multi infarct dementia

Summary

Summary: Loss of higher cortical functions with retained awareness due to multiple cortical or subcortical CEREBRAL INFARCTION. Memory, judgment, attention span, and impulse control are often impaired, and may be accompanied by PSEUDOBULBAR PALSY; HEMIPARESIS; reflex abnormalities, and other signs of localized neurologic dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p1060)

Top Publications

  1. ncbi The validity and reliability of chinese frontal assessment battery in evaluating executive dysfunction among Chinese patients with small subcortical infarct
    Vincent C T Mok
    Departments of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Alzheimer Dis Assoc Disord 18:68-74. 2004
  2. ncbi [Japanese CADASIL case with limited dementia who had the Notch 3 R141C mutation]
    Kenichi Ishibashi
    Department of Neurosurgery, Graduate School of Medicine, Osaka City University
    No To Shinkei 57:415-8. 2005
  3. ncbi [Analysis of complex segregation in a large family with hereditary cerebrovascular disease in Antioquia, Colombia]
    F Lopera
    Universidad de Antioquia, Programa de Neurociencias, Colombia
    Rev Neurol 32:222-5. 2001
  4. ncbi The vascular lesions in vascular and mixed dementia: the weight of functional neuroanatomy
    Dina Zekry
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, INSERM U 106 and 360, Association Claude Bernard, Pierre et Marie Curie University, Paris, France
    Neurobiol Aging 24:213-9. 2003
  5. pmc Cognitive impairment and functional outcome after stroke associated with small vessel disease
    V C T Mok
    Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Neurol Neurosurg Psychiatry 75:560-6. 2004
  6. ncbi Effect of acetaminophen on behavior, well-being, and psychotropic medication use in nursing home residents with moderate-to-severe dementia
    John T Chibnall
    Department of Psychiatry, School of Medicine, Saint Louis University, St Louis, Missouri 63104, USA
    J Am Geriatr Soc 53:1921-9. 2005
  7. ncbi Reduced neuropsychological test performance in asymptomatic carotid stenosis: The Tromsø Study
    E B Mathiesen
    Institutes of Community Medicine, University of Tromsø, Department of Neurology, University Hospital of North Norway, Tromsø, Norway
    Neurology 62:695-701. 2004
  8. pmc Forgetting in dementia with and without subcortical lacunes
    Joel H Kramer
    San Francisco Medical Center, University of California, CA 94143, USA
    Clin Neuropsychol 18:32-40. 2004
  9. ncbi An Italian case of CADASIL with mutation CGC-TCG in codon 1006, exon 19 Notch3 gene
    D Guidetti
    Division of Neurology, Santa Maria Nuova Hospital, Viale Risorgimento 80, I 42100, Reggio Emilia, Italy
    Neurol Sci 24:401-6. 2004
  10. ncbi [Vascular dementia]
    H J Gertz
    Klinik und Poliklinik fur Psychiatrie, Universitat Leipzig, Liebigstrasse 22, 04103 Leipzig
    Nervenarzt 73:393-404. 2002

Research Grants

  1. MENTAL ILLNESS IN THE ELDERLY--DIAGNOSTIC TESTING
    Andrew Leuchter; Fiscal Year: 1999
  2. PET AND MRI IMAGING OF PERSISTENT LYME ENCEPHALOPATHY
    Brian Fallon; Fiscal Year: 2003
  3. ERPS AND VERBAL MEMORY IN AGING DEMENTIA AND AMNESIA
    John Olichney; Fiscal Year: 1999
  4. CONNECTIONIST MODELING IN THE NEUROLOGY OF AGING
    WILLIAM LYTTON; Fiscal Year: 1991
  5. ALTERED CALCIUM HOMEOSTASIS TO DIAGNOSE ALZHEIMER'S
    Christine Peterson; Fiscal Year: 1992
  6. MANAGEMENT OF RESISTANCE TO BATHING ACTIVITIES
    Carol Mitchell; Fiscal Year: 1992
  7. ALZHEIMERS DISEASE CENTER
    Paul Coleman; Fiscal Year: 2000
  8. AIDS-Related Neurotoxicity and Novel NMDAR Antagonists
    Stuart Lipton; Fiscal Year: 2009
  9. Caspase Cleavage of MEF2 Mediates Neuronal Apoptosis
    Stuart Lipton; Fiscal Year: 2007
  10. ERYTHROPOIETIN-INDUCED NEUROPROTECTION
    Stuart Lipton; Fiscal Year: 2005

Detail Information

Publications217 found, 100 shown here

  1. ncbi The validity and reliability of chinese frontal assessment battery in evaluating executive dysfunction among Chinese patients with small subcortical infarct
    Vincent C T Mok
    Departments of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Alzheimer Dis Assoc Disord 18:68-74. 2004
    ..We studied the properties of a Chinese version of FAB (CFAB) in evaluating executive dysfunction among Chinese stroke patients with small subcortical infarct...
  2. ncbi [Japanese CADASIL case with limited dementia who had the Notch 3 R141C mutation]
    Kenichi Ishibashi
    Department of Neurosurgery, Graduate School of Medicine, Osaka City University
    No To Shinkei 57:415-8. 2005
    ..Here, we report a Japanese CADASIL case who displayed limited dementia and had the Notch 3 R141C mutation. The relationship between pathogenesis and the mutation site in Notch 3 is discussed based on the case presented here...
  3. ncbi [Analysis of complex segregation in a large family with hereditary cerebrovascular disease in Antioquia, Colombia]
    F Lopera
    Universidad de Antioquia, Programa de Neurociencias, Colombia
    Rev Neurol 32:222-5. 2001
    ..In this family the parameter calculated, autosomal dominant model, and clinical feature strongly support the diagnostic of CADASIL, linkage analysis and sequentiation will be performed to determinate if mutant gene is Notch3...
  4. ncbi The vascular lesions in vascular and mixed dementia: the weight of functional neuroanatomy
    Dina Zekry
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, INSERM U 106 and 360, Association Claude Bernard, Pierre et Marie Curie University, Paris, France
    Neurobiol Aging 24:213-9. 2003
    ..It may be useful for developing neuropathological criteria in multi-infarct and mixed dementias...
  5. pmc Cognitive impairment and functional outcome after stroke associated with small vessel disease
    V C T Mok
    Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Neurol Neurosurg Psychiatry 75:560-6. 2004
    ..We aimed to evaluate the frequency of the varying severity levels of cognitive impairment, the determinants of severe cognitive impairment, and the association of cognitive impairment with functional outcome after SSVD...
  6. ncbi Effect of acetaminophen on behavior, well-being, and psychotropic medication use in nursing home residents with moderate-to-severe dementia
    John T Chibnall
    Department of Psychiatry, School of Medicine, Saint Louis University, St Louis, Missouri 63104, USA
    J Am Geriatr Soc 53:1921-9. 2005
    ..To evaluate the effect of regularly scheduled administration of analgesic medication on behavior, emotional well-being, and use of as-needed psychotropic medications in nursing home residents with moderate-to-severe dementia...
  7. ncbi Reduced neuropsychological test performance in asymptomatic carotid stenosis: The Tromsø Study
    E B Mathiesen
    Institutes of Community Medicine, University of Tromsø, Department of Neurology, University Hospital of North Norway, Tromsø, Norway
    Neurology 62:695-701. 2004
    ..To assess the relationship between asymptomatic carotid stenosis, neuropsychological test performance, and silent MRI lesions...
  8. pmc Forgetting in dementia with and without subcortical lacunes
    Joel H Kramer
    San Francisco Medical Center, University of California, CA 94143, USA
    Clin Neuropsychol 18:32-40. 2004
    ..Three SIVD patients with rapid forgetting followed to autopsy all had AD pathology, further supporting the link between memory patterns and AD...
  9. ncbi An Italian case of CADASIL with mutation CGC-TCG in codon 1006, exon 19 Notch3 gene
    D Guidetti
    Division of Neurology, Santa Maria Nuova Hospital, Viale Risorgimento 80, I 42100, Reggio Emilia, Italy
    Neurol Sci 24:401-6. 2004
    ..The mutation led to a gain of a cysteine residue. This is the first missense mutation in codon 1006 of exon 19 of the Notch3 gene to be described in Italy and the second reported in the literature...
  10. ncbi [Vascular dementia]
    H J Gertz
    Klinik und Poliklinik fur Psychiatrie, Universitat Leipzig, Liebigstrasse 22, 04103 Leipzig
    Nervenarzt 73:393-404. 2002
    ..Estimates of the prevalence depend highly on the set of criteria used. Hence, they differ considerably...
  11. ncbi [Vascular dementia and mixed dementia]
    Dina Zekry
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, Paris 75
    Presse Med 36:1469-76. 2007
    ..Preventive therapeutic interventions include control of vascular risk factors and especially treatment of hypertension...
  12. ncbi [Screening for neuropsychological deficits--a screening test also for dementias?]
    C J G Lang
    Neurologische Klinik, Friedrich Alexander Universitat Erlangen Nurnberg
    Nervenarzt 73:434-41. 2002
    ..The advantage of NDS thus lies in the diversity of functions assessed, while its screening power is comparable to the two other tests used for comparison...
  13. ncbi De novo mutation in the Notch3 gene causing CADASIL
    A Joutel
    INSERM U25, Faculte de Medecine Necker Enfants Malades, and Hopital Lariboisière, Paris, France
    Ann Neurol 47:388-91. 2000
    ..Therefore, our finding suggests that CADASIL may be more frequent than anticipated...
  14. pmc The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients
    A Joutel
    INSERM U25, Faculte de Medecine Necker Enfants Malades, Paris 75730, France Laboratoire de Cytogénétique, Hopital Lariboisiere, Paris 75010, France
    J Clin Invest 105:597-605. 2000
    ..These results strongly suggest that CADASIL mutations specifically impair the clearance of the Notch3 ectodomain, but not the cytosolic domain, from the cell surface...
  15. pmc A 52-year-old man with cognitive decline, seizure and stroke
    Jessica E Simon
    Calgary Stroke Program, University of Calgary, Alberta
    CMAJ 170:1393-4. 2004
  16. ncbi Presenile dementia--etiology, clinical profile and treatment response at four month follow up
    U Sundar
    Department of Medicine, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Sion, Mumbai 22, India
    J Assoc Physicians India 52:953-8. 2004
    ..47% (11/76) and autoimmune diseases 3.94% (3/76). These were characterized by a subcortical dementia. Four month follow up of MMSE in this group showed significant and sustained improvement in the metabolic nutritional group...
  17. ncbi CADASIL syndrome in a large Turkish kindred caused by the R90C mutation in the Notch3 receptor
    U Utku
    Department of Neurology, Trakya University, Edirne, Turkey
    Eur J Neurol 9:23-8. 2002
    ..Therefore, the used molecular screening method for Notch3 mutations provides a rapid and accurate diagnostic tool in addition to the standard diagnostic procedures...
  18. ncbi Predictive accuracy of MCI subtypes for Alzheimer's disease and vascular dementia in subjects with mild cognitive impairment: a 2-year follow-up study
    S M C Rasquin
    Research Institute Brain and Behavior, Department of Psychiatry and Neuropsychology, University of Maastricht, University Hospital Maastricht, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 19:113-9. 2005
    ....
  19. ncbi Subcortical angiopathic encephalopathy in a German kindred suggests an autosomal dominant disorder distinct from CADASIL
    C Hagel
    Institute of Neuropathology, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Acta Neuropathol 108:231-40. 2004
    ..Electron microscopy revealed fragmentation and thickening of the basal lamina but electron-dense granules characteristic for CADASIL were not detected...
  20. ncbi A novel mitochondrial DNA mutation and a mutation in the Notch3 gene in a patient with myopathy and CADASIL
    S Finnila
    Department of Neurology, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    J Mol Med (Berl) 79:641-7. 2001
    ..Furthermore, its absence in nine patients from five families with R133C suggests that its relationship with the Notch3 mutation is coincidental...
  21. ncbi Schizophrenia in a patient with cerebral autosomally dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL disease)
    P A Lågas
    Psychiatric Unit, Vasa Central Hospital, FI 65320 Vasa, Finland
    Nord J Psychiatry 55:41-2. 2001
    ..In this report we present the first patient in the world literature with CADASIL and schizophrenia and discuss the co-occurrence of these conditions in the light of the literature...
  22. ncbi A novel mutation in the Notch3 gene in an Italian family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: genetic and magnetic resonance spectroscopic findings
    R L Oliveri
    Institute of Neurology, University Magna Graecia, 88100 Catanzaro, Italy
    Arch Neurol 58:1418-22. 2001
    ..Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary syndrome caused by mutations of the Notch3 gene, usually localized to exons 3 and 4...
  23. ncbi [A case of early stage CADASIL showing only dizziness and vertigo with a novel mutation of Notch 3 gene]
    Hideyuki Matsumoto
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo
    Rinsho Shinkeigaku 45:27-31. 2005
    ..This report supports the idea that the external capsule lesion is one of the signs suggestive of CADASIL as a diagnosis...
  24. ncbi Diffusion tensor imaging study of subcortical gray matter in cadasil
    N Molko
    , INSERM U334, Paris, France
    Stroke 32:2049-54. 2001
    ..The importance of this degenerative phenomenon in the pathophysiology of CADASIL requires further investigation...
  25. ncbi CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy): an Australian perspective
    T L Chuah
    Department of Neurology, Royal Brisbane Hospital, Herston, QLD 4029, Australia
    J Clin Neurosci 8:404-6. 2001
    ..Five patients (including the siblings) had mutations. Because of strong clustering of Notch3 mutations in CADASIL, this has potential as a reliable test for the disease in Australian patients...
  26. ncbi Phenotype of a homozygous CADASIL patient in comparison to 9 age-matched heterozygous patients with the same R133C Notch3 mutation
    S Tuominen
    Department of Neurology, Turku University Hospital and University of Turku, Finland
    Stroke 32:1767-74. 2001
    ..Thus, CADASIL may follow the classic definition of a dominant disease, according to which the heterozygous and homozygous patients are clinically indistinguishable...
  27. ncbi [Report of a patient with CADASIL having a novel missense mutation of the Notch 3 gene--association with alopecia and lumbar herniated disk]
    H Yamada
    Division of Neurology, Department of Internal Medicine, Kawasaki Medical School
    Rinsho Shinkeigaku 41:144-6. 2001
    ..The DNA analysis of the Notch 3 gene identified a novel missense mutation Cys174Phe in this patient. Our case report indicated the importance of the DNA analysis for the diagnosis of CADASIL...
  28. ncbi CADASIL: a monogenic condition causing stroke and subcortical vascular dementia
    Martin Dichgans
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Cerebrovasc Dis 13:37-41. 2002
    ..CADASIL has opened a new perspective in studying basic mechanisms of vessel wall degeneration and ischemic tissue damage related to small vessel disease...
  29. ncbi Insidious cognitive decline in CADASIL
    Kaarina Amberla
    Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden
    Stroke 35:1598-602. 2004
    ..The aim of this study was to characterize cognitive function in subjects with a C475T (R133C) mutation in the Notch3 gene, leading to CADASIL...
  30. ncbi Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL
    Nilima Prakash
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77, Stockholm, Sweden
    Exp Cell Res 278:31-44. 2002
    ..These data show that Notch 3 expression is conserved between mouse and human and suggest that the mouse is a valid system for analysis of CADASIL...
  31. ncbi CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia
    Hannu Kalimo
    Department of Pathology, Turku University Hospital, Finland
    Brain Pathol 12:371-84. 2002
    ..It is as yet unclear which disturbance in the Notch signaling pathway leads to the characteristic vascular pathology of CADASIL...
  32. ncbi Evaluation of diagnostic NOTCH3 immunostaining in CADASIL
    Saskia A J Lesnik Oberstein
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Acta Neuropathol 106:107-11. 2003
    ..Confirmation by DNA analysis is requisite for positive results, and when there exists high clinical suspicion, also for negative results...
  33. ncbi The role of neuroimaging in the diagnosis of vascular dementia
    G W Small
    Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024, USA
    Acta Neurol Scand Suppl 178:10-4. 2002
    ..Neuroimaging also provides information about location and size of vascular lesions that can lead to a better understanding of symptoms and may help guide therapy...
  34. ncbi Defining dementia: clinical criteria for the diagnosis of vascular dementia
    G C Roman
    Medicine Neurology, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Acta Neurol Scand Suppl 178:6-9. 2002
    ....
  35. ncbi Cholinergic denervation in a pure multi-infarct state: observations on CADASIL
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and the Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Neurology 60:1183-5. 2003
    ....
  36. ncbi [Age- and education-specific reference values for the cognitive test of the SIDAM (Structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other etiology according to ICD-10 and DSM-IV)]
    A Busse
    Klinik und Poliklinik fur Psychiatrie, Universitat Leipzig, Johannisallee 20, 04317 Leipzig, Germany
    Z Gerontol Geriatr 35:565-74. 2002
    ..This report presents age- and education-specific norms for the cognitive assessment of the SIDAM, obtained in a population-based sample of elderly people aged 75 and over (n=1001)...
  37. ncbi Interobserver variation in diagnosis of dementia by brain perfusion SPECT
    Norinari Honda
    Department of Radiology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan
    Radiat Med 20:281-9. 2002
    ..MID, respectively). Considerable interobserver variation was present in BP-SPECT interpretation. BP-SPECT may be more effective for the evaluation of dementia than MRI when the same nuclear medicine physicians interpret both images...
  38. pmc A novel mutation (C67Y)in the NOTCH3 gene in a Korean CADASIL patient
    So Young Moon
    Department of Neurology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea
    J Korean Med Sci 18:141-4. 2003
    ....
  39. ncbi Monitoring disease progression in CADASIL with diffusion magnetic resonance imaging: a study with whole brain histogram analysis
    Nicolas Molko
    INSERM U562, Orsay, Department of Neurology, CHU Lariboisière, Paris, France
    Stroke 33:2902-8. 2002
    ..The aim of the present study was to assess the sensitivity of diffusion tensor imaging for monitoring the progression of cerebral tissue damage during the course of CADASIL...
  40. pmc Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Marie Magdeleine Ruchoux
    Laboratoire de Neuropathologie, Centre Hospitalier Regional Universitaire CHRU, Lille, France
    Am J Pathol 162:329-42. 2003
    ....
  41. pmc Coexistence of CADASIL and Alzheimer's disease
    V Thijs
    Department of Neurology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    J Neurol Neurosurg Psychiatry 74:790-2. 2003
    ..Mutations in the APP, PSEN1, and PSEN2 genes were not identified. Neuropathological findings of Alzheimer's disease may be found in CADASIL patients...
  42. ncbi Cerebral hemodynamics and white matter hyperintensities in CADASIL
    Rivka van den Boom
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Cereb Blood Flow Metab 23:599-604. 2003
    ..This study suggests that a decrease in baseline TCBF in NOTCH3 mutation carriers precedes the development of white matter hyperintensities...
  43. ncbi Diverse requirements for Notch signalling in mammals
    Duncan B Sparrow
    Developmental Biology Unit, Victor Chang Cardiac Research Institute, Sydney, Australia
    Int J Dev Biol 46:365-74. 2002
    ..Finally, since not all cases of SCD are due to mutation of DLL3, we are investigating various genes to find other candidates involved in this genetic disease...
  44. ncbi Early visual function impairment in CADASIL
    V Parisi
    Clinica Oculistica Università Tor Vergata, Rome, Italy
    Neurology 60:2008-10. 2003
    ..An early vascular retinal impairment in CADASIL may precede the onset of clinical manifestations...
  45. ncbi Correlations between clinical findings and magnetization transfer imaging metrics of tissue damage in individuals with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    G Iannucci
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy
    Stroke 32:643-8. 2001
    ..Brain tissue outside PD abnormalities is also damaged. This study suggests that the extent and the severity of the brain tissue damage are critical factors in determining clinical status in CADASIL...
  46. ncbi Diagnostic strategies in CADASIL
    H S Markus
    Department of Clinical Neuroscience, St George s Hospital Medical School, London, UK
    Neurology 59:1134-8. 2002
    ..It has been suggested that the presence of granular osmiophilic material (GOM) on skin biopsy and involvement of the anterior temporal lobe and external capsule on MRI may help in diagnosis...
  47. ncbi Pathological examination in vascular dementia
    Leonardo Pantoni
    Am J Psychiatry 159:1439-40; author reply 1440-1. 2002
  48. ncbi Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation
    Stuart A Lipton
    The Burnham Institute for Medical Research, The Salk Institute for Biological Studies, The Scripps Research Institute, and the University of California San Diego, La Jolla, California 92037, USA
    Curr Drug Targets 8:621-32. 2007
    ..These second-generation drugs take advantage of the fact that the NMDA receptor has other modulatory sites in addition to its ion channel that potentially could also be used for safe but effective clinical intervention...
  49. pmc A population study of apoE genotype at the age of 85: relation to dementia, cerebrovascular disease, and mortality
    I Skoog
    Department of Psychiatry, Sahlgrenska Hospital Institute of Clinical Neurosciences, Goteborg University, Sweden
    J Neurol Neurosurg Psychiatry 64:37-43. 1998
    ..To study the association of apoE genotypes with dementia and cerebrovascular disorders in a population based sample of 85 year old people...
  50. ncbi Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders
    Stuart A Lipton
    The Scripps Research Institute, and the University of California, San Diego, La Jolla, CA 92037, USA
    J Alzheimers Dis 6:S61-74. 2004
    ..These second-generation drugs take advantage of the fact that the NMDA receptor has other modulatory sites in addition to its ion channel that potentially could also be used for safe but effective clinical intervention...
  51. ncbi Amyloid precursor protein gene isoforms in Alzheimer's disease and other neurodegenerative disorders
    P K Panegyres
    Department of Neuropathology, Royal Perth Hospital, Perth, Australia
    J Neurol Sci 173:81-92. 2000
    ..11 controls (P=0.34). Our data has not revealed differential expression of APP mRNA isoforms in AD and supports the hypothesis that post-translational events in APP metabolism are important in amyloidogenesis and the pathogenesis of AD...
  52. ncbi Efficacy and safety of nimodipine in subcortical vascular dementia: a subgroup analysis of the Scandinavian Multi-Infarct Dementia Trial
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    J Neurol Sci 175:124-34. 2000
    ....
  53. ncbi Dementia in patients undergoing long-term dialysis: aetiology, differential diagnoses, epidemiology and management
    P M Rob
    Nephrologisches Zentrum am Klinikum Süd, Kalhlhorststrasse 31, D 23552 Lübeck, Germany
    CNS Drugs 15:691-9. 2001
    ....
  54. ncbi Noninvasive biomarkers in normal pressure hydrocephalus: evidence for the role of neuroimaging
    Andrew Tarnaris
    Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom
    J Neurosurg 110:837-51. 2009
    ..The object of this literature review was to examine the role of structural and functional imaging in providing biomarkers of favorable surgical outcome...
  55. ncbi Cognitive and neurologic deficits in the MRL/lpr mouse: a clinicopathologic study
    D C Hess
    Department of Neurology, VA Medical Center, Augusta, GA 30910
    J Rheumatol 20:610-7. 1993
    ..The MRL/lpr mouse develops high titer anticardioplin antibodies (aCL) suggesting that it may be used as a model for the neurological complications of aPL...
  56. ncbi Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF
    John R Atack
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, United Kingdom
    Neurobiol Aging 23:389-96. 2002
    ..Furthermore, there were significant correlations between CSF IMPase activity and acetylcholinesterase and butyrylcholinesterase activities and total protein, suggesting co-regulation of these parameters within the CSF...
  57. ncbi White matter damage is associated with matrix metalloproteinases in vascular dementia
    G A Rosenberg
    Department of Neurology, University of New Mexico, Albuquerque 87131, USA
    Stroke 32:1162-8. 2001
    ..Because matrix metalloproteinases (MMPs) are important in cerebral infarction, we hypothesized that disturbances in the MMPs may be involved in VAD:..
  58. ncbi Antagonic-stress. A new treatment in gerontopsychiatry and for a healthy productive life
    V Predescu
    First Department of Psychiatry, Gh Marinescu Clinical Hospital, Bucharest, Romania
    Ann N Y Acad Sci 717:315-31. 1994
    ..monotherapy in geriatrics...
  59. pmc The ability of denbufylline to inhibit cyclic nucleotide phosphodiesterase and its affinity for adenosine receptors and the adenosine re-uptake site
    C D Nicholson
    Beecham Wülfing Res Labs, Gronau, F R G
    Br J Pharmacol 97:889-97. 1989
    ..5. Denbufylline is being developed as an agent for the therapy of multi-infarct dementia. The selective inhibition of a particular low Km cyclic AMP phosphodiesterase may account for the activity of this compound...
  60. ncbi Risk of dementia and alcohol and wine consumption: a review of recent results
    Luc Letenneur
    INSERM U593, Case 11, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux Cedex, France
    Biol Res 37:189-93. 2004
    ..Several studies have been published and the overall conclusion is that heavy drinking is a risk factor for most stroke subtypes. Regular light to moderate drinking seemed to be associated with a decreased risk for ischaemic stroke...
  61. ncbi [Vascular dementia]
    R Schmidt
    Neurologische Universitatsklinik, Auenbruggerplatz 22, A 8036 Graz
    Wien Med Wochenschr 152:85-91. 2002
    ..Lately, this concept is tested by several studies on the efficacy of acetylcholinesterase inhibitors in vascular dementia...
  62. ncbi Therapeutic efficacy of vincamine in dementia
    P K Fischhof
    Department of Psychiatry, Karl Franzens University of Graz, Austria
    Neuropsychobiology 34:29-35. 1996
    ..Based on the results of this trial, it can be accepted that the therapeutic effect of vincamine is superior to placebo in patients with mild to moderate dementia of degenerative and vascular etiologies...
  63. ncbi Low baseline Bispectral Index of the electroencephalogram in patients with dementia
    Maurizio Renna
    Department of Anaesthesia, Ealing Hospital, London, United Kingdom
    Anesth Analg 96:1380-5, table of contents. 2003
    ..0001). A significant proportion of patients with dementia shows a low baseline BIS. The utility of the BIS monitor in detecting dementia warrants further investigation...
  64. ncbi [Vascular dementias]
    Janine Diehl
    Klinik fur Psychiatrie und Psychotherapie, Technische Universitat Munchen, Germany
    Fortschr Neurol Psychiatr 70:145-54. 2002
    ....
  65. ncbi Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins
    M Miyamoto
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Exp Neurol 108:38-45. 1990
    ....
  66. ncbi Urinary tract infection in very old women is associated with delirium
    Irene Eriksson
    Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umea University, Umea, Sweden
    Int Psychogeriatr 23:496-502. 2011
    ..The aim of the study was to investigate whether urinary tract infection (UTI) in a representative sample of 85-, 90- and ≥95-year-old women is associated with delirium...
  67. ncbi Planum temporale analysis via a new volumetric method in autoptic brains of demented and psychotic patients
    Petr Zach
    Department of Preclinical Studies, Faculty of Health and Social Studies, South Bohemian University, Czech Republic
    Curr Alzheimer Res 6:69-76. 2009
    ..In contrast, marked but only bilateral area shrinkage as well as reduced cortical thickness and brain volumes were observed in schizophrenic patients...
  68. ncbi Serum protein leakage in Alzheimer's disease revisited
    D G Munoz
    Department of Pathology, University of Western Ontario, London, Canada
    Ann N Y Acad Sci 826:173-89. 1997
    ..Finally, no specific pattern of abnormality in the BBB was detected in multi-infarct dementia...
  69. ncbi Vascular dementia today
    G C Roman
    Dept Medicine Neurology, UT Health Science Center, San Antonio 78284 7883, USA
    Rev Neurol (Paris) 155:S64-72. 1999
    ..These findings offer hope for prevention of this growing public health problem...
  70. ncbi Effects of acupuncture on glycometabolic enzymes in multi-infarct dementia rats
    Lan Zhao
    Molecular Biology Laboratory, Acupuncture and Moxibustion Research Institute, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 300193 Tianjin, China
    Neurochem Res 36:693-700. 2011
    ....
  71. ncbi The use of olfactory receptor neurons (ORNs) from biopsies to study changes in aging and neurodegenerative diseases
    N E Rawson
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Ann N Y Acad Sci 855:701-7. 1998
    ..These studies demonstrate the feasibility of this approach to examine age or disease-associated changes in neuronal function. Further, age-related changes in ORN selectivity may contribute to changes in olfactory performance...
  72. ncbi Emission tomography in dementia
    Sanjeet Pakrasi
    Institute for Health and Ageing, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Nucl Med Commun 26:189-96. 2005
    ....
  73. ncbi [Respiratory sleep disorders in the elderly]
    J P Janssens
    Departement de Geriatrie, Hopitaux Universitaires de Geneve
    Rev Med Suisse Romande 120:869-79. 2000
    ..SRBD should be considered as a possible cause of "reversible dementia" and sought for in the presence of daytime somnolence, delirium, or unexplained right-sided heart failure in older patients...
  74. ncbi Sleep apnea in multiinfarct dementia and Alzheimer's disease
    T Erkinjuntti
    Department of Neurology, University of Helsinki, Finland
    Sleep 10:419-25. 1987
    ..Age had no effect on the proportion of apneas and hypopneas among demented patients or control subjects, but male controls had more apneas and hypopneas than did female controls...
  75. ncbi Evaluation of insomnia and daytime napping in Iranian Alzheimer disease patients: relationship with severity of dementia and comparison with normal adults
    Sina Ohadinia
    Am J Geriatr Psychiatry 12:517-22. 2004
    ..One of these problems is insomnia, which can very significantly affect patients' family members because of disturbing insomnia-related behaviors...
  76. ncbi The complex nosological concept of vascular dementia
    Amos D Korczyn
    Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    J Neurol Sci 203:3-6. 2002
    ..These unexpected findings highlight the importance of mixed vascular-degenerative dementia as a disorder which has to be properly defined and has important implications on prevention and treatment...
  77. ncbi The validity of psychometric instruments for detection of dementia in the elderly general population
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Int J Geriatr Psychiatry 13:368-80. 1998
    ..To compare the validity of different instruments for screening and diagnosis of dementia and to provide threshold scores for these purposes, ie screening focusing on a high sensitivity and diagnosis focusing on a high specificity...
  78. ncbi EEG mapping and low-resolution brain electromagnetic tomography (LORETA) in diagnosis and therapy of psychiatric disorders: evidence for a key-lock principle
    Bernd Saletu
    Department of Psychiatry, Medical University of Vienna, Austria
    Clin EEG Neurosci 36:108-15. 2005
    ..This is supported by 3-dimensional low-resolution brain electromagnetic tomography (LORETA), which identifies regions within the brain that are affected by psychiatric disorders and psychopharmacological substances...
  79. ncbi [Clinico-pathological correlation in the main types of dementia]
    B Estupiñán
    Centro Internacional de Restauracion Neurologica, Hospital Hermanos Ameijeiras, Ciudad de La Habana, Cuba
    Rev Neurol 25:547-9. 1997
    ..Pathological confirmation of the cases clinically diagnosed as Alzheimer disease/senile dementia Alzheimer type (AD/SDAT) and multi-infarct dementia (MID) was carried out...
  80. ncbi [Reliability study of the Brazilian version of a structured interview for the diagnosis of dementia]
    M Ventura
    Serviço de Geriatria, Hospital do Servidor Público Estadual Francisco Morato de Oliveira, Sao Paulo, SP
    Rev Assoc Med Bras 47:110-6. 2001
    ....
  81. ncbi Vascular cognitive disorder. A biological and clinical overview
    Leontino Battistin
    Department of Neurosciences, University of Padova Medical School, Via Giustiniani 5, 35128 Padova, Italy
    Neurochem Res 35:1933-8. 2010
    ....
  82. ncbi Severe atrophy of amygdala and hippocampus in both Alzheimer's disease and multi-infarct dementia
    T Matsuzawa
    Department of Radiology and Nuclear Medicine, Tohoku University, Sendai, Japan
    Sci Rep Res Inst Tohoku Univ Med 37:23-5. 1990
    ..There was no essential difference on the atrophic findings between Alzheimer's disease and multi-infarct dementia. This result therefore suggest that the quantitative measurement of amygdaloid and hippocampal atrophy predicts dementia...
  83. ncbi [Clinical findings in Alzheimer dementia and multi-infarct dementia]
    K L Wendland
    Abteilung Psychiatrie im Zentrum Nervenheilkunde, Universitat Kiel
    Z Gerontol 24:27-32. 1991
    ..Psychic unbalance and states of temporary mental confusion, however, were more frequent in the MID-patients...
  84. ncbi Vascular cognitive impairment: current concepts and clinical developments
    Paige Moorhouse
    Division of Geriatric Medicine, Halifax, Nova Scotia, Canada
    Lancet Neurol 7:246-55. 2008
    ..VCI might be preventable, although the evidence for this is not as complete as it is for the prevention of stroke. Future studies into specific therapies for VCI will need to consider the clinical features and outcomes carefully...
  85. ncbi Measuring the decline of a population of people with early-onset dementia in Lothian, Scotland
    K Woodburn
    Royal Edinburgh Hospital, UK
    Int J Geriatr Psychiatry 14:355-61. 1999
    ..CONCLUSIONS: There are limitations in the instruments used to measure change in this group of patients; at present, measures of change in dementing illnesses cater predominantly for an elderly population with Alzheimer's disease...
  86. ncbi [Update on vascular dementias]
    S Auriacombe
    centre mémoire de ressource et de recherche, Hopital Pellegrin, bâtiment USN Tastet Girard, 33076 Bordeaux Cedex, France
    Rev Neurol (Paris) 164:22-41. 2008
    ....
  87. ncbi Screening of patients admitted to a geriatric hospital with supposed organic dementia
    K Hedner
    Department of Community Health Sciences, Lund University, Sweden
    Compr Gerontol A 1:55-60. 1987
    ..After a follow-up period of 6 months, 33% of the patients had died. An autopsy was performed in 80% of these cases, and the clinical diagnosis was confirmed in all but four cases...
  88. ncbi The role of selective attention in the visuo-spatial memory of patients suffering from dementia of the Alzheimer type
    I A Stuart Hamilton
    Age and Cognitive Performance Research Centre, University of Manchester, England
    Compr Gerontol B 2:129-34. 1988
    ..Similarly, DAT subjects' performance on a visual search task was worsened when the displays were made more varied. The concept that DAT patients' visuo-spatial memory problems may be due to a failure of selective attention is discussed...
  89. ncbi Mixed dementia--the most common cause of dementia
    Amos D Korczyn
    Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    Ann N Y Acad Sci 977:129-34. 2002
    ..This surprising finding highlights the importance of mixed vascular-degenerative dementia as a disorder that has to be properly defined and has important implications on prevention and treatment...
  90. ncbi Do memory complaints indicate the presence of cognitive impairment? Results of a field study
    S G Riedel-Heller
    Department of Psychiatry, University of Leipzig, Johannisallee 20, D 04317 Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 249:197-204. 1999
    ..This investigation documents the prevalence of memory complaints and assesses the validity of memory complaints for detecting cognitive impairment...
  91. ncbi Detection of subthreshold depression and subthreshold anxiety in the elderly
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Int J Geriatr Psychiatry 14:643-50. 1999
    ..To assess the ability of screening instruments to detect subthreshold depression or subthreshold anxiety and to make suggestions for the improvement of instrument performance...
  92. ncbi Vascular cognitive impairment
    John T O'Brien
    Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 2:89-98. 2003
    ..Clinical trials in vascular cognitive impairment are in their infancy but support the value of therapeutic interventions for symptomatic treatment...
  93. ncbi Recruitment procedures and their impact on the prevalence of dementia. Results from the Leipzig Longitudinal Study of the Aged (LEILA75+)
    S G Riedel-Heller
    Department of Psychiatry, University of Leipzig, Germany
    Neuroepidemiology 19:130-40. 2000
    ..3 and 10.5%, respectively. It will be argued that covering the whole population in question and ensuring high response rates are central issues to minimize selection bias...
  94. ncbi Modern concept of vascular cognitive impairment
    J V Bowler
    Department of Clinical Neurosciences, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill St, London NW3 2PF, UK
    Br Med Bull 83:291-305. 2007
    ..Vascular cognitive impairment (VCI) has superseded vascular dementia and multi-infarct dementia as the concept to be used in cognitive decline due to cerebrovascular disease...
  95. ncbi [Dementia and suicide]
    B Schneider
    Zentrum der Psychiatrie, Klinik für Psychiatrie und Psychotherapie I, Johann Wolfgang Goethe Universitat, Frankfurt Main
    Fortschr Neurol Psychiatr 69:164-9. 2001
    ..This review comprehensively presents the association between cognitive deficits, insight in early stages of dementia and suicidality and possible confounders which have not systematically been investigated up to now...
  96. ncbi Is the estrogen controversy over? Deconstructing the Women's Health Initiative study: a critical evaluation of the evidence
    S Mitchell Harman
    Kronos Longevity Research Institute, 2222 E Highland, Ste 220, Phoenix, AZ 85016, USA
    Ann N Y Acad Sci 1052:43-56. 2005
    ..It will examine surrogate end points as well as risk factors for atherosclerosis...
  97. ncbi Cognitive impairment after stroke
    Hans Peter Haring
    Department of Neurology, Oberösterreichische Landesnervenklinik Wagner Jauregg, Linz, Austria
    Curr Opin Neurol 15:79-84. 2002
    ..The particular criteria chosen by a clinician or investigator to diagnose vascular dementia have a major impact on epidemiology, disease management and health economic estimates...
  98. ncbi Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people
    Petra Hovorkova
    Alzheimer Disease Center, Prague Psychiatric Center, Prague, Czech Republic
    Dement Geriatr Cogn Disord 26:193-8. 2008
    ..The multifunctional mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 could play a role in the development of Alzheimer disease via its high-affinity binding to amyloid-beta peptides and its overexpression...
  99. ncbi [Usefulness of some neurophysiological methods in different type of dementia]
    Krystyna Szyrocka-Szwed
    Z Oddziału Neurologii Szpitala Miejskiego nr 2 w Swietochłowicach
    Wiad Lek 58:549-52. 2005
    ..It was tried to estimate above mentioned neurophysiological methods from the point of view of their avalibility, simplicity of examination, repetition and usefulness in distinguishing states of dementia...
  100. ncbi Vascular cognitive deterioration and stroke
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Cerebrovasc Dis 24:189-94. 2007
    ..Whilst CVD is preventable and treatable, it is clearly a major factor in the prevalence of cognitive impairment in the elderly worldwide...
  101. ncbi Behavioral alterations and vascular dementia
    Rita Moretti
    Dipartimento di Fisiologia e Patologia, Ambulatorio Disturbi Cognitivi, Universita degli Studi di Trieste, Trieste, Italy
    Neurologist 12:43-7. 2006
    ..Negative signs, such as apathy, abulia, opposition, and agnosia, are badly tolerated and dramatically experienced by caregivers, even worse than the other signs of cognitive decline...

Research Grants26

  1. MENTAL ILLNESS IN THE ELDERLY--DIAGNOSTIC TESTING
    Andrew Leuchter; Fiscal Year: 1999
    ..Serial study will determine characteristics of lesions that adversely affect long-term prognosis, as well as the usefulness of QEEG for monitoring the evolution of white-matter disease. ..
  2. PET AND MRI IMAGING OF PERSISTENT LYME ENCEPHALOPATHY
    Brian Fallon; Fiscal Year: 2003
    ..This study will enhance our understanding of the pathophysiology and treatment of patients suffering with the disabling effects of persistent Lyme encephalopathy. ..
  3. ERPS AND VERBAL MEMORY IN AGING DEMENTIA AND AMNESIA
    John Olichney; Fiscal Year: 1999
    ..Comparisons of N400 and LPC characteristics will be made between and within subject groups and related to explicit memory abilities and other neuropsychological data. ..
  4. CONNECTIONIST MODELING IN THE NEUROLOGY OF AGING
    WILLIAM LYTTON; Fiscal Year: 1991
    ..The design is expected to use diffuse associative connectivity with specific synaptic connectivity added. These models will be manipulated to simulate particular diseases...
  5. ALTERED CALCIUM HOMEOSTASIS TO DIAGNOSE ALZHEIMER'S
    Christine Peterson; Fiscal Year: 1992
    ..These approaches will help us to diagnose Alzheimer's disease, understand the mechanisms that underlie the degenerative disorder and aid in the design of effective therapeutic strategies...
  6. MANAGEMENT OF RESISTANCE TO BATHING ACTIVITIES
    Carol Mitchell; Fiscal Year: 1992
    ..Is there a differential impact of type of dementia, (Alzheimer's Disease (AD) or Multi Infarct Dementia (MID)), and stage of dementia on resistance? 5...
  7. ALZHEIMERS DISEASE CENTER
    Paul Coleman; Fiscal Year: 2000
    ..These counts will be in addition to counts obtained for the Khachaturian diagnostic criteria. ..
  8. AIDS-Related Neurotoxicity and Novel NMDAR Antagonists
    Stuart Lipton; Fiscal Year: 2009
    ..It is anticipated that these preclinical studies investigating the role of the NMDAR in neuronal cell injury may lead to new treatments for the neurological manifestations of AIDS. ..
  9. Caspase Cleavage of MEF2 Mediates Neuronal Apoptosis
    Stuart Lipton; Fiscal Year: 2007
    ....
  10. ERYTHROPOIETIN-INDUCED NEUROPROTECTION
    Stuart Lipton; Fiscal Year: 2005
    ....
  11. Erythropoietin PLUS IGF-IN NEUROPROTECTION FROM AIDS
    Stuart Lipton; Fiscal Year: 2009
    ..Hypothesis Tested: EPO+IGF-I act synergistically to activate the anti-apoptotic PI3 kinase/Akt signaling pathway, and thus provide a synergistic degree of neuroprotection. ..
  12. Chemokines and Macrophages in HIV Neuronal Apoptosis
    Stuart Lipton; Fiscal Year: 2003
    ..Neuronal apoptosis due to gp120 or chemokines will be monitored using several approaches. ..
  13. RETINAL GANGLION CELLS: ION CHANNELS & TRANSMITTERS
    Stuart A Lipton; Fiscal Year: 2010
    ..To characterize the ligand-binding site of NR3-containing receptors, and use information from [2] and [3] to distinguish expression of NR1/NR3 "doublet" receptors from NR1/NR2/NR3 "triplet" receptors on RGCs. ..
  14. S-Nitrosylation of Matrix Metalloproteinases in AIDS
    Stuart Lipton; Fiscal Year: 2007
    ..In the future, the work proposed here may lead to new therapeutic targets based on the novel extracellular signaling pathway involving NO-related molecules and the MMPs that will be studied. ..
  15. Siblings With Ischemic Stroke Study (SWISS)
    JAMES MESCHIA; Fiscal Year: 2009
    ..DNA banking and the creation of permanent lymphoblastoid cell lines will be done to permit future collaborative efforts to study the genetic basis for stroke risk. ..
  16. Neurology of Attention and Neglect-A Network Approach
    Marek Marsel Mesulam; Fiscal Year: 2008
    ..The results of these experiments will help to understand the neurological bases of spatial attention and may lead to more rational treatments of hemispatial neglect. ..
  17. GENETIC STUDIES OF ANEURYSMAL SUBARACHNOID HEMORRHAGE
    Mark Alberts; Fiscal Year: 2003
    ..This research project combined with the PI's background and expertise provide a wide range of patient-oriented mentorship opportunities in clinical and genetic research...
  18. MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORS
    Raj Kalaria; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. MODELS OF PARTNER AND PARENT AGGRESSION
    K O Leary; Fiscal Year: 2003
    ....
  20. ISGS: The Ischemic Stroke Genetics Study
    JAMES MESCHIA; Fiscal Year: 2006
    ..The application and SWISS share the same definitions for the present and absence of phenotype and key enrollment criteria. ..
  21. MENTAL DISORDERS OF AGING--ANTIINFLAMMATION IN AD
    Gary Small; Fiscal Year: 2003
    ....
  22. Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
    Christopher H van Dyck; Fiscal Year: 2010
    ..This Pilot Clinical Trial will provide essential preliminary data for a subsequent full-scale trial of guanfacine for prefrontally-mediated cognitive dysfunction in elderly subjects. ..
  23. Copper Complexing with Tetrathiomolybdate in a Murine Model of Alzheimers Disease
    Joseph Quinn; Fiscal Year: 2007
    ..These are the critical pieces of information for determining if TM should be evaluated in clinical trials for either the prevention or the treatment of Alzheimer's disease. [unreadable] [unreadable] [unreadable]..