Genomes and Genes
Summary: Congenital or acquired abnormal outpouching of an intracranial blood vessel wall. Saccular (berry) aneurysms are the most common variant, and tend to form at arterial branch points near the base of the brain. Rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE (see also OCULOMOTOR NERVE DISEASES). (From Adams et al., Principles of Neurology, 6th ed, p841)
Publications307 found, 100 shown here
- Biology of intracranial aneurysms: role of inflammationNohra Chalouhi
Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
J Cereb Blood Flow Metab 32:1659-76. 2012..b>Intracranial aneurysm formation and progression appear to result from endothelial dysfunction, a mounting inflammatory response, ..
- International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trialAndrew Molyneux
ISAT, Neurovascular Research Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
Lancet 360:1267-74. 2002..We undertook a randomised, multicentre trial to compare the safety and efficacy of endovascular coiling with standard neurosurgical clipping for such aneurysms judged to be suitable for both treatments...
- Subarachnoid haemorrhageJan van Gijn
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, 3584CX Utrecht, Netherlands
Lancet 369:306-18. 2007..Hydrocephalus might cause gradual obtundation in the first few hours or days; it can be treated by lumbar puncture or ventricular drainage, dependent on the site of obstruction...
- Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatmentDavid O Wiebers
KA MZ, ISUIA Coordinating Center, Mayo Clinic, Rochester, MN 55905, USA
Lancet 362:103-10. 2003..Investigators from the International Study of Unruptured Intracranial Aneurysms aimed to assess the natural history of unruptured intracranial aneurysms and to measure the risk associated with their repair...
- Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coilsJean Raymond
Department of Radiology, Centre Hospitalier de l Universite de Montreal, Notre Dame Hospital, 1560 Sherbrooke East, Room M 8203 1, Montreal, Quebec, H2L 4M1, Canada
Stroke 34:1398-403. 2003..Our aim in this study was to assess the incidence and determining factors of angiographic recurrences after endovascular treatment of aneurysms...
- International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and Andrew J Molyneux
Neurovascular Research Unit, Nuffield Department of Surgery, University of Oxford and Oxford Radcliffe Hospitals NHS Trust, Radcliffe Infirmary, Oxford, UK
Lancet 366:809-17. 2005..Here we present clinical outcomes 1 year after treatment...
- Remodeling technique for endovascular treatment of ruptured intracranial aneurysms had a higher rate of adequate postoperative occlusion than did conventional coil embolization with comparable safetyLaurent Pierot
Department of Neuroradiology, Reims University, Hopital Maison Blanche, 45 rue Cognacq Jay, 51092 Reims, France
Radiology 258:546-53. 2011....
- Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trendsN K de Rooij
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
J Neurol Neurosurg Psychiatry 78:1365-72. 2007..To update our 1996 review on the incidence of subarachnoid haemorrhage (SAH) and assess the relation of incidence with region, age, gender and time period...
- Treatment of intracranial aneurysms by functional reconstruction of the parent artery: the Budapest experience with the pipeline embolization deviceI Szikora
Department of Neuroradiology, National Institute of Neurosurgery, Amerikai ut 57, Budapest, Hungary
AJNR Am J Neuroradiol 31:1139-47. 2010..The use of mesh tubes has recently gained traction as an alternative therapy. This article summarizes the midterm results of using an endoluminal sleeve, the PED, in the treatment of aneurysms...
- Neuroform stent-assisted coil embolization of wide-neck intracranial aneurysms: strategies in stent deployment and midterm follow-upAlessandra Biondi
Division of Interventional Neuroradiology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
Neurosurgery 61:460-8; discussion 468-9. 2007..To evaluate the midterm results of intracranial stent-assisted coil embolization in the treatment of wide-necked cerebral aneurysms and to assess the efficacy of various strategies used in stent deployment...
- Endovascular treatment of unruptured aneurysmsD Roy
Department of Radiology, University of Montreal, Quebec, Canada
Stroke 32:1998-2004. 2001..We sought to better define the morbidity of endovascular Guglielmi detachable coil (GDC) treatment of unruptured cerebral aneurysms and to discuss its role in the prevention of subarachnoid hemorrhage...
- Cellular and molecular responses of the basilar terminus to hemodynamics during intracranial aneurysm initiation in a rabbit modelJohn Kolega
Toshiba Stroke Research Center, State University of New York at Buffalo, Buffalo, NY 14214, USA
J Vasc Res 48:429-42. 2011..We examined early cellular responses at rabbit basilar termini exposed to hemodynamic insult that initiates aneurysmal remodeling...
- Aneurysm inflow-angle as a discriminant for rupture in sidewall cerebral aneurysms: morphometric and computational fluid dynamic analysisMerih I Baharoglu
Cerebrovascular and Endovascular Division, Department of Neurosurgery, Tufts Medical Center and Tufts University School of Medicine, Boston, Mass 02111, USA
Stroke 41:1423-30. 2010..The objective was to evaluate the importance of inflow-angle (IA), the angle separating parent vessel and aneurysm dome main axes...
- Saccular intracranial aneurysm: pathology and mechanismsJuhana Frösen
Department of Neurosurgery, Helsinki University Central Hospital, Topeliuksenkatu 5, 00260 Helsinki, Finland
Acta Neuropathol 123:773-86. 2012..This may start the processes that eventually can lead to the decellularized and degenerated sIA wall that is prone to rupture...
- Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRASiew Kee Low
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Hum Mol Genet 21:2102-10. 2012..Genetic factors have been known to play an important role in the development of intracranial aneurysm (IA), some of which further progress to subarachnoid hemorrhage (SAH)...
- Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-upAndrew J Molyneux
Neurovascular Research Unit, Nuffield Department of Surgery, University of Oxford and Oxford Radcliffe Hospitals NHS Trust, John Radcliffe Hospital, Oxford, UK
Lancet Neurol 8:427-33. 2009..long-term risks of death, disability, and rebleeding in patients randomly assigned to clipping or endovascular coiling after rupture of an intracranial aneurysm in the follow-up of the International Subarachnoid Aneurysm Trial (ISAT).
- A new endoluminal, flow-disrupting device for treatment of saccular aneurysmsDavid F Kallmes
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
Stroke 38:2346-52. 2007....
- Endovascular occlusion of wide-necked aneurysms with a new intracranial microstent (Neuroform) and detachable coilsRonald P Benitez
Department of Neurosurgery, Thomas Jefferson University School of Medicine, Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
Neurosurgery 54:1359-67; discussion 1368. 2004..We report the use of a new intracranial stent--the Neuroform microstent--in the treatment of patients with wide-necked cerebral aneurysms...
- Subarachnoid haemorrhage: diagnosis, causes and managementJ van Gijn
Department of Neurology, University Medical Centre, Utrecht, The Netherlands
Brain 124:249-78. 2001..Once ischaemia has occurred, treatment regimens such as a combination of induced hypertension and hypervolaemia, or transluminal angioplasty, are plausible, but of unproven benefit...
- Neuroform in-stent stenosis: incidence, natural history, and treatment strategiesDavid Fiorella
Department of Neuroradiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Neurosurgery 59:34-42; discussion 34-42. 2006..The current series describes the incidence and natural history of in-stent stenosis after the deployment of the Neuroform stent within the cerebrovasculature for the treatment of aneurysms...
- Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysisMonique Hm Vlak
Utrecht Stroke Centre, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, Netherlands
Lancet Neurol 10:626-36. 2011..Unruptured intracranial aneurysms (UIAs) are increasingly detected and are an important health-care burden. We aimed to assess the prevalence of UIAs according to family history, comorbidity, sex, age, country, and time period...
- Coiling of intracranial aneurysms: a systematic review on initial occlusion and reopening and retreatment ratesSandra P Ferns
Department of Radiology, Academic Medical Center Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Stroke 40:e523-9. 2009..To assess overall outcome of coiling, we systematically reviewed the literature to determine initial occlusion, reopening, and retreatment rates of coiled aneurysms according to predefined criteria and subgroups...
- Curative reconstruction of a giant midbasilar trunk aneurysm with the pipeline embolization deviceDavid Fiorella
Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
Neurosurgery 64:212-7; discussion 217. 2009..To demonstrate the curative reconstruction of a giant circumferential basilar trunk aneurysm using the Pipeline embolization device (PED) (Chestnut Medical Technologies, Inc., Menlo Park, CA) alone, without embolization coils...
- Safety and efficacy of adjunctive balloon remodeling during endovascular treatment of intracranial aneurysms: a literature reviewM Shapiro
Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA
AJNR Am J Neuroradiol 29:1777-81. 2008..Nevertheless, there exists concern that adjunctive use of balloon assistance may lead to increased adverse events during aneurysm coiling...
- Preliminary experience using the Neuroform stent for the treatment of cerebral aneurysmsDavid Fiorella
Department of Neuroradiology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
Neurosurgery 54:6-16; discussion 16-7. 2004....
- Critical roles of macrophages in the formation of intracranial aneurysmYasuhisa Kanematsu
Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
Stroke 42:173-8. 2011..Using a mouse model of intracranial aneurysms, we tested whether macrophages play critical roles in the formation of intracranial aneurysms...
- Morphology parameters for intracranial aneurysm rupture risk assessmentSujan Dhar
Department of Mechanical and Aerospace Engineering, State University of New York, University at Buffalo, Buffalo, New York 14214, USA
Neurosurgery 63:185-96; discussion 196-7. 2008The aim of this study is to identify image-based morphological parameters that correlate with human intracranial aneurysm (IA) rupture.
- Stent-assisted coiling of intracranial aneurysms: clinical and angiographic results in 216 consecutive aneurysmsMichel Piotin
Service de Neuroradiologie Interventionnelle et Fonctionnelle, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild, 25 29 Rue Manin 75940 Paris, Cedex 19, France
Stroke 41:110-5. 2010..We present our experience with stent-assisted coiling with special emphasis on procedure-related neurological complications and incidence of angiographic recurrence...
- The development and the use of experimental animal models to study the underlying mechanisms of CA formationTomohiro Aoki
Department of Neurosurgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8501, Japan
J Biomed Biotechnol 2011:535921. 2011..Findings from animal studies have provided new insights into CA formation and may contribute to the development of new therapeutic drugs for CAs...
- Size ratio correlates with intracranial aneurysm rupture status: a prospective studyMaryam Rahman
University of Florida, Box 100265, Department of Neurosurgery, Gainesville, FL 32610, USA
Stroke 41:916-20. 2010The prediction of intracranial aneurysm (IA) rupture risk has generated significant controversy...
- Differences in simple morphological variables in ruptured and unruptured middle cerebral artery aneurysmsNing Lin
Department of Neurosurgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Neurosurg 117:913-9. 2012..The authors present a large sample of middle cerebral artery (MCA) aneurysms that were assessed using morphological variables to determine the parameters associated with aneurysm rupture...
- Stent-assisted coiling in acutely ruptured intracranial aneurysms: a qualitative, systematic review of the literatureK D Bodily
Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA
AJNR Am J Neuroradiol 32:1232-6. 2011..Our aim was to review the literature regarding stent-assisted coil embolization of acutely ruptured intracranial aneurysms to determine the safety and efficacy of this treatment option...
- Long-term follow-up of cerebral aneurysms after endovascular therapy prediction and outcome of retreatmentT Ries
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
AJNR Am J Neuroradiol 28:1755-61. 2007....
- Wide-necked intracranial aneurysms: treatment with stent-assisted coil embolization during acute (<72 hours) subarachnoid hemorrhage--experience in 61 consecutive patientsOlli I Tähtinen
Department of Diagnostic Radiology, Tampere University Hospital, 33521 Tampere, Finland
Radiology 253:199-208. 2009..To evaluate the safety and efficacy of stent-assisted embolization of ruptured wide-necked intracranial aneurysms during acute subarachnoid hemorrhage (SAH)...
- Acute subarachnoid hemorrhage: using 64-slice multidetector CT angiography to "triage" patients' treatmentR Agid
Division of Neuroradiology, Department of Medical Imaging, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario, M5T 2S8, Canada
Neuroradiology 48:787-94. 2006..To evaluate the clinical role of CT angiography (CTA) in patients with acute subarachnoid hemorrhage (SAH) for treatment decision-making...
- Stent-assisted embolization of wide-neck anterior communicating artery aneurysms: review of 21 consecutive casesQ Huang
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Changhai Road 168, Shanghai, China
AJNR Am J Neuroradiol 30:1502-6. 2009..We report our experience with stent-assisted embolization for wide-neck AcomA aneurysms in 21 patients. Particular attention is given to the morphologic characteristics and strategy of stent deployment...
- Size and location of ruptured and unruptured intracranial aneurysms measured by 3-dimensional rotational angiographyJürgen Beck
Department of Neurosurgery, Johann Wolfgang Goethe University, 60528 Frankfurt am Main, Germany
Surg Neurol 65:18-25; discussion 25-7. 2006....
- Prevalence and risk of rupture of intracranial aneurysms: a systematic reviewG J Rinkel
University Department of Neurology Utrecht, The Netherlands
Stroke 29:251-6. 1998..We conducted a systematic review on prevalence and risk of rupture of intracranial aneurysms and classified the data according to study design, study population, and aneurysm characteristics...
- Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured casesJuhana Frösen
Neurosurgery Research Group, Biomedicum Helsinki, Helsinki, Finland
Stroke 35:2287-93. 2004..The cellular mechanisms of degeneration and repair preceding rupture of the saccular cerebral artery aneurysm wall need to be elucidated for rational design of growth factor or drug-releasing endovascular devices...
- Prevalence of symptomatic intracranial aneurysm and ischaemic stroke in pseudoxanthoma elasticumJ S van den Berg
Department of Neurology, University Hospital Nijmegen, The
Cerebrovasc Dis 10:315-9. 2000..The purpose of this study was to investigate the prevalence of symptomatic intracranial aneurysms (IAs) and ischaemic stroke (IS) in PXE...
- Mild intraoperative hypothermia during surgery for intracranial aneurysmMichael M Todd
Department of Anesthesia, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
N Engl J Med 352:135-45. 2005Surgery for intracranial aneurysm often results in postoperative neurologic deficits...
- Curative endovascular reconstruction of cerebral aneurysms with the pipeline embolization device: the Buenos Aires experiencePedro Lylyk
Departments of Neurosurgery and Interventional Neuroradiology, Clinica Sagrada Familia, Buenos Aires, Argentina
Neurosurgery 64:632-42; discussion 642-3; quiz N6. 2009..We present our initial periprocedural experience with the PED and midterm follow-up results for a series of 53 patients...
- Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivityJuan R Cebral
School of Computational Sciences, George Mason University, 4400 University Drive, MSN 4C7, Fairfax, VA 22030, USA
IEEE Trans Med Imaging 24:457-67. 2005..We conclude that with the proposed modeling pipeline clinical studies involving large numbers cerebral aneurysms are feasible...
- Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in ratsTomohiro Aoki
Kyoto University, Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto, Japan
Stroke 38:162-9. 2007..Matrix metalloproteinases (MMPs) are a family of proteinases which are involved in the remodeling of vascular walls. In the present study, we investigated the significance of MMPs in the progression of cerebral aneurysms...
- Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formationTomohiro Aoki
Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
Stroke 40:942-51. 2009..Macrophages accumulate in CA walls and express proinflammatory genes promoting CA progression, but the molecular mechanisms of monocyte/macrophage recruitment into CA walls remain to be elucidated...
- NF-kappaB is a key mediator of cerebral aneurysm formationTomohiro Aoki
Department of Neurosurgery, Kyoto University, Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
Circulation 116:2830-40. 2007..We examined the role of nuclear factor-kappaB (NF-kappaB) in the pathogenesis of CA formation in this study...
- A comparison of functional and physical properties of self-expanding intracranial stents [Neuroform3, Wingspan, Solitaire, Leo+, Enterprise]O Krischek
Klinik für Neuroradiologie, Klinikum Stuttgart, Stuttgart, Germany
Minim Invasive Neurosurg 54:21-8. 2011....
- Endovascular occlusion of intracranial wide-necked aneurysms with stenting (Neuroform) and coiling: mid-term and long-term resultsJacques Sedat
Unité de Neurointerventionnelle, Hopital St Roch, CHU Nice, 5 rue Pierre Devoluy, Nice, 06000, France
Neuroradiology 51:401-9. 2009..The purpose of this report is to present our experience with the Neuroform Stent associated with coiling and to evaluate complications, effectiveness, and long-term results of this technique...
- Opinion: imaging follow-up after coiling of intracranial aneurysmsW J van Rooij
Department of Radiology, St Elisabeth Ziekenhuis, Tilburg, The Netherlands
AJNR Am J Neuroradiol 30:1646-8. 2009....
- The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysmAnna Helgadottir
deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
Nat Genet 40:217-24. 2008..31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D...
- Time-resolved 3D contrast-enhanced MRA on 3.0T: a non-invasive follow-up technique after stent-assisted coil embolization of the intracranial aneurysmJin Woo Choi
Department of Radiology, Konkuk University School of Medicine, Seoul 143 729, Korea
Korean J Radiol 12:662-70. 2011..To evaluate the usefulness of time-resolved contrast enhanced magnetic resonance angiography (4D MRA) after stent-assisted coil embolization by comparing it with time of flight (TOF)-MRA...
- Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressureEmília Ilona Gaál
Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
PLoS Genet 8:e1002563. 2012..Further, we demonstrate that common disease loci identified in a population isolate may bear wider significance...
- Systematic review of reviews of risk factors for intracranial aneurysmsMike Clarke
UK Cochrane Centre, National Institute for Health Research, Middle Way, Oxford, OX2 7LG, UK
Neuroradiology 50:653-64. 2008..of systematic reviews performed to investigate factors that might influence the risk of rupture of an intracranial aneurysm. It exemplifies the technique of this type of research and reports the finding of a specific study...
- Genome-wide association study of intracranial aneurysm identifies three new risk lociKatsuhito Yasuno
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
Nat Genet 42:420-5. 2010..It is noteworthy that several putative risk genes play a role in cell-cycle progression, potentially affecting the proliferation and senescence of progenitor-cell populations that are responsible for vascular formation and repair...
- Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary resultsDavid Hasan
Department of Neurosurgery, Carver College of Medicine, University of Iowa, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, JCP 1616, Iowa City, IA 52242, USA
Stroke 43:1964-7. 2012..The upregulation of COX-2/mPGES-1 in the wall of ruptured human cerebral aneurysms is not known...
- The detection and management of unruptured intracranial aneurysmsJ M Wardlaw
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
Brain 123:205-21. 2000..SAH, mostly due to rupture of an intracranial aneurysm, accounts for a quarter of cerebrovascular deaths...
- Progressive aneurysm development following hemodynamic insultHui Meng
Departments of Mechanical and Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14214, USA
J Neurosurg 114:1095-103. 2011Hemodynamic insult has been speculated to be a key factor in intracranial aneurysm formation; however, it is unclear whether a sustained insult is necessary...
- Prehemorrhage risk factors for fatal intracranial aneurysm ruptureSeppo Juvela
Department of Neurosurgery, Helsinki University Central Hospital, Topeliuksenkatu 5, FIN 00260 Helsinki 26, Finland
Stroke 34:1852-7. 2003....
- Comparative morphological analysis of the geometry of ruptured and unruptured aneurysmsAichi Chien
Division of Interventional Neuroradiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Neurosurgery 69:349-56. 2011..The risk of aneurysm rupture appears to be related to multiple factors such as topology, morphology, size, perianeurysmal environment, and blood flow hemodynamics...
- Stent-supported aneurysm coiling: a literature survey of treatment and follow-upM Shapiro
Bernard and Irene Schwartz Neurointerventional Radiology Center, Department of Radiology, NYU Langone Medical Center, New York, USA
AJNR Am J Neuroradiol 33:159-63. 2012..A sizable body of literature describing various experiences with stent-supported coiling now exists. The purpose of this research was to carry out a comprehensive literature survey of stent-supported aneurysm coiling...
- Influence of intracranial aneurysm-to-parent vessel size ratio on hemodynamics and implication for rupture: results from a virtual experimental studyMarkus Tremmel
Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA
Neurosurgery 64:622-30; discussion 630-1. 2009The effectiveness of intracranial aneurysm (IA) size as a predictor for rupture has been debated...
- Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysmsKoichi Akiyama
Department of Molecular Life Sciences, Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa, Japan
J Hum Genet 55:656-61. 2010An intracranial aneurysm (IA), which results in a subarachnoid hemorrhage with a high mortality on rupture, is a major public health concern...
- Analysis by categorizing or dichotomizing continuous variables is inadvisable: an example from the natural history of unruptured aneurysmsO Naggara
Department of Radiology, Interventional Neuroradiology Research Unit, International Consortium of Neuroendovascular Centres, University of Montreal, CHUM Notre Dame Hospital, Quebec, Canada
AJNR Am J Neuroradiol 32:437-40. 2011..Categorization of continuous data, especially dichotomization, is unnecessary for statistical analysis. Continuous explanatory variables should be left alone in statistical models...
- Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysmsMasaaki Shojima
Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan
Stroke 35:2500-5. 2004..The magnitude and distribution of the WSS in and around human middle cerebral artery (MCA) aneurysms were analyzed using the method of computed fluid dynamics (CFD)...
- Stent-assisted coiling of intracranial aneurysms: predictors of complications, recanalization, and outcome in 508 casesNohra Chalouhi
Department of Neurological Surgery, Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Stroke 44:1348-53. 2013..Self-expanding stents are increasingly used for treatment of complex intracranial aneurysms. We assess the safety and the efficacy of intracranial stenting and determine predictors of treatment outcomes...
- Aneurysm treatment in Europe 2010: an internet surveyOndrej Bradác
Department of Neurosurgery, Central Military Hospital and Charles University, Prague, Czech Republic
Acta Neurochir (Wien) 154:971-8; discussion 977-8. 2012..Therefore we decided to conduct a survey in order to better understand the "state of the art" in aneurysm treatment in Europe. The primary aim was to understand the roles of clipping and coiling in aneurysm treatment...
- Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia-inducible factor-1A, and ETS transcription factorsMitja I Kurki
Laboratory of Functional Genomics and Bioinformatics, Department of Neurobiology, A I Virtanen Institute, University of Eastern Finland, Kuopio, Finland
Neurosurgery 68:1667-75; discussion 1675-6. 2011Aneurysmal subarachnoid hemorrhage, almost always from saccular intracranial aneurysm (sIA), is a devastating form of stroke that affects the working-age population...
- Hemodynamic-morphologic discriminants for intracranial aneurysm ruptureJianping Xiang
Toshiba Stroke Research Center, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
Stroke 42:144-52. 2011the purpose of this study was to identify significant morphological and hemodynamic parameters that discriminate intracranial aneurysm rupture status using 3-dimensional angiography and computational fluid dynamics.
- The influence of genetics on intracranial aneurysm formation and rupture: current knowledge and its possible impact on future treatmentB Krischek
Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
Adv Tech Stand Neurosurg 33:131-47. 2008The etiology of intracranial aneurysm formation and rupture remains mostly unknown, but lately several studies have increasingly supported the role of genetic factors...
- Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics modelsJuan R Cebral
Department of Radiology, Inova Fairfax Hospital, Falls Church, VA 22042, USA
AJNR Am J Neuroradiol 26:2550-9. 2005..This report describes a pilot clinical study of the association between intra-aneurysmal hemodynamic characteristics from computational fluid dynamic models and the rupture of cerebral aneurysms...
- Aspirin as a promising agent for decreasing incidence of cerebral aneurysm ruptureDavid M Hasan
Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, USA
Stroke 42:3156-62. 2011Chronic inflammation is postulated as an important phenomenon in intracranial aneurysm wall pathophysiology. This study was conducted to determine if aspirin use impacts the occurrence of intracranial aneurysm rupture.
- PGE(2) -EP(2) signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κBT Aoki
Department of Neurosurgery Kyoto University Graduate School of Medicine, Kyoto, Japan
Br J Pharmacol 163:1237-49. 2011....
- Three-dimensional volume-rendering technique in the angiographic follow-up of intracranial aneurysms embolized with coilsBing Zhou
Department of Diagnostic and Interventional Radiology, Shanghai Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai, China
J Neurosurg 112:674-80. 2010..The authors conducted a study to evaluate the advantages of a 3D volume-rendering technique (VRT) in follow-up digital subtraction (DS) angiography of coil-embolized intracranial aneurysms...
- Expression of structural proteins and angiogenic factors in normal arterial and unruptured and ruptured aneurysm wallsTurker Kilic
Department of Neurosurgery, Marmara University, and Laboratory of Molecular Neurosurgery, Institute of Neurological Sciences, Istanbul, Turkey
Neurosurgery 57:997-1007; discussion 997-1007. 2005..proteins and angiogenic growth factors in vessel tissues that represent different phases of the process of intracranial aneurysm formation and rupture: normal vessel wall, intact (unruptured) aneurysm wall, and ruptured vessel wall.
- Endovascular treatment of intracranial aneurysms with a branch arising from the sacB Lubicz
Department of Neuroradiology, Erasme University Hospital, Brussels, Belgium
AJNR Am J Neuroradiol 27:142-7. 2006..Saccular aneurysms with a branch arising from the sac, however, are mostly candidates for surgery rather than embolization. We prospectively evaluated the feasibility and safety of the EVT in such cases...
- Long-term follow-up after treatment of intracranial aneurysms with the Pipeline embolization device: results from a single centerH A Deutschmann
Department of Radiology, Medical University Graz, Graz, Austria
AJNR Am J Neuroradiol 33:481-6. 2012..The purpose of our research was to report the long-term angiographic and cross-sectional imaging results after placement of a PED in 12 patients with wide-neck intracranial aneurysms...
- Pipeline embolization device (PED) for neurovascular reconstruction: initial experience in the treatment of 101 intracranial aneurysms and dissectionsSebastian Fischer
Neuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Stuttgart, Germany
Neuroradiology 54:369-82. 2012..The purpose of this study was to evaluate the safety and efficacy of the recently available flow diverter "pipeline embolization device" (PED) for the treatment of intracranial aneurysms and dissections...
- Endovascular treatment of wide-neck intracranial aneurysms using a microcatheter protective technique: results and outcomes in 75 aneurysmsJ Y Lee
Department of Radiology, Seoul National University College of Medicine, Korea
AJNR Am J Neuroradiol 32:917-22. 2011..The purpose of this study was to describe this method and to evaluate its efficacy and safety as an alternative to a multiple-microcatheter or balloon- or stent-assisted technique for wide-neck aneurysms...
- Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatmentJ R Cebral
Center for Computational Fluid Dynamics, George Mason University, Fairfax, Virginia 22030, USA
AJNR Am J Neuroradiol 32:27-33. 2011Flow-diverting approaches to intracranial aneurysm treatment had many promising early results, but recent apparently successful treatments have been complicated by later aneurysm hemorrhage...
- Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm riskKatsuhito Yasuno
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 108:19707-12. 2011The pathogenesis of intracranial aneurysm (IA) formation and rupture is complex, with significant contribution from genetic factors...
- Risk of ventriculostomy-related hemorrhage in patients with acutely ruptured aneurysms treated using stent-assisted coilingDavid K Kung
Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
J Neurosurg 114:1021-7. 2011..The aim of this study was to directly quantify the risk of ventriculostomy-related hemorrhage in patients with acute aneurysmal subarachnoid hemorrhage treated with stent-assisted coiling...
- Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal studyLoic Boussel
Department of Radiology, VA Medical Center, San Francisco, USA 94121, USA
Stroke 39:2997-3002. 2008..Low wall shear stress (WSS) has been reported to have a negative effect on endothelial cells normal physiology and may be an important contributor to local remodeling of the arterial wall and to aneurysm growth and rupture...
- Thromboembolic complications of elective coil embolization of unruptured aneurysms: the effect of oral antiplatelet preparation on periprocedural thromboembolic complicationGyojun Hwang
Department of Neurosurgery, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, Korea
Neurosurgery 67:743-8; discussion 748. 2010..We retrospectively evaluated whether antiplatelet preparation lowered the thromboembolic complication rate during the perioperative period...
- Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysmsJ Caird
Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland
Eur J Neurol 13:1098-105. 2006..specimens of non-atherosclerotic intracranial aneurysms, because of the relative unavailability of fresh intracranial aneurysm tissue (i.e. reluctance to excise the aneurysm fundus at surgery)...
- Gene expression profiles in human ruptured and unruptured intracranial aneurysms: what is the role of inflammation?Joanna Pera
Department of Neurology, Jagiellonian University, Krakow, Poland
Stroke 41:224-31. 2010..The majority of studies on human tissue have focused on predefined pathways. We sought to analyze global gene expression patterns of ruptured IA, unruptured IA, and control vessels...
- Assessment of flow in perforating arteries during intracranial aneurysm surgery using intraoperative near-infrared indocyanine green videoangiographyJean G de Oliveira
Department of Neurosurgery, Neurocenter, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Neurosurgery 61:63-72; discussion 72-3. 2007..In addition, we analyzed the incidence of perforating vessels involved during the aneurysm surgery and the incidence of ischemic infarct caused by compromised small arteries...
- Incidental intracranial aneurysms: rationale for treatmentJean Raymond
Interventional Neuroradiology Research Unit, Department of Radiology, Centre Hospitalier de l Universite de Montreal, Notre Dame Hospital, Montreal, Canada
Curr Opin Neurol 22:96-102. 2009..The review critically appraises the available evidence and current rationale for treating incidental intracranial aneurysms...
- Horizontal stent-assisted coil embolisation of wide-necked intracranial aneurysms with the Enterprise stent--a case series with early angiographic follow-upMohammed Aslam Siddiqui
Department of Neuroradiology, Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK
Neuroradiology 51:411-8. 2009..The purpose of the study is to describe our experience in eight cases of horizontal stenting across the circle of Willis in patients with terminal aneurysms...
- Complement activation associates with saccular cerebral artery aneurysm wall degeneration and ruptureRiikka Tulamo
Neurosurgery Research Group, Room B408a2, Biomedicum Helsinki, P O Box 700, FI 00029 Huch, Finland
Neurosurgery 59:1069-76; discussion 1076-7. 2006..We studied how complement activation associates with SCAA wall degeneration and rupture to better understand the pathobiology of SCAA wall rupture...
- Sensitivity of noncontrast cranial computed tomography for the emergency department diagnosis of subarachnoid hemorrhageRichard L Byyny
Department of Emergency Medicine, Denver Health Medical Center, Denver, CO, USA
Ann Emerg Med 51:697-703. 2008..The purpose of this study is to determine the sensitivity of noncontrast cranial CT in detecting all spontaneous subarachnoid hemorrhages and those caused by aneurysm or arteriovenous malformation...
- Stent reconstruction of wide-necked aneurysms across the circle of WillisMichael E Kelly
Division of Cerebrovascular and Endovascular Neurosurgery, Department of Neurosurgery, The Cleveland Clinic, Cleveland, Ohio 44195, USA
Neurosurgery 61:249-54; discussion 254-5. 2007..To describe a novel technique for single stent reconstruction of wide-necked aneurysms arising from the circle of Willis...
- Treatment of intracranial aneurysms with the Enterprise stent: a multicenter registryJ Mocco
Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA
J Neurosurg 110:35-9. 2009..Recent Food and Drug Administration approval of the Enterprise Vascular Reconstruction Device and Delivery System (Cordis) has added a new option for self-expanding stent-assisted intracranial aneurysm coiling.
- Assessment of microscope-integrated indocyanine green angiography during intracranial aneurysm surgery: a retrospective study of 120 patientsJin Li
Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guo Xue Xiang Street, Chengdu 610 041, China
Neurol India 57:453-9. 2009The purpose of this study was to assess the clinical value of indocyanine green angiography (ICG) in intracranial aneurysm surgery by comparing the findings with postoperative angiographic results.
- The critical role of hemodynamics in the development of cerebral vascular diseaseAlexander M Nixon
Department of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Neurosurg 112:1240-53. 2010..The recognition of WSS as an important factor in cerebral vascular disease may help to identify individuals at risk and guide treatment options...
- Intraoperative indocyanine green angiography in intracranial aneurysm surgery: Microsurgical clipping and revascularizationChi Yuan Ma
Department of Neurosurery, Nanjing Jinling Hospital, Nanjing University, School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China
Clin Neurol Neurosurg 111:840-6. 2009..The goal of this report is to illustrate the use of intraoperative indocyanine green (ICG) angiography in the surgical management of intracranial aneurysms, including microsurgical clipping and revascularization...
- Early fatal hemorrhage after endovascular cerebral aneurysm treatment with a flow diverter (SILK-Stent): do we need to rethink our concepts?Bernd Turowski
Institute of Radiology Neuroradiology, University of Duesseldorf, Duesseldorf, Germany
Neuroradiology 53:37-41. 2011..All available data were reviewed and beside hemodynamic factors instability of the intra-aneurysmal thrombus is discussed as a possible cofactor leading to this disastrous event...
- Coil embolization of anterior circulation aneurysms supported by the Solitaire AB Neurovascular Remodeling DeviceJoachim Klisch
Department of Diagnostic and Interventional Radiology and Neuroradiology, Helios General Hospital Erfurt, Nordhauser Str 74, 99089, Erfurt, Germany
Neuroradiology 52:349-59. 2010..The purpose of the study is to evaluate patients with wide-necked or complex aneurysms of the anterior circulation who underwent Solitaire AB Neurovascular Remodeling Device-assisted coil embolization...
- Cerebral Aneurysm Multicenter European Onyx (CAMEO) trial: results of a prospective observational study in 20 European centersAndrew J Molyneux
Neurovascular Research Unit, Radcliffe Infirmary, Oxford, UK
AJNR Am J Neuroradiol 25:39-51. 2004....
- Treatment of a wide-necked aneurysm of the anterior cerebral artery using two Enterprise stents in "Y"-configuration stenting technique and coil embolization: a technical noteStefan Rohde
Department of Neuroradiology, University of Heidelberg Medical Centre, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
Neuroradiology 52:231-5. 2010..We report a 52-year-old woman with recurrence of a wide-necked aneurysm of the anterior cerebral artery that was successfully retreated by stent-assisted coiling using the "Y"-stenting technique with the Enterprise stent system...
- Endovascular coil embolization of very small intracranial aneurysmsJin Ho Hwang
Department of Radiology, Konkuk University Medical Center, 4 12 Hwayang dong, Gwangjin gu, Seoul, 143 729, South Korea
Neuroradiology 53:349-57. 2011..We report clinical and angiographic results of coil embolization of these aneurysms...
- MR angiography at 3T versus digital subtraction angiography in the follow-up of intracranial aneurysms treated with detachable coilsCharles B L M Majoie
Department of Radiology, Academic Medical Center, University of Amsterdam, The Netherlands
AJNR Am J Neuroradiol 26:1349-56. 2005..We assessed the feasibility and usefulness of 3D time-of-flight (TOF) MR angiography (MRA) performed at 3T compared with DSA for the follow-up of coil-treated intracranial aneurysms...
- HYPOTHERMIA DURING INTRACRANIAL ANEURYSM SURGERYMichael Todd; Fiscal Year: 2003..means of reducing early and long-term postoperative neurologic morbidity following surgery for clipping of intracranial aneurysm. Control patients will remain normothermic during and after surgery; in hypothermic patients, body ..
- The Role of Mast Cells in the Pathophysiology of Intracranial AneurysmTomoki Hashimoto; Fiscal Year: 2013..We have developed a novel mouse model of intracranial aneurysm. In this model, spontaneous aneurysmal rupture occurs with a predictable time course...
- EVOLVING MECHANICS OF INTRALUMINAL THROMBUS: FROM FORMATION TO ORGANIZATIONJay D Humphrey; Fiscal Year: 2010..cerebral vasospasm, the leading cause of morbidity and mortality in patients surviving the rupture of an intracranial aneurysm, correlates strongly with clot burden and clot clearance rates...
- Molecular Imaging to Determine the Risk of Rupture of Cerebral AneurysmsAlexei Bogdanov; Fiscal Year: 2009..above, we hypothesize that some of the MPO-specific effects in plaque progression could also contribute to intracranial aneurysm instability...
- Cerebral Aneurysm Clipping Training Simulator using Virtual Reality and HapticsP Pat Banerjee; Fiscal Year: 2013..We also modeled aneurysm clips in 3D. Phase II focuses on programming the simulator for craniotomy, dural opening, and aneurysm clipping, and on validation. ..
- Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling and InflammationTomoki Hashimoto; Fiscal Year: 2013..Our preliminary data using a newly developed mouse model of intracranial aneurysm show that ovariectomy (surgical menopause) increased the incidence of intracranial aneurysms in female ..
- Molecular Variants that Determine Genetic Susceptibility to Intracranial AneurysmMurat Gunel; Fiscal Year: 2013..abstract_text> ..
- Constrictor / Mitogen Induced Remodeling of Cerebral ArteriolesJAY HUMPHREY; Fiscal Year: 2009..of patients presenting with a subarachnoid hemorrhage (SAH), the most common cause of which is a ruptured intracranial aneurysm. This delayed process has traditionally been associated with a short-term but marked reduction in the ..
- Determinants of Intracranial Aneurysm GrowthDavid A Saloner; Fiscal Year: 2013..That information will be used to guide clinicians as to what interventional treatments might be considered, and when they might best be implemented. ..
- A new parameter for prediction of intracranial aneurysm hemodynamics and risk ofIman Borazjani; Fiscal Year: 2013DESCRIPTION (provided by applicant): A new parameter for prediction of intracranial aneurysm hemodynamics and risk of rupture Summary Quantifying the likelihood of aneurysm rupture is a significant clinical goal...
- Hemodynamics in Intracranial Aneurysm PathogenesisDANIEL MARCELO SFORZA; Fiscal Year: 2012..This project will not only shed light into the underlying mechanisms governing aneurysm initiation, but also will guide the development of clinical tools for the evaluation and treatment of cerebral aneurysms. ..
- Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial AneurysmsHui Meng; Fiscal Year: 2013Little is known about intracranial aneurysm (IA) formation. We submit that specific hemodynamic conditions, not evaluated in prior aneurysm models, are critical for IA formation...
- Elucidating cardiovascular phenotaypes employing genome editing of iPS cellsERIC JEFFREY TOPOL; Fiscal Year: 2013..A genomic variant associated with CAD, myocardial infarction (Ml), abdominal aortic aneurysm, and intracranial aneurysm is found in a stretch of chr9p21 devoid of known genes...
- THE OPTIMAL MANAGEMENT OF CEREBRAL ANEURYSMSJoseph King; Fiscal Year: 2004..of cerebral aneurysms implies that 2,000,000 to 10,000,000 adults in the United States may harbor an intracranial aneurysm. Each year 21,000 of these individuals suffer a subarachnoid hemorrhage, resulting in significant ..
- MAPPING INTRACRANIAL ANEURYSM SUSCEPTIBILITY LOCILisa Cannon Albright; Fiscal Year: 2001..Little is known about susceptibility to intracranial aneurysm (IA), although it is well recognized that there is a familial component, likely to be genetic in origin...
- RANDOMIZED STUDY OF NICARDIPINE IN SAHNeal Kassell; Fiscal Year: 1992Approximately 28,000 individuals in North America have a subarachnoid hemorrhage from a ruptured intracranial aneurysm each year...
- New Polymer Cerebral Aneurysm Filler DeviceROBERT BOOCK; Fiscal Year: 2001..S. The incidence of an intracranial aneurysm in the general population has been estimated to be between 1.5% to 8%...
- New Polymer Cerebral Aneurysm Filler DeviceJeffrey Lee; Fiscal Year: 2004..S. The incidence of an intracranial aneurysm in the general population has been estimated to be between 1.5% to 8%...
- DNA LINKAGE ANALYSIS IN INTRACRANIAL ANEURYSM FAMILIESGERARDUS TROMP; Fiscal Year: 2001....
- SUPPORT FOR CEREBROVASCULAR RESEARCH CENTERJames Robertson; Fiscal Year: 1980..To develop a model of spontaneously occurring intracranial aneurysm which is identifiable by arteriography and frequent in production...
- SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTYDavid Kallmes; Fiscal Year: 2008..abstract_text> ..
- Hemodynamic Intervention of Intracranial AneurysmsHui Meng; Fiscal Year: 2008..A multi-faceted plan is proposed to train in areas of translational neurovascular intervention, integrative cerebrovascular biology and medical imaging. ..
- Improved Animal Modeling of Saccular AneurysmsDavid F Kallmes; Fiscal Year: 2010..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
- Genetic and Tissue Engineering for AneurysmsDavid Kallmes; Fiscal Year: 2004..Successful implementation of this research program will advance the field of genetic and tissue engineering and will improve the care of patients harboring life-threatening cerebral aneurysms. ..
- Identification of Novel Biomarkers in HDTatiana Foroud; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- GENES FOR ALCOHOLISM SUSCEPTIBILITYTatiana Foroud; Fiscal Year: 2003..These studies will result in more sophisticated genetic analyses of alcoholism related data, as well as the development of optimum sampling designs for more efficient gene identification. ..
- GENETIC ANALYSIS OF HIP FRAGILITYTatiana M Foroud; Fiscal Year: 2010..Our goal is to find genetic causes for bone weakening conditions like osteoporosis so better treatments can be developed. ..
- A Cross-Cultural Longitudinal Assessment of FASD (U24)Tatiana Foroud; Fiscal Year: 2005..abstract_text> ..
- PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGETatiana M Foroud; Fiscal Year: 2010..2. Study the role of parkin mutations in Parkinson's disease. 3. Perform molecular studies to identify PD susceptibility genes. 4. Evaluate putative PD susceptibility genes in a case-control sample. ..
- PD GWAS ConsortiumTatiana M Foroud; Fiscal Year: 2010....
- Longitudinal Studies Among At-Risk HD Gene CarriersTatiana Foroud; Fiscal Year: 2006..abstract_text> ..
- Familial Intracranial Aneurysm Study II (FIA II)JOSEPH PAUL BRODERICK; Fiscal Year: 2010..Our experienced collaborative and highly productive team of Familial Intracranial Aneurysm (FIA) Investigators at 27 original sites in North America, Australia and New Zealand accomplished and ..
- THE VALIDITY OF CE-MRA: A NUMERICAL AND PHANTOM STUDYLiang Der Jou; Fiscal Year: 2002..It is anticipated that this project will provide improved tools for the understanding of Contrast-Enhanced MRA and will lead to more accurate and reliable methods for assessing vascular disease in vivo. ..
- THE VALIDITY OF CE-MRA: A NUMERICAL AND PHANTOM STUDYLiang Der Jou; Fiscal Year: 2003..It is anticipated that this project will provide improved tools for the understanding of Contrast-Enhanced MRA and will lead to more accurate and reliable methods for assessing vascular disease in vivo. ..
- Interventional Management of Stroke III Planning GrantJoseph Broderick; Fiscal Year: 2004..10. Explore funding of interventional angiography by CMS. 11. Continue interaction with industry, with attention to devices that might be applied to a device-augmented future IV/IA paradigm. ..
- Familial Aggregation of StrokeDaniel Woo; Fiscal Year: 2005..Determining the component of the familial aggregation of ICH that is independent of the familial aggregation of environmental risk factors is a fundamental step in the analysis of the genetic epidemiology of stroke. ..
- Ex Vivo Delineation of Mechanisms of Cerebral VasospasmJAY HUMPHREY; Fiscal Year: 2008..In summary, we submit that this project will reveal new insight into mechanisms. ..
- Prednisone Ocular Myasthenia Gravis Trial Planning GrantMark Kupersmith; Fiscal Year: 2004....
- Novel Organ Culture & Theory for Arteriolar RemodelingJAY HUMPHREY; Fiscal Year: 2005..We will collect simultaneous pressure-diameter, cell morphological, and actin cytoskeletal data at multiple times during the remodeling, which in turn will allow us to develop a novel, single theoretical framework. ..
- Histo-Mechanics & Biology of Remodeling in HypertensionJAY HUMPHREY; Fiscal Year: 2005..Subsequent parallel studies will focus on additional pharmacological agents and gender-related differences. ..
- Quality of Life in Patients with Brain MetastasesJoseph King; Fiscal Year: 2005..abstract_text> ..
- Unruptured Intracranial Aneurysms: Neurologic OutcomeRobert Brown; Fiscal Year: 2007..abstract_text> ..
- OPTIMIZING MANAGEMENT OF TRANSIENT ISCHEMIC ATTACKSS Johnston; Fiscal Year: 2005..This research will provide important results for clinicians and policy makers, and will foster the applicant's development as a health services researcher in cerebrovascular disease. ..
- In vivo multichannel fluorescent imagingUmar Mahmood; Fiscal Year: 2007....
- Mechanical Stress and the Heat-Treatment of Soft TissueJAY HUMPHREY; Fiscal Year: 2003..There is a need for a firmer scientific understanding. ..
- RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODELMichael Lawton; Fiscal Year: 2004..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs. ..
- Siblings With Ischemic Stroke Study (SWISS)JAMES MESCHIA; Fiscal Year: 2009..DNA banking and the creation of permanent lymphoblastoid cell lines will be done to permit future collaborative efforts to study the genetic basis for stroke risk. ..
- Study of design variables of the endovascular graftMADHAVAN RAGHAVAN; Fiscal Year: 2007..Improvements in implant design will significantly improve post-operative quality of life for patients in the US and world-wide. [unreadable] [unreadable] [unreadable]..
- Cognitive Function After Intracranial Aneurysm SurgerySatwant Samra; Fiscal Year: 2005..Information gained from this investigation will be important in giving a prognosis for returning back to work as well as planning rehabilitation of patients suffering from aneurysmal SAH in future. ..
- ISGS: The Ischemic Stroke Genetics StudyJAMES MESCHIA; Fiscal Year: 2006..The application and SWISS share the same definitions for the present and absence of phenotype and key enrollment criteria. ..
- ENDOTHELIAL DYSFUNCTION: FORMATION OF MICROPARTICLESSergey Brodsky; Fiscal Year: 2005..The proposed studies may provide novel information on the contribution of microparticles to the pathophysiology of endothelial cell dysfunction and coagulation abnormalities. ..
- POLARIZED LIGHT PROPAGATION AND IMAGING IN TISSUEDuncan Maitland; Fiscal Year: 2002..At the conclusion of this work, the applicants anticipate being able to propose the construction and testing of a system for use in small animal imaging and pre-clinical trials for detection of tumors embedded in healthy tissue. ..