stroke, and myocardial infarction) will be extracted from CMS files...
  32. EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISM
    Aaron R Folsom; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Venous thromboembolism (VTE), comprising deep venous thrombosis and pulmonary embolism, is a major contributor to morbidity and mortality in the U.S...
  33. Predictive optimal anticlotting treatment for segmented patient populations
    Peter J Tonellato; Fiscal Year: 2013
    ..Anticlotting drugs reduce risk to thrombosis and treat conditions that might lead to stroke, pulmonary embolism, deep vein thrombosis or other blood clotting related disease...
  34. The Role of CaSR and GABA-B-R in Neuronal Responses to Ischemic Brain Injury
    Wenhan Chang; Fiscal Year: 2013
    ..applicant): Ischemic brain injury causes death and long-term disability in patients who suffer cardiac arrest and embolism stroke in the United States and in our VA community...
  35. Prevention and management of perioperative pulmonary embolism
    Vladimir R Muzykantov; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pulmonary embolism (PE) is a common post-surgical complication for which management is suboptimal...
  36. Microparticle Docking in Pancreatic Cancer Induced VTE
    Julia E Geddings; Fiscal Year: 2013
    ..thromboembolism (VTE) is a clinical term which refers to the development of deep vein thrombosis and pulmonary embolism. Pancreatic cancer patients have a high rate of VTE but the mechanism of VTE initiation and propagation has not ..
  37. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
    ..host of thrombotic complications including recurrent pregnancy losses, stroke, deep vein thrombosis and pulmonary embolism. The placental anticoagulant protein, annexin A5 (AnxAS) is a potent phospholipid (PL)-binding protein that forms ..
  38. A novel mechanism of coagulation in sickle cell disease
    JULIA BRITTAIN; Fiscal Year: 2012
    ..There also may be increased incidence of pulmonary embolism in SCD and histopathologic studies have suggested that large vessel narrowing with superimposed thrombosis is the ..
  39. Cerebral Autoregulation Monitoring to Reduce Brain Injury from Cardiac Surgery
    OLA ARVID SELNES; Fiscal Year: 2013
    Brain injury during cardiac surgery results primarily from cerebral embolism and/or reduced cerebral blood flow (CBF)...
  40. DEVELOPMENT OF A FIRST-IN-CLASS TARGETED FIBRINOLYTIC FOR POST-SURGICAL THROMBOPR
    Ronald Carnemolla; Fiscal Year: 2013
    ..in patients in the first hours after elective surgery for prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE)...
  41. Activation of encrypted tissue factor during thrombus formation in vivo
    CAMERON TRENOR; Fiscal Year: 2012
    ..Major causes of death, including stroke, heart attack and pulmonary embolism, are each linked to pathologic thrombosis...
  42. MION for Synchronized MRI and Drug Therapy of Brain Tumor
    Victor C Yang; Fiscal Year: 2010
    ..Optimized magnetic field topography will then follow to abort possible embolism of arterial vasculature and maximize tumor targeting selectivity...
  43. BRIDGE TRIAL
    Victor Hasselblad; Fiscal Year: 2013
    ..Primary efficacy outcome is arterial thromboembolism (stroke, TIA, or systemic embolism), and primary safety outcome is major bleeding (symptomatic, clinically-overt, or fatal)...
  44. BRIDGE TRIAL
    Thomas L Ortel; Fiscal Year: 2013
    ..Primary efficacy outcome is arterial thromboembolism (stroke, TIA, or systemic embolism), and primary safety outcome is major bleeding (symptomatic, clinically-overt, or fatal)...
  45. The Biochemistry and Physiology of Platelet TFPI
    SUSAN ANTONE MARONEY; Fiscal Year: 2013
    ..intravascular thrombosis that can result in common and severe diseases such as heart attack, stroke and pulmonary embolism. The long term goal of our proposed studies is to understand the role of TFPI produced by megakaryocytes and ..
  46. Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism
    Kyongtae T Bae; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism Abstract Venous thromboembolism (VTE), which clinically manifests as deep vein thrombosis (DVT) and pulmonary embolism ..
  47. Atrial Fibrillation Precursors May Be Novel Stroke Risk Factors
    Hooman Kamel; Fiscal Year: 2013
    ..Secondary analyses will compare biomarkers of cardiac embolism between the two groups, and correlate rates of supraventricular ectopy with these biomarkers...
  48. Regional Lung Mechanics by 3D Image Registration
    Joseph M Reinhardt; Fiscal Year: 2010
    ..Pulmonary disease processes, including emphysema, interstitial fibrosis, cancer, pulmonary embolism, acute lung injury and more, alter the material properties of lung tissue and change the mechanics of the ..
  49. Does screening variability make DVT an unreliable quality measure of trauma care?
    Elliott R Haut; Fiscal Year: 2012
    ..yet may be completely asymptomatic until the clot embolizes and causes sudden death from massive pulmonary embolism. Duplex ultrasound serves an important role as a noninvasive diagnostic tool for DVT detection...
  50. Determinants of Venous Thromboembolism in Older People
    Robert J Glynn; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Venous thromboembolism (VTE), including both pulmonary embolism and deep vein thrombosis, is an age related condition with potentially catastrophic clinical consequences...
  51. Estrogens and pharmacogenetic risks of venous thrombosis in postmenopausal women
    Nicholas L Smith; Fiscal Year: 2012
    ..30 to 89 years of age who experienced an incident VT, either deep vein thrombosis or fatal or non-fatal pulmonary embolism. This application will support the identification and the abstraction of medical record data VT cases and their ..
  52. Development of biomimetic oligomers as anticoagulant antagonists
    Richard W Scott; Fiscal Year: 2010
    LMWHs are being used with greater frequency to treat deep vein thrombosis, unstable angina, and acute pulmonary embolism, as well as thromboprophylaxis agents in a wide range of clinical situations including orthopedic surgery, high risk ..
  53. Role of Lipoprotein Receptors in Venous Thrombosis
    Dudley K Strickland; Fiscal Year: 2013
    ..Deep venous thrombosis (DVT) is a significant clinical problem that can also lead to potentially fatal pulmonary embolism. Clinical studies reveal that thrombus resolution is central to the pathogenesis of post- thrombotic syndrome...
  54. Long Circulating Low Molecular Weight Heparins Pulmonary
    Fakhrul Ahsan; Fiscal Year: 2006
    ..Venous thromboembolism may manifest as deep vein thrombosis or pulmonary embolism. Fatality from a pulmonary embolism may occur within a few minutes of the onset of symptoms...
  55. Glycomics of Heart and Lung Disease in the Genomic Era
    Muredach P Reilly; Fiscal Year: 2013
    ..These include acute myocardial infarction (AMI), coronary artery disease, venous thrombo-embolism, as well as multiple cardiopulmonary biomarkers traits such as circulating levels of VonWillebrand factor (VWF), ..
  56. Outpatient Treatment of Low-Risk Patients with Pulmonary Embolism
    Donald M Yealy; Fiscal Year: 2010
    Description (provided by applicant): Pulmonary embolism (PE) affects many, with an estimated incidence of up to 69 cases per 100,000 persons annually. In the U.S...
  57. Haemophilus parainfluenzae and cardiopulmonary disease
    Wade A Nichols; Fiscal Year: 2010
    ..H. parainfluenzae IE has been associated with a high frequency of septic embolism in which vegetative masses, comprising bacteria and platelets, break off from the main site of infection and ..
  58. The Risk of Paradoxical Embolism (ROPE) Study
    David M Kent; Fiscal Year: 2012
    ..This suggests that paradoxical embolism (PE), venous emboli that access the arterial circulation via a PFO, is a major cause of CS...
  59. Venous thromboembolism among California cancer patients
    Helen Chew; Fiscal Year: 2003
    Venous thromboembolism (VTE, includes both venous thrombosis and pulmonary embolism) is a frequent complication among patients with cancer...
  60. Image-Guided Non-Invasive Ultrasonic Thrombolysis Using Histotripsy
    Zhen Xu; Fiscal Year: 2012
    ..to other clinical conditions requiring thrombolysis, including stroke, superficial vein thrombosis, pulmonary embolism, and dialysis graft thrombosis...
  61. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX II
    CHARLES HALES; Fiscal Year: 2003
    ..predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal...
  62. Functional roles of atrial-specific ion channels in the heart
    Nipavan Chiamvimonvat; Fiscal Year: 2013
    ..is the most common atrial arrhythmia affecting veteran population, and is associated with a significant risk of embolism and stroke...
  63. LMWH for Post-partum Prophylaxis in Women at Risk of Venous Thrombosis
    Marc Rodger; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pulmonary embolism (PE), the most serious form of venous thromboembolism (VTE), is a leading cause of maternal mortality in the developed world...
  64. Integrated Multifunctional Imaging of Deep Vein Thrombosis
    Walter Scott; Fiscal Year: 2009
    Deep venous thrombosis (DVT), and its sequelae, pulmonary embolism (PE), is a significant clinical problem, representing the leading cause of preventable in-hospital mortality in the USA and other developed countries...
  65. Cost Effectiveness of Anticoagulation Versus Genetic Testing of CYP2C9 & VKORC1 G
    Anna Teschemaker; Fiscal Year: 2009
    ..criteria including patient age >18 years, confirmed clinical diagnosis of deep venous thrombosis or pulmonary embolism, warfarin therapy prescribed for at least 6 months, and an indication for target INR between 2 to 3...
  66. INFERIOR VENA CAVA FILTRATION WITH A REMOVABLE DEVICE
    Elvira Lang; Fiscal Year: 1999
    ..adapted from applicant's abstract): A removable inferior vena cava filter will be developed to prevent pulmonary embolism in patients who are temporarily at risk to develop this life-threatening complication...
  67. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    Echocardiography can help risk-stratify the severity of pulmonary embolism (PE) diagnosed in normotensive patients. However, because echocardiography is not uniformly available in U.S...
  68. Identifying Low-Risk Patients with Pulmonary Embolism
    Drahomir Aujesky; Fiscal Year: 2005
    Pulmonary embolism (PE) is a common, costly, and potentially lethal disease in the US...
  69. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2006
    ..RV pressure overload is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation...
  70. ORAL CONTRACEPTIVES AND THROMBOEMBOLIC DISEASE
    Stephen Sidney; Fiscal Year: 2000
    ..a) the relative and attributable risk of venous thromboembolic disease (deep venous thrombosis and pulmonary embolism) in current users of low-dose (<50 micrograms estrogen) oral contraceptive (OC) preparations; and b) the ..
  71. Thrombin Formation Inhibitors
    James Phillips; Fiscal Year: 2004
    ..dangers of DVT is that part of the clot may break off and travel to the heart and lungs promoting a pulmonary embolism (PE). There are approximately 5 million cases of DVT per year in United States with 600,000 cases of PE...
  72. Antithrombotic Activity of Ascidian Glycosaminoglycans
    DOUGLAS TOLLEFSEN; Fiscal Year: 2004
    ..applicant) Heparin from porcine or bovine tissues is used to treat diseases such as venous thrombosis, pulmonary embolism, and coronary artery thrombosis...
  73. PROSPECTIVE INVESTIGATION OF PE DX-II
    Kenneth Leeper; Fiscal Year: 2003
    ..value of contrast enhanced spiral-computed tomography (spiral CT) scan for the diagnosis of acute pulmonary embolism (PE). PE is common, yet frequently undiagnosed and fatal...
  74. Novel Recombinant Anticoagulant Proteins
    TZE CHEIN WUN; Fiscal Year: 2005
    ..such as unstable angina, acute myocardial infarction, ischemic stroke, deep vein thrombosis, pulmonary embolism, disseminated intravascular coagulation, and peripheral vascular disease...
  75. Development of an antidote-controlled FIXa inhibitor
    Christopher Rusconi; Fiscal Year: 2004
    ..diseases including acute coronary syndromes (heart attacks and unstable angina), deep vein thrombosis, pulmonary embolism, and peripheral vascular disease...