subarachnoid hemorrhage

Summary

Summary: Hemorrhage within the intracranial or spinal subarachnoid space, most often resulting from INTRACRANIAL ANEURYSM rupture or CRANIOCEREBRAL TRAUMA (see also SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurologic deficits, intraocular subhyaloid hemorrhages, and a reduced level of consciousness which may progress to coma or death. Spasm of intracranial arteries (see VASOSPASM, INTRACRANIAL) frequently accompanies this condition and may lead to BRAIN ISCHEMIA or CEREBRAL INFARCTION. (From N Engl J Med 1997 Jan 2;336(1):28-40)

Top Publications

  1. ncbi Aneurysmal subarachnoid hemorrhage
    Jose I Suarez
    Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    N Engl J Med 354:387-96. 2006
  2. pmc The importance of early brain injury after subarachnoid hemorrhage
    Fatima A Sehba
    The Departments of Neurosurgery and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Prog Neurobiol 97:14-37. 2012
  3. ncbi International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial
    Andrew Molyneux
    ISAT, Neurovascular Research Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 360:1267-74. 2002
  4. ncbi Subarachnoid haemorrhage
    Jan van Gijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584CX Utrecht, Netherlands
    Lancet 369:306-18. 2007
  5. ncbi Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling
    R Loch MacDonald
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    Stroke 43:1463-9. 2012
  6. ncbi Mechanisms of early brain injury after subarachnoid hemorrhage
    Julian Cahill
    Department of Physiology, Loma Linda University Medical School, Loma Linda, California 92354, USA
    J Cereb Blood Flow Metab 26:1341-53. 2006
  7. ncbi Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Stroke 41:2391-5. 2010
  8. ncbi Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects
    Mervyn D I Vergouwen
    Department of Medicine, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 42:924-9. 2011
  9. ncbi Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)
    R Loch MacDonald
    St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Lancet Neurol 10:618-25. 2011
  10. ncbi International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and
    Andrew J Molyneux
    Neurovascular Research Unit, Nuffield Department of Surgery, University of Oxford and Oxford Radcliffe Hospitals NHS Trust, Radcliffe Infirmary, Oxford, UK
    Lancet 366:809-17. 2005

Detail Information

Publications369 found, 100 shown here

  1. ncbi Aneurysmal subarachnoid hemorrhage
    Jose I Suarez
    Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    N Engl J Med 354:387-96. 2006
  2. pmc The importance of early brain injury after subarachnoid hemorrhage
    Fatima A Sehba
    The Departments of Neurosurgery and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Prog Neurobiol 97:14-37. 2012
    Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency that accounts for 5% of all stroke cases. Individuals affected are typically in the prime of their lives (mean age 50 years)...
  3. ncbi International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial
    Andrew Molyneux
    ISAT, Neurovascular Research Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 360:1267-74. 2002
    ..We undertook a randomised, multicentre trial to compare the safety and efficacy of endovascular coiling with standard neurosurgical clipping for such aneurysms judged to be suitable for both treatments...
  4. ncbi Subarachnoid haemorrhage
    Jan van Gijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584CX Utrecht, Netherlands
    Lancet 369:306-18. 2007
    ..Hydrocephalus might cause gradual obtundation in the first few hours or days; it can be treated by lumbar puncture or ventricular drainage, dependent on the site of obstruction...
  5. ncbi Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling
    R Loch MacDonald
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    Stroke 43:1463-9. 2012
    Clazosentan, an endothelin receptor antagonist, has been shown to reduce vasospasm after aneurysmal subarachnoid hemorrhage (aSAH)...
  6. ncbi Mechanisms of early brain injury after subarachnoid hemorrhage
    Julian Cahill
    Department of Physiology, Loma Linda University Medical School, Loma Linda, California 92354, USA
    J Cereb Blood Flow Metab 26:1341-53. 2006
    ..to a number of intracranial pathologies including stroke, Alzheimer's disease, and more recently subarachnoid hemorrhage (SAH)...
  7. ncbi Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group
    Mervyn D I Vergouwen
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Stroke 41:2391-5. 2010
    ..inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. A major cause for this inconsistency is the combining of radiographic evidence of vasospasm with ..
  8. ncbi Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects
    Mervyn D I Vergouwen
    Department of Medicine, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 42:924-9. 2011
    The pathogenesis of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage remains incompletely understood. It is generally assumed that it is caused by angiographic vasospasm...
  9. ncbi Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)
    R Loch MacDonald
    St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Lancet Neurol 10:618-25. 2011
    ..We investigated whether clazosentan reduced vasospasm-related morbidity and all-cause mortality...
  10. ncbi International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and
    Andrew J Molyneux
    Neurovascular Research Unit, Nuffield Department of Surgery, University of Oxford and Oxford Radcliffe Hospitals NHS Trust, Radcliffe Infirmary, Oxford, UK
    Lancet 366:809-17. 2005
    ..Here we present clinical outcomes 1 year after treatment...
  11. pmc Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought
    Ryszard M Pluta
    Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    Neurol Res 31:151-8. 2009
    ....
  12. pmc Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends
    N K de Rooij
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 78:1365-72. 2007
    ..To update our 1996 review on the incidence of subarachnoid haemorrhage (SAH) and assess the relation of incidence with region, age, gender and time period...
  13. pmc A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model
    Takashi Sugawara
    Department of Physiology, Loma Linda University, Loma Linda, CA 92350, United States
    J Neurosci Methods 167:327-34. 2008
    The endovascular perforation rodent model for experimental subarachnoid hemorrhage (SAH) studies is criticized for lack of control over bleeding...
  14. ncbi Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model
    Zhong Wang
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    J Pineal Res 53:129-37. 2012
    ..effects against early brain injury (EBI) by modulating cerebral oxidative stress after experimental subarachnoid hemorrhage (SAH); however, few investigations relate to the precise underlying molecular mechanisms...
  15. ncbi Transition of research focus from vasospasm to early brain injury after subarachnoid hemorrhage
    Basak Caner
    Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, California 92354, USA
    J Neurochem 123:12-21. 2012
    b>Subarachnoid hemorrhage is a devastating disease that can be difficult to manage...
  16. ncbi Impact of medical complications on outcome after subarachnoid hemorrhage
    Katja E Wartenberg
    Clinical Neuropsychology, New York Presbyterian Hospital, and Stroke and Critical Care, Columbia University, New York, NY, USA
    Crit Care Med 34:617-23; quiz 624. 2006
    Medical complications occur frequently after subarachnoid hemorrhage (SAH). Their impact on outcome remains poorly defined.
  17. ncbi Role of inflammation (leukocyte-endothelial cell interactions) in vasospasm after subarachnoid hemorrhage
    Kaisorn L Chaichana
    Division of Cerebrovascular Neurosurgery, Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    World Neurosurg 73:22-41. 2010
    Delayed vasospasm is the leading cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (aSAH)...
  18. ncbi Risk factors for subarachnoid hemorrhage: an updated systematic review of epidemiological studies
    Valery L Feigin
    Clinical Trials Research Unit, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    Stroke 36:2773-80. 2005
    After a 1996 review from our group on risk factors for subarachnoid hemorrhage (SAH), much new information has become available. This article provides an updated overview of risk factors for SAH.
  19. ncbi Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage
    Changman Zhou
    Department of Neurosurgery, Louisiana State University Health Sciences Center Shreveport, 71130 3932, USA
    J Cereb Blood Flow Metab 24:419-31. 2004
    ..of major cerebral arteries may play a role in the initiation and maintenance of cerebral vasospasm after subarachnoid hemorrhage (SAH)...
  20. ncbi Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage (IMASH): a randomized, double-blinded, placebo-controlled, multicenter phase III trial
    George Kwok Chu Wong
    FRCS, Department of Surgery Prince of Wales Hospital, Shatin, NT, Hong Kong 852, China
    Stroke 41:921-6. 2010
    Pilot clinical trials using magnesium sulfate in patients with acute aneurysmal subarachnoid hemorrhage have reported trends toward improvement in clinical outcomes...
  21. ncbi Neurovascular protection reduces early brain injury after subarachnoid hemorrhage
    S Park
    Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Stroke 35:2412-7. 2004
    Cell death, especially apoptosis, occurred in brain tissues after subarachnoid hemorrhage (SAH)...
  22. ncbi Delayed cerebral vasospasm and nitric oxide: review, new hypothesis, and proposed treatment
    Ryszard M Pluta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, 10 Center Drive, Room 5D37, MD 20892, USA
    Pharmacol Ther 105:23-56. 2005
    ..pathophysiology of delayed cerebral vasospasm remains poorly understood, (2) many experimental models of subarachnoid hemorrhage (SAH) do not mimic the actual clinical entity, and (3) many researchers erroneously extrapolate the data ..
  23. ncbi Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation
    Aaron S Dumont
    Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Neurosurgery 53:123-33; discussion 133-5. 2003
    ..is a common, formidable, and potentially devastating complication in patients who have sustained subarachnoid hemorrhage (SAH)...
  24. ncbi Case-fatality rates and functional outcome after subarachnoid hemorrhage: a systematic review
    J W Hop
    University Department of Neurology, Utrecht, Netherlands
    Stroke 28:660-4. 1997
    During the last three decades, new management strategies have been developed for patients with aneurysmal subarachnoid hemorrhage. To assess whether the case-fatality rate has improved after the introduction of new management strategies, ..
  25. ncbi Acute focal neurological deficits in aneurysmal subarachnoid hemorrhage: relation of clinical course, CT findings, and metabolite abnormalities monitored with bedside microdialysis
    Asita Sarrafzadeh
    Department of Neurosurgery, Virchow Medical Clinic, Humboldt University of Berlin, Berlin, Germany
    Stroke 34:1382-8. 2003
    ..metabolic markers for the development of (ir)reversible neurological deficits and cerebral infarction in subarachnoid hemorrhage (SAH) patients by using the microdialysis technique and (2) to evaluate the influence of intracerebral ..
  26. pmc Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury
    Fatima A Sehba
    Department of Neurosurgery, Mount Sinai School of Medicine, Box 1136, New York, NY 10029, USA
    Mol Neurobiol 43:27-40. 2011
    Delayed vasospasm that develops 3-7 days after aneurysmal subarachnoid hemorrhage (SAH) has traditionally been considered the most important determinant of delayed ischemic injury and poor outcome...
  27. ncbi Risk factors for aneurysmal subarachnoid hemorrhage in a prospective population study: the HUNT study in Norway
    Marie Søfteland Sandvei
    Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Stroke 40:1958-62. 2009
    The morbidity and mortality of subarachnoid hemorrhage (SAH) are high, and established risk factors are scarce. We prospectively assessed the association of blood pressure, smoking, and body mass with the risk of aneurysmal SAH.
  28. pmc Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage
    Johannes Woitzik
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Cereb Blood Flow Metab 32:203-12. 2012
    ..hypothesized that vasospasm is the prime mechanism of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Recently, it was found that clusters of spreading depolarizations (SDs) are associated with DCI...
  29. pmc Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up
    Andrew J Molyneux
    Neurovascular Research Unit, Nuffield Department of Surgery, University of Oxford and Oxford Radcliffe Hospitals NHS Trust, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 8:427-33. 2009
    ....
  30. ncbi Learning deficits after experimental subarachnoid hemorrhage in rats
    H Jeon
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital and Department of Surgery, University of Toronto, Ontario, Canada
    Neuroscience 169:1805-14. 2010
    About 50% of subarachnoid hemorrhage (SAH) survivors have cognitive or neurobehavioral dysfunction. The mechanisms are not known...
  31. pmc Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice
    Orhan Altay
    Department of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA 92354, USA
    Stroke 43:2513-6. 2012
    We examined effects of isoflurane, volatile anesthetics, on blood-brain barrier disruption in the endovascular perforation model of subarachnoid hemorrhage (SAH) in mice.
  32. pmc Cell death starts early after subarachnoid hemorrhage
    Victor Friedrich
    Neuroscience, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1065, New York, NY 10029, USA
    Neurosci Lett 512:6-11. 2012
    Brain injury begins early after aneurysmal subarachnoid hemorrhage (SAH). Although cell death via apoptosis and necrosis is known to be present in brain 24 h after SAH, it is not known how soon after SAH cell death begins...
  33. ncbi Delayed cell death related to acute cerebral blood flow changes following subarachnoid hemorrhage in the rat brain
    Giselle F Prunell
    Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, Stockholm, Sweden
    J Neurosurg 102:1046-54. 2005
    The authors tested the hypotheses that subarachnoid hemorrhage (SAH) leads to delayed cell death with the participation of apoptotic-like mechanisms and is influenced by the degree of acute decrease in the cerebral blood flow (CBF) ..
  34. ncbi Long-term outcomes of patients with aneurysmal subarachnoid haemorrhage
    Gabriel J E Rinkel
    Utrecht Stroke Center, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Lancet Neurol 10:349-56. 2011
    ..The course of associated long-term physical and cognitive deficits after aSAH is not well established, leading to questions about potential outcomes to quality of life and working capacity, as well as best clinical practices...
  35. ncbi Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats
    Hidenori Endo
    Department of Neurosurgery, and Program in Neurosciences, Stanford University School of Medicine, 1201 Welch Rd, MSLS P314, Stanford, California 94305 5487, USA
    Stroke 37:2140-6. 2006
    Apoptotic cell death is associated with acute brain injury after subarachnoid hemorrhage (SAH)...
  36. ncbi Subarachnoid haemorrhage: diagnosis, causes and management
    J van Gijn
    Department of Neurology, University Medical Centre, Utrecht, The Netherlands
    Brain 124:249-78. 2001
    ..Once ischaemia has occurred, treatment regimens such as a combination of induced hypertension and hypervolaemia, or transluminal angioplasty, are plausible, but of unproven benefit...
  37. ncbi Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage
    Gang Chen
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    J Neurosci Res 89:515-23. 2011
    ..and oxidative damage, which are involved in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH)...
  38. ncbi Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage
    Matthew J McGirt
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosurg 98:1222-6. 2003
    The identification of patients at an increased risk for cerebral vasospasm after subarachnoid hemorrhage (SAH) may allow for more aggressive treatment and improved patient outcomes...
  39. ncbi Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage
    Ryszard M Pluta
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 293:1477-84. 2005
    ..Decreased bioavailability of nitric oxide has been associated with the development of cerebral vasospasm...
  40. pmc Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice
    Takumi Sozen
    Department of Physiology, Loma Linda University of Medicine, Loma Linda, CA 92354, USA
    Stroke 40:2519-25. 2009
    The role of interleukin (IL)-1beta remains unknown in early brain injury (EBI) after subarachnoid hemorrhage (SAH), although IL-1beta has been repeatedly reported to increase in the brain and cerebrospinal fluid...
  41. ncbi Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    Stroke 36:1627-32. 2005
    ..randomized controlled trial was conducted to examine the hypothesis that acute pravastatin treatment could improve cerebrovascular autoregulation and reduce vasospasm-related complications after aneurysmal subarachnoid hemorrhage (SAH).
  42. ncbi Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations
    Jens P Dreier
    Department of Experimental Neurology and Neurology, Charite University Medicine, Berlin, Germany
    Brain 129:3224-37. 2006
    ..In view of experimental evidence and the present clinical results, we suggest that spreading depolarizations with prolonged depressions are a promising target for treatment development in SAH and ischaemic stroke...
  43. ncbi Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial
    R Loch MacDonald
    St Michael s Hospital, Division of Neurosurgery, Toronto, Ontario, Canada
    Stroke 39:3015-21. 2008
    ..double-blind, placebo-controlled, dose-finding study assessed efficacy and safety of 1, 5, and 15 mg/h intravenous clazosentan, an endothelin receptor antagonist, in preventing vasospasm after aneurysmal subarachnoid hemorrhage.
  44. pmc Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    J Cereb Blood Flow Metab 29:317-30. 2009
    b>Subarachnoid hemorrhage (SAH) causes secondary brain injury due to vasospasm and inflammation...
  45. pmc Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage
    Jens P Dreier
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Brain 132:1866-81. 2009
    ....
  46. ncbi Flat-panel detector volumetric CT for visualization of subarachnoid hemorrhage and ventricles: preliminary results compared to conventional CT
    M Doelken
    Department of Neuroradiology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neuroradiology 50:517-23. 2008
    The aim of this study was to compare flat-panel volumetric CT (VCT) to conventional CT (cCT) in the visualization of the extent of subarachnoid hemorrhage (SAH) and the width of the ventricles in patients with acute SAH.
  47. ncbi NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat
    Antonino Germanò
    Neurosurgical Clinic, Department of Neurosciences, Psychiatry and Anaesthesiology, University of Messina School of Medicine, Messina, Italy
    J Neurotrauma 24:732-44. 2007
    Increased levels of glutamate and aspartate have been detected after subarachnoid hemorrhage (SAH) that correlate with neurological status...
  48. ncbi Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage
    Gang Chen
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
    Cytokine 45:162-8. 2009
    ..human erythropoietin (rhEPO) can attenuate the degree of cerebral vasospasm following experimental subarachnoid hemorrhage (SAH). However, the mechanisms for this beneficial effect are still poorly understood...
  49. ncbi Signaling mechanisms in cerebral vasospasm
    Shigeru Nishizawa
    Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Trends Cardiovasc Med 15:24-34. 2005
    The elusive nature of events that sustain cerebral vasospasm after subarachnoid hemorrhage resulting from a ruptured aneurysm presents major challenges in designing effective therapies for this frequently devastating condition...
  50. ncbi Microthrombosis after experimental subarachnoid hemorrhage: time course and effect of red blood cell-bound thrombin-activated pro-urokinase and clazosentan
    Jared M Pisapia
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 233:357-63. 2012
    ..In this study we investigate the time course of intravascular microclot formation after experimental subarachnoid hemorrhage (SAH) and assess the effects of the following two drugs on microclot burden: mutant thrombin-activated ..
  51. ncbi Dynamic alterations of cerebral pial microcirculation during experimental subarachnoid hemorrhage
    Bao Liang Sun
    Department of Neurology and Institute of Microcirculation, Affiliated Hospital, Taishan Medical College, No 706, Taishan Avenue, Taian, Shandong 271000, China
    Cell Mol Neurobiol 29:235-41. 2009
    The study aimed to investigate the involvement of cerebral microcirculation turbulence after subarachnoid hemorrhage (SAH). Wistar rats were divided into non-SAH and SAH groups...
  52. ncbi Mechanisms of acute brain injury after subarachnoid hemorrhage
    Fatima A Sehba
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Neurol Res 28:381-98. 2006
    Brain injury after subarachnoid hemorrhage (SAH) is a biphasic event with an acute ischemic insult at the time of the initial bleed and secondary events such as cerebral vasospasm 3 to 7 days later...
  53. ncbi Impact of cerebral microcirculatory changes on cerebral blood flow during cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    H Ohkuma
    Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Stroke 31:1621-7. 2000
    Cerebral microcirculatory changes during cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) are still controversial and uncertain...
  54. ncbi Subarachnoid hemorrhage incidence in the United States does not vary with season or temperature
    R J McDonald
    Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    AJNR Am J Neuroradiol 33:1663-8. 2012
    ..In an effort to identify a seasonal effect, variation in SAH incidence and in-hospital mortality rates were examined as they relate to admission month, temperature, and climate using HCUP's Nationwide Inpatient Sample...
  55. pmc Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits
    Zong Zhuang
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China
    BMC Neurosci 13:47. 2012
    Increasing experimental and clinical data indicate that early brain injury (EBI) after subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes, and it has been proved that EBI following SAH is closely associated with ..
  56. ncbi Autophagy activation is associated with neuroprotection against apoptosis via a mitochondrial pathway in a rat model of subarachnoid hemorrhage
    C H Jing
    Department of Neurosurgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    Neuroscience 213:144-53. 2012
    ..A recent study showed that autophagy was activated in the phase of early brain injury following subarachnoid hemorrhage (SAH). However, whether autophagy activation after SAH is protective or harmful is still elusive...
  57. ncbi Real-time imaging of subarachnoid hemorrhage in piglets with electrical impedance tomography
    Meng Dai
    Department of Biomedical Engineering, Fourth Military Medical University, Xi an 710032, People s Republic of China
    Physiol Meas 31:1229-39. 2010
    b>Subarachnoid hemorrhage (SAH) is one of the most severe medical emergencies in neurosurgery. Early detection or diagnosis would significantly reduce the rate of disability and mortality, and improve the prognosis of the patients...
  58. ncbi Role of bedside microdialysis in the diagnosis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage
    A W Unterberg
    Department of Neurosurgery and Radiology, Charite, Humboldt University, Berlin, Germany
    J Neurosurg 94:740-9. 2001
    Ischemia due to vasospasm is a feared complication in patients following aneurysmal subarachnoid hemorrhage (SAH)...
  59. ncbi Neuroprotective effects of anti-tumor necrosis factor-alpha antibody on apoptosis following subarachnoid hemorrhage in a rat model
    Yong Jiang
    Department of Neurosurgery, Jinan Central Hospital affiliated to Shandong University, Shandong University, 105 Jiefang Road, Jinan, Shandong 250013, China
    J Clin Neurosci 19:866-72. 2012
    Recent studies have emphasized the importance of apoptosis in subarachnoid hemorrhage (SAH) and the subsequent early brain injury. However, the apoptotic pathways induced by SAH in different brain regions are not fully understood...
  60. pmc Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in Li Ka Shing Knowledge Institute of St Michael s Hospital and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:190-9. 2011
    ..endothelial nitric oxide synthase (eNOS) is upregulated and uncoupled in large cerebral arteries after subarachnoid hemorrhage (SAH) and also whether this causes cerebral vasospasm in a mouse model of anterior circulation SAH...
  61. ncbi Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcome
    Jan Claassen
    Division of Critical Care Neurology, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 33:1225-32. 2002
    Cerebral edema visualized by CT is often seen after subarachnoid hemorrhage (SAH). Inflammatory or circulatory mechanisms have been postulated to explain this radiographic observation after SAH...
  62. pmc Endothelial nitric oxide synthase mediates endogenous protection against subarachnoid hemorrhage-induced cerebral vasospasm
    Ananth K Vellimana
    Department of Neurological Surgery, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Stroke 42:776-82. 2011
    ..Vasospasm-induced delayed cerebral ischemia remains a major source of morbidity in patients with aneurysmal subarachnoid hemorrhage (SAH)...
  63. ncbi Tumor necrosis factor-alpha mediates hemolysis-induced vasoconstriction and the cerebral vasospasm evoked by subarachnoid hemorrhage
    Carmine Vecchione
    Department of AngioCardioNeurology, Neuromed Institute IRCCS, Pozzilli, Italy
    Hypertension 54:150-6. 2009
    Hypertension can lead to subarachnoid hemorrhage and eventually to cerebral vasospasm. It has been suggested that the latter could be the result of oxidative stress and an inflammatory response evoked by subarachnoid hemorrhage...
  64. ncbi Clinical prediction models for aneurysmal subarachnoid hemorrhage: a systematic review
    Blessing N R Jaja
    St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Neurocrit Care 18:143-53. 2013
    ..However, available prediction models in aneurysmal subarachnoid hemorrhage (aSAH) are rarely used...
  65. ncbi Acute lung injury associated with systemic inflammatory response syndrome following subarachnoid hemorrhage: a survey by the Shonan Neurosurgical Association
    Yoshihisa Kitamura
    Department of Neurosurgery, Yokohama Sakae Kyosai Hospital, Yokohama, Kanagawa, Japan
    Neurol Med Chir (Tokyo) 50:456-60. 2010
    ..ALI) associated with systemic inflammatory response syndrome (SIRS) is a systemic complication following subarachnoid hemorrhage (SAH), but the incidence and influence on prognosis are unclear...
  66. ncbi Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage
    R Webster Crowley
    Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA
    Stroke 42:919-23. 2011
    The long-standing concept that delayed cerebral infarction after aneurysmal subarachnoid hemorrhage results exclusively from large artery vasospasm recently has been challenged...
  67. ncbi Mechanisms of microthrombi formation after experimental subarachnoid hemorrhage
    M Sabri
    Institute of Medical Science, University of Toronto, Ontario, Canada
    Neuroscience 224:26-37. 2012
    Microcirculatory dysfunction may contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH)...
  68. ncbi Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference
    Michael N Diringer
    Neurology Neurosurgery Intensive Care Unit, Washington University, St Louis, MO, USA
    Neurocrit Care 15:211-40. 2011
    b>Subarachnoid hemorrhage (SAH) is an acute cerebrovascular event which can have devastating effects on the central nervous system as well as a profound impact on several other organs...
  69. ncbi Hemodynamic management of subarachnoid hemorrhage
    Miriam M Treggiari
    Department of Anesthesiology and Pain Medicine, University of Washington, Box 359724, Seattle, WA, USA
    Neurocrit Care 15:329-35. 2011
    ..between 2000 and October 2010 that focused on hemodynamic augmentation therapies in patients with subarachnoid hemorrhage. Among the eligible reports identified, 11 addressed volume expansion, 10 blood pressure management, 4 ..
  70. ncbi Magnesium sulfate in the management of patients with aneurysmal subarachnoid hemorrhage: a randomized, placebo-controlled, dose-adapted trial
    Carl Muroi
    Department of Neurosurgery, University Hospital Zurich, Zurich CH 8091, Switzerland
    Surg Neurol 69:33-9; discussion 39. 2008
    ..We intended to assess the safety and efficacy of high-dose MgSO4 therapy after SAH as means to prevent DIND and to evaluate the impact on clinical outcome...
  71. ncbi Inflammation in the brain after experimental subarachnoid hemorrhage
    Giselle F Prunell
    Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, Stockholm, Sweden
    Neurosurgery 56:1082-92; discussion 1082-92. 2005
    To study the occurrence of an inflammatory response in the brain after subarachnoid hemorrhage and its relation to the decrease in acute cerebral blood flow, subarachnoid blood proximity, and cell damage.
  72. pmc Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    BMC Neurosci 12:107. 2011
    Late cerebral ischemia carries high morbidity and mortality after subarachnoid hemorrhage (SAH) due to reduced cerebral blood flow (CBF) and the subsequent cerebral ischemia which is associated with upregulation of contractile receptors ..
  73. ncbi The anti-inflammatory and neuroprotective effects of ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats
    Mehmet Ersahin
    Haydarpasa Numune Education and Research Hospital, Department of Neurosurgery, Istanbul, Turkey
    J Neurotrauma 27:1143-55. 2010
    To elucidate the putative neuroprotective effects of ghrelin in subarachnoid hemorrhage (SAH)-induced brain injury, Wistar albino rats (n = 54) were divided into sham-operated control, saline-treated SAH, and ghrelin-treated (10 microg/..
  74. ncbi Stent-assisted coiling in acutely ruptured intracranial aneurysms: a qualitative, systematic review of the literature
    K D Bodily
    Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA
    AJNR Am J Neuroradiol 32:1232-6. 2011
    ..Our aim was to review the literature regarding stent-assisted coil embolization of acutely ruptured intracranial aneurysms to determine the safety and efficacy of this treatment option...
  75. ncbi Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhage
    Joseph F Clark
    Department of Neurology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, Ohio 45267 0536, USA
    J Cereb Blood Flow Metab 26:1223-33. 2006
    Many factors have been postulated to cause delayed subarachnoid hemorrhage (SAH)-induced vasospasm, including hemoglobin, nitric oxide, endothelin, and free radicals...
  76. pmc Subarachnoid hemorrhage: is it time for a new direction?
    Julian Cahill
    Division of Neurosurgery, Loma Linda University Medical Center, 11234 Anderson St, Room 2562B, Loma Linda, CA 92354, USA
    Stroke 40:S86-7. 2009
    Despite recent advances in the treatment of patients after subarachnoid hemorrhage, morbidity and mortality rates have failed to improve significantly...
  77. ncbi Potential contribution of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 to blood-brain barrier disruption and brain edema after experimental subarachnoid hemorrhage
    Zhong Wang
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, People s Republic of China
    J Mol Neurosci 48:273-80. 2012
    ..MMP-9) in blood-brain barrier (BBB) dysfunction and cerebral edema formation in a rat subarachnoid hemorrhage (SAH) model. The SAH model was induced by injection of 0...
  78. ncbi Defining vasospasm after subarachnoid hemorrhage: what is the most clinically relevant definition?
    Jennifer A Frontera
    Mount Sinai School of Medicine, Department of Neurosurgery, One Gustave Levy Place, Box 1136, New York, NY 10029, USA
    Stroke 40:1963-8. 2009
    Vasospasm is an important complication of subarachnoid hemorrhage, but is variably defined in the literature.
  79. ncbi Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial
    John R Lynch
    Departments of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 36:2024-6. 2005
    Cerebral vasospasm remains a major source of morbidity after aneurysmal subarachnoid hemorrhage (SAH). We demonstrate that simvastatin reduces serum markers of brain injury and attenuates vasospasm after SAH.
  80. pmc Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage
    Salah G Keyrouz
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, South Euclid Avenue, St Louis, MO 63110, USA
    Crit Care 11:220. 2007
    Vasospasm is one of the leading causes of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH)...
  81. ncbi Wide-necked intracranial aneurysms: treatment with stent-assisted coil embolization during acute (<72 hours) subarachnoid hemorrhage--experience in 61 consecutive patients
    Olli I Tähtinen
    Department of Diagnostic Radiology, Tampere University Hospital, 33521 Tampere, Finland
    Radiology 253:199-208. 2009
    To evaluate the safety and efficacy of stent-assisted embolization of ruptured wide-necked intracranial aneurysms during acute subarachnoid hemorrhage (SAH).
  82. ncbi Cerebrovascular inflammation following subarachnoid hemorrhage
    Richard Sercombe
    Laboratoire de Recherches Cerebrovasculaires, CNRS UPR 646, IFR Circulation Lariboisiere, Universite Paris VI, Faculté de Médecine Lariboisière St Louis, Paris, France
    Jpn J Pharmacol 88:227-49. 2002
    Aneurysmal subarachnoid hemorrhage frequently results in complications including intracranial hypertension, rebleeding and vasospasm...
  83. ncbi Mild intraoperative hypothermia during surgery for intracranial aneurysm
    Michael M Todd
    Department of Anesthesia, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    N Engl J Med 352:135-45. 2005
    ..We conducted a randomized trial at 30 centers to determine whether intraoperative cooling during open craniotomy would improve the outcome among patients with acute aneurysmal subarachnoid hemorrhage.
  84. ncbi Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter phase IIa study
    Peter Vajkoczy
    Department of Neurosurgery, University Hospital Mannheim, and Faculty for Clinical Medicine, Karl Ruprecht University of Heidelberg, Mannheim, Switzerland
    J Neurosurg 103:9-17. 2005
    ..safety and tolerability of the novel endothelin A (ETA) receptor antagonist clazosentan in patients with subarachnoid hemorrhage (SAH) and its potential to reduce the incidence and severity of cerebral vasospasm following surgical ..
  85. ncbi Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
    Am J Physiol Heart Circ Physiol 293:H3750-8. 2007
    ..underlying molecular mechanisms with the reduction in regional and global cerebral blood flow (CBF) after subarachnoid hemorrhage (SAH). SAH was induced by injecting 250 microl blood into the prechiasmatic cistern in rats...
  86. ncbi Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage
    Paul Klimo
    Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132 2303, USA
    J Neurosurg 100:215-24. 2004
    Cerebral vasospasm after subarachnoid hemorrhage (SAH) continues to be a major source of morbidity in patients despite significant clinical and basic science research...
  87. ncbi Comparison of telephone and face-to-face assessment of the modified Rankin Scale
    Paula M Janssen
    Department of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 29:137-9. 2010
    ..We assessed the validity of a telephone interview in patients who had had an aneurysmal subarachnoid haemorrhage (SAH) by comparing it with a face-to-face assessment...
  88. ncbi Prophylactic intravenous magnesium sulfate for treatment of aneurysmal subarachnoid hemorrhage: a randomized, placebo-controlled, clinical study
    Thomas Westermaier
    Department of Neurosurgery, University of Wuerzburg, Wuerzburg, Germany
    Crit Care Med 38:1284-90. 2010
    To examine whether the maintenance of elevated magnesium serum concentrations by intravenous administration of magnesium sulfate can reduce the occurrence of cerebral ischemic events after aneurysmal subarachnoid hemorrhage.
  89. ncbi Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage
    Hiroshi Yatsushige
    Department of Physiology, Loma Linda University, Loma Linda, California 92354, USA
    J Neurosci Res 85:1436-48. 2007
    ..N-terminal kinase (JNK) is induced by cerebral ischemia and injurious blood components acutely after subarachnoid hemorrhage (SAH)...
  90. pmc Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury
    Jin Yul Lee
    Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    J Cereb Blood Flow Metab 30:1793-803. 2010
    The purpose of this study was to investigate hemoglobin and iron handling after subarachnoid hemorrhage (SAH), examine the relationship between iron and neuroglial cell changes, and determine whether deferoxamine (DFX) can reduce SAH-..
  91. ncbi Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage
    Michael M Todd
    Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA michael
    Neurosurgery 64:897-908; discussion 908. 2009
    ..We examined the incidence of perioperative fever and its relationship to outcome among patients enrolled in the Intraoperative Hypothermia for Aneurysm Surgery Trial...
  92. ncbi Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage
    Carla S Jung
    National Institute of Neurological Disorders and Stroke, and National Institute of Alcohol Abuse and Alcoholism and National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 101:836-42. 2004
    ..The goal of this study was to determine whether ADMA levels are associated with cerebral vasospasm in a primate model of SAH...
  93. ncbi Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome
    Serge C Thal
    Institute for Surgical Research, University of Munich Medical Center Grosshadern, Munich, Germany
    Crit Care Med 37:2228-34. 2009
    Brain edema following subarachnoid hemorrhage (SAH) is a result of impairment of cerebral autoregulation and breakdown of the blood-brain barrier...
  94. ncbi Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Stroke 42:1454-60. 2011
    ..receptor antagonists such as clazosentan decrease large-artery vasospasm after experimental and clinical subarachnoid hemorrhage. We used clazosentan to gain insight into the pathophysiology of subarachnoid hemorrhage by determining ..
  95. ncbi Patient age and vasospasm after subarachnoid hemorrhage
    Mats Ryttlefors
    Department of Neuroscience, Section for Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    Neurosurgery 67:911-7. 2010
    b>Subarachnoid hemorrhage (SAH) from a ruptured intracranial aneurysm is a devastating disease with high mortality and morbidity. The incidence of SAH increases with advancing age.
  96. ncbi Risk of ventriculostomy-related hemorrhage in patients with acutely ruptured aneurysms treated using stent-assisted coiling
    David K Kung
    Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    J Neurosurg 114:1021-7. 2011
    ..The aim of this study was to directly quantify the risk of ventriculostomy-related hemorrhage in patients with acute aneurysmal subarachnoid hemorrhage treated with stent-assisted coiling.
  97. pmc Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis
    Nima Etminan
    Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:1443-51. 2011
    As it is often assumed that delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is caused by vasospasm, clinical trials often focus on prevention of vasospasm with the aim to improve clinical outcome...
  98. ncbi Initial clinical experience of vasodilatory effect of intra-cisternal infusion of magnesium sulfate for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    Kentaro Mori
    Department of Neurosurgery, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka, Japan
    Neurol Med Chir (Tokyo) 49:139-44; discussion 144-5. 2009
    ..of magnesium sulfate solution was evaluated in 10 patients with symptomatic vasospasm after aneurysmal subarachnoid hemorrhage (SAH) who underwent early clipping surgery...
  99. ncbi Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study
    Asita S Sarrafzadeh
    Charité Campus Virchow Medical Clinic, Humboldt University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Stroke 35:638-43. 2004
    Cerebral microdialysis (MD) is discussed as a technique for detection of cerebral ischemia in subarachnoid hemorrhage; however, clinical data on cerebral blood flow (CBF) are limited in these patients...
  100. pmc Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone
    Masayo Koide
    Department of Pharmacology, University of Vermont College of Medicine, Burlington, Vermont, USA
    J Cereb Blood Flow Metab 31:3-16. 2011
    ..Considering the frequent occurrence of cerebral artery constriction after subarachnoid hemorrhage (SAH), our objective was to determine whether Ca(2+) spark and BK channel activity were reduced in ..
  101. ncbi Expression of HGF and VEGF in the cerebral tissue of adult rats with chronic hydrocephalus after subarachnoid hemorrhage
    Sheng Hua Chu
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201900, P R China
    Mol Med Rep 4:785-91. 2011
    ..role and expression of HGF and VEGF in the cerebral tissue of adult rats with chronic hydrocephalus after subarachnoid hemorrhage. Adult female Wistar rats were randomly divided into 4 groups: a control group (n=20) and 3 experimental ..

Research Grants65

  1. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..Obstructive sleep apnea may also result in the development of hypertension, cerebral and subarachnoid hemorrhage, and ventricular arrhythmias...
  2. Research Center for Pharmacology &Drug Toxicology
    L Jackson Roberts; Fiscal Year: 2013
    ..ability of acetaminophen to inhibit hemoglobin redox cycling induced lipid peroxidation in patients with subarachnoid hemorrhage and the second project will evaluate the ability of acetaminophen to inhibit hemoglobin and myoglobin ..
  3. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..GCS motor score, pupillary reaction, hypoxia, hypotension, initial head CT classification, traumatic subarachnoid hemorrhage or epidural mass on CT, serum glucose, and serum hemoglobin) in predicting GOS- E...
  4. RESEARCH CENTER FOR PHARMACOLOGY AND DRUG TOXICOLOGY
    L Jackson Roberts; Fiscal Year: 2010
    ..studies will evaluate the inhibition of lipid peroxidation by acetaminophen-based regimens in humans with subarachnoid hemorrhage. 4-hydroxynonenal is a bioactive lipid derived from the fragmentation of peroxidized polyunsaturated ..
  5. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..animal models of a variety of neurological disorders such as traumatic brain injury, spinal cord injury, subarachnoid hemorrhage and multiple sclerosis, implicating a therapeutic efficacy for these diseases...
  6. Modulating Secondary Damage Following Traumatic Brain Injury in the Child
    Stuart H Friess; Fiscal Year: 2013
    ..a clinically relevant pediatric porcine model of non-impact inertial head injury with subdural and subarachnoid hemorrhage, infarction, ischemia, and diffuse axonal injury, consistent with typical severe pediatric TBI...
  7. Role of P450 Eicosanoids in Delayed Microvascular Spasm Following Subarachnoid He
    DOMINIC AARON SILER; Fiscal Year: 2013
    ..A particularly devastating form of this illness, subarachnoid hemorrhage (SAH), represents 25% of life years lost among all forms of stroke due to the relatively young age of its ..
  8. Development of Potent/Selective Lipoxygenase Therapeutics Against Stroke Injury
    Theodore R Holman; Fiscal Year: 2013
    ..increased levels of the 12/15-LOX metabolite 12-HETE have been found in patients with stroke caused by subarachnoid hemorrhage, suggesting 12/15-LOX may be a target for subarachnoid hemorrhage as well...
  9. Mechanisms of Brain Injury after Intraventricular Hemorrhage
    Guohua Xi; Fiscal Year: 2013
    ..provided by applicant): Intraventricular hemorrhage (IVH) occurs in many patients with intracerebral and subarachnoid hemorrhage (SAH)...
  10. Development and Validation of a Diagnostic Tool for Infant Head Injuries from Fal
    SUSAN SHEPS contact MARGULIES; Fiscal Year: 2010
    ..In Aim 1, biomechanical tolerances of extra-axial hemorrhage (subdural and subarachnoid hemorrhage) are determined by using a porcine computational model to simulate non-impact rapid head rotation ..
  11. The Role of Mast Cells in the Pathophysiology of Intracranial Aneurysm
    Tomoki Hashimoto; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Subarachnoid hemorrhage resulting from aneurysmal rupture causes severe morbidity and high mortality. The management of unruptured intracranial aneurysms remains controversial...
  12. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Subarachnoid hemorrhage (SAH) affects over 30,000 Americans per year and is one of the major causes of stroke-related potential life-years lost in people age 65 and younger...
  13. Endothelial Ca2+ signals and vasodilatory function after traumatic brain injury
    Kalev Freeman; Fiscal Year: 2013
    ..Wellman adds expertise in animal models of brain trauma due to subarachnoid hemorrhage. This research environment maximizes the potential for the Candidate to establish a scientific niche from ..
  14. Neurovascular Protection for Early Brain Injury after SAH
    John H Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In our previous grant period (Neurovascular Protection for Subarachnoid Hemorrhage, NIH/NS053407 2007- 2011) we have studied endothelial protective mechanisms against cerebral vasospasm and brain ..
  15. Brain injury due to transcranial versus transthoracic blast exposure
    J Marc Simard; Fiscal Year: 2013
    ..indirect blast injury will be significantly different, with subarachnoid hemorrhage and injury to raphe neurons predisposing to post- traumatic stress disorder (PTSD)-like symptoms ..
  16. Cerebral Aneurysm Clipping Training Simulator using Virtual Reality and Haptics
    P Pat Banerjee; Fiscal Year: 2010
    ..new simulation of cerebral aneurysm clipping for training neurosurgeons in the treatment or prevention of subarachnoid hemorrhage and other forms of stroke...
  17. Mechanisms of early brain injury after subarachnoid hemmorrhage
    Guohua Xi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Subarachnoid hemorrhage (SAH) is a common subtype of stroke and the mortality rate is high (~35%) in the first several days...
  18. Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara
    J Marc Simard; Fiscal Year: 2013
    ..last 5 decades, cerebral vasospasm has been thought to be the principal cause of poor outcome following subarachnoid hemorrhage (SAH)...
  19. Phase II Trial of Tiopronin in Aneurysmal Subarachnoid Hemorrhage
    EDWARD SANDER CONNOLLY; Fiscal Year: 2011
    ..This would spark further study that could further explore neuroprotective pre-treatment of cerebral ischemia, and thus help neutralize a major source of morbidity and mortality in this disease process. ..
  20. Molecular Imaging to Determine the Risk of Rupture of Cerebral Aneurysms
    Alexei Bogdanov; Fiscal Year: 2009
    ..Current case fatality rate for aneurysmal subarachnoid hemorrhage is 50%, and though a trend toward gradual improvement is evident, the fatality rate is high and the ..
  21. Neurovascular Protection for Subarachnoid Hemorrhage
    John H Zhang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Subarachnoid hemorrhage (SAH) is a devastating disease carrying with it a mortality of 50% within the first 30 days (30% of patients die from the impact of the initial bleeding, 10% die from re-..
  22. The role of neutrophils in SAH
    JOSE JAVIER PROVENCIO; Fiscal Year: 2011
    b>Subarachnoid hemorrhage is the third leading cause of stroke in the United States but accounts for fifty percent of the mortality and morbidity in cerebral vascular events...
  23. Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling and Inflammation
    Tomoki Hashimoto; Fiscal Year: 2013
    ..Incidence of intracranial aneurysms and subarachnoid hemorrhage are higher in women than in men...
  24. Toward Individually-tailored Medicine: Probabilistic Models of Cerebral Aneurysms
    Fernando Vinuela; Fiscal Year: 2012
    ..The associated mortality rate and comorbidity resultant from ruptured ICAs are extreme: subarachnoid hemorrhage causes 50% of individuals to die within one month of rupture, and more than one third of survivors ..
  25. The Effects of Antiepileptic Drugs on Serologic Indices of Vascular Risk
    Scott Mintzer; Fiscal Year: 2012
    ..Aim 1: We will test the hypothesis that patients with acute subarachnoid hemorrhage randomized to phenytoin (PHT) will experience significant increases in serum CRP and atherogenic lipids, ..
  26. Microglial Signal Transduction in Fever and Vasospasm after Subarachnoid Hemorrha
    Khalid A Hanafy; Fiscal Year: 2013
    ..of microglia and inflammatory signal transduction pathways in the production of fever and vasospasm after subarachnoid hemorrhage. Thirty thousand Americans have aneurysmal subarachnoid hemorrhage (aSAH) each year...
  27. Improving Clinical Outcomes Following Subarachnoid Hemmorhage Using CT Perfusion
    PINA CHRISTINE SANELLI; Fiscal Year: 2012
    ..is not well understood leading to indeterminate diagnosis and delayed treatment following aneurysmal subarachnoid hemorrhage (A-SAH)...
  28. EP2 Allosteric Potentiators for Subarachnoid Hemorrhage
    Raymond J Dingledine; Fiscal Year: 2012
    ..Patients experiencing a subarachnoid hemorrhage are at substantial risk of experiencing a stroke-like ischemic event 4-14 days after their surgery to ..
  29. eNOS polymorphisms and cerebral vasospasm after SAH
    Nerissa U Ko; Fiscal Year: 2010
    ..Cerebral vasospasm is a common complication of aneurysmal subarachnoid hemorrhage (SAH) and remains a major cause of death and disability after aneurysm rupture...
  30. exRNA signatures Predict Outcomes after brain injury
    Robert Spetzler; Fiscal Year: 2013
    ..Hemorrhagic infarcts (such as aneurysmal subarachnoid hemorrhage and intraventricular hemorrhage) are rare but devastating complications of arterial rupture...
  31. Calcium signaling in the cerebrovascular unit in health and disease
    Mark T Nelson; Fiscal Year: 2013
    ..tone and neurovascular coupling (NVC) normally, and following ischemia/reperfusion (l/R) injury and subarachnoid hemorrhage (SAH)...
  32. Washington University SPOTRIAS Center
    COLIN PIETER DERDEYN; Fiscal Year: 2012
    ..referral center for acute cerebrovascular disease and treat nearly 150 patients per year with aneurysmal subarachnoid hemorrhage. Finally, we have a large number of experienced, NIH-funded investigators dedicated to basic, ..
  33. Gentamicin for Improving Survival and Outcome after Subarachnoid Hemorrhage.
    Joshua B Bederson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aneurysmal subarachnoid hemorrhage is a medical emergency associated with high early mortality and morbidity...
  34. Biochemical Markers in Adult Patients with Aneurysmal Subarachnoid Hemorrhage
    Stephen B Lewis; Fiscal Year: 2010
    ..Aneurysmal subarachnoid hemorrhage (ASAH) is a serious event in which brain injury is inflicted...
  35. Epigenomics of Patient Outcomes after Aneurysmal SAH
    Yvette Conley; Fiscal Year: 2013
    ..by applicant): This application focuses on understanding the pathophysiology following aneurysmal subarachnoid hemorrhage (aSAH)...
  36. Pre-clinical Development of a Context-Dependent NMADR Neuroprotectant for Treatme
    SCOTT JAMES MYERS; Fiscal Year: 2013
    ..context-dependent, pH-sensitive, NR2B subunit selective NMDA receptor antagonist for prophylactic use in subarachnoid hemorrhage (SAH)...
  37. Protective Role of Interleukin 10 in Neuroborreliosis
    Diego Cadavid; Fiscal Year: 2009
    ..and more severe microvascular injury in the brain and other organs and early death from intracerebral/subarachnoid hemorrhage. These results support a fundamental protective role for IL-10 in RF borreliosis...
  38. HYPOTHERMIA DURING INTRACRANIAL ANEURYSM SURGERY
    Michael Todd; Fiscal Year: 2003
    Aneurysmal subarachnoid hemorrhage (SAH) remains a major cause of morbidity and mortality. Since the incidence peaks in mid-life, and since many survivors are permanently damaged, the human and economic costs are immense...
  39. Constrictor / Mitogen Induced Remodeling of Cerebral Arterioles
    JAY HUMPHREY; Fiscal Year: 2009
    Cerebral vasospasm occurs in up to 50% of patients presenting with a subarachnoid hemorrhage (SAH), the most common cause of which is a ruptured intracranial aneurysm...
  40. Doppler flow wires and hemodynamics in intracranial aneurysms
    LOUIS JOONG KIM; Fiscal Year: 2013
    ..provided by applicant): Intracranial aneurysms carry a risk of rupture with potentially life-threatening subarachnoid hemorrhage. Study of the hemodynamic properties of cerebral vasculature in patients with ruptured and unruptured ..
  41. NEUROGENIC INFLUENCES ON LUNG FLUID AND SOLUTE EXCHANGE
    Fred Minnear; Fiscal Year: 1990
    ..as mechanisms in the development of pulmonary edema after a variety of clinical syndromes such as subarachnoid hemorrhage, intracranial hypertension, cerebral seizures, catecholamine overload, and exposure to high altitudes...
  42. Determining Genetic and Biomarker Predictors of DCI and Long Term Outcomes after
    Paula R Sherwood; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Data from the proposed study, currently unexplored in persons with aneurysmal subarachnoid hemorrhage, will impact public health by serving as the basis for both therapeutic interventions designed to ..
  43. MULTIPHOTON LASER SCANNING MICROSCOPE
    VICTOR LOUIS FRIEDRICH; Fiscal Year: 2010
    ..study atherosclerotic plaques, HIV-associated nephropathy, tumor metastasis, tendon damage and repair, subarachnoid hemorrhage, vestibular sensory organs, immune system dynamics, and renal epithelial cell function...
  44. Traumatic Brain Injury Clinical Trials Network
    Ramon Diaz-Arrastia; Fiscal Year: 2012
    ..He has experience in multicenter collaborative trials in TBI, subarachnoid hemorrhage, and spinal cord injury...
  45. Hemodynamics in Intracranial Aneurysm Pathogenesis
    DANIEL MARCELO SFORZA; Fiscal Year: 2012
    ..Because cerebral aneurysms are being more frequently diagnosed before they rupture and the prognosis of subarachnoid hemorrhage is still poor, treating clinicians are often required to judge which aneurysms are prone to progression ..
  46. STRESS GENES AND HEMORRHAGIC BRAIN INJURY
    Frank Sharp; Fiscal Year: 2001
    b>Subarachnoid hemorrhage and intracerebral hemorrhage are important causes of stroke...
  47. Cerebral artery Ca2+ signaling & subarachnoid hemorrhage
    George Wellman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cerebral vasospasm following aneurysm rupture and subarachnoid hemorrhage (SAH) is a devastating disorder that inflicts disability and death upon thousands of individuals each year...
  48. Ethyl Nitrite and Subarachnoid Hemorrhage
    Huaxin Sheng; Fiscal Year: 2009
    Cerebral vasospasm develops following subarachnoid hemorrhage (SAH), especially in patients with aneurysm rupture and causes major neurological and cognitive deficits and death...
  49. Defining targets for the treatment of delayed cerebral vasospasm after SAH
    JOSE JAVIER PROVENCIO; Fiscal Year: 2013
    ..to investigate the role of neutrophils in the development of delayed neurologic deterioration (DND) after subarachnoid hemorrhage (SAH)...
  50. MECHANISM AND THERAPY OF CEREBROVASCULAR SPASM
    Thomas Duff; Fiscal Year: 1992
    Cerebral vasospasm (CVS) is a life-threatening sequela for those who suffer subarachnoid hemorrhage (SAH)...
  51. Morehouse School of Medicine SNRP
    Peter R MacLeish; Fiscal Year: 2013
    ..iii) The effectiveness of a combination therapy against delayed neuronal deterioration after subarachnoid hemorrhage (Project 3, PI Namura)...
  52. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2005
    We are investigating cerebral vasospasm which is an important cause of cerebral ischemia after subarachnoid hemorrhage (SAH)...
  53. ACUTE BRAIN INJURY AFTER SUBARACHNOID HEMORRHAGE
    Joshua Bederson; Fiscal Year: 2001
    ..of the most important of these is the lack of treatment options for patients who have suffered a severe subarachnoid hemorrhage (SAH)...
  54. MAPPING INTRACRANIAL ANEURYSM SUSCEPTIBILITY LOCI
    Lisa Cannon Albright; Fiscal Year: 2001
    ..S. suffer from subarachnoid hemorrhage due to a ruptured cerebral aneurysm, with nearly 60% fatality...
  55. THE OPTIMAL MANAGEMENT OF CEREBRAL ANEURYSMS
    Joseph King; Fiscal Year: 2004
    ..Each year 21,000 of these individuals suffer a subarachnoid hemorrhage, resulting in significant morbidity, mortality, and expense...
  56. Magnesium as a Neuroprotective Agent for Pediatric TBI
    DONALD SHAFFNER; Fiscal Year: 2002
    ..Magnesium has a good safety profile and is being tested in pilot studies of adults with stroke and subarachnoid hemorrhage for its neuroprotective potential...
  57. Cerebral Microvascular Endothelin Production
    Momoh Yakubu; Fiscal Year: 2003
    ..Despite progress in the diagnosis of subarachnoid hemorrhage (SAH), SAH-induced cerebral vasospasm remains one of treatable causes of morbidity and mortality in ..
  58. CEREBAL ARTERIAL ADVENTITIA AND VASOSPASM
    ZVONIMIR KATUSIC; Fiscal Year: 2001
    Chronic cerebral vasospasm is a major cause of morbidity and mortality in patients with subarachnoid hemorrhage. Pathogenesis of vasospasm is not completely understood, but existing evidence suggests that impairment of nitric oxide ..
  59. RANDOMIZED STUDY OF NICARDIPINE IN SAH
    Neal Kassell; Fiscal Year: 1992
    Approximately 28,000 individuals in North America have a subarachnoid hemorrhage from a ruptured intracranial aneurysm each year...
  60. HEAT SHOCK PROTEINS AND VASOSPASM
    Colleen Brophy; Fiscal Year: 2005
    ..surgery, non-occlusive mesenteric ischemia' Raynaud's syndrome, and cerebral ischemia after subarachnoid hemorrhage. Our understanding of the pathophysiology of vasospasm is limited, largely due to a lack of good models...
  61. Neurorestorative Strategy for Chemotherapy-induced Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2009
    ..animal models of a variety of neurological disorders such as traumatic brain injury, spinal cord injury, subarachnoid hemorrhage and multiple sclerosis, implicating a therapeutic efficacy for these diseases...
  62. PATHOPHYSIOLOGY OF BLOOD INDUCED CEREBRAL ARTERIOPATHY
    Marc Mayberg; Fiscal Year: 1991
    Despite extensive research over 25 years, the basic pathophysiology of cerebral vasospasm after subarachnoid hemorrhage (SAH) is unknown, due in part to limitations of current experimental models...
  63. ENDOTHELIN AND OXIDANT STRESS IN CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 1999
    Cerebral vasospasm is delayed onset of vasoconstriction occurring days after aneurysmal subarachnoid hemorrhage. It is a major cause of stroke and death after subarachnoid hemorrhage...
  64. Mechanisms Regulating Cerebral Blood Flow
    David Harder; Fiscal Year: 2009
    ..acids control nutritive cerebral blood flow (CBF) under normal and pathologic conditions (inflammation, subarachnoid hemorrhage (SAH) and reactive hyperemia)...
  65. A Novel Neuroprotective Approach for Ischemia
    Zhi Gang Jiang; Fiscal Year: 2004
    ..Global ischemia occurs in various conditions, including intracerebral hemorrhage due to hypertension and subarachnoid hemorrhage, and associates with cardiac arrest hypotension, closed head injury, drowning, strangulation, and open-..