Genomes and Genes
Summary: VASCULAR DISEASES that are associated with DIABETES MELLITUS.
Publications287 found, 100 shown here
- Insulin resistance, the metabolic syndrome, and complication risk in type 1 diabetes: "double diabetes" in the Diabetes Control and Complications TrialEric S Kilpatrick
Department of Clinical Biochemistry, Hull Royal Infirmary, Anlaby Road, Hull HU3 2JZ, UK
Diabetes Care 30:707-12. 2007..This study has examined whether these also were predictors of micro- and macrovascular complications in type 1 diabetic patients participating in the Diabetes Control and Complications Trial (DCCT)...
- Biochemistry and molecular cell biology of diabetic complicationsM Brownlee
Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
Nature 414:813-20. 2001..This integrating paradigm provides a new conceptual framework for future research and drug discovery...
- Intensive blood glucose control and vascular outcomes in patients with type 2 diabetesAnushka Patel
N Engl J Med 358:2560-72. 2008..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
- Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational studyI M Stratton
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
BMJ 321:405-12. 2000..To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes...
- 10-year follow-up of intensive glucose control in type 2 diabetesRury R Holman
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
N Engl J Med 359:1577-89. 2008..We conducted post-trial monitoring to determine whether this improved glucose control persisted and whether such therapy had a long-term effect on macrovascular outcomes...
- Diabetes and atherosclerosis: epidemiology, pathophysiology, and managementJoshua A Beckman
Leducq Center for Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
JAMA 287:2570-81. 2002..Complications of atherosclerosis cause most morbidity and mortality in patients with diabetes mellitus. Despite the frequency and severity of disease, proven medical therapy remains incompletely understood and underused...
- Advanced glycation end products: sparking the development of diabetic vascular injuryAlison Goldin
Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Circulation 114:597-605. 2006..Because of the emerging evidence about the adverse effects of AGEs on the vasculature of patients with diabetes, a number of different therapies to inhibit AGEs are under investigation...
- Glucose control and vascular complications in veterans with type 2 diabetesWilliam Duckworth
Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
N Engl J Med 360:129-39. 2009..The effects of intensive glucose control on cardiovascular events in patients with long-standing type 2 diabetes mellitus remain uncertain...
- Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studiesRachel Huxley
George Institute for International Health, University of Sydney, PO Box M201, Sydney, NSW 2050, Australia
BMJ 332:73-8. 2006..To estimate the relative risk for fatal coronary heart disease associated with diabetes in men and women...
- Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trialFaramarz Ismail-Beigi
Department of Medicine, Division of Clinical and Molecular Endocrinology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
Lancet 376:419-30. 2010..We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes...
- Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetesCindy J M Loomans
Department of Vascular Medicine and Diabetology, University Medical Center Utrecht, Utrecht, The Netherlands
Diabetes 53:195-9. 2004..We hypothesize that EPC dysfunction contributes to the pathogenesis of vascular complications in type 1 diabetes...
- Intensive glucose control and macrovascular outcomes in type 2 diabetesF M Turnbull
The George Institute for International Health, University of Sydney, Sydney, NSW 2050, Australia
Diabetologia 52:2288-98. 2009..The aim of these analyses was to generate more precise estimates of the effects of more-intensive, compared with less-intensive, glucose control on the risk of major cardiovascular events amongst patients with type 2 diabetes...
- Mortality and causes of death in the WHO Multinational Study of Vascular Disease in DiabetesN J Morrish
North Bedfordshire Diabetes Centre, Bedford Hospital, UK
Diabetologia 44:S14-21. 2001..The low excess mortality in the Japanese cohort could have implications for the possible reduction of the burden of mortality associated with diabetes in other parts of the world...
- Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetesS P Laing
Section of Epidemiology, Brookes Lawley Building, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
Diabetologia 46:760-5. 2003..The Diabetes UK cohort, essentially one of patients with Type 1 diabetes, now has sufficient follow-up to report all heart disease, and specifically ischaemic heart disease, mortality rates by age...
- Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery diseaseThomas Nystrom
Dept of Internal Medicine, Stockholm South Hospital, Karolinska Institute, Stockholm SE 118 83, Sweden
Am J Physiol Endocrinol Metab 287:E1209-15. 2004..This beneficial vascular effect of GLP-1 adds yet another salutary property of the peptide useful in diabetes treatment...
- NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and olderCharles M Alexander
Outcomes Research and Management, U S Medical and Scientific Affairs, Merck and Co, Inc, West Point, PA, USA
Diabetes 52:1210-4. 2003..However, individuals with diabetes without metabolic syndrome had no greater prevalence of CHD compared with those with neither...
- Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part IMark A Creager
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
Circulation 108:1527-32. 2003
- Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)Lars Ryden
Department of Cardiology, Karolinska University Hospital, Sweden
Eur Heart J 28:88-136. 2007
- Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitusGian Paolo Fadini
Department of Clinical and Experimental Medicine, Division of Metabolic Diseases, University of Padova, School of Medicine, Padova, Italy
J Am Coll Cardiol 45:1449-57. 2005..We sought to establish whether a reduction in endothelial progenitor cells (EPCs) has a putative role in peripheral vascular disease (PVD) of type 2 diabetic patients...
- Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studiesM Hanefeld
Centre for Clinical Studies, GWT, Technical University of Dresden, Fiedlerstrasse 34, 01307 Dresden, Germany
Eur Heart J 25:10-6. 2004..To assess if treatment with the alpha-glucosidase inhibitor acarbose can reduce cardiovascular events in type 2 diabetic patients...
- Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetesAino Soro-Paavonen
Albert Einstein Juvenile Diabetes Research Foundation Centre for Diabetes Complications, Diabetes Metabolism Division, Baker Heart Research Institute, Melbourne, Australia
Diabetes 57:2461-9. 2008..This study examines the effects of deletion of RAGE on the development of atherosclerosis in the diabetic apoE(-/-) model of accelerated atherosclerosis...
- Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproductsL Park
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Nat Med 4:1025-31. 1998....
- Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cellsXueliang Du
Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
J Clin Invest 112:1049-57. 2003..Elevated glucose increased poly(ADP-ribosyl)ation of GAPDH in WT aortae, but not in the aortae from PARP-1-deficient mice. Thus, inhibition of PARP blocks hyperglycemia-induced activation of multiple pathways of vascular damage...
- Coronary microvascular dysfunctionPaolo G Camici
Medical Research Council Clinical Sciences Centre Hammersmith Hospital, and National Heart and Lung Institute, Imperial College, London, United Kingdom
N Engl J Med 356:830-40. 2007
- Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetesSridevi Devaraj
Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, CA 95817, USA
Diabetes 55:774-9. 2006..These results have a major implication on our understanding of the role of inflammation in vasculopathies in type 1 diabetes...
- Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetesL Blonde
Ochsner Clinic Foundation, New Orleans, LA, USA
Diabetes Obes Metab 8:436-47. 2006..This analysis examined the effects of exenatide on glycaemic control and weight over an 82-week period in patients with DM2 unable to achieve adequate glycaemic control with sulphonylurea (SU) and/or metformin (MET)...
- Mortality trends in men and women with diabetes, 1971 to 2000Edward W Gregg
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3727, USA
Ann Intern Med 147:149-55. 2007..Whether mortality rates among diabetic adults or excess mortality associated with diabetes in the United States has declined in recent decades is not known...
- Skin autofluorescence is a strong predictor of cardiac mortality in diabetesRobbert Meerwaldt
Department of Medicine, University Medical Center Groningen, Groningen, Netherlands
Diabetes Care 30:107-12. 2007..The aim of the present study was to evaluate the relationship between skin autofluorescence and metabolic burden (hyperglycemia and hyperlipidemia) and its relationship with CHD and mortality...
- Determinants of vascular function in patients with type 2 diabetesKaterina K Naka
Michaelidion Cardiac Center, University of Ioannina, Ioannina, Greece
Cardiovasc Diabetol 11:127. 2012..The aim of our study was to investigate the predictors of vascular dysfunction in T2DM patients...
- Platelet indices in diabetes mellitus: indicators of diabetic microvascular complicationsSonali Jindal
Department of Pathology, Hindu Rao Hospital, Delhi, India
Hematology 16:86-9. 2011..This study was aimed at evaluating platelet indices in diabetic versus non-diabetic patients and assessing their utility as indicators of presence of complications in patients with DM...
- Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidaseGarry X Shen
Department of Internal Medicine, University of Manitoba, 835 715 McDermot Avenue, Winnipeg MB R3E 3P4, Canada
Can J Physiol Pharmacol 88:241-8. 2010....
- Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trialLawrence H Young
Yale University School of Medicine, Section of Cardiovascular Medicine, Department of Internal Medicine, New Haven, CT 06520, USA
JAMA 301:1547-55. 2009..Coronary artery disease (CAD) is the major cause of mortality and morbidity in patients with type 2 diabetes. But the utility of screening patients with type 2 diabetes for asymptomatic CAD is controversial...
- Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE projectR M Conroy
Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
Eur Heart J 24:987-1003. 2003..The SCORE project was initiated to develop a risk scoring system for use in the clinical management of cardiovascular risk in European clinical practice...
- Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetesC G Egan
Department of Neuroscience, University of Siena, Via A Moro, 53100, Siena, Italy
Diabetologia 51:1296-305. 2008..Since expression of chemokine (C-X-C motif) receptor 4 (CXCR4) has been associated with mobilisation and recruitment of progenitor cells, CXCR4 expression was also analysed...
- Diabetes and advanced glycation endproductsH Vlassara
Department of Geriatrics, Mount Sinai School of Medicine, NY 10029, USA
J Intern Med 251:87-101. 2002..The final disposal of AGE depends on renal clearance. Promising pharmacologic strategies to prevent AGE formation, reduce AGE toxicity, and/or inactivate AGE are under investigation...
- Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes--the EURODIAB Prospective Complications StudyM T Schram
Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
Diabetologia 48:370-8. 2005..The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes...
- Increased serum adiponectin levels in type 1 diabetic patients with microvascular complicationsJ Frystyk
Medical Research Laboratories, Clinical Institute and Medical Department M Diabetes and Endocrinology, Aarhus University Hospital, Aarhus C, Denmark
Diabetologia 48:1911-8. 2005..In type 1 diabetic patients, the relationship between ADPN and the presence of vascular complications is largely unknown...
- Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular diseaseC D A Stehouwer
Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
Diabetologia 51:527-39. 2008..New pharmacological strategies to reduce arterial stiffness are likely to be especially relevant to individuals with diabetes...
- Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetesJin Young Shin
Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Cardiovasc Diabetol 10:30. 2011..The purpose of this study is to investigate the relationship between FPG and arterial stiffness in non-diabetic healthy subjects...
- Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with Type 1 diabetes mellitus: relation to glycaemic control and microvascular complicationsF Chiarelli
Department of Medicine, University of Chieti, Italy
Diabet Med 17:650-6. 2000....
- Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitusAdriaan Kooy
Department of Internal Medicine and Bethesda Diabetes Research Center, RA Hoogeveen, The Netherlands
Arch Intern Med 169:616-25. 2009..We investigated whether metformin hydrochloride has sustained beneficial metabolic and (cardio) vascular effects in patients with type 2 diabetes mellitus (DM2)...
- Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complicationsSridevi Devaraj
Department of Pathology, Laboratory for Atherosclerosis and Metabolic Research, UCDavis Medical Center, Sacramento, CA 95817, USA
Diabetes 56:2790-6. 2007....
- Prognostic value of coronary artery calcium screening in subjects with and without diabetesPaolo Raggi
Section of Cardiology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
J Am Coll Cardiol 43:1663-9. 2004..The study was done to determine the interaction of coronary artery calcium and diabetes mellitus for prediction of all-cause death...
- Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathyHelen Vlassara
Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 99:15596-601. 2002..05). Thus in diabetes, environmental (dietary) AGEs promote inflammatory mediators, leading to tissue injury. Restriction of dietary AGEs suppresses these effects...
- Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic reviewDean T Eurich
Institute of Health Economics, Edmonton, AB, Canada, T5J 3N4
BMJ 335:497. 2007..To review the literature on the association between antidiabetic agents and morbidity and mortality in people with heart failure and diabetes...
- Higher plasma levels of advanced glycation end products are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up studyJohanna W Nin
Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
Diabetes Care 34:442-7. 2011....
- Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient micePaul Lewis
Oxidative Stress Group, JDRF Diabetes and Metabolism Division, Baker Heart Research Institute, PO Box 6492, St Kilda Rd Central, Melbourne, VIC 8008, Australia
Circulation 115:2178-87. 2007..We induced diabetes in mice deficient for both GPx1 and apolipoprotein E (ApoE) to determine whether this is merely an association or whether GPx1 has a direct effect on diabetes-associated atherosclerosis...
- Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathyN Zhang
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou China
Exp Clin Endocrinol Diabetes 116:104-11. 2008..These results show that MSCs transplantation improved cardiac function in the rat DCM model, possibly through angiogenesis and attenuation of cardiac remodeling...
- Endothelial dysfunction as a potential contributor in diabetic nephropathyTakahiko Nakagawa
Division of Renal Disease and Hypertension, University of Colorado Denver, 12700 East 19th Avenue, Aurora, CO 80045, USA
Nat Rev Nephrol 7:36-44. 2011..If endothelial dysfunction is the key factor required for diabetic nephropathy, then agents that improve endothelial function or raise intraglomerular nitric oxide level could be beneficial in the treatment of diabetic nephropathy...
- Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD studyFrans J Th Wackers
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Diabetes Care 27:1954-61. 2004..To assess the prevalence and clinical predictors of silent myocardial ischemia in asymptomatic patients with type 2 diabetes and to test the effectiveness of current American Diabetes Association screening guidelines...
- Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type 2 diabetesK Tanaka
Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima, Japan
Diabet Med 29:492-500. 2012..The aim of this study was to evaluate associations between skin autofluorescence and vascular complications in non-Caucasian patients with Type 2 diabetes...
- Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitusElizabeth Selvin
Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
Ann Intern Med 141:421-31. 2004..In persons with diabetes, chronic hyperglycemia (assessed by glycosylated hemoglobin level) is related to the development of microvascular disease; however, the relation of glycosylated hemoglobin to macrovascular disease is less clear...
- Diabetic nephropathy in 27,805 children, adolescents, and adults with type 1 diabetes: effect of diabetes duration, A1C, hypertension, dyslipidemia, diabetes onset, and sexKlemens Raile
Department of Pediatric Endocrinology and Diabetes, Charite Children s Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
Diabetes Care 30:2523-8. 2007..To give an up-to-date profile of nephropathy and the involvement of risk factors in a large, prospective cohort of patients with type 1 diabetes and largely pediatric and adolescent onset of disease...
- TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) studyS J Bielinski
Division of Epidemiology and Community Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA
Diabetologia 51:968-70. 2008..We hypothesised that TCF7L2 single nucleotide polymorphisms (SNPs) are associated with cardiovascular disease (CVD) and that the associations differ in diabetic and non-diabetic persons...
- Chronic kidney disease categories and renal-cardiovascular outcomes in type 2 diabetes without prevalent cardiovascular disease: a prospective cohort study (JDDM25)H Yokoyama
Jiyugaoka Medical Clinic, Internal Medicine, West 6, South 6 4 3, Obihiro 080 0016, Japan
Diabetologia 55:1911-8. 2012..Clarification of this relationship is important for clinical decision-making for both low- and high-risk diabetic patients...
- Role of oxidative stress in diabetes-mediated vascular dysfunction: unifying hypothesis of diabetes revisitedStephen W Schaffer
University of South Alabama, Department of Pharmacology, Mobile, AL 36688, USA
Vascul Pharmacol 57:139-49. 2012..The present review critiques the major premises of the hypothesis and concludes that further study of the role of oxidative stress in the development of diabetes-mediated vasculature dysfunction is warranted...
- HbA(1c) variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2A Sugawara
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 3 2 7 Miya machi, Mito, Ibaraki, Japan, 310 0015
Diabetologia 55:2128-31. 2012..4 mg/mmol (≥ 30 mg/g) in at least two of three consecutive urine samples in Japanese patients with type 2 diabetes...
- Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activationAzza B el-Remessy
College of Pharmacy, The University of Georgia, 1120 15th Street, HM 1200, Augusta, GA 30912, USA
Exp Diabetes Res 2010:247861. 2010..Together, peroxynitrite can suppress eNOS expression via activation of RhoA and hence cause vascular dysfunction...
- The rise and fall of HbA(1c) as a risk marker for diabetes complicationsE S Kilpatrick
Department of Clinical Biochemistry, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ, UK
Diabetologia 55:2089-91. 2012....
- Involvement of microparticles in diabetic vascular complicationsGala Tsimerman
Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
Thromb Haemost 106:310-21. 2011..This study demonstrates that MP characteristics are related to the specific type of vascular complications and may serve as a bio-marker for the pro- coagulant state and vascular pathology in patients with T2DM...
- Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidenceE Bonora
Division of Endocrinology and Metabolic Disease, University of Verona Medical School, Ospedale Maggiore, Piazzale Stefani 1, Verona, Italy
Diabetologia 44:2107-14. 2001..Trials specifically designed to address this issue are needed to determine whether postprandial hyperglycaemia plays an independent and causative role in cardiovascular disease in patients with Type II diabetes...
- Cerebral perfusion and aortic stiffness are independent predictors of white matter brain atrophy in type 1 diabetic patients assessed with magnetic resonance imagingSaskia G C van Elderen
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
Diabetes Care 34:459-63. 2011..To identify vascular mechanisms of brain atrophy in type 1 diabetes mellitus (DM) patients by investigating the relationship between brain volumes and cerebral perfusion and aortic stiffness using magnetic resonance imaging (MRI)...
- Type 2 diabetes is associated with increased pulse wave velocity measured at different sites of the arterial system but not augmentation index in a Chinese populationMinghua Zhang
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
Clin Cardiol 34:622-7. 2011..Moreover, the association between pulse wave velocity (PWV) and augmentation index (AIx) in diabetes is poorly understood...
- Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery diseaseCaterina Marciano
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
Eur J Nucl Med Mol Imaging 39:1199-206. 2012..We assessed the impact of type 2 diabetes, in the presence of other major cardiovascular risk factors, on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (CAD)...
- The impact of serum lipids on risk for microangiopathy in patients with type 2 diabetes mellitusPeter P Toth
CGH Medical Center, 101 East Miller Rd, Sterling, IL, 61081, USA
Cardiovasc Diabetol 11:109. 2012....
- Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null miceDe xiu Bu
Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Circ Res 106:1040-51. 2010..The multiligand RAGE (receptor for advanced glycation end products) contributes to atherosclerosis in apolipoprotein (Apo)E-null mice...
- Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crisesFrankie B Stentz
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Diabetes 53:2079-86. 2004..Return of these values to normal levels with insulin therapy demonstrates a robust anti-inflammatory effect of insulin...
- Tissue Doppler echocardiography in persons with hypertension, diabetes, or ischaemic heart disease: the Copenhagen City Heart StudyRasmus Mogelvang
Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
Eur Heart J 30:731-9. 2009..To test the hypothesis that echocardiographic tissue Doppler imaging (TDI) reveals reduced myocardial function in hypertension, diabetes, and ischaemic heart disease (IHD) in the general population...
- Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetesGian Paolo Fadini
Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
Circ Res 108:1112-21. 2011..Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in diabetes...
- Peripheral arterial disease in patients with diabetesSteven P Marso
Mid America Heart Institute, University of Missouri Kansas City, Saint Luke s Hospital, Kansas City, Missouri 64111, USA
J Am Coll Cardiol 47:921-9. 2006..This article will review the clinical implications of the consensus statement and highlight the treatment options available in order to help prevent future ischemic events in diabetic individuals with PAD...
- Vascular complications in diabetes mellitus: the role of endothelial dysfunctionCasper G Schalkwijk
Department of Internal Medicine, Academic Hospital Maastricht, The Netherlands
Clin Sci (Lond) 109:143-59. 2005..Finally, the components of the metabolic syndrome can impair endothelial function...
- Blood-derived angioblasts accelerate blood-flow restoration in diabetic miceG C Schatteman
Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52245, USA
J Clin Invest 106:571-8. 2000..Our findings suggest that CD34(+) cells may be a useful tool for therapeutic angiogenesis in diabetics...
- Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetesGang Hu
Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
Diabetes Care 28:799-805. 2005..The aim of this study was to examine both single and joint associations of physical activity and conventional cardiovascular risk factors with total and cardiovascular mortality among patients with diabetes...
- Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitusH L Lutgers
Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
Diabetologia 52:789-97. 2009..We investigated the prognostic value of skin autofluorescence for cardiovascular events in combination with the UKPDS risk engine in a cohort of patients with type 2 diabetes managed in primary care...
- Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT studyRobert S Elkeles
Endocrinology and Metabolic Medicine, Imperial College London, St Mary s Hospital, London, UK
Eur Heart J 29:2244-51. 2008..The PREDICT Study is a prospective cohort study designed to evaluate coronary artery calcification score (CACS) as a predictor of cardiovascular events in type 2 diabetes (T2DM)...
- Prevention and early detection of vascular complications of diabetesSally M Marshall
Diabetes Research Group, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
BMJ 333:475-80. 2006
- Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology FoundationJohn D Brunzell
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, and the Northwest Lipid Laboratory, University of Washington, Seattle, Washington, USA
Diabetes Care 31:811-22. 2008
- Receptor for advanced glycation endproducts (RAGE) and vascular inflammation: insights into the pathogenesis of macrovascular complications in diabetesThoralf Wendt
Division of Surgical Science, Department of Surgery, Columbia University College of Physicians and Surgeons, 630 West 168th Street, P and S 17 401, New York, NY 10032, USA
Curr Atheroscler Rep 4:228-37. 2002..Insights into therapeutic strategies to prevent or interrupt these processes are presented...
- Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formationR G Tilton
Department of Ophthalmology, Washington University School of Medicine, St Louis, MO 63110
Diabetes 42:221-32. 1993....
- Cardiovascular risk in women with diabetesA A Rivellese
Department of Clinical and Experimental Medicine, Federico II University of Naples, Napoli, Italy
Nutr Metab Cardiovasc Dis 20:474-80. 2010..To meet these needs gender specific guidelines and implementation measures may be in order...
- Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endotheliumHong Ding
School of Medical Sciences, RMIT University, BundooraWest Campus, Bundoora, Vic, Australia
Vasc Health Risk Manag 1:55-71. 2005..In addition, we consider the question of biomarkers for vascular disease and evaluate their usefulness for the early detection of and their role as contributors to vascular dysfunction...
- Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetesGian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy
Diabetes Care 33:1097-102. 2010..The present study was designed to describe the extent and potential mechanisms of progenitor cell reduction during the natural history of type 2 diabetes...
- Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatmentDominick J Angiolillo
Division of Cardiology, University of Florida, Shands Jacksonville, Jacksonville, Florida 32209, USA
J Am Coll Cardiol 48:298-304. 2006..This study sought to assess the influence of type 2 diabetes mellitus (T2DM) and the impact of hypoglycemic treatment (insulin vs. noninsulin) on platelet function profiles in patients treated with dual oral antiplatelet therapy...
- A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 studyDominick J Angiolillo
Division of Cardiology, University of Florida College of Medicine at Shands Jacksonville, Jacksonville, FL 32209, USA
Eur Heart J 29:2202-11. 2008..The aim of this pilot study was to assess the functional impact of cilostazol in T2DM patients on standard aspirin and clopidogrel treatment...
- Vascular targets of redox signalling in diabetes mellitusM M Spitaler
Department of Medical Biochemistry and Medical Molecular Biology, Karl Franzens University of Graz, Graz, Austria
Diabetologia 45:476-94. 2002..Thus, a better knowledge of the functional diversity and pathological consequences of each individual pathway activated by ROS id essential to understand the mechanisms of diabetes-associated vascular complications...
- Early detection of diabetic cardiomyopathy: usefulness of tissue Doppler imagingP Di Bonito
Department of Internal Medicine, Cardiology S Maria delle Grazie Pozzuoli Hospital, Naples, Italy
Diabet Med 22:1720-5. 2005....
- Carotid intima-media thickness and apolipoprotein B/apolipoprotein A-I ratio in middle-aged patients with Type 2 diabetesE M Dahlén
Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
Diabet Med 26:384-90. 2009..To explore the association between carotid intima-media thickness (IMT) and the apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio compared with conventional lipids in middle-aged patients with Type 2 diabetes...
- High-sensitivity C-reactive protein as cardiovascular risk marker in patients with diabetes mellitusAndreas Pfutzner
University of Applied Sciences, Rheinbach, Germany
Diabetes Technol Ther 8:28-36. 2006..Positive results in these trials will further strengthen the value and acceptance of hsCRP, which is recommended as a predictive laboratory marker for cardiovascular disease risk also in patients with diabetes mellitus...
- Costs of lower-extremity ulcers among patients with diabetesKaren Stockl
Prescription Solutions, 3515 Harbor Blvd, M S LC07 264, Costa Mesa, CA 92626, USA
Diabetes Care 27:2129-34. 2004..The objective of this study was to characterize health care costs associated with diabetic lower-extremity ulcers...
- Molecular targets of diabetic cardiovascular complicationsFatima K Ahmad
Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
Curr Drug Targets 6:487-94. 2005..However, clinical studies using these treatments have mainly yielded inconclusive results. The pathogenesis of diabetic vascular complications and results from animal studies and key clinical studies are reviewed here...
- Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tailDaniella Brasacchio
Epigenetics in Human Health and Disease Laboratory, The Alfred Medical Research and Education Precinct, Baker IDI Heart and Diabetes Institute, Victoria, Australia
Diabetes 58:1229-36. 2009..We have hypothesized that transient hyperglycemia mediates persistent gene-activating events attributed to changes in epigenetic information...
- Improved endothelial function with metformin in type 2 diabetes mellitusK J Mather
Division of Endocrinology and Metabolism, Indiana University, Indianapolis, USA
J Am Coll Cardiol 37:1344-50. 2001..This has important implications for the investigation and treatment of vascular disease in patients with type 2 diabetes mellitus...
- Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapySajoscha A Sorrentino
Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
Circulation 121:110-22. 2010..Moreover, in diabetic patients, we examined the impact of extended-release (ER) niacin therapy on the endothelial effects of HDL...
- Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemiaSuvi E Heinonen
Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, PO Box 1627, FI 70211, Kuopio, Finland
Circ Res 101:1058-67. 2007..In conclusion, type 2 diabetic factors induce increased calcification and lesion progression without any lipid changes in a new mouse model of diabetic macroangiopathy...
- Impact of diabetes mellitus on outcomes of superficial femoral artery endoluminal interventionsAndrew M Bakken
Center for Vascular Disease, Division of Vascular Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA
J Vasc Surg 46:946-958; discussion 958. 2007..We examined the consequences of endovascular treatment of the SFA in patients with and without DM...
- Arterial wall structure and dynamics in type 2 diabetes mellitus methodological aspects and pathophysiological findingsAlejandra I Christen
Hypertension Section, Metabolic Unit, Universitary Hospital Fundación Favaloro, Buenos Aires, Argentina
Curr Diabetes Rev 6:367-77. 2010..A complete understanding of the association between arterial alterations and early detection, and type 2 DM, may be critical for the primary prevention of DM-related macro-vascular disease...
- Association between hyper- and hypoglycaemia and 2 year all-cause mortality risk in diabetic patients with acute coronary eventsAnn Marie Svensson
Clinical Experimental Research Laboratory, Sahlgrenska University Hospital Ostra, 416 85 Goteborg, Sweden
Eur Heart J 26:1255-61. 2005....
- The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) studyJoseph DiChiara
Sinai Center for Thrombosis Research, Hoffberger Building, Suite 56, 2401 W Belvedere Ave, Baltimore, MD 21215, USA
Diabetes 56:3014-9. 2007..Diabetic patients may have a higher prevalence of platelet aspirin resistance than nondiabetic patients. Our goal was to analyze platelet aspirin responsiveness to various aspirin doses in diabetic and nondiabetic patients...
- Inflammation in obesity: Modulation by Weight LossParesh Dandona; Fiscal Year: 2009..abstract_text> ..
- HYPOXIA INDUCIBLE VEGF PRODUCTION IN SLEEP APNEAAndrew Levy; Fiscal Year: 2003....
- MACROPHAGE ACTIVATION AND LIPOPROTEIN METABOLISMMaria Lopes Virella; Fiscal Year: 2001..Our overall objective is to provide insight into the mechanisms by which anti-LDL antibodies and macrophage activation may contribute to the development(acceleration of the arteriosclerotic process. ..
- Defining the Clinical Significance of HbA1c Prior to the Onset of DiabetesElizabeth Selvin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Retinal Vascular Changes in Type 1 Diabetic African-AmericansMonique Roy; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Biomarkers in the progression of nephropathy in type 2DMJulie Lin; Fiscal Year: 2008..Data on how these modifiable biomarkers are related to kidney function decline could have an important and beneficial impact on treatment and monitoring of nephropathy in type 2 diabetes in the near future. [unreadable] [unreadable]..
- African American Study of Kidney Disease and Hypertensi*Robert Toto; Fiscal Year: 2007..Such results might eventually lead to new strategies that delay or prevent ESRD. ..
- Proatherogenic effect of thrombospondins in diabetesOLGA STENINA; Fiscal Year: 2005..abstract_text> ..
- ALPHA AND BETA CELL FUNCTION IN NORMAL AND DIABETIC MANJohn Gerich; Fiscal Year: 2007..Further knowledge of the control of renal glucose release could therefore have therapeutic implications for this disorder and in people with liver and kidney disease. [unreadable] [unreadable]..
- RISK FACTORS FOR DIABETIC RETINOPATHY IN BLACK AMERICANSMonique Roy; Fiscal Year: 2003..abstract_text> ..
- Adjuvant Therapy for Vascular Inflammation in DiabetesSushil Jain; Fiscal Year: 2006..abstract_text> ..
- TRAINING CURRICULUM IN PATIENT ORIENTED RESEARCHRobert Toto; Fiscal Year: 2004..The proposed program will provide young physicians and scientists with the skills needed to conduct clinical investigations and to compete for federal and non-federal research funding. ..
- Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic PatientsSushil K Jain; Fiscal Year: 2010..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
- Regulation of thrombospondin-1 expression by glucoseOlga I Stenina; Fiscal Year: 2010....
- Evaluating reasons for variations in LDL levelsP Ho; Fiscal Year: 2003..abstract_text> ..
- Predictors of Nephropathy in Type 2 DiabetesJulie Lin; Fiscal Year: 2008..D., Ph.D., a leading investigator in the field of nutritional epidemiology. This project proposal will provide the foundation for the candidate's future career as an independent and successful clinical scientist in renal research. ..
- Functional role of Angiopoietin-2 in diabetic heartJian xiong Chen; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- KININS ROLE IN MESANGIAL CELL FIBROSISAYAD JAFFA; Fiscal Year: 2005..abstract_text> ..
- Improving Outcomes in Diabetic NephropathyRobert Toto; Fiscal Year: 2008..PERFORMANCE SITE ========================================Section End=========================================== ..
- ORGANIZATIONAL CHARACTERISTICS AND CHRONIC DISEASE CAREPATRICK O CONNOR; Fiscal Year: 2001..Results will be relevant to policy makers, purchasers, health plans, medical groups, and clinics that are seeking to improve chronic disease care, and may suggest new intervention strategies worth further investigation. ..
- AGEs and cardiovascular disease in type 1 diabetesMark E Cooper; Fiscal Year: 2010..It is anticipated that these studies will ultimately lead to better strategies to treat and prevent diabetic vascular complications. ..
- Role of Erythrocytes in Circulatory ControlRandy Sprague; Fiscal Year: 2004..abstract_text> ..
- Mechanisms of ATP Release from RBC'sRandy Sprague; Fiscal Year: 2007..abstract_text> ..
- Molecular genetics of glucose homeostasis and fatDonald Bowden; Fiscal Year: 2009..g. create an "ultra high density" SNP map of the associated chromosomal region. These new SNPs will be genotyped on the IRASFS DNAs to identify the trait defining alleles. ..
- Comparative Effectiveness of Comprehensive Care for Adults with SMITODD PATRICK GILMER; Fiscal Year: 2010....
- Modifying obesogenic homes: Impact on weight maintenanceAmy Gorin; Fiscal Year: 2007..This home environmental approach, if successful, has potential applications to the maintenance of other important health behaviors. [unreadable] [unreadable]..
- PREMIER Maintenance Trial(MAINTENANCE)Laura Svetkey; Fiscal Year: 2007..The purpose of this proposal is to develop and test two such interventions, which, if effective, should complement ongoing efforts to stem the obesity epidemic and ultimately prevent obesity-related CVD. ..
- Comparative effectiveness of diabetes prevention strategies in women with GDMAssiamira Ferrara; Fiscal Year: 2010..Finding that this intervention is cost-effective in this setting should motivate its adoption at KP as well as in other health care systems. ..
- Lipolytic Mechanisms of PPAR ActivationJorge Plutzky; Fiscal Year: 2007..Through these programmatic efforts, insight will be gained into lipolysis as a mechanism for selective endogenous PPAR activation, and its distal transcriptional effects. ..
- Macrophage Cholesterol Metabolism and ApoE SynthesisTheodore Mazzone; Fiscal Year: 2007..abstract_text> ..
- Development of a tool to measure food availability in the homeJune Stevens; Fiscal Year: 2007..By accurately measuring what foods are in the home, we can learn how food availability influences diet. [unreadable] [unreadable] [unreadable]..
- Neurohormonal Blockade and Outcomes in Diastolic Heart FailureAli Ahmed; Fiscal Year: 2010..The proposed study will examine the effect of neurohormonal blockade in propensity matched OPTIMIZE-HF participants with diastolic heart failure. ..
- Egr-1, PKC Beta, Signalling and AtherosclerosisShi Fang Yan; Fiscal Year: 2009....
- Beta Cell Adaptation to Stress in Baboon Pancreas After Partial PancreatectomyFRANCO BATTISTA FOLLI; Fiscal Year: 2010....
- MIND-BODY-BEHAVIORAL MED CLINICAL TRIALS INFRASTRUCTUREKarina Davidson; Fiscal Year: 2008..The ultimate goal will be to make our findings available to 3 target audiences: 1) the network of investigators at Columbia; 2) the behavioral medicine community; and 3) the general medical community. ..
- Vascular risk after kidney transplantationJennifer L Larsen; Fiscal Year: 2010..The study will also provide preliminary evidence for the efficacy of Vitamin D and omega 3 fatty acid supplementation in modifying traditional and nontraditional CVD risk factors as well as CVD progression after KTX. ..
- GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELSJose M Ordovas; Fiscal Year: 2010..This evidence-based knowledge will contribute to a rational approach toward more effective dietary recommendations aimed to decrease health disparities and to a better CVD prevention. ..
- Inflammation and Injury in Obesity Hypertension in African American AdolescentsBonita Falkner; Fiscal Year: 2010..abstract_text> ..
- Inflammation & Prognosis in Decompensated Heart FailureGARY FELKER; Fiscal Year: 2008..Felker's development into an established independent clinical investigator with expertise in both complex clinical research methodology and the role of inflammation in the pathophysiology of heart failure. ..
- Hypertension Improvement Project (HIP)Laura Svetkey; Fiscal Year: 2008..3 for the primary outcome. The HIP study will test practical interventions for improving hypertension control that can be broadly implemented and reduce CVD risk. ..
- Adipocyte Lipid Metabolism and ApoE ExpressionTheodore Mazzone; Fiscal Year: 2009..For these studies, adipose tissue will be collected from the gluteal and abdominal subcutaneous regions, and from the intraperitoneal visceral region, of patients undergoing bariatric surgery;and utilized for isolation of adipocytes. ..
- Enhancing Exercise Participation in Overweight WomenJohn Jakicic; Fiscal Year: 2006..It is believed that this proposed study will lead to improvements in exercise participation in overweight women, which will result in improvements in the long-term treatment of obesity. ..
- GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRDBarry Freedman; Fiscal Year: 2001..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
- Leptin and insulin action in the brain; role in obesityKevin Niswender; Fiscal Year: 2007..These aims also provide the background and training necessary for the development of an independent research program and will be conducted in the context of rich training environment ..
- IMPAIRED CORONARY ARTERY FUNCTION IN INSULIN RESISTANCEDavid Busija; Fiscal Year: 2003..Findings from this project may provide important information that can be used in future studies to design treatments to prevent or abort the cardiovascular complications of insulin resistance. ..
- Obesity in early and middle adulthood and retirementJune Stevens; Fiscal Year: 2004..support researchers interested in undertaking secondary data analyses of data related to ... behavioral research on aging" and "... determinants of retirement .... " ..
- COLLAGEN CROSSLINKING BY THE MAILLARD REACTIOIN IN AGINGVincent Monnier; Fiscal Year: 2004..Our approach, we expect, will result in the first comprehensive, hierarchical map of collagen crosslinks that for, during aging. ..
- EFFECT OF DIABETES AND HYPERTENSION ON ISCHEMIC INJURYStephen Schaffer; Fiscal Year: 2003..Cell culture studies will be complimented by studies using an isolated heart model to test the hypothesis that hypertensive diabetic hearts will be more susceptible to an ischemic insole because of elevated levels of angiotensin. ..
- Cerebrovascular Dysfunction in Insulin ResistanceDavid Busija; Fiscal Year: 2004..We believe that our studies will result in new and important findings that will lead to improved therapies to reduce morbidity and mortality in IR individuals. ..
- CORTISOL, CENTRAL OBESITY, AND INSULIN RESISTANCEJonathan Purnell; Fiscal Year: 2003....
- Endogenous Mechanisms of PPAR ModulationJorge Plutzky; Fiscal Year: 2005..Together, these studies integrate biochemical, biologic, and in vivo models to better understand how endogenous modulation of PPAR activity may determine biologic responses. ..
- A MENTOR-BASED APPROACH TO LONG-TERM WEIGHT LOSSJohn Jakicic; Fiscal Year: 2001..It is believed that a mentor- based intervention will lead to improvements in the long-term treatment of obesity. ..
- Brain insulin and leptin resistance in obesityKevin Niswender; Fiscal Year: 2008..Aim 4: To determine if genetic enhancement of the hypothalamic PI3K pathway enhances insulin and leptin sensitivity and attenuates DIO. ..
- CAROTENOID BINDING PROTEIN AND CAROTENOID METABOLISMRaj Lakshman; Fiscal Year: 2002..2. Molecular biology techniques to measure CCBP mRNA levels in different tissues and to clone its cDNA. 3. HPLC procedures for quantification of various carotenoids and retinoids. ..
- HRQL Impact of Chronic Conditions and Comorbidity BurdenPatrick Sullivan; Fiscal Year: 2006..S. [unreadable] [unreadable]..
- KALLIKREINS-KININS AND DIABETIC VASCULAR COMPLICATIONSAYAD JAFFA; Fiscal Year: 2002..abstract_text> ..
- STUDY OF OSTEOPOROTIC FRACTURESTeresa Hillier; Fiscal Year: 2005....
- Androgens and Cardiovascular Risk in African AmericansBonita Falkner; Fiscal Year: 2005..The results of this project can contribute to the development of prevention and earlier intervention strategies, including more specific therapeutic targets, for this high-risk minority population. ..
- MECHANISMS OF ENDOTHELIAL DYSFUNCTION IN DIABETICSJoshua Beckman; Fiscal Year: 2003..abstract_text> ..
- ECONOMIC OUTCOMES OF TREATMENT STRATEGIES IN BAR1-2Mark Hlatky; Fiscal Year: 2006..The investigators further expect that this collaborative effort will translate into a new practical clinical paradigm that will be used for treatment of Type II diabetic patients. ..
- Collaborative Clinical Culture and Quality of CareSheldon Greenfield; Fiscal Year: 2003..The results of this study will provide insight into whether HCTs are associated with high staff morale and high quality of care. ..
- PHYSICIAN INTERVENTION TO IMPROVE DIABETES CAREPATRICK O CONNOR; Fiscal Year: 2002..The study will have substantial impact on clinical practice and policy whether the results are positive or negative. If successful, the interventions will be easily disseminated to other primary care practice settings. ..
- Poly(ADP-ribose) synthetase inhibition and diabetesCsaba Szabo; Fiscal Year: 2004....
- PARS and peroxynitrite induced cell deathCsaba Szabo; Fiscal Year: 2009..4 To establish the role of Bel family proteins in the regulation of calcium homeostasis during peroxynitrite-induced cell death. The studies proposed here have broad pathophysiological relevance. ..
- Mechanisms of Pro-Thrombosis in Diabetes MellitusDavid Schneider; Fiscal Year: 2003..Further, these results will define the importance of prothrombotic potential in diabetic subjects while potentially identifying new therapeutic targets in patients with diabetes and other insulin resistant states. ..
- C-Reactive Protein and Exercise in Postmenopausal WomenTimothy Church; Fiscal Year: 2003..These studies represent an innovative, unique, timely, and cost-effective opportunity to quickly explore the relation between CRP, physical activity, and HRT. ..
- RAGE and a Novel Tumor AxisAnn Schmidt; Fiscal Year: 2005....
- Effect of Exercise on Prevention of Weight GainJohn Jakicic; Fiscal Year: 2006..The results of this study will have a significant impact on exercise recommendations for preventing weight gain in adults. ..
- Reducing Clinical Inertia in Diabetes CarePATRICK O CONNOR; Fiscal Year: 2007..Results of this project will have significant clinical and policy implications. ..
- Poly(ADP-ribose)and diabetic erectile dysfunctionFANGMING ZUO; Fiscal Year: 2004..If these studies confirm that Inotek's PARP inhibitor is effective in improving erectile function in diabetes, a Phase II component will be triggered, which will focus on formal preclinical safety testing. ..
- Autonomic Function in Insulin Resistance and DiabetesMercedes Carnethon; Fiscal Year: 2005..abstract_text> ..
- Myicardial injury: role of poly (ADP-ribose) synthetaseCsaba Szabo; Fiscal Year: 2005..Further, based on exciting preliminary data, the final, fifth aim is focusing in establishing the role of PARS in myocardial preconditioning. ..
- DOSE-RESPONSE OF EXERCISE ON LONG-TERM WEIGHT LOSSJohn Jakicic; Fiscal Year: 2002..The investigators believe that the proposed study will lead to improvements in the long-term treatment of obesity. ..
- Novel preservation fluid for organ transplantationJon Mabley; Fiscal Year: 2003..abstract_text> ..
- Adenosine-3 agonists for the suppression of arthritisCsaba Szabo; Fiscal Year: 2003..A novel A3 receptor agonist may represent a useful anti-inflammatory adjunct to current therapeutic regimens; funding of the current SBIR Phase II will allow for starting human safety trials in 2 years. ..
- PARS INHIBITOR FOR THE THERAPY OF CIRCULATORY SHOCKLudmila Belayev; Fiscal Year: 2003..The current project will enable the applicants to move forward in two years, near to the level of the beginning of Phase II efficacy trial in septic patients. PROPOSED COMMERCIAL APPLICATION: Not Available ..
- Poly(ADP-ribose)Polymerase & Doxorubicin CardiotoxicityJon Mabley; Fiscal Year: 2002..PROPOSED COMMERCIAL APPLICATIONS: The annual anticipated revenues for an effective therapeutic to prevent anti-cancer-drug induced cardiodepression is over $100 million in the US alone. ..
- Mechanisms of cardiovascular dysfunction in diabetesCsaba Szabo; Fiscal Year: 2005..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..