Genomes and Genes
Summary: A broad category of disorders characterized by impairment of blood flow in the arteries and veins which supply the brain. These include CEREBRAL INFARCTION; BRAIN ISCHEMIA; HYPOXIA, BRAIN; INTRACRANIAL EMBOLISM AND THROMBOSIS; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; and VASCULITIS, CENTRAL NERVOUS SYSTEM. In common usage, the term cerebrovascular disorders is not limited to conditions that affect the cerebrum, but refers to vascular disorders of the entire brain including the DIENCEPHALON; BRAIN STEM; and CEREBELLUM.
Publications253 found, 100 shown here
- High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European citiesPaola Michelozzi
Department of Epidemiology Local Health Authority Rome E, Rome, Italy
Am J Respir Crit Care Med 179:383-9. 2009..Episode analyses of heat waves have documented a comparatively higher impact on mortality than on morbidity (hospital admissions) in European cities. The evidence from daily time series studies is scarce and inconsistent...
- Vascular pathology in the aged human brainLea Tenenholz Grinberg
Department of Neurology, University of California San Francisco, 305 Parnassus Avenue, San Francisco, CA 94143, USA
Acta Neuropathol 119:277-90. 2010....
- Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disordersIsidro Salcedo
Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Br J Pharmacol 166:1586-99. 2012..Herein, we review the physiological role of GLP-1 in the nervous system, focused towards the potential benefit of GLP-1R stimulation as an immediately translatable treatment strategy for acute and chronic neurological disorders...
- Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's diseaseRobert D Bell
Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
Acta Neuropathol 118:103-13. 2009..The data reviewed here support an essential role of neurovascular and BBB mechanisms in contributing to both, onset and progression of AD...
- White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusionMasunari Shibata
Department of Neurology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507 Japan
Stroke 35:2598-603. 2004..We have successfully established a mouse model of chronic cerebral hypoperfusion that may provide new strategies for the molecular analysis of cerebrovascular WM lesions...
- All-cause mortality associated with atypical and conventional antipsychotics among nursing home residents with dementia: a retrospective cohort studyRosa Liperoti
Centro di Medicina dell Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8 0168 Rome, Italy
J Clin Psychiatry 70:1340-7. 2009..We conducted a retrospective cohort study to compare the risk of death associated with atypical and conventional antipsychotics in a large population of nursing home residents with dementia...
- Circulating vitamin D, calcium and risk of cerebrovascular disease: a systematic review and meta-analysisRajiv Chowdhury
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Eur J Epidemiol 27:581-91. 2012..Conversely, higher circulating calcium concentration is associated with an increased risk of cerebrovascular disease...
- Cerebrovascular disorders: molecular insights and therapeutic opportunitiesErik Storkebaum
Molecular Neurogenetics Laboratory, Max Planck Institute for Molecular Biomedicine, Muenster, Germany
Nat Neurosci 14:1390-7. 2011..These genetic insights offer alternative therapeutic options, some of which are being evaluated in the clinic...
- Reversible cerebral vasoconstriction syndromes: analysis of 139 casesAneesh B Singhal
Department of Neurology, Massachusetts General Hospital, Boston, 02114, USA
Arch Neurol 68:1005-12. 2011..To compare the clinical, laboratory, and imaging features of patients with reversible cerebral vasoconstriction syndromes evaluated at 2 academic centers, compare subgroups, and investigate treatment effects...
- Mitochondrion-specific antioxidants as drug treatments for Alzheimer diseaseHector H Palacios
Department of Biology, College of Sciences, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249 1664, USA
CNS Neurol Disord Drug Targets 10:149-62. 2011....
- The Essen stroke risk score predicts recurrent cardiovascular events: a validation within the REduction of Atherothrombosis for Continued Health (REACH) registryChristian Weimar
Department of Neurology, University of Duisburg Essen, Essen, Germany
Stroke 40:350-4. 2009..We aimed to validate the ESRS in a large cohort of outpatients with previous transient ischemic attack or stroke from the REduction of Atherothrombosis for Continued Health (REACH) Registry...
- Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonographyR J Adams
Department of Neurology, Medical College of Georgia, Augusta 30912 3200, USA
N Engl J Med 339:5-11. 1998..We used transcranial Doppler ultrasonography to identify children with sickle cell anemia who were at high risk for stroke and then randomly assigned them to receive standard care or transfusions to prevent a first stroke...
- A clinical comparison of definite moyamoya disease between South Korea and JapanK Ikezaki
Department of Neurosurgery, Kyushu University Faculty of Medicine, Fukuoka, Japan
Stroke 28:2513-7. 1997..The goal of the present study was to clarify whether South Korean patients with moyamoya disease have clinical features similar to those of Japanese patients...
- Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysisChristoph Wanner
Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
N Engl J Med 353:238-48. 2005..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
- Transcranial color doppler study for reversible cerebral vasoconstriction syndromesShih Pin Chen
Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
Ann Neurol 63:751-7. 2008..Reversible cerebral vasoconstriction syndromes (RCVS) are characterized by thunderclap headaches and reversible cerebral vasoconstrictions. No systematic studies on cerebral hemodynamics have been published...
- Prior polyvascular disease: risk factor for adverse ischaemic outcomes in acute coronary syndromesDeepak L Bhatt
VA Boston Healthcare System and Brigham and Women s Hospital, Boston, MA, USA
Eur Heart J 30:1195-202. 2009....
- Treatment of vascular risk factors is associated with slower decline in Alzheimer diseaseYan Deschaintre
Universite Lille Nord de France, INSERM UMR 744, Institut Pasteur de Lille, 1 rue Calmette, 59019 Lille Cedex, France
Neurology 73:674-80. 2009..The aim of this observational study was to evaluate whether the treatment of VRF is associated with a slower cognitive decline in patients who have AD without cerebrovascular disease (CVD)...
- Brain hypoperfusion: a critical factor in vascular dementiaGustavo C Roman
University of Texas Health Science Center at San Antonio and the Audie L Murphy Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, San Antonio, USA
Neurol Res 26:454-8. 2004..Recognition of the susceptibility of elderly subjects to cerebral lesions induced by hypoperfusion should result in appropriate preventive measures and better treatment...
- Incidence and short-term prognosis of transient ischemic attack in a population-based studyDawn Kleindorfer
Department of Emergency Medicine, University of Cincinnati, Ohio, USA
Stroke 36:720-3. 2005..We present the incidence and short-term prognosis of TIA within a large population with a significant proportion of minorities with out-of-hospital TIA...
- MRI white matter hyperintensities: three-year follow-up of the Austrian Stroke Prevention StudyR Schmidt
Department of Neurology, Institute of Medical Biochemistry, Karl Franzens University, Graz, Austria
Neurology 53:132-9. 1999..To determine the rate, clinical predictors, and cognitive consequences of MRI white matter hyperintensity evolution over 3 years...
- Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular diseaseD Mungas
Department of Neurology, School of Medicine, University of California, Davis, USA
Neurology 59:867-73. 2002..To examine volumetric MRI correlates of longitudinal cognitive decline in normal aging, AD, and subcortical cerebrovascular brain injury (SCVBI)...
- Increased arterial stiffness is independently related to cerebrovascular disease and aneurysms of the abdominal aorta: the Second Manifestations of Arterial Disease (SMART) StudyJ M Dijk
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnummer Str 6 131, PO Box 85060, 3508 BA Utrecht, The Netherlands
Stroke 35:1642-6. 2004..Arterial stiffness is a risk factor for stroke and myocardial infarction. We investigated whether carotid arterial stiffness is related to other localizations of manifest arterial disease...
- Neuroimaging in cerebrovascular disorders: measurement of cerebral physiology after stroke and assessment of stroke recoveryJames M Mountz
Department of Radiology, Division of Nuclear Medicine, University of Alabama at Birmingham Medical Center, Birmingham, AL 35249 6835, USA
Semin Nucl Med 33:56-76. 2003..The value of these results on rehabilitation strategy, including possible criteria for the use of facilitatory versus compensatory approaches, is analyzed...
- Community-based study of stroke incidence in the Valley of Aosta, Italy. CARe-cerebrovascular Aosta Registry: years 2004-2005Giovanni Corso
Stroke Unit, Department of Neurology, Ospedale Regionale, Aosta, Italy
Neuroepidemiology 32:186-95. 2009....
- Risk of dementia in MCI: combined effect of cerebrovascular disease, volumetric MRI, and 1H MRSK Kantarci
Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Neurology 72:1519-25. 2009..To investigate the combined ability of hippocampal volumes, 1H magnetic resonance spectroscopy (MRS) metabolites, and cerebrovascular disease to predict the risk of progression to dementia in mild cognitive impairment (MCI)...
- A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiencyPaolo Zamboni
Vascular Diseases Center, University of Ferrara, Ferrara, Italy
J Vasc Surg 50:1348-58.e1-3. 2009..CCSVI is strongly associated with multiple sclerosis (MS). This study evaluated the safety of CCSVI endovascular treatment and its influence on the clinical outcome of the associated MS...
- Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascular events versus other antipsychoticsSanford Finkel
Medical Affairs at Council for Jewish Elderly, and the University of Chicago Medical School, IL, USA
Int Psychogeriatr 17:617-29. 2005..The objective was to determine whether risperidone is associated with an increased risk of CVEs relative to other commonly considered alternative treatments...
- Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging StudyRita Peila
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Diabetes 51:1256-62. 2002..6, 1.5-29.6). Type 2 diabetes is a risk factor for AD and VsD. The association between diabetes and AD is particularly strong among carriers of the APOE epsilon4 allele. The neuropathological data are consistent with the clinical results...
- Trends, predictors, and outcomes of cerebrovascular events related to percutaneous coronary intervention: a 16-year single-center experienceScott J Hoffman
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
JACC Cardiovasc Interv 4:415-22. 2011..We sought to determine trends, predictors, in-hospital and long-term outcomes of cerebrovascular events (CVE) related to percutaneous coronary intervention (PCI) over a 16-year period...
- Distinct imaging patterns and lesion distribution in posterior reversible encephalopathy syndromeW S Bartynski
Department of Radiology, Division of Neuroradiology, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
AJNR Am J Neuroradiol 28:1320-7. 2007..We evaluated lesion distribution with CT and MR in a large cohort of patients who experienced PRES to comprehensively assess the imaging patterns identified...
- Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementiaEric E Smith
Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Arch Neurol 65:94-100. 2008..To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline and dementia...
- Patient skin dose during neuroembolization by multiple-point measurement using a radiosensitive indicatorS Suzuki
Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan
AJNR Am J Neuroradiol 29:1076-81. 2008..The purpose of this research was to evaluate the patient's entrance skin dose (ESD) during neuroembolizations in 6 institutions...
- Do in vivo experimental models reflect human cerebral small vessel disease? A systematic reviewAtticus H Hainsworth
Centre for Clinical Neuroscience, Division of Cardiac and Vascular Sciences, St George s University of London, London, UK
J Cereb Blood Flow Metab 28:1877-91. 2008..The most-used model was the stroke-prone spontaneously hypertensive rat (SHR-SP). No model described all features of the human disease. The optimal choice of model depends on the aspect of pathophysiology being studied...
- Hypertension and cerebral diffusion tensor imaging in small vessel diseaseRob A R Gons
Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Stroke 41:2801-6. 2010..Diffusion tensor imaging provides measures of structural integrity...
- Fish consumption and the incidence of cerebrovascular diseaseJukka Montonen
Department of Health and Functional Capacity, National Public Health Institute, Mannerheimintie 166, FIN 00300, Helsinki, Finland
Br J Nutr 102:750-6. 2009..The relationship between fish consumption and stroke risk is not straightforward. How the fish is prepared for consumption may play an important role, affecting the association...
- Alzheimer’s disease, cerebrovascular disease, and the β-amyloid cascadeKie Honjo
L C Campbell Cognitive Neurology Research Unit Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada
Can J Neurol Sci 39:712-28. 2012..In this review, we review the role of vascular factors and Aβ, underlining that vascular risk factor management may be important for AD prevention and treatment...
- 4-D Imaging in cerebrovascular disorders by using 320-slice CT: feasibility and preliminary clinical experienceRandolf Klingebiel
Department of Neuroradiology, Charite, University Medicine Berlin, Berlin, Germany
Acad Radiol 16:123-9. 2009The authors report study protocols and initial clinical experience in assessing patients with acute and chronic cerebrovascular disorders using the recently introduced technique of volume computed tomography (VCT).
- 5-year outcomes following percutaneous coronary intervention with drug-eluting stent implantation versus coronary artery bypass graft for unprotected left main coronary artery lesions the Milan experienceAlaide Chieffo
Interventional Cardiology Unit, Department of Cardio Thoracic and Vascular Diseases, San Raffaele Scientific Institute, Milan, Italy
JACC Cardiovasc Interv 3:595-601. 2010....
- Dietary fats, cerebrovasculature integrity and Alzheimer's disease riskR Takechi
School of Public Health, Curtin Health Innovation Research Institute, Australian Technology Network Centre for Metabolic Fitness, Curtin University of Technology, Bentley Campus, Kent Street, Perth 6102, Australia
Prog Lipid Res 49:159-70. 2010..Clearly, delineating the mechanisms by which dietary fats increase AD risk may be informative in developing new strategies for prevention and treatment of AD...
- Cerebrovascular disorders in childrenJohn Kylan Lynch
Neuroepidemiology Branch, National Institute of Neurological Disorders and Stroke, NIH DHHS, Building 10, Room 5S220, 10 Center Drive, MSC 1447, Bethesda, MD 20892 1447, USA
Curr Neurol Neurosci Rep 4:129-38. 2004b>Cerebrovascular disorders are an important cause of mortality and chronic morbidity in children. International incidence rates for childhood stroke (ie, from 30 days to 18 years of age) have ranged from 1.3 to 13 per 100,000 children...
- Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic miceHiroshi Kitaguchi
Department of Neurology, Kyoto University, Sakyo ku, Kyoto 606 8504, Japan
Brain Res 1294:202-10. 2009..Taken together, chronic cerebral hypoperfusion increased Abeta fibrils and induced Abeta deposition in the intracellular compartment and, therefore, may accelerate the pathological changes of Alzheimer's disease...
- Genetics of cerebrovascular disordersJames F Meschia
Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
Mayo Clin Proc 80:122-32. 2005..This article reviews the clinical and genetic features of some mendellan and mitochondrial disorders associated with ischemic stroke, hemorrhagic stroke, and cerebrovascular malformations...
- Dilatation of the Virchow-Robin space is a sensitive indicator of cerebral microvascular disease: study in elderly patients with dementiaTufail F Patankar
Institutions Imaging Science and Biomedical Engineering, School of Medicine, University of Manchester, UK
AJNR Am J Neuroradiol 26:1512-20. 2005..The aim of our study was to test the hypothesis that dilatation of VRS is associated with subcortical vascular dementia...
- Urban air pollution and emergency admissions for cerebrovascular diseases in Taipei, TaiwanChang Chuan Chan
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Rm 722, 7F, No 17, Xu Zhou Road, Taipei 100, Taiwan, ROC
Eur Heart J 27:1238-44. 2006..This study was designed to evaluate the association between urban air pollutants and emergency admissions for cerebrovascular diseases...
- Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediatorsNarayan R Bhat
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurochem 115:551-62. 2010....
- Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer diseaseGjumrakch Aliev
The Microscopy Research Center and Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA
Neurotox Res 5:491-504. 2003....
- Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disordersRyuichi Ohkubo
Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima, Japan
J Neurol Sci 198:31-5. 2002..Although the number of CVD patients in the present study was too small to make a final conclusion, mt5178C might be one of the genetic factors to be considered in Japanese patients with CVD...
- Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonistNektaria Nicolakakis
Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
J Neurosci 28:9287-96. 2008....
- Cardiovascular epidemiology in the Asia-Pacific regionG L Khor
Department of Nutrition and Health Sciences, Faculty, of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang
Asia Pac J Clin Nutr 10:76-80. 2001..Thus, monitoring the impact of these changes on cardiovascular risks is essential to enable the implementation of appropriate strategies towards countering the rise of CVD mortality...
- Females with Fabry disease frequently have major organ involvement: lessons from the Fabry RegistryWilliam R Wilcox
Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd SSB, Los Angeles, CA 90048, USA
Mol Genet Metab 93:112-28. 2008..Thus, females with FD have a significant risk for major organ involvement and decreased QoL. Females should be regularly monitored for signs and symptoms of FD, and considered for enzyme replacement therapy...
- White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention studyReinhold Schmidt
Department of Neurology, Medical University Graz, Austria
Ann Neurol 58:610-6. 2005....
- Vascular basis of Alzheimer's pathogenesisJ C de La Torre
Division of Neuropathology, University of California San Diego, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
Ann N Y Acad Sci 977:196-215. 2002....
- Vitamin D status and the risk of cardiovascular disease deathAnnamari Kilkkinen
National Institute for Health and Welfare, Helsinki, Finland
Am J Epidemiol 170:1032-9. 2009..These findings need to be replicated in other populations. To demonstrate a causal link between vitamin D and CVD, randomized controlled trials are required...
- Work-related cerebro-cardiovascular diseases in KoreaDae Seong Kim
Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon, Korea
J Korean Med Sci 25:S105-11. 2010..The strategic approach is needed essentially because CVDs are common, serious and preventable diseases which lead to economic burden...
- Hypertension and cerebrovascular damageFranco Veglio
University of Turin, Italy
Atherosclerosis 205:331-41. 2009..Cerebral parenchymal and functional damages have to be considered together to make medical intervention more incisive...
- Alzheimer disease as a vascular disorder: nosological evidenceJ C de La Torre
Department of Neuropathology, University of California at San Diego, CA 92026, USA
Stroke 33:1152-62. 2002..The main stumbling block in the clinical management and in the search for a cure of Alzheimer disease (AD) is that the cause of this disorder has remained uncertain until now...
- Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementiaA Joutel
INSERM U25, Faculte de Medecine Necker Enfants Malades, Paris, France
Nature 383:707-10. 1996..We have identified mutations in CADASIL patients that cause serious disruption of this gene, indicating that Notch3 could be the defective protein in CADASIL patients...
- The burden of paediatric stroke and cerebrovascular disorders in CroatiaJ Lenicek Krleza
Department of Laboratory Diagnostics, University School of Medicine and Children s Hospital Zagreb, Klaiceva 16, Zagreb 10000, Croatia
Int J Stroke 4:390-4. 2009..Obtained data will contribute to better understanding of paediatric stroke in Croatia and will provide a base for the establishment of the national referral center and national pediatric stroke registry...
- Cerebral atrophy in cerebrovascular disordersEric Jouvent
Department of Neurology, Hopital Lariboisiere, Assistance Pulique Hôpitaux de Paris and Université Paris VII, Paris, France
J Neuroimaging 20:213-8. 2010..Recent data suggest that brain atrophy is prominent in various cerebrovascular disorders. Studies of the effects of different cerebrovascular magnetic resonance imaging (MRI) markers and of the ..
- Repetitive use of intra-arterial verapamil in the treatment of reversible cerebral vasoconstriction syndromeKris F French
Department of Neurology and Clinical Neurosciences, Clinical Neurosciences Center, University of Utah Hospitals and Clinics, 175 N Medical Drive East, Salt Lake City 84132, UT, USA
J Clin Neurosci 19:174-6. 2012....
- Arterial spin-labeled MR perfusion imaging: clinical applicationsJeffrey M Pollock
Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Magn Reson Imaging Clin N Am 17:315-38. 2009..The appearance of pathology is affected significantly by the ASL techniques used. Familiarity with the available sequence parameter options and the common appearances of pathology facilitates perfusion interpretation...
- Is Chlamydia pneumoniae seropositivity associated with atherothrombotic cerebrovascular infarction?Seyed Mohammad Alavi
Infectious disease ward, Razi Hospital, Ahvaz Joundishapour University of Medical Sciences, Ahvaz, Iran
J Infect Public Health 2:96-9. 2009..Since these studies have reported controversial results, we performed this study to identify whether Cp-immunoglobulin was associated with atherothrombotic cerebrovascular infarction (ACI) in Iranian patients...
- Carotid plaque morphology and cerebrovascular eventsG Carra
Department of Vascular Medicine, Internal Medicine and General Medicine, University of Padua, Civil Hospital, Castelfranco Veneto TV, Italy
Int Angiol 22:284-9. 2003..Our aim was to evaluate the relationship between plaque morphology, progression of stenosis, and the development of new cerebrovascular events...
- Cerebrovascular disease and dementiaChiadi U Onyike
Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int Rev Psychiatry 18:423-31. 2006..Our knowledge of the risk factors has also provided opportunities for the primary and secondary prevention of vascular dementia, and indicates promising avenues for research...
- The North American Symptomatic Carotid Endarterectomy Trial : surgical results in 1415 patientsG G Ferguson
John P Robarts Research Institute, London, Ontario, Canada gary
Stroke 30:1751-8. 1999..This study reports the surgical results in those patients who underwent carotid endarterectomy in the North American Symptomatic Carotid Endarterectomy Trial (NASCET)...
- Long-term safety and cognitive effects of galantamine in the treatment of probable vascular dementia or Alzheimer's disease with cerebrovascular diseaseA F Kurz
Department of Psychiatry and Psychotherapy, Technische Universitaet Munchen, Munich, Germany
Eur J Neurol 10:633-40. 2003..Long-term (up to 24 months) galantamine therapy in patients with VaD and AD with CVD is well tolerated and associated with prolonged maintenance of cognitive function...
- Age and apoE associations with complex pathologic features in Alzheimer's diseaseGregory A Jicha
Department of Neurology, Mayo Clinic, Rochester, MN, Jacksonville, FL, United States
J Neurol Sci 273:34-9. 2008....
- Genetic variation in white matter hyperintensity volume in the Framingham StudyLarry D Atwood
Department of Neurology, Boston University School of Medicine, 715 Albany Street, B 609, Boston, Mass 02118, USA
Stroke 35:1609-13. 2004..73). We investigated heritability of WMH in a family-based sample of the Framingham Heart Study for sex differences and the impact of age...
- Risk estimations, risk factors, and genetic variants associated with Alzheimer's disease in selected publications from the Framingham Heart StudyGalit Weinstein
Department of Neurology, Boston University School of Medicine, Boston, MA 20008, USA
J Alzheimers Dis 33:S439-45. 2013..The second is a large meta-analysis GWA study of AD, in which novel loci of AD susceptibility were found. Together, these findings demonstrate the FHS multi-directional efforts in investigating dementia and AD...
- Role of methylenetetrahydrofolate reductase gene (MTHFR) 677C>T polymorphism in pediatric cerebrovascular disordersHamza Alsayouf
Division of Child Neurology, The Ohio State University, Columbus, Nationwide Children s Hospital, OH 43205, USA
J Child Neurol 26:318-21. 2011..However, the data suggest that the MTHFR TT genotype may influence migraine susceptibility in children because there was a higher proportion of migraine patients (28.6%) with the MTHFR TT homozygous genotype...
- Calcium and magnesium in drinking water and risk of death from cerebrovascular diseaseC Y Yang
School of Public Health, Kaohsiung Medical College, Taiwan, Republic of China
Stroke 29:411-4. 1998..This report examines whether calcium and magnesium in drinking water are protective against cerebrovascular disease...
- Prior peripheral arterial disease and cerebrovascular disease are independent predictors of adverse outcome in patients with acute coronary syndromes: are we doing enough? Results from the Orbofiban in Patients with Unstable Coronary Syndromes-ThrombolysiGad Cotter
Cardiology Institutes of Assaf Harofeh Medical Center, Zerifin, Israel
Am Heart J 145:622-7. 2003....
- Two-year vascular event rates in patients with symptomatic cerebrovascular disease: the REACH registryNarayanaswamy Venketasubramanian
Division of Neurology, National University Hospital, Singapore
Cerebrovasc Dis 32:254-60. 2011..We describe 2-year vascular outcomes among symptomatic CeVD patients from the REduction of Atherothrombosis for Continued Health (REACH) Registry...
- Comparison of coronary artery bypass surgery and percutaneous drug-eluting stent implantation for treatment of left main coronary artery stenosisAnthony J White
Cedars Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California 90048, USA
JACC Cardiovasc Interv 1:236-45. 2008..The purpose of this study was to compare outcomes for drug-eluting stents (DES) and coronary artery bypass graft (CABG) surgery in patients with unprotected left main coronary artery (ULMCA) stenosis...
- Progression of cerebral white matter lesions -- clinical and radiological considerationsChristian Enzinger
Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A 8036 Graz, Austria
J Neurol Sci 257:5-10. 2007..Power calculations based on quantitative data of the Austrian Stroke Prevention Study (ASPS) suggest that such studies would be feasible...
- Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH RegistryShinichiro Uchiyama
Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
J Neurol Sci 287:45-51. 2009..9 were significant predisposing factors for stroke. Patients with CVD and co-existing atherothrombotic diseases had a high risk of recurrent events, including events arising in other vascular beds than originally diagnosed...
- The blood-brain barrier/neurovascular unit in health and diseaseBrian T Hawkins
Department of Medical Pharmacology, University of Arizona College of Medicine, Tucson, Arizona, USA
Pharmacol Rev 57:173-85. 2005..Therefore, understanding how BBB TJ might be affected by various factors holds significant promise for the prevention and treatment of neurological diseases...
- Cerebral hyperperfusion syndrome after percutaneous transluminal stenting of the craniocervical arteriesP M Meyers
Department of Radiology, University of California at San Francisco, USA
Neurosurgery 47:335-43; discussion 343-5. 2000..To our knowledge, there are no previous studies evaluating the incidence of hyperperfusion syndrome after percutaneous transluminal angioplasty/stenting...
- Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's diseaseHiroshi Kitaguchi
Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
Neurosci Lett 417:128-31. 2007..Cortical microvascular changes in AD and their absence in BD may indicate a role of beta amyloid for the microvessel pathology in AD...
- Quantitative cerebral blood flow determinations in acute ischemic stroke. Relationship to computed tomography and angiographyA D Firlik
Department of Neurological Surgery, University of Pittsburgh Medical Center, PA 15213, USA
Stroke 28:2208-13. 1997....
- Prediction of cerebral hyperperfusion syndrome after carotid stenting: a cerebral perfusion computed tomography studyYing Chi Tseng
Department of Radiology, Cathay General Hospital, Taipei, Taiwan, Republic of China
J Comput Assist Tomogr 33:540-5. 2009..The objective of this study was to evaluate the role of cerebral perfusion computed tomography (CT) in predicting cerebral hyperperfusion syndrome (CHS) after carotid stenting...
- Size fractionate particulate matter, vehicle traffic, and case-specific daily mortality in Barcelona, SpainL Perez
Center for research in environmental epidemiology CREAL, Dr Aiguader 88, 08003 Barcelona, Spain
Environ Sci Technol 43:4707-14. 2009..Vehicle traffic PM, generated by combustion and noncombustion processes, should be considered in air pollution mitigation strategies in urban areas...
- Advances in molecular genetics and pathology of cerebrovascular disordersR N Kalaria
Wolfson Research Centre, Institute for Health of the Elderly, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
Trends Neurosci 24:392-400. 2001..in molecular genetics has enabled the dissection of several autosomal dominantly inherited forms of cerebrovascular disorders. Mutations in diverse genes might induce pathological changes in intracranial vessels, resulting in ..
- Vascular pathologies and cognition in a population-based cohort of elderly peopleMalee S Fernando
Neuropathology, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield, E Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Neurol Sci 226:13-7. 2004..Using an MRI strategy to image formalin-fixed brain slices, the study shows that white matter lesions (WMLs) are common (94% overall frequency) and are an independent risk factor for dementia using multivariable analysis...
- Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health StudyW T Longstreth
Department of Neurology, University of Washington, Seattle, USA
Stroke 27:1274-82. 1996..Our aim was to identify potential risk factors for and clinical manifestations of white matter findings on cranial MRI in elderly people...
- Agalsidase-beta therapy for advanced Fabry disease: a randomized trialMaryam Banikazemi
Mount Sinai School of Medicine of New York University, New York, New York, USA
Ann Intern Med 146:77-86. 2007..Fabry disease (alpha-galactosidase A deficiency) is a rare, X-linked lysosomal storage disorder that can cause early death from renal, cardiac, and cerebrovascular involvement...
- Alzheimer disease and cerebrovascular pathology: an updateK A Jellinger
Ludwig Boltzmann Institute of Clinical Neurobiology, Otto Wagner Hospital, Vienna, Austria
J Neural Transm 109:813-36. 2002..Further studies will help to elucidate the risk factors and impact of cerebrovascular lesions on the development and progression of dementia in AD...
- Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trialTimo Erkinjuntti
Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
Lancet 359:1283-90. 2002..We investigated the effects of galantamine in patients with a diagnosis of probable vascular dementia or Alzheimer's disease combined with cerebrovascular disease...
- The prevalence of peripheral arterial disease in high risk subjects and coronary or cerebrovascular patientsPavel Poredos
Department of Vascular Diseases, University Medical Centre, Ljubljana, Slovenia
Angiology 58:309-15. 2007..In conclusion, our findings confirm a high prevalence of both symptomatic and asymptomatic PAD in patients at high cardiovascular risk and its association with both CAD and CVD...
- Brain perfusion abnormalities in patients with euthyroid autoimmune thyroiditisM Piga
Nuclear Medicine, Department of Medical Sciences M Aresu, University of Cagliari, Cagliari, Italy
Eur J Nucl Med Mol Imaging 31:1639-44. 2004..Sixteen adult patients with HT entered this study following informed consent...
- CNS manifestations of Fabry's diseaseAndreas Fellgiebel
Department of Psychiatry, University of Mainz, Mainz, Germany
Lancet Neurol 5:791-5. 2006..Cerebral vasculopathy, confirmed by neuropathological, neuroradiological, and functional studies, occurs commonly and leads to ischaemic cerebrovascular events at an early age...
- Cerebral small-vessel disease and decline in information processing speed, executive function and memoryNiels D Prins
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
Brain 128:2034-41. 2005..Our results suggest that in older people cerebral small-vessel disease may contribute to cognitive decline by affecting information processing speed and executive function...
- Prognosis and management of patients with acute coronary syndrome and polyvascular diseaseIgnacio Ferreira-Gonzalez
Area del Cor, Servicio de Cardiologia, Hospital Vall d Hebron, Barcelona, Espana
Rev Esp Cardiol 62:1012-21. 2009..To assess prognosis and patterns of care in patients with acute coronary syndrome and peripheral arterial disease (PAD), cerebrovascular disease or both (i.e., polyvascular disease) in everyday clinical practice...
- Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in miceRuna Araya
Yamada Research Unit, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Neurobiol Dis 24:334-44. 2006..The M5 receptor may represent an attractive novel therapeutic target to ameliorate memory deficits caused by impaired cerebrovascular function...
- Cerebrovascular disordersJames S Hutchison
Department of Critical Care and Pediatrics, Hospital for Sick Children, and Interdepartmental Division of Critical Care, Faculty of Medicine, University of Toronto, Toronto, Canada
Semin Pediatr Neurol 11:139-46. 2004..Children with acute stroke should be rapidly transported to and cared for in a pediatric center with a specialized stroke team or access to acute stroke protocols...
- Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloidM E Calhoun
Department of Neuropathology, Institute for Pathology, University of Basel, CH 4003 Basel, Switzerland
Proc Natl Acad Sci U S A 96:14088-93. 1999..APP23 mice on an App-null background developed a similar degree of both plaques and CAA, providing further evidence that a neuronal source of APP/Abeta is sufficient to induce cerebrovascular amyloid and associated neurodegeneration...
- Cerebrovascular disease and strokeJ Pappachan
Department of Paediatric Intensive Care, Child Health Directorate, Southampton General Hospital, Southampton, UK
Arch Dis Child 93:890-8. 2008Stroke and cerebrovascular disorders are important causes of morbidity and mortality in children; they are already amongst the top 10 causes of childhood death and are probably increasing in prevalence...
- Relationship of vascular risk to the progression of Alzheimer diseaseB Borroni
Neurology 68:1083-4; author reply 1084. 2007
- Incidence of dementia and associated risk factors in Japan: The Osaki-Tajiri ProjectKenichi Meguro
Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Japan
J Neurol Sci 260:175-82. 2007..A comprehensive system including CDR, cognitive tests, and MRI, is recommended in community-based health policy planning...
- AD brain pathology: vascular origins? Results from the HAAS autopsy studyLenore J Launer
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C 309 Bethesda, MD 20892, USA
Neurobiol Aging 29:1587-90. 2008..Our study suggests the burden of vascular and AD type lesions are independent of each other, and are consistent with an additive effect of the two types of lesions on cognitive impairment...
- Evolution of cerebral arteriopathies in childhood arterial ischemic strokeNasuda Danchaivijitr
Department of Radiology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Ann Neurol 59:620-6. 2006..To investigate evolution of cerebral arteriopathy in children with arterial ischemic stroke (AIS) and its influence on recurrence...
- CHRONIC INTERMITTENT HYPOXIA, NEUROVASCULAR DYSFUNCTION AND STROKECostantino Iadecola; Fiscal Year: 2013..Ultimately, the results of the proposed studies may suggest novel mechanism-based approaches to prevent or treat the deleterious effects of this highly prevalent condition. ..
- Eicosanoids and carbon monoxide in neonatal cerebral microcirculationALIE JOSEPH KANU; Fiscal Year: 2012..advance our knowledge of cerebral blood flow regulation and identify targets for the development of new techniques as well as therapeutic agents for the long-term treatment of cerebrovascular disorders in newborns. (End of Abstract)
- Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular AgingFarzaneh A Sorond; Fiscal Year: 2010..for clinical trials of HIF-1 activators in a number of hypoxic-ischemic geritaric disorders, especially cerebrovascular disorders such as ischemia and vascular cognitive impairment, which pose a significant health burden in our aging ..
- Exercise as a novel strategy to target methamphetamine-induced cerebrovascular toMichal Toborek; Fiscal Year: 2013..evidence that even moderate exercise can significantly contribute to brain regeneration in chronic cerebrovascular disorders. PUBLIC HEALTH RELEVANCE: Methamphetamine (METH) abuse results in a long-term impairment of vascular ..
- Calcium signaling in the cerebrovascular unit in health and diseaseMark T Nelson; Fiscal Year: 2013..normal brain function;by extension, dysfunction of Ca^* signaling dynamics contributes to cerebrovascular disorders. Each project studies overlapping elements of the biological system to form a whole...
- Non-contrast 4-D Dynamic MRA in Arteriovenous Malformation (AVM)DANNY JIONG JIONG WANG; Fiscal Year: 2013..It will be useful not only for evaluation of AVMs, but also for other cerebrovascular disorders such as steno-occlusive diseases and cerebral aneurysms. !
- Arterial Spin Labeled Perfusion MRI in Acute Ischemic StrokeDANNY JIONG JIONG WANG; Fiscal Year: 2013..It is a translational project with the goal to develop and validate an entirely noninvasive and quantitative MRI method for routine clinical evaluation of AIS as well as other cerebrovascular disorders.
- Vascular Smooth Muscle Notch Signaling in Arterial Patterning and FunctionAaron Proweller; Fiscal Year: 2013..abstract_text> ..
- POLYDRUG ABUSE IN WOMENNANCY MELLO; Fiscal Year: 2000..Polydrug abuse and cocaine dependence are also associated with life-threatening cardiovascular and cerebrovascular disorders, abnormalities of reproductive function and compromised fetal development...
- ACUTE BRAIN INJURY AFTER SUBARACHNOID HEMORRHAGEJoshua Bederson; Fiscal Year: 2001..is to develop a program of laboratory research that parallels the clinical problems of patients with cerebrovascular disorders. One of the most important of these is the lack of treatment options for patients who have suffered a ..
- Effects of VEGF on Brain Tissue in vitroJEFFREY ROSENSTEIN; Fiscal Year: 2004..As an angiogenic factor VEGF could have potential use in cerebrovascular disorders but may also have trophic effects upon astroglia and neurons...
- NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTIONWILLIAM MAYHAN; Fiscal Year: 2006..While there is evidence, which suggests that smoking is a risk factor for the pathogenesis of cerebrovascular disorders, including stroke, mechanisms, which contribute to the development of cerebrovascular disorders remain ..
- A SYNERGIUM ON STROKE: Spurring Progress in Challenging TimesMarc Fisher; Fiscal Year: 2010..bring together key opinion leaders to discuss a range of important topics related to the entire gamut of cerebrovascular disorders. For each of the 7 themes to be discussed, the 3 co-chairs will invite 5 additional contributors of ..
- Metabolic Effects of Newer Antipsychotics in Older PtsDilip Jeste; Fiscal Year: 2009..experienced multidisciplinary team of investigators (including experts in metabolic, cardiovascular, and cerebrovascular disorders), and infrastructure support provided by an NIMH-funded Advanced Center for Interventions and Services ..
- A New Collagen Expressed Primarily in Brain TissueJEANNE MYERS; Fiscal Year: 2002..Furthermore, neurodegenerative diseases such as Alzheimer's, Parkinson's, cerebrovascular disorders, together with epilepsy and multiple sclerosis, constitute a major class of devastating conditions which ..
- CELLULAR BIOLOGY OF BRAIN MICROVESSELSSami Harik; Fiscal Year: 1992..The proposed research may provide scientific bases for rational therapy of cerebrovascular disorders, metabolic encephalopathies and neurodegenerative disorders such as Parkinson's Disease.
- MICROVASCULAR PERICYTES--CONTROL OF CEREBRAL BLOOD FLOWIra Herman; Fiscal Year: 1992..matrix protein and mRNA metabolism modulate cerebrovascular cell behavior, but may ultimately reveal the molecular and cellular mechanisms that control the anomalous flow of blood seen in patients with cerebrovascular disorders.
- PETT IN CEREBROVASCULAR DISORDERS OF NEWBORN INFANTDENIS ALTMAN; Fiscal Year: 1991....
- Transgenic Murine Model of Brain Vascular MalformationGuo Yuan Yang; Fiscal Year: 2004..This non-tumor angiogenesis rodent preparation will serve as a model of disordered human cerebral angiogenesis, leading relatively quickly to the ability to test new therapeutic approaches for cerebrovascular disorders.
- MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORSRaj Kalaria; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- GENETIC STUDIES OF ANEURYSMAL SUBARACHNOID HEMORRHAGEMark Alberts; Fiscal Year: 2003..This research project combined with the PI's background and expertise provide a wide range of patient-oriented mentorship opportunities in clinical and genetic research...
- Tryptophan Metabolism, Genes, and Major DepressionDavid Steffens; Fiscal Year: 2007..Results from this study will help inform future treatment studies using genetics and metabolomic technology. [unreadable] [unreadable] [unreadable]..
- Frontotemporal degeneration: a basis for clinical trialsDavid Knopman; Fiscal Year: 2006..abstract_text> ..
- Neuroimaging in Depression Treatment StudiesYvette Sheline; Fiscal Year: 2006..abstract_text> ..
- Treatment Outcome of Vascular DepressionYvette Sheline; Fiscal Year: 2005..The proposed trial will provide information of value to the practitioner and also provide data to build a more comprehensive model of the prognostic impact of frontal-subcortical brain changes on the outcome of late-life depression. ..
- Vascular Depression: Longitudinal FollowupYvette I Sheline; Fiscal Year: 2010..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
- PET Amyloid Plaque Imaging in Late Life DepressionYvette Sheline; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Novel Brain Neuroimaging Markers of Age-Related Mobility ImpairmentCaterina Rosano; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- 3D CEREBRAL VESSEL LOCATION FOR SURGICAL PLANNINGElizabeth Bullitt; Fiscal Year: 2008..unreadable] [unreadable]..
- Pilot Trial of Metformin in Amnestic MCIJose A Luchsinger; Fiscal Year: 2010....
- Prostanoid Receptors and Ischemic Brain InjuryCostantino Iadecola; Fiscal Year: 2010..abstract_text> ..
- Protein S: Neurovascular Protection in StrokeBerislav V Zlokovic; Fiscal Year: 2010..B. Berk (Rochester) (Tyro 3 RTK-Akt signaling) and Dr. M. Chopp (Henry Ford) (rat stroke model). The results will provide mechanistic insights and test therapeutic agents that may be translated to improved therapy for ischemic stroke. ..
- Global vs. Focal Neuroimaging Markers of Dementia RiskCaterina Rosano; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Role of COX-2 Gene Expression in Ischemic Brain DamageCostantino Iadecola; Fiscal Year: 2010..abstract_text> ..
- MIDCAREER INVESTIGATOR AWARD IN CEREBROVASCULAR RESEARCHLarry Goldstein; Fiscal Year: 2004....
- Alzheimer's ABeta, Apolipoproteins & Blood-Brain BarrierBerislav Zlokovic; Fiscal Year: 2004....
- 3D Image Guided Endovascular SurgeryElizabeth Bullitt; Fiscal Year: 2006..Indeed, the methods to be developed under this proposal have the potential to change how endovascular procedures are performed throughout the body. ..
- Anticholinergic Drugs, Cognitive Deficits & Normal AgingRobert Nebes; Fiscal Year: 2006..We will also examine whether the decrements that anticholinergic drugs produce in higher-level cognitive abilities are mediated through decreases in working memory, processing speed or inhibitory efficiency. ..
- AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUPLarry Goldstein; Fiscal Year: 2002..However the treatment duration will be increased to a total of 10 sessions. ..
- 3D CEREBRAL VESSEL LOCATION FOR SURGICAL PLANNINGElizabeth Bullitt; Fiscal Year: 2001..We propose a number of studies to evaluate the accuracy and utility of our approach, and we also propose new visualization methods to indicate the uncertainty of our symbolic descriptions of image objects. ..
- AGING, WHITE MATTER HYPERINTENSITIES & COGNITIVE DECLINERobert Nebes; Fiscal Year: 2001....
- Vascular factors, amyloid beta, and Alzheimer's diseaseJose Luchsinger; Fiscal Year: 2004..abstract_text> ..
- Noninvasive assessment of tumor malignancyElizabeth Bullitt; Fiscal Year: 2010....
- Neurovascular Coupling in HypertensionCostantino Iadecola; Fiscal Year: 2004..The results of these studies will enhance our understanding of the effects of hypertension on the brain and may provide new insights into treatment strategies aimed at counteracting these detrimental actions. ..
- AGING BRAIN--CEREBROVASCULAR MECHANISM & AMYLOID BETABerislav Zlokovic; Fiscal Year: 2003..abstract_text> ..
- HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTSSHARI WALDSTEIN; Fiscal Year: 2008..abstract_text> ..
- EXPERIMENTAL NEUROGENIC HYPERTENSION PROGRAMCostantino Iadecola; Fiscal Year: 2008..The proposed studies are relevant to human diseases, such as hypertension-induced cognitive dysfunction, cardiovascular complications of sleep apnea, and cardiovascular diseases in post-menopausal women. ..
- MENTAL DISORDERS OF AGING--ANTIINFLAMMATION IN ADGary Small; Fiscal Year: 2003....
- Internat'l symposium:vascular neuroeffector mechanismsSUE DUCKLES; Fiscal Year: 2002..We anticipate that all aspects of this conference will help to foster development of new directions and collaborations in the field. ..
- GENETIC EPIDEMIOLOGY OF AGING IN A MULTIETHNIC COMMUNITYRichard Mayeux; Fiscal Year: 2002....
- PORPHYRIA AND HUMAN HEME BIOSYNTHESISRobert J Desnick; Fiscal Year: 2010..Viable CEP mice should permit studies of the disease pathophysiology and future therapeutic endeavors. ..
- Neuroprotection with serpins during cardiac surgeryRichard A Jonas; Fiscal Year: 2010..The final phase will study mechanisms of vascular protection afforded by aprotinin. The proposed study has the potential to reduce the risk of brain injury in children and adults undergoing heart surgery. ..
- Cerebrovascular risk factors and late-life suicideSAU MAN CHAN; Fiscal Year: 2007..The correlation between clinical and radiopathological CVRFs as well as the relationship between burden of CVRFs and impaired ECFs will be worked out by correlation statistics. ..
- Conference on the Diagnosis of Multiple System AtrophySid Gilman; Fiscal Year: 2006..This conference will assist with early diagnosis by developing new guidelines for diagnosis using newly available imaging and neuropathological criteria. [unreadable] [unreadable] [unreadable]..
- Latent Mobility Abnormalities and DisabilityJoe Verghese; Fiscal Year: 2006..unreadable] [unreadable]..
- Hemodynamics and Outcome in Pediatric Brain InjuryMONICA VAVILALA; Fiscal Year: 2007..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
- National Assessment of the Mortality and Morbidity Effects of Tropospheric OzoneMichelle L Bell; Fiscal Year: 2010..The goal of this work is to provide policy-makers, scientists, and the public with a better understanding of how ozone affects health in order to aid more effective decisions regarding protection of human health. ..
- Heme oxygenase and cerebral vascular injuryHelena Parfenova; Fiscal Year: 2008..Better understanding of the mechanisms of postictal cerebral vascular dysfunction is needed to improve the long-term neurological outcome in human newborns. ..
- Pilot Study of an Internet-based Cognitive Stimulation Program in AIDSJames Becker; Fiscal Year: 2008..If this is true, then it means that people with mild forms of cognitive impairment may be able to help themselves to get better. [unreadable] [unreadable] [unreadable] [unreadable]..
- Hemodynamic predictors of brain and cognitive agingNaftali Raz; Fiscal Year: 2005....
- Use of Herbs and Dietary Supplements in Four EthnicitiesAnnette Fitzpatrick; Fiscal Year: 2005..It may also be possible to test associations of specific herb/supplement use with specific clinical/subclinical conditions should adequate power be available. ..
- Cognitive reserve and age-related brain changesAdam Brickman; Fiscal Year: 2005..Results from the study will provide important insights into the normal aging process and will yield valuable information towards understanding the underpinnings of age-associated pathologies. ..
- TISSUE VIABILITY IN STROKE BY SODIUM MR IMAGINGKeith Thulborn; Fiscal Year: 2002..abstract_text> ..
- Cerebrovascular mechanisms of ischemic injury in diabetesAdviye Ergul; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..