intracranial thrombosis

Summary

Summary: Formation of a clot composed of platelets and fibrin within the lumen of an intracranial artery or vein, which may result in CEREBRAL INFARCTION. Arterial thrombosis is associated with INTRACRANIAL ARTERIOSCLEROSIS, but may also result from hypercoagulability states (see THROMBOPHILIA). Cerebral vein thrombosis is frequently complicated by INTRACRANIAL HEMORRHAGES.

Articles from Journal RESEARCH

Top Publications

  1. ncbi Disturbance of perineuronal nets in the perilesional area after photothrombosis is not associated with neuronal death
    Magdalena Karetko-Sysa
    Department of Molecular and Cellular Neurobiology, The Nencki Institute of Experimental Biology, Warsaw, Poland
    Exp Neurol 231:113-26. 2011
  2. ncbi Photochemically induced cerebral ischemia in a mouse model
    Jung Kil Lee
    Department of Neurosurgery, Chonnam National University Hospital, Gwangju 501 757, South Korea
    Surg Neurol 67:620-5; discussion 625. 2007
  3. ncbi Cerebral venous thrombosis: diagnosis and management
    M G Bousser
    Hôpital Lariboisière Service de Neurologie, Paris, France
    J Neurol 247:252-8. 2000
  4. ncbi Visualization of stroke with clinical MR imagers in rats: a feasibility study
    Feng Chen
    Department of Radiology, University Hospitals, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 233:905-11. 2004
  5. ncbi Dynamic changes of magnetic resonance imaging abnormalities in relation to inflammation and glial responses after photothrombotic cerebral infarction in the rat brain
    M Schroeter
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Acta Neuropathol 101:114-22. 2001
  6. pmc Headache as the only neurological sign of cerebral venous thrombosis: a series of 17 cases
    R Cumurciuc
    Department of Neurology, Lariboisiere Hospital, 2 rue Ambroise Pare, 75010 Paris, France
    J Neurol Neurosurg Psychiatry 76:1084-7. 2005
  7. ncbi Non-invasive induction of focal cerebral ischemia in mice by photothrombosis of cortical microvessels: characterization of inflammatory responses
    Michael Schroeter
    Department of Neurology, Heinrich Heine Universitaet, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    J Neurosci Methods 117:43-9. 2002
  8. ncbi Hardware and methodology for targeting single brain arterioles for photothrombotic stroke on an upright microscope
    Albrecht Sigler
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, 2255 Wesbrook Mall, University of British Columbia, Vancouver, BC, Canada
    J Neurosci Methods 170:35-44. 2008
  9. ncbi Should decompressive surgery be performed in malignant cerebral venous thrombosis?: a series of 12 patients
    Marie Théaudin
    AP HP, Hopital Bicetre, Service de Neurologie, Le Kremlin Bicetre, France
    Stroke 41:727-31. 2010
  10. ncbi Natural history of cerebral vein thrombosis: a systematic review
    Francesco Dentali
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 108:1129-34. 2006

Detail Information

Articles from Journal RESEARCH1

Publications218 found, 100 shown here

  1. ncbi Disturbance of perineuronal nets in the perilesional area after photothrombosis is not associated with neuronal death
    Magdalena Karetko-Sysa
    Department of Molecular and Cellular Neurobiology, The Nencki Institute of Experimental Biology, Warsaw, Poland
    Exp Neurol 231:113-26. 2011
    ..Our results suggest that the PNN reduction was not a result of cellular death and could be considered an attempt to create conditions favorable for synaptic remodeling...
  2. ncbi Photochemically induced cerebral ischemia in a mouse model
    Jung Kil Lee
    Department of Neurosurgery, Chonnam National University Hospital, Gwangju 501 757, South Korea
    Surg Neurol 67:620-5; discussion 625. 2007
    ..MCAO has been widely used to produce ischemic brain lesions. The lesions induced by MCAO tend to be variable in size because of the variance in the collateral blood supply found in the mouse brain...
  3. ncbi Cerebral venous thrombosis: diagnosis and management
    M G Bousser
    Hôpital Lariboisière Service de Neurologie, Paris, France
    J Neurol 247:252-8. 2000
    ..Diagnosis and treatment of CVT should be considered as an emergency because of the considerable potential for full recovery in this condition...
  4. ncbi Visualization of stroke with clinical MR imagers in rats: a feasibility study
    Feng Chen
    Department of Radiology, University Hospitals, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 233:905-11. 2004
    ..05). There was no difference in lesion size at perfusion-weighted MR imaging between superacute and subacute phases (P > .05). Performance of certain stroke-related research in rats is feasible with clinical MR imagers...
  5. ncbi Dynamic changes of magnetic resonance imaging abnormalities in relation to inflammation and glial responses after photothrombotic cerebral infarction in the rat brain
    M Schroeter
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Acta Neuropathol 101:114-22. 2001
    ..Heterogeneous ADC together with T2 elevation reflected a late infarct stage (14 days) when pseudocystic degeneration and scar formation had occurred...
  6. pmc Headache as the only neurological sign of cerebral venous thrombosis: a series of 17 cases
    R Cumurciuc
    Department of Neurology, Lariboisiere Hospital, 2 rue Ambroise Pare, 75010 Paris, France
    J Neurol Neurosurg Psychiatry 76:1084-7. 2005
    ..Headache is the most frequent symptom in cerebral venous thrombosis (CVT), and usually the first. However, it has rarely been reported as the only symptom of CVT...
  7. ncbi Non-invasive induction of focal cerebral ischemia in mice by photothrombosis of cortical microvessels: characterization of inflammatory responses
    Michael Schroeter
    Department of Neurology, Heinrich Heine Universitaet, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    J Neurosci Methods 117:43-9. 2002
    ..It may provide a useful model to study functional aspects of lesion-associated and remote molecular responses in transgenic mice...
  8. ncbi Hardware and methodology for targeting single brain arterioles for photothrombotic stroke on an upright microscope
    Albrecht Sigler
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, 2255 Wesbrook Mall, University of British Columbia, Vancouver, BC, Canada
    J Neurosci Methods 170:35-44. 2008
    ..It is conceivable that this modification and laser system can also be used for other scenarios where targeted photoactivation or photobleaching would be required...
  9. ncbi Should decompressive surgery be performed in malignant cerebral venous thrombosis?: a series of 12 patients
    Marie Théaudin
    AP HP, Hopital Bicetre, Service de Neurologie, Le Kremlin Bicetre, France
    Stroke 41:727-31. 2010
    ..In malignant cerebral venous thrombosis (CVT) patients, emergency decompressive surgery has been suggested as a life-saving procedure. We report 12 patients with malignant CVT, among whom 8 underwent operation...
  10. ncbi Natural history of cerebral vein thrombosis: a systematic review
    Francesco Dentali
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Blood 108:1129-34. 2006
    ..8% (range, 0%-11.7%) had objectively confirmed recurrence. We conclude that patients with CVT have a low risk of death and that most patients have a good long-term prognosis...
  11. ncbi Causes and predictors of death in cerebral venous thrombosis
    Patrícia Canhão
    Department of Neurosciences and Mental Health, Hospital Santa Maria, 1649 035 Lisbon, Portugal
    Stroke 36:1720-5. 2005
    ..We aimed to analyze the causes and predictors of death during the acute phase of CVT in the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) to identify preventable or treatable causes...
  12. ncbi Cerebral venous thrombosis: an update
    Marie Germaine Bousser
    AP HP Hôpital Lariboisière Service de Neurologie, Paris, France
    Lancet Neurol 6:162-70. 2007
    ..Heparin is the first-line treatment, but in a few cases more aggressive treatments, such as local intravenous thrombolysis, mechanical thrombectomy, and decompressive hemicraniectomy, may be required...
  13. ncbi Cerebral venous thrombosis in children
    K S Carvalho
    Division of Pediatric Neurology, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, USA
    J Child Neurol 16:574-80. 2001
    ..Two had other deficits. Neonatal cerebral venous thrombosis is probably more common than previously thought, and outcomes are worse in this group. All children with cerebral venous thrombosis should be tested for coagulation disorders...
  14. ncbi Cerebral venous and sinus thrombosis: incidence and causes
    Jan Stam
    Department of Neurology, University of Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands
    Adv Neurol 92:225-32. 2003
  15. ncbi Diagnostic pitfalls in paediatric ischaemic stroke
    Kees P J Braun
    Department of Child Neurology, University Medical Centre Utrecht, The Netherlands
    Dev Med Child Neurol 48:985-90. 2006
    ..We recommend that children with stroke be evaluated in a centre with expertize, using standardized diagnostic protocols and careful follow-up...
  16. ncbi Do normal D-dimer levels reliably exclude cerebral sinus thrombosis?
    Christoph M Kosinski
    Department of Neurology, Universitatsklinikum Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Stroke 35:2820-5. 2004
    ..Because measurement of D-dimers has been demonstrated to be helpful in excluding thromboembolic disease, our aim was to investigate whether D-dimers would be also sensitive enough to exclude CST...
  17. ncbi Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment
    Guido Stoll
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Blood 112:3555-62. 2008
    ..This review discusses recent advances related to antithrombotic strategies in experimental stroke research...
  18. ncbi Utility of D-dimer in the diagnosis of cerebral venous sinus thrombosis
    B Cucchiara
    J Thromb Haemost 3:387-9. 2005
  19. ncbi In vivo detection of developing vessel occlusion in photothrombotic ischemic brain lesions in the rat by iron particle enhanced MRI
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    J Cereb Blood Flow Metab 25:1548-55. 2005
    ..This new imaging technique may aid to evaluate antithrombotic treatment strategies in the future...
  20. ncbi Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions
    Jukka Jolkkonen
    Department of Neurology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Neurosci Lett 428:99-102. 2007
    ..The results suggest that bleeding around cortical infarct is part of the wound healing process and may not impair functional outcome...
  21. ncbi Cerebral venous thrombosis 3-year clinical outcome in 55 consecutive patients
    G Breteau
    Dept of Neurology, Lens Hospital, Lens, France
    J Neurol 250:29-35. 2003
    ..However, 3/4 of survivors have residual symptoms. Therefore, despite a low mortality rate, CVT remains a serious disorder...
  22. ncbi Cerebral venous thrombosis in children: a multifactorial origin
    Christine Heller
    Department of Pediatrics Pediatric Hematology and Oncology, University of Frankfurt am Main, Germany
    Circulation 108:1362-7. 2003
    ....
  23. ncbi Carboxypeptidase U (TAFIa) decreases the efficacy of thrombolytic therapy in ischemic stroke patients
    Raf Brouns
    Department of Neurology and Memory Clinic, ZNA Middelheim Hospital, Antwerp, Belgium
    Clin Neurol Neurosurg 111:165-70. 2009
    ..In vitro and in vivo data suggest that activation of procarboxypeptidase U (proCPU) inhibits fibrinolysis...
  24. ncbi Apoptotic cell death progression after photothrombotic focal cerebral ischaemia: effects of the lipophilic iron chelator 2,2'-dipyridyl
    Michael van Hoecke
    Laboratoire de Pharmacodynamie et Physiologie Pharmaceutique L3P, Faculte de Pharmacie, BP 87900, 21079 Dijon Cedex, France
    Eur J Neurosci 22:1045-56. 2005
    ..Furthermore, a large decrease of apoptotic bodies was associated with a significant drop of caspase and PARP-1 cleavages, suggesting that the protective effect of DP closely correlates with limitation of apoptosis expansion...
  25. ncbi A negative D-dimer assay does not rule out cerebral venous thrombosis: a series of seventy-three patients
    Isabelle Crassard
    Neurology Department, Lariboisiere Hospital, 2 rue Ambroise Pare, 75010 Paris, France
    Stroke 36:1716-9. 2005
    ..Previous reports have emphasized the potential clinical utility of D-dimer assay in CVT diagnosis...
  26. ncbi Cerebral thrombosis in childhood nephrosis
    Arun Gangakhedkar
    Kidz First Community Health, Otahuhu, New Zealand
    J Paediatr Child Health 41:221-4. 2005
    ..We describe this case and review available literature to highlight the importance of suspecting and recognizing this potentially life threatening complication and initiating early treatment...
  27. ncbi Diffusion-weighted mr in cerebral venous thrombosis
    K O Lovblad
    Department of Neuroradiology, Inselspital, University of Bern, Switzerland
    Cerebrovasc Dis 11:169-76. 2001
    ..It can also demonstrate early ischemic changes, and can differentiate conventional T2-weighted MR areas of cytotoxic from vasogenic edema...
  28. ncbi Clinical picture of patients with cerebral venous thrombosis and patterns of dural sinus involvement
    Mauro Bergui
    Department of Neuroradiology, University of Turin, Ospedale S Giovanni Battista, Turin, Italy
    Cerebrovasc Dis 16:211-6. 2003
    ..Cerebral venous thrombosis may cause focal brain lesions or an isolated intracranial hypertension without focal signs. We investigated whether these different clinical pictures correspond to different patterns of dural sinus thrombosis...
  29. ncbi Cerebral venous thrombosis, intraventricular haemorrhage and white matter lesions in a preterm newborn with factor V (Leiden) mutation
    L A Ramenghi
    Paediatric Department, University of Leeds, General Infirmary at Leeds, UK
    Neuropediatrics 33:97-9. 2002
    ..The baby was later found to be heterozygous for factor V Leiden...
  30. ncbi Long-term prognosis of cerebral vein and dural sinus thrombosis. results of the VENOPORT study
    J M Ferro
    Department of Neurology, Hospital de Santa Maria, Lisboa, Portugal
    Cerebrovasc Dis 13:272-8. 2002
    ..The long-term functional prognosis of patients with CVDST was fairly good with complete recovery in the majority of cases. However, these patients had a moderate risk of further thrombotic events and seizures...
  31. ncbi Isolated lateral sinus thrombosis: a series of 62 patients
    Mariem Damak
    Neurology Department, Lariboisiere Hospital, Paris, France
    Stroke 40:476-81. 2009
    ..Little attention has been recently paid to this variety of thrombosis. We therefore reviewed all cases of isolated lateral sinus thrombosis prospectively collected in our center (1997 to 2006)...
  32. ncbi Cerebral vein and dural sinus thrombosis in elderly patients
    Jose M Ferro
    Department of Neurosciences and Mental Health, Hospital Santa Maria, 1649 035 Lisbon, Portugal
    Stroke 36:1927-32. 2005
    ..The clinical features and prognosis of cerebral vein and dural sinus thrombosis (CVT) in elderly patients have not been previously described...
  33. ncbi Early seizures in cerebral vein and dural sinus thrombosis: risk factors and role of antiepileptics
    Jose M Ferro
    Department of Neurosciences and Mental Health, Hospital Santa Maria, Lisboa, Portugal
    Stroke 39:1152-8. 2008
    ..The risk of seizure early after the diagnosis of cerebral vein and dural sinus thrombosis (CVT) is not known, and the use of prophylactic antiepileptic (AED) medication in the acute phase of CVT is controversial...
  34. ncbi Obstetric cerebral venous thrombosis
    Bhojo A Khealani
    Neurology Section, Department of Medicine, The Aga Khan University, Karachi
    J Pak Med Assoc 56:490-3. 2006
    ..During puerperium additional risk factors include infection and instrumental delivery or Caesarean section. The management follows general rules as for the venous thrombosis unrelated to pregnancy, however the prognosis is different...
  35. ncbi Angiographic analysis of intravascular thrombus volume in patients with acute ischemic stroke
    Adnan I Qureshi
    Imaging Core Laboratory, Zeenat Qureshi Stroke Research Center, Department of Neurology and Neurosciences, University of Medicine and Dentistry of New Jersey, Newark, USA
    J Endovasc Ther 14:475-82. 2007
    ..To investigate the role that intravascular thrombus volume plays in mechanical thrombectomy and dose-titrated algorithms using pharmaceutical thrombolytic therapies...
  36. ncbi Delayed cerebral venous thrombosis in a patient with spontaneous intracranial hypotension
    M Y Lan
    Departments of Neurology, Chang Gung Memorial Hospital Kaohsiung Medical Centre, Chang Gung University College of Medicine, Kaohsiung County 833, Taiwan
    Cephalalgia 27:1176-8. 2007
  37. ncbi Neurological complications of paroxysmal nocturnal hemoglobinuria
    N Jewel Samadder
    Can J Neurol Sci 34:368-71. 2007
  38. ncbi Cerebral cortical and deep venous thrombosis without sinus thrombosis: clinical MRI correlates
    A Sagduyu
    Stroke Unit, Department of Neurology, Ege University School of Medicine, Izmir, Turkey
    Acta Neurol Scand 114:254-60. 2006
    ..Our aim is to determine the relationship between magnetic resonance imaging (MRI) findings and clinical findings in patients with CDVT...
  39. ncbi Neuroimaging of cerebral venous thrombosis
    Mohammad Wasay
    Department of Neurology, The Aga Khan University, Karachi, Pakistan
    J Neuroimaging 15:118-28. 2005
    ..Contrast angiography should be strongly considered if isolated cortical vein thrombosis is suspected...
  40. ncbi Ictal monoparesis associated with lesions in the primary somatosensory area
    R Matsumoto
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Neurology 65:1476-8. 2005
    ..In the presence of an SI lesion, the epileptic activity at the sensorimotor area could lead to selective or predominant activation of the inhibitory motor system...
  41. ncbi [Isolated cortical vein thrombosis. Clinical and neuroradiological aspects]
    W Muller-Forell
    Institut für Neuroradiologie, Klinikum der Johannes Gutenberg Universitat, 55101Mainz
    Radiologe 47:255-61. 2007
    ..We report on five patients with this diagnosis, who all presented with focal sensomotoric seizures. Imaging with CT and MRI was the leading method. All patients were treated with oral anticoagulation and showed full recovery...
  42. ncbi Interventional neuroradiology in the treatment of cerebral venous thrombosis
    Valeria Caso
    Stroke Unit and Division of Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Via Dottori, Sant Andrea delle Fratte, Perugia, Italy
    Front Neurol Neurosci 23:144-60. 2008
    ..There is no reason to recommend interventional radiology in these patients who are likely to have a good outcome unless proven superior in a trial...
  43. ncbi Resolution of bilateral thalamic lesions due to deep cerebral venous thrombosis
    Daniel C Bezerra
    Department of Neurology, Lausanne, Switzerland
    Arch Neurol 62:1638-9. 2005
  44. ncbi [Current controversies in the diagnosis and management of cerebral venous and dural sinus thrombosis]
    S Schwarz
    Neurologische Universitatsklinik, Klinikum Mannheim, Mannheim
    Nervenarzt 74:639-53. 2003
    ..Both methods have a high sensitivity for cerebral venous thrombosis. Local fibrinolytic therapy or other aggressive recanalizing methods can not be generally recommended...
  45. ncbi [Isolated cortical vein thrombosis: report of two cases]
    Héctor Miranda V
    Intermedio Neurológico, Departamento de Neurologia, Hospital Clinico, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 135:1313-7. 2007
    ..Neuroimages show ischemic abnormalities that do not follow an arterial vascular territory, often with an early hemorrhagic component. There is a good clinical response to heparin...
  46. ncbi Cerebral venous thrombosis: analysis of a multicenter cohort from the United States
    Mohammad Wasay
    Aga Khan University, Karachi, Pakistan
    J Stroke Cerebrovasc Dis 17:49-54. 2008
    ..The data regarding diagnosis, prognosis, management, and outcome of patients with cerebral venous thrombosis are limited from the United States...
  47. ncbi Intracranial bilateral vertebral artery dissection during anticoagulation after cerebral venous and sinus thrombosis (CSVT)
    B Turowski
    Department of Neuroradiology, Institute of Diagnostic Radiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Acta Neurochir (Wien) 149:793-7; discussion 797. 2007
    ..Endovascular occlusion of the pathological segment of the right vertebral artery including the dissecting aneurysm and conservative management of the other side resulted in complete recovery without neurological complications...
  48. ncbi Haematologic disorders and cerebral venous thrombosis
    Naveed Akhtar
    Hamad Medical Corporation, Doha, Qatar
    J Pak Med Assoc 56:498-501. 2006
    ..If a hereditary hypercoagulable state is found, it also may be appropriate to recommend screening of other family members...
  49. ncbi Unusual causes of cerebral venous thrombosis
    Ismail A Khatri
    Department of Neurology, Dow University of Health Sciences and Civil Hospital, Karachi
    J Pak Med Assoc 56:501-6. 2006
    ..In this review, we have focused on relatively rare and unusual causes of cerebral venous thrombosis. Many of the conditions described have very few reported cases and the causal relationship is not well established...
  50. ncbi Pathophysiology of cerebral venous thrombosis--an overview
    Ahmed Itrat
    Department of Neurology, The Aga Khan University, Karachi
    J Pak Med Assoc 56:506-8. 2006
    ..Pathophysiology of CVST is diverse and makes it easier to understand the diversity of clinical presentations...
  51. ncbi Mechanism of neuronal injury in cerebral venous thrombosis
    Uzma Usman
    Department of Neurology, The Aga Khan University, Karachi
    J Pak Med Assoc 56:509-12. 2006
    ....
  52. ncbi Cerebral venous thrombosis--clinical presentations
    Man Mohan Mehndiratta
    Department of Neurology, G B Pant Hospital, New Delhi 110002, India
    J Pak Med Assoc 56:513-6. 2006
    ..5 years. Of the 4 females two were postpartum; one was on oral contraceptive and in one Antiphospholipid antibodies (APLA) were positive. Amongst two males one had hyperhomocysteinemia and one had hyperlipidemia...
  53. ncbi Cerebral venous system anatomy
    Muhammad Azeem Uddin
    Department of Radiology, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 56:516-9. 2006
    ..With the exception of wide variations of basal vein, the deep system is rather constant compared to the superficial venous system. Hence their thrombosis is easy to recognize...
  54. ncbi Computed tomographic imaging of cerebral venous thrombosis
    Mohammad Kamran Kamal
    Department of Radiology, The Aga Khan University Hospital, Karachi
    J Pak Med Assoc 56:519-22. 2006
    ..A brief discussion of CT venography, which has come around as a promising tool for diagnosing CVT as a result of newer innovations in CT technology, is also included here...
  55. ncbi MRI and MRV in cerebral venous thrombosis
    Zafar Sajjad
    Department of Radiology, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 56:523-6. 2006
    ..Appearances of these lesions too are dependent on their age. Diffuse changes of raised intracranial pressure with gyral effacement may also be present...
  56. ncbi Cerebral angiography and venography for evaluation of cerebral venous thrombosis
    Nazli Janjua
    University of Medicine and Dentistry of New Jersey, Newark, NJ 07113, USA
    J Pak Med Assoc 56:527-30. 2006
    ..Knowledge of the normal drainage patterns of the cerebral venous system is essential in interpreting angiographic information obtained in the evaluation of patients with suspected cerebral venous thrombosis...
  57. ncbi Heparin in the treatment of cerebral venous thrombosis
    Saad Shafqat
    Department of Medicine Neurology, Aga Khan University Medical College, Karachi
    J Pak Med Assoc 56:541-3. 2006
    ..Newer antithrombotic agents such as ximelagatran may offer advantages over heparin and need to be investigated in the treatment of CVT...
  58. ncbi Complications associated with cerebral venous thrombosis
    Fazeel Mukhtar Siddiqui
    Department of Medicine, The Aga Khan University Hospital, Karachi
    J Pak Med Assoc 56:547-51. 2006
    ..g. pulmonary embolism. The chronic complications are rare but are potentially treatable, e.g. dural AVFistula nidus obliteration with intervention...
  59. ncbi Developmental venous anomaly with an arteriovenous shunt and a thrombotic complication. Case report
    S Agazzi
    Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Neurosurg 94:533-7. 2001
    ..Although no treatment can be offered, the presence of an AV shunt in a DVA warrants close follow-up observation because such lesions may represent a particular subtype of AVM and, therefore, may exhibit an aggressive clinical behavior...
  60. ncbi Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke
    Vasantha Padma
    All India Institute of Medical Science, Dehli, India
    Expert Rev Cardiovasc Ther 4:405-15. 2006
    ..High-quality, randomized trials that adequately study heparin use in patients using modern technology for vascular lesions and stroke subtypes are lacking, and need to be performed...
  61. ncbi [Cerebral venous thrombosis--diagnosis and treatment]
    Hans Jørgen Johnsen
    Avdeling for nevrologi og klinisk nevrofysiologi, St Olavs Hospital, Olav Kyrres gate 17, 7006 Trondheim
    Tidsskr Nor Laegeforen 127:1069-73. 2007
    ..This review article concerns the aetiology, pathology, diagnostic work-up and treatment of the condition...
  62. ncbi Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited. Results of a prospective study
    Erwin Stolz
    Dept of Neurology, Justus Liebig University, Am Steg 14, 35385 Giessen, Germany
    J Neurol 254:729-34. 2007
    ..Several case reports have linked iron deficiency anemia with the occurrence of cerebral venous thrombosis (CVT) or stroke, yet, it is unclear whether this is a chance association...
  63. ncbi Cerebral veins and sinuses
    Erwin Stolz
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Front Neurol Neurosci 21:182-93. 2006
    ..It was not until the mid-1990s that venous transcranial ultrasound in adults was systematically developed. In the following the examination technique and clinical applications of this technique are summarized...
  64. ncbi Spontaneous thrombosis of cerebral aneurysms presenting with ischemic stroke
    Jose E Cohen
    Department of Neurosurgery, Hadassah Hebrew University Hospital, Jerusalem, Israel Department of Radiology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    J Neurol Sci 254:95-8. 2007
    ..We present documented cases of this unusual entity and review the literature...
  65. ncbi Deep cerebral vein thrombosis associated with iron deficiency anaemia in adults
    Kemal Balci
    Department of Neurology, Faculty of Medicine, University of Trakya, Edirne 22030, Turkey
    J Clin Neurosci 14:181-4. 2007
    ..Both of our patients had severe hypochromic microcytic anaemia due to iron deficiency, and both had a good prognosis after 2 months...
  66. ncbi Cerebral venous thrombosis: recent advances and need for an Asian registry
    Mohammad Wasay
    J Pak Med Assoc 56:483-4. 2006
  67. ncbi Incidence and epidemiology of cerebral venous thrombosis
    Fazeel Mukhtar Siddiqui
    The Aga Khan University Hospital, Karachi
    J Pak Med Assoc 56:485-7. 2006
    ..The newer epidemiologic data derived from a Caucasian database; suggest a better overall prognosis, younger age at distribution than arterial stroke...
  68. ncbi Paediatric cerebral venous thrombosis
    Alper I Dai
    Department of Pediatrics, Shcool of Medicine, Gaziantep University, Gaziantep, Turkey
    J Pak Med Assoc 56:531-5. 2006
    ..Anticoagulant treatment with heparin is probably safe and beneficial for children with sinus thrombosis, even those with intracranial haemorrhages...
  69. ncbi [Cerebral venous thrombosis associated to subacute De Quervain's thyroiditis in a carrier for the G20210A mutation of the prothrombin gene]
    A B Madroñero-Vuelta
    Servicio de Medicina Interna, Hospital Universitario Arnau de Vilanova, Lleida, Spain
    Rev Neurol 39:533-5. 2004
    ..We present a case of CVT associated to a subacute De Quervain's thyroiditis in a young female who was an heterozygous carrier for the G20210A mutation of the prothrombin gene...
  70. ncbi [Cerebral venous thrombosis]
    J M Ferro
    Service de Neurologie, Hospital Santa Maria, 1649 035 Lisboa, Portugal
    J Neuroradiol 29:231-9. 2002
    ..There are few randomized trials upon which to base treatment recommendations...
  71. ncbi Genetics of cerebral venous thrombosis
    Arsalan Ahmad
    Section of Neurology, Shifa International Hospitals and College of Medicine, Islamabad
    J Pak Med Assoc 56:488-90. 2006
    ..Maternal and foetal testing is suggested when CVT occurs in neonates...
  72. ncbi Intracranial venous hemodynamics is a factor related to a favorable outcome in cerebral venous thrombosis
    Erwin Stolz
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Stroke 33:1645-50. 2002
    ..However, it is conceivable that the presence or absence and the efficiency of venous collaterals, as well as recanalization, may have an impact on brain tissue damage and hence on the prognosis of acute CVT...
  73. ncbi Cerebral venous thrombosis
    Isabelle Crassard
    Department of Neurology, Hopital Lariboisiere, Paris, France
    J Neuroophthalmol 24:156-63. 2004
    ..Cerebrospinal fluid diversion or optic nerve fenestration is used for vision-threatening papilledema when intracranial pressure control is difficult...
  74. ncbi Cerebral venous thrombosis and venous malformations in children
    Karen S Carvalho
    James Whitcomb Riley Hospital for Children, Section of Pediatric Neurology, Indiana University Medical Center, 702 Barnhill Drive, Room 1757, Indianapolis, IN 46202 5200, USA
    Neurol Clin 20:1061-77. 2002
    ..Awareness of these potential causes of stroke in the pediatric population, early diagnosis, and appropriate therapeutic strategies are paramount to reduce mortality and improve neurologic outcome...
  75. ncbi [Unilateral internal cerebral vein thrombosis in MRI]
    O Wittkugel
    Neuroradiologische Abteilung, Radiologische Klinik, Universitatsklinikum Hamburg Eppendorf
    Rofo 176:259-61. 2004
  76. pmc Recanalisation of cerebral venous thrombosis
    R W Baumgartner
    Department of Neurology, University Hospital of Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    J Neurol Neurosurg Psychiatry 74:459-61. 2003
    ..To investigate recanalisation in the first 12 months after cerebral venous thrombosis...
  77. ncbi [Therapeutic interventional neuroradiology in acute stroke]
    G Schroth
    Abteilung für Neuroradiologie DRNN Departement Radiologie, Neuroradiologie, Nuklearmedizin, Universität Bern im Inselspital, CH 3010 Bern
    Ther Umsch 60:569-83. 2003
    ..g., thrombolysis by ultrasound (sonothrombolysis), by angiojet aspiration, and laser evaporation of the thromboembolic occlusion of intra- and extracranial blood vessels...
  78. pmc Risk of recurrence of cerebral venous and sinus thrombosis during subsequent pregnancy and puerperium
    S Mehraein
    Department of Neurology, Charite Medical School, Humboldt Universitat, Berlin, Germany
    J Neurol Neurosurg Psychiatry 74:814-6. 2003
    ..To assess the risk of recurrence of cerebral venous and sinus thrombosis (CVST) during subsequent pregnancy and puerperium in women with previous cerebral venous occlusive disease...
  79. ncbi [Cerebral venous thrombosis. Clinical presentation of three cases]
    Mogens Kegel
    Røntgendiagnostisk Afdeling, Sønderborg Sygehus, Neurologisk afdeling N
    Ugeskr Laeger 165:1882-3. 2003
    ..The patients were treated with heparin. One developed blindness due to optic nerve atrophy. One had discreet cognitive deficits, and the last patient had no neurological sequelae after she was discharged from the hospital...
  80. ncbi Cerebral arterial thrombosis in paroxysmal nocturnal hemoglobinuria
    Sebastian von Stuckrad-Barre
    J Neurol 250:756-7. 2003
  81. ncbi Sinus thrombosis after a jump from a small rock and a sneezing attack: minor endothelial trauma as a precipitating factor for cerebral venous thrombosis?
    Carina Rottger
    Department of Neurology, University of Giessen, Germany
    Headache 44:812-5. 2004
    ..In about 20% of CVT cases the cause remains unclear. As minor head trauma may not have been recognized during history taking, this may represent a so far under-recognized precipitating factor for CVT...
  82. ncbi Small aneurysms as a cause of thromboembolic stroke
    M Smrcka
    Neurosurgical Department, University Hospital Brno, Czech Republic
    Bratisl Lek Listy 103:250-3. 2002
    ..Only a few examples are available in the literature of patients with smaller aneurysms who develop embolic infarction distal to the lesion. We have experience with two such patients with an apparent common pathophysiology...
  83. ncbi Intra-arterial thrombolysis of complete deep cerebral venous thrombosis
    M Liebetrau
    Department of Neurology, Klinikum Grosshadern, Munich, Germany
    Neurology 63:2444-5. 2004
  84. ncbi [Progression of cerebral venous thromboses. A retrospective study]
    G Rodier
    Service de Neurologie, Hôpital E Muller Mulhouse
    Presse Med 32:728-33. 2003
    ..Long term outcome of patients with cerebral venous thrombosis (CVT) has rarely been described. We present the results of a follow-up study...
  85. ncbi [A study on the diagnosis and etiology of cerebral venous thrombosis]
    Guihong Wang
    Department of Neurology, Tiantan Hospital, The Capital University of Medical Science, Beijing 100050, China
    Zhonghua Nei Ke Za Zhi 41:595-8. 2002
    ..To determine the clinical characteristic and common etiologies of cerebral venous thrombosis (CVT) in China...
  86. ncbi Cerebral venous thrombosis: correlation between recanalization and clinical outcome--a long-term follow-up of 40 patients
    M Strupp
    J Neurol 249:1123-4. 2002
  87. ncbi A novel method of drug delivery for fibrinolysis with Ho:YAG laser-induced liquid jet
    T Hirano
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Seiryou machi, Japan
    Lasers Med Sci 17:165-72. 2002
    ..After resolving some problems, this system will be applied to an endovascular therapy for cerebral embolisms in the near future...
  88. ncbi Extension of intracranial thrombosis after unilateral dissection of the internal jugular vein
    Eike Gunther Wüstenberg
    Department of Otorhinolaryngology, University Hospital Dresden, 01307 Dresden, Germany
    Arch Otolaryngol Head Neck Surg 131:430-3. 2005
    ..The aim of this study was to determine the extension of possible intracranial thrombosis after wound healing.
  89. ncbi Enhancement of fibrinolytics with a laser-induced liquid jet
    T Hirano
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1 1, Seiryou machi, Aoba ku, Sendai 980 8574, Japan
    Lasers Surg Med 29:360-8. 2001
    ..There is thus need of a new method of removing a cerebral thrombus more rapidly using smaller amounts of fibrinolytics...
  90. ncbi Snare retrieval of intracranial thrombus in patients with acute stroke
    Charles W Kerber
    Department of Radiology, University of California San Diego Medical Center, 200 West Arbor Drive, San Diego, California 92103, USA
    J Vasc Interv Radiol 13:1269-74. 2002
    ..This experience also suggests that immediate removal of a mature clot could reduce the total time of brain ischemia more quickly than administration of thrombolytic drugs...
  91. ncbi Intra-arterial tissue plasminogen activator for thrombosis complicating cerebral angiography in a 17-year-old girl
    Meredith R Golomb
    The Hospital for Sick Children, Toronto, Ontario
    J Child Neurol 18:420-3. 2003
    Few reports describe the use of intraarterial recombinant tissue plasminogen activator to treat intracranial thrombosis in children...
  92. ncbi Thrombosed fetal dural sinus malformation diagnosed with magnetic resonance imaging
    M Vittoria Spampinato
    Department of Radiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Obstet Gynecol 111:569-72. 2008
    ..Dural sinus malformations are rare congenital forms of dural arteriovenous shunt. Our goal is to describe prenatal ultrasonography and magnetic resonance imaging (MRI) findings of a thrombosed midline dural venous malformation...
  93. pmc Molecular MRI of intracranial thrombus in a rat ischemic stroke model
    Ritika Uppal
    Department of Radiology, Massachusetts General Hospital East, 149 13th Street, Suite 2301, Charlestown, MA 02129, USA
    Stroke 41:1271-7. 2010
    ..In this study, we examined whether this fibrin-specific MR probe could noninvasively characterize intracranial arterial thrombi...
  94. ncbi Intraarterial reteplase and intravenous abciximab for treatment of acute ischemic stroke. A preliminary feasibility and safety study in a non-human primate model
    Adnan I Qureshi
    Zeenat Qureshi Stroke Research Center, The University of Medicine and Dentistry of New Jersey, DOC 8100, 90 Bergen Street, Newark, NJ 07103, USA
    Neuroradiology 47:845-54. 2005
    ..with intraarterial (IA) administration of a thrombolytic agent (reteplase) in a primate model of intracranial thrombosis. We introduced thrombus through superselective catheterization of the intracranial segment of the ..
  95. ncbi Determination and pharmacokinetic study of taxifolin in rabbit plasma by high-performance liquid chromatography
    Olga N Pozharitskaya
    Interregional Center Adaptogen, 47 5 Piskarevsky pr, 195067 St Petersburg, Russia
    Phytomedicine 16:244-51. 2009
    ..The absolute bioavailability of taxifolin after oral administration of lipid solution was 36%...
  96. pmc Formation of a Liquid Jet by Interaction between a Laser-induced Bubble and a Shock Wave
    T Hirano
    Department of Neurosurgery Tohoku University Graduate School of Medicine, Shock Wave Research Center Institute of Fluid Science, Tohoku University Sendai, Japan
    Interv Neuroradiol 7:35-40. 2001
    ..2 mm, which was nearly twice deeper than the laser irradiation only (2.2 mm). Combination of this liquid jet and fibrinolytics will realize more rapid recanalization with fewer drugs...
  97. ncbi Malignant profile detected by CT angiographic information predicts poor prognosis despite thrombolysis within three hours from symptom onset
    Volker Puetz
    Department of Neurology, Dresden University Stroke Center, University of Technology Dresden, Dresden, Germany
    Cerebrovasc Dis 29:584-91. 2010
    ..We sought to determine whether CT angiography (CTA) could identify a malignant imaging profile within 3 h from symptom onset...
  98. ncbi [Thrombus of the left lateral sinus spreading to the internal jugular vein]
    J C Lacour
    Service de Neurologie, Hopital Neurologique, 54035 Nancy Cedex
    Rev Neurol (Paris) 159:451-4. 2003
    ..The time course of the symptoms suggested that intracranial thrombosis occurred first...
  99. ncbi CT angiography in the rapid triage of patients with hyperacute stroke to intraarterial thrombolysis: accuracy in the detection of large vessel thrombus
    M H Lev
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 9657, USA
    J Comput Assist Tomogr 25:520-8. 2001
    ..The purpose of this work was to evaluate the accuracy of CT angiography (CTA) for the detection of large vessel intracranial thrombus in clinically suspected hyperacute (<6 h) stroke patients...
  100. ncbi [Headaches in a 21-year-old man with Goodpasture disease]
    J S Petit
    Unité de réanimation polyvalente, Hopital Maison Blanche, 45, rue Cognacq Jay, 51092 Reims Cedex, France
    Ann Fr Anesth Reanim 28:799-802. 2009
    The case of a 21-year old man who died due to an intracranial thrombosis just after diagnosis of Goodpasture's disease, is reported. Discussion deals with the putative mechanisms, which could be responsible for the thrombosis.
  101. ncbi Case report of a patient who underwent thrombolysis of a "silent" thrombus in the middle cerebral artery
    Titto T Idicula
    Haukeland University Hospital, Bergen, Norway
    Neurologist 15:142-3. 2009
    ..Thrombolysis might be beneficial in these patients in spite of the lack of measurable neurologic deficits. We present a patient with a 'silent' thrombus in the middle cerebral artery...

Research Grants19

  1. Outcomes of Perinatal Stroke
    Meredith Golomb; Fiscal Year: 2008
    ..During the last year of the study, she plans to apply for an R01 grant to set up a pilot clinical trial. [unreadable] [unreadable]..
  2. Genetic Markers of Thrombosis in Embolic Stroke
    Karen Furie; Fiscal Year: 2006
    ....
  3. 26th Princeton Conference on Cerebrovascular Disease
    James Grotta; Fiscal Year: 2008
    ..All presentations and discussion will be recorded and published. [unreadable] [unreadable] [unreadable]..
  4. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  5. Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    William C Culp; Fiscal Year: 2010
    ..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..
  6. Screening Technology and Outcomes Project in Stroke
    Karen Furie; Fiscal Year: 2005
    ..abstract_text> ..
  7. Photothrombotic Brain Infarction and Epileptogenesis
    Kevin Kelly; Fiscal Year: 2005
    ..abstract_text> ..
  8. CALCIUM BLOCKER AND RELATED THERAPY FOR STROKE RECOVERY
    James Grotta; Fiscal Year: 2004
    ....
  9. Stroke Hospitalization in the Elderly with Medicare FFS
    Judith Lichtman; Fiscal Year: 2009
    ..These results will help inform decisions about the allocation of adequate resources, and more importantly, help identify opportunities to improve care and prevention of elderly stroke patients. ..
  10. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2004
    ..We anticipate that the study findings will suggest the use of new evaluation and therapeutic strategies, which will significantly decrease the age associated mortality and morbidity in post-infarction patients. ..
  11. RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODEL
    Michael Lawton; Fiscal Year: 2004
    ..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs. ..
  12. Effects of Stress on Pathology of Parkinson's Disease
    GERLINDE METZ; Fiscal Year: 2004
    ..These approaches will provide the opportunity to understand factors involved in the pathology of PD and to develop novel therapeutic strategies for neurodegenerative motor disorders. ..
  13. Middle Cerebral and Common Artery Occlusion and Poststroke Epilepsy
    Kevin Kelly; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  14. Safety and Tolerability of Deferoxamine in Acute Cerebral Hemorrhage
    Magdy H Selim; Fiscal Year: 2010
    ..ICH is a frequent cause of disability and death. A successful study demonstrating the efficacy of iron-modifying therapy would be of considerable public health significance. ..
  15. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  16. Impact of Aging on Stroke Care: A National Perspective
    Judith Lichtman; Fiscal Year: 2004
    ..We hypothesize that variations in care exist by age. Moreover, these differences in care will not be explained by differences clinical features or co-morbid conditions associated with aging. ..
  17. PARAMEDIC FIELD INITIATION OF MAGNESIUM NEUROPROTECTIVE
    Jeffrey Saver; Fiscal Year: 2003
    ..abstract_text> ..