carotid stenosis

Summary

Summary: Narrowing or stricture of the internal, common, or external carotid artery, most often as a result of atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce thrombus formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a transient ischemic attack (ISCHEMIC ATTACK, TRANSIENT) or CEREBROVASCULAR ACCIDENT. Emboli which travel to the eye may manifest as AMAUROSIS FUGAX (temporary blindness). (From Adams et al., Principles of Neurology, 6th ed, pp822-3)

Top Publications

  1. ncbi Carotid artery stenosis: gray-scale and Doppler US diagnosis--Society of Radiologists in Ultrasound Consensus Conference
    Edward G Grant
    Department of Radiology, University of Southern California, Keck School of Medicine, USC University Hospital, 1500 San Pablo St, Los Angeles, CA 90033, USA
    Radiology 229:340-6. 2003
  2. pmc Stenting versus endarterectomy for treatment of carotid-artery stenosis
    Thomas G Brott
    Mayo Clinic, Griffin 304, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    N Engl J Med 363:11-23. 2010
  3. ncbi Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion
    H Markus
    Clinical Neuroscience, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Brain 124:457-67. 2001
  4. ncbi In vivo MRI-based 3D mechanical stress-strain profiles of carotid plaques with juxtaluminal plaque haemorrhage: an exploratory study for the mechanism of subsequent cerebrovascular events
    Z Teng
    University Department of Radiology, University of Cambridge, Level 5, Box 218, Addenbrooke s Hospital, Hills Rd, Cambridge CB2 0QQ, UK
    Eur J Vasc Endovasc Surg 42:427-33. 2011
  5. pmc Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
    Jörg Ederle
    Institute of Neurology, University College London, Box 6, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Lancet 375:985-97. 2010
  6. ncbi Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 361:107-16. 2003
  7. ncbi Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study
    Willem E Hellings
    Department of Vascular Surgery, Experimental Cardiology Laboratory, University Medical Center Utrecht, Heidelberglaan 100, Suite G02 523, 3584CX Utrecht, The Netherlands
    Circulation 121:1941-50. 2010
  8. ncbi Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men
    Navneet Singh
    Department of Diagnostic Imaging, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview St, Toronto, ON, Canada M4N 3M5
    Radiology 252:502-8. 2009
  9. ncbi Cerebral hemodynamics and cognitive performance in bilateral asymptomatic carotid stenosis
    Clotilde Balucani
    Department of Neurology, University of Perugia, Perugia, Italy
    Neurology 79:1788-95. 2012
  10. ncbi Cognitive and physical performance in patients with asymptomatic carotid artery disease
    Nancy C Landgraff
    Department of Physical Therapy, Youngstown State University, Youngstown, OH, USA
    J Neurol 257:982-91. 2010

Detail Information

Publications324 found, 100 shown here

  1. ncbi Carotid artery stenosis: gray-scale and Doppler US diagnosis--Society of Radiologists in Ultrasound Consensus Conference
    Edward G Grant
    Department of Radiology, University of Southern California, Keck School of Medicine, USC University Hospital, 1500 San Pablo St, Los Angeles, CA 90033, USA
    Radiology 229:340-6. 2003
    ..The panel also considered various technical aspects of carotid US and methods for quality assessment and identified several important unanswered questions meriting future research...
  2. pmc Stenting versus endarterectomy for treatment of carotid-artery stenosis
    Thomas G Brott
    Mayo Clinic, Griffin 304, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    N Engl J Med 363:11-23. 2010
    ..Carotid-artery stenting and carotid endarterectomy are both options for treating carotid-artery stenosis, an important cause of stroke...
  3. ncbi Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion
    H Markus
    Clinical Neuroscience, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Brain 124:457-67. 2001
    ..studies suggest that impaired cerebral haemodynamics is associated with symptomatic status in patients with carotid stenosis and occlusion, but there is relatively little prospective data confirming this association...
  4. ncbi In vivo MRI-based 3D mechanical stress-strain profiles of carotid plaques with juxtaluminal plaque haemorrhage: an exploratory study for the mechanism of subsequent cerebrovascular events
    Z Teng
    University Department of Radiology, University of Cambridge, Level 5, Box 218, Addenbrooke s Hospital, Hills Rd, Cambridge CB2 0QQ, UK
    Eur J Vasc Endovasc Surg 42:427-33. 2011
    ..Three-dimensional mechanical analysis was employed to represent the critical mechanical stress (P-CStress) and stretch (P-CStretch) within the plaque...
  5. pmc Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
    Jörg Ederle
    Institute of Neurology, University College London, Box 6, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Lancet 375:985-97. 2010
    Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy...
  6. ncbi Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis
    P M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet 361:107-16. 2003
    Endarterectomy reduces risk of stroke in certain patients with recently symptomatic internal carotid stenosis. However, investigators have made different recommendations about the degree of stenosis above which surgery is effective, ..
  7. ncbi Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study
    Willem E Hellings
    Department of Vascular Surgery, Experimental Cardiology Laboratory, University Medical Center Utrecht, Heidelberglaan 100, Suite G02 523, 3584CX Utrecht, The Netherlands
    Circulation 121:1941-50. 2010
    ..The objective of the present study was to investigate whether atherosclerotic plaque composition is associated with the occurrence of future vascular events...
  8. ncbi Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men
    Navneet Singh
    Department of Diagnostic Imaging, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview St, Toronto, ON, Canada M4N 3M5
    Radiology 252:502-8. 2009
    ..IPH) in the carotid artery wall and the risk of future ipsilateral cerebrovascular events in men with asymptomatic moderate carotid stenosis by using a rapid three-dimensional T1-weighted fat-suppressed spoiled gradient-echo sequence.
  9. ncbi Cerebral hemodynamics and cognitive performance in bilateral asymptomatic carotid stenosis
    Clotilde Balucani
    Department of Neurology, University of Perugia, Perugia, Italy
    Neurology 79:1788-95. 2012
    To evaluate cognitive performance in subjects with bilateral asymptomatic carotid stenosis (B-ACS) compared to subjects with unilateral ACS and to subjects with no carotid stenosis (CS) and to explore the relationship between cognitive ..
  10. ncbi Cognitive and physical performance in patients with asymptomatic carotid artery disease
    Nancy C Landgraff
    Department of Physical Therapy, Youngstown State University, Youngstown, OH, USA
    J Neurol 257:982-91. 2010
    ..These areas of function and the potential change in their status need to be considered when patients are being evaluated for interventions to manage their carotid artery disease...
  11. ncbi Cerebrovascular reactivity to acetazolamide and outcome in patients with symptomatic internal carotid or middle cerebral artery occlusion: a xenon-133 single-photon emission computed tomography study
    Kuniaki Ogasawara
    Department of Neurosurgery and Cyclotron Research Center, Iwate Medical University, Morioka, Japan
    Stroke 33:1857-62. 2002
    ....
  12. ncbi Impaired cerebral vasoreactivity and risk of stroke in patients with asymptomatic carotid artery stenosis
    M Silvestrini
    Clinica Neurologica, Universita di Roma Tor Vergata, Ospedale S Eugenio, Rome, Italy
    JAMA 283:2122-7. 2000
    ..However, preliminary evidence suggests that an alteration in cerebral hemodynamic function may play a relevant role in the occurrence of stroke in patients with carotid artery disease...
  13. ncbi Histological assessment of 526 symptomatic carotid plaques in relation to the nature and timing of ischemic symptoms: the Oxford plaque study
    J N E Redgrave
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, OX2 6HE, United Kingdom
    Circulation 113:2320-8. 2006
    ..Previous histological studies have been too small or insufficiently detailed to reliably determine the temporal course of features of plaque instability or to stratify analyses by the nature of presenting symptoms...
  14. ncbi Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events--a longitudinal in vivo magnetic resonance imaging-based finite element study
    U Sadat
    University Department of Radiology, University of Cambridge, Cambridge, UK
    Eur J Vasc Endovasc Surg 40:485-91. 2010
    ..The biomechanical stress profile of stable plaques has been observed to differ from that of unstable plaques; however, the role that structural stresses play in determining plaque vulnerability remains speculative...
  15. ncbi Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events
    Nishath Altaf
    Department of Vascular and Endovascular Surgery, Queen s Medical Centre, Nottingham, United Kingdom
    J Vasc Surg 47:337-42. 2008
    Carotid endarterectomy is beneficial in severe (>70%) symptomatic carotid stenosis. The risk of stroke in moderate carotid stenosis (50%-69%) is modest, and so the role of carotid endarterectomy in this group is unclear...
  16. ncbi Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, WA, USA
    Stroke 37:818-23. 2006
    ..We tested the hypothesis that the characteristics of carotid plaque, as assessed by MRI, are possible predictors of future ipsilateral cerebrovascular events...
  17. ncbi Neuropsychological impairment in stroke, carotid stenosis, and peripheral vascular disease, A comparison with healthy community residents
    R Rao
    Department of Old Age Psychiatry, Maudsley Hospital, Institute of Psychiatry, King s College School of Medicine and Dentistry, Dulwich Hospital, London, UK
    Stroke 30:2167-73. 1999
    ..The main hypothesis was that older people with both transient ischemic attack (TIA) and PVD would demonstrate greater cognitive impairment than controls...
  18. pmc Cerebrovascular reserve and stroke risk in patients with carotid stenosis or occlusion: a systematic review and meta-analysis
    Ajay Gupta
    Department of Radiology, Weill Cornell Medical School, New York Presbyterian Hospital, 525 East 68th Street, Starr 8A, Box 141, New York, NY 10065, USA
    Stroke 43:2884-91. 2012
    ..The purpose of this study is to perform a systematic review and meta-analysis to summarize the association of CVR impairment and stroke risk...
  19. ncbi Impairments in cognitive function and brain connectivity in severe asymptomatic carotid stenosis
    Hsien Lin Cheng
    Institute of Brain Science, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Stroke 43:2567-73. 2012
    Severe asymptomatic carotid stenosis has been associated with cognitive impairment, but it is unknown whether this association is attributable to effects on brain connectivity...
  20. ncbi Management strategies for asymptomatic carotid stenosis: a systematic review and meta-analysis
    Gowri Raman
    Center for Clinical Evidence Synthesis and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 158:676-85. 2013
    ..Adults with asymptomatic carotid artery stenosis are at increased risk for ipsilateral carotid territory ischemic stroke...
  21. pmc Identification of intraplaque hemorrhage on MR angiography images: a comparison of contrast-enhanced mask and time-of-flight techniques
    Y Qiao
    The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    AJNR Am J Neuroradiol 32:454-9. 2011
    ..We sought to determine the accuracy and reliability of these MRA sequences to detect IPH...
  22. ncbi Atherosclerotic plaque rupture and intraplaque hemorrhage do not correlate with symptoms in carotid artery stenosis
    Jose Milei
    Instituto de Investigaciones Cardiologicas, Marcelo T de Alvear 2270, C1122AAJ, Buenos Aires, Argentina
    J Vasc Surg 38:1241-7. 2003
    ..The purpose of this study was to analyze the relation between the anatomy of the carotid plaques and the presence of symptoms in 281 carotid endarterectomy specimens...
  23. ncbi Improved carotid atherosclerotic plaques imaging with contrast-enhanced ultrasound (CEUS)
    D A Clevert
    Department of Clinical Radiology, Klinikum Grosshadern, University of Munich, Munich, Germany
    Clin Hemorheol Microcirc 48:141-8. 2011
    ..To evaluate neovascularisation within carotid atherosclerotic plaques with contrast enhanced ultrasound...
  24. ncbi Study of reproducibility of human arterial plaque reconstruction and its effects on stress analysis based on multispectral in vivo magnetic resonance imaging
    Hao Gao
    Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex, UK
    J Magn Reson Imaging 30:85-93. 2009
    ..To quantify the uncertainties of carotid plaque morphology reconstruction based on patient-specific multispectral in vivo magnetic resonance imaging (MRI) and their impacts on the plaque stress analysis...
  25. ncbi Four-dimensional ultrasonographic characterization of plaque surface motion in patients with symptomatic and asymptomatic carotid artery stenosis
    S Meairs
    Department of Neurology, University of Heidelberg, Klinikum Mannheim, Mannheim, Germany
    Stroke 30:1807-13. 1999
    ..We investigated plaque surface deformations in patients with symptomatic and asymptomatic carotid artery disease using 4-dimensional ultrasonography and techniques for measuring optical flow...
  26. ncbi An enriched environment reverses the synaptic plasticity deficit induced by chronic cerebral hypoperfusion
    Hong Zhu
    Department of Neurology, Zhongnan Hospital, Wuhan University, No 169 Donghu Road, Wuchang District, Wuhan 430071, China
    Neurosci Lett 502:71-5. 2011
    ..The EE effect probably resulted from the regulation of postsynaptic potentiation...
  27. ncbi Carotid stenosis and the cognitive function
    Laszlo K Sztriha
    Department of Neurology, Albert Szent Gyorgyi Clinical Center, University of Szeged, Szeged, Hungary
    J Neurol Sci 283:36-40. 2009
    ..The evidence available at present does not seem strong enough to include consideration of a loss of cognition as a factor in determining the balance of the risks and benefits of therapy for a carotid stenosis.
  28. ncbi Short-term outcome after stenting versus endarterectomy for symptomatic carotid stenosis: a preplanned meta-analysis of individual patient data
    Leo H Bonati
    Department of Neurology and StrokeUnit, University Hospital Basel, Switzerland
    Lancet 376:1062-73. 2010
    ..of stroke associated with carotid stenting than with carotid endarterectomy for the treatment of symptomatic carotid stenosis. However, these trials were underpowered for investigation of whether carotid artery stenting might be a safe ..
  29. ncbi Relationships between recent intraplaque hemorrhage and stroke risk factors in patients with carotid stenosis: the HIRISC study
    Guillaume Turc
    Department of Neurology Hôpital Sainte Anne, 1 rue Cabanis, 75014 Paris, France
    Arterioscler Thromb Vasc Biol 32:492-9. 2012
    ..However, little is known about the relationships between IPH and traditional risk factors and whether these relationships differ between symptomatic and asymptomatic disease...
  30. ncbi Comparison of the five 2011 guidelines for the treatment of carotid stenosis
    Kosmas I Paraskevas
    Department of Vascular and Endovascular Surgery, Klinikum Nürnberg Süd, Nurnberg, Germany
    J Vasc Surg 55:1504-8. 2012
    ..The differences in the recommendations between the five Guideline Committees are analyzed and discussed...
  31. pmc Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study
    William S Kerwin
    Department of Radiology, Division of Cardiology, and Department of Surgery, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
    Radiology 241:459-68. 2006
    ..To prospectively evaluate if there is an association between plaque enhancement at magnetic resonance (MR) imaging and proinflammatory cardiovascular risk factors and plaque content...
  32. ncbi MR carotid plaque imaging and contrast-enhanced MR angiography identifies lesions associated with recent ipsilateral thromboembolic symptoms: an in vivo study at 3T
    J K Demarco
    Department of Radiology, Michigan State University, East Lansing, MI, USA
    AJNR Am J Neuroradiol 31:1395-402. 2010
    ..This study aims to identify specific plaque features on 3T carotid MR imaging and CE-MRA associated with recent carotid thromboembolic symptoms in patients with mild/moderate versus severe stenosis...
  33. ncbi New brain lesions after carotid revascularization are not associated with cognitive performance
    Katrin Wasser
    Department of Neurology, University of Gottingen, Gottingen, Germany
    J Vasc Surg 53:61-70. 2011
    ..is increasingly being used as a treatment alternative to endarterectomy (CEA) for patients with significant carotid stenosis. However, diffusion-weighted imaging (DWI) has indicated that CAS is associated with a significantly higher ..
  34. ncbi Evidence-based treatment of carotid artery stenosis
    Kate C Young
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14620, USA
    Neurosurg Focus 30:E2. 2011
    ..Finally, the choice of revascularization technique is discussed with respect to symptom status. Based on current evidence, CAS should remain limited to specific indications...
  35. ncbi Carotid artery stenting in acute stroke
    Panagiotis Papanagiotou
    Clinic for Diagnostic and Interventional Neuroradiology, Saarland University Hospital, Homburg, Germany
    J Am Coll Cardiol 58:2363-9. 2011
    ..The purpose of this study is to demonstrate the technical success of carotid artery stenting in acute extracranial internal carotid artery (ICA) occlusion as well as the benefit in clinical outcome...
  36. pmc Preliminary in vivo atherosclerotic carotid plaque characterization using the accumulated axial strain and relative lateral shift strain indices
    Hairong Shi
    Department of Medical Physics, The University of Wisconsin Madison, Madison, WI 53706, USA
    Phys Med Biol 53:6377-94. 2008
    ....
  37. ncbi Functional profile of activated dendritic cells in unstable atherosclerotic plaque
    Christian Erbel
    Department of Cardiology, Internal Medical Clinic III University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    Basic Res Cardiol 102:123-32. 2007
    ..This study established a functional profile of plaque-residing dendritic cells (DC) to examine whether they can function as Ag-presenting cells to facilitate in situ T-cell activation...
  38. ncbi Study of carotid arterial plaque stress for symptomatic and asymptomatic patients
    Hao Gao
    Centre for excellence in Signal and Image Processing, Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow G11XW, UK
    J Biomech 44:2551-7. 2011
    ..The combined analyses of plaque MR image and plaque stress will advance our understanding of plaque rupture, and provide a useful tool on assessing plaque rupture risk...
  39. ncbi Discriminating carotid atherosclerotic lesion severity by luminal stenosis and plaque burden: a comparison utilizing high-resolution magnetic resonance imaging at 3.0 Tesla
    Xihai Zhao
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Stroke 42:347-53. 2011
    ..To determine associations between stenosis, measures of plaque burden, and compositional features of carotid atherosclerosis, including high-risk features of intraplaque hemorrhage (IPH) and surface disruption...
  40. ncbi Identification of carotid 'vulnerable plaque' by contrast-enhanced ultrasonography: correlation with plaque histology, symptoms and cerebral computed tomography
    G L Faggioli
    Department of Specialistic Surgeries and Anesthesiological Sciences, University of Bologna, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    Eur J Vasc Endovasc Surg 41:238-48. 2011
    ..We investigated the role of contrast-enhanced ultrasonography (CEUS) to identify carotid vulnerable plaque...
  41. ncbi Vasa vasorum and plaque neovascularization on contrast-enhanced carotid ultrasound imaging correlates with cardiovascular disease and past cardiovascular events
    Daniel Staub
    Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Stroke 41:41-7. 2010
    ..In this observational study, the presence of carotid intraplaque neovascularization and adventitial vasa vasorum were correlated with the presence and occurrence of cardiovascular disease (CVD) and events (CVE)...
  42. ncbi Carotid artery stents: in vitro comparison of different stent designs and sizes using CT angiography and contrast-enhanced MR angiography at 1.5T and 3T
    M Lettau
    Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany
    AJNR Am J Neuroradiol 30:1993-7. 2009
    ..5T, and CE-MRA at 3T for the visualization of carotid artery stents and to define the best noninvasive imaging technique as an alternative to conventional angiography for each stent...
  43. ncbi Risk of stroke, transient ischemic attack, and vessel occlusion before endarterectomy in patients with symptomatic severe carotid stenosis
    Till Blaser
    Department of Neurology, University of Magdeburg, Magdeburg, Germany
    Stroke 33:1057-62. 2002
    ..We aimed to identify and determine the clinical relevance of parameters predictive of stroke recurrence and vessel occlusion before carotid endarterectomy...
  44. ncbi Outcome of carotid artery occlusion is predicted by cerebrovascular reactivity
    F Vernieri
    AFaR CRCCS Divisione di Neurologia Ospedale Fatebenefratelli, Isola Tiberina, Roma, Italy
    Stroke 30:593-8. 1999
    ....
  45. ncbi Duplex ultrasound and magnetic resonance angiography compared with digital subtraction angiography in carotid artery stenosis: a systematic review
    Paul J Nederkoorn
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 34:1324-32. 2003
    ....
  46. ncbi Long-term prognosis of medically treated patients with internal carotid or middle cerebral artery occlusion: can acetazolamide test predict it?
    S Kuroda
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Hokkaido Neurosurgical Memorial Hospital, Sapporo, Japan
    Stroke 32:2110-6. 2001
    ....
  47. ncbi Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial
    Ka Sing Lawrence Wong
    Departments of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    Lancet Neurol 9:489-97. 2010
    ..marker of future stroke risk and have been used to show treatment efficacy in patients with extracranial carotid stenosis. We aimed to investigate whether treatment with clopidogrel plus aspirin reduced the number of microembolic ..
  48. ncbi Differences between carotid wall morphological phenotypes measured by ultrasound in one, two and three dimensions
    Khalid Al-Shali
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, 406 100 Perth Drive, London, Ont, Canada N6A 5K8
    Atherosclerosis 178:319-25. 2005
    ..Because the measurements have different implications and determinants, investigators might need to be selective about the particular measurements they choose for specific applications...
  49. ncbi Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis
    Nishath Altaf
    Department of Academic Radiology, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Stroke 38:1633-5. 2007
    ..The aim of this study was to assess whether the identification of IPH by MRI predicts recurrent clinical cerebrovascular events...
  50. pmc Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: an in vivo MRI-based 3D fluid-structure interaction study
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Stroke 40:3258-63. 2009
    ..To test that hypothesis, 3D fluid-structure interaction models were constructed based on in vivo MRI data of human atherosclerotic carotid plaques to assess structural stress behaviors of plaques with and without rupture...
  51. ncbi Clinical imaging of the high-risk or vulnerable atherosclerotic plaque
    Z A Fayad
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circ Res 89:305-16. 2001
    ....
  52. ncbi In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI
    Rikin A Trivedi
    University Department of Radiology, Addenbrooke s Hospital, Cambridge, UK
    Stroke 35:1631-5. 2004
    ..The purpose of this study was to determine the time course for macrophage visualization with in vivo contrast-enhanced MRI using an ultrasmall superparamagnetic iron oxide (USPIO) agent in symptomatic human carotid disease...
  53. ncbi MR imaging of adventitial vasa vasorum in carotid atherosclerosis
    W S Kerwin
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Magn Reson Med 59:507-14. 2008
    ..141 +/- 0.036 vs. 0.111 +/- 0.017 min(-1); P = 0.02). Because these factors are all associated with higher risk of atherosclerotic complications, these results suggest that adventitial K(trans) may be a marker of risk as well...
  54. ncbi Medical (nonsurgical) intervention alone is now best for prevention of stroke associated with asymptomatic severe carotid stenosis: results of a systematic review and analysis
    Anne L Abbott
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Stroke 40:e573-83. 2009
    ..advances in vascular disease medical intervention since large randomized trials for asymptomatic severe carotid stenosis were conducted (1983-2003) have prompted doubt over current expectations of a surgical benefit...
  55. ncbi Relationship between blood pressure and stroke risk in patients with symptomatic carotid occlusive disease
    P M Rothwell
    Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Rd, Oxford OX2 6HE UK
    Stroke 34:2583-90. 2003
    ..with severe carotid occlusive disease, particularly those with a carotid occlusion or bilateral > or =70% carotid stenosis in whom cerebral perfusion is often impaired and may depend directly on systemic blood pressure...
  56. ncbi Joint recommendations for reporting carotid ultrasound investigations in the United Kingdom
    C P Oates
    Regional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne NE4 6BE, United Kingdom
    Eur J Vasc Endovasc Surg 37:251-61. 2009
    ..General recommendations are also given for the acquisition, interpretation and reporting of the data...
  57. ncbi Carotid stenosis after adjuvant cervical radiotherapy in patients with head and neck cancers: a prospective controlled study
    A Greco
    Department of Sensory Organs, Otorhinolaryngology Section Sapienza University of Rome, Rome, Italy
    Clin Otolaryngol 37:376-81. 2012
    To determine the prevalence of radiation-induced carotid stenosis, in patients who were treated for head and neck malignancies, using colour-flow duplex scanning.
  58. ncbi Intensity of chronic cerebral hypoperfusion determines white/gray matter injury and cognitive/motor dysfunction in mice
    Kazunori Miki
    Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurosci Res 87:1270-81. 2009
    ..Our MCH mouse model with the development of several types of neurological dysfunction with high reproducibility would be useful for investigating the pathomechanisms of WM injury in human SIVD...
  59. ncbi Vaspin serum concentrations in patients with carotid stenosis
    Gabriela Aust
    Center of Surgery, Department of Visceral, Transplantation, Thoracic, and Vascular Surgery, Medical Faculty, University of Leipzig, Leipzig, Germany
    Atherosclerosis 204:262-6. 2009
    ..We therefore assessed vaspin serum concentrations in 107 consecutive patients with carotid stenosis undergoing carotid endarterectomy (CEA) in relation to severity of atherosclerosis, measures of obesity and ..
  60. ncbi Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up study by magnetic resonance imaging
    Robert M Kwee
    Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands
    Invest Radiol 45:803-9. 2010
    ..To investigate the natural course of carotid plaque progression in transient ischemic attack/stroke patients by using serial multisequence magnetic resonance imaging (MRI)...
  61. ncbi Histological features of symptomatic carotid plaques in relation to age and smoking: the oxford plaque study
    Jessica N E Redgrave
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Stroke 41:2288-94. 2010
    ..However, in patients with similarly severe symptomatic carotid stenosis, increasing age is associated with a greater risk of ipsilateral ischemic stroke...
  62. ncbi Automated in vivo segmentation of carotid plaque MRI with Morphology-Enhanced probability maps
    Fei Liu
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Magn Reson Med 55:659-68. 2006
    ..71, 0.76, 0.33, and 0.78, respectively. These results show that in vivo automatic segmentation of carotid MRI is feasible and comparable to or possibly more accurate than manual review for quantifying plaque composition...
  63. ncbi Cerebrovascular reactivity within perfusion territories in patients with an internal carotid artery occlusion
    Reinoud P H Bokkers
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 82:1011-6. 2011
    ....
  64. ncbi Neurological complications of carotid revascularisation
    Teddy Y Wu
    Department of Neurology, Auckland City Hospital, Auckland, New Zealand
    J Neurol Neurosurg Psychiatry 83:543-50. 2012
    Carotid endarterectomy (CEA) is an effective treatment for patients with recently symptomatic severe carotid stenosis and in selected patients with symptomatic moderate carotid stenosis...
  65. ncbi The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study. Evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease
    Tjun Y Tang
    University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    J Am Coll Cardiol 53:2039-50. 2009
    ..The hypothesis was that treatment with 80 mg atorvastatin would demonstrate quantifiable changes in USPIO-enhanced MRI-defined inflammation within the first 3 months of therapy...
  66. ncbi Utility of high resolution MR imaging to assess carotid plaque morphology: a comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease
    Umar Sadat
    University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Atherosclerosis 207:434-9. 2009
    ....
  67. ncbi Numerical simulation of blood pulsatile flow in a stenosed carotid artery using different rheological models
    A Razavi
    Department of Mechanical Engineering, Isfahan University of Technology, Isfahan 8415683111, Iran
    J Biomech 44:2021-30. 2011
    ..Increasing stenosis intensity causes flow patterns more disturbed downstream of the stenosis and WSS appear to develop remarkably at the stenosis throat...
  68. ncbi Complex neurodegeneration in retina following moderate ischemia induced by bilateral common carotid artery occlusion in Wistar rats
    Hideo Yamamoto
    Bascom Palmer Eye Institute, Ophthalmic Biophysics Center, University of Miami School of Medicine, P O Box 016880, Miami, FL 33101, USA
    Exp Eye Res 82:767-79. 2006
    ..In conclusion, chronic BCCAO produced delayed neuronal death in the retina of adult male Wistar rats. The window of moderate changes of at least 1 day may facilitate molecular studies on retinal ganglion cell loss...
  69. ncbi Severity of asymptomatic carotid stenosis and risk of ipsilateral hemispheric ischaemic events: results from the ACSRS study
    A N Nicolaides
    Department of Vascular Surgery, Imperial College, London, UK
    Eur J Vasc Endovasc Surg 30:275-84. 2005
    This study determines the risk of ipsilateral ischaemic neurological events in relation to the degree of asymptomatic carotid stenosis and other risk factors.
  70. ncbi Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity
    Stefano Coli
    Department of Cardiothoracic and Vascular Diseases, University Vita Salute, San Raffaele Scientific Institute, Milan, Italy
    J Am Coll Cardiol 52:223-30. 2008
    ..This study was designed to evaluate contrast-enhanced ultrasound imaging of carotid atherosclerosis as a clinical tool to study intraplaque neovascularization...
  71. ncbi In vivo 3D high-spatial-resolution MR imaging of intraplaque hemorrhage
    Richard Bitar
    Department of Medical Imaging, University of Toronto, Toronto, Canada
    Radiology 249:259-67. 2008
    ....
  72. ncbi Critical appraisal of the Carotid Duplex Consensus criteria in the diagnosis of carotid artery stenosis
    Ali F Aburahma
    Department of Surgery, Robert C Byrd Health Sciences Center, West Virginia University, Charleston, WV, USA
    J Vasc Surg 53:53-9; discussion 59-60. 2011
    ..Clinicians have relied on published institutional experience for interpreting carotid duplex ultrasound studies (CDUS). This study will validate the ultrasound imaging consensus criteria published in 2003...
  73. ncbi New ischaemic brain lesions on MRI after stenting or endarterectomy for symptomatic carotid stenosis: a substudy of the International Carotid Stenting Study (ICSS)
    Leo H Bonati
    Department of Neurology and Stroke Unit, University Hospital Basel, Basel, Switzerland
    Lancet Neurol 9:353-62. 2010
    The International Carotid Stenting Study (ICSS) of stenting and endarterectomy for symptomatic carotid stenosis found a higher incidence of stroke within 30 days of stenting compared with endarterectomy...
  74. ncbi Non-uniform shrinkage for obtaining computational start shape for in-vivo MRI-based plaque vulnerability assessment
    Yuan Huang
    University Department of Radiology, University of Cambridge, Cambridge, UK
    J Biomech 44:2316-9. 2011
    ..However, in order to make accurate predictions, the computational model must be based on the loading-free geometry. A shrinkage procedure can be used to obtain the computational start shape...
  75. ncbi Role of conventional angiography in evaluation of patients with carotid artery stenosis demonstrated by Doppler ultrasound in general practice
    A I Qureshi
    Department of Neurosurgery and Toshiba Stroke Research Center, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, USA
    Stroke 32:2287-91. 2001
    Previous studies have suggested that patients with carotid stenosis who are candidates for endarterectomy can be effectively identified on the basis of carotid Doppler ultrasound alone...
  76. ncbi High-intensity signal on time-of-flight magnetic resonance angiography indicates carotid plaques at high risk for cerebral embolism during stenting
    Shinichi Yoshimura
    Department of Neurosurgery, Graduate School of Medicine, Gifu University, Yanagido, Gifu City, Gifu 501 1194, Japan
    Stroke 42:3132-7. 2011
    ..The present study examined whether high-intensity signal (HIS) in the plaque on time-of-flight (TOF) MRA, performed for screening, can discriminate plaque at high risk for cerebral embolism during CAS...
  77. ncbi Carotid stenting improves cognitive function in asymptomatic cerebral ischemia
    Ying Hsien Chen
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Int J Cardiol 157:104-7. 2012
    ..Asymptomatic critical internal carotid artery (ICA) stenosis may lead to cognitive impairment. Carotid stenting (CS) may improve cerebral perfusion, but its impact on neuro-cognitive function has been controversial...
  78. ncbi Cerebral hemodynamics and cognitive performance in patients with asymptomatic carotid stenosis
    M Silvestrini
    Department of Neuroscience, Marche Polytechnic University, Via Conca 1, 60020 Ancona, Italy
    Neurology 72:1062-8. 2009
    ..The aim of this study was to investigate whether the presence of severe internal carotid artery stenosis may be associated with different cognitive performance in relation to the side of the stenosis and its hemodynamic consequences...
  79. ncbi Clinical considerations in the management of asymptomatic carotid artery stenosis
    Philipp Taussky
    Department of Neurosurgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Neurosurg Focus 31:E7. 2011
    ..The following review summarizes current knowledge of the natural history, diagnosis, and treatment strategies to counsel patients with asymptomatic carotid artery stenosis...
  80. pmc Carotid plaque neovascularization and hemorrhage detected by MR imaging are associated with recent cerebrovascular ischemic events
    Y Qiao
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    AJNR Am J Neuroradiol 33:755-60. 2012
    ..Our aim was to determine the associations of these features in carotid plaques with previous cerebrovascular ischemic events by using high-resolution CE-MRI...
  81. ncbi Carotid artery stenting versus carotid endarterectomy: a comprehensive meta-analysis of short-term and long-term outcomes
    Konstantinos P Economopoulos
    School of Medicine, University of Athens, 5 Menalou, Maroussi, Athens, Greece
    Stroke 42:687-92. 2011
    ..The comparison between carotid endarterectomy and carotid artery stenting (CAS) remains a debated field, especially in the context of long-term outcomes...
  82. ncbi Quantitative segmentation of principal carotid atherosclerotic lesion components by feature space analysis based on multicontrast MRI at 1.5 T
    Christof Karmonik
    Department of Radiology, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    IEEE Trans Biomed Eng 56:352-60. 2009
    ..Combination of mc-MRI and FSA may have an application for determining atherosclerotic lesion composition and monitoring treatment in vivo...
  83. ncbi Prevalence of complicated carotid atheroma as detected by magnetic resonance direct thrombus imaging in patients with suspected carotid artery stenosis and previous acute cerebral ischemia
    Rachael E Murphy
    Department of Academic Radiology, University Hospital, Nottingham, UK
    Circulation 107:3053-8. 2003
    ....
  84. ncbi Carotid plaque compared with intima-media thickness as a predictor of coronary and cerebrovascular disease
    Stein Harald Johnsen
    Department of Neurology, University Hospital North Norway, N 9038 Breivika, Tromsø, Norway
    Curr Cardiol Rep 11:21-7. 2009
    ..Echolucent plaque morphology (ie, lipid-rich plaques) seems to increase the risk for MI and stroke. New evidence suggests that total plaque area is the most strongly predictive of cardiovascular risk of the ultrasound phenotypes...
  85. ncbi Impact of plaque haemorrhage and its age on structural stresses in atherosclerotic plaques of patients with carotid artery disease: an MR imaging-based finite element simulation study
    Umar Sadat
    University Department of Radiology, University of Cambridge, Addenbrooke s Hospital, Box 218, Level 5, Hills Road, Cambridge CB2 0QQ, UK
    Int J Cardiovasc Imaging 27:397-402. 2011
    ..Plaque component-dependent stress analysis has the potential of identifying the critical nature of various plaque components...
  86. pmc Erythrocyte aggregation as an early biomarker in patients with asymptomatic carotid stenosis
    Einor Ben Assayag
    Department of Neurology, Tel Aviv Sourasky Medical Center affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Dis Markers 24:33-9. 2008
    ..Atherosclerosis is a chronic inflammatory disease...
  87. ncbi Relief of carotid stenosis improves impaired cognition in a rat model of chronic cerebral hypoperfusion
    Wei Duan
    Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China
    Acta Neurobiol Exp (Wars) 71:233-43. 2011
    To investigate how cognitive impairment is affected by the relief of bilateral carotid stenosis, chronic cerebral hypoperfusion was established through stenosis of the bilateral carotid common artery in adult Sprague-Dawley rats...
  88. ncbi Cognitive functions of carotid artery stenosis in the aged rat
    Z Zhou
    Department of Neurology, Southwest Hospital, Third Military Medical University, Shapingba, Chongqing 400038, PR China
    Neuroscience 219:137-44. 2012
    ..But the mechanisms of cognitive impairments occurring in patients with asymptomatic carotid stenosis are poorly understood. One important reason is the absence of a good carotid stenosis model...
  89. ncbi High signal intensity halo around the carotid artery on maximum intensity projection images of time-of-flight MR angiography: a new sign for intraplaque hemorrhage
    Yoo Jeong Yim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Magn Reson Imaging 27:1341-6. 2008
    ..To evaluate the value of the high signal intensity halo sign as a new marker of a fresh or recent intraplaque hemorrhage on the maximum intensity projection (MIP) images of time-of-flight (TOF) MR angiography...
  90. ncbi Carotid stenosis degree in CT angiography: assessment based on luminal area versus luminal diameter measurements
    Zishu Zhang
    Department of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland
    Eur Radiol 15:2359-65. 2005
    ..Area stenosis provides a less-severe estimate of the degree of carotid stenosis but might theoretically express the real hemodynamic significance of the lesion better than diameter stenosis,..
  91. ncbi Prediction and prevention of stroke in patients with symptomatic carotid stenosis: the high-risk period and the high-risk patient
    P M Rothwell
    University Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Eur J Vasc Endovasc Surg 35:255-63. 2008
    ..have shown that surgery reduces the risk of stroke in patients with > or =50% recently symptomatic carotid stenosis, but more recent research has shown that the effectiveness of surgery is highly dependent on timing and on ..
  92. ncbi Clinical and angiographic risk factors for stroke and death within 30 days after carotid endarterectomy and stent-protected angioplasty: a subanalysis of the SPACE study
    Robert Stingele
    Department of Neurology, University Hospital Schleswig Holstein, Kiel, Germany
    Lancet Neurol 7:216-22. 2008
    ..Better knowledge of risk factors could improve assignment of patients to these procedures and reduce overall risk. We aimed to assess the risk of stroke or death associated with CEA and CAS in patients with different risk factors...
  93. ncbi Vasodilatory capacity of the cerebral vasculature in patients with carotid artery stenosis
    R P H Bokkers
    Department of Radiology, University Medical Center Utrecht, The Netherlands
    AJNR Am J Neuroradiol 32:1030-3. 2011
    ..The aim of our study was to investigate the vasodilatory capacity of the proximal and distal cerebral vasculature in patients with an ICA stenosis and healthy control subjects by combining MRA with an acetazolamide provocation challenge...
  94. ncbi Medical and surgical management of symptomatic carotid stenosis
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Int J Stroke 1:140-9. 2006
    ..have shown that surgery reduces the risk of stroke in patients with > or = 50% recently symptomatic carotid stenosis, and more recent research has gone some way to wards identifying which patients benefit the most...
  95. ncbi Clinical validation of an automated vessel-segmentation software of the extracranial-carotid arteries based on 3D-MRA: a prospective study
    R Guzman
    Department of Neurosurgery, Inselspital, Bern, Switzerland
    J Neuroradiol 35:278-85. 2008
    ..To determine the accuracy of automated vessel-segmentation software for vessel-diameter measurements based on three-dimensional contrast-enhanced magnetic resonance angiography (3D-MRA)...
  96. ncbi Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization
    Steven B Feinstein
    Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Am Coll Cardiol 48:236-43. 2006
    ..With continued clinical investigation, CU imaging of the carotid artery may afford an effective means to non-invasively identify atherosclerosis in "at-risk" populations while providing new standard for therapeutic monitoring...
  97. ncbi Geometric and compositional appearance of atheroma in an angiographically normal carotid artery in patients with atherosclerosis
    L Dong
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    AJNR Am J Neuroradiol 31:311-6. 2010
    ..Arterial remodeling may enable atherosclerotic disease without luminal stenosis. We sought to assess the prevalence and characteristics of atherosclerosis in angiographically normal carotid arteries...
  98. ncbi How critical is fibrous cap thickness to carotid plaque stability? A flow-plaque interaction model
    Zhi Yong Li
    Department of Radiology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Stroke 37:1195-9. 2006
    ..We used a flow-structure interaction model to simulate the interaction between blood flow and atheromatous plaque to evaluate the effect of the degree of luminal stenosis and fibrous cap thickness on plaque vulnerability...
  99. ncbi Early carotid endarterectomy after intravenous thrombolysis for acute ischaemic stroke
    M A Bartoli
    Faculte de Medecine de Marseille, Universite de la Mediterranee, Assistance Publique Hopitaux de Marseille, Hopital de la Timone, Service de Chirurgie Vasculaire, 13005 Marseille, France
    Eur J Vasc Endovasc Surg 37:512-8. 2009
    ..However, it is not well known whether CEA can be performed safely after thrombolysis, and, if so, when. We report a prospective study of CEA for residual high-grade cervical ICA stenosis performed within 15 days after IVT for AIS...
  100. ncbi Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the 'Efficacy of Nitric Oxide in Stroke' trial
    Gillian M Sare
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Blood Press Monit 14:20-5. 2009
    ..Particular uncertainty exists in patients with carotid stenosis in whom lowering BP might reduce cerebral perfusion and worsen outcome.
  101. ncbi Embolic complications after carotid artery stenting or carotid endarterectomy are associated with tissue characteristics of carotid plaques evaluated by magnetic resonance imaging
    Kiyofumi Yamada
    Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
    Atherosclerosis 215:399-404. 2011
    ..The aim of this study was to elucidate the relationship between the tissue components of carotid plaques and the incidence of new ipsilateral silent ischemic lesions (NISIL) after CAS or CEA...

Research Grants62

  1. CEREBROVASCULAR RESERVE BY XE/CT VERSUS TCD AND OXIMETRY
    Ronda Pindzola; Fiscal Year: 2003
    ..Yonas and Nemoto on studies involving patients with SAH or carotid stenosis/occlusion...
  2. Iron and Atherosclerosis
    Subha V Raman; Fiscal Year: 2013
    ..This research tests the theory that monthly loss of iron through menses is protective against atherosclerosis, which could lead to an entirely new approach to preventing and treating heart and vascular disease in both men and women. ..
  3. APOPTOSIS OF SMOOTH MUSCLE CELLS IN CAROTID PLAQUES
    Devendra K Agrawal; Fiscal Year: 2013
    ..leading to increased inflammation and apoptosis of VSMCs in carotid plaques of symptomatic patients with carotid stenosis, and that atheroma-associated cytokines modulate NPY receptors and their function in VSMCs of carotid plaques...
  4. NOVEL FACTORS FOR UNEXPLAINED PHENOTYPES OF SUBCLINICAL CAROTID ATHEROSCLEROSIS
    Tatjana Rundek; Fiscal Year: 2013
    ....
  5. Comparative Effectiveness of Treatment Options for Asymptomatic Carotid Disease
    Steven D Pizer; Fiscal Year: 2013
    ..FY2009 performed by our study team revealed approximately 10,000 unique VA patients with diagnosis codes for carotid stenosis and 2,500 with procedure codes for CEA...
  6. Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates
    Brajesh K Lal; Fiscal Year: 2013
    ..Cognitive impairment is a more insidious but poorly understood outcome in patients with "asymptomatic" carotid stenosis who have not suffered a stroke...
  7. The Role of Monocytes in SLE-related Accelerated Atherosclerosis
    Brian J Skaggs; Fiscal Year: 2013
    ..UCLA is an ideal place for the principal investigator to transition into an independent academic career. ..
  8. SECONDARY PREVENTION OF SMALL SUBCORTICAL STROKES (SPS3)
    Oscar R Benavente; Fiscal Year: 2012
    ..enroll 3000 participants (20% of whom will be Hispanic Americans) with symptomatic, MRI-defined S3 without carotid stenosis or major cardio-embolic sources. Patients are assigned, in a factorial design, to two interventions: 1...
  9. Mechanism of Cognitive Dysfunction: CEA and Stenting
    ERIC JOHN HEYER; Fiscal Year: 2012
    ....
  10. Leveraging Health IT to Avoid Unnecessary Asymptomatic Carotid Revascularization
    Philip P Goodney; Fiscal Year: 2013
    ..When considering revascularization for asymptomatic carotid stenosis, patients and providers must weigh the up-front risk of surgery against the long-term risk of stroke, taken ..
  11. Comparative Effectiveness of Carotid Artery Revascularization vs Medical Therapy
    Salomeh Keyhani; Fiscal Year: 2013
    ..CEA) is superior to medical therapy in preventing stroke in both asymptomatic and symptomatic patients with carotid stenosis. However, while the majority of patients who undergo carotid revascularization receive treatment for ..
  12. PET/MRI of atherosclerosis
    Chun Yuan; Fiscal Year: 2012
    ..The goal of this proposal is to develop a quantitative, reliable, and comprehensive combined MRI PET approach for characterizing carotid artery plaque and inflammation. ..
  13. VISUAL FUNCTION IN RETINAL ISCHEMIA
    Mary Johnson; Fiscal Year: 1992
    ..characterized, both for its own predictive value and for what it may teach us about the effects of incipient carotid stenosis on retinal function...
  14. Cholesterol Homeostasis in Framingham Offspring Study
    Alice Lichtenstein; Fiscal Year: 2006
    ..in plasma samples from Framingham Offspring Study participants diagnosed with established CVD and/or >50% carotid stenosis (N=165) not taking lipid-lowering medication and control subjects matched for age, sex, body mass index, ..
  15. Point-of-Care Carotid Ultrasound and Cardiovascular Risk Assessment Device
    William F Weitzel; Fiscal Year: 2013
    ..system hardware architecture to: 1) extend data acquisition into 3D meeting the point-of-care needs for carotid stenosis assessment, 2) develop server side system algorithms for improved operator independent measurements of ..
  16. Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical Sequelae
    Chun Yuan; Fiscal Year: 2013
    ..Since IPH has been recognized at all levels of carotid stenosis, the identification of benefits, if any, from medical therapy is a critical gap in the current knowledge of ..
  17. Blood Flow and Cognition in Asymptomatic Carotid Artery Disease
    Randolph S Marshall; Fiscal Year: 2013
    ..compelling public-health impact, however, with 124,000 individuals over age 60 currently harboring high-grade carotid stenosis in the US alone...
  18. Carotid angioplasty and stenting in the elderly
    Brahmajee Nallamothu; Fiscal Year: 2009
    ..We anticipate that findings from this study will add new knowledge to both these areas and help inform policy-makers, payers, providers and patients struggling to determine the optimal role of CAS in preventing stroke and death. ..
  19. SPECIMEN BASED ACCURACY OF CAROTID STENOSIS EVALUATION
    David Saloner; Fiscal Year: 1999
    ..Improvements in the predictive value of diagnostic imaging will result in significant savings to the health care system by reducing unnecessary procedures, and by more appropriately selecting patients for surgery. ..
  20. EFFECTS OF TF/FVIIa INHIBITION IN CRP TRANSGENIC MICE
    Christopher Arnold; Fiscal Year: 2004
    ..Together, these models will help determine the in vivo anti-inflammatory and antithrombotic properties of BCX-3607, a potential agent for the treatment of acute coronary syndromes. ..
  21. CORONARY ARTERY BYPASS ENDARTERECTOMY STAGING TRIAL
    John Ricotta; Fiscal Year: 2002
    ..Conversely, a number of patients who present for surgical treatment of carotid stenosis, if screened, will have significant coronary artery disease...
  22. CEREBROVASCULAR TIME RESOLVED CONTRAST ENHANCED 3D MRA
    Patrick Turski; Fiscal Year: 1999
    ..4) Optimization of the dose of intravenous contrast material and the injection rate. (5) Implementation of these innovation for a blinded assessment of carotid stenosis measurement.
  23. Structure-Function Assessment of Carotid Disease by MR
    Felix Wehrli; Fiscal Year: 2004
    ..for measuring perfusion in a single vascular distribution to unambiguously assess the implications of carotid stenosis on blood flow to the affected hemisphere. 3...
  24. Assessing Microstructure of Carotid Disease with MRI/MRS
    Ronald Wolf; Fiscal Year: 2006
    ..will be initiated wherein symptomatic and asymptomatic patients (N = 50 each) with clinically significant carotid stenosis (>70%) who will subsequently undergo carotid endarterectomy (CEA) will be recruited...
  25. Characterization of Carotid Artery Flow
    TAMARA FITZGERALD; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Carotid angioplasty is a rapidly evolving endovascular treatment for carotid stenosis, and advocates predict that is will replace surgical endarterectomy...
  26. RECURRENT CAROTID STENOSIS
    EUGENE BERNSTEIN; Fiscal Year: 1990
    ....
  27. HOMOCYSTEINE AND PROGRESSION OF ATHEROSCLEROSIS
    Lloyd Taylor; Fiscal Year: 2002
    ..abstract_text> ..
  28. Flow responses to carotid angioplasty
    Alan Dardik; Fiscal Year: 2009
    ..Carotid angioplasty (CA) is a rapidly evolving endovascular treatment for carotid stenosis, preventing stroke...
  29. TRIAL OF LOVASTATIN AND ASPIRIN IN ATHEROSCLEROSIS
    Curt Furberg; Fiscal Year: 1992
    ..the progression of atherosclerotic plaques in the carotid arteries of high risk individuals with asymptomatic carotid stenosis. Men and women free of clinically evident coronary and cerebrovascualr disease who are 50 years of age or ..
  30. Quantitative Vascular Image Analysis system
    William Kerwin; Fiscal Year: 2009
    ..characterization methods of QVAS to generate a comprehensive risk score indicating whether a patient with carotid stenosis would benefit from surgical intervention such as carotid endarterectomy (CEA) or stenting...
  31. Study of Carotid Occlusion and Neurocognition (RECON)
    RANDOLPH MARSHALL; Fiscal Year: 2009
    ..We and others have further demonstrated cognitive improvement in case series studies of patients with carotid stenosis or occlusion treated with endarterectomy or extracranial-intracranial (EC-IC) bypass...
  32. APPARATUS FOR CEREBRAL BLOOD FLOW MEASUREMENTS AT 3T
    Lawrence Wald; Fiscal Year: 2001
    ..In addition, they will study these parameters in patients with moderate (50-70%) unilateral carotid stenosis. This will allow them to determine the percentage of blood flow to a given cortical voxel from each of the ..
  33. MECHANISMS OF FIBROUS CAP ATROPHY
    Michael Reidy; Fiscal Year: 2001
    ..These collaborative studies should provide novel insights into the basic mechanisms underlying fibrous cap atrophy and disruption. ..
  34. Two Coil Arterial Spin Labeling Cerebral Perfusion MRI
    Patrick Ledden; Fiscal Year: 2001
    ..We plan to make the two coil arterial spin labeling system available for the first time, to the over 200 neuroimaging research sites. We plan to pursue a clinical product based on the success of the "investigational use only" device. ..
  35. Magnetic Resonance Imaging of Vulnerable Plaque
    Thomas Hatsukami; Fiscal Year: 2006
    ..To achieve these goals, we will serially examine a cohort of subjects with moderate carotid stenosis to identify changes in the MRI appearance of the artery as it evolves from a clinically silent, stable plaque ..
  36. 3-D ULTRASOUND VASCULAR BLOOD FLOW MAPPING AND TRACKING
    Kenneth Abend; Fiscal Year: 2000
    ..track and lock onto selected vessels for spectral analysis and unattended monitoring, Applications include carotid stenosis, vascular graft evaluation for cardiac transplant, DVT, and hemodialysis...
  37. Development of Arterial Spin Labeling for Clinical Applications
    Eric Wong; Fiscal Year: 2009
    ..VSI is a new technique with a broad range of potential clinical applications including the evaluation of carotid stenosis, risk assessment for stroke, and the identification of tumor blood supplies...
  38. fMRI BOLD contrast relationship to cerebrovascular tone
    Todd Parrish; Fiscal Year: 2006
    ..When a subject has compromised vasculature and impaired vasoreactivity from a carotid stenosis or occlusion, we have demonstrated that the BOLD signal response is absent or severely altered beyond normal ..
  39. TISSUE ENGINEERING OF BLOOD VESSEL SUBSTITUTES
    Joseph Vacanti; Fiscal Year: 2002
    ..arteries constitute the lion's share of this, with diverse pathology ranging from coronary artery disease to carotid stenosis. The most widely applied surgical intervention for affected vascular structures is openly-performed "bypass" ..
  40. MRI IDENTIFICATION OF FIBROUS CAP ATROPHY AND RUPTURE
    Thomas Hatsukami; Fiscal Year: 2001
    ..We will also determine whether ischemic neurological events or plaque rupture assessed by histological evaluation of excised plaques correlates with fibrous cap thinning. ..
  41. Endothelial Progenitor Cells: Clinical Correlates and Prognosis in the Community
    Thomas Wang; Fiscal Year: 2009
    ..of EPC characteristics with subclinical measures of vascular structure (carotid intima-media thickness [IMT], carotid stenosis) and function (peripheral arterial tonometry, brachial flow-mediated dilation, vascular tonometry);and (3) To ..
  42. CEREBROVASCULAR RESEARCH CENTER
    James Toole; Fiscal Year: 1990
    ..unnoticed deficit arising from subtle compromise of CNS function in patients with TIA's and with asymptomatic carotid stenosis. 2. Studies of Vessel Disease...
  43. THE EFFECT OF HMG COA REDUCTASE INHIBITORS ON CBF
    COLIN DERDEYN; Fiscal Year: 2002
    ..Positive results from these experiments would support further investigation of a potentially important mechanism of stroke protection applicable to all patients with atherosclerotic coronary and cerebrovascular disease. ..
  44. The Role of Cerebral Hemodynamics in Moya Moya Disease
    COLIN PIETER DERDEYN; Fiscal Year: 2010
    ..We will perform a post-hoc longitudinal analysis of the effect of different medical treatment regimens. Patients will return annually for follow up PET studies. ..
  45. MIDCAREER INVESTIGATOR AWARD IN CEREBROVASCULAR RESEARCH
    Larry Goldstein; Fiscal Year: 2004
    ....
  46. Advanced NeuroImaging for Acute Stroke Treatment
    Max Wintermark; Fiscal Year: 2007
    ..Invited junior scientists, for whom funding is requested, were selected based on merit. [unreadable] [unreadable] [unreadable]..
  47. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  48. Homocysteine/Hypertension & Vascular Lesion Formation
    Peter Lin; Fiscal Year: 2008
    ..abstract_text> ..
  49. Genetic Determinants of Subclinical Carotid Disease
    Tatjana Rundek; Fiscal Year: 2008
    ..3. To explore a newly developed statistical method to evaluate the overall genetic effects from all candidate genes to obtain "whole-pathway" effects. ..
  50. FOOD FOLATE FORTIFICATION EFFECT ON FOLATE STATUS
    Jacob Selhub; Fiscal Year: 2001
    ..abstract_text> ..
  51. SECONDARY PREVENTION IN SMALL SUBCORTICAL STROKES (SPS3)
    Oscar Benavente; Fiscal Year: 2001
    ..abstract_text> ..
  52. MECHANISMS OF ENDOTHELIAL DYSFUNCTION IN DIABETICS
    Joshua Beckman; Fiscal Year: 2003
    ..abstract_text> ..
  53. Transcription Factors & Inflammatory Mediators in Stroke
    Raghu Vemuganti; Fiscal Year: 2007
    ..The ultimate goal is to define the role of SOCS-3/STAT-3 in post-ischemic cerebral inflammation. ..
  54. Measurement of folate in fortified cereal grain products
    Jacob Selhub; Fiscal Year: 2003
    ..In order to assess the impact of folic acid fortification, it is necessary to have valid data on the actual synthetic folic acid content of fortified foods. ..
  55. Progression of sub-clinical Atherosclerosis
    Joseph Polak; Fiscal Year: 2009
    ..This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers. ..
  56. Measuring the Efficacy of Endovascular Treatment of AAA
    Peter Faries; Fiscal Year: 2007
    ..abstract_text> ..
  57. Epidemiology of Carotid Intima-Medial Thickness (IMT) in Atherosclerosis
    Joseph Polak; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. Role of Egr-1 in post-stroke inflammation & brain damage
    Raghu Vemuganti; Fiscal Year: 2009
    ..The ultimate goal is to define the role of EgM and its regulators to develop therapies to control cerebral inflammation at the level of transcription. ..
  59. In Vivo Assessment of AAA Biomechanics with Dynamic Wall Properties
    ENDER FINOL; Fiscal Year: 2008
    ..This methodology is expected to greatly enhance the presurgical planning capabilities of vascular surgeries and endovascular therapies in the future management of cardiovascular diseases. [unreadable] [unreadable] [unreadable]..
  60. Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring Study
    Jacob Selhub; Fiscal Year: 2010
    ..5 About 3-5 percent of seniors have low circulating vitamin B12 levels;6 however, about 20 percent of seniors are found to be deficient when those with elevated methylmalonic acid levels are included. ..