aortic diseases

Summary

Top Publications

  1. ncbi Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients
    Mohamed M Nasrallah
    Department of Nephrology, School of Medicine, Kasr El Aini School of Medicine, Cairo University, Cairo, Egypt
    Nephrol Dial Transplant 25:2679-85. 2010
  2. pmc Thoracic aortic calcification and coronary heart disease events: the multi-ethnic study of atherosclerosis (MESA)
    Matthew J Budoff
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA, United States
    Atherosclerosis 215:196-202. 2011
  3. ncbi Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve
    Hisayo Yasuda
    Department of Cardiology, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Circulation 108:II291-4. 2003
  4. pmc Vitamin D receptor activators can protect against vascular calcification
    Suresh Mathew
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 19:1509-19. 2008
  5. ncbi Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto and Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Thorac Cardiovasc Surg 126:797-806. 2003
  6. ncbi Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality
    Raul D Santos
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 209:131-5. 2010
  7. ncbi Single gene disorders of the aortic wall
    Marc K Halushka
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cardiovasc Pathol 21:240-4. 2012
  8. ncbi Comparing coronary artery calcium and thoracic aorta calcium for prediction of all-cause mortality and cardiovascular events on low-dose non-gated computed tomography in a high-risk population of heavy smokers
    Peter C Jacobs
    Julius Center for Health Sciences and Primary Care, Department of Radiology, University Medical Center Utrecht, Netherlands
    Atherosclerosis 209:455-62. 2010
  9. pmc Relationship between coronary artery and descending thoracic aortic calcification as detected by computed tomography: the Multi-Ethnic Study of Atherosclerosis
    Junichiro Takasu
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    Atherosclerosis 204:440-6. 2009
  10. pmc Aortic arch plaques and risk of recurrent stroke and death
    Marco R Di Tullio
    Division of Cardiology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Circulation 119:2376-82. 2009

Research Grants

Detail Information

Publications270 found, 100 shown here

  1. ncbi Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients
    Mohamed M Nasrallah
    Department of Nephrology, School of Medicine, Kasr El Aini School of Medicine, Cairo University, Cairo, Egypt
    Nephrol Dial Transplant 25:2679-85. 2010
    ..We conducted this study to investigate the relationship between FGF-23 and aortic calcification in a standard haemodialysis setting...
  2. pmc Thoracic aortic calcification and coronary heart disease events: the multi-ethnic study of atherosclerosis (MESA)
    Matthew J Budoff
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA, United States
    Atherosclerosis 215:196-202. 2011
    ..Few studies have evaluated interactions or independent incremental risk for coronary and thoracic aortic calcification (TAC). The independent predictive value of TAC for CHD events is not well-established...
  3. ncbi Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve
    Hisayo Yasuda
    Department of Cardiology, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Circulation 108:II291-4. 2003
    ..Patients with bicuspid aortic valve (BAV) have been frequently complicated with ascending aortic dilation possibly because of hemodynamic burdens by aortic stenosis (AS) or regurgitation (AR) or congenital fragility of the aortic wall...
  4. pmc Vitamin D receptor activators can protect against vascular calcification
    Suresh Mathew
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 19:1509-19. 2008
    ..We conclude that low, clinically relevant dosages of calcitriol and paricalcitol may protect against CKD-stimulated vascular calcification...
  5. ncbi Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto and Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Thorac Cardiovasc Surg 126:797-806. 2003
    ..In bicuspid aortic valve disease a deficiency of fibrillin-1 and increased matrix metalloproteinase matrix degradation might result in aortic degeneration and dilatation...
  6. ncbi Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality
    Raul D Santos
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 209:131-5. 2010
    ..However, the predictive value of thoracic aorta calcification (TAC), which can be additionally identified without further scanning during assessment of CAC, is unknown...
  7. ncbi Single gene disorders of the aortic wall
    Marc K Halushka
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cardiovasc Pathol 21:240-4. 2012
    ..The aim is to briefly describe the historical record and physical manifestations and then focus on cardiovascular complications, the causative genes, and current research into these entities...
  8. ncbi Comparing coronary artery calcium and thoracic aorta calcium for prediction of all-cause mortality and cardiovascular events on low-dose non-gated computed tomography in a high-risk population of heavy smokers
    Peter C Jacobs
    Julius Center for Health Sciences and Primary Care, Department of Radiology, University Medical Center Utrecht, Netherlands
    Atherosclerosis 209:455-62. 2010
    ..This study compared CAC and TAC as independent predictors of all-cause mortality and cardiovascular events in a population of heavy smokers using low-dose, non-gated CT...
  9. pmc Relationship between coronary artery and descending thoracic aortic calcification as detected by computed tomography: the Multi-Ethnic Study of Atherosclerosis
    Junichiro Takasu
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    Atherosclerosis 204:440-6. 2009
    ..Previous studies demonstrate that DTAC is associated with obstructive CAD and coronary risk factors. However, no prior studies have examined the association of CAC and DTAC as detected by cardiac CT in a large population-based cohort...
  10. pmc Aortic arch plaques and risk of recurrent stroke and death
    Marco R Di Tullio
    Division of Cardiology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Circulation 119:2376-82. 2009
    ..Aortic arch plaques are a risk factor for ischemic stroke. Although the stroke mechanism is conceivably thromboembolic, no randomized studies have evaluated the efficacy of antithrombotic therapies in preventing recurrent events...
  11. ncbi Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data
    Susanna S Wang
    Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
    Circ Res 101:e11-30. 2007
    ..Thus, global gene expression in peripheral tissues can reflect the systemic perturbations that contribute to atherosclerosis...
  12. ncbi Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions
    Carmen Roncal
    Vesalius Research Center, VIB, KULeuven, Campus Gasthuisberg, Herestraat 49, Box 912, 3000 Leuven, Belgium
    Cardiovasc Res 86:29-36. 2010
    ..Previous gene-inactivation studies revealed that the loss of PlGF delays atherosclerotic lesion development and inhibits macrophage infiltration, but the activity of an anti-PlGF antibody (alphaPlGF mAb) has not been evaluated yet...
  13. ncbi Differential effects of vitamin D receptor activators on vascular calcification in uremic rats
    M Mizobuchi
    Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Kidney Int 72:709-15. 2007
    ..Hence, different VDRAs have different effects on vascular calcification in uremic rats. The effects are independent of the serum calcium-phosphate product suggesting independent mechanisms...
  14. ncbi Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor
    Alan Daugherty
    Division of Cardiovascular Medicine, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
    Circulation 110:3849-57. 2004
    ..We hypothesized that hypercholesterolemia stimulates the production of angiotensin peptides to provide a rationale for the profound effect of AT1A receptor deficiency on atherogenesis...
  15. ncbi Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions
    Masafumi Takeda
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 30:2495-503. 2010
    ..To determine whether the administration of an active form of vitamin D(3) (calcitriol) could prevent atherosclerosis through anti-inflammatory actions...
  16. ncbi Predictors of ascending aortic dilatation with bicuspid aortic valve: a wide spectrum of disease expression
    Alessandro Della Corte
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, V Monaldi Hospital, Via L Bianchi, 80131 Naples, Italy
    Eur J Cardiothorac Surg 31:397-404; discussion 404-5. 2007
    ..This study aimed to describe the features and identify the predictors of ascending aorta dilatation in patients with congenital bicuspid aortic valve (BAV)...
  17. ncbi Aortic calcification in haemodialysis patients with diabetes mellitus
    Hiromichi Taniwaki
    Inoue Hospital, Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Nephrol Dial Transplant 20:2472-8. 2005
    ..This study examined the risk factors of aortic calcification in a large number of haemodialysis patients, and compared risk factors between diabetic and non-diabetic patients...
  18. ncbi Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone
    Shlomo Keidar
    Lipid Research Laboratory, Technion Faculty of Medicine, the Rappaport Family Institute for Research in Medical Sciences and Rambam Medical Center, Haifa, Israel
    Circulation 109:2213-20. 2004
    ..We questioned the effect and mechanisms of action of administration of aldosterone to apolipoprotein E-deficient (E(0)) mice on their macrophages and aorta oxidative status and the ability of pharmacological agents to block this effect...
  19. ncbi Coronary artery, aortic wall, and valvular calcification in nondialyzed individuals with type 2 diabetes and renal disease
    Raffi Merjanian
    Division of Nephrology and Hypertension, Department of Pediatrics, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90502, USA
    Kidney Int 64:263-71. 2003
    ..We undertook this study to test the hypothesis that vascular and valvular calcification begins and is often severe long before diabetic renal disease progresses to ESRD...
  20. ncbi Aortoesophageal fistula after thoracic aortic stent-graft placement: a rare but catastrophic complication of a novel emerging technique
    Holger Eggebrecht
    Department of Cardiology, West German Heart Center Essen, Essen, Germany
    JACC Cardiovasc Interv 2:570-6. 2009
    ..Our goal was to report characteristics and outcomes of 6 patients with aortoesophageal fistula (AEF) after thoracic endovascular aortic repair (TEVAR)...
  21. ncbi Effect of aortic taper on patterns of blood flow and wall shear stress in rabbits: association with age
    Véronique Peiffer
    Department of Aeronautics, Imperial College London, South Kensington Campus, United Kingdom
    Atherosclerosis 223:114-21. 2012
    ..The distribution of atherosclerotic lesions changes with age in human and rabbit aortas. We investigated if this can be explained by changes in patterns of blood flow and wall shear stress...
  22. ncbi The impact of epiaortic ultrasonographic scanning on the risk of perioperative stroke
    Bartolo Zingone
    Division of Cardiac Surgery, Ospedali Riuniti, Strada di Fiume 447, 34100 Trieste, Italy
    Eur J Cardiothorac Surg 29:720-8. 2006
    ..To assess the impact of epiaortic scanning on the incidence of perioperative stroke in patients undergoing cardiac surgery...
  23. ncbi Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease
    C Iribarren
    Division of Research, Kaiser Permanente Medical Care Program, 3505 Broadway, Oakland, CA 94611
    JAMA 283:2810-5. 2000
    ..However, the incremental predictive value of vascular calcification, beyond traditional coronary risk factors, is not clearly established...
  24. ncbi Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling
    Alessandro Della Corte
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, V Monaldi Hospital, Naples, Italy
    J Thorac Cardiovasc Surg 135:8-18, 18.e1-2. 2008
    ..The present study examined temporal and spatial patterns of extracellular matrix and smooth muscle cell changes in the ascending aorta with bicuspid and tricuspid aortic valve stenosis...
  25. ncbi Progression of coronary artery calcification and thoracic aorta calcification in kidney transplant recipients
    Céline Maréchal
    Division of Nephrology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain Medical School, Brussels, Belgium
    Am J Kidney Dis 59:258-69. 2012
    ..Longitudinal studies of vascular calcification in KTRs are few and small and have short follow-up. We assessed the evolution of coronary artery (CAC) and thoracic aorta calcification and their determinants in a cohort of prevalent KTRs...
  26. ncbi Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis
    Kazuhiro Yamada
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, and Koga General Hospital, Japan
    Nephrol Dial Transplant 22:2032-7. 2007
    ..It is not known whether acute changes of the serum calcium concentration before and after HD (DeltaCa) are associated with the development of aortic calcification...
  27. ncbi Efficacy of intraoperative epiaortic ultrasound scanning for preventing stroke after coronary artery bypass surgery
    Atsushi Yamaguchi
    Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Ann Thorac Cardiovasc Surg 15:98-104. 2009
    ..The aim of this study was to clarify the efficacy of intraoperative epiaortic ultrasound scanning (EAS) for preventing cerebral emboli following coronary artery bypass grafting (CABG)...
  28. ncbi Increased aortic pulse wave velocity is associated with silent cerebral small-vessel disease in hypertensive patients
    Léon H G Henskens
    Division of General Internal Medicine, Maastricht University Medical Centre, and Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Hypertension 52:1120-6. 2008
    ..In conclusion, aortic stiffness is independently associated with manifestations of cerebral small-vessel disease in hypertensive patients, linking systemic large- to cerebral small-artery disease...
  29. ncbi Population-based study of the relationship between atherosclerotic aortic debris and cerebrovascular ischemic events
    George W Petty
    Division of Cerebrovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 81:609-14. 2006
    ..To assess the validity of the suggestion that protruding atheromatous material in the thoracic aorta is an important cause of cerebrovascular ischemic events (CIEs) (ie, transient ischemic attack or ischemic stroke)...
  30. ncbi Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review
    Marina Cecelja
    King s College London British Heart Foundation Centre, Cardiovascular Division, Department of Clinical Pharmacology, St Thomas Hospital, London, United Kingdom
    Hypertension 54:1328-36. 2009
    ..The prognostic value of cfPWV may relate to a process of arterial ageing unrelated to classic risk factors other than hypertension...
  31. ncbi Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice
    S Bonthu
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242 1081, USA
    Arterioscler Thromb Vasc Biol 17:2333-40. 1997
    ..We speculate that other factors, such as the absence of LDL receptors, may contribute to the differences in the extent of atherosclerosis in these two models of hyperlipidemia...
  32. ncbi Retrograde embolism from the descending aorta: visualization by multidirectional 3D velocity mapping in cryptogenic stroke
    Andreas Harloff
    Department of Neurology and Clinical Neurophysiology, University Hospital Freiburg, Freiburg, Germany
    Stroke 40:1505-8. 2009
    ..The purpose of this study was to determine the role of plaques >or=4 mm and thrombi (complex plaques) in the descending aorta (DAo) as an embolic high-risk source for stroke...
  33. ncbi Echocardiography in aortic diseases: EAE recommendations for clinical practice
    Arturo Evangelista
    Servei de Cardiologia, Hospital Vall d Hebron, P degrees Vall d Hebron 119, 08035 Barcelona, Spain
    Eur J Echocardiogr 11:645-58. 2010
    Echocardiography plays an important role in the diagnosis and follow-up of aortic diseases. Evaluation of the aorta is a routine part of the standard echocardiographic examination...
  34. ncbi Thoracic aortic calcium versus coronary artery calcium for the prediction of coronary heart disease and cardiovascular disease events
    Nathan D Wong
    Division of Cardiology, University of California, Irvine, California, USA
    JACC Cardiovasc Imaging 2:319-26. 2009
    ..This study compared the ability of coronary artery calcium (CAC) and thoracic aortic calcium (TAC) to predict coronary heart disease (CHD) and cardiovascular disease (CVD) events...
  35. ncbi Aortic dilatation and dissection in Turner syndrome
    Lea Ann Matura
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Circulation 116:1663-70. 2007
    ..It is unknown whether aortic dilatation precedes acute aortic dissection in TS and, if so, what specific diameter predicts impending deterioration...
  36. ncbi Utility of left subclavian artery revascularization in association with endoluminal repair of acute and chronic thoracic aortic pathology
    Brian G Peterson
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Vasc Surg 43:433-9. 2006
    ..Various methods have been used to address this issue. We report our experience with subclavian artery revascularization in association with endoluminal repair of acute and chronic thoracic aortic pathology...
  37. ncbi Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice
    Sven Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 110:3062-7. 2004
    ..Angiotensin II type 1 (AT1) receptor activation is potentially involved in the multifactorial pathogenesis of atherosclerosis...
  38. ncbi The effects of sevelamer and calcium acetate on proxies of atherosclerotic and arteriosclerotic vascular disease in hemodialysis patients
    Glenn M Chertow
    Division of Nephrology, Moffitt Long Hospitals and UCSF Mt Zion Medical Center, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Nephrol 23:307-14. 2003
    ..Whether the specific calcium preparation (acetate vs. carbonate) might influence the likelihood of progressive calcification was debated...
  39. pmc Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease
    Ling Li
    Departments of Medicine, Pharmacology, and Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Pathol 163:2155-64. 2003
    ..Our results suggest that synergistic mechanisms may be involved in the pathogenesis of atherosclerosis and AD. These findings may have important implications in the prevention and treatment of cardiovascular diseases as well as AD...
  40. pmc Relation of aortic wall thickness and distensibility to cardiovascular risk factors (from the Multi-Ethnic Study of Atherosclerosis [MESA])
    Ashkan A Malayeri
    Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 102:491-6. 2008
    ..Decreased AD was further associated with current smoking, African American ethnicity, and higher high-density lipoprotein cholesterol level...
  41. ncbi Atherosclerosis of the aorta: risk factor, risk marker, or innocent bystander? A prospective population-based transesophageal echocardiography study
    Irene Meissner
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 44:1018-24. 2004
    ..The goal of this study was to investigate whether complex aortic atherosclerosis is associated with increased risk of vascular events in a non-selected population...
  42. pmc Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events
    Venkatesh Mani
    Imaging Science Laboratories Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA
    J Cardiovasc Magn Reson 11:10. 2009
    ..The purpose of this study was to determine if patients with traditional risk factors and prior MACE had increased cardiovascular magnetic resonance (CMR) plaque burden measures compared to patients with risk factors but no prior events...
  43. ncbi Quantitative assay for mouse atherosclerosis in the aortic root
    Julie Baglione
    Department of Cell Biology, The Cleveland Clinic Foundation, OH, USA
    Methods Mol Med 129:83-95. 2006
    ..Here, we provide the detailed methods for the quantitative analysis of mouse aortic root lesion area...
  44. ncbi Chondrocyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic rats
    Ellen Neven
    Department of Pathophysiology, University of Antwerp, Wilrijk, Belgium
    Arterioscler Thromb Vasc Biol 30:1741-50. 2010
    ..To investigate cell biological changes in calcified aortas of rats that experienced chronic renal failure...
  45. ncbi Studies of the human aortic intima by a direct quantitative assay of mutant alleles in the mitochondrial genome
    M Sazonova
    Institute of General Pathology and Pathophysiology RAMS, Moscow, Russia
    Atherosclerosis 204:184-90. 2009
    ....
  46. ncbi Aortic dilatation in patients with bicuspid aortic valve
    Moreno Cecconi
    Presidio Monospecialistico di Alta Specializzazione G M Lancisi, Ospedali Riuniti Umberto I G M Lancisi G Salesi, Ancona, Italy
    J Cardiovasc Med (Hagerstown) 7:11-20. 2006
    ..However, the optimal timing of aortic surgery in BAV patients remains uncertain because of the limited data available on the natural history of asymptomatic aortic dilatation...
  47. ncbi Aortoesophageal fistula secondary to stent-graft repair of the thoracic aorta
    Holger Eggebrecht
    Department of Cardiology, West German Heart Center, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    J Endovasc Ther 11:161-7. 2004
    ..To report the incidence and management of aortoesophageal fistula (AEF) secondary to endovascular stent-graft repair of the descending thoracic aorta...
  48. ncbi The serum level of bone-specific alkaline phosphatase activity is associated with aortic calcification in osteoporosis patients
    Kousuke Iba
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Japan
    J Bone Miner Metab 22:594-6. 2004
    ..Bone-specific alkaline phosphatase is the most important marker for osteoblast differentiation; furthermore, the serum level of its activity may reflect the process of calcification of the aorta in osteoporosis patients...
  49. ncbi Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary results
    Maurizio Cotrufo
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Italy
    J Thorac Cardiovasc Surg 130:504-11. 2005
    ..This study aimed to assess extracellular matrix protein expression patterns at the convexity (right anterolateral wall) and the concavity of the dilated ascending aorta in patients with bicuspid aortic valve disease...
  50. ncbi Aortic constriction exacerbates atherosclerosis and induces cardiac dysfunction in mice lacking apolipoprotein E
    Jiao Hui Wu
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill 27599 7525, USA
    Arterioscler Thromb Vasc Biol 22:469-75. 2002
    ..Our study also suggests that apolipoprotein E plays an important role in modulating cardiac hypertrophy...
  51. ncbi Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy
    Joao A C Lima
    Cardiology Division of the Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circulation 110:2336-41. 2004
    ..We hypothesized that statin-induced AP regression can be monitored by MRI and detected earlier than previously reported and is significantly associated with its lipid-lowering effect...
  52. ncbi Aortic allograft vasculopathy is mediated by CD8(+) T cells in Cyclosporin A immunosuppressed mice
    Ellen L Vessie
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Transpl Immunol 15:35-44. 2005
    ..The in vitro data suggest that the indirect pathway remains intact in this population of CyA resistant CD8(+) T cells...
  53. ncbi The influence of mechanical properties on wall stress and distensibility of the dilated ascending aorta
    Ruth J Okamoto
    Department of Mechanical Engineering, Washington University, Campus Box 1185, One Brookings Drive, St Louis, MO 63130 4899, USA
    J Thorac Cardiovasc Surg 126:842-50. 2003
    ..We sought to determine how intrinsic mechanical properties of dilated ascending aorta influence in vivo distensibility and wall stress, potential contributing factors to the risk of aortic rupture and dissection...
  54. ncbi Surgical management of primary aortoesophageal fistula secondary to thoracic aneurysm
    M J Reardon
    Department of Surgery, Baylor College of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    Ann Thorac Surg 69:967-70. 2000
    ..We report a successful repair of primary aortoesophageal fistula, secondary to descending thoracic aortic aneurysm, and review the evolution of management since the three previously reported successful repairs at our institution...
  55. ncbi Importance of dural ectasia in phenotypic assessment of Marfan's syndrome
    R Fattori
    Institute of Radiology, University Hospital S Orsola, Bologna, Italy
    Lancet 354:910-3. 1999
    ..Dural ectasia has been classified as a major diagnostic criterion; however, its prevalence is not known. We aimed to identify the true prevalence of dural ectasia in Marfan's syndrome, and to investigate its relation to aortic pathology...
  56. ncbi Restricted cusp motion in right-left type of bicuspid aortic valves: a new risk marker for aortopathy
    Alessandro Della Corte
    Department of Cardiothoracic Sciences, Second University of Naples c o Monaldi Hospital, Naples, Italy
    J Thorac Cardiovasc Surg 144:360-9, 369.e1. 2012
    ..This study searched for early imaging predictors of aortopathy in patients with a bicuspid aortic valve with right-left coronary cusp fusion, the most common morphotype...
  57. ncbi Arterial inflow via an axillary artery graft for the severely atheromatous aorta
    Y R Baribeau
    New England Heart Institute, Catholic Medical Center, Manchester, New Hampshire, USA
    Ann Thorac Surg 66:33-7. 1998
    ..Strategy for severe aortic atheromatous disease identified by intraoperative epiaortic ultrasound remains to be determined. We used axillary artery inflow through graft interposition in an attempt to avoid potential embolization...
  58. ncbi Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burden
    S K Chan
    Department of Medicine (Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Cardiovasc Magn Reson 3:331-8. 2001
    ..62-0.85). These data demonstrate that MRI is a reproducible technique for assessing aortic anatomy and total aortic atherosclerosis, but increased slice density should be considered if serial evaluation of slice-specific data is desired...
  59. ncbi Pulse pressure is an independent predictor for the progression of aortic wall calcification in patients with controlled hyperlipidemia
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Hypertension 43:536-40. 2004
    ..389, P<0.001) among the blood pressure components. These results suggested that increase in pulse pressure promotes the progression of vascular calcification...
  60. ncbi Management of porcelain aorta and calcified great vessels in coronary artery bypass grafting with off-pump and no-touch technology
    H B Bittner
    Division of Cardiovascular and Thoracic Surgery, University of Minnesota, Minneapolis 55455, USA
    Ann Thorac Surg 72:1378-80. 2001
    ..We did successful off-pump coronary revascularization in this patient with severely calcified ascending aorta and great vessels, subtotal aortobiiliac stenoses, a history of previous stroke, and right carotid endarterectomy...
  61. pmc Relationship between hemodynamics and atherosclerosis in aortic arches of apolipoprotein E-null mice on 129S6/SvEvTac and C57BL/6J genetic backgrounds
    Hirofumi Tomita
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, CB 7525, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Atherosclerosis 220:78-85. 2012
    ..We investigated the relationships between hemodynamics and differential plaque development at the aortic arch of apolipoprotein E (apoE)-null mice on 129S6/SvEvTac (129) and C57BL/6J (B6) genetic backgrounds...
  62. ncbi Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients
    Glenn M Chertow
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Kidney Int 62:245-52. 2002
    ..Cardiovascular disease is frequent and severe in patients with end-stage renal disease. Disorders of mineral metabolism may contribute by promoting cardiovascular calcification...
  63. ncbi Successful repair of an aortoesophageal fistula with aneurysm from esophageal diverticulum
    Fuyuhiko Yasuda
    Department of Thoracic and Cardiovascular Surgery and The Second Department of Surgery, Mie University School of Medicine, Tsu, Japan
    Ann Thorac Surg 73:637-9. 2002
    ..In this case, esophageal diverticulum was diagnosed before the development of an aortoesophageal fistula associated with an aneurysm...
  64. ncbi Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo
    Jun o Deguchi
    Donald W Reynolds Cardiovascular Clinical Research Center, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 114:55-62. 2006
    ..Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications...
  65. ncbi Uncommon congenital and acquired aortic diseases: role of multidetector CT angiography
    Eric T Kimura-Hayama
    Department of Radiology, Division of Computed Tomography, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Col Seccion XVI, Mexico City, Mexico
    Radiographics 30:79-98. 2010
    ..Radiologists should also be familiar with uncommon aortic diseases, which are divided into those that are congenital in origin and acquired disorders, and with their findings ..
  66. ncbi An unusual origin of proximal coronary bypass anastomosis in a patient with porcelain aorta: how we solved the problem
    Pavle Kovacević
    Department of Cardiovascular Surgery, Insitute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica
    Med Pregl 64:215-8. 2011
    ..Proximal venous anastomosis was created in the Dacron prosthesis of the right carotid artery. Perfusion of the patient was achieved via the graft sutured at the right subclavian artery due to impossibility of direct aortic cannulation...
  67. doi Seasonal variation in occurrence of aortic diseases: the database of hospital discharge data of the Emilia-Romagna region, Italy
    Roberto Manfredini
    Department of Internal Medicine, Hospital of the Delta, Azienda Unità Sanitaria Locale di Ferrara, Ferrara, Italy
    J Thorac Cardiovasc Surg 135:442-4. 2008
  68. ncbi Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Circulation 112:3722-8. 2005
    ..Aortic stiffness and small-artery structure and function share various risk factors; however, relations between these 2 measures of vascular function are complex and incompletely understood...
  69. ncbi Effect of oral calcium carbonate on aortic calcification in apolipoprotein E-deficient (apoE-/-) mice with chronic renal failure
    Olivier Phan
    INSERM, Unit 845, Necker Hospital, Universite Paris V, Paris, France
    Nephrol Dial Transplant 23:82-90. 2008
    ..The aim of this study was to reexamine the role of calcium carbonate in vascular calcification and to analyse its effect on aortic calcification-related gene expression in chronic renal failure (CRF)...
  70. ncbi Successful one-stage operation of aortoesophageal fistula from thoracic aneurysm using a rifampicin-soaked synthetic graft
    Takehiro Inoue
    Department of Cardiovascular Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    Interact Cardiovasc Thorac Surg 7:322-4. 2008
    ..This is the original report of the surgical repair of aortoesophageal fistula using a rifampicin-soaked graft...
  71. ncbi A novel technique of coronary revascularization in porcelain aorta: report of two cases
    Meng Yu Wu
    Division of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5 Fushing Street, Gueishan Shiang, Taoyuan, Taipei, 333, Taiwan
    Surg Today 38:157-60. 2008
    ..This study describes the experience of successful coronary revascularization using bilateral internal thoracic arteries and modified with a composite graft in two patients with a severely atherosclerotic ascending aorta...
  72. ncbi 1,25-Dihydroxyvitamin D3-induced aortic calcifications in experimental uremia: up-regulation of osteoblast markers, calcium-transporting proteins and osterix
    Hong Zebger-Gong
    Department of Pediatric Nephrology, Campus Virchow Klinikum, Berlin, Germany
    J Hypertens 29:339-48. 2011
    ..We studied mechanisms involved in vitamin D-related vascular calcifications in vivo and in vitro...
  73. ncbi Epiaortic scanning modifies planned intraoperative surgical management but not cerebral embolic load during coronary artery bypass surgery
    George Djaiani
    Department of Anesthesiology, Toronto General Hospital, Eaton North 3 410, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
    Anesth Analg 106:1611-8. 2008
    ..We sought to determine the role of epiaortic ultrasound scanning for reducing cerebral embolic load, and whether its use leads to changes of planned intraoperative surgical management in patients undergoing CABG surgery...
  74. ncbi Smoking, smoking cessation and aortic arch calcification in older Chinese: the Guangzhou Biobank Cohort Study
    Chao Qiang Jiang
    Guangzhou No 12 Hospital Guangzhou Occupational Disease Prevention and Treatment Centre, Guangzhou, People s Republic of China
    Atherosclerosis 202:529-34. 2009
    ..To study the association between smoking, smoking cessation and aortic arc calcification (AAC) in an older Chinese population...
  75. ncbi Left common carotid artery as inflow site in coronary artery bypass grafting
    Marco Agrifoglio
    Department of Cardiac Surgery, Centro Cardiologico Monzino, University of Milan, Milan, Italy
    Ann Thorac Surg 82:2298-300. 2006
    ..This technique permitted avoidance of ascending aortic manipulation and reduce the risk of atheromatous embolization...
  76. ncbi 'No touch' techniques for porcelain ascending aorta: comparison between cardiopulmonary bypass with femoral artery cannulation and off-pump myocardial revascularization
    Oren Lev-Ran
    Department of Cardiothoracic Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Card Surg 17:370-6. 2002
    ..Off-pump coronary artery bypass grafting (OPCAB) confers the benefits of avoiding aortic cannulation and clamping, and may therefore attenuate this risk...
  77. ncbi Clinical evaluation of aortic diseases using nonenhanced MRA with ECG-triggered 3D half-Fourier FSE
    J Urata
    Diagnostic Imaging Center, Saiseikai Kumamoto Hospital, Kumamoto, Japan
    J Magn Reson Imaging 14:113-9. 2001
    ..ECG)-triggered 3D half-Fourier fast spin-echo (FSE), was evaluated for the detection and characterization of aortic diseases. Seventy-five consecutive patients with aortic disease underwent the FBI examination on a 1...
  78. ncbi Off-pump axillo-coronary artery bypass grafting with porcelain aorta
    Naruto Matsuda
    Department of Cardiovascular Surgery, Tottori University Hospital, Tottori, Japan
    J Card Surg 20:586-8. 2005
    ..The off-pump axillo-coronary artery bypass grafting seemed to be an appropriate procedure for coronary revascularization with severely diseased ascending aorta...
  79. ncbi Left ventricular hypertrophy is associated with arterial stiffness and vascular calcification in hemodialysis patients
    Kosaku Nitta
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Hypertens Res 27:47-52. 2004
    ..Vascular calcification, which alters the pulsatile dynamics and thereby contributes to an increase in left ventricular load, is the most important contributor to the development of LVH in patients undergoing hemodialysis...
  80. ncbi Validity and usefulness of aortic arch calcification in chest X-ray
    Hiroko Hashimoto
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Atheroscler Thromb 16:256-64. 2009
    ..In addition, the validity of the grading and the relationship of this useful grading to clinical risk factors were evaluated...
  81. ncbi Double coronary endarterectomy on the beating heart in two patients with porcelain aorta
    M Tamim
    Department of Cardiac Surgery, Alkan Hospital, Ankara, Turkey
    Ann Thorac Surg 72:620-1. 2001
    ..In patients with diffuse atherosclerotic coronary artery disease who require endarterectomy, coronary bypass operations can be done safely on the beating heart...
  82. ncbi Endovascular repair of a chronic aortocaval fistula using a thoracic aortic endoprosthesis
    Marc E Mitchell
    Division of Vascular Surgery, University of Mississippi Medical Center, Jackson, MS, USA
    Ann Vasc Surg 23:150-2. 2009
    ..The ACF was successfully treated with an endoprosthesis designed for the thoracic aorta...
  83. ncbi Aortic diseases--do we need MR techniques?
    C A Nienaber
    Department of Internal Medicine, University Hospital Hamburg Eppendorf, Germany
    Herz 25:331-41. 2000
    ..MR imaging, flow-mapping and MR angiography is the ideal tool for noninvasive assessment of any kind of aortic diseases. The technique allows to image the aorta both in the thoracic cage and in the abdominal aspects better than ..
  84. ncbi Natural history of vascular calcification in dialysis and transplant patients
    Sharon M Moe
    Departmrnt of Medicine, Indiana University School of Medicine, 1001 W 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 19:2387-93. 2004
    ..The purpose of the present study was to determine the natural history of coronary artery and aorta calcification by spiral computed tomography (CT) in patients who undergo a renal transplant and patients on haemodialysis...
  85. ncbi A case of unilateral leg edema due to abdominal aortic aneurysm with aortocaval fistula
    Tohru Takaseya
    Department of Surgery, Kurume University School of Medicine, Kurume, Japan
    Ann Thorac Cardiovasc Surg 13:135-8. 2007
    ..ACF is associated with high mortality because it is difficult to control venous bleeding from ACF. Detailed preoperative diagnosis of ACF can provide many advantages to control bleeding from ACF during an operation...
  86. ncbi Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients
    Senji Okuno
    Kidney Center, Shirasagi Hospital, Osaka, Japan
    Am J Kidney Dis 49:417-25. 2007
    ....
  87. ncbi Simple evaluation of aortic arch calcification by chest radiography in hemodialysis patients
    Tetsuya Ogawa
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Hemodial Int 13:301-6. 2009
    ..001) and pulse pressure (F value=4.54, P=0.037) to be significant independent determinants of AoACS. In conclusion, a simple measurement of AoACS may be useful for inoffice imaging to choose a therapeutic regimen in HD patients...
  88. ncbi Risk factors for progression of aortic arch calcification in patients on maintenance hemodialysis and peritoneal dialysis
    Hyun Gyung Kim
    Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Hemodial Int 15:460-7. 2011
    ..The results suggest that patients should be carefully managed from the predialysis stage to prevent AoAC progression and to reduce cardiovascular morbidity...
  89. ncbi Magnetic resonance imaging features of aortic diseases
    Naofumi Matsunaga
    Department of Radiology, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Top Magn Reson Imaging 14:253-66. 2003
    The usefulness of magnetic resonance imaging (MRI) for aortic diseases is discussed, with special attention given to the MRI features of aortic dissection and Takayasu arteritis...
  90. ncbi Combined aortic valve replacement and coronary artery bypass grafting with in situ arterial grafts for porcelain aorta
    Kentaro Tamura
    Department of Cardiovascular Surgery, National Hospital Kure Medical Center, Hiroshima, Japan
    Ann Thorac Cardiovasc Surg 9:206-8. 2003
    ..On-pump beating heart coronary artery bypass grafting (CABG) can be useful especially for combined complex cardiac surgery...
  91. ncbi Aortotomy and endarterectomy of the ascending aorta for aortic valve replacement in a patient with porcelain aorta
    Mikihiko Kudo
    Department of Surgery, Keio University, Shinjuku ku, Tokyo, Japan
    Surg Today 35:1000-3. 2005
    ..During the endarterectomy, we used an elevator designed for hand surgery to exfoliate the calcified intimal plate...
  92. ncbi Management of acute aortic syndrome and chronic aortic dissection
    Ian M Nordon
    St George s Vascular Institute, St James Wing, St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    Cardiovasc Intervent Radiol 34:890-902. 2011
    ..The best imaging techniques and the evolving role of endovascular techniques in the definitive management of AAS are discussed incorporating strategies to reduce perioperative morbidity...
  93. ncbi Atherosclerotic enlargement of the human abdominal aorta
    C K Zarins
    Department of Surgery, Division of Vascular Surgery, Suite H 3600, Stanford University Medical Center, Stanford, CA 94305 5642, USA
    Atherosclerosis 155:157-64. 2001
    ..These changes may be predisposing factors for the preferential development of subsequent aneurysmal dilation in the abdominal aorta...
  94. ncbi Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation. SPAF TEE Investigators. Stroke Prevention and Atrial Fibrillation. Transesophageal echocardiography
    J L Blackshear
    Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Am J Cardiol 83:453-5, A9. 1999
    ..9%/year; 95% CI 3.0 to 12) than those on combination low-dose warfarin (international normalized ratio <1.5) plus aspirin (17.3%/year; 95% CI 11 to 27; p = 0.01)...
  95. ncbi Aortoesophageal fistula: an uncommon complication after stent-graft repair of an aortic thoracic aneurysm
    Guillermo Isasti
    Servicio de Cardiologia, Hospital Virgen de la Victoria, Campus Teatinos s n, 29010 Malaga, Spain
    Interact Cardiovasc Thorac Surg 9:683-4. 2009
    ..To report the incidence and management of aortoesophageal fistula (AEF) secondary to endovascular stent-graft repair of the descending thoracic aorta...
  96. ncbi Aortic plaque morphology and vascular events: a follow-up study in patients with ischemic stroke. FAPS Investigators. French Study of Aortic Plaques in Stroke
    A Cohen
    Service de cardiologie, Saint Antoine University and Medical School, Paris, France
    Circulation 96:3838-41. 1997
    ..The purpose of this study was to evaluate the impact, if any, of plaque morphology (ulceration, hypoechoic plaques or calcification) on the risk of subsequent vascular events...
  97. pmc Atherosclerotic disease of the proximal aorta and the risk of vascular events in a population-based cohort: the Aortic Plaques and Risk of Ischemic Stroke (APRIS) study
    Cesare Russo
    Departments of Medicine, Columbia University, New York, NY 10032, USA
    Stroke 40:2313-8. 2009
    ..However, this association in the general population is unclear. We sought to assess whether proximal aortic plaques are associated with vascular events in a community-based cohort...
  98. ncbi Mobile aortic atheroma and systemic emboli: efficacy of anticoagulation and influence of plaque morphology on recurrent stroke
    F A Dressler
    Department of Internal Medicine and Pathology, Saint Louis University Health Sciences Center, Missouri 63110, USA
    J Am Coll Cardiol 31:134-8. 1998
    ..We sought to determine the influence of plaque morphology and warfarin anticoagulation on the risk of recurrent emboli in patients with mobile aortic atheroma...
  99. ncbi Endovascular treatment of thoracic aortic disease: four years of experience
    Alessandro S Bortone
    Dipartimento Emergenza e Trapianti d Organo, Sezione di Cardiochirurgia, Piazza Giulio Cesare 11 70124 Bari, Italy
    Circulation 110:II262-7. 2004
    ..The aim of this retrospective study is to investigate efficacy and middle-term results of the stent graft treatment for diseases of descending thoracic aorta...
  100. ncbi Treatment of type II endoleaks associated with left subclavian artery coverage during thoracic aortic stent grafting
    Mark D Peterson
    Division of Cardiovascular Surgery, Arizona Heart Institute, Phoenix, Ariz 85006, USA
    J Thorac Cardiovasc Surg 136:1193-9. 2008
    ..It is currently unclear how best to manage these patients to prevent persistent risk of aneurysm expansion or rupture. We report our experience with a minimally invasive endovascular repair of the covered left subclavian artery...
  101. ncbi New insight in aetiopathogenesis of aortic diseases
    E Allaire
    Surgical Research Center, Paris 12 University, CNRS EAC 7054, 8 rue du General Sarrail, 94010 Creteil Cedex, France
    Eur J Vasc Endovasc Surg 37:531-7. 2009
    ..This article focusses on aneurysms and dissections, and excludes causes related to infection, systemic inflammatory diseases and trauma...

Research Grants69

  1. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..We will use MFS as a model for aortic diseases in the current proposal since we have already shown that a comprehensive understanding of this disorder ..
  2. Genetic Predisposition To Thoracic Aortic Aneurysms/Dissections
    Dianna M Milewicz; Fiscal Year: 2013
    ..Through these studies, we will improve understanding of the etiology of aortic diseases and provide data critical for the proper clinical management of familia thoracic aortic disease.
  3. Myocardin Related Transcription Factor Function in the Vasculature
    Michael S Parmacek; Fiscal Year: 2013
    ..These studies are directly relevant to understanding vascular proliferative syndromes including atherosclerosis, common forms of congenital heart disease and aortic diseases.
  4. Roles of SMC TGF-beta Signaling in Aortic Health and Aneurysm Formation
    David A Dichek; Fiscal Year: 2013
    ..Dysfunction and destruction of SMC are common features of aortic diseases. Accordingly, strategies that prevent SMC dysfunction and destruction will likely preserve aortic health...
  5. Mathematical modeling and computer simulation of aortic dissection
    BOYCE EUGENE GRIFFITH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Management of aortic diseases has progressed dramatically since the first successful, reproducible surgical intervention in 1956;however, while our understanding of the genetic and cellular bases of ..
  6. Inflammation and Aortic Aneurysm Pathophysiology
    Galina Sukhova; Fiscal Year: 2006
    ..Specific Aims will determine whether differential immune mediator-associated mechanisms triggering proteolytic and apoptotic effectors regulate the development of the two diametrically opposed expressions of aortic diseases-AAA and AOD.
  7. Stress, Sleep and Emerging CVD Risk Factors
    Karen Matthews; Fiscal Year: 2007
    ..The study will provide novel data testing the relationships of daytime stressful events, SDB, and other nocturnal physiological measures with the emerging risk factors and subclinical CVD measured in HeartSCORE. [unreadable] [unreadable]..
  8. Pittsburgh Mind-Body Center-II
    Karen Matthews; Fiscal Year: 2008
    ..Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible. ..
  9. Mineralization studies related to atherosclerosis
    HOWARD HSU; Fiscal Year: 2004
    ..abstract_text> ..
  10. Osteoprotegerin and osteopontin in aortic aneurysm
    Jonathan Golledge; Fiscal Year: 2009
    ..Understanding the role of these calcium-controlling proteins in artery weakness and how drug therapy can interfere in these effects is an important step in the development of new treatment for aortic aneurysm. ..
  11. ECHOCARDIOGRAPHIC STROKE PREDICTORS IN A TRI-ETHNIC COMM
    Marco Di Tullio; Fiscal Year: 2003
    ..This study will be the first prospective cohort study to evaluate the role of multiple echocardiographic risk factors for ischemic stroke in a community of whites, blacks and Hispanics living in the same area. ..
  12. Initiation and Inhibition of Medial Artery Calcification
    Paul Price; Fiscal Year: 2008
    ..abstract_text> ..
  13. MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    Paul Price; Fiscal Year: 2001
    ..The investigators will further study the demonstrated ability of MGP to inhibit calcification in supersaturated solutions, and will investigate the ability of MGP to inhibit matrix vesicle -initiated calcification. ..
  14. Aortic, Cardiovascular Disease and Silent Brain Infarcts
    Marco Di Tullio; Fiscal Year: 2009
    ..The present application will help fill gaps in knowledge on silent brain infarcts and their risk factors in the elderly, and identify subjects at higher risk before a symptomatic stroke or other vascular event occurs. ..
  15. PROGRESSION OF AORTIC ATHEROMA IN STROKE/TIA PATIENTS
    Souvik Sen; Fiscal Year: 2004
    ..Designing of future placebo controlled prospective studies aimed at investigating measures that may be used to treat AA in stroke/TIA patients. ..
  16. GENETIC MECHANISMS OF ESTROGEN ATHEROPROTECTION
    Amparo Villablanca; Fiscal Year: 2003
    ..Advances in our basic understanding of mechanisms of hormone action could lead to more effective strategies for treatment of coronary artery disease in both men and women. ..
  17. Nanoparticles for Molecular MRI of Atherosclerosis
    Zahi Fayad; Fiscal Year: 2008
    ..These studies will provide the basis for future advances in experimental studies of atherosclerogenesis and new clinical applications of non-invasive, in vivo MR imaging of atherosclerotic lesions. [unreadable] [unreadable] [unreadable]..
  18. Hospital and Community Acquired Acute Renal Failure
    Glenn Chertow; Fiscal Year: 2006
    ..This study will efficiently inform the Nephrology community by providing a foundation of fundamental information (ARF definitions, incidence, consequences and costs) upon which a clinical trials network can be built. ..
  19. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
    ..abstract_text> ..
  20. Net Lifetime Health Effects of Alcohol Use & Abuse
    CURTIS ELLISON; Fiscal Year: 2007
    ..The study will produce a unique dataset and will provide information that should improve our knowledge of the net effects of alcohol throughout adult life. ..
  21. MESA Family Study
    Wendy Post; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. SAFER THROMBOLYTIC THERAPY USING PLASMIN
    Victor Marder; Fiscal Year: 2007
    ..We hypothesize and anticipate that plasmin will provide clinically effective thrombolysis without an increased risk of bleeding . ..
  23. Effect of lipid modification on peripheral arterial disease (PAD)
    Christie Ballantyne; Fiscal Year: 2007
    ..Finally, these studies will advance our understanding of the molecular mechanisms of inflammation and thrombosis associated with aggressive lipid modification. ..
  24. Biochemical Heterogeneity in Morbidly Obese Women in the WHI Observational Study
    Rachel Mackey; Fiscal Year: 2008
    ..This will be the first epidemiology study to specifically focus on morbidy obesity Class III unselected for weight reduction, i.e. bariatric surgery, in black and white women. ..
  25. DNA Methylation Profiles in a Polygenic Mouse Model of Diet-Induced Obesity
    Jan Bressler; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. Functional MR in Ischemic Cardiomyopathy
    Paul Grayburn; Fiscal Year: 2007
    ..Despite its known clinical utility for assessing the mechanism and severity of MR, TEE is not currently included in STICH. ..
  27. Machine Learning to Identify Complex Interactions in Genome-Wide Association Data
    David Herrington; Fiscal Year: 2009
    ..Determining specific genetic and/or environmental factors that influence a person's risk of disease may help doctors reduce risk for disease and reveal new treatments for disease. (End of Abstract) ..
  28. 3T Atherosclerotic MRI and Carotid Artery Scoring System
    Chun Yuan; Fiscal Year: 2009
    ....
  29. HDL Increased Plaque Stablization in the Elderly
    Joao Lima; Fiscal Year: 2008
    ..The results of the proposed trial will be directly applicable to developing strategies for plaque stabilization in the elderly who suffer the most from the severe complications of advanced cardiovascular ]therosclerosis. ..
  30. Regional Dysfunction by MRI in Incident Heart Failure
    Joao Lima; Fiscal Year: 2009
    ..These findings will be pivotal to the design of future strategies to forestall progressive myocardial dysfunction and prevent the development of heart failure. ..
  31. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2009
    ..abstract_text> ..
  32. Functional Organization of Cardiovascular Reactivity
    Peter Gianaros; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  33. Homocysteine/Hypertension & Vascular Lesion Formation
    Peter Lin; Fiscal Year: 2008
    ..abstract_text> ..
  34. RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
    Evelyn Talbott; Fiscal Year: 2005
    ..The investigators state that this study has the potential to identify the determinants of early SCA in this high-risk group of women and has important implications for primary as well as secondary prevention. ..
  35. Targeting BCL-XL Expression in Mesothelioma
    W Smythe; Fiscal Year: 2006
    ..Upstream targets regulating bcl-xl expression for use in future therapeutic paradigms may be identified. ..
  36. Estrogen Receptor Variants,HDL, and Atherosclerosis
    David Herrington; Fiscal Year: 2005
    ....
  37. GENCAC - Framingham Field Center
    CURTIS ELLISON; Fiscal Year: 2004
    ..abstract_text> ..
  38. GENCAC - North Carolina Field Center
    Lynne Wagenknecht; Fiscal Year: 2004
    ..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
  39. Genetics of IR in PCOS: The PPAR Pathway
    Evelyn Talbott; Fiscal Year: 2004
    ....
  40. HYPERGEN-BOSTON UNIVERSITY/FRAMINGHAM FIELD CENTER
    CURTIS ELLISON; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  41. Estrogen Receptor Variance and CHD Risk in HERS
    David Herrington; Fiscal Year: 2004
    ..In addition, this information could lead to fundamentally important new knowledge about mechanisms of estrogen action, regulation of HDL cholesterol, and pathogenesis of CHD. ..
  42. REDUCING SPINAL CORD INJURY WITH RETROGRADE PERFUSION
    John Kern; Fiscal Year: 2004
    ..Basic research is needed, however, before applying this technique clinically. ..
  43. Thrombosis Gene Polymorphisms and Early CHD Risk in HERS
    David Herrington; Fiscal Year: 2004
    ....
  44. VENTRICULAR REMODELING IN HEART FAILURE
    Paul Grayburn; Fiscal Year: 2003
    ..abstract_text> ..
  45. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..
  46. Candidate Gene(s) for Pigeon Atherosclerosis
    Samuel Smith; Fiscal Year: 2003
    ..The candidate genes will be cloned and sequenced, and the products or functions deduced from existing genomic databases. ..
  47. IMPROVING HEALTH BEHAVIOR AND OUTCOMES AFTER ANGIOPLASTY
    Mary Charlson; Fiscal Year: 2002
    ..abstract_text> ..
  48. BRAIN ISCHEMIA AND AORTIC ATHEROMATA IN A POPULATION
    GEORGE PETTY; Fiscal Year: 2001
    ..The investigators state that the study will also determine if clinical trials aimed at primary and secondary stroke prevention in these patients are warranted, and if so, assist in their design. ..
  49. Role of MMPs in AngII induced abdominal aortic aneurysms
    Alan Daugherty; Fiscal Year: 2005
    ..The significance of this research relates to delineation of mechanism for AA formation and maturation, with emphasis on potential development of pharmacological treatments of the disease. ..
  50. ER beta selective agonist coronary protection-menopause
    R Hermsmeyer; Fiscal Year: 2005
    ..The new ERbetaA is to be contrasted with PremPro(r) (oral conjugated equine estrogens plus medroxyprogesterone acetate) which failed to provide cardiovascular protection in the Women's Health Initiative. ..
  51. Effects of Statins on AD beyond Cholesterol and Amyloid
    Ling Li; Fiscal Year: 2006
    ..abstract_text> ..
  52. ESTROGEN, INFLAMMATION AND ATHEROSCLEROSIS
    David Herrington; Fiscal Year: 2001
    ....
  53. Senescense and cerebral oxygenation with acute anemia
    Thomas Floyd; Fiscal Year: 2005
    ..We propose to study the effect of AIA on cerebral oxygenation and cognition in young and aged spontaneously hypertensive rats. ..
  54. A central aortic pulse wave velocity measurement device
    Gary Mitchell; Fiscal Year: 2005
    ..This innovative technology will enable accurate diagnosis and risk stratification in a primary care setting and will facilitate further research aimed at evaluating interventions that may reduce conduit vessel stiffness. ..
  55. Proteome Mapping of Heart Failure in Aging
    MARVIN BOLUYT; Fiscal Year: 2005
    ..Identification of proteins involved in aldosterone signaling will lead to the development of new hypotheses for future grant proposals addressing their roles in the development of heart failure in the elderly. ..
  56. Coronary Reactivity and Thromboxane Receptor Expression
    R Hermsmeyer; Fiscal Year: 2005
    ....
  57. Estradiol For Neurocognitive Dysfunction After CABG
    Charles Hogue; Fiscal Year: 2005
    ..The results of this study will evaluate the efficacy and safety of an easily implemented therapy for improving neurologic outcome and quality of life after CABG surgery for postmenopausal women. ..
  58. The Incidence and Progression of Peripheral Venous Disease
    Michael H Criqui; Fiscal Year: 2010
    ..This application builds on the seminal findings in our prevalence study, and since no such incidence data exist, is original and innovative. ..
  59. The Role of Fibulin-5 in Cardiovascular Remodeling
    Hiromi Yanagisawa; Fiscal Year: 2007
    ..abstract_text> ..
  60. Aortic Calcium: epidemiology and progression
    Michael Criqui; Fiscal Year: 2006
    ..abstract_text> ..
  61. Ethnic differences in peripheral arterial disease
    Michael Criqui; Fiscal Year: 2004
    ..This is the first attempt to see if these newer risk markers can explain ethnic differences in PAD. Thus, this application is highly innovative and addresses original hypotheses. ..
  62. The Role of Oxidative Stress in Endothelial Aging
    Hong Yang; Fiscal Year: 2008
    ..Such information is important for understanding the role of ROS in the age-related development of atherosclerosis and could lead to potential strategies of therapy for atherosclerosis. ..
  63. METABOLISM OF SPONTANEOUSLY DAMAGED PROTEINS IN AGING
    Stephen Young; Fiscal Year: 2002
    ..Finally, we propose to ask whether the expression of the repair methyltransferase in the extracellular compartment would limit the accumulation of spontaneous damage to extracellular proteins. ..
  64. Postisoprenylation Processing and the Nuclear Lamina
    Stephen Young; Fiscal Year: 2007
    ..The third aim is to understand the posttranslational processing of lamin B1 and to define the consequences of lamin B1 deficiency in mammals. ..
  65. RAGE and a Novel Tumor Axis
    Ann Schmidt; Fiscal Year: 2005
    ....
  66. THE NHLBI BAY AREA FUNCTIONAL GENOMICS COMSORTIUM
    Stephen Young; Fiscal Year: 2003
    ..The Consortium's resources will be distributed freely to any interested investigator and should provide a catalyst for many different NHLBI-funded research programs. ..
  67. CAAX Protein Processing and Cancer Therapy
    Stephen Young; Fiscal Year: 2007
    ..These studies should define the therapeutic potential of blocking the three different steps of CAAX protein processing. ..
  68. Hutchinson Gilford Progeria Syndrome and Atherosclerosis
    Stephen Young; Fiscal Year: 2009
    ..The PI's laboratory has extensive experience in analyzing atherogenesis in mice and is thrilled with the prospect of exploring mechanisms of atherosclerosis in HGPS. ..
  69. NHLBI Bay Area Functional Genomics Consortium
    Stephen Young; Fiscal Year: 2007
    ..A fourth objective is to generate a limited number of genetically modified mice, for the purpose of defining the relevance of specific genes to cardiopulmonary development and disease (Components 4-6). ..