thoracic aortic aneurysm

Summary

Summary: An aneurysm in the proximal portion of the descending aorta proceeding from the arch of the aorta and giving rise to the bronchial, esophageal, pericardiac, and mediastinal branches.

Top Publications

  1. ncbi Thoracic and abdominal aortic aneurysms
    Eric M Isselbacher
    Thoracic Aortic Center and Cardiology Division, Massachusetts General Hospital, 55 Fruit St, YAW 5A 5800, Boston, MA 02114, USA
    Circulation 111:816-28. 2005
  2. ncbi Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus
    Limin Zhu
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Département de génétique, 75015 Paris, France
    Nat Genet 38:343-9. 2006
  3. ncbi Oxidative stress in the pathogenesis of thoracic aortic aneurysm: protective role of statin and angiotensin II type 1 receptor blocker
    Junya Ejiri
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Cardiovasc Res 59:988-96. 2003
  4. ncbi Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9
    Ada W Y Chung
    Child and Family Research Institute, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
    Circ Res 102:e73-85. 2008
  5. ncbi Thoracic aortic aneurysm clinically pertinent controversies and uncertainties
    John A Elefteriades
    Cardiac Surgery, Yale University School of Medicine, Boardman 2, 333 Cedar Street, New Haven, Connecticut 06510, USA
    J Am Coll Cardiol 55:841-57. 2010
  6. ncbi Endovascular treatment of thoracic aortic diseases: combined experience from the EUROSTAR and United Kingdom Thoracic Endograft registries
    Lina J Leurs
    EUROSTAR and UK Thoracic Aortic Data Registry, Catharina Hospital, Eindhoven, The Netherlands
    J Vasc Surg 40:670-9; discussion 679-80. 2004
  7. ncbi Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections
    Hariyadarshi Pannu
    Department of Internal Medicine, Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA
    Circulation 112:513-20. 2005
  8. ncbi Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm
    Maria Nataatmadja
    Department of Medicine, University of Queensland, Prince Charles Hospital, Brisbane, Australia
    Circulation 108:II329-34. 2003
  9. ncbi Anesthetic consideration for descending thoracic aortic aneurysm repair
    Ronald A Kahn
    Department of Anesthesiology, The Mount Sinai School of Medicine, New York, New York 10029 6547, USA
    Semin Cardiothorac Vasc Anesth 11:205-23. 2007
  10. pmc Alterations in aortic cellular constituents during thoracic aortic aneurysm development: myofibroblast-mediated vascular remodeling
    Jeffrey A Jones
    Division of Cardiothoracic Surgery Research, Department of Surgery, Medical University of South Carolina, Strom Thurmond Research Building, 114 Doughty Street, Suite 625, Charleston, SC 29425, USA
    Am J Pathol 175:1746-56. 2009

Detail Information

Publications229 found, 100 shown here

  1. ncbi Thoracic and abdominal aortic aneurysms
    Eric M Isselbacher
    Thoracic Aortic Center and Cardiology Division, Massachusetts General Hospital, 55 Fruit St, YAW 5A 5800, Boston, MA 02114, USA
    Circulation 111:816-28. 2005
  2. ncbi Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus
    Limin Zhu
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Département de génétique, 75015 Paris, France
    Nat Genet 38:343-9. 2006
    We have recently described two kindreds presenting thoracic aortic aneurysm and/or aortic dissection (TAAD) and patent ductus arteriosus (PDA) and mapped the disease locus to 16p12.2-p13.13 (ref. 3)...
  3. ncbi Oxidative stress in the pathogenesis of thoracic aortic aneurysm: protective role of statin and angiotensin II type 1 receptor blocker
    Junya Ejiri
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Cardiovasc Res 59:988-96. 2003
    ..We investigated the potential role of p22phox-based NADH/NADPH oxidase in the pathogenesis of TAA...
  4. ncbi Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9
    Ada W Y Chung
    Child and Family Research Institute, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
    Circ Res 102:e73-85. 2008
    Beta-blockers, eg, atenolol, are the cornerstone therapy for thoracic aortic aneurysm (TAA) in patients with Marfan syndrome; however, continued aortic dilatation has been reported...
  5. ncbi Thoracic aortic aneurysm clinically pertinent controversies and uncertainties
    John A Elefteriades
    Cardiac Surgery, Yale University School of Medicine, Boardman 2, 333 Cedar Street, New Haven, Connecticut 06510, USA
    J Am Coll Cardiol 55:841-57. 2010
    This paper addresses clinical controversies and uncertainties regarding thoracic aortic aneurysm and its treatment...
  6. ncbi Endovascular treatment of thoracic aortic diseases: combined experience from the EUROSTAR and United Kingdom Thoracic Endograft registries
    Lina J Leurs
    EUROSTAR and UK Thoracic Aortic Data Registry, Catharina Hospital, Eindhoven, The Netherlands
    J Vasc Surg 40:670-9; discussion 679-80. 2004
    ..treatment of thoracic aortic aneurysms and dissections collated in the European Collaborators on Stent Graft Techniques for Thoracic Aortic Aneurysm and Dissection Repair (EUROSTAR) and the United Kingdom Thoracic Endograft registries.
  7. ncbi Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections
    Hariyadarshi Pannu
    Department of Internal Medicine, Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA
    Circulation 112:513-20. 2005
    ..Having mapped a TAAD locus to 3p24-25, we sequenced the gene for transforming growth factor-beta receptor type II (TGFBR2) to determine whether mutations in this gene resulted in familial TAAD...
  8. ncbi Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm
    Maria Nataatmadja
    Department of Medicine, University of Queensland, Prince Charles Hospital, Brisbane, Australia
    Circulation 108:II329-34. 2003
    ..The role of matrix metalloproteinase (MMP)-2 in VSMC apoptosis was studied in MS aneurysm...
  9. ncbi Anesthetic consideration for descending thoracic aortic aneurysm repair
    Ronald A Kahn
    Department of Anesthesiology, The Mount Sinai School of Medicine, New York, New York 10029 6547, USA
    Semin Cardiothorac Vasc Anesth 11:205-23. 2007
    ..In this review, etiologies, natural history, and surgical techniques of thoracic aortic aneurysm are presented...
  10. pmc Alterations in aortic cellular constituents during thoracic aortic aneurysm development: myofibroblast-mediated vascular remodeling
    Jeffrey A Jones
    Division of Cardiothoracic Surgery Research, Department of Surgery, Medical University of South Carolina, Strom Thurmond Research Building, 114 Doughty Street, Suite 625, Charleston, SC 29425, USA
    Am J Pathol 175:1746-56. 2009
    ..endogenous cellular population accompany alterations in aortic collagen and elastin content during thoracic aortic aneurysm (TAA) development in a murine model...
  11. ncbi Aberrant subclavian artery and Kommerell aneurysm: surgical treatment with a standard approach
    Nicholas T Kouchoukos
    Division of Cardiovascular and Thoracic Surgery, Missouri Baptist Medical Center, St Louis, Missouri, USA
    J Thorac Cardiovasc Surg 133:888-92. 2007
    ..We report our experience with a standard surgical technique for treatment of aneurysms associated with Kommerell diverticulum and aberrant subclavian artery...
  12. ncbi Endovascular stent-graft placement for the treatment of acute aortic dissection
    M D Dake
    Division of Cardiovascular and Interventional Radiology, Stanford University School of Medicine, Calif, USA
    N Engl J Med 340:1546-52. 1999
    ..Irrespective of the form of treatment, the associated mortality and morbidity are considerable...
  13. ncbi Effect of aneurysm on the tensile strength and biomechanical behavior of the ascending thoracic aorta
    David A Vorp
    Department of Surgery and Bioengineering, University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania 15219, USA
    Ann Thorac Surg 75:1210-4. 2003
    Rupture of an ascending thoracic aortic aneurysm (ATAA), which is associated with significant mortality, occurs when the mechanical forces acting on the aneurysm exceed the strength of the degenerated aortic wall...
  14. pmc Acute aortic syndromes and thoracic aortic aneurysm
    Vijay S Ramanath
    Section of Cardiology, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Mayo Clin Proc 84:465-81. 2009
    ..were conducted using the following keywords: aortic dissection, intramural hematoma, aortic ulcer, and thoracic aortic aneurysm. Retrospective and prospective studies performed within the past 20 years were included in the review; ..
  15. ncbi Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections
    Rumin He
    Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, Tex 77030, USA
    J Thorac Cardiovasc Surg 131:671-8. 2006
    ..This study sought to determine whether inflammatory cells are present in medial degeneration and assess any possible contribution of these cells to apoptosis of smooth muscle cells...
  16. ncbi Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002
    Christian Olsson
    Department of Cardiothoracic Surgery, Uppsala University Hospital, Uppsala, Sweden
    Circulation 114:2611-8. 2006
    ..The objective of the present study was to reappraise epidemiology and long-term outcomes in subjects with thoracic aortic disease in a large contemporary population...
  17. pmc Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis
    Jeffrey A Jones
    Department of Surgery, Division of Cardiothoracic Surgery Research, Medical University of South Carolina, Charleston, S C 29425, USA
    J Vasc Res 46:119-37. 2009
    ....
  18. ncbi Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections
    George J Koullias
    Section of Cardiothoracic Surgery, Yale New Haven Hospital, New Haven, Connecticut 06510, USA
    Ann Thorac Surg 78:2106-10; discussion 2110-1. 2004
    ..We applied tissue microarray analysis to determine MMP profiles in a large group of surgically resected thoracic aneurysms and dissections...
  19. ncbi Familial thoracic aortic aneurysms and dissections--incidence, modes of inheritance, and phenotypic patterns
    Gonzalo Albornoz
    Section of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Thorac Surg 82:1400-5. 2006
    ..We examined the genetic nature and phenotypic features of thoracic aortic aneurysms (TAAs) and dissections in a large cohort of patients...
  20. ncbi Familial thoracic aortic aneurysms and dissections: genetic heterogeneity with a major locus mapping to 5q13-14
    D Guo
    Department of Internal Medicine, University of Texas Houston Medical School, Houston, TX 77030, USA
    Circulation 103:2461-8. 2001
    ..Families identified with dominant inheritance of thoracic aortic aneurysms and dissections (TAA/dissections) indicate that single gene mutations can cause medial necrosis in the absence of an associated syndrome...
  21. ncbi Early surgical experience with Loeys-Dietz: a new syndrome of aggressive thoracic aortic aneurysm disease
    Jason A Williams
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 83:S757-63; discussion S785-90. 2007
    ..Our surgical experience with LDS was reviewed to assess outcomes and develop guidelines for management of this aggressive disease...
  22. ncbi Aortoesophageal fistula secondary to stent-graft repair of the thoracic aorta
    Holger Eggebrecht
    Department of Cardiology, West German Heart Center, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    J Endovasc Ther 11:161-7. 2004
    ..To report the incidence and management of aortoesophageal fistula (AEF) secondary to endovascular stent-graft repair of the descending thoracic aorta...
  23. doi Thoracic aortic aneurysm: reading the enemy's playbook
    John A Elefteriades
    Curr Probl Cardiol 33:203-77. 2008
    ..database of the Yale Center for Thoracic Aortic Disease--which includes information on 3000 patients with thoracic aortic aneurysm or dissection, with 9000 catalogued images and 9000 patient-years of follow-up--has, over the last decade,..
  24. ncbi Branched endovascular repair of aortic arch aneurysm with a modular stent-graft system
    Darren B Schneider
    Division of Vascular Surgery, University of California San Francisco, San Francisco, CA, USA
    J Vasc Surg 38:855. 2003
  25. ncbi Airway obstruction secondary to thoracic aortic aneurysm leak. A case report
    Omar Sabra
    Medical Center, American University of Beirut, Beirut PO Box 11 0236, 11072020 Riad El Solh Beirut, Lebanon
    Eur Arch Otorhinolaryngol 263:1144-6. 2006
    ..We believe that our case is the second case of retropharyngeal hematoma caused by a leaking aortic aneurysm. A case discussion and management is presented in this article...
  26. ncbi Role and results of surgery in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD)
    Santi Trimarchi
    Cardiovascular Center E Malan, Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Italy
    Circulation 114:I357-64. 2006
    ....
  27. ncbi Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients
    Kimihiko Kato
    Department of Cardiovascular Medicine, Gifu Prefectural Government TAJIMI Hospital, Tajimi, Japan
    Am J Hypertens 21:1023-7. 2008
    Conventional risk factors for thoracic aortic aneurysm including dissection (TAA) are thought to include age, arteriosclerosis, and hypertension...
  28. ncbi Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection
    Siwei Peng
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Lab Invest 87:1195-205. 2007
    The pathogenesis of sporadic thoracic aortic aneurysm and dissection, which may lead to rupture of the aorta, remains largely unknown. Amyloid deposits, formed from the medin peptide, are very prevalent in the media of the thoracic aorta...
  29. ncbi Delayed response of transcranial myogenic motor-evoked potential monitoring to spinal cord ischemia during repair surgery for descending thoracic aortic aneurysm
    Manabu Kakinohana
    Department of Anesthesiology, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    J Anesth 22:304-7. 2008
    ..We must be aware that tc-MEPs recorded from the lower extremities can fail to provide rapid detection of spinal cord ischemia in the upper thoracic level after cross-clamping of the descending thoracic aorta...
  30. ncbi Vocal cord paralysis after surgery for thoracic aortic aneurysm
    Shin Ichi Ishimoto
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo
    Chest 121:1911-5. 2002
    To determine the incidence, etiology, prognosis, and treatment of vocal cord paralysis (VCP) after surgery for thoracic aortic aneurysm (TAA).
  31. ncbi Superior nationwide outcomes of endovascular versus open repair for isolated descending thoracic aortic aneurysm in 11,669 patients
    Raja R Gopaldas
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    J Thorac Cardiovasc Surg 140:1001-10. 2010
    ..Little is known about TEVAR's nationwide effect on patient outcomes. We evaluated nationwide data regarding the short-term outcomes of TEVAR and open aortic repair (OAR) procedures performed in the United States during a 2-year period...
  32. ncbi Endovascular treatment of thoracic aortic disease: four years of experience
    Alessandro S Bortone
    Dipartimento Emergenza e Trapianti d Organo, Sezione di Cardiochirurgia, Piazza Giulio Cesare 11 70124 Bari, Italy
    Circulation 110:II262-7. 2004
    ..The aim of this retrospective study is to investigate efficacy and middle-term results of the stent graft treatment for diseases of descending thoracic aorta...
  33. ncbi Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms
    Paul C Y Tang
    Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, Connecticut, USA
    FASEB J 19:1528-30. 2005
    ..Th1, but not Th2, immune responses have a positive correlation with both outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms...
  34. ncbi Evaluation of recurrent nerve paralysis due to thoracic aortic aneurysm and aneurysm repair
    Kosuke Ishii
    Department of Otorhinolaryngology, Omiya Medical Center, Jichi Medical School, 1 847 Amanuma cho, Saitama shi, Saitama 330 8503, Japan
    Laryngoscope 114:2176-81. 2004
    We sought to clarify the relationship between the outcome of recurrent laryngeal nerve paralysis with the characteristics of the thoracic aortic aneurysm and the surgical procedure used in each patient.
  35. ncbi Endoleaks following endovascular repair of thoracic aortic aneurysm: etiology and outcomes
    Jose P Morales
    Department of Vascular and Endovascular Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    J Endovasc Ther 15:631-8. 2008
    To evaluate the incidence and natural history of endoleaks following thoracic endovascular aortic repair (TEVAR) of thoracic aortic aneurysm (TAA).
  36. ncbi Mutation of ACTA2 gene as an important cause of familial and nonfamilial nonsyndromatic thoracic aortic aneurysm and/or dissection (TAAD)
    Hiroko Morisaki
    Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan
    Hum Mutat 30:1406-11. 2009
    ..These findings confirm that ACTA2 mutations are important in familial TAAD, while the first sporadic and young-onset TAAD case with an ACTA2 mutation was also identified...
  37. ncbi Unusual presentation of ruptured descending thoracic aortic aneurysm
    Pasquale Totaro
    Cardiac Surgery Division, Morriston Hospital, Swansea, UK
    J Cardiovasc Med (Hagerstown) 8:291-2. 2007
    We here report a very unusual presentation of ruptured thoracic aortic aneurysm. In a 50-year-old patient, almost asymptomatic and in stable clinical conditions, the chest radiograph and computed tomography scan revealed a right-sided ..
  38. ncbi Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model
    Liang Geng
    Department of Cardiology, Rui Jin Hospital, Jiao Tong University School of Medicine, Shanghai 200025, People s Republic of China
    Exp Mol Pathol 89:72-81. 2010
    This study was designed to establish a rat model of thoracic aortic aneurysm (TAA) by calcium chloride (CaCl(2))-induced arterial injury and to explore the potential role of a disintegrin and metalloproteinase (ADAM), matrix ..
  39. pmc Thoracic aortic aneurysm: reading the enemy's playbook
    John A Elefteriades
    Section of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Yale J Biol Med 81:175-86. 2008
    ..we have been using our clinical experience and laboratory investigations to shed light on the pathophysiology of thoracic aortic aneurysm (TAA), the clinical behavior of thoracic aortic aneurysm, and the optimal clinical management.
  40. ncbi Midterm results of endovascular repair of descending thoracic aortic aneurysms with first-generation stent grafts
    Philippe Demers
    Department of Cardiovascular Surgery, Division of Cardiovascular and Interventional Radiology, Stanford University School of Medicine, Stanford, CA 94305 5247, USA
    J Thorac Cardiovasc Surg 127:664-73. 2004
    ..Five years after reporting our initial stent-graft repair of descending thoracic aortic aneurysms experience, we determined the 5- to 10-year results of stent-graft treatment and identified risk factors for adverse late outcomes...
  41. ncbi Acute dissecting thoracic aortic aneurysm in a patient with polymyalgia rheumatica
    Tomohiro Koga
    Department of General Internal Medicine, NHO National Nagasaki Medical Center, Nagasaki, Japan
    Am J Med Sci 334:386-8. 2007
    ....
  42. ncbi Proteinase systems and thoracic aortic aneurysm progression
    John R Barbour
    Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Surg Res 139:292-307. 2007
    ....
  43. ncbi Endovascular repair of a right-sided descending thoracic aortic aneurysm with a right-sided aortic arch and aberrant left subclavian artery
    Joseph J Naoum
    the Texas Heart Institute at St Luke s Episcopal Hospital, and Division of Vascular and Endovascular Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann Thorac Surg 85:1074-6. 2008
    ..We also review the literature associated with this particular anatomic presentation...
  44. pmc Spatiotemporal expression and localization of matrix metalloproteinas-9 in a murine model of thoracic aortic aneurysm
    Jeffrey A Jones
    Department of Surgery, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    J Vasc Surg 44:1314-21. 2006
    ..The goal of this study was to determine the spatiotemporal changes in MMP-9 expression and abundance in the early stages of aortic dilatation during the course of thoracic aortic aneurysm (TAA) formation in a mouse model.
  45. ncbi Sudden death caused by dissecting thoracic aortic aneurysm in a patient with autosomal dominant polycystic kidney disease
    Chien Chang Lee
    Department of Emergency Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Resuscitation 63:93-6. 2004
    ..However, there are few reports on the dissecting thoracic aortic aneurysm as a fatal complication of ADPKD...
  46. ncbi Immediate versus delayed endovascular treatment of post-traumatic aortic pseudoaneurysms and type B dissections: retrospective analysis and premises to the upcoming European trial
    Alessandro S Bortone
    Division of Cardiovascular Surgery, Department of Emergency and Transplantation, University of Bari School of Medicine, Bari, Italy
    Circulation 106:I234-40. 2002
    ....
  47. ncbi Is aortic dilatation an atherosclerosis-related process? Clinical, laboratory, and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation
    Yoram Agmon
    Division of Cardiovascular Diseases and Internal Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 42:1076-83. 2003
    ..The study determined, in a population-based setting, whether dilatation of the thoracic aorta is an atherosclerosis-related process...
  48. pmc Primary aortoesophageal fistula due to thoracic aortic aneurysm: successful surgical treatment
    Christos Prokakis
    Department of Cardiothoracic Surgery, School of Medicine, University of Patras, 26500 Patras, Greece
    Tex Heart Inst J 36:607-10. 2009
    ..and severe septicemia consequent to esophageal erosion and rupture of a chronic degenerative descending thoracic aortic aneurysm. The patient underwent successful surgical treatment by aorto-aortic bypass and bipolar esophageal ..
  49. pmc Altered transforming growth factor-beta signaling in a murine model of thoracic aortic aneurysm
    Jeffrey A Jones
    Department of Surgery, Division of Cardiothoracic Surgery Research, Medical University of South Carolina, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC 29425, USA
    J Vasc Res 45:457-68. 2008
    ..Accordingly, the hypothesis that alterations in TGF-beta signaling occur during aneurysm formation was tested in a murine model of TAA...
  50. ncbi Complications of endovascular repair of high-risk and emergent descending thoracic aortic aneurysms and dissections
    Christopher J Hansen
    Department of Vascular Surgery, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    J Vasc Surg 40:228-34. 2004
    ..The development of this approach includes complications that are common to the endovascular treatment of abdominal aortic aneurysms and some that are unique to thoracic endografting...
  51. ncbi Pathogenesis of thoracic and abdominal aortic aneurysms
    Dong Chuan Guo
    Department of Internal Medicine, University of Texas Medical School, Houston, 6431 Fannin, MSB 6 039, Houston, TX 77030, USA
    Ann N Y Acad Sci 1085:339-52. 2006
    ..This review focuses on the comparison of the pathologic mechanisms involved in TAA and AAA...
  52. ncbi TGFBR1 and TGFBR2 mutations in patients with features of Marfan syndrome and Loeys-Dietz syndrome
    Krishna Kumar Singh
    Institute of Human Genetics, Hannover Medical School, Hannover, Germany
    Hum Mutat 27:770-7. 2006
    ..In TGFBR2, five mutations and six polymorphisms were identified. Reexamination of patients with a TGFBR1 or TGFBR2 mutation revealed extensive clinical overlap between patients with MFS1, MFS2, and LDS...
  53. ncbi Mycotic aneurysms of the thoracic and abdominal aorta and iliac arteries: experience with anatomic and extra-anatomic repair in 33 cases
    B T Müller
    Department of Vascular Surgery and Kidney Transplantation, Heinrich Heine University, Dusseldorf, Germany
    J Vasc Surg 33:106-13. 2001
    ..The aim of our study was to find out whether any progress could be achieved in a single center over a long time period (18 years) through use of surgical techniques and antiseptic adjuncts...
  54. ncbi Spinal cord ischemia after elective stent-graft repair of the thoracic aorta
    Roberto Chiesa
    Division of Vascular Surgery, Vita Salute University, Scientific Institute H San Raffaele, Italy
    J Vasc Surg 42:11-7. 2005
    ..We reviewed our experience to investigate the determinants of paraplegia after stent-graft repair of the thoracic aorta, identify patients at risk, and assess the effectiveness of ancillary techniques...
  55. ncbi Thoracic aortic emergencies: impact of endovascular surgery
    Gabriele Iannelli
    Department of Cardiac Surgery, University Federico II of Naples, Naples, Italy
    Ann Thorac Surg 77:591-6. 2004
    ..To obviate this risk, endovascular surgery is considered to be a valid alternative procedure...
  56. ncbi Interventional strategies for treatment of aortic dissection
    C A Nienaber
    Division of Cardiology, University Hospital Rostock, Rostock School of Medicine, Rostock, Germany
    J Cardiovasc Surg (Torino) 47:487-96. 2006
    ..With the use and interpretation of current information the reader will understand the potential of interventional stent-graft induced thoracic aortic repair in type B aortic dissection...
  57. ncbi Feasibility of the Inoue single-branched stent-graft implantation for thoracic aortic aneurysm or dissection involving the left subclavian artery: short- to medium-term results in 17 patients
    Naritatsu Saito
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    J Vasc Surg 41:206-12; discussion 212. 2005
    ..This study assessed the short- to medium-term clinical results of the Inoue single-branched stent graft for repair of thoracic aortic aneurysms or dissections involving the left subclavian artery...
  58. ncbi Endovascular treatment of thoracic disease: patient selection and a proposal of a risk score
    Claudia Maria Rodrigues Alves
    Federal University of Sao Paulo, Paulista School of Medicine, Sao Paulo, Brazil
    Ann Thorac Surg 73:1143-8. 2002
    ..Although selection criteria and subgroup analysis are still in the early developmental stages, endovascular treatment of aortic disease has become an alternative to surgery for many patients...
  59. ncbi Endovascular repair of abdominal and thoracic aortic aneurysms
    Barry T Katzen
    Baptist Cardiac and Vascular Institute, Miami, FL, USA
    Circulation 112:1663-75. 2005
  60. ncbi Quick, simple clamping technique in descending thoracic aortic aneurysm repair
    P Biglioli
    Department of Cardiovascular Surgery, University of Milan and Centro Cardiologico I Monzino Foundation IRCCS, Italy
    Ann Thorac Surg 67:1038-43; discussion 1043-4. 1999
    ..05). CONCLUSION: In descending thoracic aortic aneurysm repair, spinal cord perfusion can be maintained adequately without reimplantation of segmental vessels or ..
  61. ncbi Elective endovascular treatment of descending thoracic aortic aneurysms and chronic dissections with stent-grafts
    J Y Won
    Department of Diagnostic Radiology, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea
    J Vasc Interv Radiol 12:575-82. 2001
    ..CONCLUSIONS: For treatment of aortic dissection and saccular aneurysm of the descending thoracic aorta, endovascular stent-graft repair may be a technically feasible and effective treatment modality...
  62. ncbi Meta-analysis of open versus endovascular repair for ruptured descending thoracic aortic aneurysm
    Frederik H W Jonker
    Department of Surgery and Radiology, Sections of Vascular Surgery and Interventional Radiology, Yale University School of Medicine, New Haven, Conn 06510, USA
    J Vasc Surg 51:1026-32, 1032.e1-1032.e2. 2010
    Ruptured descending thoracic aortic aneurysm (rDTAA) is associated with high mortality rates. Data supporting endovascular thoracic aortic aneurysm repair (TEVAR) to reduce mortality compared with open repair are limited to small series...
  63. ncbi Endovascular repair of a thoracic aorta mycotic pseudoaneurysm in a patient with history of bacteroides fragilis sepsis and leprosy
    Michael D Beland
    J Vasc Interv Radiol 16:298-300. 2005
  64. ncbi Kommerell's diverticulum and right-sided aortic arch: a cohort study and review of the literature
    C S Cinà
    Division of Vascular Surgery, McMaster University, Victoria Medical Center, 304 Victoria Avenue North, Suite 305, Hamilton, Ontario L8L 5G4, Canada
    J Vasc Surg 39:131-9. 2004
    ..We feel that a left subclavian-to-carotid transposition completed before the thoracic approach revascularizes the subclavian distribution without increasing the complexity of the intrathoracic procedure...
  65. ncbi Etiology, pathogenesis and management of thoracic aortic aneurysm
    Huseyin Ince
    Division of Cardiology, University Hospital Rostock, Rostock School of Medicine, Rostock, Germany
    Nat Clin Pract Cardiovasc Med 4:418-27. 2007
    ..Although degenerative changes in the aortic wall are common to thoracic aortic aneurysm (TAA) and to various types of dissection in general, TAA can result from specific heritable disorders of ..
  66. pmc Distal aortic perfusion and cerebrospinal fluid drainage for thoracoabdominal and descending thoracic aortic repair: ten years of organ protection
    Hazim J Safi
    Department of Cardiothoracic and Vascular Surgery, The University of Texas Health Science Center at Houston Medical School, 6410 Fannin Street, Suite 450, Houston, TX 77030, USA
    Ann Surg 238:372-80; discussion 380-1. 2003
    ..To report the long-term results of our experience using cerebrospinal fluid drainage and distal aortic perfusion in descending thoracic and thoracoabdominal aortic repair...
  67. ncbi Challenges of endovascular tube graft repair of thoracic aortic aneurysm: midterm follow-up and lessons learned
    Sharif H Ellozy
    Division of Vascular Surgery, Mount Sinai School of Medicine, 5 East 98th Street, New York, NY 10029, USA
    J Vasc Surg 38:676-83. 2003
    ..This study analyzed a single center's experience with first-generation commercially produced thoracic stent grafts used to treat descending thoracic aortic aneurysms...
  68. ncbi Aortoesophageal fistula secondary to mycotic thoracic aortic aneurysm: endovascular repair and transhiatal esophagectomy
    Ruth C Van Doorn
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Endovasc Ther 9:212-7. 2002
    To report a case of aortoesophageal fistula secondary to a mycotic thoracic aortic aneurysm (TAA) successfully repaired by stent-grafting of the descending thoracic aorta.
  69. ncbi Expert consensus document on the treatment of descending thoracic aortic disease using endovascular stent-grafts
    Lars G Svensson
    Center for Aortic Surgery and Marfan Syndrome Clinic, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 85:S1-41. 2008
    ....
  70. ncbi Mid-term results for second-generation thoracic stent grafts
    R E Bell
    Department of General and Vascular Surgery, Guy s and St Thomas Hospital, London, UK
    Br J Surg 90:811-7. 2003
    ..Thoracic stent grafts offer an alternative to open surgery for thoracic aortic disease, but their long-term durability is unknown. This report includes mid-term follow-up for commercially available thoracic devices...
  71. ncbi Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome
    Ada W Y Chung
    Child and Family Research Institute, Department of Pediatrics, British Columbia Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Circ Res 101:512-22. 2007
    b>Thoracic aortic aneurysm (TAA) is the life-threatening complication of Marfan syndrome (MFS), a connective tissue disorder caused by mutations in the fibrillin-1 gene...
  72. ncbi Left heart bypass during descending thoracic aortic aneurysm repair does not reduce the incidence of paraplegia
    Joseph S Coselli
    The Michael E DeBakey Department of Surgery, Division of Cardiothoracic Surgery, Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Texas, USA
    Ann Thorac Surg 77:1298-303; discussion 1303. 2004
    ..The purpose of this retrospective analysis was to determine if the use of left heart bypass (LHB) reduced the incidence of paraplegia in patients who underwent DTAA repair...
  73. ncbi Serious complications following endovascular thoracic aortic stent-graft repair for type B dissection
    Beate Neuhauser
    Department of Vascular Surgery, University Hospital Innsbruck, Austria
    Eur J Cardiothorac Surg 33:58-63. 2008
    ..To describe our experience with endovascular stent-graft repairs in type B aortic dissection focusing on serious secondary complications resulting in immediate or late conversion to open repair...
  74. ncbi Descending thoracic aortic aneurysm repair: 12-year experience using distal aortic perfusion and cerebrospinal fluid drainage
    Anthony L Estrera
    Department of Cardiothoracic and Vascular Surgery, The University of Texas Houston Medical School, Memorial Hermann Hospital, Houston, Texas, USA
    Ann Thorac Surg 80:1290-6; discussion 1296. 2005
    ..The purpose of this report is to analyze our experience with regard to neurologic deficit (paraplegia and paraparesis) and mortality using the adjuncts of distal aortic perfusion and cerebrospinal fluid drainage...
  75. ncbi Mapping a locus for familial thoracic aortic aneurysms and dissections (TAAD2) to 3p24-25
    Sumera N Hasham
    Department of Internal Medicine, University of Texas Medical School at Houston, USA
    Circulation 107:3184-90. 2003
    ..2-q24 (FAA1). Further genetic heterogeneity for the condition was evident by the presence of TAAD in some families not linked to these known loci...
  76. ncbi Ascending thoracic aneurysms are associated with decreased systemic atherosclerosis
    Hardean Achneck
    Section of Cardiothoracic Surgery, Yale University School of Medicine, 333 Cedar St, 121 FMB, New Haven, CT 06520, USA
    Chest 128:1580-6. 2005
    ..It is our objective to determine whether there is a negative association between ascending thoracic aneurysms and systemic atherosclerosis...
  77. ncbi Familial thoracic aortic aneurysm/dissection with patent ductus arteriosus: genetic arguments for a particular pathophysiological entity
    Philippe Khau Van Kien
    INSERM U36, College de France, and Département de Génétique, Hopital Europeen Georges Pompidou, Paris, France
    Eur J Hum Genet 12:173-80. 2004
    b>Thoracic aortic aneurysm and aortic dissection (TAA and AD) are an important cause of sudden death. Familial cases could account for 20% of all cases...
  78. ncbi Aortic aneurysms secrete interleukin-6 into the circulation
    Joe Dawson
    St George s Vascular Institute, St George s Hospital, London, United Kingdom
    J Vasc Surg 45:350-6. 2007
    ..The aim of this study was to directly measure in vivo aortic IL-6 concentrations, testing the hypothesis that aneurysms secrete IL-6 into the circulation...
  79. ncbi Complex thoracoabdominal aortic aneurysms: endovascular exclusion with visceral revascularization
    Stephen Alan Black
    Regional Vascular Unit, St Mary s Hospital, Praed Street, London, United Kingdom
    J Vasc Surg 43:1081-9; discussion 1089. 2006
    ..We review our ongoing experience with a transabdominal stent repair of complex thoracoabdominal aneurysms (Crawford type I, II, and III) with surgical revascularization of visceral and renal arteries...
  80. ncbi Familial thoracic aortic aneurysms and dissections: three families with early-onset ascending and descending aortic dissections in women
    Van Tran-Fadulu
    Department of Internal Medicine, Division of Medical Genetics, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Am J Med Genet A 140:1196-202. 2006
    ..Thus, a novel unidentified loci may be responsible for the phenotype in these three families...
  81. ncbi A prospective study of medically treated acute type B aortic dissection
    A Winnerkvist
    Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden
    Eur J Vasc Endovasc Surg 32:349-55. 2006
    ..To study prospectively aneurysm formation, need of surgery, incidence of rupture and mortality in patients with conservatively treated acute type B aortic dissection...
  82. ncbi Endovascular repair of the thoracic aorta: lessons learned
    Frank J Criado
    Center for Vascular Intervention, Division of Vascular Surgery, Union Memorial Hospital, MedStar Health, Baltimore, Maryland, USA
    Ann Thorac Surg 80:857-63; discussion 863. 2005
    ..We sought to gain a better understanding of these issues through a retrospective review of our 8-year clinical experience in the treatment of thoracic aortic aneurysms and dissections...
  83. ncbi Thoracic aortic stent-graft devices: problems, failure modes, and applicability
    Christoph A Nienaber
    Division of Cardiology, University Hospital Rostock, Rostock School of Medicine, Rostock, Germany
    Semin Vasc Surg 20:81-9. 2007
    ..The aim of this work is to give an overview on thoracic aortic stent-graft devices with focus on problems, failure modes and potential improvements...
  84. ncbi Endograft exclusion of acute and chronic descending thoracic aortic dissections
    Tae K Song
    Division of Vascular, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Vasc Surg 43:247-58. 2006
    ....
  85. ncbi Ortner's syndrome and endoluminal treatment of a thoracic aortic aneurysm: a case report
    José F Guijarro Escribano
    Department of Vascular Surgery, Hospital Central de la Defensa Gomez Ulla, Madrid, Spain
    Vasc Endovascular Surg 40:75-8. 2006
    ..laryngeal nerve paralysis, confirmed by laryngoscopy, in a patient who was diagnosed with a saccular thoracic aortic aneurysm and treated with endovascular prostheses...
  86. pmc Gene expression signature in peripheral blood detects thoracic aortic aneurysm
    Yulei Wang
    Applied Biosystems, Foster City, California, United States of America
    PLoS ONE 2:e1050. 2007
    b>Thoracic aortic aneurysm (TAA) is usually asymptomatic and associated with high mortality. Adverse clinical outcome of TAA is preventable by elective surgical repair; however, identifying at-risk individuals is difficult...
  87. ncbi Long-term results from a 12-year experience with endovascular therapy for thoracic aortic disease
    Himanshu J Patel
    Department of Surgery, University of Michigan Hospitals, Ann Arbor, Michigan 48109 0348, USA
    Ann Thorac Surg 82:2147-53. 2006
    ..Endovascular approaches promise to revolutionize therapy for thoracic aortic disease. This study describes a long-term analysis of endovascular thoracic aortic repair...
  88. ncbi Endovascular treatment of complicated aortic aneurysms in patients with underlying arteriopathies
    Donald T Baril
    Division of Vascular Surgery, Department of Surgery, Mount Sinai School of Medicine, New York, NY, USA
    Ann Vasc Surg 20:464-71. 2006
    ..EVSG repair of aortic aneurysms is feasible and can be safely performed in patients with arteriopathies. Long-term durability in this younger group of patients who carry an ongoing risk of arterial degeneration remains to be determined...
  89. ncbi Results of endovascular repair of the thoracic aorta with the Talent Thoracic stent graft: the Talent Thoracic Retrospective Registry
    Rossella Fattori
    Cardiovascular Radiology, University Hospital S Orsola, Bologna, Italy
    J Thorac Cardiovasc Surg 132:332-9. 2006
    ..The Talent Thoracic Retrospective Registry was designed to evaluate the impact of this therapy on patients treated in 7 major European referral centers over an 8-year period...
  90. ncbi Outcomes of medical management of acute type B aortic dissection
    Anthony L Estrera
    Department of Cardiothoracic and Vascular Surgery, The University of Texas Houston Medical School, Memorial Hermann Heart and Vascular Institute, 6410 Fannin St, Suite 450, Houston, Texas 77030, USA
    Circulation 114:I384-9. 2006
    ..Currently, the optimal treatment of acute type B aortic dissection remains controversial. The purpose of this study was to report early clinical outcomes of medical management for acute type B aortic dissection...
  91. ncbi Hybrid approaches to thoracic aortic aneurysms: the role of endovascular elephant trunk completion
    Roy K Greenberg
    The Center for Aortic Surgery, Department of Vascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 112:2619-26. 2005
    b>Thoracic aortic aneurysm affecting the arch and proximal descending thoracic aorta requires 2-stage repairs that include proximal elephant trunk graft placement and completion of thoracic or thoracoabdominal repair...
  92. ncbi Single-stage repair of extensive thoracic aortic aneurysms: experience with the arch-first technique and bilateral anterior thoracotomy
    Nicholas T Kouchoukos
    Division of Cardiovascular and Thoracic Surgery, Missouti Baptist Medical Center, 3009 N Ballas Road, St Louis, MO, USA
    J Thorac Cardiovasc Surg 128:669-76. 2004
    ..We have used a single-stage technique for operative repair of most or all of the thoracic aorta...
  93. ncbi Thoracic aortic aneurysm patients with Chlamydophila pneumoniae infection showed a shift in trace element levels in serum and diseased aortic tissue
    Christina Nyström-Rosander
    Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
    J Trace Elem Med Biol 23:100-6. 2009
    ..pneumoniae-positive compared with C. pneumoniae-negative patients. The results are compatible with active infection and/or inflammation, possibly initiated by C. pneumoniae...
  94. ncbi In situ stent-graft fenestration to preserve the left subclavian artery
    Richard G McWilliams
    Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    J Endovasc Ther 11:170-4. 2004
    ..To report our first clinical application of a new technique for in situ fenestration of a thoracic stent-graft...
  95. ncbi Does profound hypothermic circulatory arrest improve survival in patients with acute type a aortic dissection?
    David T Lai
    Department of Cardiovascular and Thoracic Surgery, Stanford University School of Medicine, Stanford, Calif 94305 5247, USA
    Circulation 106:I218-28. 2002
    ..No evidence exists that profound hypothermic circulatory arrest (PHCA) improves survival or reduces the likelihood of distal aortic reoperation in patients with acute type A aortic dissection...
  96. ncbi Type A aortic dissection developing during endovascular repair of an acute type B dissection
    Fabrizio Fanelli
    Department of Radiological Sciences, University of Rome La Sapienza, Rome, Italy
    J Endovasc Ther 10:254-9. 2003
    ..To describe an extension of type B dissection into type A during endoluminal treatment of acute type B dissection...
  97. ncbi Thoracic endovascular aneurysm repair in Japan: Experience with fenestrated stent grafts in the treatment of distal arch aneurysms
    Satoshi Kawaguchi
    Department of Vascular Surgery, Center for Minimally Invasive Treatment of Cardiovascular Diseases, Tokyo Medical University, Tokyo, Japan
    J Vasc Surg 48:24S-29S; discussion 29S. 2008
    ..We have participated in joint design and assessment efforts with a stent graft manufacturer, focusing primarily on fenestrated stent grafts used in repairs at the distal arch, a site especially prone to aneurysm...
  98. ncbi Stent-graft placement in atherosclerotic descending thoracic aortic aneurysms: midterm results
    Martin Czerny
    Department of Cardiothoracic Surgery, University of Vienna Medical School, Vienna, Austria
    J Endovasc Ther 11:26-32. 2004
    ..To determine midterm durability and need for reinterventions after stent-graft placement in atherosclerotic descending thoracic aortic aneurysms...
  99. ncbi Endovascular repair of a right-sided descending thoracic aortic aneurysm associated with a right aortic arch and a left subclavian artery arising from a Kommerell's diverticulum
    Chris Klonaris
    First Department of Surgery, Vascular Division, Laikon Hospital, Athens University Medical School, 11 Zalokosta St, Psihico, Athens, 15452, Greece
    Cardiovasc Intervent Radiol 32:758-61. 2009
    This case report describes the endovascular repair of a right-sided descending thoracic aortic aneurysm associated with a right aortic arch and an aberrant left subclavian artery...
  100. ncbi Chlamydia pneumoniae in patients undergoing surgery for thoracic aortic disease
    Christina Nyström-Rosander
    Section of Infectious Diseases, Uppsala University Hospital, SE 75185 Uppsala, Sweden
    Scand Cardiovasc J 36:329-35. 2002
    ..To investigate if Chlamydia pneumoniae is present in the wall of the thoracic aorta in patients operated on for aneurysm or aortic dissection...
  101. ncbi Operative delay for peripheral malperfusion syndrome in acute type A aortic dissection: a long-term analysis
    Himanshu J Patel
    Department of Surgery, University of Michigan Hospitals, Ann Arbor, Mich, USA
    J Thorac Cardiovasc Surg 135:1288-95; discussion 1295-6. 2008
    ..This study evaluates the late outcomes with this approach...

Research Grants24

  1. Transforming Growth Factor-beta Signaling Pathways in Thoracic Aortic Aneurysms
    Jeffrey A Jones; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Thoracic aortic aneurysm (TAA) disease is a potentially devastating disease process which often causes death by rupture in the absence of symptoms...
  2. Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
    Scott A LeMaire; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Although thoracic aortic aneurysm and dissection (TAAD) are not as common as some forms of vascular diseases, e.g. coronary artery disease, it is a clinically insidious disease with high fatality...
  3. Age-Dependent Mechanisms in Thoracic Aortic Aneurysms
    John S Ikonomidis; Fiscal Year: 2013
    ..Because thoracic aortic aneurysm (TAAs) occur most frequently in persons 60-70 years of age, it follows that over the next two decades the ..
  4. Development Underpinnings of Acquired Aortic Aneurysm in Marfan Syndrome
    Mark E Lindsay; Fiscal Year: 2013
    ..factor beta (TGF-2) axis in human vascular disease has revolutionized the pathogenetic understanding of thoracic aortic aneurysm (TAA)...
  5. Genetic Etiology of Bicuspid Aortic Valve Disease
    Simon C Body; Fiscal Year: 2013
    ..biology and modifiers of disease progression for BAV to aortic valve stenosis and incompetence, and thoracic aortic aneurysm/dissection...
  6. AUTOIMMUNE AORTIC ANTIGENS IN ABDOMINAL AORTIC ANEURYSMS
    MARTIN TILSON; Fiscal Year: 2002
    ..mutations and polymorphisms that predispose individuals affected by Marfan syndrome to abdominal vs thoracic aortic aneurysm formation. Finally, in Project 3, Dr...
  7. Intracellular Signaling in Thoracic Aortic Aneurysms
    John Ikonomidis; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE Thoracic aortic aneurysm disease is a devastating disease process which often results in death because of a lack of aneurysm ..
  8. Matrix Metalloproteinases in Thoracic Aortic Dissection
    SCOTT LEMAIRE; Fiscal Year: 2009
    ..with aortic dissection;and 3) to investigate our hypothesis that MMP-9 overexpression is a key step in thoracic aortic aneurysm formation and rupture in a mouse model of aortic dissection...
  9. Extracellular Mechanisms For Thoracic Aortic Aneurysms
    John Ikonomidis; Fiscal Year: 2008
    Aneurysmal disease of the aorta is a common cause of death in the United States. Thoracic aortic aneurysm (TAA) patients are particularly challenging because of the complexity of surgical repair and high incidence of postoperative ..
  10. Homocysteine/Hypertension & Vascular Lesion Formation
    Peter Lin; Fiscal Year: 2008
    ..abstract_text> ..
  11. VOLUMETRIC ANALYSIS OF THE AORTA AND ITS BRANCHES
    Geoffrey Rubin; Fiscal Year: 2002
    ....
  12. Improving Radiologist Detection of Lung Nodules with CAD
    Geoffrey Rubin; Fiscal Year: 2008
    ..abstract_text> ..
  13. MECHANISMS OF ENDOTHELIAL DYSFUNCTION IN DIABETICS
    Joshua Beckman; Fiscal Year: 2003
    ..abstract_text> ..
  14. VEIN GRAFT PRESERVATION: THROMBOSIS & NEOINTIMAL DISEASE
    Yoshifumi Naka; Fiscal Year: 2004
    ..The current proposal is driven by the applicant?s desire to use a model of vein graft disease as a tool to learn how to undertake basic studies to elucidate mechanisms of early and late vein graft failure...
  15. Retrograde In Situ Isolated Cardiac Gene Delivery
    Charles Bridges; Fiscal Year: 2004
    ..Further development of this approach may ultimately lead to the development of clinically relevant techniques of therapeutic cardiac gene delivery for the treatment of heart failure of diverse etiologies. ..
  16. Osteoprotegerin and osteopontin in aortic aneurysm
    Jonathan Golledge; Fiscal Year: 2009
    ..Understanding the role of these calcium-controlling proteins in artery weakness and how drug therapy can interfere in these effects is an important step in the development of new treatment for aortic aneurysm. ..
  17. MMP-9-Dependent Vessel Wall Remodeling is NO-Dependent
    Gilbert Upchurch; Fiscal Year: 2005
    ....
  18. Myocardial regeneration in ischemic cardiomyopathy
    Marc Penn; Fiscal Year: 2009
    ....
  19. Vein wall remodeling after DVT is matrix metalloproteinase dependent
    Peter Henke; Fiscal Year: 2009
    ..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
  20. Genetic Basis of Aortic Aneurysms/Dissections
    Dianna Milewicz; Fiscal Year: 2009
    ..Therefore, identification of the genes that predispose individuals to TAAD is critical in preventing premature deaths due to dissections. ..
  21. Thrombus resolution is CXC chemokine dependent
    Peter Henke; Fiscal Year: 2006
    ..abstract_text> ..
  22. Non-viral controllable gene delivery for neuroprotection
    JAMES HECKER; Fiscal Year: 2007
    ..Neuroprotection strategies designed for pre-operative use will also have significant application for attenuation of secondary injury following stroke, brain or spinal cord trauma, or neurodegenerative diseases. ..
  23. CHARACTERIZING MICROFIBRIL ABNORMALITIES IN SCLERODERMA
    Dianna Milewicz; Fiscal Year: 2003
    ..The research proposed in this grant will determine the contribution of abnormalities in fibrillin-1-containing microfibrils to the activation of fibroblasts, which leads to the fibrosis that characterizes SSc. ..
  24. New ECG Criteria for Posterior Myocardial Infarction
    Shu Fen Wung; Fiscal Year: 2004
    ..This study will aid in the detection and follow-up of patients with posterior myocardial infarction. ..