intermittent claudication

Summary

Summary: A symptom complex characterized by leg pain and weakness brought on by walking, with the disappearance of the symptoms following a brief rest.

Top Publications

  1. pmc Symptomatic peripheral arterial disease: the value of a validated questionnaire and a clinical decision rule
    Bianca Lw Bendermacher
    Department of Surgery, Atrium Medical Centre, Heerlen, The Netherlands
    Br J Gen Pract 56:932-7. 2006
  2. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    J Vasc Surg 45:S5-67. 2007
  3. ncbi Peripheral arterial disease detection, awareness, and treatment in primary care
    A T Hirsch
    Vascular Medicine Program, Minnesota Vascular Diseases Center, Mayo Mail Code 508, University of Minnesota Medical School, 420 Delaware St, SE, Minneapolis, MN 55455, USA
    JAMA 286:1317-24. 2001
  4. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  5. ncbi Femoral plaque echogenicity and cardiovascular risk in claudicants
    Vittorio Schiano
    Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    JACC Cardiovasc Imaging 5:348-57. 2012
  6. ncbi Medical treatment of peripheral arterial disease
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth
    JAMA 295:547-53. 2006
  7. pmc Interspinous implants (X Stop, Wallis, Diam) for the treatment of LSS: is there a correlation between radiological parameters and clinical outcome?
    Rolf Sobottke
    Department of Orthopaedic and Trauma Surgery, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
    Eur Spine J 18:1494-503. 2009
  8. ncbi A multicenter, prospective, randomized trial evaluating the X STOP interspinous process decompression system for the treatment of neurogenic intermittent claudication: two-year follow-up results
    James F Zucherman
    St Mary s Hospital, San Francisco, California, USA
    Spine (Phila Pa 1976) 30:1351-8. 2005
  9. ncbi X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-up
    Björn H Strömqvist
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Skane University Hospital, Malmo, Sweden
    Spine (Phila Pa 1976) 38:1436-42. 2013
  10. ncbi Near-infrared spectroscopy assessment following exercise training in patients with intermittent claudication and in untrained healthy participants
    Fabio Manfredini
    Vascular Diseases Center, University of Ferrara, Italy
    Vasc Endovascular Surg 46:315-24. 2012

Detail Information

Publications313 found, 100 shown here

  1. pmc Symptomatic peripheral arterial disease: the value of a validated questionnaire and a clinical decision rule
    Bianca Lw Bendermacher
    Department of Surgery, Atrium Medical Centre, Heerlen, The Netherlands
    Br J Gen Pract 56:932-7. 2006
    If a validated questionnaire, when applied to patients reporting with symptoms of intermittent claudication, could adequately discriminate between those with and without peripheral arterial disease, GPs could avoid the diagnostic ..
  2. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    J Vasc Surg 45:S5-67. 2007
  3. ncbi Peripheral arterial disease detection, awareness, and treatment in primary care
    A T Hirsch
    Vascular Medicine Program, Minnesota Vascular Diseases Center, Mayo Mail Code 508, University of Minnesota Medical School, 420 Delaware St, SE, Minneapolis, MN 55455, USA
    JAMA 286:1317-24. 2001
    ..Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis that is common and is associated with an increased risk of death and ischemic events, yet may be underdiagnosed in primary care practice...
  4. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  5. ncbi Femoral plaque echogenicity and cardiovascular risk in claudicants
    Vittorio Schiano
    Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    JACC Cardiovasc Imaging 5:348-57. 2012
    ..The present study was designed to verify whether the evaluation of femoral plaque echogenicity might be a useful tool for cardiovascular risk assessment in patients affected by lower extremity peripheral arterial disease...
  6. ncbi Medical treatment of peripheral arterial disease
    Graeme J Hankey
    Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth
    JAMA 295:547-53. 2006
    ..The goals of treatment are to prevent future major coronary and cerebrovascular events and improve leg symptoms...
  7. pmc Interspinous implants (X Stop, Wallis, Diam) for the treatment of LSS: is there a correlation between radiological parameters and clinical outcome?
    Rolf Sobottke
    Department of Orthopaedic and Trauma Surgery, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
    Eur Spine J 18:1494-503. 2009
    Neurogenic intermittent claudication, caused by lumbar spinal stenosis (LSS), usually occurs after the age of 50 and is one of the most common degenerative spinal diseases in the elderly...
  8. ncbi A multicenter, prospective, randomized trial evaluating the X STOP interspinous process decompression system for the treatment of neurogenic intermittent claudication: two-year follow-up results
    James F Zucherman
    St Mary s Hospital, San Francisco, California, USA
    Spine (Phila Pa 1976) 30:1351-8. 2005
    A randomized, controlled, prospective multicenter trial comparing the outcomes of neurogenic intermittent claudication (NIC) patients treated with the interspinous process decompression system (X STOP) with patients treated nonoperatively.
  9. ncbi X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-up
    Björn H Strömqvist
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Skane University Hospital, Malmo, Sweden
    Spine (Phila Pa 1976) 38:1436-42. 2013
    ..Prospective randomized controlled study...
  10. ncbi Near-infrared spectroscopy assessment following exercise training in patients with intermittent claudication and in untrained healthy participants
    Fabio Manfredini
    Vascular Diseases Center, University of Ferrara, Italy
    Vasc Endovascular Surg 46:315-24. 2012
    ..The assessment of NIRS parameters, that were found stable without training in healthy and modified in PAD only following structured training, might outline the local exercise-induced adaptations...
  11. ncbi A new pharmacological treatment for intermittent claudication: results of a randomized, multicenter trial
    H G Beebe
    Jobst Vascular Center, Toledo, Ohio 43606, USA
    Arch Intern Med 159:2041-50. 1999
    Effective medication is limited for the relief of intermittent claudication, a common manifestation of arterial occlusive disease. Cilostazol is a potent inhibitor of platelet aggregation with vasodilation effects.
  12. ncbi Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication
    Antonio Silvestro
    Department of Medicine, University of Naples Federico II, Naples, Italy
    Atherosclerosis 165:277-83. 2002
    In patients with intermittent claudication, exercise is associated with a marked increase in oxidative stress, likely responsible for systemic endothelial perturbation...
  13. ncbi Leg symptoms in peripheral arterial disease: associated clinical characteristics and functional impairment
    M M McDermott
    Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    JAMA 286:1599-606. 2001
    Persons with lower-extremity peripheral arterial disease (PAD) are often asymptomatic or have leg symptoms other than intermittent claudication (IC).
  14. ncbi The reliability of the Shuttle Walking Test, the Swiss Spinal Stenosis Questionnaire, the Oxford Spinal Stenosis Score, and the Oswestry Disability Index in the assessment of patients with lumbar spinal stenosis
    Roland K Pratt
    Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom
    Spine (Phila Pa 1976) 27:84-91. 2002
    ....
  15. ncbi The effects of an interspinous implant on the kinematics of the instrumented and adjacent levels in the lumbar spine
    Derek P Lindsey
    VA Rehab R and D Center, Palo Alto, CA, USA
    Spine (Phila Pa 1976) 28:2192-7. 2003
    ..Measurement of the kinematics of the lumbar spine after insertion of an interspinous spacer in vitro...
  16. ncbi Myeloscopic study on lumbar spinal canal stenosis with special reference to intermittent claudication
    Y Ooi
    Jichi Medical School, Department of Orthopaedic Surgery, Kawachi gun, Tochigi, Japan
    Spine (Phila Pa 1976) 15:544-9. 1990
    ..canal stenosis were investigated by dynamic myeloscopy to explain the pathophysiologic mechanism of intermittent claudication, one of the characteristic signs of the disorder...
  17. ncbi Exercise-based interventions and health-related quality of life in intermittent claudication: a 20-year (1989-2008) review
    Marie Guidon
    School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 17:140-54. 2010
    ..Symptoms include pain in leg muscles on walking, relieved by rest (intermittent claudication)...
  18. ncbi The treatment mechanism of an interspinous process implant for lumbar neurogenic intermittent claudication
    Joshua C Richards
    San Francisco Orthopaedic Residency Program, University of California, USA
    Spine (Phila Pa 1976) 30:744-9. 2005
    ..The spinal canal and neural foramina dimensions of cadaver lumbar spines were quantified during flexion and extension using magnetic resonance imaging before and after placement of an interspinous process implant...
  19. ncbi A systematic review to evaluate the effectiveness of carnitine supplementation in improving walking performance among individuals with intermittent claudication
    Christopher L Delaney
    Department of Vascular Surgery, Flinders University, Australia
    Atherosclerosis 229:1-9. 2013
    To evaluate the evidence for the use of carnitine supplementation in improving walking performance among individuals with intermittent claudication.
  20. pmc Multifactorial determinants of functional capacity in peripheral arterial disease: uncoupling of calf muscle perfusion and metabolism
    Justin D Anderson
    Department of Medicine, University of Virginia Health System, University of Virginia, Charlottesville, VA 22908, USA
    J Am Coll Cardiol 54:628-35. 2009
    ..We aimed to investigate the pathophysiology of peripheral arterial disease (PAD) by examining magnetic resonance imaging (MRI) and spectroscopic (MRS) correlates of functional capacity...
  21. pmc Efficacy of quantified home-based exercise and supervised exercise in patients with intermittent claudication: a randomized controlled trial
    Andrew W Gardner
    CMRI Diabetes and Metabolic Research Program, Harold Hamm Oklahoma Diabetes Center, Oklahoma University Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK 73117, USA
    Circulation 123:491-8. 2011
    ..trial compared changes in exercise performance and daily ambulatory activity in peripheral artery disease patients with intermittent claudication after a home-based exercise program, a supervised exercise program, and usual-care control.
  22. pmc Clinical evaluation of the preliminary safety and effectiveness of a minimally invasive interspinous process device APERIUS(®) in degenerative lumbar spinal stenosis with symptomatic neurogenic intermittent claudication
    Jan Van Meirhaeghe
    Dienst Orthopedie en Traumatologie, AZ Sint Jan Brugge Oostende AV, Ruddershove 10, 8000 Brugge, Belgium
    Eur Spine J 21:2565-72. 2012
    ..provide an alternative to conservative treatment and decompressive surgery for patients with neurogenic intermittent claudication (NIC) due to degenerative lumbar spinal stenosis (DLSS)...
  23. ncbi The effect of exercise on haemodynamics in intermittent claudication: a systematic review of randomized controlled trials
    Belinda J Parmenter
    Exercise, Health and Performance Faculty Research Group, Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia
    Sports Med 40:433-47. 2010
    ..studies included randomized controlled trials using an exercise intervention for the treatment of intermittent claudication with haemodynamic measures of disease severity as outcomes...
  24. ncbi Randomized clinical trial of percutaneous transluminal angioplasty, supervised exercise and combined treatment for intermittent claudication due to femoropopliteal arterial disease
    F A K Mazari
    Academic Vascular Surgical Unit, University of Hull, Hull, UK
    Br J Surg 99:39-48. 2012
    The aim was to compare percutaneous transluminal angioplasty (PTA), a supervised exercise programme (SEP) and combined treatment (PTA plus SEP) for intermittent claudication due to femoropopliteal arterial disease.
  25. pmc Corridor-based functional performance measures correlate better with physical activity during daily life than treadmill measures in persons with peripheral arterial disease
    Mary M McDermott
    Departments of Medicine and Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Vasc Surg 48:1231-7, 1237.e1. 2008
    ..To compare associations of physical activity during daily life with treadmill walking performance and corridor-based functional performance measures in persons with lower extremity peripheral arterial disease (PAD)...
  26. ncbi Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication
    Mark A Creager
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 124:1765-73. 2011
    ..intramuscular administration of Ad2/HIF-1α/VP16, an engineered recombinant type 2 adenovirus vector encoding constitutively active HIF-1α, improves walking time in patients with peripheral artery disease and intermittent claudication.
  27. pmc Effectiveness of interspinous implant surgery in patients with intermittent neurogenic claudication: a systematic review and meta-analysis
    Wouter A Moojen
    Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
    Eur Spine J 20:1596-606. 2011
    ..The main objective of this review was to perform a meta-analysis of all systematic reviews, randomized clinical trials and prospective cohort series to quantify the effectiveness of IPDs and to evaluate the potential side-effects...
  28. ncbi The adjuvant benefit of angioplasty in patients with mild to moderate intermittent claudication (MIMIC) managed by supervised exercise, smoking cessation advice and best medical therapy: results from two randomised trials for stenotic femoropopliteal and
    R M Greenhalgh
    Imperial College London, Vascular Surgery Research Group, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
    Eur J Vasc Endovasc Surg 36:680-8. 2008
    Uncertainty exists on whether there is adjuvant benefit of percutaneous transluminal angioplasty (PTA) over supervised exercise and best medical therapy in the treatment of intermittent claudication.
  29. ncbi Limb-specific and cross-transfer effects of arm-crank exercise training in patients with symptomatic peripheral arterial disease
    Garry Tew
    Centre for Sport and Exercise Science, Sheffield Hallam University, UK
    Clin Sci (Lond) 117:405-13. 2009
    Arm cranking is a useful alternative exercise modality for improving walking performance in patients with intermittent claudication; however, the mechanisms of such an improvement are poorly understood...
  30. ncbi Asymptomatic peripheral arterial disease is associated with more adverse lower extremity characteristics than intermittent claudication
    Mary M McDermott
    Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    Circulation 117:2484-91. 2008
    ..This study assessed functional performance, calf muscle characteristics, peripheral nerve function, and quality of life in asymptomatic persons with peripheral arterial disease (PAD)...
  31. ncbi Quality of life in patients with intermittent claudication using the World Health Organisation (WHO) questionnaire
    J C Breek
    Department of Surgery, St. Elisabeth Hospital, Tilburg, The Netherlands
    Eur J Vasc Endovasc Surg 21:118-22. 2001
    OBJECTIVE: to assess quality of life (QOL) in patients with intermittent claudication. DESIGN: a prospective, open study...
  32. ncbi Treating intermittent claudication with Tibetan medicine Padma 28: does it work?
    Jörg Melzer
    Department of Internal Medicine, Complementary Medicine, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Atherosclerosis 189:39-46. 2006
    ..e. walking distance), probably of the same order of magnitude as other employed medications. However, larger confirmatory RCTs are desirable...
  33. ncbi Association of obesity and metabolic syndrome with the severity and outcome of intermittent claudication
    Jonathan Golledge
    Vascular Biology Unit, James Cook University, Townsville, Queensland, Australia
    J Vasc Surg 45:40-6. 2007
    ..The aim of this study was to assess the association between obesity and the severity and outcome of intermittent claudication.
  34. ncbi Exercise therapy and the additional effect of supervision on exercise therapy in patients with intermittent claudication. Systematic review of randomised controlled trials
    J Wind
    Tergooiziekenhuizen, location Hilversum, Department of Surgery, The Netherlands
    Eur J Vasc Endovasc Surg 34:1-9. 2007
    To review the evidence for the effectiveness of exercise therapy and to estimate the additional effect of supervision on exercise therapy in patients with intermittent claudication.
  35. ncbi Translation and validation of the walking impairment questionnaire in Brazilian subjects with intermittent claudication
    Raphael Mendes Ritti-Dias
    Faculdade de Saude Publica, USP, Sao Paulo, SP, Brazil
    Arq Bras Cardiol 92:136-49. 2009
    The Walking Impairment Questionnaire (WIQ) has been used to evaluate walking impairment in subjects with intermittent claudication (IC)...
  36. ncbi Peripheral arterial disease: comparison of color duplex US and contrast-enhanced MR angiography for diagnosis
    Tim Leiner
    Departments of Radiology, Clinical Epidemiology and Medical Technology Assessment, Epidemiology, and Vascular Surgery, Maastricht University Hospital, Peter Debijelaan 25, NL 6229 HX Maastricht, The Netherlands
    Radiology 235:699-708. 2005
    ....
  37. ncbi Multicenter randomized clinical trial of supervised exercise therapy with or without feedback versus walking advice for intermittent claudication
    Saskia P A Nicolaï
    Department of Surgery at Atrium Medical Center Parkstad, Heerlen, The Netherlands
    J Vasc Surg 52:348-55. 2010
    The initial treatment for intermittent claudication is supervised exercise therapy (SET). Owing to limited capacity and patient transports costs of clinic-based SET, a concept of SET provided by local physiotherapists was developed...
  38. ncbi The effects of including quality of life responses in models to predict walking performance of patients with intermittent claudication
    A S Leicht
    Institute of Sport and Exercise Science, James Cook University, Townsville, Queensland 4811, Australia
    Eur J Vasc Endovasc Surg 41:511-7. 2011
    ..the accuracy of previously developed prediction models of treadmill walking performance in patients with intermittent claudication (IC) due to peripheral arterial disease (PAD); and to examine the accuracy of new prediction models.
  39. ncbi When is supervised exercise therapy considered useful in peripheral arterial occlusive disease? A nationwide survey among vascular surgeons
    G J Lauret
    Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands
    Eur J Vasc Endovasc Surg 43:308-12. 2012
    ..guidelines state that supervised exercise therapy (SET) should be offered to all patients with intermittent claudication (IC), SET appears to be underutilised in clinical practice...
  40. pmc Two-year results of interspinous spacer (X-Stop) implantation in 175 patients with neurologic intermittent claudication due to lumbar spinal stenosis
    Johannes Kuchta
    Department of Neurosurgery, MediaParc Clinic, Cologne, Germany
    Eur Spine J 18:823-9. 2009
    ..The X-Stop is the most commonly used interspinous distraction device in patients with neurogenic intermittent claudication due to LSS...
  41. pmc Insertion loads of the X STOP interspinous process distraction system designed to treat neurogenic intermittent claudication
    Vikram Talwar
    San Francisco Orthopaedic Residency Program, CA, USA
    Eur Spine J 15:908-12. 2006
    An interspinous process implant has been developed to treat patients suffering from neurogenic intermittent claudication secondary to lumbar spinal stenosis...
  42. ncbi Detection of peripheral vascular stenosis by assessing skeletal muscle flow reserve
    Thanjuvar Bragadeesh
    Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia
    J Am Coll Cardiol 45:780-5. 2005
    ..We sought to determine whether the severity of peripheral arterial disease (PAD) can be assessed by measuring blood flow reserve in limb skeletal muscle with contrast-enhanced ultrasound (CEU)...
  43. pmc Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study
    A St-Pierre
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec City, Canada
    Can J Cardiol 26:17-21. 2010
    The natural history of intermittent claudication, from its risk factors to its cardiovascular prognosis, has been reported in few prospective studies.
  44. ncbi Exercise training for claudication
    Kerry J Stewart
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 347:1941-51. 2002
  45. ncbi Magnetic resonance imaging in peripheral arterial disease: reproducibility of the assessment of morphological and functional vascular status
    Bas Versluis
    Department of Radiology, Maastricht University Medical Center MUMC, Maastricht, The Netherlands
    Invest Radiol 46:11-24. 2011
    ....
  46. ncbi Effects of cilostazol on resting ankle pressures and exercise-induced ischemia in patients with intermittent claudication
    E R Mohler
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Vasc Med 6:151-6. 2001
    During exercise, patients with intermittent claudication (IC) have decreased limb arterial blood pressure that recovers during rest...
  47. ncbi Postoperative outcomes for patients undergoing elective revascularization for critical limb ischemia and intermittent claudication: a subanalysis of the Coronary Artery Revascularization Prophylaxis (CARP) trial
    Amritha Raghunathan
    Vascular Surgery Service, San Francisco VA Medical Center and Univ of California at San Francisco, CA 94121, USA
    J Vasc Surg 43:1175-82. 2006
    ..rate, and long-term survival of patients with critical limb ischemia (CLI) compared with those with intermittent claudication (IC) within a cohort selected for significant coronary artery disease, a secondary analysis was ..
  48. ncbi Intermittent claudication: an overview
    Ashwinkumar V Meru
    New Drug Discovery Research, Department of Pharmacology, Ranbaxy Laboratories Limited, R and D, Plot 20, Sector 18, Udyog Vihar Industrial Area, Gurgaon 122001, Haryana, India
    Atherosclerosis 187:221-37. 2006
    b>Intermittent claudication (IC) is defined by leg muscle pain, cramping and fatigue brought on by ambulation/exercise; relieved on rest; and caused by inadequate blood supply and is the primary symptom of peripheral arterial disease (PAD)...
  49. ncbi Strength training increases walking tolerance in intermittent claudication patients: randomized trial
    Raphael Mendes Ritti-Dias
    School of Physical Education, University of Pernambuco, Pernambuco, Brazil
    J Vasc Surg 51:89-95. 2010
    To analyze the effects of strength training (ST) in walking capacity in patients with intermittent claudication (IC) compared with walking training (WT) effects.
  50. pmc Gender differences in daily ambulatory activity patterns in patients with intermittent claudication
    Andrew W Gardner
    CMRI Diabetes and Metabolic Research Program, Harold Hamm Oklahoma Diabetes Center, Oklahoma University Health Sciences Center OUHSC, Department of Boistatistics and Epidemiology, Oklahoma City, OK 73117, USA
    J Vasc Surg 52:1204-10. 2010
    To compare the pattern of daily ambulatory activity in men and women with intermittent claudication, and to determine whether calf muscle hemoglobin oxygen saturation (StO2) is associated with daily ambulatory activity.
  51. pmc A pooled analysis of the durability and predictors of treatment response of cilostazol in patients with intermittent claudication
    Reena L Pande
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 15:181-8. 2010
    Pharmacologic therapy for intermittent claudication in patients with peripheral artery disease (PAD) is limited...
  52. ncbi Cilostazol has beneficial effects in treatment of intermittent claudication: results from a multicenter, randomized, prospective, double-blind trial
    D L Dawson
    Department of Surgery, University of Washington, Seattle, USA
    Circulation 98:678-86. 1998
    ..This prospective, randomized, placebo-controlled, parallel-group clinical trial evaluated the efficacy of cilostazol for treatment of stable, moderately severe intermittent claudication.
  53. ncbi Effective training for patients with intermittent claudication
    Stig A Slørdahl
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Scand Cardiovasc J 39:244-9. 2005
    Current guidelines for treatment of intermittent claudication (IC) do not include a specific recommendation for the intensity of exercise therapy...
  54. ncbi Reduction of remnant lipoprotein cholesterol concentrations by cilostazol in patients with intermittent claudication
    Tao Wang
    Otsuka America Pharmaceutical Inc, Rockville, MD, USA
    Atherosclerosis 171:337-42. 2003
    ..lipoproteins and reduced high-density lipoproteins (HDL) are associated with the development of intermittent claudication (IC), a life-limiting symptom of peripheral arterial disease...
  55. ncbi Relationship between temporal-spatial gait parameters, gait kinematics, walking performance, exercise capacity, and physical activity level in peripheral arterial disease
    Robert G Crowther
    Institute of Sport and Exercise Science, James Cook University, Townsville Hospital, Queensland, Australia
    J Vasc Surg 45:1172-8. 2007
    ..function is a feature of patients with peripheral arterial disease (PAD) who present with symptoms of intermittent claudication (PAD-IC)...
  56. ncbi Cost-effectiveness targets for multi-detector row CT angiography in the work-up of patients with intermittent claudication
    Karen Visser
    Program for the Assessment of Radiological Technology, Department of Epidemiology and Biostatistics, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, Rm Ee21 40B, 3015GE Rotterdam, The Netherlands
    Radiology 227:647-56. 2003
    ..multi-detector row computed tomographic (CT) angiography results in the work-up of patients with intermittent claudication that would make this imaging examination cost-effective compared with gadolinium-enhanced magnetic ..
  57. ncbi [Antiischemic efficacy of trimetazidine in patients with intermittent claudication and effort angina]
    A L Syrkin
    Moskovskaia meditsinskaia akademiia im I M Sechenova, Moskva
    Kardiologiia 43:49-52. 2003
    ..Statistically significant decreases of frequency of attacks of angina, nitroglycerine consumption and increases of walking distance occurred only in group 1...
  58. ncbi Improvement of the walking ability in intermittent claudication due to superficial femoral artery occlusion with supervised exercise and pneumatic foot and calf compression: a randomised controlled trial
    S K Kakkos
    Vascular Unit, Ealing Hospital, Southall, Middlesex, UK
    Eur J Vasc Endovasc Surg 30:164-75. 2005
    ..of unsupervised exercise, supervised exercise and intermittent pneumatic foot and calf compression (IPC) on the claudication distance, lower limb arterial haemodynamics and quality of life of patients with intermittent claudication.
  59. ncbi Percutaneous angioplasty of the superior gluteal artery for buttock claudication: a report of seven cases and literature review
    Michel Batt
    Department of Vascular Surgery, Hopital Saint Roch, Nice, France
    J Vasc Surg 43:987-91. 2006
    ....
  60. ncbi Cilostazol: treatment of intermittent claudication
    M P Reilly
    Cardiovascular Division, Department of Medicine, School of Medicine, University of Pennsylvania, 432 PHI Bldg, 51 North 39th St, Philadelphia, PA 19104-2699, USA
    Ann Pharmacother 35:48-56. 2001
    ..and clinical utility of cilostazol, an antiplatelet and vasodilator agent approved for the management of intermittent claudication. DATA SOURCES: Primary literature on cilostazol was identified from a comprehensive MEDLINE literature ..
  61. ncbi Reliability of treadmill testing in peripheral arterial disease: a meta-regression analysis
    Saskia P A Nicolaï
    Department of Surgery, Atrium Medical Center Parkstad, Heerlen, The Netherlands
    J Vasc Surg 50:322-9. 2009
    ..A meta-regression analysis was conducted to identify the most reliable treadmill protocol for the assessment of patients with peripheral arterial disease (PAD)...
  62. ncbi β-Blockers in patients with intermittent claudication and arterial hypertension: results from the nebivolol or metoprolol in arterial occlusive disease trial
    Christine Espinola-Klein
    Department of Medicine II, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Hypertension 58:148-54. 2011
    ..A total of 128 patients with intermittent claudication and essential hypertension were included and double-blind randomized to receive 5 mg of nebivolol (N=65) ..
  63. ncbi Nordic poles immediately improve walking distance in patients with intermittent claudication
    C Oakley
    Centre for Sport and Exercise Science, Sheffield Hallam University, Collegiate Crescent Campus, Sheffield, S10 2BP, UK
    Eur J Vasc Endovasc Surg 36:689-94; discussion 695-6. 2008
    To investigate the immediate effects of Nordic pole walking (NPW) on walking distance and cardiopulmonary workload in patients with intermittent claudication.
  64. pmc Results for primary bypass versus primary angioplasty/stent for intermittent claudication due to superficial femoral artery occlusive disease
    Jeffrey J Siracuse
    Division of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02210, USA
    J Vasc Surg 55:1001-7. 2012
    ..However, long-term results comparing these modalities for primary intervention in patients who have had no prior intervention have not been reported. We report our results with 3-year follow-up...
  65. ncbi Secondhand smoke exposure and intermittent claudication: a Scotland-wide study of 4231 non-smokers
    Liya Lu
    Department of Public Health, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
    Heart 99:1342-5. 2013
    ..In contrast, published evidence on the association with secondhand smoke (SHS) is very limited. The aim of this study was to examine the association between SHS exposure and intermittent claudication (IC) among middle aged non-smokers.
  66. ncbi Intermittent claudication: clinical effectiveness of endovascular revascularization versus supervised hospital-based exercise training--randomized controlled trial
    Sandra Spronk
    Department of Surgery, Vascular Laboratory, Ikazia Hospital, Rotterdam, The Netherlands
    Radiology 250:586-95. 2009
    To compare clinical success, functional capacity, and quality of life during 12 months after revascularization or supervised exercise training in patients with intermittent claudication.
  67. ncbi Gait variability of patients with intermittent claudication is similar before and after the onset of claudication pain
    Sara A Myers
    Nebraska Biomechanics Core Facility, University of Nebraska at Omaha, Omaha, NE 68182 0216, USA
    Clin Biomech (Bristol, Avon) 26:729-34. 2011
    Recent research demonstrated that intermittent claudication patients have increased gait variability prior to the onset of claudication...
  68. ncbi Treadmill test is limited in elderly patients with peripheral arterial disease
    N Wolosker
    School of Physical Education, University of Pernambuco, Santo Amaro, BR Recife, Brazil
    Vasa 39:237-41. 2010
    ..To describe the applicability and the performance of the treadmill test in elderly patients with peripheral arterial disease (PAD) and without PAD (non-PAD)...
  69. ncbi Effects of policosanol and ticlopidine in patients with intermittent claudication: a double-blinded pilot comparative study
    Gladys Castaño
    Medical Surgical Research Center, Havana City, Cuba
    Angiology 55:361-71. 2004
    ..was undertaken to compare the effects of policosanol and ticlopidine in patients with moderately severe intermittent claudication (IC)...
  70. ncbi Cystic adventitial disease: a case report and literature review
    Arvind Vasudevan
    Department of Vascular Surgery, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    ANZ J Surg 75:1120-2. 2005
    ..A literature review revealed the different theories for pathogenesis, the investigation of choice being catheter angiography and the treatment excision with bypass grafting...
  71. ncbi Late effects of a brief psychological intervention in patients with intermittent claudication in a randomized clinical trial
    M A Cunningham
    Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia
    Br J Surg 100:756-60. 2013
    ..results of a trial of a brief psychological intervention to increase physical activity in patients with intermittent claudication. After 4 months, participants in the intervention group walked a mean of 1576 more steps per day than ..
  72. ncbi Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial
    Anna A Ahimastos
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria, 8008 Australia
    JAMA 309:453-60. 2013
    Approximately one-third of patients with peripheral artery disease experience intermittent claudication, with consequent loss of quality of life.
  73. ncbi Prediction of intermittent claudication, ischemic stroke, and other cardiovascular disease by detection of abdominal aortic calcific deposits by plain lumbar radiographs
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 101:326-31. 2008
    ..to vascular calcium testing for generalized assessment of cardiovascular disease (CVD) outcomes, such as intermittent claudication (IC) and ischemic stroke (IS)...
  74. ncbi Pain threshold is achieved at intensity above anaerobic threshold in patients with intermittent claudication
    Raphael Mendes Ritti-Dias
    Department of Nutrition, School of Public Health, Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
    J Cardiopulm Rehabil Prev 29:396-401. 2009
    ..training is considered as the first treatment option for patients with peripheral arterial disease and intermittent claudication (IC)...
  75. ncbi Incidence and management of intermittent claudication in primary care in The Netherlands
    Wouter T Meijer
    Department of General Practice, Erasmus Medical Center Rotterdam, The Netherlands
    Scand J Prim Health Care 20:33-4. 2002
    To study the incidence and management of intermittent claudication in primary care.
  76. ncbi Estimation of the functional role of arterial pathways to the buttock circulation during treadmill walking in patients with claudication
    Vincent Jaquinandi
    Physiologie, Explorations Fonctionnelles Vasculaires et d Effort and Laboratoire de Physiologie, UMR Centre National de la Recherche Scientifique 6214, Institut National de la Santé de la Recherche Médicale 771, 49933 Angers Cedex 9, France
    J Appl Physiol 102:1105-12. 2007
    ..Distal Ptc(O(2)) decrease at exercise aggravates proximal Ptc(O(2)) decrease, possibly through the occurrence of a "steal phenomenon" of distal over proximal circulation during walking...
  77. ncbi Neurogenic intermittent claudication in lumbar spinal canal stenosis: the clinical relationship between the local pressure of the intervertebral foramen and the clinical findings in lumbar spinal canal stenosis
    Yuichiro Morishita
    Department of Orthopaedic Surgery, Fukuoka University, Jyonan ku, Fukuoka, Japan
    J Spinal Disord Tech 22:130-4. 2009
    ..The clinical relationship between the local pressure of the intervertebral foramen and the clinical findings in lumbar spinal canal stenosis were evaluated...
  78. ncbi Natural history of physical function in older men with intermittent claudication
    Andrew W Gardner
    Department of Health and Sport Sciences, University of Oklahoma, Norman 73019, USA
    J Vasc Surg 40:73-8. 2004
    This study was undertaken to determine the natural history of physical function in older men limited by intermittent claudication.
  79. ncbi Beneficial effects of exercise beyond the pain threshold in intermittent claudication
    Roberto Carlon
    Cardiovascular Department, Cittadella Hospital, Azienda ASSL 15 Alta Padovana, Cittadella, PD, Italy
    Ital Heart J 4:113-20. 2003
    The quality of life and autonomy may be severely hampered in patients with intermittent claudication, but the amputation rate is very low. Supervised exercise training is effective, but still very rarely employed...
  80. ncbi Percutaneous transluminal angioplasty of infrapopliteal arteries in patients with intermittent claudication: acute and one-year results
    Hans Krankenberg
    Center for Cardiology and Vascular Intervention, Hamburg, Germany
    Catheter Cardiovasc Interv 64:12-7. 2005
    ..In contrast, PTA is currently not the therapy of choice in intermittent claudication (IC). In this prospective study, patients with IC were treated percutaneously...
  81. ncbi Successful lower extremity angioplasty improves brachial artery flow-mediated dilation in patients with peripheral arterial disease
    Marc Husmann
    Cardiovascular Department, Division of Clinical and Interventional Angiology, University Hospital Berne and University of Berne, Berne, Switzerland
    J Vasc Surg 48:1211-6. 2008
    ..We assumed that endovascular revascularization of lower limb arterial obstructions ameliorates FMD and lowers inflammation through improvement of peripheral perfusion...
  82. ncbi Interobserver variability of ankle-brachial index measurements at rest and post exercise in patients with intermittent claudication
    Herman van Langen
    Vascular Laboratory, VieCuri Medical Centre, Venlo, The Netherlands
    Vasc Med 14:221-6. 2009
    ..index (ABI) post exercise is claimed to play a complementary role in the diagnosis or exclusion of intermittent claudication (IC)...
  83. ncbi Efficacy and safety of cilostazol, a novel phosphodiesterase inhibitor in patients with intermittent claudication
    Shivpreet S Samra
    St George s Hospital, Mumbai 400001
    J Indian Med Assoc 101:561-2, 564. 2003
    Pharmacotherapy is limited for the relief of intermittent claudication (IC), a common manifestation of peripheral arterial disease (PAD)...
  84. pmc Walking exercise in patients with intermittent claudication. Experience in routine clinical practice
    Marie Louise Bartelink
    University Medical Centre Utrecht, Julius Center for Health Sciences and Primary Care Utrecht, The Netherlands
    Br J Gen Pract 54:196-200. 2004
    In patients with intermittent claudication, exercise in the form of walking is effective in reducing pain and maximising achievable walking distance. However, data are lacking on the implementation of walking exercise in these patients.
  85. ncbi An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease
    Fayyaz Ali Khan Mazari
    Academic Vascular Surgical Unit, University of Hull, Vascular Laboratory, Alderson House, Hull Royal Infirmary, Hull, United Kingdom
    J Vasc Surg 52:77-84. 2010
    ..To establish the relationship between quality of life (QOL) index scores and clinical indicators of lower limb ischemia...
  86. pmc Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training
    W Schuyler Jones
    Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    Vasc Med 17:94-100. 2012
    ..These somewhat unexpected findings suggest that further investigation into the mechanism of vascular responses to exercise training in PAD patients is warranted...
  87. ncbi Physical training for intermittent claudication: a comparison of structured rehabilitation versus home-based training
    Steve Degischer
    Department of Angiology, University of Basel Medical School, Switzerland
    Vasc Med 7:109-15. 2002
    ..0-385.7 m], for ACD and ICD, respectively. Structured, supervised PAD rehabilitation is a highly efficacious treatment for intermittent claudication and may be regarded as the present gold standard among conservative treatment options.
  88. ncbi Drug therapy for improving walking distance in intermittent claudication: a systematic review and meta-analysis of robust randomised controlled studies
    A H Momsen
    Department of Surgery, Regional Hospital Herning, Denmark
    Eur J Vasc Endovasc Surg 38:463-74. 2009
    ..interventions in improving walking capacity and health-related quality of life for people with intermittent claudication. DATASOURCES: We searched Medline, EMBASE, Cochrane library and relevant websites for studies published ..
  89. ncbi Blood pressure in patients with intermittent claudication increases continuously during walking
    E F Bakke
    Department of Vascular Diagnosis and Research, Oslo Vascular Centre, Aker University Hospital, University of Oslo, Oslo, Norway
    Eur J Vasc Endovasc Surg 33:20-5. 2007
    ..The purpose of this study was to compare the circulatory responses to walking in patients with peripheral atherosclerotic disease (PAD) and healthy controls...
  90. ncbi Effects of supervised treadmill walking training on calf muscle capillarization in patients with intermittent claudication
    Jianxiong Wang
    Department of Exercise Science and Sport Management, Southern Cross University, Lismore, Australia
    Angiology 60:36-41. 2009
    ..the effects of supervised treadmill walking training on the calf muscle capillarization in patients with intermittent claudication. The first 12-week period was a non-exercise, within-subject control stage, and the second 12-week ..
  91. ncbi Supervised exercise therapy for intermittent claudication: current status and future perspectives
    Gert Jan Lauret
    Department of Vascular Surgery, Catharina Hospital, PO Box 1350, 5602 ZA, Eindhoven
    Vascular 20:12-9. 2012
    b>Intermittent claudication (IC) has a high prevalence in the older population and is closely associated with cardiovascular and cerebrovascular disease. High mortality rates are reported due to ongoing atherosclerotic disease...
  92. ncbi Supervised walking therapy in patients with intermittent claudication
    Farzin Fakhry
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Vasc Surg 56:1132-42. 2012
    Exercise therapy is a common intervention for the management of intermittent claudication (IC)...
  93. ncbi The outback catheter: a new device for true lumen re-entry after dissection during recanalization of arterial occlusions
    Klaus A Hausegger
    Department of Radiology, University Hospital Graz, Auenbruggerplatz 9, 8036 Graz, Austria
    Cardiovasc Intervent Radiol 27:26-30. 2004
    ....
  94. ncbi Medical management of peripheral arterial disease: a therapeutic algorithm
    Alan B Lumsden
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Endovasc Ther 13:II19-29. 2006
    ..The most common symptom of mild-to-moderate PAD is intermittent claudication, present in about one third of symptomatic patients...
  95. ncbi Inhibition of adenosine uptake and augmentation of ischemia-induced increase of interstitial adenosine by cilostazol, an agent to treat intermittent claudication
    Y Liu
    Maryland Research Laboratories, Otsuka America Pharmaceutical Inc, Rockville 20850, USA
    J Cardiovasc Pharmacol 36:351-60. 2000
    ..activity, was recently approved by the Food and Drug Administration for treatment of symptoms of intermittent claudication (IC). However, the underlying mechanisms of action are not entirely clear...
  96. ncbi Ventilatory threshold is related to walking tolerance in patients with intermittent claudication
    M da Rocha Chehuen
    Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
    Vasa 41:275-81. 2012
    This study assessed the relationship between lower limb hemodynamics and metabolic parameters with walking tolerance in patients with intermittent claudication (IC).
  97. pmc Safety and efficacy of cilostazol in the management of intermittent claudication
    Yung Wei Chi
    Department of Cardiology, Section of Vascular Medicine, Ochsner Health System, 2005 Veterans Blvd, Metairie, LA 70002, USA
    Vasc Health Risk Manag 4:1197-203. 2008
    ..Many will suffer from intermittent claudication (IC), which leads to marked impairment of quality of life (QoL)...
  98. ncbi Plantar flexion as an alternative to treadmill exercise for evaluating patients with intermittent claudication
    K Yamamoto
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Eur J Vasc Endovasc Surg 33:325-9. 2007
    ..The aim of this study was to examine whether the plantar flexion test could adequately replace treadmill testing in patients who were unable to exercise...
  99. ncbi Long-term results of peripheral arterial disease rehabilitation
    Julie R Menard
    Department of Physical Education and Exercise Science, University of Rhode Island, Kingston, RI, USA
    J Vasc Surg 39:1186-92. 2004
    ..This study examined functional status, walking ability, and quality of life in patients several months after completion of a 12-week PADRx...
  100. pmc Calf muscle hemoglobin oxygen saturation characteristics and exercise performance in patients with intermittent claudication
    Andrew W Gardner
    CMRI Metabolic Research Program, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Vasc Surg 48:644-9. 2008
    This study was conducted to determine the association between the characteristics of calf muscle hemoglobin oxygen saturation (StO(2)) and exercise performance in patients with intermittent claudication.
  101. pmc Assessment of functional status and quality of life in claudication
    Ryan J Mays
    Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Vasc Surg 53:1410-21. 2011
    Treadmill walking is commonly used to evaluate walking impairment and efficacy of treatment for intermittent claudication (IC) in clinical and research settings...

Research Grants57

  1. Dietary Nitrate to Augment Exercise Training Benefits in DM+PAD
    Jason David Allen; Fiscal Year: 2013
    ..artery disease (PAD) affects 5% of the US population over 50 yrs, one third of which suffer from intermittent claudication (IC)...
  2. Genome-wide Association Study: Fetal Hemoglobin Phenotypes in Sickle Cell Disease
    Betty Pace; Fiscal Year: 2009
    ..and effective than traditional AER in clinical patients including those with peripheral artery disease, intermittent claudication, coronary artery disease, congestive heart failure, asthma, COPD, and the elderly (>75y)...
  3. Insulin Sensitivity using Aerobic Interval Conditioning (ISAIC)
    Conrad P Earnest; Fiscal Year: 2010
    ..and effective than traditional AER in clinical patients including those with peripheral artery disease, intermittent claudication, coronary artery disease, congestive heart failure, asthma, COPD, and the elderly (>75y)...
  4. Role of Femoral Atherosclerosis in Functional Status, CVD Events, and Mortality
    CHRISTINA LYNN WASSEL; Fiscal Year: 2013
    ..Furthermore, intermittent claudication, critical leg ischemia, and amputation resulting from PAD adversely affect quality of life and ..
  5. Role of Thromboxane in the Exercise Pressor Reflex in Peripheral Artery Disease
    ANNA KATHERINE LEAL; Fiscal Year: 2013
    ..Peripheral arterial disease leads to ischemia of the limbs and can cause intermittent claudication. It is possible that muscle metabolites, specifically prostaglandins, are partially responsible for the ..
  6. Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD
    Jason David Allen; Fiscal Year: 2013
    ..It affects 5% of the US population over 50 yrs, one third of which suffer from intermittent claudication (IC), defined as ischemic leg pain that occurs with walking and improves with rest...
  7. Pre-Clinical and Clinical Evaluation of Skeletal Muscle Activator, CK-2017357 for
    MALAR PANNIRSELVAM; Fiscal Year: 2012
    ..muscle weakness is a feature;these include serious neuromuscular disorders, rehabilitation recovery, intermittent claudication (cramping pains in the legs caused by peripheral arterial disease), muscle wasting (cachexia) associated ..
  8. The Effect of Aging and Vascular Occlusion on Gait Variability
    Sara A Myers; Fiscal Year: 2010
    ..Mobility problems in PAD patients are most commonly attributed to intermittent claudication, however, other manifestations of PAD could be contributing to the problem...
  9. Reuse of ZD4054 for patients with symptomatic PAD
    Brian H Annex; Fiscal Year: 2013
    ..b>Intermittent claudication (IC), defined as leg pain with walking that is relieved with rest, is the most frequent clinical ..
  10. Claudication Exercise vs Endoluminal Revascularization
    Donald Cutlip; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Intermittent claudication is common in older individuals and often substantially limits physical activity. Physical activity levels in the elderly strongly predict cardiovascular and other morbidity...
  11. Claudication: Exercise Vs. Endoluminal Revascularization
    Timothy P Murphy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Intermittent claudication is common in older individuals and often substantially limits physical activity. Physical activity levels in the elderly strongly predict cardiovascular and other morbidity...
  12. Cardiovascular Cell Therapy Research Network
    James T Willerson; Fiscal Year: 2013
    ..Finally, CCTR I overwhelmingly selected our bridging protocol (cell therapy in patients with intermittent claudication) to be implemented in the latter support period...
  13. Clinical Implications of Peripheral Plaque Morphology
    Daniel Clair; Fiscal Year: 2007
    ..placebo will be performed in patients with intermittent claudication, based on our hypothesis that statin therapy will result in stabilization or regression of femoral ..
  14. cGMP Phosphodiesterase Inhibitors in a Mouse Model of Duchenne Muscular Dystrophy
    STANLEY FROEHNER; Fiscal Year: 2009
    ..to be effective drug targets in treating several human diseases, including inflammatory airway diseases, intermittent claudication, recurrent stroke and erectile dysfunction...
  15. Polestriding versus Walking for PAD Rehabilitation
    Eileen Collins; Fiscal Year: 2009
    ..Patients with PAD of the lower extremities are subject to periods of intermittent claudication pain...
  16. Liposomal L-Carnitine
    HANS HOFLAND; Fiscal Year: 2002
    The goal of this proposal is to develop a new topical formulation for the treatment of intermittent claudication. Intermittent claudication is the primary symptom of peripheral arterial disease, and it affects over 4 million individuals ..
  17. EXERCISE FOR ELDERLY PERIPHERAL REVASCULARIZED PATIENTS
    Andrew Gardner; Fiscal Year: 2004
    ....
  18. Home-based vs. Supervised Exercise for Claudicants
    Andrew W Gardner; Fiscal Year: 2010
    Broad, Long-Term Objective. To make a significant impact in the clinical management of PAD patients with intermittent claudication by determining whether home-based exercise can be used to treat symptomatology. Rationale...
  19. SENSORY NEURONS WITH MODALITIES IDENTIFIED IN CULTURE
    EDWIN MC CLESKEY; Fiscal Year: 2006
    ..Ischemia is the primary source of cardiac pain, sickle cell anemia pain, and the muscle pain of intermittent claudication; it may also contribute to other forms of muscle, bone, and visceral pain...
  20. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..Although treadmill-walking exercise improves treadmill performance in patients with intermittent claudication (IC), treadmill performance does not correlate well with community walking ability in older men and ..
  21. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  22. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
  23. Reducing Risk Factors in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ....
  24. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  25. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
  26. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
    ..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
  27. HEALTH-RELATED QUALITY OF LIFE IN INTERMITTENT CLAUDICAT
    MARTHA MC DANIEL; Fiscal Year: 1991
    b>Intermittent claudication (IC), or pain in the lower extremities experienced and walking, is a common manifestation of atherosclerosis...
  28. Do acid-sensing ion channels trigger ischemic pain?
    HEATHER WENK; Fiscal Year: 2006
    ..Clinical examples include angina, intermittent claudication, and the intense pain accompanying sickle-cell anemia...
  29. Multifactor Risk Reduction for Optimal Management in Peripheral Arterial Disease
    Roberta K Oka; Fiscal Year: 2010
    ..This study will examine the effect of a system that assists providers to reduce a patient's CVD risk factors and explores the biological reasons that this system may be effective in improving health. ..
  30. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
    ..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
  31. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..End of Abstract) ..
  32. Peripheral Arterial Disease and Leg Muscle Metabolism
    LOIS KILLEWICH; Fiscal Year: 2005
    ..It is my ultimate hope that the combined interventions of bypass surgery and nutritional supplementation with amino acids can be used to improve overall functional status of these elderly Americans. ..
  33. Giant Cell Myocarditis Treatment Trial Pilot Study
    COOPER LESLIE; Fiscal Year: 2005
    ..Abstract Not Provided ..
  34. Inflammation and Immunity in Dilated Cardiomyopathy
    Leslie Cooper; Fiscal Year: 2004
    ..The long-term overall goal of this workshop is to translate advances in molecular and cellular mechanisms of disease into improvements in the diagnosis and treatment of patients with DCM. ..
  35. Inflammation and Insulin Resistance in PAD
    Mark Creager; Fiscal Year: 2007
    ..that inflammation and insulin resistance contribute to reduced walking distance in patients with intermittent claudication by impairing vascular reactivity and skeletal muscle metabolic function, plasma markers of inflammation ..
  36. Lipoproteins, HIV, and Antiretroviral Therapy in SMART
    Daniel Duprez; Fiscal Year: 2008
    ..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  37. HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTS
    SHARI WALDSTEIN; Fiscal Year: 2008
    ..abstract_text> ..
  38. Lifetime Risk of Cardiovascular Disease
    Donald Lloyd Jones; Fiscal Year: 2003
    ..abstract_text> ..
  39. Modulating Endothelialization of Cardiovascular Grafts
    Michael Sobel; Fiscal Year: 2008
    ..In an animal model of peripheral artery bypass grafting that closely resembles the human condition, we will test these constructs and cells for their ability to promote the growth of a stable endothelial lining. ..
  40. PLATELET/HEPARIN INTERACTIONS IN CARDIOVASCULAR SURGERY
    Michael Sobel; Fiscal Year: 2003
    ..abstract_text> ..
  41. MICROVASCULAR ENDOTHELIAL FUNCTION WITH MICROBUBBLES
    Jonathan Lindner; Fiscal Year: 2002
    ....
  42. REGIONAL BETA ADRENERGIC DURING LV REMODELING
    Christopher Kramer; Fiscal Year: 2002
    ..Effects of beta-blockade on regional cell morphometry, collagen content, and blood flow will be assessed using isolated myocytes, quantitative histopathology, and fluorescent microspheres, respectively. ..
  43. Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial Disease
    Kenneth Jay Mukamal; Fiscal Year: 2010
    ..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
  44. Heavy Drinking & Coronary Disease: Acute/Chronic Effects
    Kenneth Mukamal; Fiscal Year: 2006
    ..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
  45. Defining the Clinical Significance of HbA1c Prior to the Onset of Diabetes
    Elizabeth Selvin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  46. Epidemiologic Study of Ethnicity and Lifetime Risks for Cardiovascular Disease
    Donald Lloyd Jones; Fiscal Year: 2007
    ..This application represents a novel approach to analyzing existing data that is likely to yield substantial new insights into the epidemiology of CVD among non-white ethnic groups. [unreadable]..
  47. Epidemiology and Mechanisms of ECG Abnormalities: Young Adulthood to Middle Age
    Donald Lloyd Jones; Fiscal Year: 2009
    ....
  48. Osteoprotegerin and osteopontin in aortic aneurysm
    Jonathan Golledge; Fiscal Year: 2009
    ..Understanding the role of these calcium-controlling proteins in artery weakness and how drug therapy can interfere in these effects is an important step in the development of new treatment for aortic aneurysm. ..
  49. Comprehensive Magnetic Resonance in PAD
    Christopher Kramer; Fiscal Year: 2008
    ..Improving the health outcomes and quality of life in patients with PAD is a major goal of this proposal. ..
  50. Clinical Research Using Non-Fourier 3D Cardiac MRI
    Frank Rybicki; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Mechanism of Myocardial Angiogenesis in Transgenic/Knockout Animals
    Nilanjana Maulik; Fiscal Year: 2010
    ..This proposal will provide and will identify important new insights into the cellular and molecular mechanisms of the cardioprotection provided by VEGF signaling through important candidate genes. ..
  52. The Effect of Statins on Skeletal Muscle Function
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ....
  53. Contrast-enhanced Ultrasound Assessment of Angiogenesis
    Jonathan Lindner; Fiscal Year: 2007
    ..These studies will also validate the potential use of targeted contrast ultrasound for non-invasively evaluating new pro-angiogenic treatments and for guiding their use in patients. [unreadable] [unreadable]..
  54. PARASPINAL MUSCLE DENERVATION AND SYMPTOMS IN LUMBAR SS
    Andrew Haig; Fiscal Year: 2005
    ..Subjects will repeat the test battery (MRI, EMG, and clinical evaluation) approximately 18 months later. Appropriate statistics will test each of the four hypotheses. ..
  55. Paraspinal Denervation in Low Back Pain
    Andrew J Haig; Fiscal Year: 2010
    ..The results will help doctors avoid unnecessary surgery and help scientists to understand more about how spinal stenosis disables so many older people. ..