carotid artery diseases

Summary

Summary: Diseases of the common, internal, and external carotid arteries. ATHEROSCLEROSIS and trauma are relatively frequent causes of carotid artery pathology.

Top Publications

  1. pmc The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study
    Hiroyuki Ito
    Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan
    Cardiovasc Diabetol 9:18. 2010
  2. ncbi Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis
    Matthias W Lorenz
    Johann Wolfgang Goethe University, Department for Neurology, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Circulation 115:459-67. 2007
  3. ncbi Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006
    P J Touboul
    Cerebrovasc Dis 23:75-80. 2007
  4. ncbi Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease
    Giovanni Targher
    Division of Internal Medicine and Diabetes Unit, Ospedale Sacro Cuore Don Calabria, Via Sempreboni 5, 37024 Negrar Vr, Italy
    Diabetes Care 29:1325-30. 2006
  5. ncbi Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS)
    Matthias W Lorenz
    Department of Neurology, Johann Wofgang Goethe University, Frankfurt am Main, Germany
    Stroke 37:87-92. 2006
  6. ncbi Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis
    Carlos Gonzalez-Juanatey
    Division of Cardiology, Hospital Xeral Calde, Lugo, Spain
    Semin Arthritis Rheum 38:366-71. 2009
  7. ncbi Association between arterial stiffness and atherosclerosis: the Rotterdam Study
    N M van Popele
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam (Netherlands
    Stroke 32:454-60. 2001
  8. ncbi Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, 46 rue Henri Huchard, 75018 Paris, France
    Stroke 35:2902-9. 2004
  9. ncbi Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging
    Jian Ming Cai
    Department of Radiology, University of Washington, Seattle, Wash 98195 7115, USA
    Circulation 106:1368-73. 2002
  10. pmc Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)
    Moise Desvarieux
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn, USA
    Circulation 111:576-82. 2005

Detail Information

Publications283 found, 100 shown here

  1. pmc The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study
    Hiroyuki Ito
    Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan
    Cardiovasc Diabetol 9:18. 2010
    ....
  2. ncbi Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis
    Matthias W Lorenz
    Johann Wolfgang Goethe University, Department for Neurology, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Circulation 115:459-67. 2007
    ..Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of data to examine this association...
  3. ncbi Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006
    P J Touboul
    Cerebrovasc Dis 23:75-80. 2007
    ..This will help to improve the power of randomized clinical trials incorporating IMT measurements and to facilitate the merging of large databases for meta-analyses...
  4. ncbi Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease
    Giovanni Targher
    Division of Internal Medicine and Diabetes Unit, Ospedale Sacro Cuore Don Calabria, Via Sempreboni 5, 37024 Negrar Vr, Italy
    Diabetes Care 29:1325-30. 2006
    ....
  5. ncbi Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS)
    Matthias W Lorenz
    Department of Neurology, Johann Wofgang Goethe University, Frankfurt am Main, Germany
    Stroke 37:87-92. 2006
    ..Carotid intima-media thickness (IMT) is an independent predictor of vascular events in age groups >45 years. However, there is little information about the predictive value of IMT in younger individuals...
  6. ncbi Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis
    Carlos Gonzalez-Juanatey
    Division of Cardiology, Hospital Xeral Calde, Lugo, Spain
    Semin Arthritis Rheum 38:366-71. 2009
    ..To establish whether carotid intima-media wall thickness (IMT) may be a good predictor for the development of cardiovascular (CV) events in patients with rheumatoid arthritis (RA)...
  7. ncbi Association between arterial stiffness and atherosclerosis: the Rotterdam Study
    N M van Popele
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam (Netherlands
    Stroke 32:454-60. 2001
    ..CONCLUSIONS: This population-based study shows that arterial stiffness is strongly associated with atherosclerosis at various sites in the vascular tree...
  8. ncbi Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University Paris VII, 46 rue Henri Huchard, 75018 Paris, France
    Stroke 35:2902-9. 2004
    ..Statin trials have now included >90,000 patients. We have determined the effect of statins and LDL-C reduction on stroke prevention...
  9. ncbi Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging
    Jian Ming Cai
    Department of Radiology, University of Washington, Seattle, Wash 98195 7115, USA
    Circulation 106:1368-73. 2002
    ..The purpose of this study was to determine whether in vivo high-resolution multicontrast MRI could accurately classify human carotid atherosclerotic plaque according to the American Heart Association classification...
  10. pmc Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)
    Moise Desvarieux
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn, USA
    Circulation 111:576-82. 2005
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and subclinical atherosclerosis...
  11. pmc Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes
    Hye Jin Yoo
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
    Cardiovasc Diabetol 10:103. 2011
    ..Omentin-1 is a recently discovered novel adipokine, so data about the relationship of this adipokine to vascular health in type 2 diabetes is limited...
  12. ncbi In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques
    C Yuan
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Circulation 104:2051-6. 2001
    ..The purpose of this study was to evaluate differential contrast-weighted images, specifically a multispectral MR technique, to improve the accuracy of identifying the lipid-rich necrotic core and acute intraplaque hemorrhage in vivo...
  13. ncbi Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study
    S Kiechl
    Departments of Neurology, University Clinic Innsbruck, Innsbruck, Austria
    Circulation 103:1064-70. 2001
    ..CONCLUSIONS: The present study provides solid evidence for a role of common chronic infections in human atherogenesis. Induction of systemic inflammation and autoimmunity may be potential pathophysiological links...
  14. pmc Segment-specific associations of carotid intima-media thickness with cardiovascular risk factors: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Joseph F Polak
    Department of Radiology, 299, Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA
    Stroke 41:9-15. 2010
    ....
  15. ncbi Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case-control study
    Angel Brea
    Lipid Clinic, Internal Medicine Service, Hospital San Millán San Pedro, Logrono, Spain
    Arterioscler Thromb Vasc Biol 25:1045-50. 2005
    ..Nonalcoholic fatty liver disease (NAFLD) frequently coexists with obesity, diabetes, and dyslipidemia. We examined whether NAFLD was associated with atherosclerosis, as measured by ultrasound in the carotid arteries...
  16. ncbi Fatty liver index, gamma-glutamyltransferase, and early carotid plaques
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hepatology 55:1406-15. 2012
    ..g., body mass index, waist circumference, plasma triglycerides, and GGT), the independent determinants of plaque presence were age (P < 0.001), GGT (P = 0.001), and current smoking (P < 0.05)...
  17. ncbi Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 Survey
    Teemu Koivistoinen
    Department of Clinical Physiology, University of Tampere and Tampere University Hospital, FI 33521, Tampere, Finland
    Atherosclerosis 220:387-93. 2012
    ....
  18. ncbi High-grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis
    Miguel A Gonzalez-Gay
    Divisions of Rheumatology and Cardiology, Hospital Xeral Calde, Lugo, Spain
    J Rheumatol 32:1219-23. 2005
    ..We examined the relationship between carotid IMT to C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which are the most commonly assessed markers of inflammatory response in patients with RA...
  19. ncbi Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 25:1038-44. 2005
    ....
  20. ncbi Dietary intervention to reverse carotid atherosclerosis
    Iris Shai
    Department of Epidemiology and Health Systems Evaluation, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Circulation 121:1200-8. 2010
    ..It is currently unknown whether dietary weight loss interventions can induce regression of carotid atherosclerosis...
  21. ncbi Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherosclerosis
    INMACULADA DEL RINCON
    University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Arthritis Rheum 52:3413-23. 2005
    ..To estimate the contribution of cardiovascular (CV) risk factors and rheumatoid arthritis (RA) disease manifestations to atherosclerosis in RA...
  22. pmc Prevalence of the metabolic syndrome in Latin America and its association with sub-clinical carotid atherosclerosis: the CARMELA cross sectional study
    Jorge Escobedo
    Medical Research Unit on Clinical Epidemiology, Mexican Social Security Institute, Mexico City, Mexico
    Cardiovasc Diabetol 8:52. 2009
    ..Limited information on its prevalence in Latin America is available. The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study included assessment of metabolic syndrome in 7 urban Latin American populations...
  23. pmc Association of vitamin D insufficiency with carotid intima-media thickness in HIV-infected persons
    Andy I Choi
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Clin Infect Dis 52:941-4. 2011
    ..If confirmed, these findings support a clinical trial of vitamin D supplementation to reduce cardiovascular events in HIV-infected persons...
  24. pmc An experimental study on the ultimate strength of the adventitia and media of human atherosclerotic carotid arteries in circumferential and axial directions
    Zhongzhao Teng
    Mathematical Sciences Department, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
    J Biomech 42:2535-9. 2009
    ..50+/-0.22). These measurements of the material strength limits for human atherosclerotic carotid arteries could be useful in improving computational models that assess plaque vulnerability...
  25. ncbi The carotid artery atherosclerosis burden and its relation to cardiovascular risk factors in black and white Africans with established rheumatoid arthritis: a cross-sectional study
    Ahmed Solomon
    Department of Rheumatology, Charlotte Maxeke Johannesburg Academic Hospital, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, PO Box 1012, Melville 2109, Johannesburg, South Africa
    J Rheumatol 39:1798-806. 2012
    ..We compared the carotid atherosclerosis burden and its relationships with cardiovascular (CV) risk factors between Africans with RA from a developing black and developed CV population...
  26. pmc Vascular biomarkers in the prediction of clinical cardiovascular disease: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10021, USA
    Hypertension 59:29-35. 2012
    ..These findings support the utility of separate assessment of focal atherosclerosis and intimal-medial thickness in epidemiological studies, trials, and risk stratification protocols...
  27. ncbi Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failure
    Minoru Yambe
    Second Department of Internal Medicine, Tokyo Medical University, Japan
    Hypertens Res 27:625-31. 2004
    ..Therefore, increased arterial stiffness is a possible simultaneous risk for atherosclerotic cardiovascular disease and diastolic heart failure in patients with hypertension...
  28. ncbi Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, USA
    Circulation 111:2768-75. 2005
    ..We have shown that MRI can accurately identify carotid intraplaque hemorrhage and precisely measure plaque volume. We tested the hypothesis that hemorrhage into carotid atheroma stimulates plaque progression...
  29. ncbi Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6226 persons: the Tromsø Study
    Stein Harald Johnsen
    Department of Neurology, University Hospital North Norway, N 9038 Tromsø, Norway
    Stroke 38:2873-80. 2007
    ..In this prospective, population-based study, we measured carotid IMT, total plaque area, and plaque echogenicity as predictors for first-ever myocardial infarction (MI)...
  30. ncbi Relationship between ankle-brachial index and carotid intima-media thickness in HIV-infected patients
    Felix Gutierrez
    Infectious Diseases Unit, Hospital General Universitario de Elche, Alicante, Spain
    AIDS 22:1369-71. 2008
    ..Ankle-brachial index was associated with carotid intima-media thickness. Patients with low ankle-brachial index, but not those with high ankle-brachial index, had high carotid intima-media thickness...
  31. ncbi Validation of 3D ultrasound vessel wall volume: an imaging phenotype of carotid atherosclerosis
    Micaela Egger
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Ultrasound Med Biol 33:905-14. 2007
    ..7% ICC = 0.85, rescan COV = 21.1% ICC = 0.88 and interscan variability, COV = 31.1%, ICC = 0.83), although absolute variances for both phenotypes were very similar (VWV = 90 mm3, TPV = 80 mm3)...
  32. ncbi Carotid atherosclerosis and chronic hepatitis C: a prospective study of risk associations
    Salvatore Petta
    Sezione di Gastroenterologia, Di Bi M I S, Universita di Palermo, Italia
    Hepatology 55:1317-23. 2012
    ..3%) with F3-F4 fibrosis (P = 0.008). By contrast, in patients >55 years the prevalence of carotid plaques was similar in those with or without severe fibrosis (25/43, 58.1% versus 22/43, 51.1%; P = 0.51)...
  33. ncbi Maximum carotid intima-media thickness improves the prediction ability of coronary artery stenosis in type 2 diabetic patients without history of coronary artery disease
    Yoko Irie
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Atherosclerosis 221:438-44. 2012
    ..However, it is unknown whether ultrasonic assessment of carotid atherosclerosis, including CIMT, improves the prediction ability for CAD over and above conventional coronary risk factors in the diabetic patients...
  34. pmc A candidate gene study revealed sex-specific association between the OLR1 gene and carotid plaque
    Liyong Wang
    Dr John T Macdonald Foundation, Department of Human Genetics, Miller School of Medicine, University of Miami, Clinical Research Building, Suite CRB 13, 1120 NW 14th Street, Miami, FL 33136, USA
    Stroke 42:588-92. 2011
    ..We sought to examine the sex-dependent associations between genes involved in lipid metabolism and carotid atherosclerotic plaque, a subclinical precursor of stroke...
  35. ncbi Impaired insulin sensitivity is an independent predictor of common carotid intima-media thickness in a population sample of elderly men
    M Wohlin
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Atherosclerosis 170:181-5. 2003
    ..In conclusion, this study is the first to establish impaired insulin sensitivity, measured by the euglycemic hyperinsulinemic clamp test, as an independent predictor of CCA-IMT in a population-based sample of elderly men...
  36. pmc Longitudinal predictors of progression of carotid atherosclerosis in rheumatoid arthritis
    Jon T Giles
    Columbia University, New York, New York, USA
    Arthritis Rheum 63:3216-25. 2011
    ..To explore predictors of change in measures of carotid atherosclerosis among rheumatoid arthritis (RA) patients without known cardiovascular disease (CVD) at baseline...
  37. ncbi Atherosclerotic plaque disruption induced by stress and lipopolysaccharide in apolipoprotein E knockout mice
    Mei Ni
    Shandong Univ Qilu Hospital, No 107, Wen Hua Xi Road, Jinan, Shandong 250012, P R China
    Am J Physiol Heart Circ Physiol 296:H1598-606. 2009
    ..Plasma fibrinogen levels were remarkably elevated in the stress and stress+LPS groups. In conclusion, stress- and LPS-costimulated apoE(-/-) mice provide a useful model for studies of plaque vulnerability and interventions...
  38. ncbi Sex differences in early carotid atherosclerosis (from the community-based Gutenberg-Heart Study)
    Christoph Sinning
    Department of Medicine 2, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Am J Cardiol 107:1841-7. 2011
    ..In young subjects without cardiovascular risk factors, normal values for IMT were lower in women compared with men. In contrast, in older subjects, gender differences in IMT became nonsignificant...
  39. ncbi Clinical implication of plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations in patients with advanced carotid atherosclerosis
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Athens, Greece
    Clin Chem Lab Med 48:1035-41. 2010
    ..Recent evidence further suggests that NGAL may play a crucial role in vascular remodeling and plaque instability during the development of atherosclerosis...
  40. ncbi Evidence-based treatment of carotid artery stenosis
    Kate C Young
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14620, USA
    Neurosurg Focus 30:E2. 2011
    ..Finally, the choice of revascularization technique is discussed with respect to symptom status. Based on current evidence, CAS should remain limited to specific indications...
  41. pmc The metabolic syndrome and progression of carotid atherosclerosis over 13 years. The Tromsø study
    Marit Herder
    Department of Community Medicine, University of Tromsø, Tromsø, Norway
    Cardiovasc Diabetol 11:77. 2012
    ..The metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease. In this study, we examine if metabolic syndrome predicts progression of atherosclerosis over 13 years...
  42. pmc Myeloid-related protein-8/14 is critical for the biological response to vascular injury
    Kevin Croce
    Director, Case Cardiovascular Center, Herman K Hellerstein Professor of Cardiovascular Research, Case Western Reserve University School of Medicine, Division of Cardiovascular Medicine, 11100 Euclid Ave, LKS 3001, Cleveland, OH 44106 5038, USA
    Circulation 120:427-36. 2009
    ..Beyond its serving as a risk marker, whether MRP-8/14 participates directly in vascular inflammation and disease remains unclear...
  43. ncbi Ultrasonic echolucent carotid plaques predict future strokes
    M L Grønholdt
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Circulation 104:68-73. 2001
    ..We tested prospectively the hypothesis that stroke development can be predicted by echolucency of carotid atherosclerotic plaques in previously symptomatic and asymptomatic patients...
  44. ncbi Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands, and Hopital Broussais Assistance Publique Hopitaux de Paris Faculte de Medecine Rene Descartes, France
    Eur Heart J 28:398-406. 2007
    ....
  45. ncbi Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy
    J David Spence
    Robarts Research Institute and University of Western Ontario, London
    Stroke 33:2916-22. 2002
    ..Carotid plaque area measured by ultrasound (cross-sectional area of longitudinal views of all plaques seen) was studied as a way of identifying patients at increased risk of stroke, myocardial infarction, and vascular death...
  46. pmc Carotid atherosclerosis predicts incident acute coronary syndromes in rheumatoid arthritis
    Matthew R Evans
    Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    Arthritis Rheum 63:1211-20. 2011
    ..We undertook this study to determine the extent to which ACS are associated with carotid atherosclerosis in RA...
  47. ncbi Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes
    Gian Paolo Fadini
    Department of Clinical and Experimental Medicine, Metabolic Division, University of Padova, Medical School, Padova, Italy
    Circ Res 108:1112-21. 2011
    ..Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in diabetes...
  48. pmc Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes
    Qin Li
    Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China
    Cardiovasc Diabetol 10:72. 2011
    ..We aimed to investigate whether elevated serum uric acid concentrations are associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in patients with type 2 diabetes...
  49. pmc Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: an in vivo MRI-based 3D fluid-structure interaction study
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Stroke 40:3258-63. 2009
    ..To test that hypothesis, 3D fluid-structure interaction models were constructed based on in vivo MRI data of human atherosclerotic carotid plaques to assess structural stress behaviors of plaques with and without rupture...
  50. ncbi Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly
    P Monica Lind
    Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
    Atherosclerosis 218:207-13. 2011
    ..Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study...
  51. ncbi Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis
    F J Nieto
    Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205
    Circulation 94:922-7. 1996
    ..Animal studies as well as clinical and cross-sectional epidemiological studies in humans have suggested a possible role of cytomegalovirus (CMV) and other herpesvirus infections in the development of cardiovascular disease...
  52. pmc The effect of cardiovascular risk factors on the longitudinal evolution of the carotid intima medial thickness in children with type 1 diabetes mellitus
    Robert Dalla Pozza
    Department of Pediatric Cardiology, Ludwig Maximilians University, Marchioninistr, 15, D 81377 Munich, Germany
    Cardiovasc Diabetol 10:53. 2011
    ..The aim of this prospective longitudinal study was to evaluate changes in carotid intima media thickness (cIMT) in children and adolescents with type 1 diabetes mellitus (T1DM) using standardized methods...
  53. ncbi Should we consider gestational diabetes a vascular risk factor?
    S Bo
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, Italy
    Atherosclerosis 194:e72-9. 2007
    ..Post-GDM women, despite being currently free from metabolic abnormalities, showed higher values of markers of endothelial dysfunction and IMT than controls, consistent with an increased future cardiovascular risk...
  54. pmc Tumor necrosis factor receptor levels are associated with carotid atherosclerosis
    Mitchell S Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, and the Columbia Presbyterian Medical Center of New York Presbyterian Hospital, New York, NY, USA
    Stroke 33:31-7. 2002
    ..We sought to determine whether tumor necrosis factor-alpha (TNF-alpha) and TNF receptor levels are associated with carotid plaque thickness...
  55. ncbi Metabolic syndrome and carotid intima media thickness in the Health 2000 Survey
    Kalle Sipilä
    Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
    Atherosclerosis 204:276-81. 2009
    ..The objective of this study was to examine metabolic syndrome as a determinant of CIMT in men and women and to compare the Framingham risk score (FRS) and metabolic syndrome as risk factors for increased carotid atherosclerosis...
  56. ncbi Increased intima-media thickness of the carotid artery wall, normal blood pressure profile and normal left ventricular mass in subjects with primary hyperparathyroidism
    V Nuzzo
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    Eur J Endocrinol 147:453-9. 2002
    ..Given the multiple influence of PHPT on the cardiovascular system, this study aimed to assess the effects of PHPT on blood pressure profile, and on features of the heart and arterial vessels in normotensive symptomless patients...
  57. pmc Carotid artery plaque thickness is associated with increased serum calcium levels: the Northern Manhattan study
    Mishaela R Rubin
    Department of Medicine, Columbia University College of Physicians and Surgeons, PH8W 864, 630 W 168th St, New York, NY 10032, USA
    Atherosclerosis 194:426-32. 2007
    ..We investigated the association between serum calcium and carotid plaque thickness, a powerful early predictor of clinical coronary and cerebrovascular events...
  58. ncbi Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase in
    Joost P G Sluijter
    Experimental Cardiology Laboratory, University Medical Center, Utrecht, The Netherlands
    Stroke 37:235-9. 2006
    ..We studied matrix metalloproteinases (MMP) 2, 8, and 9 and extracellular matrix metalloproteinase inducer (EMMPRIN) levels in relation to carotid atherosclerotic plaque characteristics...
  59. ncbi Incremental predictive value of carotid ultrasonography in the assessment of coronary risk in a cohort of asymptomatic type 2 diabetic subjects
    Sophie Bernard
    Department of Endocrinology, Diabetes, and Nutrition, Unité 11, 28 Ave Doyen Lépine, Hopital Cardiovasculaire Louis Pradel, 69003 Lyon Montchat, France
    Diabetes Care 28:1158-62. 2005
    ....
  60. ncbi Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats
    C Indolfi
    Division of Cardiology, University Federico II, and the National Cancer Institute, Naples, Italy
    Circulation 103:2980-6. 2001
    ..The mechanisms of increased neointimal hyperplasia after coronary interventions in diabetic patients are still unknown...
  61. ncbi Combined effects of hemoglobin A1c and C-reactive protein on the progression of subclinical carotid atherosclerosis: the INVADE study
    Dirk Sander
    Department of Neurology, Technical University of Munich, Munich, Germany
    Stroke 37:351-7. 2006
    ..We investigated the joint effects of both parameters on early carotid atherosclerosis progression and major vascular events in diabetic and nondiabetic subjects...
  62. pmc Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    AIDS 22:1615-24. 2008
    ..To assess the association of HIV infection, HIV disease parameters (including CD4+ T-cell counts, HIV viral load, and AIDS) and antiretroviral medication use with subclinical carotid artery atherosclerosis...
  63. ncbi Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study
    Markus Juonala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Circulation 112:1486-93. 2005
    ..Exposure to risk factors in childhood may have long-term influences on vascular function. We examined the relationship between risk factors identified in childhood and arterial elasticity assessed in adulthood...
  64. pmc Regression of target organ damage in children and adolescents with primary hypertension
    Mieczyslaw Litwin
    Department of Research, The Children s Memorial Health Institute, Warsaw, 04 730, Poland
    Pediatr Nephrol 25:2489-99. 2010
    ..137, β = 0.412, p = 0.03). Standard antihypertensive treatment lowered BP and led to regression of TOD in hypertensive children. Lean body mass increase and decrease in abdominal obesity correlated with TOD regression...
  65. ncbi Prognostic impact of fibrinogen in carotid atherosclerosis: nonspecific indicator of inflammation or independent predictor of disease progression?
    Schila Sabeti
    Department of Angiology, Medical University of Vienna, Austria
    Stroke 36:1400-4. 2005
    ..We investigated whether fibrinogen predicts future progression of carotid atherosclerosis, analyzing whether fibrinogen levels add to the prognostic information of other inflammatory parameters...
  66. ncbi Evaluation of postpartum carbohydrate intolerance and cardiovascular risk factors in women with gestational diabetes
    Baris Akinci
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey
    Gynecol Endocrinol 27:361-7. 2011
    ..Antepartum prediction of high risk subjects for the subsequent development of postpartum carbohydrate intolerance and metabolic syndrome seems to be vital to prevent cardiovascular outcomes...
  67. ncbi The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease
    Sammy Y Chan
    Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 42:1037-43. 2003
    ..The goal of this study was to determine the relative prognostic importance of noninvasive measures of endothelial function and atheroma burden in patients with coronary artery disease (CAD)...
  68. pmc Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries
    Stephane S Silvera
    Sinai Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Atherosclerosis 207:139-43. 2009
    ....
  69. ncbi Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged men
    T Skoog
    The Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Eur Heart J 23:376-83. 2002
    ....
  70. pmc Under-representation of women and ethnic minorities in vascular surgery randomized controlled trials
    Andrew W Hoel
    Division of Vascular Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Vasc Surg 50:349-54. 2009
    ..This study describes the reporting of gender and ethnicity data in vascular surgery RCTs and analyzes whether these studies adequately represent our diverse patient population...
  71. ncbi Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus
    Mary J Roman
    Division of Cardiology, Weill Medical College of Cornell University, The Hospital for Special Surgery, New York, NY 10021, USA
    N Engl J Med 349:2399-406. 2003
    ....
  72. pmc A negative correlation between human carotid atherosclerotic plaque progression and plaque wall stress: in vivo MRI-based 2D/3D FSI models
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
    J Biomech 41:727-36. 2008
    ..637). These pilot studies suggest that both lower PWS and lower FSS may contribute to continued plaque progression and should be taken into consideration in future investigations of diseases related to atherosclerosis...
  73. ncbi Evaluation of metabolic syndrome frequency and carotid artery intima-media thickness as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease
    Cem Aygun
    Department of Internal Medicine and Gastroenterology, Kocaeli University, F Kerim Gokay Cad, Erenkoy, Istanbul, Turkey
    Dig Dis Sci 53:1352-7. 2008
    ..The aim of this study was to evaluate metabolic syndrome (MetS) frequency and carotid artery intima-media thickness (IMT) as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease...
  74. pmc Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient study
    Dalin Tang
    Worcester Polytechnic Institute, Mathematical Sciences Department 100 Institute Road, Worcester, MA, USA
    Biomed Eng Online 8:15. 2009
    ..However, large-scale studies based on in vivo patient data combining mechanical stress analysis, plaque morphology and composition for carotid plaque vulnerability assessment are lacking in the current literature...
  75. pmc Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus
    David M Nathan
    DCCT EDIC Research Group at Box NDIC DCCT, Bethesda, MD 20892, USA
    N Engl J Med 348:2294-303. 2003
    ..We examined the progression of carotid intima-media thickness, a measure of atherosclerosis, in a population with type 1 diabetes...
  76. ncbi Oxidized haemoglobin as antigenic target of cell-mediated immune reactions in patients with carotid atherosclerosis
    Elisabetta Profumo
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Autoimmun Rev 8:558-62. 2009
    ..Our findings implicate oxidized Hb as a possible antigenic target of cell-mediated immune responses contributing to inflammation in the pathogenesis of carotid atherosclerosis...
  77. ncbi Determinants of carotid intima-medial thickness in an urban Australian Aboriginal population
    Pamela J Bradshaw
    School of Population Health University of Western Australia, Nedlands, WA 6009, Australia
    Atherosclerosis 192:218-23. 2007
    ..We studied the determinants of carotid atherosclerosis in urban-dwelling Australian Aboriginals at high risk of atherosclerotic mortality and morbidity...
  78. pmc Risk factors for subclinical carotid atherosclerosis among current smokers
    Heather M Johnson
    University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Prev Cardiol 13:166-71. 2010
    ..001) were independently associated with carotid plaque presence (model χ(2) =210.7, P<.001). The association between pack-years and carotid plaque was stronger in women (OR, 1.09 per 10 pack-years, P(interaction) =.018)...
  79. ncbi Three-dimensional ultrasound of carotid atherosclerosis: semiautomated segmentation using a level set-based method
    E Ukwatta
    Biomedical Engineering Graduate Program and Robarts Research Institute, The University of Western Ontario, London, Ontario N6A 3K7, Canada
    Med Phys 38:2479-93. 2011
    ..The main purpose of this work was to develop and evaluate a semiautomated segmentation algorithm for delineating the MAB and LIB of the carotid artery from 3D US images...
  80. ncbi Predictors of carotid intima-media thickness progression in young adults: the Bogalusa Heart Study
    Heather M Johnson
    Division of Cardiovascular Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
    Stroke 38:900-5. 2007
    ..Although risk factors for the progression of atherosclerosis in middle-aged and elderly adults are well known, they are less well understood in young adults. CIMT is a validated measure of subclinical atherosclerosis...
  81. ncbi Multi-sequence in vivo MRI can quantify fibrous cap and lipid core components in human carotid atherosclerotic plaques
    R A Trivedi
    University Department of Radiology, Addenbrooke s Hospital, Cambridge, UK
    Eur J Vasc Endovasc Surg 28:207-13. 2004
    ..Risk of thrombo-embolic stroke is thought to be better reflected by carotid plaque composition than by luminal stenosis. We set out to determine whether high resolution MRI was a valid method of quantifying plaque components in vivo...
  82. ncbi Measurement of intima-media thickness vs. carotid plaque: uses in patient care, genetic research and evaluation of new therapies
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, ON, Canada N6G 2V2
    Int J Stroke 1:216-21. 2006
    ..IMT should not be called 'atherosclerosis': the phenotype being assessed should be specified...
  83. ncbi Early carotid atherosclerosis and cardiac diastolic abnormalities in hypertensive subjects
    G Parrinello
    Department of Internal Medicine, University of Palermo, Italy
    J Hum Hypertens 18:201-5. 2004
    ..This approach might improve the prognostic stratification of hypertensive subjects and it might be suitable to recognize the subset of patients at a higher risk of cardiovascular disease or events early...
  84. ncbi Carotid atherosclerosis and the risk factors in early postmenopausal Chinese women
    Ruby H Y Yu
    Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong
    Maturitas 63:233-9. 2009
    ..To describe the distribution of intima-media thickness (IMT) and the prevalence of plaque by carotid segments, walls and sides, and to examine their associated risk factors in asymptomatic, early postmenopausal Chinese women in Hong Kong...
  85. ncbi Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study
    Damiano Baldassarre
    Department of Pharmacological Sciences, University of Milan, Italy
    Eur Heart J 31:614-22. 2010
    ..This paper reports the results of the baseline analyses aimed at identifying the major determinants of increased carotid IMT (C-IMT)...
  86. pmc Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice
    Qiongzhen Li
    Department of Radiology and the Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 39:166-73. 2008
    ..Quantitative trait locus analysis was performed on an intercross between B6.apoE(-/-) and C3H.apoE(-/-) mice to determine genetic factors contributing to variation in the phenotype...
  87. pmc Early signs of atherosclerosis are associated with insulin resistance in non-obese adolescent and young adults with type 1 diabetes
    Björn Rathsman
    Karolinska Institutet, Department of Clinical Science and Education, Sachs Childrens Hospital, Södersjukhuset AB, Stockholm, SE 118 83, Sweden
    Cardiovasc Diabetol 11:145. 2012
    ..We aimed to explore the role of insulin sensitivity (Si) as an early factor of atherosclerosis in young type 1 diabetes vs. non-diabetic subjects...
  88. ncbi Trends, complications, and mortality in peripheral vascular surgery
    Roman Nowygrod
    Columbia Weill Cornell Division of Vascular Surgery, Columbia University, New York, NY, USA
    J Vasc Surg 43:205-16. 2006
    ....
  89. ncbi Elevated high-density lipoprotein cholesterol levels are protective against plaque progression: a follow-up study of 1952 persons with carotid atherosclerosis the Tromsø study
    Stein Harald Johnsen
    Institute of Community Medicine, University of Tromsø, N 9037 Tromsø, Norway
    Circulation 112:498-504. 2005
    ..In this prospective, population-based ultrasound study, we investigated how HDL cholesterol relates to carotid plaque progression...
  90. ncbi Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathology
    Aloke V Finn
    CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 30:177-81. 2010
    ..Moreover, in most cases measures of plaque area or volume are generally considered better predictors of an inflammatory process consistent with atherosclerotic disease rather than intimal medial thickness...
  91. ncbi Association of elevated fibrinogen and C-reactive protein levels with carotid lesions in patients with newly diagnosed hypertension or type II diabetes
    Egle Corrado
    Department of Internal Medicine, Cardiovascular and Nephro Urological Diseases, University of Palermo, Palermo, Italy
    Arch Med Res 37:1004-9. 2006
    ..Inflammation may be important for accelerated progression of atherosclerosis in patients with hypertension or diabetes, but few studies included subjects with early stages of atherosclerosis such as those with asymptomatic carotid lesions...
  92. ncbi Subclinic atherosclerosis and cardiovascular risk factors in HIV-infected children: PERI study
    Isabela de C B Giuliano
    Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Coron Artery Dis 19:167-72. 2008
    ....
  93. pmc Genetic and nongenetic sources of variation in phospholipid transfer protein activity
    Gail P Jarvik
    Department of Medicine Division of Medical Genetics, University of Washington, Seattle, WA, USA
    J Lipid Res 51:983-90. 2010
    ..These results demonstrate that PLTP activity is strongly influenced by PLTP region polymorphisms and metabolic factors...
  94. ncbi Cholesteryl ester transfer protein and hepatic lipase gene polymorphisms: effects on hepatic mRNA levels, plasma lipids and carotid atherosclerosis
    Selma M Soyal
    Department of Laboratory Medicine, Paracelsus Medical University, Mullner Hauptstr 48, 5020 Salzburg, Austria
    Atherosclerosis 216:374-80. 2011
    ..We studied associations of CETP-Taq1B and -514C>T-LIPC polymorphisms with hepatic mRNA levels, and their combined effects on plasma lipids and carotid atherosclerosis...
  95. ncbi Hepatic steatosis is associated with an increased risk of carotid atherosclerosis
    Henry Volzke
    Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Walther Rathenau Str 48, D 17487 Greifswald, Germany
    World J Gastroenterol 11:1848-53. 2005
    ..The aim of the present study has been to investigate those relationships...
  96. pmc Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke
    Jaywant P Parmar
    Department of Radiology, University of Virginia Health System, Charlottesville, USA
    Circulation 122:2031-8. 2010
    ..Although generally accepted, the relationship between cerebral thromboembolism and in situ atherosclerotic plaque morphology has never been directly observed noninvasively in the acute setting...
  97. ncbi The phosphodiesterase inhibitor cilostazol induces regression of carotid atherosclerosis in subjects with type 2 diabetes mellitus: principal results of the Diabetic Atherosclerosis Prevention by Cilostazol (DAPC) study: a randomized trial
    Naoto Katakami
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Circulation 121:2584-91. 2010
    ..However, the efficacy and usefulness of 2 different antiplatelet drugs, aspirin and cilostazol, in the progression of carotid intima-media thickening are unknown...
  98. ncbi Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome
    Hyeon Chang Kim
    Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Atherosclerosis 204:521-5. 2009
    ..We examined the association between NAFLD and carotid intima-media thickness (IMT) according to the presence of metabolic syndrome (MetS)...
  99. pmc Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study
    Tuhina Neogi
    Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite X 200, Boston, MA 02118, USA
    J Rheumatol 36:378-84. 2009
    ....
  100. ncbi Elevation of serum aminotransferase activity increases risk of carotid atherosclerosis in patients with non-alcoholic fatty liver disease
    Chia Chi Wang
    Department of Hepatology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan
    J Gastroenterol Hepatol 24:1411-6. 2009
    ..The aim of the present study was to investigate whether NAFLD patients with ALT elevation had a higher risk of carotid atherosclerosis...
  101. ncbi Histopathology of carotid atherosclerotic disease
    Renu Virmani
    International Registry of Pathology, Inc, Gaithersburg, Maryland, USA
    Neurosurgery 59:S219-27; discussion S3-13. 2006
    ....

Research Grants68

  1. Structure-Function Assessment of Carotid Disease by MR
    Felix Wehrli; Fiscal Year: 2004
    ....
  2. Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical Sequelae
    Chun Yuan; Fiscal Year: 2013
    ..Moreover, the identification of increased neurological ischemia (silent or overt) despite aggressive medical therapy may substantially alter the management in patients with IPH across all levels of stenosis. ..
  3. Assessing Microstructure of Carotid Disease with MRI/MRS
    Ronald Wolf; Fiscal Year: 2006
    ..Plaque lipid profile and calcium content will be studied as a means to characterize the lesion and evaluate the association between plaque characteristics and patients' symptomatology. ..
  4. Assessing the Impact of Rare Polymorphism at CRP on CRP Levels & Atherosclerosis
    Christopher S Carlson; Fiscal Year: 2010
    ....
  5. GENCAC - North Carolina Field Center
    Lynne Wagenknecht; Fiscal Year: 2004
    ..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
  6. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2009
    ..abstract_text> ..
  7. Epidemiology of Carotid Intima-Medial Thickness (IMT) in Atherosclerosis
    Joseph Polak; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  8. BIOBEHAVIORAL FACTORS IN ATHEROSCLEROTIC PROGRESSION
    Thomas Kamarck; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  9. 3T Atherosclerotic MRI and Carotid Artery Scoring System
    Chun Yuan; Fiscal Year: 2009
    ....
  10. Progression of sub-clinical Atherosclerosis
    Joseph Polak; Fiscal Year: 2009
    ..This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers. ..
  11. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  12. Inflammatory Genomics in Human Carotid Artery Disease
    GAIL JARVIK; Fiscal Year: 2006
    ..Genes that are implicated in disease may eventually allow targeted therapy. ..
  13. Carotid Artery Disease Following Neck Irradiation in Ch*
    Kathleen Meeske; Fiscal Year: 2006
    ..abstract_text> ..
  14. Epidemiology of IGF and Cardiovascular Events
    Robert Kaplan; Fiscal Year: 2005
    ....
  15. Procoagulants in Aging CARDIA Participants
    David Green; Fiscal Year: 2009
    ....
  16. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
  17. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
  18. Advanced NeuroImaging for Acute Stroke Treatment
    Max Wintermark; Fiscal Year: 2007
    ..Invited junior scientists, for whom funding is requested, were selected based on merit. [unreadable] [unreadable] [unreadable]..
  19. Prediction and Progression of Carotid Artery Disease
    GAIL JARVIK; Fiscal Year: 2009
    ..Aim 3: Pathway evaluation of oxidative loci and phenotypes in prediction of CAAD. ..
  20. Mechanisms of Atherosclerosis and CVD in HIV+ Women
    Robert Kaplan; Fiscal Year: 2009
    ..This investigation will have major implications for the development of strategies to predict, prevent, or reverse atherosclerosis in HIV- infected women. ..
  21. Genetic Determinants of Subclinical Carotid Disease
    Tatjana Rundek; Fiscal Year: 2008
    ..3. To explore a newly developed statistical method to evaluate the overall genetic effects from all candidate genes to obtain "whole-pathway" effects. ..
  22. Pittsburgh Mind-Body Center-II
    Karen Matthews; Fiscal Year: 2008
    ..Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible. ..
  23. Nanoparticles for Molecular MRI of Atherosclerosis
    Zahi Fayad; Fiscal Year: 2008
    ..These studies will provide the basis for future advances in experimental studies of atherosclerogenesis and new clinical applications of non-invasive, in vivo MR imaging of atherosclerotic lesions. [unreadable] [unreadable] [unreadable]..
  24. CELL SURFACE METABOLISM OF MACROPHAGE DERIVED APO E
    Theodore Mazzone; Fiscal Year: 2001
    ..In this Specific Aim we will more thoroughly examine the metabolism of LDL and ALDL as it is influenced by the cell surface pool of macrophage derived apo E. ..
  25. Contraceptive in Women with Prior Gestational Diabetes
    Anny Xiang; Fiscal Year: 2005
    ..The observational results will also be important to the design of future direct comparisons of different forms of contraception in this high-risk population. ..
  26. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
  27. MICROSPECT IN TUMOR IMAGING
    HARRY STRAUSS; Fiscal Year: 2003
    ..At SKI, an ideal setting for such an instrument, the microSPECT will be an invaluable adjunct to the rapidly expanding small-animal imaging program. ..
  28. Photothrombotic Brain Infarction and Epileptogenesis
    Kevin Kelly; Fiscal Year: 2005
    ..abstract_text> ..
  29. ER beta selective agonist coronary protection-menopause
    R Hermsmeyer; Fiscal Year: 2005
    ..The new ERbetaA is to be contrasted with PremPro(r) (oral conjugated equine estrogens plus medroxyprogesterone acetate) which failed to provide cardiovascular protection in the Women's Health Initiative. ..
  30. Lipoprotein Metabolism 2008 Gordon Research Conference
    Robert Hegele; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  31. PROGRESSION OF AORTIC ATHEROMA IN STROKE/TIA PATIENTS
    Souvik Sen; Fiscal Year: 2004
    ..Designing of future placebo controlled prospective studies aimed at investigating measures that may be used to treat AA in stroke/TIA patients. ..
  32. Obesity subtypes, adiponectin and incident stroke among postmenopausal women
    Rachel Wildman; Fiscal Year: 2008
    ..Therefore, this application could have a significant impact on stroke prevention as it relates to appropriate treatment indications for obesity. ..
  33. Middle Cerebral and Common Artery Occlusion and Poststroke Epilepsy
    Kevin Kelly; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  34. COGNITIVE AND CEREBROVASCULAR SEQUELAE OF HYPERTENSION
    J Jennings; Fiscal Year: 2004
    ..Successful completion will clarify a) how one major disease of aging reduces intellectual functioning and b) permit a rational choice of clinical regimen to treat this disease while minimizing neuropsychological side effects. ..
  35. Epidemiology of Subclinical Atherosclerosis in SLE
    Lisabeth Scalzi; Fiscal Year: 2008
    ..SLE, an inflammatory and immune-dysregulated disease, may provide an ideal model of CVD. ..
  36. Study of Carotid Occlusion and Neurocognition (RECON)
    RANDOLPH MARSHALL; Fiscal Year: 2009
    ....
  37. Molecular genetics of glucose homeostasis and fat
    Donald Bowden; Fiscal Year: 2009
    ..g. create an "ultra high density" SNP map of the associated chromosomal region. These new SNPs will be genotyped on the IRASFS DNAs to identify the trait defining alleles. ..
  38. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2003
    ....
  39. PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSION
    PATRIC STANTON; Fiscal Year: 2008
    ..The long-term regulation of transmitter release has far-reaching importance to normal synaptic processing dynamics, and controlling pathologic glutamate release during injury or disease. ..
  40. Macrophage Cholesterol Metabolism and ApoE Synthesis
    Theodore Mazzone; Fiscal Year: 2007
    ..abstract_text> ..
  41. Identification of diabetes genes on human chromosome 20
    Donald Bowden; Fiscal Year: 2009
    ..g. insulin resistance, (3-cell function, etc.). Confirmation of association in multiple populations will justify a more detailed molecular genetic analysis similar to that being proposed for PTPN1. ..
  42. THE EFFECT OF HMG COA REDUCTASE INHIBITORS ON CBF
    COLIN DERDEYN; Fiscal Year: 2002
    ..Positive results from these experiments would support further investigation of a potentially important mechanism of stroke protection applicable to all patients with atherosclerotic coronary and cerebrovascular disease. ..
  43. CCR2 in Atherosclerosis and Monocyte Trafficking
    Israel F Charo; Fiscal Year: 2010
    ..Completion of these studies will deepen our understanding of the role of chemokines in monocyte homeostasis and the importance of macrophage activation in atherosclerotic plaque instability. ..
  44. 2005 Atherosclerosis Gordon Conference
    Israel Charo; Fiscal Year: 2005
    ..abstract_text> ..
  45. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  46. RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
    Evelyn Talbott; Fiscal Year: 2005
    ..The investigators state that this study has the potential to identify the determinants of early SCA in this high-risk group of women and has important implications for primary as well as secondary prevention. ..
  47. Atheroclerosis in rheumatoid arthritis cohort
    INMACULADA DEL RINCON; Fiscal Year: 2005
    ..This would ultimately lengthen life expectancy and improve the quality of life of people with inflammatory diseases. ..
  48. MOEMS device for fluorescence spectroscopy of tissues and cells
    Laura Marcu; Fiscal Year: 2006
    ..The device will widely be applied to various biomedical instruments that require wavelength differentiation and selection. ..
  49. Non-viral controllable gene delivery for neuroprotection
    JAMES HECKER; Fiscal Year: 2007
    ..Neuroprotection strategies designed for pre-operative use will also have significant application for attenuation of secondary injury following stroke, brain or spinal cord trauma, or neurodegenerative diseases. ..
  50. Vascular Protection in Acute Ischemic Stroke
    Susan Fagan; Fiscal Year: 2005
    ..Collectively, the successful completion of the research summarized in this proposal can be expected to contribute to the development of methods to make reperfusion safer, and therefore more accessible, to human stroke patients. ..
  51. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
  52. 2007 Vascular Cell Biology Gordon Research Conference
    Bradford Berk; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. Biochemical Heterogeneity in Morbidly Obese Women in the WHI Observational Study
    Rachel Mackey; Fiscal Year: 2008
    ..This will be the first epidemiology study to specifically focus on morbidy obesity Class III unselected for weight reduction, i.e. bariatric surgery, in black and white women. ..
  54. Fish Oil Intake, Biomarkers and Change in Lung Function
    R Barr; Fiscal Year: 2008
    ..Use of this existing cohort with previously collected blood samples will provide relatively cost-effective results about this potentially promising and safe therapy for COPD. ..
  55. Protein Kinase C in Macrophage Activation
    MICHELLE LENNARTZ; Fiscal Year: 2006
    ..Defining the mechanisms by which PKC transduces the phagocytic signal is critical to our understanding of host defense and the defects that result in autoimmune diseases. ..
  56. Trends in blood pressure in relation to obesity
    Rebecca Din Dzietham; Fiscal Year: 2005
    ..Research findings would lead to more refined mechanistic studies for ultimately better tailored interventions. ..
  57. In vivo multichannel fluorescent imaging
    Umar Mahmood; Fiscal Year: 2007
    ....
  58. Spatial epidemiology of diabetes in the SEARCH for Diabetes in Youth Study
    ANGELA LIESE; Fiscal Year: 2009
    ..This effort may provide novel leads for subsequent etiologic studies of pediatric diabetes and will assist health care planners in identifying geographic areas in particular need of health services resources. ..
  59. Carotid Atherosclerosis (MRI) Progression Study (CAMP)
    JOHN CROUSE; Fiscal Year: 2008
    ..abstract_text> ..
  60. STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGION
    Ralph Sacco; Fiscal Year: 2007
    ..abstract_text> ..
  61. MR Spectroscopy of SIV Brain Injury
    Ramon Gonzalez; Fiscal Year: 2009
    ..Specific Aim 2. Determine the severity of CNS injury by in vivo &ex vivo MRS and immunohistochemistry in different brain regions, and determine the levels of perivascular MPs in those regions. ..
  62. Inflammatory markers in CVD and OP in SLE women
    ELISA RHEW; Fiscal Year: 2006
    ..The project outlined in this proposal will provide a strong foundation for achieving my ultimate goal of becoming an independent clinical investigator. [unreadable] [unreadable]..
  63. In Vivo Assessment of AAA Biomechanics with Dynamic Wall Properties
    ENDER FINOL; Fiscal Year: 2008
    ..This methodology is expected to greatly enhance the presurgical planning capabilities of vascular surgeries and endovascular therapies in the future management of cardiovascular diseases. [unreadable] [unreadable] [unreadable]..
  64. FAT REDISTRIBUTION AND METABOLIC CHANGE IN HIV INFECTION
    Carl Grunfeld; Fiscal Year: 2006
    ..The results will provide essential information on the risk of atherosclerosis and its contributors to aid in patient care, policy and future research. [unreadable] [unreadable] [unreadable]..
  65. PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
    Ramon Gonzalez; Fiscal Year: 2002
    ..abstract_text> ..