middle cerebral artery infarction

Summary

Summary: The formation of an area of coagulation necrosis in the vascular distribution of the middle cerebral artery secondary to ISCHEMIA. Clinical features include contralateral weakness and loss of sensation in the arm and face and a contralateral homonymous hemianopsia. Dominant hemisphere lesions may produce APHASIA, alexia, AGRAPHIA, acalculia, finger agnosia, and right-left confusion. Nondominant hemisphere lesions may produce unilateral neglect, dressing APRAXIA, anosognosia, and constructional apraxia. (From Adams et al., Principles of Neurology, 6th ed, p786)

Top Publications

  1. ncbi Timing of neurologic deterioration in massive middle cerebral artery infarction: a multicenter review
    Adnan I Qureshi
    Department of Neurosurgery, State University of New York at Buffalo, USA
    Crit Care Med 31:272-7. 2003
  2. ncbi Stroke-induced neurogenesis in aged brain
    Vladimer Darsalia
    Laboratory of Neural Stem Cell Biology, University Hospital, The Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden
    Stroke 36:1790-5. 2005
  3. ncbi A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke
    Kenneth Pollock
    ReNeuron Ltd, 10 Nugent Road, Surrey Research Park, Guildford, Surrey GU2 7AF, UK
    Exp Neurol 199:143-55. 2006
  4. ncbi Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke
    Javier R Caso
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense Madrid, 28040 Madrid, Spain
    Circulation 115:1599-608. 2007
  5. ncbi Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial
    Jeannette Hofmeijer
    Department of Neurology, Rijnstate Hospital, Wagnerlann 55, Arnhem, Netherlands
    Lancet Neurol 8:326-33. 2009
  6. ncbi Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats
    J Chen
    Henry Ford Health Sciences Center, Department of Neurology, Detroit, Michigan, USA
    Stroke 32:1005-11. 2001
  7. ncbi Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion
    Rong Zhang
    State Key Laboratory of Medical Neurobiology, Institute for Biomedical Sciences, Shanghai Medical College of Fudan University, 138, Yi Xue Yuan Road, Shanghai 200032, P R China
    Neurobiol Dis 24:345-56. 2006
  8. pmc Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke
    Wenlan Liu
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Neurochem 107:1196-205. 2008
  9. ncbi MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia
    Marie Henriksson
    Division of Experimental Vascular Research, Department of Clinical Sciences in Lund, BMC A13, Lund University, Lund, 221 84 Sweden
    Exp Brain Res 178:470-6. 2007
  10. ncbi Flow cytometric analysis of inflammatory cells in ischemic rat brain
    Marilena Campanella
    Schering Plough Research Institute, Milan, Italy
    Stroke 33:586-92. 2002

Detail Information

Publications318 found, 100 shown here

  1. ncbi Timing of neurologic deterioration in massive middle cerebral artery infarction: a multicenter review
    Adnan I Qureshi
    Department of Neurosurgery, State University of New York at Buffalo, USA
    Crit Care Med 31:272-7. 2003
    ..symptom onset and neurologic deterioration related to cerebral edema in patients with massive middle cerebral artery infarction. The time period between onset and neurologic deterioration represents the window for surgical ..
  2. ncbi Stroke-induced neurogenesis in aged brain
    Vladimer Darsalia
    Laboratory of Neural Stem Cell Biology, University Hospital, The Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden
    Stroke 36:1790-5. 2005
    ..We explored whether stroke influences neurogenesis similarly in the aged brain...
  3. ncbi A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke
    Kenneth Pollock
    ReNeuron Ltd, 10 Nugent Road, Surrey Research Park, Guildford, Surrey GU2 7AF, UK
    Exp Neurol 199:143-55. 2006
    ..These data indicate that CTX0E03 has the appropriate biological and manufacturing characteristics necessary for development as a therapeutic cell line...
  4. ncbi Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke
    Javier R Caso
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense Madrid, 28040 Madrid, Spain
    Circulation 115:1599-608. 2007
    ..We have therefore investigated whether cerebral ischemia and inflammation produced by permanent occlusion of the middle cerebral artery differ in mice that lack a functional TLR4 signaling pathway...
  5. ncbi Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial
    Jeannette Hofmeijer
    Department of Neurology, Rijnstate Hospital, Wagnerlann 55, Arnhem, Netherlands
    Lancet Neurol 8:326-33. 2009
    ..The aim of HAMLET was to assess the effect of decompressive surgery within 4 days of the onset of symptoms in patients with space-occupying hemispheric infarction...
  6. ncbi Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats
    J Chen
    Henry Ford Health Sciences Center, Department of Neurology, Detroit, Michigan, USA
    Stroke 32:1005-11. 2001
    ..CONCLUSIONS: MSCs delivered to ischemic brain tissue through an intravenous route provide therapeutic benefit after stroke. MSCs may provide a powerful autoplastic therapy for stroke...
  7. ncbi Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion
    Rong Zhang
    State Key Laboratory of Medical Neurobiology, Institute for Biomedical Sciences, Shanghai Medical College of Fudan University, 138, Yi Xue Yuan Road, Shanghai 200032, P R China
    Neurobiol Dis 24:345-56. 2006
    ..Increasing neurogenesis and preventing the death of newborn neuron may be a strategy to aid in the repair of adult brain after stroke...
  8. pmc Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke
    Wenlan Liu
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Neurochem 107:1196-205. 2008
    ....
  9. ncbi MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia
    Marie Henriksson
    Division of Experimental Vascular Research, Department of Clinical Sciences in Lund, BMC A13, Lund University, Lund, 221 84 Sweden
    Exp Brain Res 178:470-6. 2007
    ..The vascular effects of U0126 provide new perspective on possible mechanisms of actions of MAPK inhibition in cerebral ischaemia...
  10. ncbi Flow cytometric analysis of inflammatory cells in ischemic rat brain
    Marilena Campanella
    Schering Plough Research Institute, Milan, Italy
    Stroke 33:586-92. 2002
    ..However, this technique has not been applied to the study of cerebral ischemia inflammation. The aim of this study was to establish a flow cytometric method to measure inflammatory cells in ischemic brain...
  11. ncbi Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke
    Mushfiquddin Khan
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci Res 76:519-27. 2004
    ..These results indicate that in a rat model of experimental stroke, administration of NAC even after ischemia onset protected the brain from free radical injury, apoptosis, and inflammation, with a wide treatment window...
  12. ncbi Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke
    Aneesh B Singhal
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurology 58:945-52. 2002
    ..Hyperbaric oxygen therapy is considered an important stroke treatment strategy...
  13. ncbi Temporary middle cerebral artery occlusion in the rat: consistent protocol for a model of stroke and reperfusion
    B S Aspey
    Reta Lila Weston Institute of Neurological Studies, UCL Medical School, London, UK
    Neuropathol Appl Neurobiol 26:232-42. 2000
    ....
  14. ncbi Eubaric hyperoxemia and experimental cerebral infarction
    Erin P Flynn
    Department of Pathology and Laboratory Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Ann Neurol 52:566-72. 2002
    ..net effect of continuous (intraischemic plus postischemic) oxygen therapy toxic, or beneficial to middle cerebral artery infarction? (3) In view of free radical theories of reperfusion injury, does hyperoxia isolated to the ..
  15. ncbi Role of IL-1alpha and IL-1beta in ischemic brain damage
    H Boutin
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 21:5528-34. 2001
    ....
  16. ncbi Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    Shan Zhu
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 417:74-8. 2002
    ..Because of the safety record of minocycline, and its ability to penetrate the blood-brain barrier, this drug may be a novel therapy for ALS...
  17. ncbi Functional assessments in mice and rats after focal stroke
    A J Hunter
    Neurosciences Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, UK
    Neuropharmacology 39:806-16. 2000
    ..Further characterisation of these tasks will enhance their utility meaningful preclinical means of assessing functional recovery of the administration of potential neuroprotective and regenerative therapies...
  18. ncbi Selective neuronal vulnerability following mild focal brain ischemia in the mouse
    Juri Katchanov
    Klinik und Poliklinik fur Neurologie, Charite Campus Mitte, Humboldt Universitat zu Berlin, Germany
    Brain Pathol 13:452-64. 2003
    ..A low density of glutamate receptors, the ability to sequester calcium by calcium-binding proteins and other hitherto unidentified factors may explain this relative resistance of interneurons to acute ischemia...
  19. ncbi Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice
    Barry W McColl
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 28:9451-62. 2008
    ..These mechanisms may contribute to the poor clinical outcome in stroke patients presenting with antecedent infection...
  20. ncbi Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain
    Priyanka Rathore
    Division of Pharmacology, Central Drug Research Institute, P O Box No 173, Chattar Manzil Palace, Lucknow, UP, 226001, India
    Neurochem Res 33:1672-82. 2008
    ..C.oil appears to be a promising agent not only for the treatment of cerebral stroke, but also for the treatment of other disorders associated with oxidative stress...
  21. ncbi Utility of perfusion-weighted CT imaging in acute middle cerebral artery stroke treated with intra-arterial thrombolysis: prediction of final infarct volume and clinical outcome
    M H Lev
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Stroke 32:2021-8. 2001
    ..The goal of this study was to evaluate the utility of perfusion-weighted CT (PWCT) in predicting final infarct volume and clinical outcome in patients with acute middle cerebral artery (MCA) stroke...
  22. ncbi Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion
    Mami Ishikawa
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    J Cereb Blood Flow Metab 24:907-15. 2004
    ..These findings implicate a major role for both platelet-associated and endothelial cell-associated P-selectin, as well as neutrophils in the inflammatory and prothrombogenic responses in the microcirculation after focal cerebral I/R...
  23. ncbi Malignant middle cerebral artery infarction: clinical characteristics, treatment strategies, and future perspectives
    Hagen B Huttner
    Department of Neurology, University of Erlangen, Germany
    Lancet Neurol 8:949-58. 2009
    ....
  24. ncbi Monitoring intracranial pressure in patients with malignant middle cerebral artery infarction: is it useful?
    Maria Antonia Poca
    Department of Neurosurgery, Vall d Hebron University Hospital, Institut Recerca Vall d Hebron, Autonomous University of Barcelona, 08035 Barcelona, Spain
    J Neurosurg 112:648-57. 2010
    ..This study aimed to present the findings of continuous ICP monitoring in a cohort of patients with malignant MCA infarction and to correlate these findings with clinical and radiological features...
  25. ncbi Comparison of silicon-coated nylon suture to plain nylon suture in the rat middle cerebral artery occlusion model
    Norihito Shimamura
    Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    J Neurosci Methods 156:161-5. 2006
    ..We conclude that the commercially available silicone-coated occlusion suture provides better occlusion of the middle cerebral artery than the traditional uncoated nylon suture. Classification: Disease-related neuroscience (Section 6)...
  26. ncbi Ultra-early decompressive craniectomy for malignant middle cerebral artery infarction
    Der Yang Cho
    Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan, People s Republic of China
    Surg Neurol 60:227-32; discussion 232-3. 2003
    Early surgical decompressive craniectomy (less than 24 hours) for malignant middle cerebral artery infarction (MCA) provides life-saving benefits...
  27. ncbi Quality of life and neurobehavioral changes in survivors of malignant middle cerebral artery infarction
    Bessy Benejam
    Neurosurgery and Neurotraumatology Research Unit, Vall d Hebron University Hospital and Vall d Hebron Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neurol 256:1126-33. 2009
    ..The results show that younger patients had a significantly better outcome. QoL seems to be acceptable in both left- and right-sided infarctions, and retrospective agreement to hemicraniectomy is high in both patients and their relatives...
  28. ncbi Hemorrhagic transformation is related to the duration of occlusion and treatment with tissue plasminogen activator in a nonembolic stroke model
    Susan C Fagan
    Department of Neurology, Medical College of Georgia, Veteran s Affairs Medical Center, Augusta, GA, USA
    Neurol Res 25:377-82. 2003
    ..001) and without HT (p < 0.001), but only in animals with durations of occlusion of 2 h or more. Duration of occlusion is an important predictor of HT in transient MCAO in the rat and is closely associated with EBA expression...
  29. ncbi Hypoplasia or occlusion of the ipsilateral cranial venous drainage is associated with early fatal edema of middle cerebral artery infarction
    Wengui Yu
    Department of Neurological Surgery and Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8855, USA
    Stroke 40:3736-9. 2009
    ..The objective of this study was to examine the contribution of ipsilateral cranial venous abnormalities to the development of cerebral edema in middle cerebral artery infarction.
  30. ncbi Computed tomographic parameters predicting fatal outcome in large middle cerebral artery infarction
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Cerebrovasc Dis 16:230-5. 2003
    ..As yet there are few guidelines to aid the selection of patients for aggressive interventional therapies, such as decompression hemicraniectomy and/or hypothermia...
  31. ncbi Outcome and prognostic factors of decompressive hemicraniectomy in malignant middle cerebral artery infarction
    Chun Chung Chen
    Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan, ROC
    J Chin Med Assoc 70:56-60. 2007
    ..The aims of our study were to determine survival rate and functional out-come and to determine factors associated with survival rates and functional outcome in patients with malignant MCA infarction...
  32. ncbi Hemicraniectomy for middle cerebral artery infarction
    Hagen B Huttner
    Department of Neurology, University of Erlangen, Erlangen, Germany
    Curr Neurol Neurosci Rep 8:526-33. 2008
    The space-occupying so-called "malignant" middle cerebral artery infarction is-besides acute basilar artery occlusion-the most devastating form of ischemic stroke. Until recently, there was no proven treatment...
  33. ncbi Prediction of malignant middle cerebral artery infarction by magnetic resonance imaging within 6 hours of symptom onset: A prospective multicenter observational study
    Gotz Thomalla
    Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Ann Neurol 68:435-45. 2010
    ..We tested the hypothesis that acute stroke magnetic resonance imaging (MRI) predicts MMI within 6 hours of stroke onset...
  34. pmc Is decompressive craniectomy for malignant middle cerebral artery infarction of any worth?
    Xiao Feng Yang
    Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    J Zhejiang Univ Sci B 6:644-9. 2005
    ..The aim of this study was to determine the value of decompressive craniectomy in patients presenting malignant MCA infarction compared with those receiving medical treatment alone...
  35. ncbi Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum
    Toru Yamashita
    Bridgestone Laboratory of Developmental and Regenerative Neurobiology, Keio University School of Medicine, Shinanomachi, Tokyo 160 8582, Japan
    J Neurosci 26:6627-36. 2006
    ..These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders...
  36. ncbi Vasoconstrictive neurovascular coupling during focal ischemic depolarizations
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 26:1018-30. 2006
    ..Mitigating the vasoconstrictive neurovascular coupling during intense ischemic depolarizations may provide a novel hemodynamic mechanism of neuroprotection by inhibitors of CSD...
  37. ncbi Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-kappaB expression
    Ying Liu
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
    Brain Res 1268:174-80. 2009
    ..Whether this protective effect applies to ischemic injury in brain, we therefore investigate the potential neuroprotective role of oxymatrine and the underlying mechanisms...
  38. ncbi Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia
    Seija Lehnardt
    Center for Anatomy, Institute of Cell Biology and Neurobiology, Germany
    J Neuroimmunol 190:28-33. 2007
    ..In ischemic brains, TLR2 protein is expressed in lesion-associated microglia. Absence of TLR2 does not affect the recruitment of granulocytes to the infarct region. We conclude that TLR2 in microglia propagates stroke-induced CNS injury...
  39. ncbi Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Circulation 115:2323-30. 2007
    ..In the present study, we addressed the pathogenic role of GPIb, GPVI, and the aggregation receptor GPIIb/IIIa in experimental stroke in mice...
  40. ncbi Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production
    Kuo Tong Liou
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Brain Res 992:159-66. 2003
    ....
  41. ncbi Resolution of stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells
    T Veizovic
    ReNeuron Ltd, Department of Psychology, Institute of Psychiatry, King's College, London
    Stroke 32:1012-9. 2001
    ..CONCLUSIONS: MHP36 cells may improve functional outcome after MCAO by assisting spontaneous reorganization in both the damaged and intact hemispheres...
  42. ncbi Estrogen-induced recovery of autonomic function after middle cerebral artery occlusion in male rats
    T M Saleh
    Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada C1A 4P3
    Am J Physiol Regul Integr Comp Physiol 281:R1531-9. 2001
    ..These results suggest that both pre- or poststroke estrogen administration prevents or reverses acute stroke-induced autonomic dysfunction and that endogenous estrogen levels in males can contribute to this neuroprotection...
  43. ncbi Hematopoietic origin of microglial and perivascular cells in brain
    David C Hess
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Exp Neurol 186:134-44. 2004
    ....
  44. ncbi Neurological sequelae and long-term behavioural assessment of rats with transient middle cerebral artery occlusion
    M Modo
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
    J Neurosci Methods 104:99-109. 2000
    ....
  45. ncbi Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke
    Joan Montaner
    Neurovascular Research Laboratory, Stroke Unit, Vall d Hebron Hospital, Barcelona, Spain
    J Cereb Blood Flow Metab 23:1403-7. 2003
    ..50, 0.25-0.74; P < 0.001). Moreover, the extent of hypoperfused brain area (PWI) was associated with a proinflammatory cytokine release in the next hours (TNF-alpha and IL-6)...
  46. ncbi 17beta-Estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function
    Tracy D Farr
    7TMRI Facility and Wellcome Surgical Institute, Division of Clinical Neuroscience, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow, Scotland G61 1QH, UK
    Neurobiol Dis 23:552-62. 2006
    ..In conclusion, 17beta-estradiol treatment, delivered poststroke, did not influence recovery of function or synaptogenesis...
  47. ncbi Three-dimensional structure and survival of newly formed blood vessels after focal cerebral ischemia
    Jerzy Krupinski
    Department of Neurology, Hospital Universitario de Bellvitge, Barcelona, Spain
    Neuroreport 14:1171-6. 2003
    ..This normal growth pattern might be essential in future therapies involving induction of vascularization and neuroprotection to enhance long-term survival of the penumbra...
  48. ncbi Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue
    Ludy C Shih
    UCLA Stroke Center, UCLA Medical Center, Los Angeles, Calif, USA
    Stroke 34:1425-30. 2003
    ..Pretreatment perfusion MRI offers promise as a means to differentiate core from penumbral tissues...
  49. ncbi VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration
    Yaoming Wang
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci Res 85:740-7. 2007
    ....
  50. pmc Delayed minocycline but not delayed mild hypothermia protects against embolic stroke
    Chen Xu Wang
    Stroke Research Laboratory, Department of Medicine, University of Alberta, Canada
    BMC Neurol 2:2. 2002
    ..In the present study, effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia on focal embolic cerebral ischemia have been examined...
  51. ncbi Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats
    Shimin Liu
    College of Pharmacy and Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Cereb Blood Flow Metab 24:343-9. 2004
    ..The results support normobaric hyperoxia as a potential early intervention to save penumbral tissue in acute ischemic stroke...
  52. ncbi Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats
    Tibo Gerriets
    Department of Radiology Experimental Neurology Research Group Kerckhoff Klinik Bad Nauheim, Germany
    Brain Res Brain Res Protoc 12:137-43. 2004
    ..It does not permit reperfusion. This technique might provide information about the pathophysiological processes in the hyperacute phase of stroke...
  53. ncbi Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial)
    Katayoun Vahedi
    Service de Neurologie, Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Paris, France
    Stroke 38:2506-17. 2007
    ..There is no effective medical treatment of malignant middle cerebral artery (MCA) infarction. The purpose of this clinical trial was to assess the efficacy of early decompressive craniectomy in patients with malignant MCA infarction...
  54. ncbi Effects of minocycline alone and in combination with mild hypothermia in embolic stroke
    Chen Xu Wang
    Stroke Research Laboratory, 533 HMRC, University of Alberta, T6G 2S2, Edmonton, Canada
    Brain Res 963:327-9. 2003
    ..These results suggest that minocycline is beneficial in focal ischemic brain injury, and the lack of the enhanced neuroprotection may be due to the brief exposure to hypothermia...
  55. ncbi Cerebral ischemia upregulates vascular endothelin ET(B) receptors in rat
    Emelie Stenman
    Division of Experimental Vascular Research, Department of Internal Medicine, Lund University Hospital, Lund, Sweden
    Stroke 33:2311-6. 2002
    ..A role for ET may prove more important if the vascular receptors were changed. We addressed whether there is any change in ET receptor expression in cerebral ischemia...
  56. ncbi Neuroprotective efficacy of repinotan HCl, a 5-HT1A receptor agonist, in animal models of stroke and traumatic brain injury
    Frank Mauler
    Global Drug Safety, Bayer Health Care, PH R EU CNS, Wuppertal, Germany
    J Cereb Blood Flow Metab 25:451-9. 2005
    ..The favorable neuroprotective efficacy, broad dose-response curve, and prolonged therapeutic window observed in all models strongly suggest that repinotan is a promising candidate for treating acute ischemic stroke in humans...
  57. ncbi Fischer-344 rats are unsuitable for the MCAO filament model due to their cerebrovascular anatomy
    Michael S Dittmar
    Department of Anesthesiology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Neurosci Methods 156:50-4. 2006
    ..If the use of Fischer rats for studies on focal cerebral ischemia is indicated, other ischemia models than intraluminal suture occlusion should be chosen...
  58. ncbi The Neuroprotection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats
    Xiaohong Xu
    Department of Biomedical Engineering, Zhejiang University, Hangzhou, P R China
    Planta Med 71:585-91. 2005
    ..These results suggest that the neuroprotection of puerarin against cerebral ischemia is associated with anti-apoptosis...
  59. ncbi Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia
    Vemuganti L Raghavendra Rao
    Department of Neurological Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    J Neurochem 83:1072-86. 2002
    ..Antisense knockdown of ischemia-induced SOCS-3 protein expression exacerbated transient MCAO-induced infarct volume assigning a neuroprotective role to SOCS-3, a gene not heretofore implicated in ischemic neuronal damage...
  60. ncbi The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats
    Tibo Gerriets
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Neurosci Methods 122:201-11. 2003
    ..This technique causes hypothalamic injury resulting in hyperthermia, which can worsen outcome and obscure neuroprotective effects. Herein, we introduce a new MCAO model that avoids these disadvantages...
  61. pmc Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats
    Lin Xu
    Department of Neurology, Medical College of Georgia, Augusta GA, 30912, USA
    BMC Neurol 4:7. 2004
    ....
  62. ncbi Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke
    L D McCullough
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287-4961, USA
    Stroke 32:796-802. 2001
    ..This beneficial effect appears only during early reperfusion and likely complements other known mechanisms by which estrogen salvages brain from focal necrosis...
  63. ncbi Health status and life satisfaction after decompressive craniectomy for malignant middle cerebral artery infarction
    T S Skoglund
    Department of Neurosurgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Neurol Scand 117:305-10. 2008
    ..To study the long-term outcome in patients with malignant middle cerebral artery (MCA) infarction treated with decompressive craniectomy. The outcome is described in terms of survival, impairment, disabilities and life satisfaction...
  64. ncbi Neuroprotection by oxygen in acute transient focal cerebral ischemia is dose dependent and shows superiority of hyperbaric oxygenation
    C C Eschenfelder
    Department of Neurology, University Hospital Schleswig Holstein, Kiel, Germany
    Cerebrovasc Dis 25:193-201. 2008
    ..These data are important for the development of new acute stroke treatment studies in humans...
  65. ncbi Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat
    Preeti Dohare
    Division of Pharmacology, Central Drug Research Institute, Lucknow 226001, India
    Behav Brain Res 193:289-97. 2008
    ....
  66. ncbi Assessment of suitability of thrombolysis in middle cerebral artery infarction: a proof of concept study of a stereologically-based technique
    Thanh G Phan
    National Stroke Research Institute, Melbourne, Australia
    Cerebrovasc Dis 24:321-7. 2007
    ....
  67. ncbi Functional impairment, disability, and quality of life outcome after decompressive hemicraniectomy in malignant middle cerebral artery infarction
    Christian Foerch
    Department of Neurology and Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Neurosurg 101:248-54. 2004
    ..The authors sought to determine functional impairment, disability, and health-related quality of life (QOL) outcome in long-term survivors who had undergone this procedure, and tried to identify factors related to functional outcome...
  68. ncbi Middle cerebral artery occlusion in Macaca fascicularis: acute and chronic stroke evolution
    HELEN E D'ARCEUIL
    Neuroradiology Section, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    J Med Primatol 35:78-86. 2006
    ..This paper describes the care of animals undergoing this stroke procedure, the range of outcomes we experienced and the cause of mortality in this model...
  69. pmc Quality of life after decompressive craniectomy for malignant middle cerebral artery infarction
    K Vahedi
    J Neurol Neurosurg Psychiatry 76:1181-2. 2005
  70. ncbi Predictors of life-threatening brain edema in middle cerebral artery infarction
    Jeannette Hofmeijer
    Department of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 25:176-84. 2008
    We performed a systematic review to identify predictors of the development of life-threatening brain edema in patients with middle cerebral artery infarction.
  71. ncbi Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cereb Blood Flow Metab 27:1632-42. 2007
    ..Our data suggest that NBO may represent a promising strategy for acute stroke treatment...
  72. ncbi Assessment of outcome following decompressive craniectomy for malignant middle cerebral artery infarction in patients older than 60 years of age
    Ahmet Arac
    Department of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA
    Neurosurg Focus 26:E3. 2009
    ..The authors discuss their analysis, with specific reference to the limitations of the studies analyzed, the outcome measures used, and the special considerations required when discussing stroke recovery in the elderly...
  73. ncbi Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage
    X F Liu
    Stroke Lab, Alzheimer s Treatment and Research Center, Department of Neurology, Regions Hospital, 640 Jackson Street, Saint Paul, MN 55101 2595, USA
    J Neurol Sci 187:91-7. 2001
    ..Here, we demonstrate for the first time the therapeutic benefit of IN IGF-1 in rats following middle cerebral artery occlusion (MCAO)...
  74. pmc Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Brain 130:1631-42. 2007
    ..Our data show that normobaric hyperoxia increases tissue O2 delivery, and that novel mechanisms such as CBF augmentation, and suppression of PIDs may afford neuroprotection during hyperoxia...
  75. ncbi Hydroxyethylpuerarin attenuates focal cerebral ischemia-reperfusion injury in rats by decreasing TNF-alpha expression and NF-kappaB activity
    Hai Yan Lou
    Institute of Pharmacology, School of Medicine, Shandong University, Jinan 250012, China
    Yao Xue Xue Bao 42:710-5. 2007
    ..The protective effects of hydroxyethylpuerarin against ischemia-reperfusion injury may be mediated by decreasing the expression of TNF-alpha and the activity of NF-kappaB in rats...
  76. pmc Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein
    Xinhua Zhan
    Department of Neurology and M I N D Institute, University of California at Davis, Sacramento, CA 95817, USA
    Brain Res 1234:183-97. 2008
    ....
  77. ncbi Triphasic perfusion computed tomography in acute middle cerebral artery stroke: a correlation with angiographic findings
    K H Lee
    Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul, 135 710, Korea
    Arch Neurol 57:990-9. 2000
    ..To evaluate the usefulness of triphasic perfusion computed tomography (TPCT) in diagnosing middle cerebral artery (MCA) occlusion and in assessing the perfusion deficit and collateral circulation in patients with acute ischemic stroke...
  78. ncbi Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction
    Christian Dohmen
    Max Planck Institut für neurologische Forschung, Gleueler Strasse 50, D 50931 Köln, Germany
    Stroke 38:56-61. 2007
    ..autoregulation and its impact on clinical course in patients with impending malignant middle cerebral artery infarction, we used invasive multimodal neuromonitoring, including measurement of cerebral perfusion pressure, ..
  79. ncbi Modern anesthesia and peroperative monitoring methods reduce per- and postoperative mortality during transient occlusion of the middle cerebral artery in rats
    Annette Theodorsson
    Department of Biomedicine and Surgery, Division of Clinical Chemistry, University Hospital, SE 581 85 Linkoping, Sweden
    Brain Res Brain Res Protoc 14:181-90. 2005
    ..8%. A total number of 203 rats have been operated with this method in different studies where a focal reperfusion stroke model combined with extended periods of observations were the cornerstone...
  80. ncbi Protective mechanisms of inosine in platelet activation and cerebral ischemic damage
    George Hsiao
    Graduate Institute of Medical Sciences, Taipei Medical University, No 250, Wu Hsing Street, Taipei 110, Taiwan
    Arterioscler Thromb Vasc Biol 25:1998-2004. 2005
    ..In the present study, we further investigated the inhibitory effects of inosine on platelet activation in vitro and in vivo, as well as in attenuating middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats...
  81. ncbi Neuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance
    T Gerriets
    Department of Radiology, Experimental Neurology Research Group, Kerckhoff Klinik Bad, Nauheim, Germany
    Stroke 34:2234-9. 2003
    ..In the present study the neuroprotective effects of dizocilpine (MK-801) were compared in different permanent MCAO models with and without hypothalamic damage and hyperthermia...
  82. ncbi Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction
    SYLVAIN DORE
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Ann Neurol 54:155-62. 2003
    ....
  83. ncbi Neuroprotective effects of prostaglandin A(1) in rat models of permanent focal cerebral ischemia are associated with nuclear factor-kappaB inhibition and peroxisome proliferator-activated receptor-gamma up-regulation
    Hui Ling Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    J Neurosci Res 86:1132-41. 2008
    ..These findings suggest that PGA(1)-mediated neuroprotective effect against ischemia appears to be associated with blocking NF-kappaB activation and likely with up-regulating PPAR-gamma expression...
  84. ncbi Ischemic neuroprotection with selective kappa-opioid receptor agonist is gender specific
    Chih Hung Chen
    Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 36:1557-61. 2005
    ..We tested the hypothesis that BRL provides significant neuroprotection from transient focal ischemia in male but not in female rats...
  85. ncbi Effects of 17beta-oestradiol on cerebral ischaemic damage and lipid peroxidation
    Kirsty B Gordon
    Division of Clinical Neuroscience, Wellcome Surgical Institute, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow G61 1QH, UK
    Brain Res 1036:155-62. 2005
    ..Since oestrogen is an antioxidant, we tested the hypothesis that oestrogen reduces stroke-induced damage by reducing free radical damage, particularly lipid peroxidation...
  86. ncbi Prognosis of patients after hemicraniectomy in malignant middle cerebral artery infarction
    Birgit Walz
    Department of Neurology, Krankenhaus München Harlaching, Academic Teaching Hospital of the Ludwig Maximilians University München, Sanatoriumsplatz 2, 81545 München, Germany
    J Neurol 249:1183-90. 2002
    ..The aim of this study was to acquire follow-up data on quality of life and outcome in patients treated with hemicraniectomy after stroke...
  87. pmc Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway
    Aida Maddahi
    Division of Experimental Vascular Research, BMC A13, Lund University, 221 84 Lund, Sweden
    BMC Neurosci 9:85. 2008
    ..Here we explored the role of the MEK/ERK pathway in receptor expression following ischemic brain injury using the specific MEK1 inhibitor U0126...
  88. ncbi Delayed genomic responses to transient middle cerebral artery occlusion in the rat
    Jung Bin Kim
    Department of Anatomy, Inha University School of Medicine, 7 241 Shinheung dong, Jung Gu, Inchon 400 712, Korea
    J Neurochem 89:1271-82. 2004
    ..Together these results suggest that the pathophysiology of the postischemic brain proceeds by the transcriptional activation of genes related to the process of delayed neuronal damage and/or recovery and repair...
  89. ncbi Locomotion outcome in hemiplegic patients with middle cerebral artery infarction: the difference between right- and left-sided lesions
    Atsuko Goto
    Department of Neurology at Higashi Nagoya National Hospital, Nagoya, Japan
    J Stroke Cerebrovasc Dis 18:60-7. 2009
    ..This study was performed to analyze the locomotion outcome of hemiplegic patients with stroke and to explore the factors influencing it...
  90. ncbi In vivo imaging with cellular resolution of bone marrow cells transplanted into the ischemic brain of a mouse
    Alexy Tran-Dinh
    Cardiovascular Research Centre, INSERM U 689, Universite Paris 7, 10 Avenue de Verdun, 75010 Paris, France
    Neuroimage 31:958-67. 2006
    ..These results also provide the first in vivo findings on the fate of single BMCs transplanted into the ischemic brain of unirradiated mice...
  91. ncbi Differential effects of 17beta-estradiol upon stroke damage in stroke prone and normotensive rats
    Hilary V Carswell
    Wellcome Surgical Institute, Division of Clinical Neuroscience, University of Glasgow, Glasgow, Scotland, UK
    J Cereb Blood Flow Metab 24:298-304. 2004
    ..Despite being contrary to our hypothesis, our findings add substance to the recently reported negative effects of 17beta-estradiol in clinical studies...
  92. ncbi Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
    Eduardo Candelario-Jalil
    Department of Pharmacology, University of Havana CIEB IFAL, Apartado Postal 6079, Havana City 10600, Cuba
    Brain Res 1007:98-108. 2004
    ....
  93. ncbi Hemicraniectomy for malignant middle cerebral artery infarction
    Martin Kohrmann
    Department of Neurology, University of Erlangen, Erlangen, Germany
    Curr Opin Crit Care 15:125-30. 2009
    ..Several case series had suggested decompressive hemicraniectomy as a life-saving therapy, but, until recently, there was no proof for this procedure from randomized controlled trials...
  94. ncbi Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats
    Augusto Sola
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Res 57:481-7. 2005
    ..In conclusion, Epo given after FCI in neonatal rats provides significant neuroprotection, mediated possibly by activation of the Janus kinase-signal transducer and activator of transcription-Bcl-xL signaling pathways...
  95. ncbi Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
    Eduardo Candelario-Jalil
    Neurochemistry Research Group, Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 100:1108-20. 2007
    ....
  96. ncbi Matrix metalloproteinase expression after human cardioembolic stroke: temporal profile and relation to neurological impairment
    J Montaner
    Cerebrovascular Unit, Hemostasia Research Unit, Vall d Hebron Hospital, Barcelona, Spain
    Stroke 32:1759-66. 2001
    ..Therefore, we sought to determine the temporal profile of MMP expression in patients with acute ischemic stroke and to investigate its relationship to stroke severity, location of arterial occlusion, and total infarct volume...
  97. ncbi Multi-modal characterisation of the neocortical clip model of focal cerebral ischaemia by MRI, behaviour and immunohistochemistry
    Maria Ashioti
    Neuroimaging Research Group, Department of Neurology PO42, Institute of Psychiatry, Kings College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Brain Res 1145:177-89. 2007
    ..The correlation of MRI with two different behavioural measures and post-mortem histology strengthens the basis for MRI providing an in vivo surrogate marker for structural and behavioural deficits caused by a cortical stroke...
  98. ncbi Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats
    Dar Yu Yang
    Chang Bing Show Chwan Memorial Hospital, Changhua 542, Taiwan
    Neurotoxicology 28:1220-9. 2007
    ....
  99. ncbi Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis
    Xinkang Wang
    Department of Cardiovascular Sciences, Bristol Myers Squibb Company, Wilmington, Delaware 19880 0400, USA
    J Pharmacol Exp Ther 304:172-8. 2003
    ..Our data suggest that the inhibition of MEK1/2 results in neuroprotection from reperfusion injury and that this protection may be associated with the reduction in apoptosis...
  100. ncbi Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat
    Emelie Stenman
    Institution of Clinical Sciences Lund, Department of Experimental Vascular Research, Lund University, BMC A13, 22184 Lund, Sweden
    Eur J Pharmacol 570:142-8. 2007
    ..In conclusion, the present study shows that combined inhibition of angiotensin AT(1) and endothelin ET(A) receptors reduces the brain damage and improves the neurological outcome after ischemic stroke in rat...
  101. ncbi Acute administration of Ginkgo biloba extract (EGb 761) affords neuroprotection against permanent and transient focal cerebral ischemia in Sprague-Dawley rats
    E Jian Lee
    Neurophysiology Laboratory, Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center and Medical School, Tainan, Taiwan
    J Neurosci Res 68:636-45. 2002
    ..This neuroprotection may be at least partially attributed to the beneficial effects of selectively improved LCBF in the area at risk of infarction...

Research Grants73

  1. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..This proposal explores the therapeutic potential of D609 and how it affects lipid second messenger ceramide that regulates the cell cycle both in vitro and in vivo stroke models. ..
  2. White Matter Protection in Cerebral Ischemia
    Guodong Cao; Fiscal Year: 2013
    ..The effect of NAMPT on microglial myelin phagocytosis, oligodendrogenesis, WMI, and functional outcomes after ischemia will be evaluated. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
  3. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..We will then examine whether this effect is important in reducing the amount of tissue damage and neurologic impairment caused by the stroke. ..
  4. Homing of Stem Cells in Stroke Therapeutics
    EVAN YALE contact SNYDER; Fiscal Year: 2010
    ..hNSCs following peripheral administration 24 hrs post-stroke, particularly under conditions where their homing has been optimized by fucosylation. ..
  5. Endothelial Aromatase in Sex-Specific Cerebrovascular Dysfunction After Ischemia
    KRISTEN LEANNE ZULOAGA; Fiscal Year: 2012
    ....
  6. CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKE
    Costantino Iadecola; Fiscal Year: 2013
    ..Ultimately, the results of the proposed studies may suggest novel mechanism-based approaches to prevent or treat the deleterious effects of this highly prevalent condition. ..
  7. Development of Potent/Selective Lipoxygenase Therapeutics Against Stroke Injury
    Theodore R Holman; Fiscal Year: 2013
    ..Considering that our "validated hit" manifests a 30% reduction in infarct size, we are confident these studies will discover a 12/15- LOX inhibitor as an effective therapeutic against stroke damage. ..
  8. Dietary targeting of dihydrolipoamide dehydrogenase for stroke tolerance
    Liang Jun Yan; Fiscal Year: 2013
    ..It is expected that the successfully completed study will provide novel strategies using DLDH as a target for stroke therapeutics. ..
  9. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2013
    ..The hypothesis to be tested is that GPR30 agonist G1, like E2, alters Treg induction, mitigating immunosuppression while concurrently protecting the recovering brain. ..
  10. Neuron-Dervied S1P and Endothelial Function in Stroke
    Christian Waeber; Fiscal Year: 2010
    ..This project will study a novel system that can provide long-lasting improvement in EC function following stroke and serve as a target for stroke therapy. ..
  11. siRNA Therapy and Imaging Assessment in Ischemic Stroke
    Marytheresa Ifediba; Fiscal Year: 2012
    ....
  12. Intranasal deferoxamine to treat stroke in young and older, male and female rats
    SAMUEL SCOTT PANTER; Fiscal Year: 2013
    ..In phase 2, older male and female rats will be dosed utilizing the same regimens as phase 1. ..
  13. Ac-SDKP for Treatment of Acute Stroke
    Zheng Gang Zhang; Fiscal Year: 2013
    ..These studies could potentially provide a new therapy to minimize the adverse effect of tPA on ischemic neurovascular damage, leading to improved neurological outcomes after acute stroke. ..
  14. Perioperative Stroke and Cerebral Conditioning in the Female
    Stephanie J Murphy; Fiscal Year: 2010
    ..Our findings will elucidate the mechanisms by which female stroke outcomes are worsened by preischemic isoflurane exposure. ..
  15. TWEAK-Induced Neuroinflammation and Cerebral Edema
    MANUEL SALVADOR YEPES; Fiscal Year: 2013
    ..Importantly, if our hypothesis is correct, our findings should indicate whether inhibition of TWEAK-Fn4 binding is a valid new target for the treatment of patients with acute ischemic stroke. ..
  16. Histone deacetylases - therapeutic targets for functional restoration after strok
    SEAN PADRAIG MURPHY; Fiscal Year: 2013
    ..Selected drugs will be tested to reveal what functional benefits they confer on the recovery of mice from stroke injury. ..
  17. The role of ROCKs in stroke recovery
    Qing Mei Wang; Fiscal Year: 2013
    ..She has assembled a strong multidisciplinary mentoring team and the research will be conducted at the Brigham and Women's Hospital, which provides an excellent research environment and resources. ..
  18. Weibel-Palade Bodies: roles in thrombosis, inflammation and stroke
    Denisa D Wagner; Fiscal Year: 2013
    ..We will investigate how inhibition of a particular component of these vesicles could improve outcome in these major diseases. ..
  19. Fe porphyrin-based Redox Modulator in Experimental Stroke Outcome
    Ines Batinic-Haberle; Fiscal Year: 2013
    ..We propose to define efficacy of Fe analog in a mouse stroke model, which will open access to a whole new class of drugs with higher potency and safety, not only for stroke but potentially other CNS disorders including CNS malignancies. ..
  20. Acute Collateral Enhancement in Focal Stroke
    Al C Ngai; Fiscal Year: 2010
    ..The data collected may help pave the way for future studies on acute collateral pharmacotherapy in ischemic stroke. ..
  21. Mechanisms of Hyperbaric Oxygen Induced Brain Protection
    John H Zhang; Fiscal Year: 2013
    ..The clinical implication of HBO-PC, as an effective, easy to use, and safe modality, could be expanded to multiple brain injuries complicating major surgical procedures. ..
  22. US-China Collaborative Research on Stroke Imaging
    Jinyuan Zhou; Fiscal Year: 2013
    ..If the hypotheses are proven correct, we expect to have an additional marker that can be used for diagnosis and prognosis of stroke patients in the clinic. ..
  23. Mechanism of Vascular Dysfunction after Stroke in Postmenopausal Female
    Nabil J Alkayed; Fiscal Year: 2013
    ..We have identified a mechanism of injury specifically induced in female brain vessels after menopause, which may serve as a target for stroke therapy particularly effective in post-menopausal females. ..
  24. Chromosomal and Hormonal Contributions to Sex Differences in Ischemic Stroke.
    LOUISE DEBORAH MCCULLOUGH; Fiscal Year: 2013
    ..As recent clinical trials have shown variable efficacy of drugs in male and female patients, developing "sex- specific" therapeutic targets may improve our ability to treat stroke patients of both sexes. ..
  25. MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIA
    Gregory J del Zoppo; Fiscal Year: 2010
    ..These studies are likely to lead to new testable therapeutic approaches to preserve mlcrovascular and neuron function which will have relevance to other vascular neuron degenerative disorders. ..
  26. Mechanism of Hypoxia Inducible Factor 1 in Cerebral Ischemia
    Honglian Shi; Fiscal Year: 2012
    ..This research is expected to assist in developing effective therapies to ameliorate the cellular injuries in stroke patient through the identification of conditions that are optimal for HIF-1 mediated cell survival. ..
  27. Cytosolic Phospholipase A2 Alpha in Stroke Injury
    Adam Sapirstein; Fiscal Year: 2010
    ..The results of these studies will show if drugs aimed against the enzyme cPLA2a can be used to decrease injury following stroke and if the new protein, KIDS- cPLA2a has potential as a new brain-specific therapy for stroke. ..
  28. Microglial Toll-like Receptor-4 and Ischemic Preconditioning
    Jonathan R Weinstein; Fiscal Year: 2013
    ..A major goal of this research project is to increase our mechanistic understanding of stroke pathophysiology. By doing so, we hope to identify novel cellular and molecular targets for therapeutic intervention in acute stroke. ..
  29. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O'DONNELL; Fiscal Year: 2013
    ..We will also assess the efficacy of NKCC, NHE and NBC inhibitors for reduction of edema when administered after the onset of ischemia. ..
  30. Regulation of Stromal Derived Factor-1 Mediated Angiogenesis in Ischemic Brain
    Umadevi V Wesley; Fiscal Year: 2013
    ..Results from these studies may provide strong foundation for better understanding of novel targets and mechanisms of brain injury repair and may also open up a new direction for stroke therapy. ..
  31. Cord Blood is Neuroprotective in a Rat Model of Stroke
    Alison E Willing; Fiscal Year: 2010
    ..The ultimate goal of this research program is to develop an innovative HUCB cell based therapy into a viable clinical option for transplantation in neurodegenerative disease and brain injury. ..
  32. Neuronal Regeneration of Stroked Brain with Perlecan Domain V
    GREGORY JAYE BIX; Fiscal Year: 2013
    ....
  33. Neurorestorative therapy of stroke with HUCBC in T2DM rats
    Jieli Chen; Fiscal Year: 2013
    ..This proposal is highly clinically relevant and if successful, will significantly impact the treatment of diabetic and possibly all stroke patients. ..
  34. Neonatal Brain Ischemia: Neuroimaging as a Basis For Rational Stem Cell Therapy
    Stephen Ashwal; Fiscal Year: 2012
    ....
  35. Neurorestorative therapy of stroke with agents that increase HDL
    Jieli Chen; Fiscal Year: 2013
    ..This study provides a new and highly effective way to treat stroke and may permit translation of our findings to the patient. ..
  36. Role of Prokineticin 2 in Cerebral Ischemia
    Michelle Y Cheng; Fiscal Year: 2010
    ..We believe that PK2 may be an important modulator of ischemic injury, and thus a potential novel target for the treatment of stroke. ..
  37. TWEAK-Induced Ischemic Neuronal Death
    MANUEL SALVADOR YEPES; Fiscal Year: 2013
    ..This application focuses on the study of the mechanism whereby TWEAK induces cell death and the use of inhibitors of TWEAK activity as a potential therapeutic strategy to prevent neuronal death during acute ischemic stroke. ..
  38. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O'DONNELL; Fiscal Year: 2012
    ..We will use Western blot and immunoEM to evaluate BBB NBC protein in CMEC and in BBB in situ, and microspectrofluorometry to assess ischemic factor and hyperglycemia effects on CMEC NBC activity. ..
  39. Effects of Semaphorin 3A on Stroke Recovery
    Klaus van Leyen; Fiscal Year: 2013
    ..Can manipulating the semaphorin pathway lead to more efficient integration of neurons and an improved revascularization? This application is relevant to PA-08-099 "Mechanisms of functional recovery after stroke". ..
  40. A Novel Intervention Strategy for Stroke with RTL Therapy
    Halina Offner; Fiscal Year: 2013
    ..Upon completion of this Phase II STTR proposal, in partnership with Virogenomics, we will proceed to a Phase I safety trial in Stroke patients. ..
  41. Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapy
    Shaohua Yang; Fiscal Year: 2012
    ..The studies proposed will provide new insight on the mechanism of vascular dementia and identify potential therapeutic target for the prevention of cognitive decline following cerebral ischemia. ..
  42. Middle cerebral artery stroke: Non-contrast MR screening of high-risk plaque
    Chun Yuan; Fiscal Year: 2013
    ..Clinical use of high-risk plaque imaging may improve treatment options for stroke patients with large-artery atherosclerosis. ..
  43. The Capacity to Synthesize NPD1 is Reduced in Aged Brains
    TIFFANY NIEMOLLER EADY; Fiscal Year: 2012
    ....
  44. MECHANISMS OF MOTOR RECOVERY AFTER SUBTOTAL BRAIN INJURY
    Robert J Morecraft; Fiscal Year: 2013
    ..part of the motor cortex that is typically involved in the most common form of human stroke, namely middle cerebral artery infarction. Hand recovery will be tracked by analyzing 3-D hand and digit motion during reaching and grasping, ..
  45. MECHANISMS OF MOTOR RECOVERY AFTER SUBTOTAL BRAIN INJURY
    ROBERT MORECRAFT; Fiscal Year: 2009
    ..part of the motor cortex that is typically involved in the most common form of human stroke, namely middle cerebral artery infarction. Hand recovery will be tracked by analyzing 3-D hand and digit motion during reaching and grasping, ..
  46. Stroke Imaging of Conscious Rats
    Timothy Q Duong; Fiscal Year: 2013
    ..These findings have the potential to positively impact stroke research, including testing of novel therapeutic strategies, as well as enhance clinical decision making in the treatment of acute stroke. ..
  47. Hiltonol provides potent neuroprotection from ischemic brain injury in stroke.
    Mary P Stenzel-Poore; Fiscal Year: 2013
    ..Aim 2. Evaluate the duration of protection with Hiltonol. Aim 3. Validate translational biomarkers in mice. ..
  48. The Role of Stanniocalcin 2 in Calcium Homeostasis and Neuronal Pathology
    WILLIAM ABEL ZEIGER; Fiscal Year: 2012
    ..I will also use inhibitors of store-operated calcium entry to determine the importance of this pathway in STC2 mediated effects on glutamate-induced neuronal injury. ..
  49. A Novel Adjunct to Physical Training to Improve Motor Recovery Following Stroke
    Michael P Kilgard; Fiscal Year: 2013
    ..Further, recovery of function in animals that received VNS paired with training must maintain at least 90% of those gains for at least five weeks in the absence of subsequent training. ..
  50. Neonatal Stroke: the Role of Microglia
    Zinaida Vexler; Fiscal Year: 2013
    ..Finally, we will determine the effects of a lack/inhibition of CD36 on Lyn-mediated intracellular signaling in cultured microglia and the effects of altered CD36/Lyn signaling on injured cultured neurons (Aim 3). ..
  51. MECHANISMS OF ISCHEMIC NEONATAL BRAIN INJURY
    Donna M Ferriero; Fiscal Year: 2012
    ..RELEVANCE TO PUBLIC HEALTH: Achieving these goals will ultimately result in improved care and outcome in encephalopathic neonates, and potential therapies aimed at the repair process after neonatal ischemic events. ..
  52. Excitotoxicity and Inflammation
    Sandra J Hewett; Fiscal Year: 2013
    ..Results from this study will elucidate the contribution of L-12/15 LO to cerebral ischemic damage and could aid in the development of a novel stroke therapeutic. ..
  53. Delayed cognitive impairment after stroke
    Marion S Buckwalter; Fiscal Year: 2013
    ..This information will allow us to pursue critical future studies on the mechanisms that underlie post-stroke dementia, and in addition will provide a way to test potential therapies. ..
  54. M-Type K+ Channels: In Vivo Neuroprotective Role during Cerebrovascular Stro
    SONYA MARIE BIERBOWER; Fiscal Year: 2013
    ....
  55. Targeting CaM Kinase II for Neuroprotection in Ischemic Stroke
    Howard Schulman; Fiscal Year: 2012
    ..We aim to increase the brain penetration of our potent CaMKII inhibitors and test the optimized lead compound for efficacy in an animal model of human ischemic stroke.ischemic stroke. ..
  56. Macrophages as modulators of repair after neonatal stroke
    Zinaida Vexler; Fiscal Year: 2013
    ..Understanding the mechanisms regulating repair is an important first step on the way to successful bench-to-bed translation to enhance repair in injured newborn brains. ..
  57. The Role of Cdk5 in Stroke
    James A Bibb; Fiscal Year: 2013
    ....
  58. Control of Arm Posture and Movement Followoing Stroke
    Robert A Scheidt; Fiscal Year: 2012
    ..We anticipate that improvement in arm function will be promoted by applying robotic and biofeedback methods first to train coactivation, posture and movement control separately, then in combination. ..
  59. Treatment of stroke using a novel PDZ binding peptidomimetic drug.
    Angela L Slitt; Fiscal Year: 2011
    ..This will result in a drastically changed public health climate, resulting in less disability and longer, more productive life spans amongst the victims of stroke. ..
  60. Neuroprotective therapy of stroke with HUCNC and simvastatin
    Jieli Chen; Fiscal Year: 2010
    ..A clinically relevant embolic middle cerebral artery occlusion (MCAo) rat model will be used in this study, which will provide new and important data regarding novel therapeutic targets for stroke recovery. ..
  61. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2013
    ..These findings have the potential to open a new translational avenue for clinical therapies of cerebrovascular diseases. ..
  62. Mechanisms of structural neuronal plasticity and functional remapping after strok
    Carlos Portera-Cailliau; Fiscal Year: 2013
    ....
  63. Hypothermia in Acute Stroke with Thrombolysis Imaging Evaluation of Revasculariza
    DAVID SIGMUND LIEBESKIND; Fiscal Year: 2013
    ....
  64. APOLIPOPROTEIN E AND THE ISCHEMIC BRAIN
    David Warner; Fiscal Year: 2001
    ..We believe that this information would be of substantial value in defining both the relevance of Apo E mechanisms to ischemic outcome and provide a basis for therapeutic approaches to the treatment of stroke. ..
  65. Balanced, polyvalent antiglutamatergic action as a novel approach to efficacious
    Anatoly Martynyuk; Fiscal Year: 2009
    ....
  66. CEREBRAL ISCHEMIA--MINIMIZING DAMAGE DURING ANESTHESIA
    David Warner; Fiscal Year: 1992
    ..The proposed studies will contribute to our understanding of these problems...
  67. Nitric Oxide--Neurotoxic Mechanisms of MPTP
    Allen Mandir; Fiscal Year: 2002
    ..In this study we demonstrate that NMDA excitotoxicity is dramatically reduced in PARP-1 knockout mice whereas PARP-1 knockout mice are sensitive to AMPA excitotoxicity. ..
  68. Radical Scavengers for Brain Ischemia Reperfusion injury
    Howard Elford; Fiscal Year: 2003
    ..These data will provide important information regarding the efficacy of these compounds as therapeutic drugs to prevent or ameliorate brain ischemia reperfusion injury. ..
  69. IONIC BASIS OF ISCHEMIC CEREBRAL EDEMA
    Wise Young; Fiscal Year: 1992
    ..These studies will clarify ionic mechanisms in edema, relate tissue ionic shifts to tissue damage, and establish rational bases for treating ionic edema in stroke...
  70. CENTER FOR CNS INJURY STUDIES
    Mitchell Chesler; Fiscal Year: 2000
    ..Water movements will be investigated in slices from aged animals. The role of the Na:HCO3 cotransport will be assessed. Light scattering and Na-K changes will be compared with wet-dry weight and tracer measurements. ..
  71. NEUROTROPHIN ROLE IN OXIDATIVE HOMEOSTASIS AFTER STROKE
    JOSE PEREZ POLO; Fiscal Year: 1999
    ..These studies will provide insights into the mechanism of stroke pathophysiology and suggest new therapeutic approaches. ..
  72. A Novel Neuroprotective Approach for Ischemia
    Zhi Gang Jiang; Fiscal Year: 2007
    ..At the end of the phase II period, we expect to submit an IND application to the FDA to use PAN-811 for the treatment of transient ischemic stroke and initiate phase Ib clinical trials. [unreadable] [unreadable]..
  73. Soy phytoestrogen neuroprotection in cerebral ischemia
    DEREK SCHREIHOFER; Fiscal Year: 2007
    ..This proposal seeks to provide critical new information about the ability of phytoestrogens to protect the brain from focal cerebral ischemia. ..