intracranial aneurysm

Summary

Summary: Congenital or acquired abnormal outpouching of an intracranial blood vessel wall. Saccular (berry) aneurysms are the most common variant, and tend to form at arterial branch points near the base of the brain. Rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE (see also OCULOMOTOR NERVE DISEASES). (From Adams et al., Principles of Neurology, 6th ed, p841)

Top Publications

  1. pmc Biology of intracranial aneurysms: role of inflammation
    Nohra Chalouhi
    Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    J Cereb Blood Flow Metab 32:1659-76. 2012
  2. ncbi International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial
    Andrew Molyneux
    ISAT, Neurovascular Research Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 360:1267-74. 2002
  3. ncbi Subarachnoid haemorrhage
    Jan van Gijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584CX Utrecht, Netherlands
    Lancet 369:306-18. 2007
  4. ncbi Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment
    David O Wiebers
    KA MZ, ISUIA Coordinating Center, Mayo Clinic, Rochester, MN 55905, USA
    Lancet 362:103-10. 2003
  5. ncbi Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils
    Jean Raymond
    Department of Radiology, Centre Hospitalier de l Universite de Montreal, Notre Dame Hospital, 1560 Sherbrooke East, Room M 8203 1, Montreal, Quebec, H2L 4M1, Canada
    Stroke 34:1398-403. 2003
  6. ncbi International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and
    Andrew J Molyneux
    Neurovascular Research Unit, Nuffield Department of Surgery, University of Oxford and Oxford Radcliffe Hospitals NHS Trust, Radcliffe Infirmary, Oxford, UK
    Lancet 366:809-17. 2005
  7. ncbi Remodeling technique for endovascular treatment of ruptured intracranial aneurysms had a higher rate of adequate postoperative occlusion than did conventional coil embolization with comparable safety
    Laurent Pierot
    Department of Neuroradiology, Reims University, Hopital Maison Blanche, 45 rue Cognacq Jay, 51092 Reims, France
    Radiology 258:546-53. 2011
  8. pmc Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends
    N K de Rooij
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 78:1365-72. 2007
  9. ncbi Treatment of intracranial aneurysms by functional reconstruction of the parent artery: the Budapest experience with the pipeline embolization device
    I Szikora
    Department of Neuroradiology, National Institute of Neurosurgery, Amerikai ut 57, Budapest, Hungary
    AJNR Am J Neuroradiol 31:1139-47. 2010
  10. ncbi Neuroform stent-assisted coil embolization of wide-neck intracranial aneurysms: strategies in stent deployment and midterm follow-up
    Alessandra Biondi
    Division of Interventional Neuroradiology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Neurosurgery 61:460-8; discussion 468-9. 2007

Detail Information

Publications307 found, 100 shown here

  1. pmc Biology of intracranial aneurysms: role of inflammation
    Nohra Chalouhi
    Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    J Cereb Blood Flow Metab 32:1659-76. 2012
    ..b>Intracranial aneurysm formation and progression appear to result from endothelial dysfunction, a mounting inflammatory response, ..
  2. ncbi International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial
    Andrew Molyneux
    ISAT, Neurovascular Research Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Lancet 360:1267-74. 2002
    ..We undertook a randomised, multicentre trial to compare the safety and efficacy of endovascular coiling with standard neurosurgical clipping for such aneurysms judged to be suitable for both treatments...
  3. ncbi Subarachnoid haemorrhage
    Jan van Gijn
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584CX Utrecht, Netherlands
    Lancet 369:306-18. 2007
    ..Hydrocephalus might cause gradual obtundation in the first few hours or days; it can be treated by lumbar puncture or ventricular drainage, dependent on the site of obstruction...
  4. ncbi Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment
    David O Wiebers
    KA MZ, ISUIA Coordinating Center, Mayo Clinic, Rochester, MN 55905, USA
    Lancet 362:103-10. 2003
    ..Investigators from the International Study of Unruptured Intracranial Aneurysms aimed to assess the natural history of unruptured intracranial aneurysms and to measure the risk associated with their repair...
  5. ncbi Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils
    Jean Raymond
    Department of Radiology, Centre Hospitalier de l Universite de Montreal, Notre Dame Hospital, 1560 Sherbrooke East, Room M 8203 1, Montreal, Quebec, H2L 4M1, Canada
    Stroke 34:1398-403. 2003
    ..Our aim in this study was to assess the incidence and determining factors of angiographic recurrences after endovascular treatment of aneurysms...
  6. ncbi International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and
    Andrew J Molyneux
    Neurovascular Research Unit, Nuffield Department of Surgery, University of Oxford and Oxford Radcliffe Hospitals NHS Trust, Radcliffe Infirmary, Oxford, UK
    Lancet 366:809-17. 2005
    ..Here we present clinical outcomes 1 year after treatment...
  7. ncbi Remodeling technique for endovascular treatment of ruptured intracranial aneurysms had a higher rate of adequate postoperative occlusion than did conventional coil embolization with comparable safety
    Laurent Pierot
    Department of Neuroradiology, Reims University, Hopital Maison Blanche, 45 rue Cognacq Jay, 51092 Reims, France
    Radiology 258:546-53. 2011
    ....
  8. pmc Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends
    N K de Rooij
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 78:1365-72. 2007
    ..To update our 1996 review on the incidence of subarachnoid haemorrhage (SAH) and assess the relation of incidence with region, age, gender and time period...
  9. ncbi Treatment of intracranial aneurysms by functional reconstruction of the parent artery: the Budapest experience with the pipeline embolization device
    I Szikora
    Department of Neuroradiology, National Institute of Neurosurgery, Amerikai ut 57, Budapest, Hungary
    AJNR Am J Neuroradiol 31:1139-47. 2010
    ..The use of mesh tubes has recently gained traction as an alternative therapy. This article summarizes the midterm results of using an endoluminal sleeve, the PED, in the treatment of aneurysms...
  10. ncbi Neuroform stent-assisted coil embolization of wide-neck intracranial aneurysms: strategies in stent deployment and midterm follow-up
    Alessandra Biondi
    Division of Interventional Neuroradiology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Neurosurgery 61:460-8; discussion 468-9. 2007
    ..To evaluate the midterm results of intracranial stent-assisted coil embolization in the treatment of wide-necked cerebral aneurysms and to assess the efficacy of various strategies used in stent deployment...
  11. ncbi Endovascular treatment of unruptured aneurysms
    D Roy
    Department of Radiology, University of Montreal, Quebec, Canada
    Stroke 32:1998-2004. 2001
    ..We sought to better define the morbidity of endovascular Guglielmi detachable coil (GDC) treatment of unruptured cerebral aneurysms and to discuss its role in the prevention of subarachnoid hemorrhage...
  12. pmc Cellular and molecular responses of the basilar terminus to hemodynamics during intracranial aneurysm initiation in a rabbit model
    John Kolega
    Toshiba Stroke Research Center, State University of New York at Buffalo, Buffalo, NY 14214, USA
    J Vasc Res 48:429-42. 2011
    ..We examined early cellular responses at rabbit basilar termini exposed to hemodynamic insult that initiates aneurysmal remodeling...
  13. ncbi Aneurysm inflow-angle as a discriminant for rupture in sidewall cerebral aneurysms: morphometric and computational fluid dynamic analysis
    Merih I Baharoglu
    Cerebrovascular and Endovascular Division, Department of Neurosurgery, Tufts Medical Center and Tufts University School of Medicine, Boston, Mass 02111, USA
    Stroke 41:1423-30. 2010
    ..The objective was to evaluate the importance of inflow-angle (IA), the angle separating parent vessel and aneurysm dome main axes...
  14. ncbi Saccular intracranial aneurysm: pathology and mechanisms
    Juhana Frösen
    Department of Neurosurgery, Helsinki University Central Hospital, Topeliuksenkatu 5, 00260 Helsinki, Finland
    Acta Neuropathol 123:773-86. 2012
    ..This may start the processes that eventually can lead to the decellularized and degenerated sIA wall that is prone to rupture...
  15. ncbi Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA
    Siew Kee Low
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Hum Mol Genet 21:2102-10. 2012
    ..Genetic factors have been known to play an important role in the development of intracranial aneurysm (IA), some of which further progress to subarachnoid hemorrhage (SAH)...
  16. pmc Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up
    Andrew J Molyneux
    Neurovascular Research Unit, Nuffield Department of Surgery, University of Oxford and Oxford Radcliffe Hospitals NHS Trust, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 8:427-33. 2009
    ..long-term risks of death, disability, and rebleeding in patients randomly assigned to clipping or endovascular coiling after rupture of an intracranial aneurysm in the follow-up of the International Subarachnoid Aneurysm Trial (ISAT).
  17. ncbi A new endoluminal, flow-disrupting device for treatment of saccular aneurysms
    David F Kallmes
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
    Stroke 38:2346-52. 2007
    ....
  18. ncbi Endovascular occlusion of wide-necked aneurysms with a new intracranial microstent (Neuroform) and detachable coils
    Ronald P Benitez
    Department of Neurosurgery, Thomas Jefferson University School of Medicine, Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    Neurosurgery 54:1359-67; discussion 1368. 2004
    ..We report the use of a new intracranial stent--the Neuroform microstent--in the treatment of patients with wide-necked cerebral aneurysms...
  19. ncbi Subarachnoid haemorrhage: diagnosis, causes and management
    J van Gijn
    Department of Neurology, University Medical Centre, Utrecht, The Netherlands
    Brain 124:249-78. 2001
    ..Once ischaemia has occurred, treatment regimens such as a combination of induced hypertension and hypervolaemia, or transluminal angioplasty, are plausible, but of unproven benefit...
  20. ncbi Neuroform in-stent stenosis: incidence, natural history, and treatment strategies
    David Fiorella
    Department of Neuroradiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neurosurgery 59:34-42; discussion 34-42. 2006
    ..The current series describes the incidence and natural history of in-stent stenosis after the deployment of the Neuroform stent within the cerebrovasculature for the treatment of aneurysms...
  21. ncbi Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis
    Monique Hm Vlak
    Utrecht Stroke Centre, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet Neurol 10:626-36. 2011
    ..Unruptured intracranial aneurysms (UIAs) are increasingly detected and are an important health-care burden. We aimed to assess the prevalence of UIAs according to family history, comorbidity, sex, age, country, and time period...
  22. ncbi Coiling of intracranial aneurysms: a systematic review on initial occlusion and reopening and retreatment rates
    Sandra P Ferns
    Department of Radiology, Academic Medical Center Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Stroke 40:e523-9. 2009
    ..To assess overall outcome of coiling, we systematically reviewed the literature to determine initial occlusion, reopening, and retreatment rates of coiled aneurysms according to predefined criteria and subgroups...
  23. ncbi Curative reconstruction of a giant midbasilar trunk aneurysm with the pipeline embolization device
    David Fiorella
    Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Neurosurgery 64:212-7; discussion 217. 2009
    ..To demonstrate the curative reconstruction of a giant circumferential basilar trunk aneurysm using the Pipeline embolization device (PED) (Chestnut Medical Technologies, Inc., Menlo Park, CA) alone, without embolization coils...
  24. ncbi Safety and efficacy of adjunctive balloon remodeling during endovascular treatment of intracranial aneurysms: a literature review
    M Shapiro
    Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA
    AJNR Am J Neuroradiol 29:1777-81. 2008
    ..Nevertheless, there exists concern that adjunctive use of balloon assistance may lead to increased adverse events during aneurysm coiling...
  25. ncbi Preliminary experience using the Neuroform stent for the treatment of cerebral aneurysms
    David Fiorella
    Department of Neuroradiology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Neurosurgery 54:6-16; discussion 16-7. 2004
    ....
  26. pmc Critical roles of macrophages in the formation of intracranial aneurysm
    Yasuhisa Kanematsu
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Stroke 42:173-8. 2011
    ..Using a mouse model of intracranial aneurysms, we tested whether macrophages play critical roles in the formation of intracranial aneurysms...
  27. pmc Morphology parameters for intracranial aneurysm rupture risk assessment
    Sujan Dhar
    Department of Mechanical and Aerospace Engineering, State University of New York, University at Buffalo, Buffalo, New York 14214, USA
    Neurosurgery 63:185-96; discussion 196-7. 2008
    The aim of this study is to identify image-based morphological parameters that correlate with human intracranial aneurysm (IA) rupture.
  28. ncbi Stent-assisted coiling of intracranial aneurysms: clinical and angiographic results in 216 consecutive aneurysms
    Michel Piotin
    Service de Neuroradiologie Interventionnelle et Fonctionnelle, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild, 25 29 Rue Manin 75940 Paris, Cedex 19, France
    Stroke 41:110-5. 2010
    ..We present our experience with stent-assisted coiling with special emphasis on procedure-related neurological complications and incidence of angiographic recurrence...
  29. pmc The development and the use of experimental animal models to study the underlying mechanisms of CA formation
    Tomohiro Aoki
    Department of Neurosurgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8501, Japan
    J Biomed Biotechnol 2011:535921. 2011
    ..Findings from animal studies have provided new insights into CA formation and may contribute to the development of new therapeutic drugs for CAs...
  30. ncbi Size ratio correlates with intracranial aneurysm rupture status: a prospective study
    Maryam Rahman
    University of Florida, Box 100265, Department of Neurosurgery, Gainesville, FL 32610, USA
    Stroke 41:916-20. 2010
    The prediction of intracranial aneurysm (IA) rupture risk has generated significant controversy...
  31. ncbi Differences in simple morphological variables in ruptured and unruptured middle cerebral artery aneurysms
    Ning Lin
    Department of Neurosurgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosurg 117:913-9. 2012
    ..The authors present a large sample of middle cerebral artery (MCA) aneurysms that were assessed using morphological variables to determine the parameters associated with aneurysm rupture...
  32. ncbi Stent-assisted coiling in acutely ruptured intracranial aneurysms: a qualitative, systematic review of the literature
    K D Bodily
    Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA
    AJNR Am J Neuroradiol 32:1232-6. 2011
    ..Our aim was to review the literature regarding stent-assisted coil embolization of acutely ruptured intracranial aneurysms to determine the safety and efficacy of this treatment option...
  33. ncbi Long-term follow-up of cerebral aneurysms after endovascular therapy prediction and outcome of retreatment
    T Ries
    Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    AJNR Am J Neuroradiol 28:1755-61. 2007
    ....
  34. ncbi Wide-necked intracranial aneurysms: treatment with stent-assisted coil embolization during acute (<72 hours) subarachnoid hemorrhage--experience in 61 consecutive patients
    Olli I Tähtinen
    Department of Diagnostic Radiology, Tampere University Hospital, 33521 Tampere, Finland
    Radiology 253:199-208. 2009
    ..To evaluate the safety and efficacy of stent-assisted embolization of ruptured wide-necked intracranial aneurysms during acute subarachnoid hemorrhage (SAH)...
  35. ncbi Acute subarachnoid hemorrhage: using 64-slice multidetector CT angiography to "triage" patients' treatment
    R Agid
    Division of Neuroradiology, Department of Medical Imaging, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario, M5T 2S8, Canada
    Neuroradiology 48:787-94. 2006
    ..To evaluate the clinical role of CT angiography (CTA) in patients with acute subarachnoid hemorrhage (SAH) for treatment decision-making...
  36. ncbi Stent-assisted embolization of wide-neck anterior communicating artery aneurysms: review of 21 consecutive cases
    Q Huang
    Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Changhai Road 168, Shanghai, China
    AJNR Am J Neuroradiol 30:1502-6. 2009
    ..We report our experience with stent-assisted embolization for wide-neck AcomA aneurysms in 21 patients. Particular attention is given to the morphologic characteristics and strategy of stent deployment...
  37. ncbi Size and location of ruptured and unruptured intracranial aneurysms measured by 3-dimensional rotational angiography
    Jürgen Beck
    Department of Neurosurgery, Johann Wolfgang Goethe University, 60528 Frankfurt am Main, Germany
    Surg Neurol 65:18-25; discussion 25-7. 2006
    ....
  38. ncbi Prevalence and risk of rupture of intracranial aneurysms: a systematic review
    G J Rinkel
    University Department of Neurology Utrecht, The Netherlands
    Stroke 29:251-6. 1998
    ..We conducted a systematic review on prevalence and risk of rupture of intracranial aneurysms and classified the data according to study design, study population, and aneurysm characteristics...
  39. ncbi Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases
    Juhana Frösen
    Neurosurgery Research Group, Biomedicum Helsinki, Helsinki, Finland
    Stroke 35:2287-93. 2004
    ..The cellular mechanisms of degeneration and repair preceding rupture of the saccular cerebral artery aneurysm wall need to be elucidated for rational design of growth factor or drug-releasing endovascular devices...
  40. ncbi Prevalence of symptomatic intracranial aneurysm and ischaemic stroke in pseudoxanthoma elasticum
    J S van den Berg
    Department of Neurology, University Hospital Nijmegen, The
    Cerebrovasc Dis 10:315-9. 2000
    ..The purpose of this study was to investigate the prevalence of symptomatic intracranial aneurysms (IAs) and ischaemic stroke (IS) in PXE...
  41. ncbi Mild intraoperative hypothermia during surgery for intracranial aneurysm
    Michael M Todd
    Department of Anesthesia, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    N Engl J Med 352:135-45. 2005
    Surgery for intracranial aneurysm often results in postoperative neurologic deficits...
  42. ncbi Curative endovascular reconstruction of cerebral aneurysms with the pipeline embolization device: the Buenos Aires experience
    Pedro Lylyk
    Departments of Neurosurgery and Interventional Neuroradiology, Clinica Sagrada Familia, Buenos Aires, Argentina
    Neurosurgery 64:632-42; discussion 642-3; quiz N6. 2009
    ..We present our initial periprocedural experience with the PED and midterm follow-up results for a series of 53 patients...
  43. ncbi Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivity
    Juan R Cebral
    School of Computational Sciences, George Mason University, 4400 University Drive, MSN 4C7, Fairfax, VA 22030, USA
    IEEE Trans Med Imaging 24:457-67. 2005
    ..We conclude that with the proposed modeling pipeline clinical studies involving large numbers cerebral aneurysms are feasible...
  44. ncbi Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats
    Tomohiro Aoki
    Kyoto University, Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto, Japan
    Stroke 38:162-9. 2007
    ..Matrix metalloproteinases (MMPs) are a family of proteinases which are involved in the remodeling of vascular walls. In the present study, we investigated the significance of MMPs in the progression of cerebral aneurysms...
  45. ncbi Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation
    Tomohiro Aoki
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Stroke 40:942-51. 2009
    ..Macrophages accumulate in CA walls and express proinflammatory genes promoting CA progression, but the molecular mechanisms of monocyte/macrophage recruitment into CA walls remain to be elucidated...
  46. ncbi NF-kappaB is a key mediator of cerebral aneurysm formation
    Tomohiro Aoki
    Department of Neurosurgery, Kyoto University, Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Circulation 116:2830-40. 2007
    ..We examined the role of nuclear factor-kappaB (NF-kappaB) in the pathogenesis of CA formation in this study...
  47. ncbi A comparison of functional and physical properties of self-expanding intracranial stents [Neuroform3, Wingspan, Solitaire, Leo+, Enterprise]
    O Krischek
    Klinik für Neuroradiologie, Klinikum Stuttgart, Stuttgart, Germany
    Minim Invasive Neurosurg 54:21-8. 2011
    ....
  48. ncbi Endovascular occlusion of intracranial wide-necked aneurysms with stenting (Neuroform) and coiling: mid-term and long-term results
    Jacques Sedat
    Unité de Neurointerventionnelle, Hopital St Roch, CHU Nice, 5 rue Pierre Devoluy, Nice, 06000, France
    Neuroradiology 51:401-9. 2009
    ..The purpose of this report is to present our experience with the Neuroform Stent associated with coiling and to evaluate complications, effectiveness, and long-term results of this technique...
  49. ncbi Opinion: imaging follow-up after coiling of intracranial aneurysms
    W J van Rooij
    Department of Radiology, St Elisabeth Ziekenhuis, Tilburg, The Netherlands
    AJNR Am J Neuroradiol 30:1646-8. 2009
    ....
  50. ncbi The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 40:217-24. 2008
    ..31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D...
  51. pmc Time-resolved 3D contrast-enhanced MRA on 3.0T: a non-invasive follow-up technique after stent-assisted coil embolization of the intracranial aneurysm
    Jin Woo Choi
    Department of Radiology, Konkuk University School of Medicine, Seoul 143 729, Korea
    Korean J Radiol 12:662-70. 2011
    ..To evaluate the usefulness of time-resolved contrast enhanced magnetic resonance angiography (4D MRA) after stent-assisted coil embolization by comparing it with time of flight (TOF)-MRA...
  52. pmc Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure
    Emília Ilona Gaál
    Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    PLoS Genet 8:e1002563. 2012
    ..Further, we demonstrate that common disease loci identified in a population isolate may bear wider significance...
  53. ncbi Systematic review of reviews of risk factors for intracranial aneurysms
    Mike Clarke
    UK Cochrane Centre, National Institute for Health Research, Middle Way, Oxford, OX2 7LG, UK
    Neuroradiology 50:653-64. 2008
    ..of systematic reviews performed to investigate factors that might influence the risk of rupture of an intracranial aneurysm. It exemplifies the technique of this type of research and reports the finding of a specific study...
  54. pmc Genome-wide association study of intracranial aneurysm identifies three new risk loci
    Katsuhito Yasuno
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Genet 42:420-5. 2010
    ..It is noteworthy that several putative risk genes play a role in cell-cycle progression, potentially affecting the proliferation and senescence of progenitor-cell populations that are responsible for vascular formation and repair...
  55. pmc Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results
    David Hasan
    Department of Neurosurgery, Carver College of Medicine, University of Iowa, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, JCP 1616, Iowa City, IA 52242, USA
    Stroke 43:1964-7. 2012
    ..The upregulation of COX-2/mPGES-1 in the wall of ruptured human cerebral aneurysms is not known...
  56. ncbi The detection and management of unruptured intracranial aneurysms
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Brain 123:205-21. 2000
    ..SAH, mostly due to rupture of an intracranial aneurysm, accounts for a quarter of cerebrovascular deaths...
  57. ncbi Progressive aneurysm development following hemodynamic insult
    Hui Meng
    Departments of Mechanical and Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14214, USA
    J Neurosurg 114:1095-103. 2011
    Hemodynamic insult has been speculated to be a key factor in intracranial aneurysm formation; however, it is unclear whether a sustained insult is necessary...
  58. ncbi Prehemorrhage risk factors for fatal intracranial aneurysm rupture
    Seppo Juvela
    Department of Neurosurgery, Helsinki University Central Hospital, Topeliuksenkatu 5, FIN 00260 Helsinki 26, Finland
    Stroke 34:1852-7. 2003
    ....
  59. ncbi Comparative morphological analysis of the geometry of ruptured and unruptured aneurysms
    Aichi Chien
    Division of Interventional Neuroradiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Neurosurgery 69:349-56. 2011
    ..The risk of aneurysm rupture appears to be related to multiple factors such as topology, morphology, size, perianeurysmal environment, and blood flow hemodynamics...
  60. ncbi Stent-supported aneurysm coiling: a literature survey of treatment and follow-up
    M Shapiro
    Bernard and Irene Schwartz Neurointerventional Radiology Center, Department of Radiology, NYU Langone Medical Center, New York, USA
    AJNR Am J Neuroradiol 33:159-63. 2012
    ..A sizable body of literature describing various experiences with stent-supported coiling now exists. The purpose of this research was to carry out a comprehensive literature survey of stent-supported aneurysm coiling...
  61. pmc Influence of intracranial aneurysm-to-parent vessel size ratio on hemodynamics and implication for rupture: results from a virtual experimental study
    Markus Tremmel
    Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA
    Neurosurgery 64:622-30; discussion 630-1. 2009
    The effectiveness of intracranial aneurysm (IA) size as a predictor for rupture has been debated...
  62. ncbi Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms
    Koichi Akiyama
    Department of Molecular Life Sciences, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Hum Genet 55:656-61. 2010
    An intracranial aneurysm (IA), which results in a subarachnoid hemorrhage with a high mortality on rupture, is a major public health concern...
  63. ncbi Analysis by categorizing or dichotomizing continuous variables is inadvisable: an example from the natural history of unruptured aneurysms
    O Naggara
    Department of Radiology, Interventional Neuroradiology Research Unit, International Consortium of Neuroendovascular Centres, University of Montreal, CHUM Notre Dame Hospital, Quebec, Canada
    AJNR Am J Neuroradiol 32:437-40. 2011
    ..Categorization of continuous data, especially dichotomization, is unnecessary for statistical analysis. Continuous explanatory variables should be left alone in statistical models...
  64. ncbi Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms
    Masaaki Shojima
    Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan
    Stroke 35:2500-5. 2004
    ..The magnitude and distribution of the WSS in and around human middle cerebral artery (MCA) aneurysms were analyzed using the method of computed fluid dynamics (CFD)...
  65. ncbi Stent-assisted coiling of intracranial aneurysms: predictors of complications, recanalization, and outcome in 508 cases
    Nohra Chalouhi
    Department of Neurological Surgery, Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Stroke 44:1348-53. 2013
    ..Self-expanding stents are increasingly used for treatment of complex intracranial aneurysms. We assess the safety and the efficacy of intracranial stenting and determine predictors of treatment outcomes...
  66. ncbi Aneurysm treatment in Europe 2010: an internet survey
    Ondrej Bradác
    Department of Neurosurgery, Central Military Hospital and Charles University, Prague, Czech Republic
    Acta Neurochir (Wien) 154:971-8; discussion 977-8. 2012
    ..Therefore we decided to conduct a survey in order to better understand the "state of the art" in aneurysm treatment in Europe. The primary aim was to understand the roles of clipping and coiling in aneurysm treatment...
  67. ncbi Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia-inducible factor-1A, and ETS transcription factors
    Mitja I Kurki
    Laboratory of Functional Genomics and Bioinformatics, Department of Neurobiology, A I Virtanen Institute, University of Eastern Finland, Kuopio, Finland
    Neurosurgery 68:1667-75; discussion 1675-6. 2011
    Aneurysmal subarachnoid hemorrhage, almost always from saccular intracranial aneurysm (sIA), is a devastating form of stroke that affects the working-age population...
  68. pmc Hemodynamic-morphologic discriminants for intracranial aneurysm rupture
    Jianping Xiang
    Toshiba Stroke Research Center, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Stroke 42:144-52. 2011
    the purpose of this study was to identify significant morphological and hemodynamic parameters that discriminate intracranial aneurysm rupture status using 3-dimensional angiography and computational fluid dynamics.
  69. ncbi The influence of genetics on intracranial aneurysm formation and rupture: current knowledge and its possible impact on future treatment
    B Krischek
    Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
    Adv Tech Stand Neurosurg 33:131-47. 2008
    The etiology of intracranial aneurysm formation and rupture remains mostly unknown, but lately several studies have increasingly supported the role of genetic factors...
  70. ncbi Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models
    Juan R Cebral
    Department of Radiology, Inova Fairfax Hospital, Falls Church, VA 22042, USA
    AJNR Am J Neuroradiol 26:2550-9. 2005
    ..This report describes a pilot clinical study of the association between intra-aneurysmal hemodynamic characteristics from computational fluid dynamic models and the rupture of cerebral aneurysms...
  71. pmc Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture
    David M Hasan
    Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, USA
    Stroke 42:3156-62. 2011
    Chronic inflammation is postulated as an important phenomenon in intracranial aneurysm wall pathophysiology. This study was conducted to determine if aspirin use impacts the occurrence of intracranial aneurysm rupture.
  72. pmc PGE(2) -EP(2) signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB
    T Aoki
    Department of Neurosurgery Kyoto University Graduate School of Medicine, Kyoto, Japan
    Br J Pharmacol 163:1237-49. 2011
    ....
  73. ncbi Three-dimensional volume-rendering technique in the angiographic follow-up of intracranial aneurysms embolized with coils
    Bing Zhou
    Department of Diagnostic and Interventional Radiology, Shanghai Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    J Neurosurg 112:674-80. 2010
    ..The authors conducted a study to evaluate the advantages of a 3D volume-rendering technique (VRT) in follow-up digital subtraction (DS) angiography of coil-embolized intracranial aneurysms...
  74. ncbi Expression of structural proteins and angiogenic factors in normal arterial and unruptured and ruptured aneurysm walls
    Turker Kilic
    Department of Neurosurgery, Marmara University, and Laboratory of Molecular Neurosurgery, Institute of Neurological Sciences, Istanbul, Turkey
    Neurosurgery 57:997-1007; discussion 997-1007. 2005
    ..proteins and angiogenic growth factors in vessel tissues that represent different phases of the process of intracranial aneurysm formation and rupture: normal vessel wall, intact (unruptured) aneurysm wall, and ruptured vessel wall.
  75. ncbi Endovascular treatment of intracranial aneurysms with a branch arising from the sac
    B Lubicz
    Department of Neuroradiology, Erasme University Hospital, Brussels, Belgium
    AJNR Am J Neuroradiol 27:142-7. 2006
    ..Saccular aneurysms with a branch arising from the sac, however, are mostly candidates for surgery rather than embolization. We prospectively evaluated the feasibility and safety of the EVT in such cases...
  76. ncbi Long-term follow-up after treatment of intracranial aneurysms with the Pipeline embolization device: results from a single center
    H A Deutschmann
    Department of Radiology, Medical University Graz, Graz, Austria
    AJNR Am J Neuroradiol 33:481-6. 2012
    ..The purpose of our research was to report the long-term angiographic and cross-sectional imaging results after placement of a PED in 12 patients with wide-neck intracranial aneurysms...
  77. pmc Pipeline embolization device (PED) for neurovascular reconstruction: initial experience in the treatment of 101 intracranial aneurysms and dissections
    Sebastian Fischer
    Neuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Stuttgart, Germany
    Neuroradiology 54:369-82. 2012
    ..The purpose of this study was to evaluate the safety and efficacy of the recently available flow diverter "pipeline embolization device" (PED) for the treatment of intracranial aneurysms and dissections...
  78. ncbi Endovascular treatment of wide-neck intracranial aneurysms using a microcatheter protective technique: results and outcomes in 75 aneurysms
    J Y Lee
    Department of Radiology, Seoul National University College of Medicine, Korea
    AJNR Am J Neuroradiol 32:917-22. 2011
    ..The purpose of this study was to describe this method and to evaluate its efficacy and safety as an alternative to a multiple-microcatheter or balloon- or stent-assisted technique for wide-neck aneurysms...
  79. ncbi Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatment
    J R Cebral
    Center for Computational Fluid Dynamics, George Mason University, Fairfax, Virginia 22030, USA
    AJNR Am J Neuroradiol 32:27-33. 2011
    Flow-diverting approaches to intracranial aneurysm treatment had many promising early results, but recent apparently successful treatments have been complicated by later aneurysm hemorrhage...
  80. pmc Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk
    Katsuhito Yasuno
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 108:19707-12. 2011
    The pathogenesis of intracranial aneurysm (IA) formation and rupture is complex, with significant contribution from genetic factors...
  81. ncbi Risk of ventriculostomy-related hemorrhage in patients with acutely ruptured aneurysms treated using stent-assisted coiling
    David K Kung
    Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    J Neurosurg 114:1021-7. 2011
    ..The aim of this study was to directly quantify the risk of ventriculostomy-related hemorrhage in patients with acute aneurysmal subarachnoid hemorrhage treated with stent-assisted coiling...
  82. pmc Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study
    Loic Boussel
    Department of Radiology, VA Medical Center, San Francisco, USA 94121, USA
    Stroke 39:2997-3002. 2008
    ..Low wall shear stress (WSS) has been reported to have a negative effect on endothelial cells normal physiology and may be an important contributor to local remodeling of the arterial wall and to aneurysm growth and rupture...
  83. ncbi Thromboembolic complications of elective coil embolization of unruptured aneurysms: the effect of oral antiplatelet preparation on periprocedural thromboembolic complication
    Gyojun Hwang
    Department of Neurosurgery, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, Korea
    Neurosurgery 67:743-8; discussion 748. 2010
    ..We retrospectively evaluated whether antiplatelet preparation lowered the thromboembolic complication rate during the perioperative period...
  84. ncbi Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysms
    J Caird
    Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland
    Eur J Neurol 13:1098-105. 2006
    ..specimens of non-atherosclerotic intracranial aneurysms, because of the relative unavailability of fresh intracranial aneurysm tissue (i.e. reluctance to excise the aneurysm fundus at surgery)...
  85. ncbi Gene expression profiles in human ruptured and unruptured intracranial aneurysms: what is the role of inflammation?
    Joanna Pera
    Department of Neurology, Jagiellonian University, Krakow, Poland
    Stroke 41:224-31. 2010
    ..The majority of studies on human tissue have focused on predefined pathways. We sought to analyze global gene expression patterns of ruptured IA, unruptured IA, and control vessels...
  86. ncbi Assessment of flow in perforating arteries during intracranial aneurysm surgery using intraoperative near-infrared indocyanine green videoangiography
    Jean G de Oliveira
    Department of Neurosurgery, Neurocenter, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurgery 61:63-72; discussion 72-3. 2007
    ..In addition, we analyzed the incidence of perforating vessels involved during the aneurysm surgery and the incidence of ischemic infarct caused by compromised small arteries...
  87. ncbi Incidental intracranial aneurysms: rationale for treatment
    Jean Raymond
    Interventional Neuroradiology Research Unit, Department of Radiology, Centre Hospitalier de l Universite de Montreal, Notre Dame Hospital, Montreal, Canada
    Curr Opin Neurol 22:96-102. 2009
    ..The review critically appraises the available evidence and current rationale for treating incidental intracranial aneurysms...
  88. ncbi Horizontal stent-assisted coil embolisation of wide-necked intracranial aneurysms with the Enterprise stent--a case series with early angiographic follow-up
    Mohammed Aslam Siddiqui
    Department of Neuroradiology, Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK
    Neuroradiology 51:411-8. 2009
    ..The purpose of the study is to describe our experience in eight cases of horizontal stenting across the circle of Willis in patients with terminal aneurysms...
  89. ncbi Complement activation associates with saccular cerebral artery aneurysm wall degeneration and rupture
    Riikka Tulamo
    Neurosurgery Research Group, Room B408a2, Biomedicum Helsinki, P O Box 700, FI 00029 Huch, Finland
    Neurosurgery 59:1069-76; discussion 1076-7. 2006
    ..We studied how complement activation associates with SCAA wall degeneration and rupture to better understand the pathobiology of SCAA wall rupture...
  90. ncbi Sensitivity of noncontrast cranial computed tomography for the emergency department diagnosis of subarachnoid hemorrhage
    Richard L Byyny
    Department of Emergency Medicine, Denver Health Medical Center, Denver, CO, USA
    Ann Emerg Med 51:697-703. 2008
    ..The purpose of this study is to determine the sensitivity of noncontrast cranial CT in detecting all spontaneous subarachnoid hemorrhages and those caused by aneurysm or arteriovenous malformation...
  91. ncbi Stent reconstruction of wide-necked aneurysms across the circle of Willis
    Michael E Kelly
    Division of Cerebrovascular and Endovascular Neurosurgery, Department of Neurosurgery, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurosurgery 61:249-54; discussion 254-5. 2007
    ..To describe a novel technique for single stent reconstruction of wide-necked aneurysms arising from the circle of Willis...
  92. ncbi Treatment of intracranial aneurysms with the Enterprise stent: a multicenter registry
    J Mocco
    Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA
    J Neurosurg 110:35-9. 2009
    ..Recent Food and Drug Administration approval of the Enterprise Vascular Reconstruction Device and Delivery System (Cordis) has added a new option for self-expanding stent-assisted intracranial aneurysm coiling.
  93. ncbi Assessment of microscope-integrated indocyanine green angiography during intracranial aneurysm surgery: a retrospective study of 120 patients
    Jin Li
    Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guo Xue Xiang Street, Chengdu 610 041, China
    Neurol India 57:453-9. 2009
    The purpose of this study was to assess the clinical value of indocyanine green angiography (ICG) in intracranial aneurysm surgery by comparing the findings with postoperative angiographic results.
  94. ncbi The critical role of hemodynamics in the development of cerebral vascular disease
    Alexander M Nixon
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosurg 112:1240-53. 2010
    ..The recognition of WSS as an important factor in cerebral vascular disease may help to identify individuals at risk and guide treatment options...
  95. ncbi Intraoperative indocyanine green angiography in intracranial aneurysm surgery: Microsurgical clipping and revascularization
    Chi Yuan Ma
    Department of Neurosurery, Nanjing Jinling Hospital, Nanjing University, School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China
    Clin Neurol Neurosurg 111:840-6. 2009
    ..The goal of this report is to illustrate the use of intraoperative indocyanine green (ICG) angiography in the surgical management of intracranial aneurysms, including microsurgical clipping and revascularization...
  96. ncbi Early fatal hemorrhage after endovascular cerebral aneurysm treatment with a flow diverter (SILK-Stent): do we need to rethink our concepts?
    Bernd Turowski
    Institute of Radiology Neuroradiology, University of Duesseldorf, Duesseldorf, Germany
    Neuroradiology 53:37-41. 2011
    ..All available data were reviewed and beside hemodynamic factors instability of the intra-aneurysmal thrombus is discussed as a possible cofactor leading to this disastrous event...
  97. ncbi Coil embolization of anterior circulation aneurysms supported by the Solitaire AB Neurovascular Remodeling Device
    Joachim Klisch
    Department of Diagnostic and Interventional Radiology and Neuroradiology, Helios General Hospital Erfurt, Nordhauser Str 74, 99089, Erfurt, Germany
    Neuroradiology 52:349-59. 2010
    ..The purpose of the study is to evaluate patients with wide-necked or complex aneurysms of the anterior circulation who underwent Solitaire AB Neurovascular Remodeling Device-assisted coil embolization...
  98. ncbi Cerebral Aneurysm Multicenter European Onyx (CAMEO) trial: results of a prospective observational study in 20 European centers
    Andrew J Molyneux
    Neurovascular Research Unit, Radcliffe Infirmary, Oxford, UK
    AJNR Am J Neuroradiol 25:39-51. 2004
    ....
  99. ncbi Treatment of a wide-necked aneurysm of the anterior cerebral artery using two Enterprise stents in "Y"-configuration stenting technique and coil embolization: a technical note
    Stefan Rohde
    Department of Neuroradiology, University of Heidelberg Medical Centre, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
    Neuroradiology 52:231-5. 2010
    ..We report a 52-year-old woman with recurrence of a wide-necked aneurysm of the anterior cerebral artery that was successfully retreated by stent-assisted coiling using the "Y"-stenting technique with the Enterprise stent system...
  100. ncbi Endovascular coil embolization of very small intracranial aneurysms
    Jin Ho Hwang
    Department of Radiology, Konkuk University Medical Center, 4 12 Hwayang dong, Gwangjin gu, Seoul, 143 729, South Korea
    Neuroradiology 53:349-57. 2011
    ..We report clinical and angiographic results of coil embolization of these aneurysms...
  101. ncbi MR angiography at 3T versus digital subtraction angiography in the follow-up of intracranial aneurysms treated with detachable coils
    Charles B L M Majoie
    Department of Radiology, Academic Medical Center, University of Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 26:1349-56. 2005
    ..We assessed the feasibility and usefulness of 3D time-of-flight (TOF) MR angiography (MRA) performed at 3T compared with DSA for the follow-up of coil-treated intracranial aneurysms...

Research Grants54

  1. HYPOTHERMIA DURING INTRACRANIAL ANEURYSM SURGERY
    Michael Todd; Fiscal Year: 2003
    ..means of reducing early and long-term postoperative neurologic morbidity following surgery for clipping of intracranial aneurysm. Control patients will remain normothermic during and after surgery; in hypothermic patients, body ..
  2. The Role of Mast Cells in the Pathophysiology of Intracranial Aneurysm
    Tomoki Hashimoto; Fiscal Year: 2013
    ..We have developed a novel mouse model of intracranial aneurysm. In this model, spontaneous aneurysmal rupture occurs with a predictable time course...
  3. EVOLVING MECHANICS OF INTRALUMINAL THROMBUS: FROM FORMATION TO ORGANIZATION
    Jay D Humphrey; Fiscal Year: 2010
    ..cerebral vasospasm, the leading cause of morbidity and mortality in patients surviving the rupture of an intracranial aneurysm, correlates strongly with clot burden and clot clearance rates...
  4. Molecular Imaging to Determine the Risk of Rupture of Cerebral Aneurysms
    Alexei Bogdanov; Fiscal Year: 2009
    ..above, we hypothesize that some of the MPO-specific effects in plaque progression could also contribute to intracranial aneurysm instability...
  5. Cerebral Aneurysm Clipping Training Simulator using Virtual Reality and Haptics
    P Pat Banerjee; Fiscal Year: 2013
    ..We also modeled aneurysm clips in 3D. Phase II focuses on programming the simulator for craniotomy, dural opening, and aneurysm clipping, and on validation. ..
  6. Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling and Inflammation
    Tomoki Hashimoto; Fiscal Year: 2013
    ..Our preliminary data using a newly developed mouse model of intracranial aneurysm show that ovariectomy (surgical menopause) increased the incidence of intracranial aneurysms in female ..
  7. Molecular Variants that Determine Genetic Susceptibility to Intracranial Aneurysm
    Murat Gunel; Fiscal Year: 2013
    ..abstract_text> ..
  8. Constrictor / Mitogen Induced Remodeling of Cerebral Arterioles
    JAY HUMPHREY; Fiscal Year: 2009
    ..of patients presenting with a subarachnoid hemorrhage (SAH), the most common cause of which is a ruptured intracranial aneurysm. This delayed process has traditionally been associated with a short-term but marked reduction in the ..
  9. Determinants of Intracranial Aneurysm Growth
    David A Saloner; Fiscal Year: 2013
    ..That information will be used to guide clinicians as to what interventional treatments might be considered, and when they might best be implemented. ..
  10. A new parameter for prediction of intracranial aneurysm hemodynamics and risk of
    Iman Borazjani; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A new parameter for prediction of intracranial aneurysm hemodynamics and risk of rupture Summary Quantifying the likelihood of aneurysm rupture is a significant clinical goal...
  11. Hemodynamics in Intracranial Aneurysm Pathogenesis
    DANIEL MARCELO SFORZA; Fiscal Year: 2012
    ..This project will not only shed light into the underlying mechanisms governing aneurysm initiation, but also will guide the development of clinical tools for the evaluation and treatment of cerebral aneurysms. ..
  12. Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial Aneurysms
    Hui Meng; Fiscal Year: 2013
    Little is known about intracranial aneurysm (IA) formation. We submit that specific hemodynamic conditions, not evaluated in prior aneurysm models, are critical for IA formation...
  13. Elucidating cardiovascular phenotaypes employing genome editing of iPS cells
    ERIC JEFFREY TOPOL; Fiscal Year: 2013
    ..A genomic variant associated with CAD, myocardial infarction (Ml), abdominal aortic aneurysm, and intracranial aneurysm is found in a stretch of chr9p21 devoid of known genes...
  14. THE OPTIMAL MANAGEMENT OF CEREBRAL ANEURYSMS
    Joseph King; Fiscal Year: 2004
    ..of cerebral aneurysms implies that 2,000,000 to 10,000,000 adults in the United States may harbor an intracranial aneurysm. Each year 21,000 of these individuals suffer a subarachnoid hemorrhage, resulting in significant ..
  15. MAPPING INTRACRANIAL ANEURYSM SUSCEPTIBILITY LOCI
    Lisa Cannon Albright; Fiscal Year: 2001
    ..Little is known about susceptibility to intracranial aneurysm (IA), although it is well recognized that there is a familial component, likely to be genetic in origin...
  16. RANDOMIZED STUDY OF NICARDIPINE IN SAH
    Neal Kassell; Fiscal Year: 1992
    Approximately 28,000 individuals in North America have a subarachnoid hemorrhage from a ruptured intracranial aneurysm each year...
  17. New Polymer Cerebral Aneurysm Filler Device
    ROBERT BOOCK; Fiscal Year: 2001
    ..S. The incidence of an intracranial aneurysm in the general population has been estimated to be between 1.5% to 8%...
  18. New Polymer Cerebral Aneurysm Filler Device
    Jeffrey Lee; Fiscal Year: 2004
    ..S. The incidence of an intracranial aneurysm in the general population has been estimated to be between 1.5% to 8%...
  19. DNA LINKAGE ANALYSIS IN INTRACRANIAL ANEURYSM FAMILIES
    GERARDUS TROMP; Fiscal Year: 2001
    ....
  20. SUPPORT FOR CEREBROVASCULAR RESEARCH CENTER
    James Robertson; Fiscal Year: 1980
    ..To develop a model of spontaneously occurring intracranial aneurysm which is identifiable by arteriography and frequent in production...
  21. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2008
    ..abstract_text> ..
  22. Hemodynamic Intervention of Intracranial Aneurysms
    Hui Meng; Fiscal Year: 2008
    ..A multi-faceted plan is proposed to train in areas of translational neurovascular intervention, integrative cerebrovascular biology and medical imaging. ..
  23. Improved Animal Modeling of Saccular Aneurysms
    David F Kallmes; Fiscal Year: 2010
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  24. Genetic and Tissue Engineering for Aneurysms
    David Kallmes; Fiscal Year: 2004
    ..Successful implementation of this research program will advance the field of genetic and tissue engineering and will improve the care of patients harboring life-threatening cerebral aneurysms. ..
  25. Identification of Novel Biomarkers in HD
    Tatiana Foroud; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. GENES FOR ALCOHOLISM SUSCEPTIBILITY
    Tatiana Foroud; Fiscal Year: 2003
    ..These studies will result in more sophisticated genetic analyses of alcoholism related data, as well as the development of optimum sampling designs for more efficient gene identification. ..
  27. GENETIC ANALYSIS OF HIP FRAGILITY
    Tatiana M Foroud; Fiscal Year: 2010
    ..Our goal is to find genetic causes for bone weakening conditions like osteoporosis so better treatments can be developed. ..
  28. A Cross-Cultural Longitudinal Assessment of FASD (U24)
    Tatiana Foroud; Fiscal Year: 2005
    ..abstract_text> ..
  29. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana M Foroud; Fiscal Year: 2010
    ..2. Study the role of parkin mutations in Parkinson's disease. 3. Perform molecular studies to identify PD susceptibility genes. 4. Evaluate putative PD susceptibility genes in a case-control sample. ..
  30. PD GWAS Consortium
    Tatiana M Foroud; Fiscal Year: 2010
    ....
  31. Longitudinal Studies Among At-Risk HD Gene Carriers
    Tatiana Foroud; Fiscal Year: 2006
    ..abstract_text> ..
  32. Familial Intracranial Aneurysm Study II (FIA II)
    JOSEPH PAUL BRODERICK; Fiscal Year: 2010
    ..Our experienced collaborative and highly productive team of Familial Intracranial Aneurysm (FIA) Investigators at 27 original sites in North America, Australia and New Zealand accomplished and ..
  33. THE VALIDITY OF CE-MRA: A NUMERICAL AND PHANTOM STUDY
    Liang Der Jou; Fiscal Year: 2002
    ..It is anticipated that this project will provide improved tools for the understanding of Contrast-Enhanced MRA and will lead to more accurate and reliable methods for assessing vascular disease in vivo. ..
  34. THE VALIDITY OF CE-MRA: A NUMERICAL AND PHANTOM STUDY
    Liang Der Jou; Fiscal Year: 2003
    ..It is anticipated that this project will provide improved tools for the understanding of Contrast-Enhanced MRA and will lead to more accurate and reliable methods for assessing vascular disease in vivo. ..
  35. Interventional Management of Stroke III Planning Grant
    Joseph Broderick; Fiscal Year: 2004
    ..10. Explore funding of interventional angiography by CMS. 11. Continue interaction with industry, with attention to devices that might be applied to a device-augmented future IV/IA paradigm. ..
  36. Familial Aggregation of Stroke
    Daniel Woo; Fiscal Year: 2005
    ..Determining the component of the familial aggregation of ICH that is independent of the familial aggregation of environmental risk factors is a fundamental step in the analysis of the genetic epidemiology of stroke. ..
  37. Ex Vivo Delineation of Mechanisms of Cerebral Vasospasm
    JAY HUMPHREY; Fiscal Year: 2008
    ..In summary, we submit that this project will reveal new insight into mechanisms. ..
  38. Prednisone Ocular Myasthenia Gravis Trial Planning Grant
    Mark Kupersmith; Fiscal Year: 2004
    ....
  39. Novel Organ Culture & Theory for Arteriolar Remodeling
    JAY HUMPHREY; Fiscal Year: 2005
    ..We will collect simultaneous pressure-diameter, cell morphological, and actin cytoskeletal data at multiple times during the remodeling, which in turn will allow us to develop a novel, single theoretical framework. ..
  40. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2005
    ..Subsequent parallel studies will focus on additional pharmacological agents and gender-related differences. ..
  41. Quality of Life in Patients with Brain Metastases
    Joseph King; Fiscal Year: 2005
    ..abstract_text> ..
  42. Unruptured Intracranial Aneurysms: Neurologic Outcome
    Robert Brown; Fiscal Year: 2007
    ..abstract_text> ..
  43. OPTIMIZING MANAGEMENT OF TRANSIENT ISCHEMIC ATTACKS
    S Johnston; Fiscal Year: 2005
    ..This research will provide important results for clinicians and policy makers, and will foster the applicant's development as a health services researcher in cerebrovascular disease. ..
  44. In vivo multichannel fluorescent imaging
    Umar Mahmood; Fiscal Year: 2007
    ....
  45. Mechanical Stress and the Heat-Treatment of Soft Tissue
    JAY HUMPHREY; Fiscal Year: 2003
    ..There is a need for a firmer scientific understanding. ..
  46. RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODEL
    Michael Lawton; Fiscal Year: 2004
    ..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs. ..
  47. Siblings With Ischemic Stroke Study (SWISS)
    JAMES MESCHIA; Fiscal Year: 2009
    ..DNA banking and the creation of permanent lymphoblastoid cell lines will be done to permit future collaborative efforts to study the genetic basis for stroke risk. ..
  48. Study of design variables of the endovascular graft
    MADHAVAN RAGHAVAN; Fiscal Year: 2007
    ..Improvements in implant design will significantly improve post-operative quality of life for patients in the US and world-wide. [unreadable] [unreadable] [unreadable]..
  49. Cognitive Function After Intracranial Aneurysm Surgery
    Satwant Samra; Fiscal Year: 2005
    ..Information gained from this investigation will be important in giving a prognosis for returning back to work as well as planning rehabilitation of patients suffering from aneurysmal SAH in future. ..
  50. ISGS: The Ischemic Stroke Genetics Study
    JAMES MESCHIA; Fiscal Year: 2006
    ..The application and SWISS share the same definitions for the present and absence of phenotype and key enrollment criteria. ..
  51. ENDOTHELIAL DYSFUNCTION: FORMATION OF MICROPARTICLES
    Sergey Brodsky; Fiscal Year: 2005
    ..The proposed studies may provide novel information on the contribution of microparticles to the pathophysiology of endothelial cell dysfunction and coagulation abnormalities. ..
  52. POLARIZED LIGHT PROPAGATION AND IMAGING IN TISSUE
    Duncan Maitland; Fiscal Year: 2002
    ..At the conclusion of this work, the applicants anticipate being able to propose the construction and testing of a system for use in small animal imaging and pre-clinical trials for detection of tumors embedded in healthy tissue. ..