Genomes and Genes
Summary: A sudden, nonconvulsive loss of neurologic function due to an ischemic or hemorrhagic intracranial vascular event. In general, cerebrovascular accidents are classified by anatomic location in the brain, vascular distribution, etiology, age of the affected individual, and hemorrhagic vs. nonhemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Publications318 found, 100 shown here
- European Stroke Initiative Recommendations for Stroke Management-update 2003Tom Skyhoj Olsen
Cerebrovasc Dis 16:311-37. 2003..The recommendations are endorsed by the 3 European societies which are represented in the European Stroke Initiative: the European Stroke Council, the European Neurological Society and the European Federation of Neurological Societies...
- An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosisHedley C A Emsley
University of Manchester, Manchester, UK
J Neuroimmunol 139:93-101. 2003....
- The influence of early aerobic training on the functional capacity in patients with cerebrovascular accident at the subacute stageMichal Katz-Leurer
Rehabilitation Department, Hadassah University Hospital, Jerusalem, Israel
Arch Phys Med Rehabil 84:1609-14. 2003To investigate the effect of early aerobic training on the aerobic and functional abilities of patients in the subacute stage of cerebrovascular accident (CVA).
- Thrombolysis for acute stroke in routine clinical practiceDawn M Bravata
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8025, USA
Arch Intern Med 162:1994-2001. 2002....
- Evidence for an association between air pollution and daily stroke admissions in Kaohsiung, TaiwanShang Shyue Tsai
Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Stroke 34:2612-6. 2003..This study was undertaken to determine whether there is an association between air pollution and hospital admissions for stroke in Kaohsiung, Taiwan...
- Long-term disability after first-ever stroke and related prognostic factors in the Perth Community Stroke Study, 1989-1990Graeme J Hankey
Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Western Australia
Stroke 33:1034-40. 2002..This population-based study aimed to describe disability, dependency, and related independent prognostic factors at 5 years after a first-ever stroke in patients in Perth, Western Australia...
- Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke modelPaula M Hughes
Nervous System Research, Core Technology Area, Novartis Pharma AG, Basel, Switzerland
J Cereb Blood Flow Metab 22:308-17. 2002..The results of this study indicate that inhibition of MCP-1 signaling could be a new acute treatment approach to limit infarct size after stroke...
- Dynamic cerebral autoregulation and beat to beat blood pressure control are impaired in acute ischaemic strokeP J Eames
Division of Medicine for the Elderly, University of Leicester, Glenfield Hospital, Groby Road, Leicester, UK
J Neurol Neurosurg Psychiatry 72:467-72. 2002..This study assessed whether dCA is compromised after acute stroke using spontaneous blood pressure (BP) changes as the stimulus for the dCA response...
- Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patientsMax Wintermark
Department of Diagnostic and Interventional Radiology, CHUV, Lausanne, Switzerland
Ann Neurol 51:417-32. 2002..It may also provide information about the extent of the penumbra. Perfusion CT could therefore be a valuable tool in the early management of acute stroke patients...
- A randomized controlled trial of early supported discharge and continued rehabilitation at home after stroke: five-year follow-up of patient outcomeAnn Mari Thorsén
Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden
Stroke 36:297-303. 2005..This study sought to evaluate the effect of early supported discharge and continued rehabilitation at home (ESD), in terms of patient outcome 5 years after stroke and changes in selected data over time...
- Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th centuryValery L Feigin
Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
Lancet Neurol 2:43-53. 2003....
- Stroke patients with atrial fibrillation have a worse prognosis than patients without: data from the Austrian Stroke registryChristina Steger
II Med Department, Krankenanstalt Rudolfstiftung, Vienna, Austria
Eur Heart J 25:1734-40. 2004..Whether stroke patients with AF also have a higher rate of medical complications is unknown. The aim of the study was to compare the in-hospital course of acute stroke patients with and without AF...
- Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke StudyL P Kammersgaard
Department of Neurology, University Hospital Gentofte, Copenhagen, Denmark
Stroke 33:1759-62. 2002..In the present study, we investigated the predictive role of admission body temperature to the long-term mortality in stroke patients...
- Long term cost-of-illness in stroke: an international reviewKrista A Payne
Caro Research Institute, Montreal, Quebec, Canada
Pharmacoeconomics 20:813-25. 2002..and Spanish literature was searched using the keywords stroke, ischaemic stroke, haemorrhagic stroke, cerebrovascular accident, cerebral infarction, cost(s), economics, and cost analysis...
- Excess stroke in Mexican Americans compared with non-Hispanic Whites: the Brain Attack Surveillance in Corpus Christi ProjectLewis B Morgenstern
Stroke Program, University of Michigan Medical School, Ann Arbor, MI 48109 0316, USA
Am J Epidemiol 160:376-83. 2004..As the Mexican-American population grows and ages, measures to target this population for stroke prevention are critical...
- Sex differences in US mortality rates for stroke and stroke subtypes by race/ethnicity and age, 1995-1998Carma Ayala
Cardiovascular Health Branch, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
Stroke 33:1197-201. 2002..Age-standardized death rates from overall stroke are higher among men than women, but little is known about sex differences in stroke subtype mortality by race/ethnicity...
- Older stroke patients in Europe: stroke care and determinants of outcomeA Bhalla
Department of Public Health Sciences, GKT School of Medicine, London, UK
Age Ageing 33:618-24. 2004..in order to implement cost-effective stroke services for older patients, it is necessary to identify how stroke care is currently provided for these patients and how provision relates to outcome...
- Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trialsWerner Hacke
Medical University at Heidelberg, Germany
Lancet 363:768-74. 2004..Quick administration of intravenous recombinant tissue plasminogen activator (rt-PA) after stroke improved outcomes in previous trials. We aimed to analyse combined data for individual patients to confirm the importance of rapid treatment...
- A systematic review of barriers to delivery of thrombolysis for acute strokeJoseph Kwan
University Department of Geriatric Medicine, Level E MP807, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Age Ageing 33:116-21. 2004..Barriers within the patient pathway can prevent early administration of thrombolytic therapy in patients admitted with acute stroke. This systematic review aimed to identify such barriers that have been reported in the medical literature...
- Is the association of National Institutes of Health Stroke Scale scores and acute magnetic resonance imaging stroke volume equal for patients with right- and left-hemisphere ischemic stroke?John N Fink
Beth Israel Deaconess Medical Center, Boston, Mass, USA
Stroke 33:954-8. 2002..The aim of this study was to investigate whether the relationship between acute NIHSS score and acute stroke volume as determined by acute diffusion- and perfusion-weighted MRI (DWI and PWI) differs between right- and left-sided stroke...
- Air pollution: a new risk factor in ischemic stroke mortalityYun Chul Hong
Department of Occupational and Environmental Medicine, Inha University College of Medicine, Jung Gu, Incheon, Korea
Stroke 33:2165-9. 2002..We investigated the association between acute stroke mortality and air pollution over a 7-year period (January 1991 through December 1997) in Seoul, Korea...
- Neuroprotection in cerebral ischaemia: facts and fancies--the need for new approachesNils Gunnar Wahlgren
Stroke Research Unit, Department of Neurology, Karolinska Hospital, Stockholm, Sweden
Cerebrovasc Dis 17:153-66. 2004..This article will summarize neuroprotection trials to date, some facts and fancies about neuroprotection, ischaemic pathophysiology and possible reasons for the apparent failure of human neuroprotective stroke trials...
- Incidence of cerebral hemorrhage in the Changsha community. A prospective study from 1986 to 2000Qi Dong Yang
Department of Neuroepidemiology, Institute of Neurology, The Xiangya Hospital, Central South University, Changsha, People s Republic of China
Cerebrovasc Dis 17:303-13. 2004..To provide information for preventing and managing ICH, we undertook this study supervising and determining the annual first-ever average incidence of cerebral hemorrhage from 1986 to 2000 in Changsha...
- Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomisPeter S Sever
Imperial College, London, UK
Lancet 361:1149-58. 2003..No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemic...
- Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic strokeJenny Crinion
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
Brain 128:2858-71. 2005..In addition, they highlight the importance of the right anterior superior temporal cortex where the response was dissociated from that in the left posterior temporal lobe...
- Blood pressure and clinical outcomes in the International Stroke TrialJo Leonardi-Bee
Centre for Vascular Research, University of Nottingham, Nottingham, UK
Stroke 33:1315-20. 2002....
- Evaluating the genetic component of ischemic stroke subtypes: a family history studyPaula Jerrard-Dunne
Department of Clinical Neurosciences, St George s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK
Stroke 34:1364-9. 2003..We determined the familial aggregation of stroke risk in different stroke phenotypes and used the results to model estimated sample size requirements for case-control studies...
- Decreased frequencies of ABCA1 polymorphisms R219K and V771M in Hungarian patients with cerebrovascular and cardiovascular diseasesHajnalka Andrikovics
Department of Molecular Genetics, National Medical Center, Budapest, Hungary
Cerebrovasc Dis 21:254-9. 2006..Genetic polymorphisms in ABC transporter A1 (ABCA1) may alter the regulation of plasma high-density lipoprotein (HDL), promoting or protecting from vascular diseases...
- Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multicenter magnetic resonance imaging studySusanne Wegener
Department of Neurology, University Hospital Charite, Schumannstrasse 20 21, 10117 Berlin, Germany
Stroke 35:616-21. 2004..We investigated whether transient ischemic attacks (TIAs) before stroke can induce tolerance by raising the threshold of tissue vulnerability in the human brain...
- Elevated plasma homocysteine in acute stroke was not associated with severity and outcome: stronger association with small artery diseaseF Perini
Headache and Stroke Center, Department of Neurology, St Bortolo Hospital, ULSS 6, Vicenza, Italy
Neurol Sci 26:310-8. 2005..Elevated plasma homocysteine in the acute phase of stroke was associated with both ischaemic and haemorrhagic stroke. Higher levels are associated with higher risk of small artery disease subtype of stroke...
- Short-term, intermediate-term, and long-term mortality in patients hospitalized for strokeTracie C Collins
Houston Center for Quality Care and Utilization Studies, 2002 Holcombe Blvd 152, Houston, TX 77030, USA
J Clin Epidemiol 56:81-7. 2003..Further work is needed to assess the impact of actual care patterns, for the above identified risk factors, on stroke prognosis over varying time periods...
- Stroke research in ChinaGangzhi Wei
Department of Neurology, Xuanwu Hospital, The Capital University of Medical Sciences, Beijing 100053, China
Neurol Res 28:11-5. 2006....
- Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trialK W Muir
Lancet 363:439-45. 2004..We aimed to test whether intravenous magnesium sulphate, given within 12 h of stroke onset, reduces death or disability at 90 days...
- Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicineRuediger Hilker
Department of Neurology, University Hospital, Cologne, Germany
Stroke 34:975-81. 2003..Pneumonia has been estimated to occur in about one third of patients after acute stroke. Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs)...
- Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam StudyHok Hay S Oei
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
Circulation 111:570-5. 2005..In the present study, we investigated whether Lp-PLA2 is an independent predictor of coronary heart disease and ischemic stroke...
- High-dose atorvastatin after stroke or transient ischemic attackPierre Amarenco
Denis Diderot University, Paris
N Engl J Med 355:549-59. 2006..Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established...
- Multicenter comparison of processes of care between Stroke Units and conventional care wards in AustraliaDominique A Cadilhac
National Stroke Research Institute, Level 1 Neurosciences Building, Repatriation Hospital, 300 Waterdale Road, Heidelberg Heights, Victoria, Australia 3081
Stroke 35:1035-40. 2004..Reasons may include greater adherence to processes of care (PoC). The primary hypothesis was that adherence to selected PoC is greater in SUs than in other acute care models...
- Statins induce angiogenesis, neurogenesis, and synaptogenesis after strokeJieli Chen
Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
Ann Neurol 53:743-51. 2003..Atorvastatin also induced phosphorylation of Akt and Erk in cultured primary cortical neurons. These data indicate that atorvastatin induced brain plasticity and has neurorestorative activity after experimental stroke...
- Short- and long-term prognosis for very old stroke patients. The Copenhagen Stroke StudyLars Peter Kammersgaard
Stroke Unit, Hvidovre University Hospital, Copenhagen, Denmark
Age Ageing 33:149-54. 2004..The aims of this study were to evaluate clinical characteristics of patients aged 85 years or more at stroke onset and to investigate very old age as an independent predictor of short- and long-term outcome...
- Early impairment in consciousness predicts mortality after hemispheric ischemic strokeBrett L Cucchiara
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA
Crit Care Med 32:241-5. 2004..Early predictors of poor outcome after acute ischemic stroke may be useful in selecting patients for potentially beneficial but high-risk interventions...
- A longitudinal fMRI study: in recovering and then in clinically stable sub-cortical stroke patientsDavid Tombari
INSERM U455, Pavillon Riser, Hopital Purpan, 31059 Toulouse, France
Neuroimage 23:827-39. 2004....
- Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemiaCarolina M Maier
Department of Neurosurgery, University School of Medicine, Stanford, Calif 94305 5487, USA
Stroke 35:1169-74. 2004..Here we examined the spatial-temporal relation between MMP-9 expression and neutrophil infiltration after stroke...
- Early outcome of carotid angioplasty and stenting with and without cerebral protection devices: a systematic review of the literatureAndreas Kastrup
Department of Neurology, University of Tubingen, Tubingen, Germany
Stroke 34:813-9. 2003....
- Blood pressure and vessel recanalization in the first hours after ischemic strokeHeinrich P Mattle
Department of Neurology, University of Berne, Freiburgstrasse, Inselspital, CH 3010 Berne, Switzerland
Stroke 36:264-8. 2005..Transient elevation of arterial blood pressure (BP) is frequent in acute ischemic stroke and may help to increase perfusion of tissue jeopardized by ischemia. If this is true, recanalization may eliminate the need for this BP elevation...
- Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059A Richard Green
AstraZeneca R and D Charnwood, Bakewell Road, Loughborough, Leics LE11 5RH, UK
Pharmacol Ther 100:195-214. 2003..NXY-059 may thus be the first compound to be examined in stroke patients using drug exposure and time to treatment that have been shown to be effective in animal models of stroke...
- Calcium channel blockade to prevent stroke in hypertension: a meta-analysis of 13 studies with 103,793 subjectsFabio Angeli
Departments of Cardiovascular Disease and Internal Medicine, Hospital R Silvestrini, Perugia, Italy
Am J Hypertens 17:817-22. 2004..We undertook a meta-analysis to assess whether calcium channel blockers (CCBs) are associated with a lesser risk of stroke as compared with other antihypertensive drugs...
- A comparison of rate control and rhythm control in patients with atrial fibrillationD G Wyse
AFFIRM Clinical Trial Center, Axio Research, 2601 4th Ave, Ste 200, Seattle, WA 98121, USA
N Engl J Med 347:1825-33. 2002..In both approaches, the use of anticoagulant drugs is recommended...
- Access to care, acculturation, and risk factors for stroke in Mexican Americans: the Brain Attack Surveillance in Corpus Christi (BASIC) projectMelinda A Smith
Stroke Program, University of Michigan Health System, Ann Arbor, USA
Stroke 34:2671-5. 2003..We compared access to care, acculturation, and biological risk factors among Mexican American and non-Hispanic white stroke patients and the general population...
- Utility of the NIH Stroke Scale as a predictor of hospital dispositionDaniel Schlegel
Department of Neurology, University of Pennsylvania, Philadelphia, USA
Stroke 34:134-7. 2003..The NIH Stroke Scale (NIHSS) is an attractive candidate predictor of disposition because it is widely used, is easily learned, and can be performed rapidly on admission...
- Thrombolytic therapy with recombinant tissue plasminogen activator for acute ischemic stroke: where do we go from here? A cumulative meta-analysisJ M Wardlaw
Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
Stroke 34:1437-42. 2003..Recombinant tissue plasminogen activator (rtPA; Actilyse) is not as widely used in clinical practice as it could be. Have new data since 1995 strengthened the evidence sufficiently to justify more widespread use of rtPA?..
- Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic coronary artery disease, and major adverse events at follow-upEmmanouil S Brilakis
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Eur Heart J 26:137-44. 2005..We aimed to evaluate the association of lipoprotein-associated phospholipase A2 (Lp-PLA2) with coronary artery disease (CAD) risk factors, with the severity of angiographic CAD, and with the incidence of major adverse events...
- Predictors of in-hospital mortality and attributable risks of death after ischemic stroke: the German Stroke Registers Study GroupPeter U Heuschmann
Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany
Arch Intern Med 164:1761-8. 2004..We investigated predictors for in-hospital mortality and attributable risks of death after ischemic stroke in a pooled analysis of large German stroke registers...
- Risk of hospitalized stroke in men enrolled in the Honolulu Heart Program and the Framingham Study: A comparison of incidence and risk factor effectsBeatriz L Rodriguez
Division of Clinical Epidemiology, John A Burns School of Medicine, University of Hawaii at Manoa, USA
Stroke 33:230-6. 2002..Our purpose was to compare the 20-year incidence of hospitalized stroke between Japanese-American men in the Honolulu Heart Program and white men in the Framingham Study...
- Effect of socioeconomic status on treatment and mortality after strokeMoira K Kapral
Institute for Clinical Evaluative Sciences, University Health Network University of Toronto, Ontario, Canada
Stroke 33:268-73. 2002..Socioeconomic status is associated with increased mortality from ischemic heart disease. We undertook a study to determine whether a similar association exists between socioeconomic status and stroke mortality...
- Improving delivery of acute stroke therapy: The TLL Temple Foundation Stroke ProjectLewis B Morgenstern
Stroke Program, Department of Neurology, University of Texas Medical School, Houston 77030, USA
Stroke 33:160-6. 2002..We performed a community and professional behavioral intervention project to increase the proportion of stroke patients treated with approved acute stroke therapy...
- Self-reported stress and risk of stroke: the Copenhagen City Heart StudyThomas Truelsen
Institute of Preventive Medicine, Kommune Hospitalet, Copenhagen K, Denmark
Stroke 34:856-62. 2003..To examine these possibilities, we analyzed the association between self-reported stress frequency and intensity and risk of stroke...
- Influence of somatosensory input on motor function in patients with chronic strokeAgnes Floel
Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
Ann Neurol 56:206-12. 2004....
- Carotid artery stenting is associated with increased complications in octogenarians: 30-day stroke and death rates in the CREST lead-in phaseRobert W Hobson
University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07101, USA
J Vasc Surg 40:1106-11. 2004..The occurrence of stroke and death was reviewed by an independent clinical events committee...
- Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric strokeStefan Schwarz
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 33:497-501. 2002..The purpose of this study was to prospectively evaluate the effects of body position in patients with large supratentorial stroke...
- Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trialJeffrey L Saver
UCLA Stroke Center, Geffen School of Medicine of the University of California, Los Angeles 90095, USA
Stroke 35:e106-8. 2004..To demonstrate that paramedic initiation of intravenous magnesium sulfate (Mg) in the field in focal stroke patients is feasible, safe, and yields significant time-savings compared with in-hospital initiation of neuroprotective therapy...
- The latest on functional imaging studies of aphasic strokeCathy J Price
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
Curr Opin Neurol 18:429-34. 2005..In this review of studies published between January 2004 and February 2005, we discuss imaging studies of speech production and comprehension in patients with aphasia after left hemisphere stroke...
- Incidence and trends of stroke and its subtypes in China: results from three large citiesBin Jiang
Department of Neuroepidemiology, Beijing Neurosurgical Institute, Beijing 100050, P R China
Stroke 37:63-8. 2006..To examine the incidence and trends of stroke and its major subtypes during the 1990s in 3 cities in China...
- The effect of pneumonia on mortality among patients hospitalized for acute strokeI L Katzan
Center for Health Care Research and Policy, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
Neurology 60:620-5. 2003..To determine the effect of pneumonia on 30-day mortality in patients hospitalized for acute stroke...
- Multiple levels of regulation of the interleukin-6 system in strokeDaniela Acalovschi
Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
Stroke 34:1864-9. 2003..The purpose of this study was to investigate whether serum levels of the receptor subunits are changed after ischemic stroke and to define the role of genetic influences on IL-6 expression in acute stroke...
- Analysis of fMRI and finger tracking training in subjects with chronic strokeJames R Carey
Program in Physical Therapy, University of Minnesota, Minneapolis 55455, USA
Brain 125:773-88. 2002..We concluded that individuals with chronic stroke receiving intensive tracking training showed improved tracking accuracy and grasp and release function, and that these improvements were accompanied by brain reorganization...
- Persisting consequences of stroke measured by the Stroke Impact ScaleSue Min Lai
Department of Preventive Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7313, USA
Stroke 33:1840-4. 2002....
- Tissue plasminogen activator for acute ischemic stroke in clinical practice: a meta-analysis of safety dataGlenn D Graham
Albuquerque VA and University of New Mexico School of Medicine, Department of Neurology, VA Medical Center, Albuquerque, NM 87122, USA
Stroke 34:2847-50. 2003..Numerous case series of clinical experience with tPA have been published that provide additional data on the safety of thrombolytic therapy...
- Emergency calls in acute strokeRene Handschu
Department of Neurology, Friedrich Alexander Universitaet, Erlangen Nurnberg, Erlangen, Germany
Stroke 34:1005-9. 2003..Subsequently, early recognition of stroke symptoms and rapid activation of the medical system are essential. We sought to investigate what witnesses or victims of an acute stroke syndrome recognize and report in the actual situation...
- Burden of first-ever ischemic stroke in the oldest old: evidence from a population-based studyC Marini
Clinica Neurologica, Universita degli Studi di L Aquila, Italy
Neurology 62:77-81. 2004..To evaluate the contribution of subjects 80 years old or older to the burden of ischemic stroke as compared with subjects younger than 80 years...
- Strengthening acute stroke trials through optimal use of disability end pointsFiona B Young
Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, Scotland
Stroke 34:2676-80. 2003..The Barthel Index (BI) and Rankin Scale (RS) have been widely used and analyzed in various ways. We sought to investigate the most powerful end point for use in acute stroke trials...
- The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and strokeAnna Helgadottir
deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
Nat Genet 36:233-9. 2004..We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall...
- A pilot randomized trial of induced blood pressure elevation: effects on function and focal perfusion in acute and subacute strokeA E Hillis
Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Cerebrovasc Dis 16:236-46. 2003..We conducted a pilot, randomized trial to evaluate effects of pharmacologically induced blood pressure elevation on function and perfusion in acute stroke...
- Family history in ischemic stroke before 70 years of age: the Sahlgrenska Academy Study on Ischemic StrokeKatarina Jood
Institute of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Sweden
Stroke 36:1383-7. 2005..Accordingly, we investigated stroke subtypes, vascular risk factors, and family history in a large study of patients with ischemic stroke onset before age 70 years...
- Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort studyShah Ebrahim
Department of Social Medicine, University of Bristol, Bristol BS8 2PR
BMJ 333:22. 2006..To investigate risk factors, such as heavy alcohol consumption, that might explain any increased risk of haemorrhagic stroke associated with low blood cholesterol...
- Stroke care delivery in institutions participating in the Registry of the Canadian Stroke NetworkMoira K Kapral
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Stroke 35:1756-62. 2004..Guidelines and performance indicators have been established for acute stroke care. However, little is known about the process of stroke care delivery in Canada...
- Validating administrative data in stroke researchDavid L Tirschwell
Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle 98104 2499, USA
Stroke 33:2465-70. 2002..Research based on administrative data has advantages, including large numbers, consistent data, and low cost. This study was designed to compare different methods of stroke classification using administrative data...
- Alcohol consumption and risk of stroke: a meta-analysisKristi Reynolds
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave SL18, New Orleans, LA 70112, USA
JAMA 289:579-88. 2003..Observational studies suggest that heavy alcohol consumption may increase the risk of stroke while moderate consumption may decrease the risk...
- Transient detection of early wallerian degeneration on diffusion-weighted MRI after an acute cerebrovascular accidentA Uchino
Department of Radiology, Saga Medical School, 5 1 1 Nabeshima, Saga, 849 8501, Japan
Neuroradiology 46:183-8. 2004We report three patients with a cerebrovascular accident studied serially by MRI, including diffusion-weighted imaging (DWI)...
- Potential confounding by intermediate phenotypes in studies of the genetics of ischaemic strokeEnrico Flossmann
Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford 0X2 6HE, UK
Cerebrovasc Dis 19:1-10. 2005..We studied FHx of ischaemic heart disease (IHD), hypertension (HTN) and diabetes mellitus (DM) as risk factors for ischaemic stroke...
- Association between diabetes and stroke subtype on survival and functional outcome 3 months after stroke: data from the European BIOMED Stroke ProjectSalah Eddine Megherbi
Stroke Registry of Dijon, Faculty of Medicine of Dijon, Burgundy University, Dijon, France
Stroke 34:688-94. 2003..We sought to evaluate stroke features, prognosis, and functional outcome in patients with diabetes compared with patients without diabetes...
- Magnetic resonance imaging findings of presumed cerebellar cerebrovascular accident in twelve dogsJ F McConnell
Animal Health Trust, Newmarket, Centre for Small Animal Studies, Suffolk CB8 7UU, UK
Vet Radiol Ultrasound 46:1-10. 2005The magnetic resonance imaging (MRI) findings of presumed cerebrovascular accident in 12 dogs are described. Fourteen lesions were seen, commonly (11 of 14) within the gray matter of the cerebellar hemispheres or vermis...
- Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcomeCraig J Smith
University of Manchester, Manchester M13 9PT, UK
BMC Neurol 4:2. 2004..We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome...
- The combined effect of paraoxonase promoter and coding region polymorphisms on the risk of arterial ischemic stroke among young adultsBarbara Voetsch
Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
Arch Neurol 61:351-6. 2004..Interindividual variability in PON1 levels is determined by the Q192R and L55M coding region polymorphisms and by 2 recently described polymorphisms in the promoter of the PON1 gene, C(-107)T and G(-824)A...
- Effects of introducing an integrated care pathway in an acute stroke unitJoseph Kwan
Western General Hospital, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
Age Ageing 33:362-7. 2004..We sought to evaluate the effects of introducing an integrated care pathway for acute stroke...
- Risk of ischemic stroke with tamoxifen treatment for breast cancer: a meta-analysisCheryl D Bushnell
Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
Neurology 63:1230-3. 2004..To assess the overall risk of stroke, specifically ischemic stroke, associated with tamoxifen use by performing a meta-analysis of data reported in breast cancer trials...
- Overt naming in aphasia studied with a functional MRI hemodynamic delay designPaula I Martin
Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine, MA 02130, USA
Neuroimage 28:194-204. 2005..This method permitted verification that the patients were cooperating with the task during fMRI. It has application for future fMRI studies of overt speech in aphasia...
- A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patientsH C A Emsley
Division of Neuroscience, The University of Liverpool, The Walton Centre for Neurology and Neurosurgery, Liverpool, UK
J Neurol Neurosurg Psychiatry 76:1366-72. 2005..We report here the first randomised, double blind, placebo controlled trial of recombinant human IL-1ra (rhIL-1ra) in patients with acute stroke...
- Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adultsBarbara Voetsch
Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
Stroke 33:1459-64. 2002..The association of these polymorphisms with the risk of AIS remains controversial...
- Posture control in Pusher syndrome: influence of lateral semicircular canalsTaiza Elaine Grespan dos Santos Pontelli
Braz J Otorhinolaryngol 71:448-52. 2005..The role of vestibular system on the pushing behavior is not clear...
- Therapeutic effects of suburothelial injection of botulinum a toxin for neurogenic detrusor overactivity due to chronic cerebrovascular accident and spinal cord lesionsHann Chorng Kuo
Department of Urology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
Urology 67:232-6. 2006To investigate the therapeutic effects of suburothelial botulinum A toxin for patients with chronic cerebrovascular accident (CVA) and spinal cord lesions...
- Community participation following cerebrovascular accident: impact of the buffering model of social supportMargaret Newsham Beckley
The Ohio State University, College of Medicine and Public Health, School of Allied Medical Professions, 453 West Tenth Avenue, Columbus, Ohio 43210, USA
Am J Occup Ther 60:129-35. 2006..The findings indicate that for people who had sustained a cerebrovascular accident, community participation was more related to their ability to do for themselves, rather than the support ..
- Reduction of spastic hypertonia during repeated passive knee movements in stroke patientsGodelieve E Nuyens
Department of Rehabilitation Sciences, Faculty of Physical Education and Physiotherapy, University of Leuven, Belgium
Arch Phys Med Rehabil 83:930-5. 2002..To quantify changes in spastic hypertonia during repeated passive isokinetic knee movements in stroke patients and to assess the role of muscle activity...
- The Siblings With Ischemic Stroke Study (SWISS): a progress reportJames F Meschia
Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
Clin Med Res 4:12-21. 2006..This report updates the progress of enrollment in the SWISS protocol, discusses barriers to pedigree completion and describes innovative approaches used by the SWISS investigators to enhance enrollment...
- Impact of early vs delayed admission to rehabilitation on functional outcomes in persons with strokeKatherine Salter
Department of Physical Medicine and Rehabilitation, Parkwood Hospital, St Joseph s Health Centre, London, Ontario, Canada
J Rehabil Med 38:113-7. 2006..The present study examined the effects of early vs delayed admission on functional outcome and length of stay in patients admitted to a rehabilitation unit for first-ever unilateral stroke...
- Cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction and cerebrovascular accidentN S Abraham
Houston Center for Quality of Care and Utilization Studies, and Deparment of Gastroenterology, Michael E DeBakey VAMC and Baylor College of Medicine, Houston, TX 77030, USA
Aliment Pharmacol Ther 25:913-24. 2007To assess degree of cyclooxygenase-2 (COX-2) selectivity of a non-steroidal anti-inflammatory drug (NSAID) and risk of myocardial infarction (MI) or cerebrovascular accident (CVA).
- Motor imagery: a backdoor to the motor system after stroke?Nikhil Sharma
Department of Clinical Neurosciences, University of Cambridge, England
Stroke 37:1941-52. 2006..Specifically, whether the primary motor cortex (M1), considered a prime target of poststroke rehabilitation, is involved in motor imagery is unresolved...
- Lifetime cost of stroke subtypes in Australia: findings from the North East Melbourne Stroke Incidence Study (NEMESIS)Helen M Dewey
National Stroke Research Institute, Level 1, Neurosciences Bldg, Repatriation Campus, Austin and Repatriation Medical Centre, 300 Waterdale Rd, Heidelberg Heights, Victoria 3081, Australia au
Stroke 34:2502-7. 2003..The purpose of this study was to describe the patterns of resource use and to estimate the first-year and lifetime costs for stroke subtypes...
- Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysisCarl van Walraven
Clinical Epidemiology Unit, Ottawa Health Research Institute, F 6, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, Ontario, Canada K1Y 4E9
JAMA 288:2441-8. 2002..Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and other vascular events...
- Ischemia-reperfusion-related repair deficit after oxidative stress: implications of faulty transcripts in neuronal sensitivity after brain injuryPhilip K Liu
Departments of Neurosurgery and Molecular and Cell Biology and Cardiovascular Disease Program of the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
J Biomed Sci 10:4-13. 2003..This suggests that the accuracy of gene expression could be accounted for the recovery of cellular function after cerebral injury...
- Serial changes in static and dynamic cerebral autoregulation after acute ischaemic strokeSuzanne L Dawson
University Division of Medicine for the Elderly, Leicester Warwick Medical School, University of Leicester, UK
Cerebrovasc Dis 16:69-75. 2003..The longitudinal changes in static and dynamic cerebral autoregulation (CA) following acute ischaemic stroke are unknown and were assessed in this study...
- Increased risk of heart disease and stroke among foreign-born females residing in the United StatesMaria Rubia
New School University, Milano Graduate School, New York, NY 10011, USA
Am J Prev Med 22:30-5. 2002..This article provides an update of mortality rates among the foreign born in the United States and, in particular, examines mortality rates from heart disease among foreign-born females...
- Human embryonic stem cell-derived neural crest stem cells and Hirschsprung diseaSean J Morrison; Fiscal Year: 2010..Nervous System Diseases/*therapy</keyword;keyword>Cerebrovascular Accident/therapy</keyword;keyword>Clinical Trials</keyword;keyword>Epilepsy/therapy</keyword;..
- Deacetylation of mitochondrial proteins protect neurons from ischemic injuryConrad Alano; Fiscal Year: 2013....
- Treatment of stroke with a clinically approved proteasome inhibitorLi Zhang; Fiscal Year: 2012..Therefore, in the current application, we propose to investigate the neuroprotective effects of VELCADE alone and incombination with tPA and the mechanisms underlying the beneficial effects in aged rats after embolic stroke. ..
- Homing of Stem Cells in Stroke TherapeuticsEVAN YALE contact SNYDER; Fiscal Year: 2010..hNSCs following peripheral administration 24 hrs post-stroke, particularly under conditions where their homing has been optimized by fucosylation. ..
- Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicityRobert Meller; Fiscal Year: 2012..It is our aim to investigate these mechanisms to help develop new therapeutics for stroke, or for circumstances where ischemia can be predicted, such as heart bypass surgery. ..
- Transcutaneous vagus nerve stimulation in cerebral ischemiaIlknur Ay; Fiscal Year: 2013..If successful, the findings of these exploratory studies will be used in near future translational studies designed to optimize tVNS treatment for acute ischemic stroke in humans. ..
- Development of Potent/Selective Lipoxygenase Therapeutics Against Stroke InjuryTheodore R Holman; Fiscal Year: 2013..Considering that our "validated hit" manifests a 30% reduction in infarct size, we are confident these studies will discover a 12/15- LOX inhibitor as an effective therapeutic against stroke damage. ..
- Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for StrokeIrina Y Sazonova; Fiscal Year: 2012..In this project we propose a novel thrombolytic agent and plan to determine its efficacy for the treatment in an experimental model of thromboembolic cerebral ischemia. ..
- Enhanced Risk Adjustment Using Laboratory Test and Pharmacy DataAmresh Hanchate; Fiscal Year: 2013..abstract_text> ..
- Ac-SDKP for Treatment of Acute StrokeZheng Gang Zhang; Fiscal Year: 2013..These studies could potentially provide a new therapy to minimize the adverse effect of tPA on ischemic neurovascular damage, leading to improved neurological outcomes after acute stroke. ..
- TWEAK-Induced Neuroinflammation and Cerebral EdemaMANUEL SALVADOR YEPES; Fiscal Year: 2013..Importantly, if our hypothesis is correct, our findings should indicate whether inhibition of TWEAK-Fn4 binding is a valid new target for the treatment of patients with acute ischemic stroke. ..
- Transcranial Sonothrombolysis with Diagnostic UltrasoundThilo Hoelscher; Fiscal Year: 2013..Noninvasive 'Image-Guided Sonothrombolysis'at the bedside or even in the ambulance vehicle would be a major achievement in stroke therapy. ..
- Role of Hyperglycemia in Intracerebral HemorrhageEdward P Feener; Fiscal Year: 2013..This grant will examine the hypothesis that the direct effects of plasma kallikrein on hemostasis and peri-hematomal edema contribute to the poor ICH outcomes in diabetes and hyperglycemia. ..
- Thrombin Mediated Cytotoxicity during Cerebral IschemiaPatrick D Lyden; Fiscal Year: 2013....
- Targeting the Pial Collateral Circulation for Mitigation of Cerebral IschemiaJames E Faber; Fiscal Year: 2013..Identifying this major allele that when polymorphic impairs collateral formation may also provide a genetic marker for use in these same patient groups. ..
- New York-Presbyterian NETT ConsortiumStephan A Mayer; Fiscal Year: 2011....
- Prostanoid signaling and inflammation in aging and Alzheimer's diseaseKatrin I Andreasson; Fiscal Year: 2013..Our findings will be relevant to the development of novel therapeutic strategies targeting pro- inflammatory pathways in AD. ..
- DEFINING THE ISCHEMIC PENUMBRA WITH MAGNETIC RESONANCE OXYGEN METABOLISMANDRIA LEE FORD; Fiscal Year: 2013..Additionally, we will examine variables that may modify these thresholds of injury, including time-to-imaging, tissue type (gray vs. white matter), and baseline clinical characteristics. ..
- A multiethnic comparative effectiveness study for diagnosis of cardiogenic strokeJeffrey R Gulcher; Fiscal Year: 2011..Improved detection of atrial fibrillation, especially in patients who have had a recent stroke may substantially decrease both the recurrent stroke rate and the cost of healthcare. ..
- Phase II Trial of Tiopronin in Aneurysmal Subarachnoid HemorrhageEDWARD SANDER CONNOLLY; Fiscal Year: 2011..This would spark further study that could further explore neuroprotective pre-treatment of cerebral ischemia, and thus help neutralize a major source of morbidity and mortality in this disease process. ..
- Racial & Ethnic Disparities in Incidence and Inpatient Outcomes of Acute StrokeAmresh D Hanchate; Fiscal Year: 2010..For effective targeting of interventions and public policy, our study aims to use evidence to identify and prioritize modifiable factors appropriate for each minority cohort. ..
- Insights on Selected Procoagulation Markers and Outcomes in Stroke Trial (I-SPOT)ANGARA KONETI RAO; Fiscal Year: 2013....
- Examining Vascular Regulation Following Acute StrokeSandra Billinger; Fiscal Year: 2013..However, before a clinical trial is undertaken, it is important and essential that one understands the role of pro-inflammatory markers and vascular function during stroke recovery. ..
- Mediators of Functional Hyperemia and Its Dysregulation in Post-Traumatic BrainMaiken Nedergaard; Fiscal Year: 2010....
- ARFI ultrasound for noninvasive, Diagnostic atherosclerosis imagingCaterina M Gallippi; Fiscal Year: 2013..Furthermore, their ability to predict plaque risk for causing cerebrovascular accident (CVA) has not been well established (Raggi et al 2005)...
- Diffuse Optics for Acute Stroke ManagementArjun G Yodh; Fiscal Year: 2012..abstract_text> ..
- The epidemiology of sleep apnea in a bi-ethnic stroke populationLynda D Lisabeth; Fiscal Year: 2013....
- UCLA SPOTRIAS CENTER APPLICATION RENEWAL-PROGRAM PROJECTJeffrey L Saver; Fiscal Year: 2012..A Career Development Program will train the next generation of translational scientists in neurovascular disease at the premedical, medical student, and fellowship level. ..
- Microglial Toll-like Receptor-4 and Ischemic PreconditioningJonathan R Weinstein; Fiscal Year: 2013..A major goal of this research project is to increase our mechanistic understanding of stroke pathophysiology. By doing so, we hope to identify novel cellular and molecular targets for therapeutic intervention in acute stroke. ..
- Metabolomic analysis of acute stress hyperglycemia in ischemic strokeWILLIAM TAYLOR KIMBERLY; Fiscal Year: 2013..Kimberly with the skills that are essential for him to develop an independent career in cerebrovascular research at the cutting edge of science. ..
- The New York City Collaborative Regional Coordinating Stroke CenterStanley Tuhrim; Fiscal Year: 2013..Three rehabilitation hospitals, including the preeminent Rusk Institute at NYU, Beth Abraham at Einstein and the Rehabilitation Center at ISMMS are also key network partners. ..
- Cyclooxygenase 2 and Ischemic Neuronal InjurySteven H Graham; Fiscal Year: 2012..The current project aims to identify a downstream mechanism by which COX2 activity injures neurons which could lead to new treatments for stroke and neurodegenerative diseases. ..
- Electrical stimulation of motor cortex: a candidate adjuvant to stroke therapy?JAMES WILLIAM STINEAR; Fiscal Year: 2010..The proposed research has the potential to develop a safe, low-cost, easily administered auxiliary treatment for walking retraining that could promote a major increase in walking ability and independence following stroke. ..
- Acute Stroke Program of Interventions: Racial &Ethnic Disparities(ASPIRE)CHELSEA M KIDWELL; Fiscal Year: 2011..abstract_text> ..
- Stroke Treatment by Chemically-Induced HypothermiaShan Ping Yu; Fiscal Year: 2012..Our ultimate goal is to advance the drug-induced hypothermia therapy to the clinic. ..
- Field Administration of Stroke Therapy-Magnesium Trial (FAST-MAG)Jeffrey L Saver; Fiscal Year: 2013....
- Establishment of fast pH MRI for imaging metabolic injury during acute strokePhillip Zhe Sun; Fiscal Year: 2013....
- Development and Validation of a VA Stroke Swallowing Screening ToolSTEPHANIE KAY DANIELS; Fiscal Year: 2013....
- New England Regional Coordinating Center for the NINDS Stroke Trials NetworkLee H Schwamm; Fiscal Year: 2013..Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1, 2 and 3 studies. ..
- Washington University SPOTRIAS CenterCOLIN PIETER DERDEYN; Fiscal Year: 2012..Finally, we will evaluate a novel MR sequence for the determination of cerebral oxygenation (Project 3). This has promise as a method to reliably identify injured tissue that will progress to infarction without therapy. ..
- Imaging Study of Combination Thrombolytic TherapyGEORGE JEROME SHAW; Fiscal Year: 2010..The results of this work could easily be taken from "bench to bedside" by virtue of the candidate's ongoing collaboration with Greater Cincinnati/Northern Kentucky stroke team. ..
- Mechanisms of Vascular Protection after Acute StrokeSusan C Fagan; Fiscal Year: 2013..This project will determine the mechanisms of vascular protection after stroke and develop a medication treatment likely to work in stroke patients. ..
- PHILA-NETT: Neurological Emergencies Treatment Trials (NETT) Network Clinical HubNina T Gentile; Fiscal Year: 2013....
- South Carolina Collaborative Alliance for Stroke Trials (SC-CoAST)Edward C Jauch; Fiscal Year: 2013....
- Specialized Programs of Translational Research in Acute Stroke at the PartnersSteven M Greenberg; Fiscal Year: 2013..If our study is successful, we can potentially expand use of lytics to a stroke patient population for whom little acute intervention is currently offered. ..
- Sleep apnea health disparities in Mexican American stroke patientsLynda D Lisabeth; Fiscal Year: 2013..It will also allow for the rigorous study of ethnic comparisons of sleep apnea after stroke in European Americans and Hispanics, the largest minority in the United States. ..
- A Novel Ultrasound Phased Array and Sonication Method for Stroke TreatmentsKullervo Hynynen; Fiscal Year: 2012..During this research we plan to develop such a system and perform all of the experiments needed prior to starting clinical trials. This research may have a major impact on patient care. ..
- Miami Regional Coordinating Center for NINDS Stroke Trials NetworkJose G Romano; Fiscal Year: 2013..Therefore, we have the depth and breadth of expertise and resources to successfully function as a RCC in the Stroke Trials Network. ..
- Protective mechanisms of ischemic postconditioningHeng Zhao; Fiscal Year: 2013..Specific Aim 3. To examine the protective effects of the Akt/PRAS40 pathway on the pro-inflammatory response of HMGB1 and Cox-2, and the galectin-9/Tim-3 inflammatory pathway. ..
- Donepezil to promote functional recovery post-strokeEllen M Whyte; Fiscal Year: 2013..This study holds promise to identify a pharmacologic intervention, which when combined with rehabilitation, would be a simple and widely generalizable strategy to promote post-stroke functional recovery. ..
- Stroke Imaging of Conscious RatsTimothy Q Duong; Fiscal Year: 2013..These findings have the potential to positively impact stroke research, including testing of novel therapeutic strategies, as well as enhance clinical decision making in the treatment of acute stroke. ..
- MMPs contribute to hyperthermia-enhanced vascular injuryChen Xu Wang; Fiscal Year: 2011..Therefore, the information obtained from the proposed studies should benefit the development of new therapeutic strategies and improve the clinical management of stroke patients. ..
- Therapeutic Window for Acute Stroke Therapy (P50)Brett C Meyer; Fiscal Year: 2012..abstract_text> ..
- An Observational Acute Stroke Model for Decision Support and Comparing OutcomesGary Duckwiler; Fiscal Year: 2013..The ultimate result of this effort will be a set of informatics-driven modeling tools and a database for acute stroke treatment. ..
- Impact of Regionalization of Care in Acute Stroke PatientsPrasanthi Govindarajan; Fiscal Year: 2013..By providing evidence for patient outcomes in a regionalized stroke system.our research will provide scientific knowledge to promote health policy changes of great public health importance at a national level. ..
- Center for Stroke Disaparities SolutionOlajide Williams; Fiscal Year: 2013....
- Who Benefits from tPA 3-6 hours after StrokeMaarten G Lansberg; Fiscal Year: 2010..They will provide guidance throughout the award period and facilitate his transition into a successful independent investigator. ..
- PRAISE: Preventing recurrence of all inner-city strokes through education;Carol R Horowitz; Fiscal Year: 2011..Finally, if the trial is successful, we will work to sustain the program locally, disseminate the results nationally, and use the lessons learned to inform health policy. ..
- Reducing Brain Injury After Focal Ischemia Using a Nitric Oxide-Neutral Oxygen CaSTEPHEN CARY; Fiscal Year: 2012..amp;'#(%)*+ ",-./01+%-23+4+5677+ #"(+$"8+&%9(8%:;(%"#+ ..
- Arterial Spin Labeled Perfusion MRI in Acute Ischemic StrokeDANNY JIONG JIONG WANG; Fiscal Year: 2013..It is a translational project with the goal to develop and validate an entirely noninvasive and quantitative MRI method for routine clinical evaluation of AIS as well as other cerebrovascular disorders. ..
- Ambient Particles and Ischemic and Hemorrhagic StrokeMurray A Mittleman; Fiscal Year: 2010..In this study, we will evaluate 16,000 patients with stroke to evaluate the effect of air pollution as a potential trigger of stroke onset. ..
- Thrombolysis and Acute Stroke Treatment (TAST) 2011: Forward to Acute Stroke TreGregory J del Zoppo; Fiscal Year: 2011..1 ..
- Translation of pH-weighted MRI to Image Human Acute StrokeALMA SORENSEN; Fiscal Year: 2009..We propose to translate and evaluate the recently developed pH weighted MRI as a new imaging marker for human ischemic tissue, which has potential to improve the diagnostic value of MRI and assist with image-guided stroke therapy. ..
- Novel Biomarkers for Stroke InjuryMONIKA OLI; Fiscal Year: 2005..In addition, both the SBDP150 and SBDP120 ELISA will be validated in CSF and serum in a rodent model of stroke injury (MCAO injury). (Months 4-6) ..
- SPATIALLY ORIENTED DATABASE FOR DIGITAL BRAIN IMAGESEdward H Herskovits; Fiscal Year: 2010..We expect that, as we implement more components of this software suite, neuroscientists will find it much easier to perform complex multivariate analyses of their data relating structure and function of the human brain. ..
- MR ASSESSMENT OF MAGNESIUM IN ACUTE STROKEChelsea Kidwell; Fiscal Year: 2003..abstract_text> ..
- Profiling Plasma Unbound Free Fatty Acids for Early Detection of StrokeALAN MARC KLEINFELD; Fiscal Year: 2010..The use of this test would potentially reduce neurological damage from ischemic stroke by reducing the time required to diagnose and treat stroke patients. ..
- TISSUE VIABILITY IN STROKE BY SODIUM MR IMAGINGKeith Thulborn; Fiscal Year: 2003..abstract_text> ..
- TISSUE VIABILITY IN STROKE BY SODIUM MR IMAGINGKeith Thulborn; Fiscal Year: 2002..abstract_text> ..
- rLOAD: Loading of Aspirin and Clopidogrel in Rabbit Model of Ischemic StrokeDawn Meyer; Fiscal Year: 2009..This animal model research will translate into the support of a new stroke therapy that will limit brain injury, extend healthy life, and reduce disability from ischemic stroke. ..
- Older Adults and Specialty Care Use in Managed CareMaureen Smith; Fiscal Year: 2002..The proposed research will provide valuable information to clinicians, policymakers and researchers interested in the effects of managed care and health care providers (i.e., hospitals) on acutely-ill older patients. ..
- CARDIAC AUTONOMIC CONSEQUENCES OF HEMISPHERE STROKEStephen Oppenheimer; Fiscal Year: 1999..Control groups for comparison will include TIA patients and age-matched normal individuals. Accomplishment of these aims should indicate prevention strategies for the most common cause of post-stroke death. ..