vascular dementia

Summary

Summary: An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)

Top Publications

  1. doi Is it possible to treat vascular dementia?
    Dina Zekry
    Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Thonex, Geneva, Switzerland
    Front Neurol Neurosci 24:95-106. 2009
  2. pmc Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 61:358-64. 2003
  3. ncbi Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia
    Guizhi Zhang
    Department of Physiology, Medical College of Qingdao University, 308 Ningxia Road, Qingdao 266071, PR China
    J Ethnopharmacol 115:441-8. 2008
  4. ncbi Subcortical ischaemic vascular dementia
    Gustavo C Roman
    University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
    Lancet Neurol 1:426-36. 2002
  5. pmc The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
    Arch Neurol 66:300-5. 2009
  6. ncbi Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?
    T von Zglinicki
    Institute of Pathology at the Evangelische Geriatriezentrum Berlin, Germany
    Lab Invest 80:1739-47. 2000
  7. ncbi The gene encoding transforming growth factor beta 1 confers risk of ischemic stroke and vascular dementia
    Younyoung Kim
    Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang, Kyonggi do 431 060, South Korea
    Stroke 37:2843-5. 2006
  8. ncbi Vascular dementia prevention: a risk factor analysis
    Gustavo C Roman
    Department of Medicine Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
    Cerebrovasc Dis 20:91-100. 2005
  9. ncbi Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
    Elisabeth Tarkowski
    Department of Rheumatology, University of Goteborg, Goteborg, Sweden
    Neurobiol Aging 23:237-43. 2002
  10. ncbi Towards defining the neuropathological substrates of vascular dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 226:75-80. 2004

Detail Information

Publications346 found, 100 shown here

  1. doi Is it possible to treat vascular dementia?
    Dina Zekry
    Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Thonex, Geneva, Switzerland
    Front Neurol Neurosci 24:95-106. 2009
    Randomized controlled trials of primary and secondary prevention of vascular dementia demonstrate real effects on the cause or progression of disease (disease-modifying treatment)...
  2. pmc Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
    N Schuff
    Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
    Neurology 61:358-64. 2003
    1) To determine the regional pattern of reduced N-acetylaspartate (NAA) in subcortical ischemic vascular dementia (SIVD); 2) to explore the relationship between NAA reduction and subcortical vascular disease; and 3) to test if MR ..
  3. ncbi Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia
    Guizhi Zhang
    Department of Physiology, Medical College of Qingdao University, 308 Ningxia Road, Qingdao 266071, PR China
    J Ethnopharmacol 115:441-8. 2008
    ..Ginsenosides, the major active ingredients of Panax ginseng, produce a variety of pharmacological or physiological responses with effects on the central and peripheral nervous systems...
  4. ncbi Subcortical ischaemic vascular dementia
    Gustavo C Roman
    University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
    Lancet Neurol 1:426-36. 2002
    b>Vascular dementia is the second most common type of dementia. The subcortical ischaemic form (SIVD) frequently causes cognitive impairment and dementia in elderly people...
  5. pmc The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
    Arch Neurol 66:300-5. 2009
    ..also proved difficult to distinguish in human patients, blurring the lines between Alzheimer disease and vascular dementia. This review highlights recent work aimed at identifying convergent mechanisms such as insulin resistance ..
  6. ncbi Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?
    T von Zglinicki
    Institute of Pathology at the Evangelische Geriatriezentrum Berlin, Germany
    Lab Invest 80:1739-47. 2000
    ..However, specific risk factors for vascular dementia are still not known. Human telomeres shorten with each cell division in vitro and with donor age in vivo...
  7. ncbi The gene encoding transforming growth factor beta 1 confers risk of ischemic stroke and vascular dementia
    Younyoung Kim
    Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang, Kyonggi do 431 060, South Korea
    Stroke 37:2843-5. 2006
    ..We investigated the association of the polymorphism in TGFB1 with ischemic stroke and vascular dementia.
  8. ncbi Vascular dementia prevention: a risk factor analysis
    Gustavo C Roman
    Department of Medicine Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
    Cerebrovasc Dis 20:91-100. 2005
    ..from ischemic or hemorrhagic cerebrovascular disease (CVD) produces decline in cognitive functions and vascular dementia (VaD). Likewise, CVD may cause VaD from hypoperfusion of susceptible brain areas...
  9. ncbi Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
    Elisabeth Tarkowski
    Department of Rheumatology, University of Goteborg, Goteborg, Sweden
    Neurobiol Aging 23:237-43. 2002
    The aim of the present study was to investigate, in patients with Alzheimer's disease (AD), and vascular dementia (VAD), patterns of local release of vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta)..
  10. ncbi Towards defining the neuropathological substrates of vascular dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 226:75-80. 2004
    Cerebrovascular disease is highly heterogeneous but can culminate in vascular cognitive impairment or vascular dementia (VaD)...
  11. doi Cortical microinfarcts in Alzheimer's disease and subcortical vascular dementia
    Yoko Okamoto
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neuroreport 20:990-6. 2009
    Cortical microinfarcts are reported in Alzheimer's disease, but not in subcortical vascular dementia; the disease specificity of cortical microinfarcts therefore remains unclear...
  12. doi The restoration after repetitive transcranial magnetic stimulation treatment on cognitive ability of vascular dementia rats and its impacts on synaptic plasticity in hippocampal CA1 area
    Fei Wang
    Department of Neurology, General Hospital, Tianjin Medical University, Tianjin, People s Republic of China
    J Mol Neurosci 41:145-55. 2010
    The purposes of this research were to study the restoration on the cognitive ability of rat models with vascular dementia (VaD) by repetitive transcranial magnetic stimulation (rTMS) treatment and its impacts on synaptic plasticity in ..
  13. pmc Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus
    A T Du
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Neurology 58:1635-41. 2002
    To determine the effects of subcortical ischemic vascular dementia (SIVD) and AD on entorhinal cortex (ERC) and hippocampus.
  14. doi Mild cognitive impairment in stroke patients with ischemic cerebral small-vessel disease: a forerunner of vascular dementia?
    Marta Grau-Olivares
    Cerebrovascular Division, Department of Neurology, Hospital Universitari del Sagrat Cor, Universitat de Barcelona, E 08029 Barcelona, Spain
    Expert Rev Neurother 9:1201-17. 2009
    ..Ischemic cerebral small-vessel disease should be regarded as a potentially severe condition prodrome of subcortical vascular dementia rather than a relatively benign disorder.
  15. doi Oxidative stress in vascular dementia and Alzheimer's disease: a common pathology
    Stuart Bennett
    School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    J Alzheimers Dis 17:245-57. 2009
    Alzheimer's disease and vascular dementia are the two most common types of dementia with the former being the most predominant...
  16. pmc Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging
    S Mackay
    Magnetic Resonance Spectroscopy Unit, Department of Veterans Affairs Medical Center, San Francisco, USA
    Arch Neurol 53:167-74. 1996
    ..creatine plus phosphocreatine [Cr]) in subjects with Alzheimer's disease (AD), with subcortical ischemic vascular dementia (SIVD), and elderly controls. DESIGN: Cross-sectional, between groups...
  17. ncbi Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimer's disease and vascular dementia
    P H Yu
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Med Hypotheses 57:175-9. 2001
    ..Formaldehyde may cause cytotoxicity, which induces inflammation and release of more SSAO, producing a cascade of toxic cycle. Increased SSAO-mediated reaction may be chronically involved in the pathogenesis of vascular dementia and AD.
  18. doi CSF biomarker profile and diagnostic value in vascular dementia
    G P Paraskevas
    Department of Neurology, School of Medicine, Athens National University, Athens, Greece
    Eur J Neurol 16:205-11. 2009
    The differential diagnosis between vascular dementia (VD) and Alzheimer's disease (AD) or mixed dementia (MD) is not always easy in clinical practice...
  19. ncbi The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia
    Kelly Davis Garrett
    Department of Psychiatry and Human Behavior, Brown Medical School, USA
    Arch Clin Neuropsychol 19:745-57. 2004
    ..individuals at risk for cerebrovascular disease (R-CVD), 18 individuals with VaCIND, and 26 individuals with vascular dementia (VaD) were examined to determine whether patterns of neuropsychological assessment performance can assist in ..
  20. ncbi MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 54:1304-9. 2000
    To compare global and regional atrophy on MRI in subjects with dementia with Lewy bodies (DLB), AD, vascular dementia (VaD), and normal aging...
  21. doi Vascular and biochemical risk factors of vascular dementia after lacunar strokes (S-VaD) and after multiinfarcts in strategic areas (M-VaD)
    Ałła Graban
    First Department of Neurology and Institute of Psychiatry and Neurology, Warsaw, Poland
    J Neurol Sci 283:116-8. 2009
    ..Ischemic lesions in the brain have an influence on the natural history of dementia. Vascular dementia can be caused by small-vessels disease (S-VaD) or by large-artery atherosclerosis with vascular lesions in ..
  22. ncbi Body mass index in midlife and risk of Alzheimer disease and vascular dementia
    Rachel A Whitmer
    Kaiser Permanente Division of Research, Etiology and Prevention, 2000 Broadway, Oakland, CA 94612, USA
    Curr Alzheimer Res 4:103-9. 2007
    ..It is unknown if there is a difference in the risk of developing Alzheimer disease (AD) versus vascular dementia (VaD) associated with high body weight...
  23. pmc Cognitive impact of subcortical vascular and Alzheimer's disease pathology
    Helena C Chui
    Department of Neurology, University of Southern California, Los Angeles, USA
    Ann Neurol 60:677-87. 2006
    ..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype...
  24. doi Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study
    A Sekita
    Department of Environmental Medicine, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka City, Japan
    Acta Psychiatr Scand 122:319-25. 2010
    To examine secular trends in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) in a general Japanese population.
  25. ncbi Risk factors for vascular dementia and Alzheimer disease
    Philip B Gorelick
    Department of Neurology and Rehabilitation, University of Illinois College of Medicine at Chicago, 912 South Wood St, Room 855N, Chicago, IL 60612, USA
    Stroke 35:2620-2. 2004
    ..We review vascular factors that might be responsible to cognitive decline in Alzheimer disease and vascular cognitive impairment and the corresponding interventions that might prevent cognitive impairment as we age...
  26. ncbi The enigma of vascular cognitive disorder and vascular dementia
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria
    Acta Neuropathol 113:349-88. 2007
    The prevalence, morphology and pathogenesis of vascular dementia (VaD), recently termed vascular cognitive impairment, are a matter of discussion, and currently used clinical diagnostic criteria show moderate sensitivity (average 50%) ..
  27. ncbi Similarities between Alzheimer's disease and vascular dementia
    Raj Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Sci 203:29-34. 2002
    Alzheimer's disease (AD) and vascular dementia (VaD) are the two most common forms of dementia. In Europe, 800,000 people have a diagnosis of VaD out of 3.7 million people with clinical dementia...
  28. ncbi Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia
    Marieke van Oijen
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Stroke 36:2637-41. 2005
    ..Both fibrinogen and C-reactive protein are considered inflammatory markers. Fibrinogen also has important hemostatic properties. We investigated the association of fibrinogen and C-reactive protein with dementia...
  29. ncbi Vascular dementia in a population-based autopsy study
    David S Knopman
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arch Neurol 60:569-75. 2003
    The validity of the clinical diagnosis of vascular dementia (VaD) remains suboptimal.
  30. ncbi Brain hypoperfusion: a critical factor in vascular dementia
    Gustavo C Roman
    University of Texas Health Science Center at San Antonio and the Audie L Murphy Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, San Antonio, USA
    Neurol Res 26:454-8. 2004
    Subcortical ischemic vascular dementia is a relatively common form of dementia. Anatomical changes of ageing in the brain arteries predispose the elderly to the effects of hypotension...
  31. ncbi Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu
    Zhen Xin Zhang
    Department of Clinical Epidemiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Arch Neurol 62:447-53. 2005
    Prevalences of Alzheimer disease (AD) and vascular dementia (VaD) in China reportedly differ from those in Western countries.
  32. ncbi Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia
    Chie Yasutake
    Department of Neuropsychiatry, Osaka Medical College, Daigakumachi 2 7, Takatsuki, Osaka, Japan
    Eur Arch Psychiatry Clin Neurosci 256:402-6. 2006
    ..The following subjects were included in this study: 60 AD patients, 60 vascular dementia (VaD) patients and 33 healthy controls...
  33. ncbi Prevalence, resource utilization and costs of vascular dementia compared to Alzheimer's dementia in a population setting
    A Sicras
    Badalona Serveis Assistencials SL, Badalona, Barcelona, Spain
    Dement Geriatr Cogn Disord 19:305-15. 2005
    To determine the prevalence of dementia and to measure the monetary impact and health resources utilization of vascular dementia (VD) compared to Alzheimer's dementia (AD) in persons aged over 64 years in a population setting.
  34. ncbi Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia
    H Lewis
    Department of Molecular and Cellular Neuroscience, Merck, Sharp and Dohme Research Laboratories, Terlings Park, Essex
    Neuropathol Appl Neurobiol 32:103-18. 2006
    Clinicopathological observations suggest there is considerable overlap between vascular dementia (VaD) and Alzheimer's disease (AD)...
  35. ncbi Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
    Dement Geriatr Cogn Disord 18:265-70. 2004
    ..regarding the simultaneous behavior of peripheral antioxidants and biomarkers of oxidative stress in AD and vascular dementia (VaD). Sixty-three AD patients, 23 VaD patients and 55 controls were included in the study...
  36. doi Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study
    S Ahtiluoto
    Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    Neurology 75:1195-202. 2010
    To investigate the relation of diabetes to dementia, Alzheimer disease (AD), and vascular dementia (VaD), through analyses of incidence, mortality, and neuropathologic outcomes in a prospective population-based study of the oldest old.
  37. pmc Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging
    Norbert Schuff
    Department of Veterans Affairs Medical Center, University of California at San Francisco, USA
    Alzheimers Dement 5:454-62. 2009
    Our objectives were to compare the effects of subcortical ischemic vascular dementia (SIVD) and Alzheimer's disease (AD) on cerebral blood flow (CBF), and then to analyze the relationship between CBF and subcortical vascular disease, ..
  38. doi Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease
    Sasha Dhoat
    Faculty of Medicine, Imperial College, London, UK
    Age Ageing 37:653-9. 2008
    to determine whether functional changes in the vasculature differ between Alzheimer's disease (AD) and vascular dementia (VAD).
  39. ncbi Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia
    H K Wang
    Department of Life Science, National Taiwan Normal University, Taipei, Taiwan
    J Neural Transm (Vienna) 113:1499-509. 2006
    Lipoproteins and vascular factors may play roles in the development of Alzheimer's disease (AD) and/or vascular dementia (VaD)...
  40. ncbi Effect of acupuncture treatment on vascular dementia
    Jianchun Yu
    Gerontological Department, The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    Neurol Res 28:97-103. 2006
    Recent studies have suggested that acupuncture can ameliorate some symptoms commonly associated with vascular dementia (VaD)...
  41. ncbi 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysis
    Nacer Kerrouche
    INSERM U320, University of Caen, Caen, France
    J Cereb Blood Flow Metab 26:1213-21. 2006
    The brain metabolic pattern of vascular dementia (VaD) remains poorly characterized. Univariate voxel-based analysis ignores the functional correlations among structures and may lack sensitivity and specificity...
  42. ncbi Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study
    Danielle Laurin
    Neuroepidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Epidemiol 159:959-67. 2004
    ..disease, 38 cases of Alzheimer's disease with contributing cerebrovascular disease, and 44 cases of vascular dementia)...
  43. ncbi Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease
    Andrea Flex
    Istituto di Medicina Interna e Geriatria, Policlinico A Gemelli, Universita Cattolica del Sacro Cuore, L go A Gemelli 8, 00168 Rome, Italy
    J Gerontol A Biol Sci Med Sci 61:1065-9. 2006
    b>Vascular dementia (VAD) and Alzheimer's disease (AD) may share common neuropathological mechanisms. Matrix metalloproteinases (MMPs) may induce destruction of the extracellular matrix, neuronal dysfunction, and death...
  44. ncbi Acupuncture increases cerebral glucose metabolism in human vascular dementia
    Yong Huang
    Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
    Int J Neurosci 117:1029-37. 2007
    Recent studies indicate beneficial effects of acupuncture in the rehabilitation of vascular dementia (VaD)...
  45. ncbi Impact of increased plasma serotonin levels and carotid atherosclerosis on vascular dementia
    Yoshiyuki Ban
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Atherosclerosis 195:153-9. 2007
    ..The present study aims at evaluating the relationship between plasma levels of 5-HT and vascular dementia (VaD) caused by stroke or atherosclerotic small vessel disease...
  46. doi Childhood cognitive ability and risk of late-onset Alzheimer and vascular dementia
    Brian McGurn
    Geriatric Medicine Unit, University of Edinburgh, UK
    Neurology 71:1051-6. 2008
    ..We investigated differential effects of premorbid cognitive ability on dementia subtypes to clarify which causal pathway was predominant...
  47. ncbi Autonomic function assessed by heart rate variability is normal in Alzheimer's disease and vascular dementia
    L M Allan
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, London, UK
    Dement Geriatr Cogn Disord 19:140-4. 2005
    ..HRV has not been studied in vascular dementia (VAD). We investigate autonomic function in AD and VAD, using power spectral analysis of HRV...
  48. pmc Subcortical vascular dementia: integrating neuropsychological and neuroradiologic data
    C C Price
    Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
    Neurology 65:376-82. 2005
    Research criteria for subcortical vascular dementia are based on radiologic evidence of vascular pathology and greater impairment on tests of executive control than memory...
  49. ncbi Status of risk factors for vascular dementia
    I Skoog
    Institute of Clinical Neuroscience, Sahlgrenska Hospital, Goteborg University, Sweden
    Neuroepidemiology 17:2-9. 1998
    The two most common causes of vascular dementia (VAD) are dementia evolving in connection with multiple small or large strokes and dementia related to ischemic white-matter lesions (WMLs) of the brain...
  50. doi Validity of the clinical diagnostic criteria for vascular dementia: a critical review. Part II
    Sandra Wiederkehr
    Ecole de Psychologie, Universite Laval, Quebec, QC, G1V OA6, Canada
    J Neuropsychiatry Clin Neurosci 20:162-77. 2008
    This review is the second of a two-part series focusing on the validity of eight clinical criteria for vascular dementia. Sixteen studies were selected according to their purposes and quality of experimental design...
  51. ncbi The role of brain infarcts and hippocampal atrophy in subcortical ischaemic vascular dementia
    G Gainotti
    Institute of Neurology, Catholic University, Policlinico Gemelli, Largo A Gemelli 8, I 00168 Rome, Italy
    Neurol Sci 25:192-7. 2004
    ..A total of 39 patients multiple subcortical infarcts, who could be considered as possible vascular dementia with small vessel pathology, with underwent a neuropsychological study and brain magnetic resonance imaging (..
  52. ncbi Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians
    D R S Souza
    Departamento de Biologia Molecular, Faculdade de Medicina de Sao Jose do Rio Preto, SP, Brasil
    Braz J Med Biol Res 36:919-23. 2003
    ....
  53. ncbi White matter damage is associated with matrix metalloproteinases in vascular dementia
    G A Rosenberg
    Department of Neurology, University of New Mexico, Albuquerque 87131, USA
    Stroke 32:1162-8. 2001
    ..multi-infarct dementia (MID) or Binswanger's disease (BD), the latter of which is a progressive form of vascular dementia (VaD) associated pathologically with fibrinoid and hyaline changes in brain arterioles with injury to the ..
  54. ncbi Differences in the behavioral and psychological symptoms between Alzheimer's disease and vascular dementia: are the different pharmacologic treatment strategies justifiable?
    Jae Min Kim
    Department of Psychiatry, College of Medicine, Chosun University, Kwangju, Republic of Korea
    Hum Psychopharmacol 18:215-20. 2003
    ..behavioral and psychological symptoms of dementia (BPSD) between patients with Alzheimer's disease (AD) and vascular dementia (VaD); (2) to investigate the differences in the correlates of BPSD between them; and (3) to suggest ..
  55. ncbi The progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer's disease
    C Ballard
    Reader in Old Age Psychiatry, University of Newcastle, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 16:499-503. 2001
    ..Little is known about the rate of progression or associations of cognitive impairment in dementia with Lewy bodies (DLB), or the associations of accelerated decline...
  56. ncbi Classification of vascular dementia in the Cardiovascular Health Study Cognition Study
    O L Lopez
    Departments of Neurology, University of Pittsburgh School of Medicine, PA, USA
    Neurology 64:1539-47. 2005
    To describe the diagnostic classification of subjects with incident vascular dementia (VaD) participating in the Cardiovascular Health Study (CHS) Cognition Study.
  57. ncbi Metabolic alterations in the hypothalamus and basal forebrain in vascular dementia
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, Amsterdam
    J Neuropathol Exp Neurol 63:1243-54. 2004
    ..the present study we aimed at determining for the first time whether metabolic changes would also occur in vascular dementia (VD) patients in the supraoptic (SON), infundibular (INF), tuberomamillary (TMN), medial mamillary nuclei, ..
  58. doi The value of quantitative EEG in differential diagnosis of Alzheimer's disease and subcortical vascular dementia
    M Gawel
    Department of Neurology, Medical University of Warsaw, Poland
    J Neurol Sci 283:127-33. 2009
    ..To investigate whether quantitative EEG may be useful in differential diagnosis of AD and SVD and to determine the correlation between dementia and abnormalities in EEG...
  59. ncbi Clinical significance of microbleeds in subcortical vascular dementia
    Sang Won Seo
    Stroke 38:1949-51. 2007
    Despite many studies investigating the association between the ischemic changes and cognitive impairment in subcortical vascular dementia (SVaD), few studies correlated cognitive impairment with microbleeds (MBs) frequently seen in SVaD.
  60. ncbi Small dense low-density lipoprotein and carotid atherosclerosis in relation to vascular dementia
    Takuya Watanabe
    Third Department of Internal Medicine, Showa University School of Medicine, Division of Internal Medicine, Showa University Karasuyama Hospital, Tokyo, Japan
    Metabolism 53:476-82. 2004
    b>Vascular dementia (VaD) and Alzheimer's disease (AD) are the most common causes of dementia in the elderly...
  61. ncbi Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease, and vascular dementia
    M P Walker
    Medical Research Council Neurochemical Pathology Unit, Institute for the Health of the Elderly, Newcastle, UK
    Neurology 54:1616-25. 2000
    ..Case reports and clinical observations suggest that fluctuating cognition (FC) is common in the major dementias, particularly dementia with Lewy bodies (DLB), where it is one of three core clinical diagnostic features...
  62. doi Lipids' peroxidation markers in Alzheimer's disease and vascular dementia
    Katarzyna Gustaw-Rothenberg
    University Memory and Cognition Center, Neurological Institute, Case Western Reserve University, Beachwood, Ohio 44122, USA
    Geriatr Gerontol Int 10:161-6. 2010
    ..In this study, the level of various oxidative stress parameters were measured in AD, vascular dementia (VaD), and age- and sex-matched control patients...
  63. ncbi Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 64:494-500. 2005
    ..This investigation examined the association between cerebrovascular disease and the pathologic manifestations of AD in an autopsy series...
  64. ncbi Vascular dementia: clinical, neuroradiologic and neuropathologic aspects
    M E Murray
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Panminerva Med 49:197-207. 2007
    b>Vascular dementia (VaD) is the second most common form of dementia after Alzheimer's disease (AD), and some studies suggest that the frequency increases exponentially over the age of 65 years...
  65. pmc Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects
    S Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium
    J Neurol Neurosurg Psychiatry 74:1148-51. 2003
    The authors conducted a prospective study of neurodegenerative and vascular dementia in Belgium. Strict diagnostic inclusion criteria were used to include well defined patients and controls...
  66. ncbi Comparative study of the specificities of needling acupoints DU20, DU26 and HT7 in intervening vascular dementia in different areas in the brain on the basis of scale assessment and cerebral functional imaging
    Yong Huang
    TCM College of Nanfang Medical University, Guangzhou, 510515, China
    Chin J Integr Med 13:103-8. 2007
    ..of clinical scale assessment and cerebral functional imaging to compare the relative specificity of needling acupoints Baihui (DU20), Shuigou (DU26) and Shenmen (HT7) in intervening vascular dementia (VD) in different areas in the brain.
  67. ncbi Progression of mild cognitive impairment to Alzheimer's or vascular dementia versus normative aging among elderly Chinese
    Juebin Huang
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Alzheimer Res 2:571-8. 2005
    ..evolutionary progressions from Mild Cognitive Impairment (MCI) to dementia of Alzheimer's type (DAT) or to vascular dementia (VaD) versus normal aging, subjects identified as MCI or as cognitively normal (CN) during standard ..
  68. doi Neuropsychiatric profiles of patients with Alzheimer's disease and vascular dementia in Taiwan
    Chia Jung Hsieh
    School of Geriatric Nursing and Care Management, College of Nursing, Taipei Medical University, Taipei, Taiwan, ROC
    Int J Geriatr Psychiatry 24:570-7. 2009
    Previous studies have reported several conflicting findings regarding neuropsychiatric symptoms when comparing patients with Alzheimer's disease (AD) and patients with vascular dementia (VaD).
  69. pmc Vascular dementia: prevention and treatment
    Catherine McVeigh
    Department of Geriatric Medicine, Faculty of Medicine and Health Sciences, Queen s University of Belfast, Belfast, Northern Ireland, UK
    Clin Interv Aging 1:229-35. 2006
    b>Vascular dementia (VaD) is the most common cause of dementia in the elderly, second only to Alzheimer's disease (AD)...
  70. doi Vascular dementia
    Michael J Schneck
    Neurology and Neurosurgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, USA
    Top Stroke Rehabil 15:22-6. 2008
    b>Vascular dementia (VaD) is the second most common form of dementia after Alzheimer's dementia (AD)...
  71. ncbi Behavioral alterations and vascular dementia
    Rita Moretti
    Dipartimento di Fisiologia e Patologia, Ambulatorio Disturbi Cognitivi, Universita degli Studi di Trieste, Trieste, Italy
    Neurologist 12:43-7. 2006
    b>Vascular dementia is one of the most frequent forms of dementia, where behavioral and cognitive symptoms coexist...
  72. ncbi Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia
    J T O'Brien
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Neurology 56:1386-8. 2001
    ..boundary shift integral on serial MRI, in patients with dementia with Lewy Bodies (DLB, n = 10), AD (n = 9), vascular dementia (VaD, n = 9), and age-matched controls (n = 20)...
  73. doi A mouse model characterizing features of vascular dementia with hippocampal atrophy
    Keiko Nishio
    Department of Neurology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507 Japan
    Stroke 41:1278-84. 2010
    ..circuit damage without apparent gray matter changes, indicating similarities with subcortical ischemic vascular dementia. However, as subcortical ischemic vascular dementia progresses over time, the longer-term effects that ..
  74. doi Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia
    G Zuliani
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, Italy
    J Neurol Sci 272:164-70. 2008
    ..60) or vascular dementia (VD: n. 80)...
  75. ncbi A review of the epidemiological transition in dementia--cross-national comparisons of the indices related to Alzheimer's disease and vascular dementia
    G H Suh
    Department of Psychiatry, Hallym University College of Medicine, Hangang Sacred Heart Hospital, Seoul, Korea
    Acta Psychiatr Scand 104:4-11. 2001
    ..RESULTS: Alzheimer's disease (AD) has become nearly twice as prevalent as vascular dementia (VaD) in Korea, Japan, and China since transition in early 1990s...
  76. ncbi Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population
    T Yamada
    Department of Internal Medicine and Health Care, Fukuoka University, School of Medicine, Japan
    Psychiatry Clin Neurosci 55:21-5. 2001
    ..8 for all types of dementia, 2.1 for Alzheimer's disease (AD), 1.0 for vascular dementia (VD) and 0.7 for other types of dementia...
  77. ncbi Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer's type
    K Mishima
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Chronobiol Int 15:647-54. 1998
    ..effect of morning bright and dim light exposure on rest-activity (R-A) rhythm disorders in patients with vascular dementia (VD) and patients with dementia of Alzheimer's type (DAT)...
  78. ncbi Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia
    Yoshiyuki Ban
    Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Tokyo 142 8555, Japan
    J Atheroscler Thromb 16:179-87. 2009
    ..The expression of UII and its receptor (UT) mRNA is detected at high levels in the brain. We evaluated the relationship between plasma UII levels and vascular dementia (VaD) caused by stroke or atherosclerotic small vessel disease.
  79. doi Cytokines in Alzheimer's disease and vascular dementia
    P Angelopoulos
    General Hospital of Xanthi, Greece
    Int J Neurosci 118:1659-72. 2008
    ..significant correlation was recorded in the interleukin levels among patients with Alzheimer's disease and vascular dementia. Also, no significant correlation was observed in the interleukin levels in the serum and the severity of ..
  80. pmc Subcortical ischemic vascular dementia
    Helena C Chui
    Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA
    Neurol Clin 25:717-40, vi. 2007
    Subcortical ischemic vascular dementia (SIVD) has been proposed as a subtype of vascular cognitive impairment. MRI often discloses "silent" hyperintensities in 20% to 40% of community-dwelling elderly...
  81. ncbi Subcortical vascular dementia
    Timo Erkinjuntti
    Memory Research Unit, Department of Clinical Neurosciences, University of Helsinki, Finland
    Cerebrovasc Dis 13:58-60. 2002
    b>Vascular dementia (VaD) incorporates different vascular mechanisms and changes in the brain, and has different causes and clinical manifestations...
  82. ncbi Plasma cytokines profile in older subjects with late onset Alzheimer's disease or vascular dementia
    G Zuliani
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, and Long Term Division, Ca Foncello Hospital, Treviso, Italy
    J Psychiatr Res 41:686-93. 2007
    ..A possible increase in plasma cytokines levels has been reported in LOAD and vascular dementia (VD), but the results of previous studies are conflicting...
  83. ncbi Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia
    D Bathgate
    Department of Neurology, Manchester Royal Infirmary, UK
    Acta Neurol Scand 103:367-78. 2001
    ..CONCLUSIONS: Behavioural characteristics accurately differentiate FTD from AD and CvD. The findings highlight the particular importance of affective change in FTD, and underline the role of the frontotemporal lobes in emotion...
  84. ncbi Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland
    Stephen P McIlroy
    Department of Geriatric Medicine, Queen s University Belfast, Belfast, Northern Ireland
    Stroke 33:2351-6. 2002
    ..Variation in the levels of this amino acid has been shown to be due to nutritional status and methylenetetrahydrofolate reductase (MTHFR) genotype...
  85. ncbi Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging Study
    Michael H Freitag
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Stroke 37:33-7. 2006
    ..This study explores whether this association is attributable to the pulsatile, ie, pulse pressure (PP), or the nonpulsatile component of blood pressure (BP)...
  86. doi Progression of mild cognitive impairment to dementia: contribution of cerebrovascular disease compared with medial temporal lobe atrophy
    Salka S Staekenborg
    Department of Neurology, Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 40:1269-74. 2009
    ....
  87. ncbi Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials
    Harish Kavirajan
    Department of General Internal Medicine, Division of Health Services Research, Veterans Affairs Greater Los Angeles Health Care System, CA, USA
    Lancet Neurol 6:782-92. 2007
    Cholinesterase inhibitors and memantine do not have regulatory approval in most of the world for treatment of vascular dementia. A systematic review and meta-analysis was undertaken to assess the evidence for efficacy and safety of ..
  88. ncbi Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementia
    R Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli, Rome, Italy
    Neurology 60:2013-4. 2003
  89. doi Elevated plasma fibrin D-dimer as a risk factor for vascular dementia: the Three-City cohort study
    L Carcaillon
    INSERM Unit 780, Cardiovascular Epidemiology, Villejuif
    J Thromb Haemost 7:1972-8. 2009
    ..However, few studies have investigated these associations in the elderly. Moreover, vascular factors may be involved in dementia. Data on the relationship between hemostatic biomarkers and dementia remain scarce...
  90. pmc Relation of plasma lipids to Alzheimer disease and vascular dementia
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Arch Neurol 61:705-14. 2004
    The relation between plasma lipid levels and Alzheimer disease (AD) and vascular dementia (VaD), and the impact of drugs to lower lipid levels remains unclear.
  91. pmc Autonomic dysfunction in dementia
    L M Allan
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 78:671-7. 2007
    There are no studies of autonomic function comparing Alzheimer's disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).
  92. ncbi Neuropsychiatric symptoms in dementia-frequency, relationship to dementia severity and comparison in Alzheimer's disease, vascular dementia and frontotemporal dementia
    S Srikanth
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 236:43-8. 2005
    ..their relationship to dementia severity and compared these disturbances in Alzheimer's disease (AD), vascular dementia (VaD) and frontotemporal dementia (FTD) using the 12-item Neuropsychiatric Inventory (NPI)...
  93. pmc Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brains
    Mihaela O Romanitan
    Laboratory of Molecular Medicine, Victor Babes National Institute of Pathology, Spl Independentei, Bucharest, Romania
    J Cell Mol Med 14:1088-100. 2010
    ..In a previous study we found in Alzheimer's disease (AD) and vascular dementia (VaD) brains an altered expression of occludin, a molecular partner of Cls in the TJs structure...
  94. doi Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type
    Sang Won Seo
    Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    J Neuroimaging 20:37-45. 2010
    ..Similarly, MCI associated with small-vessel disease (svMCI), might be a forme froste of subcortical vascular dementia (SVaD)...
  95. doi Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in rats
    Li Mei Zhang
    Guang anmen Hospital, China Academy of Chinese Medical Science, Beijing, People s Republic of China
    Neurochem Res 34:1984-92. 2009
    ..The current study was undertaken to investigate whether H(2)S attenuates the neuronal injury induced by vascular dementia (VD)...
  96. ncbi Vascular basis of Alzheimer's pathogenesis
    J C de La Torre
    Division of Neuropathology, University of California San Diego, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
    Ann N Y Acad Sci 977:196-215. 2002
    ..in motion metabolic, neurodegenerative, and cognitive changes in Alzheimer brains; (2) evidence that AD and vascular dementia (VaD) share many similar risk factors; (3) evidence that pharmacotherapy that improves cerebrovascular ..
  97. ncbi The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function
    H B Posner
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neurology 58:1175-81. 2002
    ..Hypertension at the age of 45 to 50 years may predispose to AD later in life. It is not known whether hypertension after age 65 years also contributes to AD risk, and its effect on cognitive function is also not fully understood...
  98. ncbi High interleukin-6 plasma levels are associated with functional impairment in older patients with vascular dementia
    G Zuliani
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, Italy
    Int J Geriatr Psychiatry 22:305-11. 2007
    ..forty older demented patients including 60 patients with late onset Alzheimer's disease (LOAD) and 80 with vascular dementia (VD)...
  99. ncbi Cytokines and cognition--the case for a head-to-toe inflammatory paradigm
    Craig J Wilson
    St Vincent Institute on Aging, St Vincent Hospitals and Health Services, Indianapolis, Indiana 46260, USA
    J Am Geriatr Soc 50:2041-56. 2002
    ..of cytokine-mediated inflammatory processes in neurodegenerative diseases such as Alzheimer's disease and vascular dementia. Consistent with their involvement as mediators of bidirectional communication between the CNS and the ..
  100. ncbi Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus
    Grant A Bateman
    Department of Medical Imaging, John Hunter Hospital, Newcastle Region Mail Centre, Locked Bag 1, Newcastle 2310, Australia
    Med Hypotheses 62:182-7. 2004
    The disorders of Alzheimer's disease, vascular dementia and normal pressure hydrocephalus are all causes of dementia in the elderly population. It is often the case that it is clinically very difficult to tell these diseases apart...
  101. ncbi Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer's disease and healthy aging
    L Gootjes
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Dement Geriatr Cogn Disord 18:180-8. 2004
    ..The regional distribution of WMH may be related to their pathophysiology and clinical effect in vascular dementia (VaD), Alzheimer's disease (AD) and healthy aging.

Research Grants63

  1. Safe, Rapid Telomere Extension to Prevent and Treat Hypertension
    Helen M Blau; Fiscal Year: 2013
    ..by short telomeres: hypertension and heart failure (Cooke and Blau labs), immunosenescence (Weyand lab), and vascular dementia (Yesavage lab) (see supporting letters)...
  2. Telomere extension using nucleoside-modified mRNA and exosomes as a novel therape
    Helen M Blau; Fiscal Year: 2013
    ..in our labs, Duchenne muscular dystrophy (DMD) and vascular disease, which includes atherosclerosis, vascular dementia, and heart disease...
  3. Effect of White Matter Disease on Gait and Balance in Cerebral Amyloid Angiopathy
    Anand Viswanathan; Fiscal Year: 2013
    ..NIH-funded clinical research study enrolling patients affected with all types of memory disorders, including vascular dementia and CAA. It was established by Dr. John Growdon and currently led by Dr...
  4. Domains of Inflammation and Risk of Dementia
    Annette L Fitzpatrick; Fiscal Year: 2013
    ..Subtype of dementia, i.e. AD and vascular dementia, were determined using MRI images and standardized criteria...
  5. O-linked glycosylation and synaptic function in hippocampus
    LORI LYNN contact MCMAHON; Fiscal Year: 2010
    ..and cognitive impairment;as such diabetics have an increased risk of Alzheimer's disease and vascular dementia. Under basal conditions, glucose is processed through the glycolytic pathway;while 2-4% is process via the ..
  6. Role of impaired cognitive states &risk factors in conversion to mixed dementias
    Lei Yu; Fiscal Year: 2013
    ..to dementia and differentiate Alzheimer's disease (AD) from other prevalent brain diseases that include vascular dementia (VaD) and Lewy body disease (LBD)...
  7. Fibrinogen as a molecular mediator of cognitive dysfunction
    Frances Alexandra Loucks; Fiscal Year: 2010
    ..levels of fibrinogen are linked to the onset of demetia(13) and increase the risk of developing AD and vascular dementia.(14) Studies in animal models show that fibrinogen contributes to neurological disease by exacerbating ..
  8. ASPirin in Reducing Events in the Elderly
    JOHN JAMES MCNEIL; Fiscal Year: 2013
    ..whether the potential benefits of this drug (particularly the prevention of heart disease, stroke and vascular dementia) outweigh the risks of severe bleeding in this age group...
  9. Failure of metabolite clearance in a model of multi-lacunar infarcts
    Maiken Nedergaard; Fiscal Year: 2013
    ..We will test the provocative hypothesis that cognitive function in an experimental model of vascular dementia in part is suppressed by accumulation of metabolic waste products...
  10. Structural studies of tight junction proteins
    John M Flanagan; Fiscal Year: 2013
    ..tumors), stroke, retinopathies, kidney disorders, irritable bowel syndrome, Alzheimer's disease and vascular dementia, and asthma. Moreover, TJ components are used as cellular receptors by a range of pathogens...
  11. Vascular Risk and Cognition in a Multi-ethnic Cohort
    Clinton B Wright; Fiscal Year: 2013
    ..These relationships are poorly understood because past definitions of vascular dementia evolved from those for Alzheimer disease...
  12. Role of Proteasome Inhibition in the Pathogenesis of CADASIL
    Michael M Wang; Fiscal Year: 2010
    Stroke and vascular dementia are prevalent diseases which are both caused by multiple factors, including genetic susceptibility. In large part, the genetics of these disorders is complex...
  13. BIOMEDICAL (BASIC)
    ALFED CHEUNG; Fiscal Year: 2009
    ..recommended will reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume;and (3) Diagnosis of probable dementia, to screen all SPRINT ..
  14. Oligo-Vascular Signaling in Stroke
    Ken Arai; Fiscal Year: 2013
    ..White matter injury is a central event in the pathophysiology of diverse CNS disorders, including stroke and vascular dementia. But studies that investigate white matter are relatively uncommon in cerebrovascular research...
  15. Dietary and Visceral Fat Regulate Vascular Amyloid Pathogenesis
    JEFFREY NEIL KELLER; Fiscal Year: 2012
    ..studies suggest that increased adiposity, and specifically visceral adiposity, elevates the risk of both vascular dementia and Alzheimer's disease (AD)...
  16. Inflammation and delayed cognitive dysfunction after stroke
    KRISTIAN PAUL DOYLE; Fiscal Year: 2013
    ..This dementia is commonly referred to as vascular dementia and its etiology is unknown...
  17. Notch, LRP, and MMP in Stroke and Vascular Dementia
    Michael M Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stroke and vascular dementia are important disabling disorders among the veteran population...
  18. Growth Hormone & IGF-1 in CNS and Cerebrovascular Aging
    William Edmund Sonntag; Fiscal Year: 2010
    ..between endocrine and microvascular changes and the neural substrates that contribute to cognitive decline, vascular dementia and increased susceptibility to diseases commonly observed in the elderly, including Alzheimer's ..
  19. Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapy
    Shaohua Yang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ischemic stroke is the major cause of vascular dementia. Epidemiological studies have suggested a progressive course of dementia after ischemia stroke...
  20. Epidemiology of Brain Aging in the Very Old
    LON RAY WHITE; Fiscal Year: 2011
    ..of Brain Aging in the Very Old", a population-based longitudinal study of Alzheimer's disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), mild cognitive impairment (MCI), and Parkinson's disease (PD)...
  21. Stroke &cognition in surgical aortic stenosis
    MICHAEL ANDREW ACKER; Fiscal Year: 2011
    ..multiple cerebral infarctions in the short- term, and may be at risk for an acceleration toward long-term vascular dementia. This is a key population in which to study not only the pathogenesis of stroke and POCD, but also one in ..
  22. Effects of Traffic-Related Air Pollution on Cognitive Function, Dementia Risk, an
    JOEL DANIEL KAUFMAN; Fiscal Year: 2011
    ..will include cognitive performance, prevalent and incident dementia (both Alzheimer's disease and vascular dementia), presence of MRI-detected brain abnormalities including brain infarcts and white matter disease, and ..
  23. Blood-Brain Barrier in Neuroinflammation
    ANUSKA V ANDJELKOVIC-ZOCHOWSKA; Fiscal Year: 2012
    ..BBB leaking is seen in many disease states like Alzheimer and Parkinson disease, vascular dementia, and epilepsy but also in the process of BBB recovery after ischemic episodes or inflammation...
  24. Influence of Age-related Neuropathology on Functional Brain Networks
    JULIUS C HEDDEN; Fiscal Year: 2013
    ..White matter integrity, commonly disrupted in vascular dementia, will be measured using structural magnetic resonance imaging (MRI)...
  25. Genetic Epidemiology of Cerebrovascular Disease and Cognition in Diabetes
    Donald W Bowden; Fiscal Year: 2012
    ..Dementia due to cerebrovascular disease is often referred to as vascular dementia" or vascular cognitive impairment (VCI)...
  26. Molecular Features of and Approach to the HIV CNS Reservoir Post cART
    MICHAEL SHANNON MCGRATH; Fiscal Year: 2013
    ..of atherosclerosis as a significant comorbidity in HIV-infected patients, it appears that a variation of vascular dementia may be becoming more frequent, implicating a potentially new type of HIV-associated CNS pathogenesis...
  27. Delayed cognitive impairment after stroke
    Marion S Buckwalter; Fiscal Year: 2013
    ..All-cause dementia, (vascular dementia, Alzheimer's disease, and mixed disorders) is diagnosed in up to 48% of stroke survivors, with about 20%..
  28. Mechanisms of Neural Repair in White Matter Stroke
    STANLEY THOMAS CARMICHAEL; Fiscal Year: 2013
    ..White matter strokes are a source of significant disability and can accumulate to cause vascular dementia, the second leading cause of dementia...
  29. SECONDARY PREVENTION OF SMALL SUBCORTICAL STROKES (SPS3)
    Oscar R Benavente; Fiscal Year: 2012
    ..S3 are usually due to small vessel disease, a common substrate for vascular dementia. Over two million survivors of S3 are at risk for recurrent stroke and for vascular dementia;millions more ..
  30. Secondary Prevention of Subcortical Stroke Prevention Genetic Substudy
    Alan R Shuldiner; Fiscal Year: 2013
    ..HEALTH RELEVANCE: Small subcortical strokes (S3) are a common stroke subtype and contribute importantly to vascular dementia. The SPS3 trial seeks to define optimal treatment approaches with antiplatelet and antihypertensive ..
  31. First Person Vision for Objective Evaluation of Caregiving Quality
    JUDITH T MATTHEWS; Fiscal Year: 2013
    ..MMSE score <18) due to Alzheimer's disease, frontal temporal dementia, Lewy body dementia, or vascular dementia. Baseline data will include demographic, health, and caregiving information including problem behaviors, ..
  32. Daily Functioning, Cognition, and Caregiver Burden in MCI Patients
    LALEH JILL RAZANI; Fiscal Year: 2013
    ..compared to a database of individuals with dementia (Alzhiemer's disease, Frontotemporal dementia, and Vascular dementia) and normal controls...
  33. Gene-Environment Interaction in Cognition in Venezuelan Families
    JOSEPH DOUGLAS TERWILLIGER; Fiscal Year: 2013
    ..Ischemic small vessel disease (SVD) is a leading cause of vascular dementia and a major contributor to Alzheimer's disease...
  34. Functional Decline in Three Dementia Types
    WALTER ANTHONY KUKULL; Fiscal Year: 2012
    ..research and clinical care as to expected rates of functional decline in Alzheimer's disease (AD), vascular dementia (VaD) and dementia with Lewy bodies (DLB), and differences among these dementia types...
  35. Dorsal Cingulate Activity and Cognitive Decline in Late-Life Depression
    Lihong Wang; Fiscal Year: 2013
    ..with cognitive decline over years have an increased risk of developing either Alzheimer's disease or vascular dementia. Identifying individuals who are at risk for developing cognitive decline is vital for early intervention ..
  36. Abnormal Low Density Lipoprotein Receptor Localization and Function in AD
    Huntington Potter; Fiscal Year: 2013
    ..roles that atherosclerosis and Abeta play in the pathogenesis of co-morbid Alzheimer's disease (AD) and vascular dementia. Although, most of the field's efforts have been focused on the role of LDL, ApoE and their receptors ..
  37. BIOMEDICAL (BASIC)
    David C Goff; Fiscal Year: 2009
    ..intervention wil reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume;and 3...
  38. PFC-MTL Interactions During Controlled Episodic Retrieval
    JENNIFER LEIGH BARREDO; Fiscal Year: 2012
    ..of neurological disease and a feature of many prevalent neuropsychological disorders such as ischemic vascular dementia and Alzheimer's and Parkinson's Diseases and the memory deficits that accompany healthy aging and ..
  39. ISOLATED EXECUTIVE IMPAIRMENT AND COGNITIVE DECLINE
    Julene K Johnson; Fiscal Year: 2010
    ..in future primary prevention and treatment trials, and 3) expand differential diagnosis with individuals who present with isolated executive impairment to include AD in addition to frontotemporal dementia, vascular dementia, etc.
  40. BIOMEDICAL (BASIC)
    Jackson Wright; Fiscal Year: 2009
    ..recommended will reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume;and (3) Diagnosis of probable dementia, to screen all SPRINT ..
  41. SPRINT
    Suzanne Oparil; Fiscal Year: 2009
    ..recommended will reduce the incidence of structural central nervous system abnormalities related to vascular dementia, and rate of decline in total brain volume;and (3) Diagnosis of probable dementia, to screen all SPRINT ..
  42. qBead Assessment of miRNA in Alzheimer's Disease
    Bruce E Seligmann; Fiscal Year: 2012
    ..disease and dementia (PD), patients with cerebrovascular disease neuropathologically diagnosed as vascular dementia (VaD), and normal controls (NC)...
  43. A Composite MR NeuroImaging Marker for Alzheimer's Disease
    Shi Jiang Li; Fiscal Year: 2013
    ..and distinguish mild AD from other types of non-AD dementia, such as frontotemporal dementia (FTD) and vascular dementia (VaD)...
  44. A platelet ligand mimetic for neurothrombotic disorders
    Catherine Woods; Fiscal Year: 2006
    ..complications in disorders such as thrombotic thrombocytopenic purpura (TTP), cerebral malaria, meningitis vascular dementia and Alzheimer's Disease (AD) where localized recruitment of activated platelets within the CNS ..
  45. EPIDEMIOLOGY OF DEMENTIA IN OLDER JAPANESE AMERICANS
    Eric Larson; Fiscal Year: 2000
    ..S. are similar, the relative prevalence of Alzheimer's disease (AD) to vascular dementia (VaD) is much greater in the U.S...
  46. TRANSGENIC MOUSE MODEL OF INCLUSION BODY MYOSITIS
    Frank LaFerla; Fiscal Year: 2001
    ..the first disease, other than those disorders related to Alzheimer's disease such as Down syndrome and vascular dementia, where pathological accumulation of the beta-amyloid peptide occurs outside the central nervous system...
  47. 18F-AV-133, A Novel Radiopharmaceutical for Differential Diagnosis of Dementia
    Franz Hefti; Fiscal Year: 2009
    ..with its most prevalent subforms Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular dementia, is a very substantial medical and societal problem...
  48. Chinese Dementia Care Research Center
    Sue Levkoff; Fiscal Year: 2009
    ..85% prevalence of Alzheimer's disease among individuals aged 65 and over, and a 1.1% prevalence of Vascular Dementia;thus, China is not a low risk nation for dementia...
  49. Cognitive Enhancers Explored with PET Imaging
    Susan Schultz; Fiscal Year: 2003
    ..g., vascular dementia) by establishing their effects on CNS hemodynamics and cognitive function in the elderly adult...
  50. VISUAL INTERVENTIONS TO IMPROVE ALZHEIMER COGNITION
    Alice Cronin Golomb; Fiscal Year: 2004
    ..young adults, and 160 demented patients, of whom 50% will be diagnosed with probable AD and 35 percent with Vascular Dementia. The remainder will include Lewy Body and Frontotemporal Dementias...
  51. Depression as a Risk Factor for Dementia
    JESSICA BROMMELHOFF; Fiscal Year: 2009
    ..Analyses will be conducted for total dementia and for Alzheimer's disease or vascular dementia alone...
  52. Varian 4 Tesla MRI/MRS for Neuro-degenerative Diseases
    Michael Weiner; Fiscal Year: 2002
    ..clinical collaborators have funded projects on normal aging, Alzheimer's disease, frontotemporal dementia, vascular dementia, Lewy Body disease, epilepsy, Parkinson's disease, amyotrophic lateral sclerosis, post traumatic stress ..
  53. HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTS
    SHARI WALDSTEIN; Fiscal Year: 2002
    DESCRIPTION: Hypertension is a major risk factor for cerebral infarction, intracranial hemorrhage, and vascular dementia, particularly among older adults...
  54. Notch3 signaling in small-artery-diseases
    Anne Joutel; Fiscal Year: 2009
    Small-vessel-diseases are a leading cause of Vascular Dementia. Our long-term goal is to elucidate the signaling pathways that control the structural and functional integrity of small arteries and understand the connections between these ..
  55. Cong Intl. Soc Vascular Behavioral & Cognitive Disorders
    ROBERT FRIEDLAND; Fiscal Year: 2005
    Interest in the vascular causes of various brain disorders including Alzheimer's disease, vascular dementia, mild cognitive impairment, depression, and other behavioral disorders has grown immensely over the last decade...
  56. AGGRESSION AND VIOLENCE IN COMMUNITY BASED AD FAMILIES
    Gregory Paveza; Fiscal Year: 1999
    ..Type according to DSM-III-R or Dementia of the Alzheimer's Type according to DSM-IV or with mixed AD and vascular dementia, with an initial diagnosis of AD or mixed AD made at least one year prior to being contacted for the study...
  57. Prevalence of Post-Stroke Dementia in Mexico
    Claudia Diaz; Fiscal Year: 2007
    ..and the United States, to determine the incidence, prevalence, risk factors and potential for prevention of vascular dementia and other forms of dementia in Mexico...
  58. Memory Impairment Screen and Decision Support CD-ROM
    ROBERT RAGER; Fiscal Year: 2001
    ..and telephone forms, shows high reliability, validity, sensitivity and specificity for preclinical AD and vascular dementia (VaD)...
  59. STRIATAL AMPA RECEPTOR PATHOLOGY IN SCHIZOPHRENIA
    JOHN NOGA; Fiscal Year: 2002
    ..presenting with psychotic symptoms and cognitive impairment such as schizophrenia, Alzheimer's disease, vascular dementia, and Parkinson's disease in which glutamatergic systems have been increasingly implicated in pathological ..
  60. ALCOHOL, AGING AND DEMENTIA--NEUROPSYCHOLOGICAL EFFECTS
    Judith Saxton; Fiscal Year: 2000
    ..applies to a number of disorders including Alzheimer's disease (AD) (the most frequent cause of dementia), Vascular dementia and Pick's disease...
  61. SUNDOWN SYNDROME IN A SKILLED NURSING FACILITY
    Donald Bliwise; Fiscal Year: 2002
    ..cycle and sleep/wakefulness in elderly patients with Alzheimer's Disease (AD), Parkinson's Disease (PD), Vascular Dementia (VasD) and aged matched controls...
  62. MMP-7 and SNARE Cleavage in Neuroinflammation
    Katherine Conant; Fiscal Year: 2009
    ..Moreover, elevated expression of MMPs has been reported in Alzheimer's disease, vascular dementia, and HIV-associated dementia...
  63. COGNITIVE CHANGE IN CEREBROVASCULAR DISEASE
    John Morris; Fiscal Year: 2000
    Cerebrovascular disease is a major cause of dementia and is potentially preventable. However, vascular dementia is poorly characterized and its true prevalence is unknown...