intracranial embolism

Summary

Summary: Migration of foreign material to the intracranial components of the nervous system via arterial pathways. Emboli most frequently are of cardiac origin and are associated with ARRHYTHMIA; mural thrombi; ENDOCARDITIS, SUBACUTE BACTERIAL; HEART VALVE DISEASES; and HEART SEPTAL DEFECTS. Noncardiac sources include lesions of the aorta, carotid arteries, vertebral arteries, and intracranial arteries. Emboli may be composed of thrombosed platelets, atherosclerotic debris, fat, air, tumor cells, or infectious materials, and may cause CEREBRAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp824-6)

Top Publications

  1. ncbi Cerebral protection during carotid stenting using flow reversal
    Juan C Parodi
    Vascular Surgery Division, Fundación de Lucha Contra las Enfermedades Neurológicas, Montaneses 2325, Ciudad de Buenos Aires C1428AQK, Argentina
    J Vasc Surg 41:416-22. 2005
  2. ncbi Cerebral embolism following transcatheter aortic valve implantation: comparison of transfemoral and transapical approaches
    Josep Rodes-Cabau
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 57:18-28. 2011
  3. ncbi Transcranial Doppler sound detection of cerebral microembolism during transapical aortic valve implantation
    T Drews
    Deutsches Herzzentrum Berlin, Berlin, Germany
    Thorac Cardiovasc Surg 59:237-42. 2011
  4. ncbi Magnetic resonance imaging evaluation of cerebral embolization during percutaneous aortic valve implantation: comparison of transfemoral and trans-apical approaches using Edwards Sapiens valve
    Parla Astarci
    Cardiovascular and Thoracic Surgery Department University Hospital Saint Luc, Brussels, Belgium
    Eur J Cardiothorac Surg 40:475-9. 2011
  5. ncbi Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke
    J Montaner
    Cerebrovascular Unit, Vall d Hebron Hospital, Barcelona, Spain
    Stroke 32:2762-7. 2001
  6. ncbi Carotid artery stenting protected with an emboli containment system
    Patrick L Whitlow
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Stroke 33:1308-14. 2002
  7. ncbi A new endoluminal, flow-disrupting device for treatment of saccular aneurysms
    David F Kallmes
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Stroke 38:2346-52. 2007
  8. pmc Cerebral lipiodol embolism following transcatheter arterial chemoembolization for hepatocellular carcinoma
    Lu Wu
    The First Department of Interventional Radiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
    World J Gastroenterol 16:398-402. 2010
  9. ncbi Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literature
    Andreas Kastrup
    Department of Neurology, University of Tubingen, Tubingen, Germany
    Stroke 34:813-9. 2003
  10. ncbi Cerebral microembolization after protected carotid artery stenting in surgical high-risk patients: results of a 2-year prospective study
    Frank D Hammer
    Department of Radiology, University Hospital St Luc, Brussels, Belgium
    J Vasc Surg 42:847-53; discussion 853. 2005

Research Grants

  1. AGING AND COGNITION AFTER CARDIAC SURGERY
    Mark Newman; Fiscal Year: 2003
  2. Quality Improvement and Outcomes for Strokes After CABG
    DONALD LIKOSKY; Fiscal Year: 2004
  3. Aging, Vascular Disease and Cognition
    David Moser; Fiscal Year: 2007
  4. HARMONIC DOPPLER ULTRASOUND EMBOLUS CHARACTERIZATION
    MARK MOEHRING; Fiscal Year: 2006
  5. Mechanisms of Radiation-Induced Cognitive Dysfunction
    William Brown; Fiscal Year: 2008
  6. Treatment of Acute Embolic Stroke with Statins and rt-PA
    Zheng Gang Zhang; Fiscal Year: 2009
  7. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2009
  8. Induced Hypertension for Acute Ischemic Stroke
    Robert Wityk; Fiscal Year: 2004
  9. THE ROLE OF LYMPHOCYTES IN CEREBRAL ISCHEMIC INJURY
    Kyra Becker; Fiscal Year: 2004
  10. MRI AND RT PA TREATMENT OF EMBOLIC STROKE
    Quan Jiang; Fiscal Year: 2003

Detail Information

Publications221 found, 100 shown here

  1. ncbi Cerebral protection during carotid stenting using flow reversal
    Juan C Parodi
    Vascular Surgery Division, Fundación de Lucha Contra las Enfermedades Neurológicas, Montaneses 2325, Ciudad de Buenos Aires C1428AQK, Argentina
    J Vasc Surg 41:416-22. 2005
    ..Carotid angioplasty and stenting can be used in stroke prevention in high-risk patients. As embolic complications can occur during carotid angioplasty and stenting, a device was developed to protect from cerebral embolization...
  2. ncbi Cerebral embolism following transcatheter aortic valve implantation: comparison of transfemoral and transapical approaches
    Josep Rodes-Cabau
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 57:18-28. 2011
    ....
  3. ncbi Transcranial Doppler sound detection of cerebral microembolism during transapical aortic valve implantation
    T Drews
    Deutsches Herzzentrum Berlin, Berlin, Germany
    Thorac Cardiovasc Surg 59:237-42. 2011
    ..However, whether it usually occurs, how often, and its clinical relevance are not known. We report the results of ultrasound microembolic signal detection in the middle cerebral artery during the procedure...
  4. ncbi Magnetic resonance imaging evaluation of cerebral embolization during percutaneous aortic valve implantation: comparison of transfemoral and trans-apical approaches using Edwards Sapiens valve
    Parla Astarci
    Cardiovascular and Thoracic Surgery Department University Hospital Saint Luc, Brussels, Belgium
    Eur J Cardiothorac Surg 40:475-9. 2011
    ..Therefore, we compared the rate of cerebral embolisms with diffusion-weighted magnetic resonance imaging (DWI) in transfemoral (TF) and trans-apical (TA) approaches...
  5. ncbi Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke
    J Montaner
    Cerebrovascular Unit, Vall d Hebron Hospital, Barcelona, Spain
    Stroke 32:2762-7. 2001
    ..MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-treated animals. We aimed to determine the relationship between MMPs and HT after human ischemic stroke...
  6. ncbi Carotid artery stenting protected with an emboli containment system
    Patrick L Whitlow
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Stroke 33:1308-14. 2002
    ..Fear of distal embolization and stroke has aroused concern regarding carotid stenting. Devices to protect the cerebral circulation may make carotid stenting safer...
  7. ncbi A new endoluminal, flow-disrupting device for treatment of saccular aneurysms
    David F Kallmes
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Stroke 38:2346-52. 2007
    ....
  8. pmc Cerebral lipiodol embolism following transcatheter arterial chemoembolization for hepatocellular carcinoma
    Lu Wu
    The First Department of Interventional Radiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
    World J Gastroenterol 16:398-402. 2010
    ....
  9. ncbi Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literature
    Andreas Kastrup
    Department of Neurology, University of Tubingen, Tubingen, Germany
    Stroke 34:813-9. 2003
    ....
  10. ncbi Cerebral microembolization after protected carotid artery stenting in surgical high-risk patients: results of a 2-year prospective study
    Frank D Hammer
    Department of Radiology, University Hospital St Luc, Brussels, Belgium
    J Vasc Surg 42:847-53; discussion 853. 2005
    ....
  11. ncbi Dual antiplatelet therapy monitoring for neurointerventional procedures using a point-of-care platelet function test: a single-center experience
    D H Lee
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    AJNR Am J Neuroradiol 29:1389-94. 2008
    ..We present our initial experience with a new point-of-care antiplatelet-function test (VerifyNow assay) in neurointerventional procedures...
  12. pmc Cognitive function after transapical aortic valve implantation: a single-centre study with 3-month follow-up
    Stephan C Knipp
    Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, Essen, Germany
    Interact Cardiovasc Thorac Surg 16:116-22. 2013
    ..In this study, we prospectively examined neurological and cognitive outcomes in patients undergoing transapical (TA) and surgical aortic valve replacement (AVR)...
  13. ncbi Embolic cerebral insults after transapical aortic valve implantation detected by magnetic resonance imaging
    Martin Arnold
    Department of Cardiology, University Hospital Erlangen, Erlangen, Germany
    JACC Cardiovasc Interv 3:1126-32. 2010
    ..This study assessed the rate of periprocedural embolic ischemic brain injury during transapical aortic valve replacement in 25 consecutive patients...
  14. ncbi An embolic deflection device for aortic valve interventions
    Fabian Nietlispach
    Department of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    JACC Cardiovasc Interv 3:1133-8. 2010
    ..We describe initial human experience with a novel cerebral embolic protection device...
  15. ncbi First-in-man use of a novel embolic protection device for patients undergoing transcatheter aortic valve implantation
    Christoph K Naber
    Contilia Heart and Vascular Center, Elisabeth Krankenhaus Essen, Essen, Germany
    EuroIntervention 8:43-50. 2012
    ..We aimed to evaluate the feasibility and safety of the Claret CE Pro™ cerebral protection device in patients undergoing TAVI...
  16. ncbi Detection of clinically silent infarcts after carotid endarterectomy by use of diffusion-weighted imaging
    R J Feiwell
    Department of Neurology, University of California, San Francisco 94143, USA
    AJNR Am J Neuroradiol 22:646-9. 2001
    ..An important next step is to determine the risk factors that predispose to detectable parenchymal ischemic events...
  17. ncbi Risk and fate of cerebral embolism after transfemoral aortic valve implantation: a prospective pilot study with diffusion-weighted magnetic resonance imaging
    Alexander Ghanem
    Department of Medicine Cardiology, University of Bonn, Bonn, Germany
    J Am Coll Cardiol 55:1427-32. 2010
    ..The aim of this study was prospective investigation of silent and clinically apparent cerebral embolic events and neurological impairment after transfemoral aortic valve implantation (TAVI)...
  18. ncbi Patency of cerebral microvessels after focal embolic stroke in the rat
    C X Wang
    Department of Neurology, University of Alberta, Edmonton, Alberta, Canada
    J Cereb Blood Flow Metab 21:413-21. 2001
    ..These results may in part explain the resistance of the striatum to neuroprotective strategies used for the treatment of focal cerebral ischemia...
  19. ncbi Carotid stenting with distal protection in high surgical risk patients: the BEACH trial 30 day results
    Christopher J White
    Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Catheter Cardiovasc Interv 67:503-12. 2006
    ..The BEACH trial evaluated the outcomes of carotid artery stent placement with distal emboli protection, using the Carotid Wallstent and the FilterWire EX/EZ(TM), in patients at high surgical risk for carotid endarterectomy (CEA)...
  20. ncbi First-in-man experience with a new embolic deflection device in transcatheter aortic valve interventions
    Kevin Onsea
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    EuroIntervention 8:51-6. 2012
    ..The application of a temporary filter in the aortic arch averting dislodged emboli from entering the cerebral circulation might prevent this...
  21. ncbi Silent embolism in diagnostic cerebral angiography: detection with diffusion-weighted imaging
    Kenneth C Chuah
    Department of Radiology, The Alfred Hospital, Melbourne, Victoria, Australia
    Australas Radiol 48:133-8. 2004
    ..Diffusion-weighted imaging might therefore provide an easier method of assessing complication rates in cerebral angiography by reducing the number of patients required for meaningful statistical analysis...
  22. ncbi Cerebral protection during carotid artery stenting: collection and histopathologic analysis of embolized debris
    Annalisa Angelini
    Department of Pathology, University of Padua Medical School, Italy
    Stroke 33:456-61. 2002
    ..Histopathologic analysis was performed to better understand quantity, particle size, and composition of embolized debris collected in protection filters during carotid artery stent implantation...
  23. ncbi Diffusion-weighted MR imaging lesions after filter-protected stenting of high-grade symptomatic carotid artery stenoses
    R du Mesnil de Rochemont
    Institute of Neuroradiology, Klinikum der Johann Wolfgang Goethe Universität Frankfurt Main, Schleusenweg 2 16, 60 528 Frankfurt am Main, Germany
    AJNR Am J Neuroradiol 27:1321-5. 2006
    ..The aim of this retrospective study was to assess the number and extent of cerebral emboli, as represented by new lesions on diffusion-weighted MR imaging (DWI), in patients treated with filter-protected carotid stent placement...
  24. ncbi Injection of air bubbles during flushing of angiocatheters: an in vitro trial of conventional hardware and techniques
    A C Mamourian
    Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    AJNR Am J Neuroradiol 22:709-12. 2001
    ..Degassing the solution and delaying injection decreased the number of bubble events noted in model 2. CONCLUSION: Bubble emboli are commonplace during flushing of angiography catheters when using conventional techniques and equipment...
  25. ncbi Symptomatic cerebral air embolism during neuro-angiographic procedures: incidence and problem avoidance
    Rishi Gupta
    Department of Neurology, Michigan State University, Lansing, MI, USA
    Neurocrit Care 7:241-6. 2007
    ..Understanding this complication's frequency and etiology is critical if systems are to be instituted to reduce its incidence...
  26. ncbi Cerebral lipiodol embolism during transcatheter arterial chemoembolization
    K M Yoo
    Department of Neurology, Kosin University College of Medicine, 34 Amnam dong, Seo Gu, Busan, Korea
    Neurology 63:181-3. 2004
    ..Clinical signs completely resolved and MRI lesions markedly improved on follow-up evaluation within a 3-week period...
  27. ncbi Diffusion-weighted MR imaging after angioplasty or angioplasty plus stenting of arteries supplying the brain
    H J Jaeger
    Department of Radiology, Staedtische Kliniken Dortmund, University Witten/Herdecke, D-44139 Dortmund, Germany
    AJNR Am J Neuroradiol 22:1251-9. 2001
    ..Diffusion-weighted MR imaging of the brain can be used as a tool to assess the impact of modifications of procedural technique and/or the use of cerebral protection devices on the occurrence of such lesions...
  28. ncbi Gas generation and clot formation during electrolytic detachment of Guglielmi detachable coils: in vitro observations and animal experiment
    Moon Hee Han
    Department of Radiology, Seoul National University College of Medicine, Korea
    AJNR Am J Neuroradiol 24:539-44. 2003
    ..The purpose of this study was to investigate electrolysis-related changes of blood as a potential cause of thromboembolic complications associated with GDC use...
  29. ncbi Multiple ischemic strokes after transcatheter arterial chemoembolization for hepatocellular carcinoma with a radiographic and pathological correlate
    Victor Zach
    Department of Neurology, The Mount Sinai School of Medicine, New York, New York, USA
    J Stroke Cerebrovasc Dis 21:217-24. 2012
    ..Transcatheter arterial chemoembolization (TACE) is a widely used form of therapy in advanced hepatocellular carcinoma. We report the first pathological data from an autopsy case of multiple cerebral emboli occurring during TACE...
  30. ncbi Silent thromboembolic events associated with the treatment of unruptured cerebral aneurysms by use of Guglielmi detachable coils: prospective study applying diffusion-weighted imaging
    G Rordorf
    Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    AJNR Am J Neuroradiol 22:5-10. 2001
    ..Although clinical sequelae are rare, the high rate of occurrence suggests that alterations in the technique, such as the addition of antiplatelet agents, should be considered...
  31. ncbi Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism
    Feng Han
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Neurosci Lett 430:275-80. 2008
    ..Taken together, downregulation of glutamate transporters after ME is associated with dysregulation of basal glutamate concentrations and KCl-induced glutamate release in the brain...
  32. ncbi Safety and efficacy of adjunctive balloon remodeling during endovascular treatment of intracranial aneurysms: a literature review
    M Shapiro
    Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA
    AJNR Am J Neuroradiol 29:1777-81. 2008
    ..Nevertheless, there exists concern that adjunctive use of balloon assistance may lead to increased adverse events during aneurysm coiling...
  33. pmc Four cases of a cerebral air embolism complicating a percutaneous transthoracic needle biopsy
    Soo Jung Um
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
    Korean J Radiol 10:81-4. 2009
    ..Early diagnosis and the rapid application of hyperbaric oxygen therapy is the mainstay of therapy for an embolism. Prevention is the best course and it is essential that possible risk factors be avoided...
  34. ncbi Thromboembolic events associated with Guglielmi detachable coil embolization with use of diffusion-weighted MR imaging. Part II. Detection of the microemboli proximal to cerebral aneurysm
    Akio Soeda
    Department of Neurosurgery, National Cardiovascular Center, Osaka, Japan
    AJNR Am J Neuroradiol 24:2035-8. 2003
    ....
  35. ncbi Cardioembolic stroke: an update
    Jose M Ferro
    Stroke Unit, Department of Neurology, Hospital de Santa Maria, Faculdade de Medicina de Lisboa, Lisbon, Portugal
    Lancet Neurol 2:177-88. 2003
    ..Available evidence does not support routine immediate anticoagulation of acute cardioembolic stroke...
  36. ncbi Early diagnosis of cerebral fat embolism syndrome by diffusion-weighted MRI (starfield pattern)
    P M Parizel
    Department of Radiology, Intensive Care Medicine, Orthopedic Surgery, Universitair Ziekenhuis Antwerpen, Edegem, Belgium
    Stroke 32:2942-4. 2001
    ..We suggest that this indicates areas of restricted diffusion that are due to cytotoxic edema, resulting from multiple microemboli...
  37. ncbi Cerebral gas embolism due to upper gastrointestinal endoscopy
    Mark ter Laan
    Department of Medical Center Leeuwarden, Leeuwarden, The Netherlands
    Eur J Gastroenterol Hepatol 21:833-5. 2009
    ..The aetiology and treatment is discussed based on the reviewed literature. Once cerebral gas emboli are recognized, patient outcome can be improved by hyperbaric oxygen therapy...
  38. ncbi Specific cardiac disorders in 402 consecutive patients with ischaemic cardioembolic stroke
    Ramon Pujadas Capmany
    Service of Cardiology, Hospital del Sagrat Cor, C Viladomat 288, E 08029 Barcelona, Spain
    Int J Cardiol 95:129-34. 2004
    ..To determine the cardiological substrate in acute stroke patients presenting with a cardioembolic stroke subtype...
  39. pmc Extension of the thrombolytic time window with minocycline in experimental stroke
    Yoshihiro Murata
    Neuroprotection Res Lab, Charlestown, MA 02129, USA
    Stroke 39:3372-7. 2008
    ..In this study, we ask whether minocycline can prevent tPA-associated cerebral hemorrhage and extend the reperfusion window in an experimental stroke model in rats...
  40. pmc Relevance of postmortem radiology to the diagnosis of fatal cerebral gas embolism from compressed air diving
    A J Cole
    Department of Radiology, The Townsville Hospital, Douglas, Queensland, Australia
    J Clin Pathol 59:489-91. 2006
    ..To test the hypothesis that artefact caused by postmortem off-gassing is at least partly responsible for the presence of gas within the vascular system and tissues of the cadaver following death associated with compressed air diving...
  41. ncbi Prevalence and prognostic impact of microembolic signals in arterial sources of embolism. A systematic review of the literature
    Martin A Ritter
    Dept of Neurology, University of Munster, Albert Schweitzer Str 33, 48129 Munster, Germany
    J Neurol 255:953-61. 2008
    ..We investigated prevalences of MES and whether MES detection is of proven use for risk stratification...
  42. ncbi Online automatic discrimination between solid and gaseous cerebral microemboli with the first multifrequency transcranial Doppler
    David Russell
    Department of Neurology, The National Hospital, Oslo, Norway
    Stroke 33:1975-80. 2002
    ..The aim of this study was to assess the first multifrequency transcranial Doppler system that was specially developed to automatically detect and discriminate between solid and gaseous cerebral microemboli...
  43. ncbi Cerebral fat embolism: pulmonary contusion is a more important etiology than long bone fractures
    M D Aydin
    Department of Neurosurgery, Medical Faculty, Ataturk University, Erzurum, Turkey
    Clin Neuropathol 24:86-90. 2005
    ..In conclusion, we found that pulmonary contusion had more deleterious effects than long bone fracture in the formation of cerebral fat embolism...
  44. ncbi Microembolic signal monitoring in hemispheric acute ischaemic stroke: a prospective study
    J Serena
    Section of Neurology and Stroke Research Unit, Hospital Universitari Doctor Josep Trueta, Girona, Spain
    Cerebrovasc Dis 10:278-82. 2000
    ....
  45. ncbi Influence of inflammation and pump dynamic on cerebral microembolization in patients with Continuous-Flow DeBakey LVAD
    Nils H Thoennissen
    Department of Neurology, University of Munster, Munster, Germany
    ASAIO J 52:243-7. 2006
    ..We hypothesize that a gaseous nature of the majority of detected microemboli in the DeBakey LVAD may be the underlying reason for this discrepancy...
  46. ncbi Air embolism detected during computed tomography fluoroscopically guided transthoracic needle biopsy
    Satoshi Hirasawa
    Department of Diagnostic and Interventional Radiology, Gunma Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Cardiovasc Intervent Radiol 31:219-21. 2008
    ..We report a case of cerebral air embolism which occurred during computed tomography (CT)-guided needle biopsy. Air entering the aorta is depicted on CT-fluoroscopy images of the procedure...
  47. ncbi Embolic signals in unselected stroke patients: prevalence and diagnostic benefit
    Holger Poppert
    Department of Neurology, Klinikum rechts der Isar, Munich University of Technology, Moehlstr 28, 81675 Muenchen, Germany
    Stroke 37:2039-43. 2006
    ..We aimed to evaluate the feasibility and the value of the method for clinical use...
  48. ncbi Efficacy of a proximal occlusion catheter with reversal of flow in the prevention of embolic events during carotid artery stenting: an experimental analysis
    T Ohki
    Division of Vascular Surgery, Department of Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA
    J Vasc Surg 33:504-9. 2001
    ..In addition, pressure measurements relevant to the clinical application of this device were obtained from 10 patients undergoing carotid endarterectomy...
  49. ncbi Neurological outcome of septic cardioembolic stroke after infective endocarditis
    Elfriede Ruttmann
    Department of Cardiac Surgery, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Stroke 37:2094-9. 2006
    ..The aim of this study was to evaluate mortality and neurological outcomes of cardioembolic cerebral stroke in infective endocarditis (IE) patients requiring cardiac surgery...
  50. ncbi Cerebral microembolus detection in an unselected acute ischemic stroke population
    C Lund
    Department of Neurology, The National Hospital, University of Oslo, Norway
    Cerebrovasc Dis 10:403-8. 2000
    ....
  51. ncbi Doppler microembolic load predicts risk of thromboembolic complications in Novacor patients
    Darius G Nabavi
    Department of Neurology, University of Munster, Germany
    J Thorac Cardiovasc Surg 126:160-7. 2003
    ..We evaluated the value of microembolic signals in predicting thromboembolic events for individual patients and distinctive left ventricular assist device periods...
  52. ncbi Effects of cerebral air embolism on brain metabolism in pigs
    R A van Hulst
    Department of Anesthesiology, Erasmus Medical Centre Rotterdam, The Netherlands
    Acta Neurol Scand 108:118-24. 2003
    ..Cerebral air embolism was induced in pigs and changes in intracranial pressure (ICP), brain oxygen (PbrO2), brain carbon dioxide (PbrCO2), brain pH (brpH) and glucose, lactate and pyruvate levels were used to characterize this model...
  53. ncbi Heparin and air filters reduce embolic events caused by intra-arterial cerebral angiography: a prospective, randomized trial
    Martin Bendszus
    Department of Neuroradiology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Circulation 110:2210-5. 2004
    ..Intra-arterial cerebral angiography is associated with a low risk for neurological complications, but clinically silent ischemic events after angiography have been seen in a substantial number of patients...
  54. ncbi Micro embolic signals in patients with cerebral ischaemic events
    D Gucuyener
    Department of Neurology, Osmangazi University, Meselik 26480, Eskisehir, Turkey
    Neurol India 49:225-30. 2001
    ..0%) or transient ischaemic attacks (27.3%). A correlation of MES and neuroimaging finding was also tried. TCD was found to have a predictive role in microemboli monitoring, predominantly in patients with large vessel territory infarction...
  55. ncbi Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke
    P A Lapchak
    Department of Neuroscience, University of California at San Diego, La Jolla 92093 0624, USA
    Stroke 31:3034-40. 2000
    ....
  56. ncbi Cerebral air embolism complicating cardiac ablation procedures
    D A Hinkle
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Neurology 56:792-4. 2001
    ..Hyperbaric oxygen therapy, combined with aggressive resuscitative efforts, appears to have contributed to each patient's recovery...
  57. ncbi Quantification of embolic showers using radio-frequency based TCD analysis
    M G A Lipperts
    Department of Cardiothoracic Surgery, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, Maastricht, The Netherlands
    Ultrasound Med Biol 35:395-402. 2009
    ..RF-based emboli detection can possibly become a standard addition to conventional Doppler methods, considering that accurate estimation of the embolic load supports quantification of neurologic risk during various surgical procedures...
  58. pmc Cerebral ischemia detected with diffusion-weighted MR imaging after protected carotid artery stenting: comparison of distal balloon and filter device
    Suk Jung Kim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Radiol 8:276-85. 2007
    ..The aim of this study was to examine the incidence of ischemia during protected carotid artery stenting (CAS) as well as to compare the protective efficacy of the balloon and filter devices on diffusion-weighted MR imaging (DWI)...
  59. ncbi Microembolic signals and clinical outcome in patients with acute stroke--a prospective study
    A Delcker
    Department of Neurology, University of Essen, Germany
    Eur Arch Psychiatry Clin Neurosci 250:1-5. 2000
    ..The prevalence of MES or the MES rate, found after a short time interval to the onset of symptoms, did not have a prognostic value on the outcome of neurological deficits up to a three month follow-up...
  60. ncbi Long-term functional and neurological outcome after simultaneous treatment with tissue-plasminogen activator and hyperbaric oxygen in early phase of embolic stroke in rats
    Dominik Michalski
    Department of Neurology, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
    Brain Res 1303:161-8. 2009
    ..Future studies should focus on interactions of tPA and HBO on molecular level leading to delayed damage to brain tissue at risk...
  61. ncbi Patent foramen ovale and cerebrovascular diseases
    Amish J Desai
    Department of Cardiovascular Research, Swedish Medical Center, Seattle, WA 98104, USA
    Nat Clin Pract Cardiovasc Med 3:446-55. 2006
    ..In this review we discuss embryologic origins, diagnostic techniques and treatment options for prevention of paradoxical embolism thought to be related to PFO, and the relation of PFO to cryptogenic stroke and migraine...
  62. ncbi Silent cerebral ischemia detected by diffusion-weighted MRI after carotid endarterectomy
    A Barth
    Department of Neurosurgery, University of Berne, Inselspital, DKNS, Switzerland
    Stroke 31:1824-8. 2000
    ..We also tried to correlate postoperative ischemic lesions with the occurrence of sonographic cerebral embolic signals, the presence of plaque ulcerations, and the use of intraoperative shunting...
  63. ncbi Feasibility trial of carotid stenting with and without an embolus protection device
    Kenneth Ouriel
    Department of Surgery, The Cleveland Foundation, OH 44195, USA
    J Endovasc Ther 12:525-37. 2005
    ..To evaluate the feasibility of stenting and cerebral protection in patients with carotid bifurcation disease...
  64. ncbi Diffusion-weighted magnetic resonance imaging in carotid angioplasty and stenting with balloon embolic protection devices
    Fumio Asakura
    Department of Neurosurgery, Mie University School of Medicine, 2 174, Edobashi, 514 8507, Tsu City, Mie Prefecture, Japan
    Neuroradiology 48:100-12. 2006
    ..9%) and vertebrobasilar territory (25.3%). Better protection was obtained with simultaneous double occlusion of both the internal and external carotid artery than with single protection of the internal carotid artery during CAS...
  65. ncbi Cerebral lipiodol embolism: a complication of transcatheter arterial chemoembolization for hepatocellular carcinoma
    Koichi Matsumoto
    Department of Radiology, Saga Medical School, 5 1 1 Nabeshima, Saga, 849 8501, Japan
    Cardiovasc Intervent Radiol 30:512-4. 2007
    ..Despite intensive care, the patient died 2 weeks later. The complication might have been due to systemic-pulmonary shunts caused by previous surgeries and/or direct invasion of the recurrent tumor...
  66. ncbi Assessment of silent embolism from carotid endarterectomy by use of diffusion-weighted imaging: work in progress
    K P Forbes
    Divisions of Neuroradiology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA
    AJNR Am J Neuroradiol 22:650-3. 2001
    ..CONCLUSION: There is no evidence from our series that silent cerebral infarction is a common occurrence during CEA. These data provide further support for the safety of CEA...
  67. ncbi Brain embolism - Answers to practical questions
    Jose M Ferro
    Stroke Unit, Neurology Department, Centro de Estudos Egas Moniz, Hospital de Santa Maria, 1649 035 Lisboa, Portugal
    J Neurol 250:139-47. 2003
    ..The embolic risk of patent foramen ovale is low except when combined with an atrial septal aneurysm. Available evidence does not support routine immediate anticoagulation of acute cardioembolic stroke...
  68. ncbi Fatal scuba diving incident with massive gas embolism in cerebral and spinal arteries
    C Ozdoba
    Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Switzerland
    Neuroradiology 47:411-6. 2005
    ..These findings were confirmed at autopsy. Appropriate imaging techniques can help forensic pathologists to aim their autopsies at findings that might otherwise remain undetected...
  69. ncbi Carotid stenting with filter protection. Correlation of ACT values with angiographic and histopathologic findings
    L Castellan
    Neuroradiology Department, S Bortolo Hospital, Vicenza, Italy
    J Neuroradiol 30:103-8. 2003
    ..Angiographic findings (filter patency), pathological analysis of the collected materials inside the filters and coagulation parameters were analyzed to identify potential down sides in the use of these protection devices...
  70. ncbi Is 15 mm size criterion for lacunar infarction still valid? A study on strictly subcortical middle cerebral artery territory infarction using diffusion-weighted MRI
    A Hyun Cho
    Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Songpa Gu, Seoul, Korea
    Cerebrovasc Dis 23:14-9. 2007
    ..We sought to assess whether the lacunar hypothesis based on size is still valid...
  71. ncbi Carotid artery stenting in surgical high-risk patients
    Majdi Halabi
    Division of Invasive Cardiology, Rambam Medical Center and Technion Israel Institute of Technology, Haifa, Israel
    Catheter Cardiovasc Interv 67:513-8. 2006
    ..In both types of lesions, acceptable results justify its use as a valid revascularization method. While clinical embolic events occur in a minority of patients in both lesion types, they are not entirely prevented by distal protection...
  72. ncbi Internal carotid artery stent placement without emboli protection: results and long-term outcome
    D Bibl
    Division of Neurology and Psychiatry, Linz General Hospital, Krankenhausstrasse 9, A 4020 Linz, Austria
    Neurology 65:132-4. 2005
    ..Stroke and death from stroke occurred within 30 days after stenting in 4.7% of the symptomatic and in 3.0% of the asymptomatic patients and in the follow-up period in 2.3% of the symptomatic and in 1.2% of the asymptomatic patients...
  73. ncbi Clustering of risk factors increases the incidence of echolucent carotid plaque in stroke patients
    Kazuo Yamashiro
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Cerebrovasc Dis 22:432-8. 2006
    ..The purpose of this study was to assess the influence of clusters of risk factors on the incidence of echolucent carotid plaque in stroke patients...
  74. ncbi Distal protection in cardiovascular medicine: current status
    Onn Akbar Ali
    Cardiology Department, Concord Repatriation General Hospital and ANZAC Research Institute, University of Sydney, Concord, Sydney, NSW, Australia
    Am Heart J 152:207-16. 2006
    ....
  75. ncbi Is the ABCD score useful for risk stratification of patients with acute transient ischemic attack?
    Brett L Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 37:1710-4. 2006
    ..This score incorporates age (A), blood pressure (B), clinical features (C), and duration (D) of TIA. A score <4 reportedly indicates minimal short-term stroke risk. We evaluated this scoring system in an independent population...
  76. ncbi Reduced frequency of embolic signals in severe carotid stenosis with poststenotic flow velocity reduction
    Michael Goertler
    Department of Neurology, University of Magdeburg, Magdeburg, Germany
    Cerebrovasc Dis 19:229-33. 2005
    ..We aimed to investigate the effect of poststenotic low blood flow in patients with recently symptomatic severe carotid stenosis on arterio-arterial embolism...
  77. ncbi Silent ischemia after neuroprotected percutaneous carotid stenting: a diffusion-weighted MRI study
    P Piñero
    Section of Neuroradiology, Hospitales Universitarios Virgen del Rocio, 41013 Seville, Spain
    AJNR Am J Neuroradiol 27:1338-45. 2006
    ....
  78. ncbi Patient selection for revascularization in cervical carotid artery disease: angioplasty and stenting vs. endarterectomy
    Mark R Harrigan
    Department of Neurosurgery and Toshiba Stroke Research Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14209, USA
    Am Heart Hosp J 2:8-15. 2004
    ....
  79. ncbi Dual cerebral protection technique during carotid stenting
    Zoran V Milosevic
    Department for Neuroradiology, Clinical Radiology Institute, University Clinical Centre Ljubljana, Slovenia
    J Endovasc Ther 14:86-90. 2007
    ..To present a technique for internal carotid artery stenting (CAS) with dual cerebral protection in patients with high-grade stenosis caused by large, soft atherosclerotic plaques...
  80. ncbi Ischaemic stroke in Jordan: a 2-year hospital-based study of subtypes and risk factors
    Y Bahou
    Department of Internal Medicine, Division of Neurology, Jordan University, Amman, Jordan
    East Mediterr Health J 10:138-46. 2004
    ..The favourable outcome (85% discharged home) may be due to the relatively young age and the predominance of lacunar infarcts...
  81. ncbi Carotid artery stenting using distal embolic protection device
    Nadir Khan
    Department ofDiagnostic Imaging, Brown Medical School, USA
    Med Health R I 88:96. 2005
  82. ncbi Vessel wall damage caused by cerebral protection devices: ex vivo evaluation in porcine carotid arteries
    Stefan Muller-Hulsbeck
    Department of Radiology, University Hospital Schleswig Holstein Campus Kiel, Arnold Heller Strasse 9, 24105 Kiel, Germany
    Radiology 235:454-60. 2005
    ..To determine the extent of vessel wall damage caused by cerebral protection devices designed for carotid angioplasty by using ex vivo porcine carotid arteries...
  83. ncbi Carotid artery stenting: update
    Robert S Dieter
    Washington Hospital Center Georgtown University, USA
    Int J Cardiovasc Intervent 7:126-33. 2005
    ..This update reviews the technical aspects of carotid artery stenting, clinical data supporting carotid artery stenting-particularly in high risk patients, and the complications associated with carotid artery stenting."..
  84. ncbi Tandem balloon protection during emergency carotid artery stenting of a stenotic ICA lesion with intraluminal thrombus
    Keisuke Imai
    Department of Emergency Medicine, Acute Stroke Center, Kyoto First Red Cross Hospital, Higashiyama, Kyoto, Japan
    J Endovasc Ther 14:214-8. 2007
    ..To report a technique for emergency CAS of a stenotic internal carotid artery (ICA) lesion with an intraluminal thrombus, which predisposes to distal thromboembolism and could aggravate pre-existing neurological symptoms...
  85. ncbi Brain injury secondary to carotid intervention
    Sumaira Macdonald
    Freeman Hospital, Newcastle upon Tyne, UK
    J Endovasc Ther 14:219-31. 2007
    ....
  86. ncbi Impaired clearance of microemboli and cerebrovascular symptoms during carotid stenting procedures
    Giovanni Orlandi
    Department of Neuroscience, University of Pisa, Pisa, Italy
    Arch Neurol 62:1208-11. 2005
    ..Transcranial Doppler monitoring shows a high prevalence of microemboli during carotid artery stenting (CAS); however, the occurrence of cerebrovascular symptoms (CVSs) does not seem to be related to the microembolic load...
  87. ncbi Transcervical approach with protective flow reversal for carotid angioplasty and stenting
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3280, USA
    J Endovasc Ther 12:446-53. 2005
    ..To report our initial experience using a transcervical approach for carotid angioplasty/stenting (CAS) that employs internal carotid artery (ICA) flow reversal for neuroprotection...
  88. ncbi Protection filter-related events in extracranial carotid artery stenting: a single-center experience
    Bae Ju Kwon
    Department of Radiology, Seoul National University College of Medicine, 28 Yongon Dong, Seoul 110 744, Korea
    J Endovasc Ther 13:711-22. 2006
    ..To report the complications, rescue procedures, and consequences related to the use of an embolus protection filter during carotid artery stenting (CAS)...
  89. ncbi Embolism to the brain during carotid stenting and surgery
    B Gossetti
    La Sapienza University of Rome, Italy
    Acta Chir Belg 107:151-4. 2007
    ....
  90. ncbi Techniques for carotid artery stenting under cerebral protection
    C J Schonholz
    Heart and Vascular Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Cardiovasc Surg (Torino) 46:201-17. 2005
    ..Several clinical series in which cerebral protection was employed have also been described. Each type of protection device has advantages and disadvantages, which are discussed in this review...
  91. ncbi [Angioplasty and stenting of extracranial cerebral vessels]
    I Petrov
    Khirurgiia (Sofiia) 59:5-16. 2003
    ..Stenting of a vertebral artery as the unique brain supplying vessel and 4. Stenting of subocclusive aortoostial lesion of the brachiocephalic trunk in a patient with totally occluded contralateral internal carotid artery...
  92. ncbi Impact of diabetes, patient age, and gender on the 30-day incidence of stroke and death in patients undergoing carotid artery stenting with embolus protection: a post-hoc subanalysis of a prospective multicenter registry
    Michael Schlüter
    Hamburg University Cardiovascular Center, Hamburg, Germany
    J Endovasc Ther 14:271-8. 2007
    ..To assess the impact of diabetes, patient age, and gender on major periprocedural (30-day) complications (major and minor strokes, all-cause deaths) following carotid artery stenting (CAS)...
  93. ncbi Clot removal therapy by aspiration and extraction for acute embolic carotid occlusion
    K Imai
    Department of Stroke Treatment, Shonan Kamakura General Hospital, 1201 1 Yamazaki Kamakura, Kanagawa 247 8533, Japan
    AJNR Am J Neuroradiol 27:1521-7. 2006
    ..The purpose of our retrospective study was to investigate the feasibility, safety, and efficacy of clot removal therapy by aspiration and extraction for patients with acute stroke with embolic internal carotid artery (ICA) occlusion...
  94. ncbi Carotid angioplasty under cerebral protection with the PercuSurge GuardWire System
    Michel Henry
    Cabinet de Cardiologie, Nancy, France
    Catheter Cardiovasc Interv 61:293-305. 2004
    ..Protection devices seem indispensable to perform CAS and expand the applicability of the procedure. Randomized studies (surgery vs. CAS with and without cerebral protection) are awaited...
  95. ncbi Percutaneous interventions in patients with acute ischemic stroke related to obstructive atherosclerotic disease or dissection of the extracranial carotid artery
    Dimitrios Nikas
    Department of Cardiology, Mirano General Hospital, Mirano, Italy
    J Endovasc Ther 14:279-88. 2007
    ..To determine the safety, feasibility, and efficacy of carotid artery stenting (CAS) in patients with acute stroke who underwent angioplasty of the extracranial internal carotid artery (ICA)...
  96. ncbi A new concept for covered stent protected carotid angioplasty: an ex vivo study
    S Muller-Hulsbeck
    Department of Radiology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Rofo 175:1634-8. 2003
    ..To determine the efficacy of a covered stent prototype designed for protected carotid angioplasty to reduce cerebral embolization...
  97. ncbi Preventable complications of carotid stenting
    Mark K Eskandari
    Division of Vascular Surgery and Department of Radiology, Northwestern Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Perspect Vasc Surg Endovasc Ther 20:17-25. 2008
    ..The primary objective of this review is to provide a heightened awareness of both anticipated and unanticipated risks of the procedure, with the hope of avoiding recurring problems...
  98. ncbi Transcervical carotid stenting with carotid artery flow reversal: 3-year follow-up of 103 stents
    Enrique Criado
    Section of Vascular Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 46:864-9. 2007
    ....
  99. ncbi Current status in cervical carotid artery stent placement
    M H Wholey
    Department of Cardiovascular and Interventional Radiology, University of Texas, Health Science Center at San Antonio, 78284, USA
    J Cardiovasc Surg (Torino) 44:331-9. 2003
    ..Carotid stenting will increase in application in the future especially among high surgical-risk patients with symptomatic and asymptomatic carotid occlusive disease...
  100. ncbi Flow impairment during protected carotid artery stenting: impact of filter device design
    Marco Roffi
    Andreas Gruntzig Cardiovascular Catheterization Laboratories, Department of Cardiology, University Hospital, Raemistrasse 100, Zurich, Switzerland
    J Endovasc Ther 15:103-9. 2008
    ..To investigate the impact of filter design on blood flow impairment in the internal carotid artery (ICA) among patients undergoing carotid artery stenting (CAS) using filter-type emboli protection devices (EPD)...
  101. ncbi [Plaque morphology of the carotid bifurcation and incidence of embolisms in relation clinical stage of cerebrovascular insufficiency]
    K Balzer
    Gefässchirurgische Klinik, Evangelisches Krankenhaus, Wertgasse 30, 45468 Mülheim an der Ruhr
    Kongressbd Dtsch Ges Chir Kongr 119:631-4. 2002
    ..In 127 patient an analysis of TC-Doppler curve was possible. During some operations (eversion endarteriectomie) we performed experimental stent implantation. The evaluation was performed with statistical methods...

Research Grants31

  1. AGING AND COGNITION AFTER CARDIAC SURGERY
    Mark Newman; Fiscal Year: 2003
    ..The new information regarding cerebral protection would also have application in all ischemic brain syndromes including stroke. ..
  2. Quality Improvement and Outcomes for Strokes After CABG
    DONALD LIKOSKY; Fiscal Year: 2004
    ..abstract_text> ..
  3. Aging, Vascular Disease and Cognition
    David Moser; Fiscal Year: 2007
    ..abstract_text> ..
  4. HARMONIC DOPPLER ULTRASOUND EMBOLUS CHARACTERIZATION
    MARK MOEHRING; Fiscal Year: 2006
    ..This work is anticipated to result in improved neurological outcomes in the targeted heart surgery application, and a Phase III partner is ready and waiting to take the technology to market. [unreadable] [unreadable]..
  5. Mechanisms of Radiation-Induced Cognitive Dysfunction
    William Brown; Fiscal Year: 2008
    ..Such therapeutic intervention studies could potentially be performed in as little as 10 weeks. ..
  6. Treatment of Acute Embolic Stroke with Statins and rt-PA
    Zheng Gang Zhang; Fiscal Year: 2009
    ....
  7. CNS antigen sensitization in stroke.
    Kyra Becker; Fiscal Year: 2009
    ..Data derived from this study will be used to plan future trials of immunomodulation in patients with stroke. ..
  8. Induced Hypertension for Acute Ischemic Stroke
    Robert Wityk; Fiscal Year: 2004
    ..An association of improved function, with reduction in the volume of mismatch, will support the proposed physiology. ..
  9. THE ROLE OF LYMPHOCYTES IN CEREBRAL ISCHEMIC INJURY
    Kyra Becker; Fiscal Year: 2004
    ....
  10. MRI AND RT PA TREATMENT OF EMBOLIC STROKE
    Quan Jiang; Fiscal Year: 2003
    ..The long-term goal is to provide new and important information relevant to the treatment of acute stroke by thrombolysis. ..
  11. RELATION BETWEEN ATTENTION AND LANGUAGE IN APHASIA
    Laura Murray; Fiscal Year: 2003
    ..abstract_text> ..
  12. Thrombophilia In Cryptogenic Stroke (THICK) Study
    JORGE KIZER; Fiscal Year: 2006
    ..Interactions among thrombophilias, thrombophilias and traditional cardiovascular risk factors, and thrombophilias and other potential cardiac sources of embolism will also be investigated. ..
  13. Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    William C Culp; Fiscal Year: 2010
    ..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..
  14. In vivo MR Evaluation of Cell Therapy for Stroke
    Quan Jiang; Fiscal Year: 2009
    ....
  15. Long-term White Matter Changes Resulting from Delirium after Surgery
    James Rudolph; Fiscal Year: 2008
    ..If the hypotheses are confirmed, this will alter our fundamental understanding of delirium as a short-term disorder and future studies can use imaging to prevent, identify, and treat delirium. [unreadable] [unreadable] [unreadable]..
  16. Diagnostic Utility of MRI in Intracerebral Hemorrhage
    CHRISTINE A WIJMAN; Fiscal Year: 2010
    ..We anticipate that the findings from this study will have a major impact on the management of ICH patients and will facilitate the development of practice guidelines for the use of MRI in these patients. ..
  17. Doppler Ultrasound Automatic Mapping of Basal Cerebral Blood Flow
    MARK MOEHRING; Fiscal Year: 2006
    ..A device for automatic location of and fast mapping, tracking, and monitoring of blood flow in the basal arteries of the brain represents a major commercial market potential. [unreadable] [unreadable]..
  18. TCD Post-Resuscitation Blood Flow & Edema Monitor
    MARK MOEHRING; Fiscal Year: 2006
    ..Further, we anticipate this device will be more sensitive to the early stages of reperfusion injury that lead to acute adverse outcomes. ..
  19. REDUCING SPINAL CORD INJURY WITH RETROGRADE PERFUSION
    John Kern; Fiscal Year: 2004
    ..Basic research is needed, however, before applying this technique clinically. ..
  20. Pharmacogenetics and Antithrombotic Therapy
    Brian Gage; Fiscal Year: 2003
    ..Using high performance liquid chromatography, we will measure the levels of the 2 enantiomers of warfarin and test Hypothesis 4: Clearance of S-warfarin will be significantly decreased in the presence of 2C9 SNPs. ..
  21. Radiance 2100 AG-2Q Confocal Multiphoton System
    Zheng Gang Zhang; Fiscal Year: 2005
    ..abstract_text> ..
  22. Estradiol For Neurocognitive Dysfunction After CABG
    Charles Hogue; Fiscal Year: 2005
    ..The results of this study will evaluate the efficacy and safety of an easily implemented therapy for improving neurologic outcome and quality of life after CABG surgery for postmenopausal women. ..
  23. Cerebro/peripheral vascular function in cognition
    David Moser; Fiscal Year: 2005
    ..The proposed research is expected to yield publishable results and will also provide valuable pilot data for larger scale (e.g. R01) grant applications. ..
  24. VEGF and Angiopoietin 1 Therapy for Stroke
    Zheng Gang Zhang; Fiscal Year: 2006
    ..abstract_text> ..
  25. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..
  26. Improved Animal Modeling of Saccular Aneurysms
    David F Kallmes; Fiscal Year: 2010
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  27. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2008
    ..abstract_text> ..
  28. Genetic and Tissue Engineering for Aneurysms
    David Kallmes; Fiscal Year: 2004
    ..Successful implementation of this research program will advance the field of genetic and tissue engineering and will improve the care of patients harboring life-threatening cerebral aneurysms. ..