cerebral infarction

Summary

Summary: The formation of an area of necrosis in the cerebrum caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).

Top Publications

  1. ncbi Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects
    Mervyn D I Vergouwen
    Department of Medicine, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 42:924-9. 2011
  2. ncbi Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke
    Javier R Caso
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense Madrid, 28040 Madrid, Spain
    Circulation 115:1599-608. 2007
  3. ncbi 1H-NMR-based metabolomics study of cerebral infarction
    Jee Youn Jung
    Korea Basic Science Institute, Seoul, 136 713, Korea
    Stroke 42:1282-8. 2011
  4. ncbi Progressive lacunar stroke: review of mechanisms, prognostic features, and putative treatments
    Alessandra Del Bene
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy
    Int J Stroke 7:321-9. 2012
  5. ncbi Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene
    C Iadecola
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 17:9157-64. 1997
  6. ncbi Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarction
    Nami Nakagomi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    Stem Cells 27:2185-95. 2009
  7. pmc Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction
    Jens H Jensen
    Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016 3295, USA
    NMR Biomed 24:452-7. 2011
  8. ncbi Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage
    R Webster Crowley
    Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA
    Stroke 42:919-23. 2011
  9. ncbi Cerebral small-vessel disease and decline in information processing speed, executive function and memory
    Niels D Prins
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 128:2034-41. 2005
  10. ncbi Incidence and short-term outcome of cerebral infarction in young adults in western Norway
    H Naess
    Department of Neurology, Haukeland Hospital, University of Bergen, Bergen, Norway
    Stroke 33:2105-8. 2002

Detail Information

Publications395 found, 100 shown here

  1. ncbi Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects
    Mervyn D I Vergouwen
    Department of Medicine, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 42:924-9. 2011
    ..Our aim was to clarify the relationship among angiographic vasospasm, neurological worsening, cerebral infarction, and poor outcome and to investigate whether cerebral infarction also contributes to poor outcome by ..
  2. ncbi Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke
    Javier R Caso
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense Madrid, 28040 Madrid, Spain
    Circulation 115:1599-608. 2007
    ..We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion of the middle cerebral artery differ in mice that lack a functional TLR4 signaling pathway...
  3. ncbi 1H-NMR-based metabolomics study of cerebral infarction
    Jee Youn Jung
    Korea Basic Science Institute, Seoul, 136 713, Korea
    Stroke 42:1282-8. 2011
    ..Thus, we applied a 1H-NMR metabolomics approach to investigate the altered metabolic pattern in plasma and urine from patients with cerebral infarctions and sought to identify metabolic biomarkers associated with stroke...
  4. ncbi Progressive lacunar stroke: review of mechanisms, prognostic features, and putative treatments
    Alessandra Del Bene
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy
    Int J Stroke 7:321-9. 2012
    ..Moreover, based on putative mechanisms and suggestions from reported evidence, we propose a few treatments that seem worthy to be tested by randomized clinical trials...
  5. ncbi Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene
    C Iadecola
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 17:9157-64. 1997
    ..iNOS inhibition may provide a novel therapeutic strategy targeted specifically at the secondary progression of ischemic brain injury...
  6. ncbi Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarction
    Nami Nakagomi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    Stem Cells 27:2185-95. 2009
    ..These data indicate that reconstitution of elements in the vascular niche enhances transplantation of adult neural progenitor cells...
  7. pmc Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction
    Jens H Jensen
    Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016 3295, USA
    NMR Biomed 24:452-7. 2011
    ..It is proposed that this effect is consistent with a large drop in the intra-axonal diffusivity, possibly related to either axonal varicosities or alterations associated with the endoplasmic reticulum...
  8. ncbi Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage
    R Webster Crowley
    Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA
    Stroke 42:919-23. 2011
    The long-standing concept that delayed cerebral infarction after aneurysmal subarachnoid hemorrhage results exclusively from large artery vasospasm recently has been challenged...
  9. ncbi Cerebral small-vessel disease and decline in information processing speed, executive function and memory
    Niels D Prins
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 128:2034-41. 2005
    ..Our results suggest that in older people cerebral small-vessel disease may contribute to cognitive decline by affecting information processing speed and executive function...
  10. ncbi Incidence and short-term outcome of cerebral infarction in young adults in western Norway
    H Naess
    Department of Neurology, Haukeland Hospital, University of Bergen, Bergen, Norway
    Stroke 33:2105-8. 2002
    We sought to determine the incidence and short-term outcome of people aged 15 to 49 years with first-ever cerebral infarction in 1988-1997 in Hordaland County, Norway.
  11. ncbi Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarction
    J M Schwab
    Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
    Neuropathol Appl Neurobiol 26:434-40. 2000
    ..study reports CTGF expression by cells associated with matrix deposition and glial scar formation in human cerebral infarction. CTGF was localized by immunohistochemistry in 17 brains of patients after focal infarction and in three ..
  12. ncbi Polymorphism of apolipoprotein A5 is a risk factor for cerebral infarction in type 2 diabetes
    Xuefeng Li
    Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China
    J Huazhong Univ Sci Technolog Med Sci 28:653-6. 2008
    ..investigated the association of apolipoprotein A5 (apoA5) gene polymorphism at position -1131T>C with cerebral infarction in patients with type 2 diabetes...
  13. ncbi Impairment of cerebral perfusion and infarct patterns attributable to vasospasm after aneurysmal subarachnoid hemorrhage: a prospective MRI and DSA study
    Stefan Weidauer
    Institute of Neuroradiology, University of Frankfurt, Frankfurt, Germany
    Stroke 38:1831-6. 2007
    ..The objective of this study was to investigate disturbance of perfusion and infarct patterns attributable to cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH)...
  14. ncbi Physical exercise induces expression of CD31 and facilitates neural function recovery in rats with focal cerebral infarction
    Xiquan Hu
    Department of Rehabilitation Medicine, Second Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, China
    Neurol Res 32:397-402. 2010
    ..The present study was aimed at examining the role of physical exercise in the improvement of damaged neural function and the induction of angiogenesis...
  15. ncbi Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction
    Shihui Xing
    Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Autophagy 8:63-76. 2012
    b>Cerebral infarction can cause secondary degeneration of thalamus and delay functional recovery. However, the mechanisms underlying secondary degeneration are unclear...
  16. ncbi Relative elevation in baseline leukocyte count predicts first cerebral infarction
    M S V Elkind
    Department of Neurology, Columbia University College of Physicians and Surgeons, Joseph Mailman School of Public Health, New York, NY, USA
    Neurology 64:2121-5. 2005
    ..Atherosclerosis is an inflammatory disease, and leukocyte levels are associated with future risk of ischemic cardiac disease...
  17. ncbi An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts
    Chintamani Narasinh Joshi
    Division of Toxicology, Central Drug Research Institute, Chattar Manzil, P O Box 173, Lucknow, UP 226 001, India
    Brain Res Brain Res Protoc 13:11-7. 2004
    ..05% TTC provided improved delineation of brain infarcts, reduced 'nonspecific' staining of white matter and the infarct size correlated well with that measured after 1% TTC staining; the method also reduces the costs to 1/20...
  18. ncbi Neuroprotection in cerebral infarction: the opportunity of new studies
    Natalia Perez de la Ossa
    Stroke Unit, Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
    Cerebrovasc Dis 24:153-6. 2007
    ..A better understanding of ischemic and restorative brain mechanisms beyond the acute phase of stroke may open new therapeutic options to improve stroke recovery...
  19. ncbi Non-linear association between ankle-brachial pressure index and prevalence of silent cerebral infarction in Japanese patients with type 2 diabetes
    Ryotaro Bouchi
    Division of Nephrology and Hypertension, Diabetes Center, Tokyo Women s Medical University School of Medicine, 8 1 Kawadacho, Shinjukuku, Tokyo 162 8666, Japan
    Atherosclerosis 222:490-4. 2012
    ..We aimed to reveal whether ABI abnormality, especially high ABI is associated with prevalent silent cerebral infarction (SCI) in type 2 diabetic patients.
  20. ncbi Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction
    Kazuo Yano
    Laboratory for Pharmacology, Asahi Kasei Pharma, Shizuoka, Japan
    Eur J Pharmacol 594:77-83. 2008
    Evidence that Rho-kinase is involved in cerebral infarction has accumulated. However, it is uncertain whether Rho-kinase is activated in the brain parenchyma in cerebral infarction...
  21. ncbi Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin
    Yun Xia Li
    The Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, China
    Neurosci Bull 24:89-95. 2008
    ..To investigate whether desferoxamine (DFO) preconditioning can induce tolerance against cerebral ischemia and its effect on the expression of hypoxia inducible factor 1alpha (HIF-1alpha) and erythropoietin (EPO) in vivo and in vitro...
  22. ncbi Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress
    Yukihito Higashi
    Hiroshima University, Graduate School of Biomedical Sciences, Department of Cardiovascular Physiology and Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Expert Opin Pharmacother 10:323-31. 2009
    ..therapeutic strategy for the prevention of brain injury and reduction of mortality in patients with acute cerebral infarction. A combination of established thrombolytic therapy and effective neuronal protection therapy has more ..
  23. ncbi Lactococcus garvieae endocarditis with initial presentation of acute cerebral infarction in a healthy immunocompetent man
    Wei Kai Li
    Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
    Intern Med 47:1143-6. 2008
    ..We present a case study of a 41-year-old man with infective endocarditis caused by L. garvieae which is the first reported case with initial presentation as acute cerebral infarction.
  24. ncbi Diffuse cerebral intravascular coagulation and cerebral infarction in pneumococcal meningitis
    Mervyn D I Vergouwen
    Department of Neurology, H2 259, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
    Neurocrit Care 13:217-27. 2010
    There is a widely held belief that cerebral infarction after bacterial meningitis is always caused by vasculitis; however, evidence is weak...
  25. ncbi Hypothermic protection in rat focal ischemia models: strain differences and relevance to "reperfusion injury"
    Yubo Ren
    Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Cereb Blood Flow Metab 24:42-53. 2004
    ....
  26. ncbi Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome
    Yoshiji Yamada
    FAHA, Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Mie 514 8507, Japan
    Int J Mol Med 21:801-8. 2008
    ..aim of the present study was to identify genetic variants that confer susceptibility to atherothrombotic cerebral infarction among individuals with metabolic syndrome in order to allow prediction of genetic risk for this condition...
  27. ncbi Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: the Rotterdam study
    M Hollander
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, and Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, The Netherlands
    Circulation 105:2872-7. 2002
    ..and limited data exist on the importance of location of plaques or the association with subtypes of cerebral infarction. We investigated the relationship between carotid plaques, measured at different locations, and risk of ..
  28. ncbi Predictors of cerebral infarction in aneurysmal subarachnoid hemorrhage
    Alejandro A Rabinstein
    Neurological Neurosurgical Intensive Care Unit and the Department of Neurology, Rochester, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Stroke 35:1862-6. 2004
    Clinical and radiologic predictors of cerebral infarction occurrence and location after aneurysmal subarachnoid hemorrhage have been seldom studied.
  29. ncbi Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus
    Tong Wang
    Molecular Biology Laboratory, Acupuncture and Moxibustion Research Institute, The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    Physiol Behav 96:155-61. 2009
    ..The result of the research suggested that acupuncture can exert antiapoptotic effect through counter-regulating Bcl-2 and Bax gene expression...
  30. ncbi Vascular syndromes of the thalamus
    Jeremy D Schmahmann
    Department of Neurology, VBK 915, Massachusetts General Hospital, Fruit St, Boston, MA 02114, USA
    Stroke 34:2264-78. 2003
    ..This article reviews the anatomy, connections, and functions of the thalamic nuclei, their vascular supply, and the clinical syndromes that result from thalamic infarction...
  31. pmc Cannabinoid CB(2) receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model
    Ming Zhang
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Cereb Blood Flow Metab 27:1387-96. 2007
    ..Administration of the selective CB(2) agonists significantly decreased cerebral infarction (30%) and improved motor function (P<0.05) after 1 h MCAO followed by 23 h reperfusion in mice...
  32. ncbi Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localised lesions
    Ysbrand D Van Der Werf
    Department of Anatomy and Embryology, Graduate School for Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Neuropsychologia 41:1330-44. 2003
    ..Separate thalamic structures are involved in memory, executive functioning and attention...
  33. ncbi Fatigue at long-term follow-up in young adults with cerebral infarction
    Halvor Naess
    Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway
    Cerebrovasc Dis 20:245-50. 2005
    ..To study the impact of fatigue in young ischaemic stroke patients...
  34. ncbi Patterns of cerebral infarction in aneurysmal subarachnoid hemorrhage
    Alejandro A Rabinstein
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Stroke 36:992-7. 2005
    ..The aim of this study was to analyze the distribution patterns of delayed cerebral ischemia after subarachnoid hemorrhage (SAH) and the factors that determine their occurrence...
  35. ncbi Specific caspase pathways are activated in the two stages of cerebral infarction
    A Benchoua
    , , , France
    J Neurosci 21:7127-34. 2001
    ..We show that in the early stages of cerebral infarction, neurons of the so-called "necrotic" core display a number of morphological, physiological, and ..
  36. ncbi Early hemicraniectomy in patients with complete middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1888-93. 1998
    ..Several reports indicate a beneficial effect of hemicraniectomy in this situation. However, whether and when decompressive surgery is indicated in these patients is still a matter of debate...
  37. ncbi Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study
    W T Longstreth
    Department of Neurology, University of Washington, Seattle, USA
    Arch Neurol 55:1217-25. 1998
    ..To identify risk factors for and functional consequences of lacunar infarct in elderly people...
  38. ncbi Cerebral infarction in eclampsia
    Gerda G Zeeman
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Am J Obstet Gynecol 190:714-20. 2004
    ..This study was undertaken to characterize the neuroimaging findings of cerebral edema associated with eclamptic seizures by use of diffusion-weighted magnetic resonance imaging (MRI)...
  39. ncbi Advanced glycation end products in patients with cerebral infarction
    Yuko Ohnuki
    Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan
    Intern Med 48:587-91. 2009
    ..In this study, we determined skin AGEs in patients with cerebral infarction.
  40. ncbi The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells
    Kiyoshi Kikuchi
    Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Science, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Pharmacol Exp Ther 329:865-74. 2009
    Edaravone, a potent free radical scavenger, is clinically used for the treatment of cerebral infarction in Japan...
  41. ncbi Risk factors for posttraumatic cerebral infarction in patients with moderate or severe head trauma
    Heng Li Tian
    Department of Neurosurgery, Shanghai Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Neurosurg Rev 31:431-6; discussion 436-7. 2008
    We examined the incidence and timing of posttraumatic cerebral infarction (PTCI) and provide predictive factors for the development of PTCI in patients with moderate or severe traumatic brain injury...
  42. ncbi TAFI polymorphisms at amino acids 147 and 325 are not risk factors for cerebral infarction
    Hiroyasu Akatsu
    Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441 8914, Japan
    Br J Haematol 127:440-7. 2004
    ..We investigated whether these TAFI polymorphisms would act as a risk factor for cerebral infarction (CI) by examining 253 samples in which the diagnosis was cliniconeuropathologically confirmed...
  43. ncbi Mouse model of in situ thromboembolic stroke and reperfusion
    Cyrille Orset
    INSERM Avenir tPA in the working brain, University of Caen, Centre Cyceron, Bd Becquerel, BP 5229, 14074 Caen Cedex, France
    Stroke 38:2771-8. 2007
    ..As such, one is forced to consider that new animal models of focal cerebral ischemia may be required before clinical evaluation of a new molecule...
  44. pmc An efficient framework for estimation of muscle fiber orientation using ultrasonography
    Shan Ling
    The Shenzhen Key Laboratory for Low cost Healthcare, Shenzhen, China
    Biomed Eng Online 12:98. 2013
    ..The traditional manual method for MFO estimation in sonograms was labor-intensive. The automatic methods proposed in recent years also involved voting procedures which were computationally expensive...
  45. ncbi Impact of systemic inflammatory response syndrome on vasospasm, cerebral infarction, and outcome after subarachnoid hemorrhage: exploratory analysis of CONSCIOUS-1 database
    Alan K H Tam
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Neurocrit Care 13:182-9. 2010
    ..associated with SIRS after SAH, whether SIRS was associated with complications of SAH such as vasospasm, cerebral infarction, and clinical outcome, and whether SIRS could contribute to a difference in outcome between patients ..
  46. ncbi Increased oxidative stress is responsible for severer cerebral infarction in stroke-prone spontaneously hypertensive rats
    Xiu Hua Zhang
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China
    CNS Neurosci Ther 17:590-8. 2011
    To examine the role of increased oxidative stress in the pathogenesis of cerebral infarction in stroke in stroke-prone spontaneously hypertensive rats (SHR-SP).
  47. ncbi Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarction magnetic resonance imaging study
    Kai Lin
    Department of Radiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, and Beijing Anzhen Hospital, Anzhen Li, Chaoyang District, Beijing 100029, China
    Acad Radiol 13:1180-6. 2006
    ....
  48. ncbi The functional anatomy of single-word reading in patients with hemianopic and pure alexia
    A P Leff
    MRC Clinical Sciences Centre, Cyclotron Unit, Hammersmith Hospital, London W12 0NN, UK
    Brain 124:510-21. 2001
    ..The relative contributions of pure and hemianopic alexia in individual patients needs to be assessed, as the latter has been shown to respond well to specific rehabilitation programmes...
  49. pmc Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis
    Yu Yo Sun
    Division of Developmental Biology, Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, United States
    J Neurosci Methods 203:122-9. 2012
    A simple method to quantify cerebral infarction has great value for mechanistic and therapeutic studies in experimental stroke research...
  50. ncbi Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury
    P Zhang
    Department of Anesthesiology, Second Affiliated Hospital of Xi an Jiaotong University School of Medicine, 157 West 5 road, Xi an, Shaanxi 710004, China
    Neuroscience 201:297-306. 2012
    Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction. However, its effect on stroke-induced subventricular zone (SVZ) neurogenesis is largely unknown...
  51. ncbi Imaging corticospinal degeneration in neonatal rats with unilateral cerebral infarction
    S Lama
    Medical Science, Faculty of Medicine, University of Calgary
    Exp Neurol 228:192-9. 2011
    ..This demonstrates directly the utility of ADC and T(2) MRI to detect acute changes in axons associated with early Wallerian degeneration...
  52. ncbi Electroacupuncture enhances motor recovery performance with brain-derived neurotrophic factor expression in rats with cerebral infarction
    Min Wook Kim
    Institute of Catholic Integrative Medicine, Incheon St Mary s Hospital, Catholic University, Seoul, Korea
    Acupunct Med 30:222-6. 2012
    ..Brain-derived neurotrophic factor (BDNF) is a potent growth factor involved in recovery following cerebral injury. The aim of the present study was to investigate whether EA increases BDNF levels and facilitates functional recovery...
  53. ncbi Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
    K Murakami
    CNS Injury and Edema Research Center, Department of Neurological Surgery, University of California, School of Medicine, San Francisco, California 94143 0651, USA
    J Neurosci 18:205-13. 1998
    ..The present study suggests that O2- overproduced in a mitochondrial compartment, when uncoupled from antioxidant defenses, induces impairment of mitochondrial function and causes exacerbation of cerebral infarction after ischemia.
  54. ncbi Transneuronal retrograde degeneration of the retinal ganglion cells in patients with cerebral infarction
    Hae Young Lopilly Park
    Department of Ophthalmology and Visual Science, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Ophthalmology 120:1292-9. 2013
    ..In addition, whether laterality and severity of retinal nerve fiber layer (RNFL) damage correlated with 3 other variables was determined: laterality of hemispheric damage, arterial territory of infarct, and age of infarct...
  55. ncbi Effects of transcranial direct current stimulation on hemichannel pannexin-1 and neural plasticity in rat model of cerebral infarction
    T Jiang
    Department of Neurology, the Third Affiliated Hospital of Southern Medical University, NO 183, Zhongshan Road West, Guangzhou 510630, China
    Neuroscience 226:421-6. 2012
    ..0001). Cerebral infarction induced increased PX1 mRNA expression on days 3, 7, and 14 (P<0...
  56. ncbi Red blood cell distribution width is associated with poor clinical outcome in acute cerebral infarction
    Jinkwon Kim
    Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
    Thromb Haemost 108:349-56. 2012
    ..We investigated whether RDW in acute cerebral infarction is predictive of functional outcome and mortality...
  57. ncbi Association of extracellular superoxide dismutase gene with cerebral infarction in women: a haplotype-based case-control study
    Takahiro Naganuma
    Division of Molecular Diagnostics, Department Advanced Medical Science, Nihon University School of Medicine, Tokyo, Japan
    Hereditas 145:283-92. 2008
    It has been reported that oxidative stress is a factor in cerebral infarction (CI)...
  58. ncbi Dietary pattern, nutritional density, and dietary quality were low in patients with cerebral infarction in Korea
    Hyunjung Lim
    Department of Medical Nutrition, Graduate School of East West Medical Science, Kyung Hee University, Yongin, Republic of Korea
    Nutr Res 31:601-7. 2011
    The aim of this study was to examine if the dietary quality of patients with cerebral infarction (CI) was comparatively worse than those of non-CI subjects in Korea...
  59. pmc Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Firenze, Italy
    BMJ 339:b2477. 2009
    ..To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these changes...
  60. ncbi Cerebral infarction associated with acute subarachnoid hemorrhage
    J Michael Schmidt
    Neurological Intensive Care Unit, Division of Stroke and Critical Care, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurocrit Care 7:10-7. 2007
    b>Cerebral infarction is a common complication of aneurysmal subarachnoid hemorrhage (SAH), but usually occurs several days after onset as a complication of vasospasm or aneurysm repair...
  61. ncbi Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats
    B Lei
    Department of Anesthesiology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Neuroscience 125:691-701. 2004
    ..These findings suggest that lidocaine attenuates apoptosis in the penumbra after transient focal cerebral ischemia. The infarct-reducing effects of lidocaine may be due, in part, to the inhibition of apoptotic cell death in the penumbra...
  62. ncbi Decompressive craniectomy in massive cerebral infarction
    João Paulo Mattos
    Neurosurgery Department, UNICAMP, Campinas SP, Brazil
    Arq Neuropsiquiatr 68:339-45. 2010
    ..Dominant hemispheric infarction does not represent exclusion criteria...
  63. ncbi Wavelet analysis of cerebral oxygenation signal measured by near infrared spectroscopy in subjects with cerebral infarction
    Zengyong Li
    School of Mechanical Engineering, Shandong University, Jinan, PR China
    Microvasc Res 80:142-7. 2010
    The objective of this study is to assess the cerebral oxygenation oscillations in subjects with cerebral infarction (CI) based on the wavelet transform of near infrared spectroscopy (NIRS) signals...
  64. ncbi Effect of large dose hyperbaric oxygenation therapy on prognosis and oxidative stress of acute permanent cerebral ischemic stroke in rats
    Lianbi Xue
    Department of Hyperbaric Oxygenation, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Neurol Res 30:389-93. 2008
    ..To evaluate the therapeutic effect and the oxidative stress effect of 9 and 18 hour hyperbaric oxygenation therapy (HBOT) protocols on the earliest stage of acute permanent middle cerebral artery occlusion (MCAO) in rats...
  65. ncbi Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats
    Jing Liu
    Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China
    Brain Res 1089:162-70. 2006
    ..Our results demonstrated that PF could attenuate cognitive deficit and brain damage induced by chronic cerebral hypoperfusion and that suppression of neuroinflammatory reaction in brain might be involved in PF-induced neuroprotection...
  66. ncbi In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice
    Ning Liu
    Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1397:66-75. 2011
    ....
  67. pmc Neuroprotection of tanshinone IIA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats
    Yanlin Chen
    Department of Pathology, Chongqing Medical University, Chongqing, People s Republic of China
    PLoS ONE 7:e40165. 2012
    ..However, little is known about the underlying mechanisms. Here we put forward the hypothesis that TSA acts through inhibition of MIF expression during focal cerebral I/R injury in rats...
  68. ncbi Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats
    Sharon Hom
    Dept of Pharmacology, College of Medicine, Univ of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1881-92. 2007
    ..tight-junction (TJ) and ion transporter proteins critical for maintaining brain homeostasis contribute to cerebral infarction during hypertension development...
  69. ncbi Plasma miR-124 as a biomarker for cerebral infarction
    Huachun Weng
    Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Biomed Res 32:135-41. 2011
    ..We examined whether plasma concentrations of brain-specific miRNA can serve as a biomarker for cerebral infarction, where the cerebral infarction was modeled by middle cerebral artery occlusion (MCAO) in the rat...
  70. ncbi Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats
    S H Fang
    Department of Pharmacology, School of Medicine, Zhejiang University, 353 Yanan Road, Hangzhou 310031, China
    Neuroscience 140:969-79. 2006
    ..Thus, we conclude that cysteinyl leukotriene receptor 1 mediates acute neuronal damage and subacute/chronic astrogliosis after focal cerebral ischemia...
  71. ncbi Evaluation of admission characteristics, hospital length of stay and costs for cerebral infarction in a medium-sized city in China
    Y Ma
    Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong Department of Forensic Medicine, North Sichuan Medical College, Nanchong, P R China
    Eur J Neurol 17:1270-6. 2010
    ..This study aimed to evaluate hospital length of stay (LOS) by admission characteristics and costs correlated with medical insurance status for cerebral infarction in a medium-sized city in China.
  72. ncbi Functional recovery and expression of GDNF seen in photochemically induced cerebral infarction
    Keisuke Horinouchi
    Department of Rehabilitation and Physical Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Int J Neurosci 117:315-26. 2007
    ..However, there have been few reports examining the relationship between GDNF and functional recovery after cerebral infarction. The authors investigated the change in the expression of GDNF proteins during functional recovery in rats ..
  73. ncbi Mild depression in young adults with cerebral infarction at long-term follow-up: a population-based study
    H Naess
    Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway
    Eur J Neurol 12:194-8. 2005
    ..for post-stroke depression (PSD) at long-term follow-up in young adults aged 15-49 years with first-ever cerebral infarction in a population-based study...
  74. pmc Association of transforming growth factor-β1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese: a case-control study
    Zhongxing Peng
    Institute of Neurosciences, The Second Affiliated Hospital of Guangzhou Medical College, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Guangzhou 510260, P R China
    Lipids Health Dis 10:100. 2011
    ..study was carried out to investigate the possible association of the TGF-β1 gene C-509T and T869C polymorphisms, and their combined genotypes with the risk of atherosclerotic cerebral infarction (CI) in the Chinese population.
  75. ncbi Predictors for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis
    Futoshi Anan
    Department of Cardiology, Oita Red Cross Hospital, Oita, Japan
    Metabolism 56:593-8. 2007
    ..89; 95% confidence interval, 1.57-3.38; P < .005). Our findings indicate that HGF may be a novel useful predictor of SCI in patients with chronic renal failure undergoing HD...
  76. ncbi Alzheimer's disease with and without cerebral infarcts
    Teodoro Del Ser
    Seccion de Neurologia, Hospital Severo Ochoa, Avda Orellana s n, Leganes, 28911 Madrid, Spain
    J Neurol Sci 231:3-11. 2005
    ..To compare the clinical and pathological features of Alzheimer's disease (AD) patients with and without associated cerebral infarcts (CI)...
  77. ncbi Reduction of cerebral infarction in rats by biliverdin associated with amelioration of oxidative stress
    Kentaro Deguchi
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Okayama, Japan
    Brain Res 1188:1-8. 2008
    ..b>Cerebral infarction was induced by transient middle cerebral artery occlusion (tMCAO) for 90 min, followed by reperfusion...
  78. pmc Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death
    Thiruma V Arumugam
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:14104-9. 2007
    ..Our data suggest a major role for complement-mediated cell death in ischemic brain injury and the prospect of using IVIG in relatively low doses as an interventional therapy for stroke...
  79. ncbi Carotid plaque composition and cerebral infarction: MR imaging study
    Mohamed Ouhlous
    Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    AJNR Am J Neuroradiol 26:1044-9. 2005
    ..We analyzed the relationship between the composition of the atherosclerotic plaque at the carotid artery bifurcation and ipsilateral ischemic cerebral lesions on MR imaging...
  80. pmc Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhage
    Mervyn D I Vergouwen
    Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 31:1545-53. 2011
    ..It has been suggested that cerebral infarction is a better outcome measure than vasospasm in clinical trials and observational studies...
  81. ncbi Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system
    Qiang Wang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Stroke 40:2157-64. 2009
    ..The present study was aimed to investigate the involvement of the endocannabinoid system in the early neuroprotection conferred by EA pretreatment in the animal model of focal cerebral ischemia...
  82. ncbi Shift of motor activation areas during recovery from hemiparesis after cerebral infarction: a longitudinal study with near-infrared spectroscopy
    Kotaro Takeda
    Department of Neurology, International University of Health and Welfare Hospital, 537 3 Iguchi, Nasushiobara 329 2763, Japan
    Neurosci Res 59:136-44. 2007
    ..24) as motor function recovered. These findings suggest that a transient increase in motor activation in the ipsilateral intact hemisphere within 1 month may play an important role in the recovery from motor dysfunction after stroke...
  83. ncbi Cerebral infarction in autopsies of chagasic patients with heart failure
    Roque Aras
    Universidade Federal da Bahia, Salvador, BA, Brazil
    Arq Bras Cardiol 81:414-6, 411-3. 2003
    ..To determine the frequency of encephalic infarction and its contribution to lethality in patients with Chagas' disease and heart failure...
  84. ncbi Long-term outcome of cerebral infarction in young adults
    H Naess
    Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway
    Acta Neurol Scand 110:107-12. 2004
    We analysed the long-term outcome of 232 young adults aged 15-49 years with first-ever cerebral infarction in 1988-1997 in western Norway.
  85. ncbi Proposal for a universal definition of cerebral infarction
    Jeffrey L Saver
    Stroke Center and the Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Stroke 39:3110-5. 2008
    b>Cerebral infarction is a leading cause of disability and death worldwide but has no uniform international definition.
  86. ncbi Predictors of cerebral infarction in patients with aneurysmal subarachnoid hemorrhage
    Sherise Fergusen
    Section of Neurosurgery, Department of Surgery, The University of Chicago Medical Center, Pritzker School of Medicine, Chicago, Illinois, USA
    Neurosurgery 60:658-67; discussion 667. 2007
    b>Cerebral infarction would be expected to be associated with poor outcome after aneurysmal subarachnoid hemorrhage (SAH), although there are few data on which to base this assumption...
  87. ncbi Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
    Kenichi Mishima
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka City, Fukuoka, Japan
    Stroke 36:1077-82. 2005
    ..Cannabidiol has been reported to be a neuroprotectant, but the neuroprotective mechanism of cannabidiol remains unclear. We studied the neuroprotective mechanism of cannabidiol in 4-hour middle cerebral artery (MCA) occlusion mice...
  88. pmc Relationship between carotid intima-media thickness and silent cerebral infarction in Japanese subjects with type 2 diabetes
    Kazuhiro Nomura
    Center for Diabetes and Endocrinology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
    Diabetes Care 33:168-70. 2010
    We examined the relationship between intima-media thickness of common carotid artery (CCA-IMT) and silent cerebral infarction (SCI) with the magnetic resonance imaging (MRI) study in Japanese subjects with type 2 diabetes.
  89. ncbi Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals
    Gyung W Kim
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, Calif, USA
    Stroke 33:809-15. 2002
    ....
  90. ncbi The effect of electro-acupuncture on motor function recovery in patients with acute cerebral infarction: a randomly controlled trial
    J Pei
    Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032
    J Tradit Chin Med 21:270-2. 2001
    The aim of this study is to investigate the effect of electro-acupuncture treatment in acute phase of cerebral infarction on the motor functions...
  91. ncbi Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction
    Qing wu Yang
    Department of Neurology, Daping Hospital, The Third Military Medical University, Yuzhong District, Chongqing, China
    J Cereb Blood Flow Metab 28:1588-96. 2008
    ..mice, 6 h of cerebral ischemia followed by 24 h of reperfusion did not significantly change cerebral edema, cerebral infarction area, and neurologic impairment scores in MyD88 gene knockout mice...
  92. pmc Silent infarcts in young children with sickle cell disease
    Janet L Kwiatkowski
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Br J Haematol 146:300-5. 2009
    ..The prevalence of silent infarcts in young children with SCD-SS is similar to that of older children and anaemia and severe vasculopathy may be risk factors...
  93. ncbi The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?
    Dwaine F Emerich
    Life Sciences Research and Development, Alkermes, Cambridge, Massachusetts 02139, USA
    Exp Neurol 173:168-81. 2002
    ..For this reason we also offer suggestions for additional experiments and the inclusion of control groups that, in the future, might provide more effective or conclusive tests of the hypothesis...
  94. ncbi Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarction
    Yumi Shimo-Nakanishi
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Atherosclerosis 175:109-15. 2004
    ..We investigated the association between p22(phox) C242T polymorphism and thrombotic cerebral infarction and the role of this polymorphism on superoxide-production activity in human neutrophils and promyelocytic ..
  95. ncbi Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat
    Zhong Pei
    University Department of Medicine, Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Neurosci Lett 318:141-4. 2002
    ..2, 51.2 and 44.5%, respectively. Melatonin did not affect the hemodynamic parameters. Thus, pre-treatment with melatonin at a dose between 5 and 50 mg/kg protects against focal cerebral ischemia without reperfusion...
  96. ncbi Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury
    Jun Li
    Center for Cardiovascular Research Institute of Pharmacology and Toxicology, Charite University Medicine Berlin, Germany
    FASEB J 19:617-9. 2005
    ..Our data indicate that cerebral AT2 receptors exert neuroprotective actions in response to ischemia-induced neuronal injury, possibly by supporting neuronal survival and neurite outgrowth in peri-ischemic brain areas...
  97. ncbi Meta-analysis of association between variation in the PDE4D gene and ischemic cerebral infarction risk in Asian populations
    Xiaowei Xu
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Neurogenetics 11:327-33. 2010
    ..22; 95% CI, 1.03-1.43) and SNP 83 CC genotype (OR, 1.42; 95% CI, 1.14-1.77), but not for SNP 83 CC + CT genotypes or SNP 87. PDE4D was associated with ischemic infarction risk in Asian people, and SNP 83 was an important biomarker...
  98. ncbi Neuropsychology of infarctions in the thalamus: a review
    Y D Van Der Werf
    Graduate School for Neurosciences, Amsterdam, The Netherlands
    Neuropsychologia 38:613-27. 2000
    ..The results indicate that damage to the mediodorsal nucleus of the thalamus, the midline nuclei or the intralaminar nuclei, or a combined lesion of these structures may be responsible for deficits of executive functioning...
  99. ncbi The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats
    Nou Ying Tang
    China Medical University, Taichung, Taiwan
    Am J Chin Med 38:51-64. 2010
    ..The ratios of cerebral infarction area to total brain area, and neuro-deficit score were used as an index to observe the effects of ..
  100. ncbi Endogenous neurogenesis in the human brain following cerebral infarction
    Stephen L Minger
    Stem Cell Biology Laboratory, Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Regen Med 2:69-74. 2007
    ....
  101. ncbi Incidental findings on brain MRI in the general population
    Meike W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 357:1821-8. 2007
    ..We conducted a study to determine the prevalence of such incidental brain findings in the general population...

Research Grants62

  1. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..In support of our hypothesis, D609 (a) significantly reduced cerebral infarction at reperfusion days 1 and 3, (b) up-regulated p21 and p27 through ceramide accumulation, and (c) attenuated ..
  2. Reperfusion and Neurovascular Injury in Stroke
    Pak H Chan; Fiscal Year: 2013
    ..to metalloproteinase-9 (MMP-9) activation and BBB disruption that characterize neurovascular injury and cerebral infarction. We have recently discovered that signal transducer and activator of transcription 3 (STAT3) is a ..
  3. Treatment of stroke with a clinically approved proteasome inhibitor
    Li Zhang; Fiscal Year: 2012
    ..a proteasome inhibitor, VELCADE, an agent in clinical use for the treatment of cancer, effectively reduces cerebral infarction, and concomitantly reduces secondary thrombosis and microvascular permeability in young rats...
  4. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..nitrite inhalation on absolute CBF during and after filament MCAO and measure amount of tissue at risk for cerebral infarction as a function of the fraction of inspired oxygen (Fi02), 2) Define ethyl nitrite efficacy in a long-term ..
  5. Development of New Molecular Probes for Diagnostic Imaging of Atherosclerosis
    KAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010
    ..Cardiovascular disease remains the primary cause of mortality in the United States with myocardial and cerebral infarction caused by atherosclerosis accounting for these deaths...
  6. The role of a novel AIF-associated nuclease PAAN1 in neuronal injury
    Yingfei Wang; Fiscal Year: 2013
    ..Poly(ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in glutamate neurotoxicity and cerebral infarction, which is a primary cause of subsequent morbidity and mortality following stroke...
  7. Poly (ADP-Ribose) and AIF in Neuronal Injury
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2013
    ..Poly(ADP-ribose) polymerase-1 (PARP-1) is pivotal in glutamate neurotoxicity and cerebral infarction. Prior studies indicate that NO, or peroxynitrite plays a prominent role in glutamate excitotoxicity and ..
  8. MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIA
    Gregory J del Zoppo; Fiscal Year: 2010
    ..cathepsin and heparanase activities decreases matrix HSPG and HS degradation, and reduces the volume of cerebral infarction. Studies of the contributions of HSPG/HS-degrading proteases to the loss of microvessel integrity and ..
  9. Cerebral arteriole structure/function in diabetic ischemic brain injury
    Adviye Ergul; Fiscal Year: 2013
    ..due to preexisting diabetes or acute stress response is associated with higher incidence and severity of cerebral infarction, edema formation and the risk of hemorrhagic transformation (HT) that develops secondary to AIS ..
  10. Integrative Genomics of Stroke
    Rose Du; Fiscal Year: 2013
    ..In this proposal, we aim to study the susceptibility to cerebral infarction in the presence of focal cerebral ischemia in mice via an integrative strain survey...
  11. Pharmacogenomic studies in VISP: results &implications for clinical trial design
    Bradford B Worrall; Fiscal Year: 2011
    ..to determine whether the daily intake of high dose folic acid, vitamins B6 and B12 reduced recurrent cerebral infarction and a combined vascular endpoint...
  12. Neuroglobin in Neuronal Hypoxi and Cerebral Ischemia
    DAVID ALAN GREENBERG; Fiscal Year: 2013
    ..in vitro and ischemic cerebral injury in vivo, and that Ngb-overexpressing transgenic mice are resistant to cerebral infarction from occlusion of the middle cerebral artery...
  13. Culprit Plaque in Acute Cerebral Infarction: A Histological and MRI Assessment
    Thomas Hatsukami; Fiscal Year: 2013
    ....
  14. NEUROPROTECTIVE EFFECT OF HEAT STRESS IN CORTICAL NEURON
    BARBARA SNIDER; Fiscal Year: 1999
    b>Cerebral infarction remains a significant cause of morbidity and mortality, with limited treatment options available...
  15. COCAINE AND PERINATAL CEREBRAL AND UMBILICAL VESSELS
    Michael Schreiber; Fiscal Year: 1992
    ..Complications include intracranial hemorrhage, cerebral infarction, microcephaly, and seizures...
  16. Jun Kinase Signaling and Apoptosis in Ischemia Stroke
    Chia Yi Kuan; Fiscal Year: 2006
    ..for apoptosis induced by ischemia-hypoxia and whether the inhibition of JNK3 signaling protects against cerebral infarction. We will test the role of the constitutively active JNK1 isoform in global ischemia and the stress-induced ..
  17. STROKE PREVENTION TRIAL IN SICKLE CELL ANEMIA
    Donald Brambilla; Fiscal Year: 2000
    ..TCD) ultrasound which can detect arterial abnormalities which place these children at high risk for cerebral infarction. Prediction is based on the detection of high arterial blood flow rates which are associated with arterial ..
  18. STROKE PREVENTION TRIAL IN SICKLE CELL ANEMIA (STOP)
    Robert Adams; Fiscal Year: 2000
    ..TCD) ultrasound which can detect arterial abnormalities which place these children at high risk for cerebral infarction. Prediction is based on the detection of high arterial blood flow rates which are associated with arterial ..
  19. Rheolytic Thrombectomy for Treatment of Ischemic Stroke
    Cindy Setum; Fiscal Year: 2001
    ..S. The majority of strokes are caused by cerebral infarction due to acute thrombus and arterial occlusion...
  20. COGNITIVE AND NEUROIMAGING STUDY OF SICKLE CELL ANEMIA
    Elias Melhem; Fiscal Year: 2001
    ..to neuropsychological impairment seen in children with Sickle Cell Disease (SCD) who have no evidence of cerebral infarction on conventional Magnetic Resonance Imaging (MRI)...
  21. EPIDEMIOLOGIC STUDY OF STROKE OUTCOME IN 3 ETHNIC GROUPS
    Ralph Sacco; Fiscal Year: 1999
    ..2 of Healthy People 2000. The aims of this revised competitive continuation are to compare outcomes after cerebral infarction among white (non-Hispanic), black (non-Hispanic) and Hispanic men and women residents of northern Manhattan,..
  22. Genetic Markers of Thrombosis in Embolic Stroke
    Karen Furie; Fiscal Year: 2006
    ..Thus, it is imperative that markers of stroke risk be developed for this particular mechanism of cerebral infarction. In order to identify markers of embolic stroke risk, it is logical to focus on the hemostatic system, ..
  23. HUMAN ALBUMIN THERAPY-TREATMENT OF ACUTE ISCHEMIC STROKE
    MYRON GINSBERG; Fiscal Year: 2003
    ..the safely tolerated maximum dose and administration of intravenous HSAlb in patients with acute ischemic cerebral infarction of 8 hours' duration or less; and to implement standardized procedures for monitoring cardiovascular ..
  24. AMYLOID ANGIOPATHY, EARLY PLAQUES & AGING
    Blas Frangione; Fiscal Year: 2003
    ..an important role in the pathogenesis of Alzheimer's disease since a combination of Alzheimer's disease and cerebral infarction is the second commonest type of dementia...
  25. PATHOPHYSIOLOGY OF THROMBOEMBOLIC STROKE
    W Dietrich; Fiscal Year: 2003
    ..Recent experimental data indicate that a prior thromboembolic event is a risk factor for I widespread cerebral infarction and hemorrhage when combined with a dalayed ischemic insult...
  26. RANDOMIZED STUDY OF NICARDIPINE IN SAH
    Neal Kassell; Fiscal Year: 1992
    ..Outcome measures will include neurological and disability status and cerebral infarction rate at three months following subarachnid hemorrhage and the occurrence of symptomatic vasospasm during ..
  27. HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTS
    SHARI WALDSTEIN; Fiscal Year: 2002
    DESCRIPTION: Hypertension is a major risk factor for cerebral infarction, intracranial hemorrhage, and vascular dementia, particularly among older adults...
  28. HLA AS A PREDICTOR FOR STROKE IN SICKLE CELL ANEMIA
    Lori Styles; Fiscal Year: 2001
    ..cell anemia is the most common cause of stroke in childhood and 25% of children with SCA have evidence of cerebral infarction on MRI scanning...
  29. ANTIICAM-1 AND RTPA TREATMENT OF EMBOLIC STROKE
    Michael Chopp; Fiscal Year: 2002
    ..The fundamental outcome measurements of the combination therapy will be volume of cerebral infarction and net hemorrhage...
  30. MECHANISMS OF ACTION OF IL 1 IN ISCHEMIC BRAIN
    Guo Yuan Yang; Fiscal Year: 1999
    ..The parameters of brain injury to be monitored include edema, cerebral infarction volume, cerebral blood flow, blood brain barrier permeability, and changes in pathology using methods of ..
  31. Focal Brain Ischemia in the TNF-alpha-Transgenic Rat
    L Pettigrew; Fiscal Year: 2007
    ..secreted by astroglia, macrophages, and other cells participating in the inflammatory reaction initiated by cerebral infarction. Levels of TNFalpha rise sequentially in the infarct core, the ischemic penumbra, and in unaffected tissue ..
  32. Chlamydia Infection as a Risk Factor for Cerebrovascula*
    Lori Styles; Fiscal Year: 2004
    ..Our preliminary data indicates that SCA patients with MRI-documented cerebral infarction are 12 times more likely to have C. pneumoniae infection than SCA patients with normal MRI scans...
  33. PHYSIOLOGY OF NERVE, GLIAL AND MUSCLE CELL LINES
    David Schubert; Fiscal Year: 2005
    ..In CNS pathologies such as localized cerebral infarction some neurons die rapidly by necrosis while others die more slowly by a programmed cell death pathway ..
  34. IN VIVO MRI QUANTIFICATION OF TISSUE PERMEABILITY
    Harold Kundel; Fiscal Year: 2001
    ..nervous system including primary and secondary neoplasia, infection (HIV), vascular disorders (aneurysms), cerebral infarction and white matter disease (multiple sclerosis)...
  35. Etiology of cellular damage after experimental stroke
    Jaroslaw Aronowski; Fiscal Year: 2005
    ..proposed are largely based upon preliminary data linking cellular death to NF-kappaB activation after cerebral infarction and hemorrhage, and our recent finding of involvement of a novel enzyme in the NF-kappaB regulatory pathway,..
  36. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ..reperfusion injury in the postischemic brain, including a significantly higher incidence and severity of cerebral infarction and edema formation...
  37. STROKE OUTCOME PREDICTION--CLINICAL/DIAGNOSTIC IMPACT
    Marcella Wozniak; Fiscal Year: 1999
    ..to develop a multivariable predictor of 30 day and l year survival and stroke recurrence for patients with cerebral infarction. These predictors will be validated using data to be collected from the ongoing Maryland Stroke Data Bank (..
  38. COGNITIVE CHANGE IN CEREBROVASCULAR DISEASE
    John Morris; Fiscal Year: 2000
    ..cerebral hemodynamics in ischemic stroke" (NS 28947; RL Grubb, PI) will provide patients at high risk for cerebral infarction (carotid occlusion patients) after completion of their neurological and cerebral hemodynamic assessments...
  39. AMP-KINASE CASCADE ACTIVATORS AND ATHEROGENESIS
    J Foulkes; Fiscal Year: 1992
    DESCRIPTION (Adapted from Applicant's Abstract):Myocardial and cerebral infarction, conditions which are primarily the result of atherosclerotic lesions within coronary and cerebral blood vessels, are the leading causes of death in ..
  40. Protection from Stroke by SF/HGF-like Small Molecule
    Prakash Narayan; Fiscal Year: 2004
    Atherosclerosis of the cerebral vasculature can produce occlusion and cerebral infarction. Although the tissue in the ischemia core dies within minutes, the surrounding tissue, termed the ischemic penumbra, sustains damage from ..
  41. Murine Cardiovascular MRI
    Robert Weiss; Fiscal Year: 2003
    ..b>Cerebral infarction and microvascular function will be imaged in mice with diabetes and atherosclerosis...
  42. AFRICAN AMERICAN ANTIPLATELET STROKE PREVENTION STUDY
    Philip Gorelick; Fiscal Year: 2004
    ..Patients are enrolled no more than 90 days after incident cerebral infarction and are followed for 2 years. The investigators have already recruited 1400 of the needed 1800 subjects. Dr...
  43. PATHOLOGIC SEQUELAE OF INCOMPLETE CEREBRAL ISCHEMIA
    Robert Dempsey; Fiscal Year: 1990
    ..In this way a foundation for further studies of the evolution of cerebral infarction may be developed and the potential for slowing this process by inhibiting the contribution of harmful ..
  44. PLASMALOGENASE AND WHITE MATTER INJURY
    LLOYD HORROCKS; Fiscal Year: 1980
    ..The gerbil model for cerebral infarction will be used...
  45. NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS
    Wilmer Sibbitt; Fiscal Year: 2000
    ..Major NPSLE is characterized by seizures, psychosis, movement disorder, cerebral infarction, cognitive dysfunction, or death...
  46. EFFECT OF SPINAL CORD STIMULATION ON CEREBRAL BLOOD FLOW
    Oren Sagher; Fiscal Year: 2004
    ..We will also examine the feasibility of using SCS in the prevention of cerebral infarction. Specifically, we will test the following central hypotheses: I...
  47. Quality of Life Children With Sickle Cell Disease
    Julie Panepinto; Fiscal Year: 2009
    ..overt stroke will be examined and compared to the health-related QOL of those with silent stroke and no cerebral infarction. The impact of family factors on the health-related QOL of the child will be determined...
  48. Exacerbation of Atherosclerosis
    Guangming Zhong; Fiscal Year: 2004
    ..by the applicant): Atherosclerosis is the principal contributor to the pathogenesis of myocardial and cerebral infarction, and no effective treatment is yet available for atherosclerosis...
  49. Treatment of Hyperglycemia Ischemic Stroke(THIS)Trial
    Askiel Bruno; Fiscal Year: 2004
    ..Additional measurements will include vital signs, serum electrolytes, hemoglobin A-1C, and a global test for multiple clinical outcomes at 3 months. ..
  50. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  51. BODY REPRESENTATIONS--NEUROPSYCHOLOGY AND ANATOMIC BASIS
    H Coslett; Fiscal Year: 2001
    ..The potential clinical significance of this work is also clear. If, as hypothesized, the body schema is crucial to action, interventions targeting this representations may have important therapeutic implications. ..
  52. SPATIAL INFLUENCES ON LANGUAGE FUNCTION
    H Coslett; Fiscal Year: 2002
    ..abstract_text> ..
  53. Motor Imagery as a Measure of Pain Severity
    H Coslett; Fiscal Year: 2007
    ..Finally, as mental motor imagery tasks require minimal language capacity or abstract reasoning, we propose to investigate the use of these measures in subjects with cognitive impairment. ..
  54. The cognitive neuroscience of body knowledge
    H Coslett; Fiscal Year: 2007
    ..Understanding the cerebral basis of motor control and the body schema is likely to contribute substantially to the development of interventions that target these representations. [unreadable] [unreadable]..
  55. MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORS
    Raj Kalaria; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. Neurobiologic Study of Psychological Distress & Dementia
    Robert S Wilson; Fiscal Year: 2010
    ..g., tau positive tangles, cerebral infarction)...
  57. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..of potential mechanisms underlying migraine aura and linking migraine with both clinical and subclinical cerebral infarction. Third, it could help to identify the subpopulation of patients at risk of progressive cerebral ischemia so ..
  58. Cognitive neuroscience of temporal processing
    H Branch Coslett; Fiscal Year: 2010
    ..Finally, we propose to use transcranial magnetic stimulation to identify specific brain regions that are necessary for normal temporal processing. ..