Genomes and Genes
Summary: A symptom complex characterized by leg pain and weakness brought on by walking, with the disappearance of the symptoms following a brief rest.
Publications313 found, 100 shown here
- Symptomatic peripheral arterial disease: the value of a validated questionnaire and a clinical decision ruleBianca Lw Bendermacher
Department of Surgery, Atrium Medical Centre, Heerlen, The Netherlands
Br J Gen Pract 56:932-7. 2006If a validated questionnaire, when applied to patients reporting with symptoms of intermittent claudication, could adequately discriminate between those with and without peripheral arterial disease, GPs could avoid the diagnostic ..
- Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)L Norgren
Department of Surgery, University Hospital, Orebro, Sweden
J Vasc Surg 45:S5-67. 2007
- Peripheral arterial disease detection, awareness, and treatment in primary careA T Hirsch
Vascular Medicine Program, Minnesota Vascular Diseases Center, Mayo Mail Code 508, University of Minnesota Medical School, 420 Delaware St, SE, Minneapolis, MN 55455, USA
JAMA 286:1317-24. 2001..Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis that is common and is associated with an increased risk of death and ischemic events, yet may be underdiagnosed in primary care practice...
- Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)L Norgren
Department of Surgery, University Hospital, Orebro, Sweden
Eur J Vasc Endovasc Surg 33:S1-75. 2007
- Femoral plaque echogenicity and cardiovascular risk in claudicantsVittorio Schiano
Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
JACC Cardiovasc Imaging 5:348-57. 2012..The present study was designed to verify whether the evaluation of femoral plaque echogenicity might be a useful tool for cardiovascular risk assessment in patients affected by lower extremity peripheral arterial disease...
- Medical treatment of peripheral arterial diseaseGraeme J Hankey
Department of Neurology, Royal Perth Hospital and School of Medicine and Pharmacology, University of Western Australia, Perth
JAMA 295:547-53. 2006..The goals of treatment are to prevent future major coronary and cerebrovascular events and improve leg symptoms...
- Interspinous implants (X Stop, Wallis, Diam) for the treatment of LSS: is there a correlation between radiological parameters and clinical outcome?Rolf Sobottke
Department of Orthopaedic and Trauma Surgery, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
Eur Spine J 18:1494-503. 2009Neurogenic intermittent claudication, caused by lumbar spinal stenosis (LSS), usually occurs after the age of 50 and is one of the most common degenerative spinal diseases in the elderly...
- A multicenter, prospective, randomized trial evaluating the X STOP interspinous process decompression system for the treatment of neurogenic intermittent claudication: two-year follow-up resultsJames F Zucherman
St Mary s Hospital, San Francisco, California, USA
Spine (Phila Pa 1976) 30:1351-8. 2005A randomized, controlled, prospective multicenter trial comparing the outcomes of neurogenic intermittent claudication (NIC) patients treated with the interspinous process decompression system (X STOP) with patients treated nonoperatively.
- X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-upBjörn H Strömqvist
Department of Orthopedics, Clinical Sciences Lund, Lund University, Skane University Hospital, Malmo, Sweden
Spine (Phila Pa 1976) 38:1436-42. 2013..Prospective randomized controlled study...
- Near-infrared spectroscopy assessment following exercise training in patients with intermittent claudication and in untrained healthy participantsFabio Manfredini
Vascular Diseases Center, University of Ferrara, Italy
Vasc Endovascular Surg 46:315-24. 2012..The assessment of NIRS parameters, that were found stable without training in healthy and modified in PAD only following structured training, might outline the local exercise-induced adaptations...
- A new pharmacological treatment for intermittent claudication: results of a randomized, multicenter trialH G Beebe
Jobst Vascular Center, Toledo, Ohio 43606, USA
Arch Intern Med 159:2041-50. 1999Effective medication is limited for the relief of intermittent claudication, a common manifestation of arterial occlusive disease. Cilostazol is a potent inhibitor of platelet aggregation with vasodilation effects.
- Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudicationAntonio Silvestro
Department of Medicine, University of Naples Federico II, Naples, Italy
Atherosclerosis 165:277-83. 2002In patients with intermittent claudication, exercise is associated with a marked increase in oxidative stress, likely responsible for systemic endothelial perturbation...
- Leg symptoms in peripheral arterial disease: associated clinical characteristics and functional impairmentM M McDermott
Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
JAMA 286:1599-606. 2001Persons with lower-extremity peripheral arterial disease (PAD) are often asymptomatic or have leg symptoms other than intermittent claudication (IC).
- The reliability of the Shuttle Walking Test, the Swiss Spinal Stenosis Questionnaire, the Oxford Spinal Stenosis Score, and the Oswestry Disability Index in the assessment of patients with lumbar spinal stenosisRoland K Pratt
Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom
Spine (Phila Pa 1976) 27:84-91. 2002....
- The effects of an interspinous implant on the kinematics of the instrumented and adjacent levels in the lumbar spineDerek P Lindsey
VA Rehab R and D Center, Palo Alto, CA, USA
Spine (Phila Pa 1976) 28:2192-7. 2003..Measurement of the kinematics of the lumbar spine after insertion of an interspinous spacer in vitro...
- Myeloscopic study on lumbar spinal canal stenosis with special reference to intermittent claudicationY Ooi
Jichi Medical School, Department of Orthopaedic Surgery, Kawachi gun, Tochigi, Japan
Spine (Phila Pa 1976) 15:544-9. 1990..canal stenosis were investigated by dynamic myeloscopy to explain the pathophysiologic mechanism of intermittent claudication, one of the characteristic signs of the disorder...
- Exercise-based interventions and health-related quality of life in intermittent claudication: a 20-year (1989-2008) reviewMarie Guidon
School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland
Eur J Cardiovasc Prev Rehabil 17:140-54. 2010..Symptoms include pain in leg muscles on walking, relieved by rest (intermittent claudication)...
- The treatment mechanism of an interspinous process implant for lumbar neurogenic intermittent claudicationJoshua C Richards
San Francisco Orthopaedic Residency Program, University of California, USA
Spine (Phila Pa 1976) 30:744-9. 2005..The spinal canal and neural foramina dimensions of cadaver lumbar spines were quantified during flexion and extension using magnetic resonance imaging before and after placement of an interspinous process implant...
- A systematic review to evaluate the effectiveness of carnitine supplementation in improving walking performance among individuals with intermittent claudicationChristopher L Delaney
Department of Vascular Surgery, Flinders University, Australia
Atherosclerosis 229:1-9. 2013To evaluate the evidence for the use of carnitine supplementation in improving walking performance among individuals with intermittent claudication.
- Multifactorial determinants of functional capacity in peripheral arterial disease: uncoupling of calf muscle perfusion and metabolismJustin D Anderson
Department of Medicine, University of Virginia Health System, University of Virginia, Charlottesville, VA 22908, USA
J Am Coll Cardiol 54:628-35. 2009..We aimed to investigate the pathophysiology of peripheral arterial disease (PAD) by examining magnetic resonance imaging (MRI) and spectroscopic (MRS) correlates of functional capacity...
- Efficacy of quantified home-based exercise and supervised exercise in patients with intermittent claudication: a randomized controlled trialAndrew W Gardner
CMRI Diabetes and Metabolic Research Program, Harold Hamm Oklahoma Diabetes Center, Oklahoma University Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK 73117, USA
Circulation 123:491-8. 2011..trial compared changes in exercise performance and daily ambulatory activity in peripheral artery disease patients with intermittent claudication after a home-based exercise program, a supervised exercise program, and usual-care control.
- Clinical evaluation of the preliminary safety and effectiveness of a minimally invasive interspinous process device APERIUS(®) in degenerative lumbar spinal stenosis with symptomatic neurogenic intermittent claudicationJan Van Meirhaeghe
Dienst Orthopedie en Traumatologie, AZ Sint Jan Brugge Oostende AV, Ruddershove 10, 8000 Brugge, Belgium
Eur Spine J 21:2565-72. 2012..provide an alternative to conservative treatment and decompressive surgery for patients with neurogenic intermittent claudication (NIC) due to degenerative lumbar spinal stenosis (DLSS)...
- The effect of exercise on haemodynamics in intermittent claudication: a systematic review of randomized controlled trialsBelinda J Parmenter
Exercise, Health and Performance Faculty Research Group, Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia
Sports Med 40:433-47. 2010..studies included randomized controlled trials using an exercise intervention for the treatment of intermittent claudication with haemodynamic measures of disease severity as outcomes...
- Randomized clinical trial of percutaneous transluminal angioplasty, supervised exercise and combined treatment for intermittent claudication due to femoropopliteal arterial diseaseF A K Mazari
Academic Vascular Surgical Unit, University of Hull, Hull, UK
Br J Surg 99:39-48. 2012The aim was to compare percutaneous transluminal angioplasty (PTA), a supervised exercise programme (SEP) and combined treatment (PTA plus SEP) for intermittent claudication due to femoropopliteal arterial disease.
- Corridor-based functional performance measures correlate better with physical activity during daily life than treadmill measures in persons with peripheral arterial diseaseMary M McDermott
Departments of Medicine and Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Vasc Surg 48:1231-7, 1237.e1. 2008..To compare associations of physical activity during daily life with treadmill walking performance and corridor-based functional performance measures in persons with lower extremity peripheral arterial disease (PAD)...
- Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudicationMark A Creager
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circulation 124:1765-73. 2011..intramuscular administration of Ad2/HIF-1α/VP16, an engineered recombinant type 2 adenovirus vector encoding constitutively active HIF-1α, improves walking time in patients with peripheral artery disease and intermittent claudication.
- Effectiveness of interspinous implant surgery in patients with intermittent neurogenic claudication: a systematic review and meta-analysisWouter A Moojen
Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
Eur Spine J 20:1596-606. 2011..The main objective of this review was to perform a meta-analysis of all systematic reviews, randomized clinical trials and prospective cohort series to quantify the effectiveness of IPDs and to evaluate the potential side-effects...
- The adjuvant benefit of angioplasty in patients with mild to moderate intermittent claudication (MIMIC) managed by supervised exercise, smoking cessation advice and best medical therapy: results from two randomised trials for stenotic femoropopliteal and R M Greenhalgh
Imperial College London, Vascular Surgery Research Group, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
Eur J Vasc Endovasc Surg 36:680-8. 2008Uncertainty exists on whether there is adjuvant benefit of percutaneous transluminal angioplasty (PTA) over supervised exercise and best medical therapy in the treatment of intermittent claudication.
- Limb-specific and cross-transfer effects of arm-crank exercise training in patients with symptomatic peripheral arterial diseaseGarry Tew
Centre for Sport and Exercise Science, Sheffield Hallam University, UK
Clin Sci (Lond) 117:405-13. 2009Arm cranking is a useful alternative exercise modality for improving walking performance in patients with intermittent claudication; however, the mechanisms of such an improvement are poorly understood...
- Asymptomatic peripheral arterial disease is associated with more adverse lower extremity characteristics than intermittent claudicationMary M McDermott
Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
Circulation 117:2484-91. 2008..This study assessed functional performance, calf muscle characteristics, peripheral nerve function, and quality of life in asymptomatic persons with peripheral arterial disease (PAD)...
- Quality of life in patients with intermittent claudication using the World Health Organisation (WHO) questionnaireJ C Breek
Department of Surgery, St. Elisabeth Hospital, Tilburg, The Netherlands
Eur J Vasc Endovasc Surg 21:118-22. 2001OBJECTIVE: to assess quality of life (QOL) in patients with intermittent claudication. DESIGN: a prospective, open study...
- Treating intermittent claudication with Tibetan medicine Padma 28: does it work?Jörg Melzer
Department of Internal Medicine, Complementary Medicine, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
Atherosclerosis 189:39-46. 2006..e. walking distance), probably of the same order of magnitude as other employed medications. However, larger confirmatory RCTs are desirable...
- Association of obesity and metabolic syndrome with the severity and outcome of intermittent claudicationJonathan Golledge
Vascular Biology Unit, James Cook University, Townsville, Queensland, Australia
J Vasc Surg 45:40-6. 2007..The aim of this study was to assess the association between obesity and the severity and outcome of intermittent claudication.
- Exercise therapy and the additional effect of supervision on exercise therapy in patients with intermittent claudication. Systematic review of randomised controlled trialsJ Wind
Tergooiziekenhuizen, location Hilversum, Department of Surgery, The Netherlands
Eur J Vasc Endovasc Surg 34:1-9. 2007To review the evidence for the effectiveness of exercise therapy and to estimate the additional effect of supervision on exercise therapy in patients with intermittent claudication.
- Translation and validation of the walking impairment questionnaire in Brazilian subjects with intermittent claudicationRaphael Mendes Ritti-Dias
Faculdade de Saude Publica, USP, Sao Paulo, SP, Brazil
Arq Bras Cardiol 92:136-49. 2009The Walking Impairment Questionnaire (WIQ) has been used to evaluate walking impairment in subjects with intermittent claudication (IC)...
- Peripheral arterial disease: comparison of color duplex US and contrast-enhanced MR angiography for diagnosisTim Leiner
Departments of Radiology, Clinical Epidemiology and Medical Technology Assessment, Epidemiology, and Vascular Surgery, Maastricht University Hospital, Peter Debijelaan 25, NL 6229 HX Maastricht, The Netherlands
Radiology 235:699-708. 2005....
- Multicenter randomized clinical trial of supervised exercise therapy with or without feedback versus walking advice for intermittent claudicationSaskia P A Nicolaï
Department of Surgery at Atrium Medical Center Parkstad, Heerlen, The Netherlands
J Vasc Surg 52:348-55. 2010The initial treatment for intermittent claudication is supervised exercise therapy (SET). Owing to limited capacity and patient transports costs of clinic-based SET, a concept of SET provided by local physiotherapists was developed...
- The effects of including quality of life responses in models to predict walking performance of patients with intermittent claudicationA S Leicht
Institute of Sport and Exercise Science, James Cook University, Townsville, Queensland 4811, Australia
Eur J Vasc Endovasc Surg 41:511-7. 2011..the accuracy of previously developed prediction models of treadmill walking performance in patients with intermittent claudication (IC) due to peripheral arterial disease (PAD); and to examine the accuracy of new prediction models.
- When is supervised exercise therapy considered useful in peripheral arterial occlusive disease? A nationwide survey among vascular surgeonsG J Lauret
Department of Vascular Surgery, Catharina Hospital, Eindhoven, The Netherlands
Eur J Vasc Endovasc Surg 43:308-12. 2012..guidelines state that supervised exercise therapy (SET) should be offered to all patients with intermittent claudication (IC), SET appears to be underutilised in clinical practice...
- Two-year results of interspinous spacer (X-Stop) implantation in 175 patients with neurologic intermittent claudication due to lumbar spinal stenosisJohannes Kuchta
Department of Neurosurgery, MediaParc Clinic, Cologne, Germany
Eur Spine J 18:823-9. 2009..The X-Stop is the most commonly used interspinous distraction device in patients with neurogenic intermittent claudication due to LSS...
- Insertion loads of the X STOP interspinous process distraction system designed to treat neurogenic intermittent claudicationVikram Talwar
San Francisco Orthopaedic Residency Program, CA, USA
Eur Spine J 15:908-12. 2006An interspinous process implant has been developed to treat patients suffering from neurogenic intermittent claudication secondary to lumbar spinal stenosis...
- Detection of peripheral vascular stenosis by assessing skeletal muscle flow reserveThanjuvar Bragadeesh
Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, Virginia
J Am Coll Cardiol 45:780-5. 2005..We sought to determine whether the severity of peripheral arterial disease (PAD) can be assessed by measuring blood flow reserve in limb skeletal muscle with contrast-enhanced ultrasound (CEU)...
- Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular StudyA St-Pierre
Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec City, Canada
Can J Cardiol 26:17-21. 2010The natural history of intermittent claudication, from its risk factors to its cardiovascular prognosis, has been reported in few prospective studies.
- Exercise training for claudicationKerry J Stewart
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
N Engl J Med 347:1941-51. 2002
- Magnetic resonance imaging in peripheral arterial disease: reproducibility of the assessment of morphological and functional vascular statusBas Versluis
Department of Radiology, Maastricht University Medical Center MUMC, Maastricht, The Netherlands
Invest Radiol 46:11-24. 2011....
- Effects of cilostazol on resting ankle pressures and exercise-induced ischemia in patients with intermittent claudicationE R Mohler
University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Vasc Med 6:151-6. 2001During exercise, patients with intermittent claudication (IC) have decreased limb arterial blood pressure that recovers during rest...
- Postoperative outcomes for patients undergoing elective revascularization for critical limb ischemia and intermittent claudication: a subanalysis of the Coronary Artery Revascularization Prophylaxis (CARP) trialAmritha Raghunathan
Vascular Surgery Service, San Francisco VA Medical Center and Univ of California at San Francisco, CA 94121, USA
J Vasc Surg 43:1175-82. 2006..rate, and long-term survival of patients with critical limb ischemia (CLI) compared with those with intermittent claudication (IC) within a cohort selected for significant coronary artery disease, a secondary analysis was ..
- Intermittent claudication: an overviewAshwinkumar V Meru
New Drug Discovery Research, Department of Pharmacology, Ranbaxy Laboratories Limited, R and D, Plot 20, Sector 18, Udyog Vihar Industrial Area, Gurgaon 122001, Haryana, India
Atherosclerosis 187:221-37. 2006b>Intermittent claudication (IC) is defined by leg muscle pain, cramping and fatigue brought on by ambulation/exercise; relieved on rest; and caused by inadequate blood supply and is the primary symptom of peripheral arterial disease (PAD)...
- Strength training increases walking tolerance in intermittent claudication patients: randomized trialRaphael Mendes Ritti-Dias
School of Physical Education, University of Pernambuco, Pernambuco, Brazil
J Vasc Surg 51:89-95. 2010To analyze the effects of strength training (ST) in walking capacity in patients with intermittent claudication (IC) compared with walking training (WT) effects.
- Gender differences in daily ambulatory activity patterns in patients with intermittent claudicationAndrew W Gardner
CMRI Diabetes and Metabolic Research Program, Harold Hamm Oklahoma Diabetes Center, Oklahoma University Health Sciences Center OUHSC, Department of Boistatistics and Epidemiology, Oklahoma City, OK 73117, USA
J Vasc Surg 52:1204-10. 2010To compare the pattern of daily ambulatory activity in men and women with intermittent claudication, and to determine whether calf muscle hemoglobin oxygen saturation (StO2) is associated with daily ambulatory activity.
- A pooled analysis of the durability and predictors of treatment response of cilostazol in patients with intermittent claudicationReena L Pande
Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Vasc Med 15:181-8. 2010Pharmacologic therapy for intermittent claudication in patients with peripheral artery disease (PAD) is limited...
- Cilostazol has beneficial effects in treatment of intermittent claudication: results from a multicenter, randomized, prospective, double-blind trialD L Dawson
Department of Surgery, University of Washington, Seattle, USA
Circulation 98:678-86. 1998..This prospective, randomized, placebo-controlled, parallel-group clinical trial evaluated the efficacy of cilostazol for treatment of stable, moderately severe intermittent claudication.
- Effective training for patients with intermittent claudicationStig A Slørdahl
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Scand Cardiovasc J 39:244-9. 2005Current guidelines for treatment of intermittent claudication (IC) do not include a specific recommendation for the intensity of exercise therapy...
- Reduction of remnant lipoprotein cholesterol concentrations by cilostazol in patients with intermittent claudicationTao Wang
Otsuka America Pharmaceutical Inc, Rockville, MD, USA
Atherosclerosis 171:337-42. 2003..lipoproteins and reduced high-density lipoproteins (HDL) are associated with the development of intermittent claudication (IC), a life-limiting symptom of peripheral arterial disease...
- Relationship between temporal-spatial gait parameters, gait kinematics, walking performance, exercise capacity, and physical activity level in peripheral arterial diseaseRobert G Crowther
Institute of Sport and Exercise Science, James Cook University, Townsville Hospital, Queensland, Australia
J Vasc Surg 45:1172-8. 2007..function is a feature of patients with peripheral arterial disease (PAD) who present with symptoms of intermittent claudication (PAD-IC)...
- Cost-effectiveness targets for multi-detector row CT angiography in the work-up of patients with intermittent claudicationKaren Visser
Program for the Assessment of Radiological Technology, Department of Epidemiology and Biostatistics, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, Rm Ee21 40B, 3015GE Rotterdam, The Netherlands
Radiology 227:647-56. 2003..multi-detector row computed tomographic (CT) angiography results in the work-up of patients with intermittent claudication that would make this imaging examination cost-effective compared with gadolinium-enhanced magnetic ..
- [Antiischemic efficacy of trimetazidine in patients with intermittent claudication and effort angina]A L Syrkin
Moskovskaia meditsinskaia akademiia im I M Sechenova, Moskva
Kardiologiia 43:49-52. 2003..Statistically significant decreases of frequency of attacks of angina, nitroglycerine consumption and increases of walking distance occurred only in group 1...
- Improvement of the walking ability in intermittent claudication due to superficial femoral artery occlusion with supervised exercise and pneumatic foot and calf compression: a randomised controlled trialS K Kakkos
Vascular Unit, Ealing Hospital, Southall, Middlesex, UK
Eur J Vasc Endovasc Surg 30:164-75. 2005..of unsupervised exercise, supervised exercise and intermittent pneumatic foot and calf compression (IPC) on the claudication distance, lower limb arterial haemodynamics and quality of life of patients with intermittent claudication.
- Percutaneous angioplasty of the superior gluteal artery for buttock claudication: a report of seven cases and literature reviewMichel Batt
Department of Vascular Surgery, Hopital Saint Roch, Nice, France
J Vasc Surg 43:987-91. 2006....
- Cilostazol: treatment of intermittent claudicationM P Reilly
Cardiovascular Division, Department of Medicine, School of Medicine, University of Pennsylvania, 432 PHI Bldg, 51 North 39th St, Philadelphia, PA 19104-2699, USA
Ann Pharmacother 35:48-56. 2001..and clinical utility of cilostazol, an antiplatelet and vasodilator agent approved for the management of intermittent claudication. DATA SOURCES: Primary literature on cilostazol was identified from a comprehensive MEDLINE literature ..
- Reliability of treadmill testing in peripheral arterial disease: a meta-regression analysisSaskia P A Nicolaï
Department of Surgery, Atrium Medical Center Parkstad, Heerlen, The Netherlands
J Vasc Surg 50:322-9. 2009..A meta-regression analysis was conducted to identify the most reliable treadmill protocol for the assessment of patients with peripheral arterial disease (PAD)...
- β-Blockers in patients with intermittent claudication and arterial hypertension: results from the nebivolol or metoprolol in arterial occlusive disease trialChristine Espinola-Klein
Department of Medicine II, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
Hypertension 58:148-54. 2011..A total of 128 patients with intermittent claudication and essential hypertension were included and double-blind randomized to receive 5 mg of nebivolol (N=65) ..
- Nordic poles immediately improve walking distance in patients with intermittent claudicationC Oakley
Centre for Sport and Exercise Science, Sheffield Hallam University, Collegiate Crescent Campus, Sheffield, S10 2BP, UK
Eur J Vasc Endovasc Surg 36:689-94; discussion 695-6. 2008To investigate the immediate effects of Nordic pole walking (NPW) on walking distance and cardiopulmonary workload in patients with intermittent claudication.
- Results for primary bypass versus primary angioplasty/stent for intermittent claudication due to superficial femoral artery occlusive diseaseJeffrey J Siracuse
Division of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02210, USA
J Vasc Surg 55:1001-7. 2012..However, long-term results comparing these modalities for primary intervention in patients who have had no prior intervention have not been reported. We report our results with 3-year follow-up...
- Secondhand smoke exposure and intermittent claudication: a Scotland-wide study of 4231 non-smokersLiya Lu
Department of Public Health, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
Heart 99:1342-5. 2013..In contrast, published evidence on the association with secondhand smoke (SHS) is very limited. The aim of this study was to examine the association between SHS exposure and intermittent claudication (IC) among middle aged non-smokers.
- Intermittent claudication: clinical effectiveness of endovascular revascularization versus supervised hospital-based exercise training--randomized controlled trialSandra Spronk
Department of Surgery, Vascular Laboratory, Ikazia Hospital, Rotterdam, The Netherlands
Radiology 250:586-95. 2009To compare clinical success, functional capacity, and quality of life during 12 months after revascularization or supervised exercise training in patients with intermittent claudication.
- Gait variability of patients with intermittent claudication is similar before and after the onset of claudication painSara A Myers
Nebraska Biomechanics Core Facility, University of Nebraska at Omaha, Omaha, NE 68182 0216, USA
Clin Biomech (Bristol, Avon) 26:729-34. 2011Recent research demonstrated that intermittent claudication patients have increased gait variability prior to the onset of claudication...
- Treadmill test is limited in elderly patients with peripheral arterial diseaseN Wolosker
School of Physical Education, University of Pernambuco, Santo Amaro, BR Recife, Brazil
Vasa 39:237-41. 2010..To describe the applicability and the performance of the treadmill test in elderly patients with peripheral arterial disease (PAD) and without PAD (non-PAD)...
- Effects of policosanol and ticlopidine in patients with intermittent claudication: a double-blinded pilot comparative studyGladys Castaño
Medical Surgical Research Center, Havana City, Cuba
Angiology 55:361-71. 2004..was undertaken to compare the effects of policosanol and ticlopidine in patients with moderately severe intermittent claudication (IC)...
- Cystic adventitial disease: a case report and literature reviewArvind Vasudevan
Department of Vascular Surgery, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
ANZ J Surg 75:1120-2. 2005..A literature review revealed the different theories for pathogenesis, the investigation of choice being catheter angiography and the treatment excision with bypass grafting...
- Late effects of a brief psychological intervention in patients with intermittent claudication in a randomized clinical trialM A Cunningham
Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia
Br J Surg 100:756-60. 2013..results of a trial of a brief psychological intervention to increase physical activity in patients with intermittent claudication. After 4 months, participants in the intervention group walked a mean of 1576 more steps per day than ..
- Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trialAnna A Ahimastos
Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Rd Central, Melbourne, Victoria, 8008 Australia
JAMA 309:453-60. 2013Approximately one-third of patients with peripheral artery disease experience intermittent claudication, with consequent loss of quality of life.
- Prediction of intermittent claudication, ischemic stroke, and other cardiovascular disease by detection of abdominal aortic calcific deposits by plain lumbar radiographsYamini S Levitzky
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
Am J Cardiol 101:326-31. 2008..to vascular calcium testing for generalized assessment of cardiovascular disease (CVD) outcomes, such as intermittent claudication (IC) and ischemic stroke (IS)...
- Pain threshold is achieved at intensity above anaerobic threshold in patients with intermittent claudicationRaphael Mendes Ritti-Dias
Department of Nutrition, School of Public Health, Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
J Cardiopulm Rehabil Prev 29:396-401. 2009..training is considered as the first treatment option for patients with peripheral arterial disease and intermittent claudication (IC)...
- Incidence and management of intermittent claudication in primary care in The NetherlandsWouter T Meijer
Department of General Practice, Erasmus Medical Center Rotterdam, The Netherlands
Scand J Prim Health Care 20:33-4. 2002To study the incidence and management of intermittent claudication in primary care.
- Estimation of the functional role of arterial pathways to the buttock circulation during treadmill walking in patients with claudicationVincent Jaquinandi
Physiologie, Explorations Fonctionnelles Vasculaires et d Effort and Laboratoire de Physiologie, UMR Centre National de la Recherche Scientifique 6214, Institut National de la Santé de la Recherche Médicale 771, 49933 Angers Cedex 9, France
J Appl Physiol 102:1105-12. 2007..Distal Ptc(O(2)) decrease at exercise aggravates proximal Ptc(O(2)) decrease, possibly through the occurrence of a "steal phenomenon" of distal over proximal circulation during walking...
- Neurogenic intermittent claudication in lumbar spinal canal stenosis: the clinical relationship between the local pressure of the intervertebral foramen and the clinical findings in lumbar spinal canal stenosisYuichiro Morishita
Department of Orthopaedic Surgery, Fukuoka University, Jyonan ku, Fukuoka, Japan
J Spinal Disord Tech 22:130-4. 2009..The clinical relationship between the local pressure of the intervertebral foramen and the clinical findings in lumbar spinal canal stenosis were evaluated...
- Natural history of physical function in older men with intermittent claudicationAndrew W Gardner
Department of Health and Sport Sciences, University of Oklahoma, Norman 73019, USA
J Vasc Surg 40:73-8. 2004This study was undertaken to determine the natural history of physical function in older men limited by intermittent claudication.
- Beneficial effects of exercise beyond the pain threshold in intermittent claudicationRoberto Carlon
Cardiovascular Department, Cittadella Hospital, Azienda ASSL 15 Alta Padovana, Cittadella, PD, Italy
Ital Heart J 4:113-20. 2003The quality of life and autonomy may be severely hampered in patients with intermittent claudication, but the amputation rate is very low. Supervised exercise training is effective, but still very rarely employed...
- Percutaneous transluminal angioplasty of infrapopliteal arteries in patients with intermittent claudication: acute and one-year resultsHans Krankenberg
Center for Cardiology and Vascular Intervention, Hamburg, Germany
Catheter Cardiovasc Interv 64:12-7. 2005..In contrast, PTA is currently not the therapy of choice in intermittent claudication (IC). In this prospective study, patients with IC were treated percutaneously...
- Successful lower extremity angioplasty improves brachial artery flow-mediated dilation in patients with peripheral arterial diseaseMarc Husmann
Cardiovascular Department, Division of Clinical and Interventional Angiology, University Hospital Berne and University of Berne, Berne, Switzerland
J Vasc Surg 48:1211-6. 2008..We assumed that endovascular revascularization of lower limb arterial obstructions ameliorates FMD and lowers inflammation through improvement of peripheral perfusion...
- Interobserver variability of ankle-brachial index measurements at rest and post exercise in patients with intermittent claudicationHerman van Langen
Vascular Laboratory, VieCuri Medical Centre, Venlo, The Netherlands
Vasc Med 14:221-6. 2009..index (ABI) post exercise is claimed to play a complementary role in the diagnosis or exclusion of intermittent claudication (IC)...
- Efficacy and safety of cilostazol, a novel phosphodiesterase inhibitor in patients with intermittent claudicationShivpreet S Samra
St George s Hospital, Mumbai 400001
J Indian Med Assoc 101:561-2, 564. 2003Pharmacotherapy is limited for the relief of intermittent claudication (IC), a common manifestation of peripheral arterial disease (PAD)...
- Walking exercise in patients with intermittent claudication. Experience in routine clinical practiceMarie Louise Bartelink
University Medical Centre Utrecht, Julius Center for Health Sciences and Primary Care Utrecht, The Netherlands
Br J Gen Pract 54:196-200. 2004In patients with intermittent claudication, exercise in the form of walking is effective in reducing pain and maximising achievable walking distance. However, data are lacking on the implementation of walking exercise in these patients.
- An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal diseaseFayyaz Ali Khan Mazari
Academic Vascular Surgical Unit, University of Hull, Vascular Laboratory, Alderson House, Hull Royal Infirmary, Hull, United Kingdom
J Vasc Surg 52:77-84. 2010..To establish the relationship between quality of life (QOL) index scores and clinical indicators of lower limb ischemia...
- Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise trainingW Schuyler Jones
Division of Cardiology, Duke University Medical Center, Durham, NC, USA
Vasc Med 17:94-100. 2012..These somewhat unexpected findings suggest that further investigation into the mechanism of vascular responses to exercise training in PAD patients is warranted...
- Physical training for intermittent claudication: a comparison of structured rehabilitation versus home-based trainingSteve Degischer
Department of Angiology, University of Basel Medical School, Switzerland
Vasc Med 7:109-15. 2002..0-385.7 m], for ACD and ICD, respectively. Structured, supervised PAD rehabilitation is a highly efficacious treatment for intermittent claudication and may be regarded as the present gold standard among conservative treatment options.
- Drug therapy for improving walking distance in intermittent claudication: a systematic review and meta-analysis of robust randomised controlled studiesA H Momsen
Department of Surgery, Regional Hospital Herning, Denmark
Eur J Vasc Endovasc Surg 38:463-74. 2009..interventions in improving walking capacity and health-related quality of life for people with intermittent claudication. DATASOURCES: We searched Medline, EMBASE, Cochrane library and relevant websites for studies published ..
- Blood pressure in patients with intermittent claudication increases continuously during walkingE F Bakke
Department of Vascular Diagnosis and Research, Oslo Vascular Centre, Aker University Hospital, University of Oslo, Oslo, Norway
Eur J Vasc Endovasc Surg 33:20-5. 2007..The purpose of this study was to compare the circulatory responses to walking in patients with peripheral atherosclerotic disease (PAD) and healthy controls...
- Effects of supervised treadmill walking training on calf muscle capillarization in patients with intermittent claudicationJianxiong Wang
Department of Exercise Science and Sport Management, Southern Cross University, Lismore, Australia
Angiology 60:36-41. 2009..the effects of supervised treadmill walking training on the calf muscle capillarization in patients with intermittent claudication. The first 12-week period was a non-exercise, within-subject control stage, and the second 12-week ..
- Supervised exercise therapy for intermittent claudication: current status and future perspectivesGert Jan Lauret
Department of Vascular Surgery, Catharina Hospital, PO Box 1350, 5602 ZA, Eindhoven
Vascular 20:12-9. 2012b>Intermittent claudication (IC) has a high prevalence in the older population and is closely associated with cardiovascular and cerebrovascular disease. High mortality rates are reported due to ongoing atherosclerotic disease...
- Supervised walking therapy in patients with intermittent claudicationFarzin Fakhry
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
J Vasc Surg 56:1132-42. 2012Exercise therapy is a common intervention for the management of intermittent claudication (IC)...
- The outback catheter: a new device for true lumen re-entry after dissection during recanalization of arterial occlusionsKlaus A Hausegger
Department of Radiology, University Hospital Graz, Auenbruggerplatz 9, 8036 Graz, Austria
Cardiovasc Intervent Radiol 27:26-30. 2004....
- Medical management of peripheral arterial disease: a therapeutic algorithmAlan B Lumsden
Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
J Endovasc Ther 13:II19-29. 2006..The most common symptom of mild-to-moderate PAD is intermittent claudication, present in about one third of symptomatic patients...
- Inhibition of adenosine uptake and augmentation of ischemia-induced increase of interstitial adenosine by cilostazol, an agent to treat intermittent claudicationY Liu
Maryland Research Laboratories, Otsuka America Pharmaceutical Inc, Rockville 20850, USA
J Cardiovasc Pharmacol 36:351-60. 2000..activity, was recently approved by the Food and Drug Administration for treatment of symptoms of intermittent claudication (IC). However, the underlying mechanisms of action are not entirely clear...
- Ventilatory threshold is related to walking tolerance in patients with intermittent claudicationM da Rocha Chehuen
Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
Vasa 41:275-81. 2012This study assessed the relationship between lower limb hemodynamics and metabolic parameters with walking tolerance in patients with intermittent claudication (IC).
- Safety and efficacy of cilostazol in the management of intermittent claudicationYung Wei Chi
Department of Cardiology, Section of Vascular Medicine, Ochsner Health System, 2005 Veterans Blvd, Metairie, LA 70002, USA
Vasc Health Risk Manag 4:1197-203. 2008..Many will suffer from intermittent claudication (IC), which leads to marked impairment of quality of life (QoL)...
- Plantar flexion as an alternative to treadmill exercise for evaluating patients with intermittent claudicationK Yamamoto
Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Eur J Vasc Endovasc Surg 33:325-9. 2007..The aim of this study was to examine whether the plantar flexion test could adequately replace treadmill testing in patients who were unable to exercise...
- Long-term results of peripheral arterial disease rehabilitationJulie R Menard
Department of Physical Education and Exercise Science, University of Rhode Island, Kingston, RI, USA
J Vasc Surg 39:1186-92. 2004..This study examined functional status, walking ability, and quality of life in patients several months after completion of a 12-week PADRx...
- Calf muscle hemoglobin oxygen saturation characteristics and exercise performance in patients with intermittent claudicationAndrew W Gardner
CMRI Metabolic Research Program, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
J Vasc Surg 48:644-9. 2008This study was conducted to determine the association between the characteristics of calf muscle hemoglobin oxygen saturation (StO(2)) and exercise performance in patients with intermittent claudication.
- Assessment of functional status and quality of life in claudicationRyan J Mays
Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA
J Vasc Surg 53:1410-21. 2011Treadmill walking is commonly used to evaluate walking impairment and efficacy of treatment for intermittent claudication (IC) in clinical and research settings...
- Dietary Nitrate to Augment Exercise Training Benefits in DM+PADJason David Allen; Fiscal Year: 2013..artery disease (PAD) affects 5% of the US population over 50 yrs, one third of which suffer from intermittent claudication (IC)...
- Genome-wide Association Study: Fetal Hemoglobin Phenotypes in Sickle Cell DiseaseBetty Pace; Fiscal Year: 2009..and effective than traditional AER in clinical patients including those with peripheral artery disease, intermittent claudication, coronary artery disease, congestive heart failure, asthma, COPD, and the elderly (>75y)...
- Insulin Sensitivity using Aerobic Interval Conditioning (ISAIC)Conrad P Earnest; Fiscal Year: 2010..and effective than traditional AER in clinical patients including those with peripheral artery disease, intermittent claudication, coronary artery disease, congestive heart failure, asthma, COPD, and the elderly (>75y)...
- Role of Femoral Atherosclerosis in Functional Status, CVD Events, and MortalityCHRISTINA LYNN WASSEL; Fiscal Year: 2013..Furthermore, intermittent claudication, critical leg ischemia, and amputation resulting from PAD adversely affect quality of life and ..
- Role of Thromboxane in the Exercise Pressor Reflex in Peripheral Artery DiseaseANNA KATHERINE LEAL; Fiscal Year: 2013..Peripheral arterial disease leads to ischemia of the limbs and can cause intermittent claudication. It is possible that muscle metabolites, specifically prostaglandins, are partially responsible for the ..
- Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PADJason David Allen; Fiscal Year: 2013..It affects 5% of the US population over 50 yrs, one third of which suffer from intermittent claudication (IC), defined as ischemic leg pain that occurs with walking and improves with rest...
- Pre-Clinical and Clinical Evaluation of Skeletal Muscle Activator, CK-2017357 forMALAR PANNIRSELVAM; Fiscal Year: 2012..muscle weakness is a feature;these include serious neuromuscular disorders, rehabilitation recovery, intermittent claudication (cramping pains in the legs caused by peripheral arterial disease), muscle wasting (cachexia) associated ..
- The Effect of Aging and Vascular Occlusion on Gait VariabilitySara A Myers; Fiscal Year: 2010..Mobility problems in PAD patients are most commonly attributed to intermittent claudication, however, other manifestations of PAD could be contributing to the problem...
- Reuse of ZD4054 for patients with symptomatic PADBrian H Annex; Fiscal Year: 2013..b>Intermittent claudication (IC), defined as leg pain with walking that is relieved with rest, is the most frequent clinical ..
- Claudication Exercise vs Endoluminal RevascularizationDonald Cutlip; Fiscal Year: 2012DESCRIPTION (provided by applicant): Intermittent claudication is common in older individuals and often substantially limits physical activity. Physical activity levels in the elderly strongly predict cardiovascular and other morbidity...
- Claudication: Exercise Vs. Endoluminal RevascularizationTimothy P Murphy; Fiscal Year: 2012DESCRIPTION (provided by applicant): Intermittent claudication is common in older individuals and often substantially limits physical activity. Physical activity levels in the elderly strongly predict cardiovascular and other morbidity...
- Cardiovascular Cell Therapy Research NetworkJames T Willerson; Fiscal Year: 2013..Finally, CCTR I overwhelmingly selected our bridging protocol (cell therapy in patients with intermittent claudication) to be implemented in the latter support period...
- Clinical Implications of Peripheral Plaque MorphologyDaniel Clair; Fiscal Year: 2007..placebo will be performed in patients with intermittent claudication, based on our hypothesis that statin therapy will result in stabilization or regression of femoral ..
- cGMP Phosphodiesterase Inhibitors in a Mouse Model of Duchenne Muscular DystrophySTANLEY FROEHNER; Fiscal Year: 2009..to be effective drug targets in treating several human diseases, including inflammatory airway diseases, intermittent claudication, recurrent stroke and erectile dysfunction...
- Polestriding versus Walking for PAD RehabilitationEileen Collins; Fiscal Year: 2009..Patients with PAD of the lower extremities are subject to periods of intermittent claudication pain...
- Liposomal L-CarnitineHANS HOFLAND; Fiscal Year: 2002The goal of this proposal is to develop a new topical formulation for the treatment of intermittent claudication. Intermittent claudication is the primary symptom of peripheral arterial disease, and it affects over 4 million individuals ..
- EXERCISE FOR ELDERLY PERIPHERAL REVASCULARIZED PATIENTSAndrew Gardner; Fiscal Year: 2004....
- Home-based vs. Supervised Exercise for ClaudicantsAndrew W Gardner; Fiscal Year: 2010Broad, Long-Term Objective. To make a significant impact in the clinical management of PAD patients with intermittent claudication by determining whether home-based exercise can be used to treat symptomatology. Rationale...
- SENSORY NEURONS WITH MODALITIES IDENTIFIED IN CULTUREEDWIN MC CLESKEY; Fiscal Year: 2006..Ischemia is the primary source of cardiac pain, sickle cell anemia pain, and the muscle pain of intermittent claudication; it may also contribute to other forms of muscle, bone, and visceral pain...
- Improving Functioning in Peripheral Arterial DiseaseMary McDermott; Fiscal Year: 2007..Although treadmill-walking exercise improves treadmill performance in patients with intermittent claudication (IC), treadmill performance does not correlate well with community walking ability in older men and ..
- BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMESMary McDermott; Fiscal Year: 2004....
- Magnetic Resonance in Peripheral Arterial DiseaseMary Mcgrae McDermott; Fiscal Year: 2010..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
- Reducing Risk Factors in Peripheral Arterial DiseaseMary Mcgrae McDermott; Fiscal Year: 2010....
- Mechanisms of Disability in Peripheral Arterial DiseaseMary McDermott; Fiscal Year: 2005..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
- PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMESMary McDermott; Fiscal Year: 2001..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
- Inflammation and Peripheral Arterial Disease OutcomesMary McDermott; Fiscal Year: 2008..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
- HEALTH-RELATED QUALITY OF LIFE IN INTERMITTENT CLAUDICATMARTHA MC DANIEL; Fiscal Year: 1991b>Intermittent claudication (IC), or pain in the lower extremities experienced and walking, is a common manifestation of atherosclerosis...
- Do acid-sensing ion channels trigger ischemic pain?HEATHER WENK; Fiscal Year: 2006..Clinical examples include angina, intermittent claudication, and the intense pain accompanying sickle-cell anemia...
- Multifactor Risk Reduction for Optimal Management in Peripheral Arterial DiseaseRoberta K Oka; Fiscal Year: 2010..This study will examine the effect of a system that assists providers to reduce a patient's CVD risk factors and explores the biological reasons that this system may be effective in improving health. ..
- CARDIAC VALVE CALCIFICATIONEmile Mohler; Fiscal Year: 2003..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
- Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A SubsMark A Creager; Fiscal Year: 2010..End of Abstract) ..
- Peripheral Arterial Disease and Leg Muscle MetabolismLOIS KILLEWICH; Fiscal Year: 2005..It is my ultimate hope that the combined interventions of bypass surgery and nutritional supplementation with amino acids can be used to improve overall functional status of these elderly Americans. ..
- Giant Cell Myocarditis Treatment Trial Pilot StudyCOOPER LESLIE; Fiscal Year: 2005..Abstract Not Provided ..
- Inflammation and Immunity in Dilated CardiomyopathyLeslie Cooper; Fiscal Year: 2004..The long-term overall goal of this workshop is to translate advances in molecular and cellular mechanisms of disease into improvements in the diagnosis and treatment of patients with DCM. ..
- Inflammation and Insulin Resistance in PADMark Creager; Fiscal Year: 2007..that inflammation and insulin resistance contribute to reduced walking distance in patients with intermittent claudication by impairing vascular reactivity and skeletal muscle metabolic function, plasma markers of inflammation ..
- Lipoproteins, HIV, and Antiretroviral Therapy in SMARTDaniel Duprez; Fiscal Year: 2008..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
- HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTSSHARI WALDSTEIN; Fiscal Year: 2008..abstract_text> ..
- Lifetime Risk of Cardiovascular DiseaseDonald Lloyd Jones; Fiscal Year: 2003..abstract_text> ..
- Modulating Endothelialization of Cardiovascular GraftsMichael Sobel; Fiscal Year: 2008..In an animal model of peripheral artery bypass grafting that closely resembles the human condition, we will test these constructs and cells for their ability to promote the growth of a stable endothelial lining. ..
- PLATELET/HEPARIN INTERACTIONS IN CARDIOVASCULAR SURGERYMichael Sobel; Fiscal Year: 2003..abstract_text> ..
- MICROVASCULAR ENDOTHELIAL FUNCTION WITH MICROBUBBLESJonathan Lindner; Fiscal Year: 2002....
- REGIONAL BETA ADRENERGIC DURING LV REMODELINGChristopher Kramer; Fiscal Year: 2002..Effects of beta-blockade on regional cell morphometry, collagen content, and blood flow will be assessed using isolated myocytes, quantitative histopathology, and fluorescent microspheres, respectively. ..
- Endothelial Dysfunction, Oxidative Stress and Risk of Peripheral Arterial DiseaseKenneth Jay Mukamal; Fiscal Year: 2010..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..
- Heavy Drinking & Coronary Disease: Acute/Chronic EffectsKenneth Mukamal; Fiscal Year: 2006..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..
- Defining the Clinical Significance of HbA1c Prior to the Onset of DiabetesElizabeth Selvin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Epidemiologic Study of Ethnicity and Lifetime Risks for Cardiovascular DiseaseDonald Lloyd Jones; Fiscal Year: 2007..This application represents a novel approach to analyzing existing data that is likely to yield substantial new insights into the epidemiology of CVD among non-white ethnic groups. [unreadable]..
- Epidemiology and Mechanisms of ECG Abnormalities: Young Adulthood to Middle AgeDonald Lloyd Jones; Fiscal Year: 2009....
- Osteoprotegerin and osteopontin in aortic aneurysmJonathan Golledge; Fiscal Year: 2009..Understanding the role of these calcium-controlling proteins in artery weakness and how drug therapy can interfere in these effects is an important step in the development of new treatment for aortic aneurysm. ..
- Comprehensive Magnetic Resonance in PADChristopher Kramer; Fiscal Year: 2008..Improving the health outcomes and quality of life in patients with PAD is a major goal of this proposal. ..
- Clinical Research Using Non-Fourier 3D Cardiac MRIFrank Rybicki; Fiscal Year: 2007..unreadable] [unreadable]..
- Mechanism of Myocardial Angiogenesis in Transgenic/Knockout AnimalsNilanjana Maulik; Fiscal Year: 2010..This proposal will provide and will identify important new insights into the cellular and molecular mechanisms of the cardioprotection provided by VEGF signaling through important candidate genes. ..
- The Effect of Statins on Skeletal Muscle FunctionPAUL DAVIS THOMPSON; Fiscal Year: 2010....
- Contrast-enhanced Ultrasound Assessment of AngiogenesisJonathan Lindner; Fiscal Year: 2007..These studies will also validate the potential use of targeted contrast ultrasound for non-invasively evaluating new pro-angiogenic treatments and for guiding their use in patients. [unreadable] [unreadable]..
- PARASPINAL MUSCLE DENERVATION AND SYMPTOMS IN LUMBAR SSAndrew Haig; Fiscal Year: 2005..Subjects will repeat the test battery (MRI, EMG, and clinical evaluation) approximately 18 months later. Appropriate statistics will test each of the four hypotheses. ..
- Paraspinal Denervation in Low Back PainAndrew J Haig; Fiscal Year: 2010..The results will help doctors avoid unnecessary surgery and help scientists to understand more about how spinal stenosis disables so many older people. ..